<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV89</accession>
    <name>A0A1E7MV89_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480863.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6939"/>
    <dbReference type="EnsemblBacteria" id="OEV32350">
        <property type="protein sequence ID" value="OEV32350"/>
        <property type="gene ID" value="HS99_0016755"/>
    </dbReference>
    <dbReference type="OMA" id="PGEPWYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9528" checksum="F45FD0C51D56417C" modified="2017-01-18" version="1">MTAIVVLFELEQDEALGPDGVEPVVCAVHAAGGDPDVPEDPLPRTLCGLDTDPMEHSHYRPARPGEPWYPPALADRRCLACEAALRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE9</accession>
    <name>A0A1E7MVE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7008"/>
    <dbReference type="EnsemblBacteria" id="OEV32409">
        <property type="protein sequence ID" value="OEV32409"/>
        <property type="gene ID" value="HS99_0017095"/>
    </dbReference>
    <dbReference type="OMA" id="LVWAYTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198462" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23970" checksum="EAF64919CCC3E0F3" modified="2017-01-18" version="1">MTRVRLVLALALLAATAATGLAVAVSTGWGGGGGGPARPWTDGSVHGPWRSVFDGHGENTGLDDGLSLSPMPSRTASETHAGLIVSTRQYRDMDLKARMRTVAQLRTPTPNPWEVPWLVWAYSDPEHFYYLILKPNGWELGKRDPVYPGGQRFLATGPDQFPVGPWSGVTVAQRGAHLEVSVDGRALVSYQDDERPYPAGSVGAYTEDARVEFTDIAVEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVQ4</accession>
    <name>A0A1E7MVQ4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553808.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6931"/>
    <dbReference type="EnsemblBacteria" id="OEV32343">
        <property type="protein sequence ID" value="OEV32343"/>
        <property type="gene ID" value="HS99_0016715"/>
    </dbReference>
    <dbReference type="OMA" id="FPSELCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21045" checksum="D97F5577A91E681C" modified="2017-01-18" version="1">MKAAEGFPSGLCAQHRAIEALLRQLDGVRTRGGTSDEEDLRLLAALRRLLLPHLAAEEEHLYPLARRYLPVGRALADAAGCTHASIRRLLDRADDCRLSVTGRRRATAVLLLVLRTHLRGEEEQLFPALRARARPDELRRCERRLREPRAGPPGATGPAGPAGPAVRGLPPGAGAITALRDRLTGHDNSGQHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV5</accession>
    <name>A0A1E7MVV5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">radA</name>
        <name evidence="3" type="ORF">HS99_0040090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284400.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8131"/>
    <dbReference type="EnsemblBacteria" id="ARF79766">
        <property type="protein sequence ID" value="ARF79766"/>
        <property type="gene ID" value="B6264_13395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32567">
        <property type="protein sequence ID" value="OEV32567"/>
        <property type="gene ID" value="HS99_0040090"/>
    </dbReference>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1 2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Lon-protease-like" evidence="1">
        <location>
            <begin position="355"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="1">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="503" mass="52735" checksum="93921F5527212A63" modified="2017-01-18" version="1">MPPRSKTTAKPRPAYRCTECGNQLPKWVGRCPECNAWGTVEEYGAVPIRTTAAGPVSAPARPIAQVDGQVATARSTGVPELDRVLGGGLVPGAVVLLAGEPGVGKSTLLLDVAAKAATGQHRTLYVTGEESAGQVRLRADRINALSEHLYLAAEQDLGAVLGHIEAVNPGLLILDSVQTIASAELDGAPGGPAQVREVAGALIRASKERGMATLLVGHVTKDGQIAGPRLLEHLVDVVLSFEGDRHARLRLIRGVKNRYGATDEVGCFELHDEGIVGLADPSGLFLTRRDKPVPGTCLTVTLEGKRPLVAEVQALMVDSQIPSPRRTTSGLESPRIAMILAVVERHGGVKLGKQDIYTATVGGVKLTEPSADLAVALAVASSSTDTPLPSNLVAIGEVGLAGEVRRVTGVQRRLAEAHRLGFTHALVPPDPGKVPPGMKVVEVADIGEALRAIPGRRRAAAKPRVEGRGEAPSTPPAPRAAKVPAYPEELMDGWEPLDSDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW06</accession>
    <name>A0A1E7MW06_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole acetimide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3834"/>
    <dbReference type="EnsemblBacteria" id="ARF78345">
        <property type="protein sequence ID" value="ARF78345"/>
        <property type="gene ID" value="B6264_04910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32615">
        <property type="protein sequence ID" value="OEV32615"/>
        <property type="gene ID" value="HS99_0015170"/>
    </dbReference>
    <dbReference type="OMA" id="YRWFTSN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="49662" checksum="1E81D2B23B75BCCA" modified="2017-01-18" version="1">MWKLSATAIAAAVRGGEVSAREVVDAHLARIAEVNPRVNAVTQLLADRARAAARETDRARAAGEPLGPLAGVPFTVKECTRIEGVPTTFGTPRFRELVAPADAVPVARLRAAGAIPIGHSNMPTLILAGMHTRSELYGDTRNPWDAARTPGGTSGGDGVAVATGMAALGLGNDSGGSVRIPATFCGVAALKPTTGRFAADQRMLGPTDPGPASQLLVTDGPLARTVADLRLAYETLAGPDPRDPRAVPAPLYGEPPHGGPLDGRPRVAVVADPGGHGVHPSVRRAVEGAAEALRDAGYQVDEVPDVPRLDEALKAYHQLTSTEFAPSWPAVRQLLGEGGDRFIELTMRHNPPVDAAGLIRLMGTWMNIRRSWTEFLDAYPLLLGPVFTEPPVEPGLESRDQAGRDRVASAMRLCSVTSFVGVPAVAVPTGLDAEGLPTGVQLIGRPFREDLCLAAAQHVEDRLGTLTPIDPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW26</accession>
    <name>A0A1E7MW26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287862.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000296.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78328">
        <property type="protein sequence ID" value="ARF78328"/>
        <property type="gene ID" value="B6264_04815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32631">
        <property type="protein sequence ID" value="OEV32631"/>
        <property type="gene ID" value="HS99_0015265"/>
    </dbReference>
    <dbReference type="OMA" id="PVHYGFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="202" mass="20434" checksum="E7C571A2CF667E89" modified="2017-01-18" version="1">MAVPRILLAAAALTATALAGLTGCTPADTRPTVTAASSAAALADDGTDDLLDEDGFGDDLADDGDYAAGPVAVPAAPAAPAPECTAPEVDPGHQVVVVVAAGPAELTAQPARFTCTPSRYEATGTPVHYGFAAAGVTATLVDRPHEEAAEPVQLDELVTHLNDCLAERDPADPYGCSGNAYDVVLDPHGRITRIAEVEVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW94</accession>
    <name>A0A1E7MW94_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387349.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000836.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78252">
        <property type="protein sequence ID" value="ARF78252"/>
        <property type="gene ID" value="B6264_04365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32708">
        <property type="protein sequence ID" value="OEV32708"/>
        <property type="gene ID" value="HS99_0015720"/>
    </dbReference>
    <dbReference type="OMA" id="SAERACW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16226" checksum="F17892B2E6A06092" modified="2017-01-18" version="1">MTAQNSAARAAFPARISIVTLGVSDLDRSARFYEDLGWKRSSASSPEIVWFRTADSVLGLFPSEELAADAGVPATGEPSFRGVTLAVNLESPELVDAALRTAVEAGAVVVKPPVPTSWGGYSGYFEDPDGHLWELAHNPFFPFTEDGSLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM1</accession>
    <name>A0A1E7MWM1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6107"/>
    <dbReference type="EnsemblBacteria" id="OEV32814">
        <property type="protein sequence ID" value="OEV32814"/>
        <property type="gene ID" value="HS99_0016060"/>
    </dbReference>
    <dbReference type="OMA" id="ESGMARH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29184" checksum="D371975F06BA99B7" modified="2017-01-18" version="1">MRRRRWARDRELRAPRSPQHLSTADFLTLGNAVCGFLAIYSITTGVLIPHITNPDAAPDRHSAATAVTLLLIGSMCDLFDGLVARKLRSSALGAELDNLADLISFGIAPAYFVAVWGMVSQGSNRTLSALIALTVLLAVVLRLARFSAVKMRPGVFQGMPCPMGAMTVIAIVLLDPPFLPGLLAIFGAAYLMVSRIEYPKPQGLLATATLCWVVVAIGCLAAWATGLPGGDTLMHVGAFAQITLAAMAPLLVIRRKVGQKVGDVRARRAESRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS7</accession>
    <name>A0A1E7MWS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289958.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000586.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene72"/>
    <dbReference type="EnsemblBacteria" id="ARF80132">
        <property type="protein sequence ID" value="ARF80132"/>
        <property type="gene ID" value="B6264_15465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32869">
        <property type="protein sequence ID" value="OEV32869"/>
        <property type="gene ID" value="HS99_0039780"/>
    </dbReference>
    <dbReference type="OMA" id="QVWTNNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="35663" checksum="E329037D4305E3B0" modified="2017-01-18" version="1">MDLDVFVATHQGEWARLDALARRPRLSGEEADELVTLYQRATGHLAKVQAAAPDPALIGRLTGLVSRARSAVTGARTNGWQDVARYYTVSFPAALYRARRWWVPVAAVSMAATVLLAWWMATHPEVRNSLVTPDDLREMTRPGGQYEAYYSDRPASSFAAQVWTNNAWIAVQCLLYGIALGIPVLLVMWTNVVNLGVGIGLMASAGRLDVFLGLLIPHGLLELTAVFVAGGLGLRLGWTVIDPGPRTRTVALAEQGRSIIGMSIGLATVLAVSGVLEAFVTPSGLPTWARISIGVLAEVAFLLYALVLGRKAAQGGEVGDVDAADRADLQPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX22</accession>
    <name>A0A1E7MX22_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552515.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5746"/>
    <dbReference type="EnsemblBacteria" id="ARF81377">
        <property type="protein sequence ID" value="ARF81377"/>
        <property type="gene ID" value="B6264_22900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32964">
        <property type="protein sequence ID" value="OEV32964"/>
        <property type="gene ID" value="HS99_0013870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9507" checksum="0BE330A8C7757864" modified="2017-01-18" version="1">MPPSDPRSACSPSAPTSRCPPTSPASPTFHAAVPDPADHEPIRAQVPLGRLGRAEDVAETVAFLLSERSSYITGQDLVIDGGLVPAFPSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX60</accession>
    <name>A0A1E7MX60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278459.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000499.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1986"/>
    <dbReference type="EnsemblBacteria" id="ARF79568">
        <property type="protein sequence ID" value="ARF79568"/>
        <property type="gene ID" value="B6264_12160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32823">
        <property type="protein sequence ID" value="OEV32823"/>
        <property type="gene ID" value="HS99_0040000"/>
    </dbReference>
    <dbReference type="OMA" id="FAIPSMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="553" mass="59701" checksum="03A8A23BBF634FE6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ5</accession>
    <name>A0A1E7MXJ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5725"/>
    <dbReference type="EnsemblBacteria" id="OEV33149">
        <property type="protein sequence ID" value="OEV33149"/>
        <property type="gene ID" value="HS99_0013975"/>
    </dbReference>
    <dbReference type="OMA" id="AAYSPYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="208"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="44722" checksum="8C35A27E6ADF879D" modified="2017-01-18" version="1">MINHPTVQRLRTAATRLGSGPGAAPPPRTTRRGQAFDLALALFLSYTCGRYAIVAHRTHDAHGTTWNELLLLVPLVPLPLVLRRRHPLAALWTVLPAALLVRSQHPDIAFWEGVVVIVAAYSAAAYGRHPNALLLSLSAATGALAVLFDDALLPHFPNSVVALLVLVPVFAVAYELRMWRRRVEEGRERLSALERDRLAALQRAVEHERARIARELHDVVTHNVSMMTIQAGAARKILDTAPDRAREAMAAVESGGRAAMTELRHVMGLLTMDSDTGDDPAASADLSPQPGLGRLDALVDGVRRAGLPVELTVRGERRAVPPGVELAAYRVVQEALTNTVKHAGGADAEVTVDYAPDGLRVEVTDTGGRPTGAAATGNGRGLLGLRERLAVYGGTLHTGPRPRGGYRVTASIPLESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS3</accession>
    <name>A0A1E7MXS3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0039045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290996.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000141.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene533"/>
    <dbReference type="EnsemblBacteria" id="OEV33250">
        <property type="protein sequence ID" value="OEV33250"/>
        <property type="gene ID" value="HS99_0039045"/>
    </dbReference>
    <dbReference type="OMA" id="CGEFHPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="48789" checksum="C2880996B360B00B" modified="2017-01-18" version="1">MTTATAPKSRPASAGPRHRAAAHPPLALPPNAALGLIAAGALGVLGLWWVNTASVVGAAGWLTGAGRITGLLAGYAAPVLLLLMARLPPVERGVGADRLARWHAYGGRWLVALVSVHVLTVVWGYALTDGRGLVGEGVEIVFHYPEMVKASLGTLLMLGTGLVSARAARRRLSYETWYYLHLATYLAVALAFAHQLATGADLGGGPGQAGWYALYFGTAALLGWFRLLRPWLLDRRHGLRVAEVRPEGPGVVSLFLSGRRLEELRAEPGQFFRLQFQAPGLRWAANPYSLSAPPRPDFLRFTVKDLGGHSAAVAALRPGTRVRAEGPYGAFTGRQQRQHRVLLLGVGVGITPLRALFETLPGEVTLVQRARRAEDVLFRAELAEVARRRGAVVHELLGSREQVGDLGAALARLVPGLAEHDVYLCGPEAVAEEAVRALRAAGVRAGRIHRESFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU7</accession>
    <name>A0A1E7MXU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387581.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5627"/>
    <dbReference type="EnsemblBacteria" id="ARF81479">
        <property type="protein sequence ID" value="ARF81479"/>
        <property type="gene ID" value="B6264_23490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33063">
        <property type="protein sequence ID" value="OEV33063"/>
        <property type="gene ID" value="HS99_0014460"/>
    </dbReference>
    <dbReference type="OMA" id="CAAWSFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="23836" checksum="B8764E216D3077E8" modified="2017-01-18" version="1">MQLSHARRNSLITGVATIVVASAATAALAIPQTAHHAEAAAPVAAVSVDGKPVGDQGQADAAAAAEKAAQDAKAAQDAQAAQAAQEAQAKAQADAAAQAQAQADAKAQADAKAQADAKAQADAAASRSQQRQNLNSYSGTPQQIAAQIVPAGQLQCFSNIVFRESSWNPLAVNASSGAYGLVQALPGSKMASAGADWRTNPATQIKWGLDYMNSRYGSPCSAWSFWQAHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY13</accession>
    <name>A0A1E7MY13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283843.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7028"/>
    <dbReference type="EnsemblBacteria" id="ARF80423">
        <property type="protein sequence ID" value="ARF80423"/>
        <property type="gene ID" value="B6264_17255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33322">
        <property type="protein sequence ID" value="OEV33322"/>
        <property type="gene ID" value="HS99_0012025"/>
    </dbReference>
    <dbReference type="OMA" id="PNAMCIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="39077" checksum="E0E4C82D87B0CC0F" modified="2017-01-18" version="1">MTDTTAKAPSRRRQRFPEISTRAWEHPADRSALVALRKLSGFDDILKKLAGLVSERSIRLMFLATAVKTSERQFPELYDMVRDAAYVLDLDQVPDLYVTQDPAVNAFTIGIDTPIIVITSGLVELLDEEELRSVIGHEVGHAMSGHAVYRTMLMILTNIATRIAWVPLGNLAIMALVTALKEWFRKAELSSDRAGLLAGQDLQASMRALMKLAGGHNLAEMNVDAFLEQAEEYEKAGDLRDGVLKLLQLLPQTHPFAVVRVAQLKKWAESDEYRSITAGAYPRRSDDRDTSVGEQWKAAAEHYTTSVKESKDPLMGLLRDVAGGAATVGGKLRDTFTGGGRTGSPTDHGSAERTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY65</accession>
    <name>A0A1E7MY65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0012420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4003"/>
    <dbReference type="EnsemblBacteria" id="ARF80491">
        <property type="protein sequence ID" value="ARF80491"/>
        <property type="gene ID" value="B6264_17645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33388">
        <property type="protein sequence ID" value="OEV33388"/>
        <property type="gene ID" value="HS99_0012420"/>
    </dbReference>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="61"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="421"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="539"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="902" mass="98005" checksum="7B313F7E87053BCC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI9</accession>
    <name>A0A1E7MYI9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282362.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000252.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5174"/>
    <dbReference type="EnsemblBacteria" id="ARF80605">
        <property type="protein sequence ID" value="ARF80605"/>
        <property type="gene ID" value="B6264_18350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33502">
        <property type="protein sequence ID" value="OEV33502"/>
        <property type="gene ID" value="HS99_0013130"/>
    </dbReference>
    <dbReference type="OMA" id="SHFNKAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="27285" checksum="0DC628466FF1FBF0" modified="2017-01-18" version="1">MLVLLPPSEGKAASGDGEPVALDRLSLPGLTAARGAVLDALVGLCRGDEDTAAEVLGLTPGLRGEIAKNAGLPAAGARPAAEVYTGVLFDNLGLATLDAAAYDRAERSLLVFSGLWGAVRISDRIPSYRCSMGVKLPPLGALGAYWRSATATVLPEVADGLVLDLRSSAYAAAWKPAGEVASRTATVRVLQERDGKRTVVSHFNKATKGRIVRDLLVAGAEPKTPDELMDALLALGHHVELAAEGTARRPWQLDVVVTEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYN4</accession>
    <name>A0A1E7MYN4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549950.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7MYN4"/>
    <dbReference type="STRING" id="1894.JOER01000001_gene5214"/>
    <dbReference type="EnsemblBacteria" id="OEV33534">
        <property type="protein sequence ID" value="OEV33534"/>
        <property type="gene ID" value="HS99_0013330"/>
    </dbReference>
    <dbReference type="OMA" id="MMMTANG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="115"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="36871" checksum="53F4B465AAD67223" modified="2017-01-18" version="1">MTDNGEIIAQPVIQLRELGLAAAGAAAVRAAARLGLADALGDEPAGAAELARAVNADPDTLQRLLRALACYGVFAEQPDGRYVHTGASRLLREDTPRSLKDMVLWGTEPWTWELWGHLDEAVRTGKAVFPELHGMDFFDHLHAHSPESAAVFDRAMTQSSRLSALALADRLDLGGVGTVVDIAGGQGHVLATLLERNPGLRGTLLDLPEVVSGADARLRPGGALAGRATLLGGDCRREIPVQADVYLLKNILEWDDESTVLTLRNVVRAAAPGSRVIVVENLVDGSPELRFTTAMDLLLLLNVGGRKHTRAGLVSLIEEAGLTRAEVRPVNSYLHLVESVVPERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT3</accession>
    <name>A0A1E7MYT3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0012415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553457.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4004"/>
    <dbReference type="EnsemblBacteria" id="ARF82887">
        <property type="protein sequence ID" value="ARF82887"/>
        <property type="gene ID" value="B6264_17640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33584">
        <property type="protein sequence ID" value="OEV33584"/>
        <property type="gene ID" value="HS99_0012415"/>
    </dbReference>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="11">
        <location>
            <begin position="14"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="373" mass="40391" checksum="F62A71D9575B4DEA" modified="2017-01-18" version="1">MDIGPIKVWPPVVLAPMAGITNAPFRTLCREQSGGKGLYVSEMITTRALVERNAKTMQLIKFDPSEKPRSIQLYGVDPVTVGKAARMIADEGLADHIDLNFGCPVPKVTRKGGGSALPYKRNLLREILREAVANAGDLPVTMKMRKGIDDDHLTYLDAGRIGAEEGVAAIALHGRTAAQHYGGTADWSAIARLREAVPAHVPVLGNGDIWSADDALRMMRETGCDGVVVGRGCLGRPWLFRDLVSIFEGDVDYARPDFGYVARAMVRHAQLLGEWLGDEARGVIDFRKHVAWYTKGFSVGSELRVKLANSSSLTELAETLAQVEQTQTWPIGADGPRGRTSGNGRVVLPEGWLDDPYDCARPGEDAESDTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYY2</accession>
    <name>A0A1E7MYY2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="8" type="ORF">HS99_0038540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1098"/>
    <dbReference type="EnsemblBacteria" id="ARF78983">
        <property type="protein sequence ID" value="ARF78983"/>
        <property type="gene ID" value="B6264_08685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33637">
        <property type="protein sequence ID" value="OEV33637"/>
        <property type="gene ID" value="HS99_0038540"/>
    </dbReference>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="30141" checksum="776F5D588F5BA68B" modified="2017-01-18" version="1">MTGVLVLAGTPIGDVSDAPPRLLTELATADVIAAEDTRRLRRLTQALGVTPAGRVVSYFEGNEVGRTPELVEALLGGARVLLVTDAGMPSVSDPGYRLVAAAVEADVKVTAVPGPSAVLTALALSGLPVDRFTFEGFLPRKAGDRARQLASIAAEPRTMVFFEAPHRIAEALAAMAEAFGPERPAAVCRELTKTYEEVKRGPIGELAAWAAEGVKGEITVVVAGAPPAAPRELTPAELARLVAVREEAGERRKEAIAAVAVELSVPKREVFDAVVAAKKEASGEALKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ41</accession>
    <name>A0A1E7MZ41_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278530.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1946"/>
    <dbReference type="EnsemblBacteria" id="ARF79603">
        <property type="protein sequence ID" value="ARF79603"/>
        <property type="gene ID" value="B6264_12370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33702">
        <property type="protein sequence ID" value="OEV33702"/>
        <property type="gene ID" value="HS99_0038115"/>
    </dbReference>
    <dbReference type="OMA" id="WDAFWGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14447" checksum="C65504569764BE15" modified="2017-01-18" version="1">MDRTPAPQFAFVGLAVADMAASVAFYRRLGLVFPEGSEQEPHVETELPGGLLLVLDTEATIRSFHPDRQPPTGGARAALAFRCQSPAHVDAVYRELTDAGYHGELKPWDAFWGQRYASLLDPDGNGVDLLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ42</accession>
    <name>A0A1E7MZ42_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278538.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1940"/>
    <dbReference type="EnsemblBacteria" id="ARF82786">
        <property type="protein sequence ID" value="ARF82786"/>
        <property type="gene ID" value="B6264_12400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33720">
        <property type="protein sequence ID" value="OEV33720"/>
        <property type="gene ID" value="HS99_0038145"/>
    </dbReference>
    <dbReference type="OMA" id="WAMAMIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="39935" checksum="F8B2AD019783F61B" modified="2017-01-18" version="1">MGYRELLGRPGIRPWLLVTLAAKLPVAMAPLALVFLVRETSGGYTLGAVLGGAYVVGEVVGAPLLGARLHGARLRRELSLGLLGGAGAFAGLAFCHSAPPALAVVLAFLAGAAPSAHAGGLRALLVAAVPEHGVARALSVETTLSQAIWAVAPAAVAFLALGAAPGAPLGLAACCAALAAAGVRMLPAADTDGEQAGRGAAEPPSRGRALAAGWPVYLTSAAAMALLATAELVLPALLESRGLPVSWSGPLLTVFSVASVVGGLLYGARRWPGGPRAQSLVLLVAMAAFVALIAVLPGLVGIAVGLVLAGAFKSGVMVTRNLSLRERVPAGMLAAGYSLMYAVQGVGYSLTASLTAVILANAEPGTAVLCGAALTLLLTLVSASAEYRSHGAQLEAPTDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA5</accession>
    <name>A0A1E7MZA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289110.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3780"/>
    <dbReference type="EnsemblBacteria" id="ARF78394">
        <property type="protein sequence ID" value="ARF78394"/>
        <property type="gene ID" value="B6264_05195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33768">
        <property type="protein sequence ID" value="OEV33768"/>
        <property type="gene ID" value="HS99_0037800"/>
    </dbReference>
    <dbReference type="OMA" id="MWRVLST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="19610" checksum="9F195ABA39D65B98" modified="2017-01-18" version="1">MWRVLSTRGFEGLTLRAVAAELGASTGLLTHYFPNKRALLSHALEELDRRSAARPRRLAPVDGTPPPPVGLARLRAALLDVLPLDEATEAGNRIWVSSWDVALADPELAAAHAERYARSRVALTAHVADAQRLGELPADADPAGLAAGAQAFVLGLVVQSLFAPAEFPAERQIALLDAYLAGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD0</accession>
    <name>A0A1E7MZD0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0037890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289141.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3762"/>
    <dbReference type="EnsemblBacteria" id="ARF78412">
        <property type="protein sequence ID" value="ARF78412"/>
        <property type="gene ID" value="B6264_05285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33784">
        <property type="protein sequence ID" value="OEV33784"/>
        <property type="gene ID" value="HS99_0037890"/>
    </dbReference>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="47714" checksum="62AF4DEEC8D9A7C0" modified="2017-01-18" version="1">MSDNSVVLRYQDGEYEYPVVESTAGNSGFDISKLLPQTGLVTLDNGFGNTAAYKSAITFVDGDNGILRYRGYPIEQLAAQGGFIETAYLLINGELPNADQLAEFNREITQHTLLHEDVKRFFQGFPRDAHPMAMLSSVVGALSTFYPESHNPFDAAQRHLSTVRLLAKLPTIAAYAYKKAMGQPFVYPRNDLSYVENFLRMTFAVPAEDYELNPVVVNALDKLLILHADHEQNCSTSTVRLVGSSHANLFASISAGISALWGPLHGGANQAVLEMLESIQKDGGDVDAFITKVKNKEAGVKLMGFGHRVYKAFDPRAAQVKLLAHEVLGQLGKSDELLEIALKLEEHALKDDFFISRKLYPNVDFYTGLIYRAMGFPTSMFTVLFALGRLPGWIAHWHEMINDPTSRIGRPRQIYTGTAIRDYVELDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU9</accession>
    <name>A0A1E7MZU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551710.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2193"/>
    <dbReference type="EnsemblBacteria" id="ARF77824">
        <property type="protein sequence ID" value="ARF77824"/>
        <property type="gene ID" value="B6264_01785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33968">
        <property type="protein sequence ID" value="OEV33968"/>
        <property type="gene ID" value="HS99_0010940"/>
    </dbReference>
    <dbReference type="OMA" id="YRSAGWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="18900" checksum="D877264A0D0FE609" modified="2017-01-18" version="1">MSSTAYVVEELTAEELDGSVAEFAGLLADTVNCGASVGFLAPLEPEESSAWWRALVPELAAGRLLVWTARAADDGRLAGTVQLRPAATANGRHRGEVAKLMVHPADRGHQLAGRLLAALEERAAASGIRLLVLDTETGSPAERMYEAAGWSRVGTVPDYAADPMGTLRPTTIFFKSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV9</accession>
    <name>A0A1E7MZV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homogentisate 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0011005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2207"/>
    <dbReference type="EnsemblBacteria" id="ARF77836">
        <property type="protein sequence ID" value="ARF77836"/>
        <property type="gene ID" value="B6264_01850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33978">
        <property type="protein sequence ID" value="OEV33978"/>
        <property type="gene ID" value="HS99_0011005"/>
    </dbReference>
    <dbReference type="OMA" id="PYNHSNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="44062" checksum="AF69DB164429920D" modified="2017-01-18" version="1">MAYYRQLGSIPPKRHTQHRTPEGGLYYEELMGEEGFSSDSSLLYHRGIPSAVVNAAPWELPDQSTVPNHPLLPRHLKLHELFADQEWKSADVVGSRRLVLGNGDVRISYVAAGAPSELYRNGLGDECVYVESGSGTVETVFGSIEVGQGDYVIIPRATTHRWVPAGDEPLRAYCIEANSHITPVKRYLSKYGQLLEHAPYCERDLRGPVGPLVVDSPGDVDVLVKHRGPNGVSGTRYTVPHHPFDVVGWDGCLYPYAFNIRDFEPITGRIHQPPPAHQVFEGNGFVICNFVPRKVDYHPLSIPVPYYHANVDSDEVMFYCGGDYAARKGSGIGQGSISLHPGGHTHGPQPGAYERSIGVDFFDELAVMVDTFRPLELGEGGRASEDSNYAWTWAGRGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G2</accession>
    <name>A0A1E7N0G2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">HS99_0011265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2264"/>
    <dbReference type="EnsemblBacteria" id="ARF82568">
        <property type="protein sequence ID" value="ARF82568"/>
        <property type="gene ID" value="B6264_02115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34165">
        <property type="protein sequence ID" value="OEV34165"/>
        <property type="gene ID" value="HS99_0011265"/>
    </dbReference>
    <dbReference type="OMA" id="CQHIIVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33346" checksum="E247DE9B63D822AC" modified="2017-01-18" version="1">MPRLDPRHYEPARVPHQVRRYAGTPDTLAVGRPGKVGLLELAFERIGGRTELTGHYQKSPLQIMRPLYFDPARPDLAVTLLMSTGGGILQADRLRTDIRCGADTAVHLTTQAATKVYRMEHDYATQLVNLEAGPGAYVEYLPEPVIPFVDSRFYQRTVLTADAGATVLAGETVLAGRLARGERNAYRVFASDLEVRRPGGELVALDTVRLEPADGGVAGRAVLGGHDVMSSLYVLSPLAPAARIADVLHEALAERGLLYGVSVLPQDSGAWLRLLDSDTRACAAALRAAWEAVRRLLIGAPAPDLRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G3</accession>
    <name>A0A1E7N0G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551723.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2208"/>
    <dbReference type="EnsemblBacteria" id="ARF82559">
        <property type="protein sequence ID" value="ARF82559"/>
        <property type="gene ID" value="B6264_01855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34161">
        <property type="protein sequence ID" value="OEV34161"/>
        <property type="gene ID" value="HS99_0011010"/>
    </dbReference>
    <dbReference type="OMA" id="FEQHGFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="28654" checksum="4F89346D0533E1E5" modified="2017-01-18" version="1">MFRGLFDDAAVFPPGNLPVVEAVPAHRAHRTAWYADAVGPLLCGAGRLGELAAAVEGTGPLRVGLVLPGGSAELGPALTATAPFELAGVELATRDTAEAVAELDRLLPPDVPAAVELPRELLRGDGLDETLDVLVDSAYRAKFRTGGVVAEAFPDEDELAAFLTGCARRGLPYKCTAGLHNAARHTDPETGFEHHGFLNVLLAAQETDRAAAAEVLAERDGEVLAKAVRALSGHQVTVIRNSFTAFGTCSITEPLDDLAALGLLSPSPLVQEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H7</accession>
    <name>A0A1E7N0H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557290.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82578">
        <property type="protein sequence ID" value="ARF82578"/>
        <property type="gene ID" value="B6264_02775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34182">
        <property type="protein sequence ID" value="OEV34182"/>
        <property type="gene ID" value="HS99_0011920"/>
    </dbReference>
    <dbReference type="OMA" id="WGMSEAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34700" checksum="F0684F6440333D96" modified="2017-01-18" version="1">MQHVSLGALAVSRIGLGTMSMSDYYTGAGDDDAESVRTIRRALDLGVNFLDTAEIYGPFTNEELVGRAIAGRRDEVVLATKFGLVAHGGAGPNTLDSSPANVRAAVEGSLRRLGTDRIDLYYQHRVDPDIPIEETIGAVAELVREGKVRHIGLSEAGPETVRRAHAVHPVTAVQTEYSLWTRDPEAALLPLLRELGIGLVAYSPLGRGFLTGTIRSADQLDAHDFRLTTPRFSGENLDANLRIVDEVEQVAAEAGATAAQVALAWLLARGEDIAPIPGTRRSARVEENAAAAAVTLTPAQLGRLDTLRPAVGARYAEQDLARTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K1</accession>
    <name>A0A1E7N0K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554573.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6050"/>
    <dbReference type="EnsemblBacteria" id="ARF78143">
        <property type="protein sequence ID" value="ARF78143"/>
        <property type="gene ID" value="B6264_03740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34227">
        <property type="protein sequence ID" value="OEV34227"/>
        <property type="gene ID" value="HS99_0036840"/>
    </dbReference>
    <dbReference type="OMA" id="LESVHWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28124" checksum="6E720871AFA8B6CE" modified="2017-01-18" version="1">MLATPADNPYEEPRSGRLTAWGNALLSGLVPPDNAAAAVLGADEGHRVTGLPGDALGEQHGLTWALGRLRVLGVKGLRLALPSAGHPLGLTGPAVFNERAMAAGEAVLAVGVPLGLVPEVTVYGPEGDRSATVLWRCAEVNDAPPADVPSLHEAERELADGLREATALLTRLDVAGAGPEALRALEAYRRRGHTELLAPGYPPRAVRVLESARQVSALLAIASAGHGAAVSASEMAARQSVLAPLRRTARRAQVAAYNAQVDEREDGRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L4</accession>
    <name>A0A1E7N0L4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387007.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000614.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1949"/>
    <dbReference type="EnsemblBacteria" id="ARF79600">
        <property type="protein sequence ID" value="ARF79600"/>
        <property type="gene ID" value="B6264_12355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34211">
        <property type="protein sequence ID" value="OEV34211"/>
        <property type="gene ID" value="HS99_0037205"/>
    </dbReference>
    <dbReference type="OMA" id="NFAYGLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="28180" checksum="40344B5415EF7892" modified="2017-01-18" version="1">MTAKSEDTPPEHRTGTQPGIASPWNRPQKRRPQPALSREQIVAEAFALLDAEGIDALSMRKLGARLNAGATSLYTHVANKEELLALVVDHVFGELPLARAEGAEDPAVWRAVIVECTEGMRAAVVRHPWMVTVMGDVGMVYLGPNWMRLSEALLALMEAAGFGLAEANDVMGVVVGYTIGTASVEAAWLSALSRSGRGEQEFLDQLLPAVVEATRTHPRLHRLYTTQVPDEIEAGRDSGFLRGLNVILDGIEARRWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y0</accession>
    <name>A0A1E7N0Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0036405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6413"/>
    <dbReference type="EnsemblBacteria" id="OEV34347">
        <property type="protein sequence ID" value="OEV34347"/>
        <property type="gene ID" value="HS99_0036405"/>
    </dbReference>
    <dbReference type="OMA" id="IYYANAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="32898" checksum="F630E0D7960D5DB4" modified="2017-01-18" version="1">MDGLRTVRARHPWRWAAGAAALVVLVQFLHGLATNPAWDWATFRLYFTADTILQAIGRTLELTAYGTVLGFALGAVVAAMRLSRSAILRTLAWAYVWVFRSIPLIVQLVFWFNLSYLYKRFGFGIPFGPTFGDFETVGVLGALGAAVLGLGLHQAAFAAEIIRGGVIAVDAGQREAAAALGIPRGRQAWRIVLPQAMRSILPAAANEVISLLKGTSVVYVMAIGELFYQAQVIYGRTGRVVPLLMVATVWYVVLTTVLSIGQYYVERYFSRGARRTPPPTPLQRLRAFLRSLPARTSGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M4</accession>
    <name>A0A1E7N1M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000656.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7500"/>
    <dbReference type="EnsemblBacteria" id="ARF77532">
        <property type="protein sequence ID" value="ARF77532"/>
        <property type="gene ID" value="B6264_00065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34584">
        <property type="protein sequence ID" value="OEV34584"/>
        <property type="gene ID" value="HS99_0008765"/>
    </dbReference>
    <dbReference type="OMA" id="PGWRWLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="26175" checksum="130E0432103D163B" modified="2017-01-18" version="1">MTTVHRLGDHLVNFYLVDTGPALLLVDAGLPAHWDGLRTALRDLGRPVTDIAAVLVTHGHPDHVGVAEQVRAASGAEIWVHESDAPILTEPRRLNKVWTPERSLLGYAVRRPNSLRAPLHLARGGALRIPPVRSLRTFTHDRQLDLPGAPLAIHTPGHTHGSTSYLFPDASVAFTGDALVTHDAVAGRVGPCVICRAFTQDSTTALASLEKIAEHDIATVLPGHGEAWTDGLARAARQAVAGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U7</accession>
    <name>A0A1E7N1U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737936.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34680">
        <property type="protein sequence ID" value="OEV34680"/>
        <property type="gene ID" value="HS99_0009325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="518" mass="56476" checksum="9579D5B4EB1289BA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N212</accession>
    <name>A0A1E7N212_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0035485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279041.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7076"/>
    <dbReference type="EnsemblBacteria" id="OEV34503">
        <property type="protein sequence ID" value="OEV34503"/>
        <property type="gene ID" value="HS99_0035485"/>
    </dbReference>
    <dbReference type="OMA" id="MIPGIVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="28551" checksum="CD45623594B42823" modified="2017-01-18" version="1">MKRSPGRGGLLSALVGTVVLALMLFPVYWMVNASLQPAGNTLGGGWFPLHPDFSGYATALRDQGHNLVTSLVVALGSAALSLALAAPAAHALARFRLRGTNVVLLGILTTQTVPSIVVANALYGAYNDLGLLNSHLGLVLADSTAGVPFAIVILHSFMRGIPEEIIEAARVDGAGRLRVFRSVVLPLSRNALITAGVFTFLFAWSDFLFALTLTTTDTVRPITLGVYRYLGAHTNQWNAVMATTVLASLPAAVLLVVAQRHVTSAATGAAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N260</accession>
    <name>A0A1E7N260_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4582"/>
    <dbReference type="EnsemblBacteria" id="OEV34774">
        <property type="protein sequence ID" value="OEV34774"/>
        <property type="gene ID" value="HS99_0009855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24823" checksum="F8FE5A822CD0FF28" modified="2017-01-18" version="1">MRHGREHLLDVGRFHAAFVADARARGEACGPLDLLPGPELPAGGVVYRPAAELAYTAGTGDERQRQRAFVERHLPGVGPEETAAQLSACAALWEQPGPEGRGRAWERRRRSFPRLLIVLVGTAASGVRSAMADLHLADEENPTVAEALNQVLDQARSERMSVTAALERLLEIEVEATGARRMAAESGSPACRGPGPTGLGRARPRSRRSSSGKGTRGCRARAGRTGRRWAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A2</accession>
    <name>A0A1E7N2A2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3200"/>
    <dbReference type="EnsemblBacteria" id="OEV34828">
        <property type="protein sequence ID" value="OEV34828"/>
        <property type="gene ID" value="HS99_0010180"/>
    </dbReference>
    <dbReference type="OMA" id="FTSCLYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="699" mass="73968" checksum="D11FC7A1E2EFF485" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A9</accession>
    <name>A0A1E7N2A9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sacchrp_dh_NADP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558227.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7501"/>
    <dbReference type="EnsemblBacteria" id="OEV34583">
        <property type="protein sequence ID" value="OEV34583"/>
        <property type="gene ID" value="HS99_0008760"/>
    </dbReference>
    <dbReference type="OMA" id="TDCLAAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="31991" checksum="35BC1590F55E10D1" modified="2017-01-18" version="1">MVMRSDFVVLGASGTTGGLITEELVRRGRRVVLAGRNAARLARTAARFEAGAVSVLAVDLADPASLIAAAGAGRVLVNTVGPFARLAPPVVAACLDTGTAYLDLANERAAVRALLDRDAEARERDATLVTGAGFGPAATEALVLALLGTGVDATAVKVATAPHSAHDTDGVRGTVAEAMAEGATRYRAGELVRAPLGEGATTLTFGGAARTVIPVPVGDLEATREASGAPEVTAYAVPRGAGTDDGRSHAYAELTDADGRVHTAQLSTGEGFAFTTAVAVATATRLLDGPPPGAWTAARLLGAEPIASLPGTTIQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D9</accession>
    <name>A0A1E7N2D9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557729.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000168.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7598"/>
    <dbReference type="EnsemblBacteria" id="ARF81779">
        <property type="protein sequence ID" value="ARF81779"/>
        <property type="gene ID" value="B6264_25355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34859">
        <property type="protein sequence ID" value="OEV34859"/>
        <property type="gene ID" value="HS99_0010365"/>
    </dbReference>
    <dbReference type="OMA" id="QDNDPGE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32604" checksum="169C31FD771D7E4D" modified="2017-01-18" version="1">MQLDLNLLAALDALLEEGSVAGAAARLHVTAPAMSRSLGRIRRTTGDQILVRTGRTMTPTPYAIAVRERVHELLHQVQGVLAPSRELDLATLERTFTLRWHDSLVALSGPALLSAVHEEAPGVRLRFVAESSIDTPELRRAEVDLEANANRPSAPDIRAENVGETRLVIVVRQGHPLTRRRTVTVERYAAAEHVTVSRRGNLGNVVDDALARLGLTRRVVASAPTEAAALEFARGSDLLISVPEATTRSAVADLGLVVLPLPLELPSAPVYLSWHQRYDTDPAHAWLRGLARTALAMGGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2E6</accession>
    <name>A0A1E7N2E6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557743.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7609"/>
    <dbReference type="EnsemblBacteria" id="ARF81788">
        <property type="protein sequence ID" value="ARF81788"/>
        <property type="gene ID" value="B6264_25410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34850">
        <property type="protein sequence ID" value="OEV34850"/>
        <property type="gene ID" value="HS99_0010310"/>
    </dbReference>
    <dbReference type="OMA" id="SKESYWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="16174" checksum="FD5A70E18CB62EB8" modified="2017-01-18" version="1">MITHRDDGYELSVDPDRLDVVLVHHWLSTDAFWALGRSRETVEQSVRASLNFAVYETAGGAQVAYARVVTDWTTFAWLCDVYVAPAHRGKGLGTWMAGAVRDHLAPYRLKRVLLTTLDAHHVYAKAGFEPFPNPERLMILNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M8</accession>
    <name>A0A1E7N2M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554092.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5861"/>
    <dbReference type="EnsemblBacteria" id="ARF82520">
        <property type="protein sequence ID" value="ARF82520"/>
        <property type="gene ID" value="B6264_00175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34942">
        <property type="protein sequence ID" value="OEV34942"/>
        <property type="gene ID" value="HS99_0034920"/>
    </dbReference>
    <dbReference type="OMA" id="AWASGGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041261">
        <property type="entry name" value="R2K_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18299">
        <property type="entry name" value="R2K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="27764" checksum="B1B0565E38ADE3A3" modified="2017-01-18" version="1">MTTEAPVLLLAPRINETGLQLRTAAGLRGLRARTAASWRAPRELLGAPVHVYGGPLFADAVGRELGLALLEPAEDWLARLPRALTGRRVSATTLAEARALRGPAFVKPPADKLFAARVYLDGGALPGPELLDGDTPVLVSEVVRFRAEYRLFVLDGMVRAGSRYAVDGDLSVAPLGRDGSQVLAFARDVLAASAAQAPLPSAVVVDVGPTDHGWAVVEANAAWASGGYAAGPEDVLDVVLRSSGPATQLAGTDVPFLRELPEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q9</accession>
    <name>A0A1E7N2Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598989.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4567"/>
    <dbReference type="EnsemblBacteria" id="ARF78520">
        <property type="protein sequence ID" value="ARF78520"/>
        <property type="gene ID" value="B6264_05980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34977">
        <property type="protein sequence ID" value="OEV34977"/>
        <property type="gene ID" value="HS99_0034780"/>
    </dbReference>
    <dbReference type="OMA" id="RDRFGWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26490" checksum="CCF126224B82C8F4" modified="2017-01-18" version="1">MSAAPPDNDVLWARGIVKSHYGTPALRGISIGVREGEVLAVTGPRGSGKSTLLGCLSAQLPVDEGEVWFNSSPVHTLGRAGRERLRRDRFGFVGSEPHLVPELTARENVALPLLLAGAGHKAAYTAATEWLERLDVGDIARHRPDRLVQSQCQRIAVARALAPLPPVVFADDPTAPLHREAAEQVLRILTSAARSHQLTLVLATHDPELIRFADRAVGLVDGRITAPAAPVPRGTVAPAGASVVTATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2X3</accession>
    <name>A0A1E7N2X3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4709"/>
    <dbReference type="EnsemblBacteria" id="OEV35030">
        <property type="protein sequence ID" value="OEV35030"/>
        <property type="gene ID" value="HS99_0034420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="21054" checksum="E95A71C2DADECB9A" modified="2017-01-18" version="1">MPAREFVSAPALLLRSLLREPHRRAITTADGVEITAGDLAAATCRLAHELLARGVGRGATVTLLTGNTAEALSARYAAGLAGARVVNLYDGMSAPVLAEITASVETTVLLVDAERHAGAAELLPLIDVPTVLTLGPGPSGGAIGEDVIAASAHRPAEEPAVRIGPGDDLGIRHTGGTTALHLVDAIPLTAVGKPDRKRLREAVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N367</accession>
    <name>A0A1E7N367_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ORF">HS99_0033730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4446"/>
    <dbReference type="EnsemblBacteria" id="OEV35149">
        <property type="protein sequence ID" value="OEV35149"/>
        <property type="gene ID" value="HS99_0033730"/>
    </dbReference>
    <dbReference type="OMA" id="QIPVTKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="316"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="395"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="484"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="549" mass="58975" checksum="D0C79C6A09C9060B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N458</accession>
    <name>A0A1E7N458_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278143.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5552"/>
    <dbReference type="EnsemblBacteria" id="ARF79364">
        <property type="protein sequence ID" value="ARF79364"/>
        <property type="gene ID" value="B6264_10905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35478">
        <property type="protein sequence ID" value="OEV35478"/>
        <property type="gene ID" value="HS99_0031710"/>
    </dbReference>
    <dbReference type="OMA" id="NKEVVRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="25322" checksum="A961710F89E57459" modified="2017-01-18" version="1">MRSLPVRRTAAVALTAAASVVALAGPAFAHVTVNPGSAAQGGYATVNFQVPDESDTASTVKLEVSLPLDHPLASVRTMPMPGWTATVEKSKLDKPIKVHGSDVNEAVSKITWTADANTKIAPGQFGEFKLSLGPLPADADSMVFKALQTYDNGDVVRWIDEAQAGQPEPAHPAPTLKLTKAASGDGHGVTASASPAAGAHADSSDQAASSGDAKSGDGTARTLGVVGIVVGVIGTAVGVLGLRRRNGGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N461</accession>
    <name>A0A1E7N461_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289510.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000384.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6135"/>
    <dbReference type="EnsemblBacteria" id="ARF79306">
        <property type="protein sequence ID" value="ARF79306"/>
        <property type="gene ID" value="B6264_10600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35243">
        <property type="protein sequence ID" value="OEV35243"/>
        <property type="gene ID" value="HS99_0033565"/>
    </dbReference>
    <dbReference type="OMA" id="PRKWAAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7561" checksum="F1154A6FB7EEAADC" modified="2017-01-18" version="1">MSTWRKASASGESTDCVEVRSAGGLVEIRESDLPEVVVRTTPRKWAAFVRGVKAGEFDRYADFTRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4B7</accession>
    <name>A0A1E7N4B7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Bacterioferritin</fullName>
            <ecNumber evidence="5">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0033135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the bacterioferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000321.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5320"/>
    <dbReference type="EnsemblBacteria" id="ARF80728">
        <property type="protein sequence ID" value="ARF80728"/>
        <property type="gene ID" value="B6264_19075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35303">
        <property type="protein sequence ID" value="OEV35303"/>
        <property type="gene ID" value="HS99_0033135"/>
    </dbReference>
    <dbReference type="OMA" id="YQRLFHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="18672" checksum="4167A6B262AED43B" modified="2017-01-18" version="1">MQGDPEVIEFLNEQLTAELTAINQYFLHAKMQENFGWTKLAKYTRHESFDEMKHAETLTDRILFLEGLPNYQRLFHVRIGQTVKEMFEADRQIEVEAIDRLKRGIVMMRAKNDVTSANIFEDILADEEHHIDYLDTQLELLDKLGEALYIAQQIEQPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4G9</accession>
    <name>A0A1E7N4G9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0006450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000264.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5348"/>
    <dbReference type="EnsemblBacteria" id="ARF80753">
        <property type="protein sequence ID" value="ARF80753"/>
        <property type="gene ID" value="B6264_19215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35562">
        <property type="protein sequence ID" value="OEV35562"/>
        <property type="gene ID" value="HS99_0006450"/>
    </dbReference>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="446" mass="47309" checksum="ECF13B023A5D6E59" modified="2017-01-18" version="1">MTKQDAAEPWRVISATTTKYKSAGPLGRLRAFRARVRYWLDRPLTPYLLVVGTTLLLVVLGLMMVFSASQILALNQHHTAQYYFLKQLIAAILGLVLLIGFASVPVAVLRVIVYPVMFGVIGALALVAVPGIGVRINGNQNWLDFGFFQFQPSEFAKLALVLWGADLLARKQKAGTLTSWKHLLVPLVPGALLLLALIMIGGDMGTSMILVAMVFALLWMVGAPLRLFVATLGVAVVVCTALVITVPHRAERLGCIGVTKLDPEGACFQALHGVYSFALGGGFGTGLGAGVEKWGQLPEAHTDFIFAATGEELGLVGTLSVIGLFAALGYAGIRVAIGTKDPFVRYAAGAATTWIMAQAMINLGSALGLLPIAGVPLPLFSYGGSAMLSAMSAIGVLLCLARSSSGAKAALAARSKNSRIRKRLARVLPRRRTTARPAPGPARRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M7</accession>
    <name>A0A1E7N4M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387154.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene933"/>
    <dbReference type="EnsemblBacteria" id="OEV35646">
        <property type="protein sequence ID" value="OEV35646"/>
        <property type="gene ID" value="HS99_0006965"/>
    </dbReference>
    <dbReference type="OMA" id="TPWTYAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="17558" checksum="DA99D5AC71F73490" modified="2017-01-18" version="1">MTRQPDPLTPPRTAAYIRLVRSSAWYDLVVTAGFATPWTYALLHGALSSLSARFGLGTLPALNPFQTLYANLMGSVVIVWALLRIIQPLPLHGLLDGIARTLFASWQAYALAHGATRVLWFFFVLEATFGVVQLLPWWRDRAALLASVRRNDPEPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P3</accession>
    <name>A0A1E7N4P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281788.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene924"/>
    <dbReference type="EnsemblBacteria" id="OEV35655">
        <property type="protein sequence ID" value="OEV35655"/>
        <property type="gene ID" value="HS99_0007010"/>
    </dbReference>
    <dbReference type="OMA" id="FEHEITF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="19924" checksum="0837173B1944AAD1" modified="2017-01-18" version="1">MAAAPTLEELLRGCTRSALHLEMRDGYMRDDPLFLRWLSGRRDDPTDRSSWWSPWLQLIKETTARGVDVRRARIISEPPSEYIRFEHEITFRNIASGEQVRWLPRRQATDLALPGNDFWLIDGQHLLIHHFSGEGDFVEHEFNAAPQTVSLCASAFEAVWARAVPHQDFRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z3</accession>
    <name>A0A1E7N4Z3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene782"/>
    <dbReference type="EnsemblBacteria" id="OEV35760">
        <property type="protein sequence ID" value="OEV35760"/>
        <property type="gene ID" value="HS99_0007730"/>
    </dbReference>
    <dbReference type="OMA" id="FWNLGYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="19799" checksum="222DBF4E45F99B04" modified="2017-01-18" version="1">MTTAEQAVVTGRTIVAVSERLVLTRPQEGDAEAMFAIHGDPETNRYNPDGPQRDIAQAREQLAGFVADWPRDGVGYCMVSTREEPEVVIGVAGLFLHSLDGEPVFNLYYRFRPSAWGKGYAAEACRAAMAEALPRFPGIPVTALIREDNLPSRRLAGRLGLVADPDGRVDHEDRLIHRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C1</accession>
    <name>A0A1E7N5C1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286200.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7263"/>
    <dbReference type="EnsemblBacteria" id="ARF81096">
        <property type="protein sequence ID" value="ARF81096"/>
        <property type="gene ID" value="B6264_21250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35885">
        <property type="protein sequence ID" value="OEV35885"/>
        <property type="gene ID" value="HS99_0008475"/>
    </dbReference>
    <dbReference type="OMA" id="KMRAMEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="13441" checksum="FEC792ECB5199D98" modified="2017-01-18" version="1">MANLEMSLKEAMAIDGAIGVALVDYGSGMALGSLGDGGEMDLNVAAAGNTDVVRAKMRAMEMLNLHDNEIEDILISLTNQYHLVRPITTPSGRGLFLFLALNRSRSNLAMARHQLKRIELSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J6</accession>
    <name>A0A1E7N5J6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7295"/>
    <dbReference type="EnsemblBacteria" id="ARF81126">
        <property type="protein sequence ID" value="ARF81126"/>
        <property type="gene ID" value="B6264_21410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35914">
        <property type="protein sequence ID" value="OEV35914"/>
        <property type="gene ID" value="HS99_0008635"/>
    </dbReference>
    <dbReference type="OMA" id="YRDKVGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14328" checksum="4129F6F46F594DA9" modified="2017-01-18" version="1">MDWKLEVVVVPVADVDRAKLFYEEQAGFTVDHDTRLRDGIRVVQLTPPGSHCSIVVGTGVIDAAPGSVKGLQLVVADIEKAHAELAARGVEVSPVQHFVAGTRVDGHGETWNNFVFFNDPDGNGWAVQEAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M4</accession>
    <name>A0A1E7N5M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551184.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene938"/>
    <dbReference type="EnsemblBacteria" id="ARF82940">
        <property type="protein sequence ID" value="ARF82940"/>
        <property type="gene ID" value="B6264_19710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35944">
        <property type="protein sequence ID" value="OEV35944"/>
        <property type="gene ID" value="HS99_0006940"/>
    </dbReference>
    <dbReference type="OMA" id="VDARWID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30171" checksum="C151F9C1F4ABF1BA" modified="2017-01-18" version="1">MDPQQLRTFATVTRLASFSEAARELGYTQSAVSQQIAALEADLGTALLVRRPVGPTVAGRRLLEHAVPLLVRLEAARADVARLAGSPSARLVLGATPLAVGVALGRALGEVRRAYPQVEPVVRVLAQDVLAARVATGEVDLALIDGLAAPSDPLPLPEVGPLTTVAVDERPVAVALPAGHPLAGRAGLALSDLSAARWLDAPDLTPTADRLRAAAGTDGFRPATRYRGTDLHGLLALVATGHGLTLLPEPVVAGAPGVDHAPVAAPRLVHRTELVHGSLPEGPAALLARLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5T9</accession>
    <name>A0A1E7N5T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene484"/>
    <dbReference type="EnsemblBacteria" id="OEV36060">
        <property type="protein sequence ID" value="OEV36060"/>
        <property type="gene ID" value="HS99_0031330"/>
    </dbReference>
    <dbReference type="OMA" id="IVWMTVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="19503" checksum="2996F3F70AACF1C6" modified="2017-01-18" version="1">METSPITGSNRVRLDQPRTARPGLLTLPSYDPEAFGVLSERIARFLGTGRFIVWMTVVIVVWVLWNTMLPPAARFDEYPFIFLTLVLSLQASYAAPLILLAQNRQDNRDRVNMEQDRARSDRNIADTEYLAREVAALRHGLGEVATRDFIRSELQSLLKEIDERRDAAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E8</accession>
    <name>A0A1E7N6E8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="4" type="ORF">HS99_0030755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551587.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8049"/>
    <dbReference type="EnsemblBacteria" id="ARF79836">
        <property type="protein sequence ID" value="ARF79836"/>
        <property type="gene ID" value="B6264_13810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36224">
        <property type="protein sequence ID" value="OEV36224"/>
        <property type="gene ID" value="HS99_0030755"/>
    </dbReference>
    <dbReference type="OMA" id="RTWRCAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14336" checksum="EBBFFE4DD8B3D5FD" modified="2017-01-18" version="1">MPADIPADLKYTRDHEWVLLQGKTARVGITNYAQRQLGDIVFVELPKEKDKFDRGQPFGTVESVKSVSELYAPLSGTVAAVNQDLNEAPEDINGDPYGDGWMIELTLTSADELKDLLTAAEYEGYLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G7</accession>
    <name>A0A1E7N6G7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386322.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000315.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2653"/>
    <dbReference type="EnsemblBacteria" id="OEV36268">
        <property type="protein sequence ID" value="OEV36268"/>
        <property type="gene ID" value="HS99_0030125"/>
    </dbReference>
    <dbReference type="OMA" id="IRAMFFI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="22490" checksum="4374286A1927289A" modified="2017-01-18" version="1">MPTHDDLAARATGPQDAPPRRTQAERRAHAERALLAAAARLIAEHGSTGVTLARVGEEAGFSRGLATHYFGSKAALLARLQEEALAEAMAAAAPERSGAGAAEELCRFARGCLEGVRNPTDLGRAFVVLGAEALAGASELTAAVAELDERTRGWAAEVVGQGLAEGQVRAGVDARAFAFAFVGLLKGLVVQAAAAPGAFDVTAATTEAERWIRLALPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X7</accession>
    <name>A0A1E7N6X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SARP family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0029425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554215.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene200"/>
    <dbReference type="EnsemblBacteria" id="OEV36457">
        <property type="protein sequence ID" value="OEV36457"/>
        <property type="gene ID" value="HS99_0029425"/>
    </dbReference>
    <dbReference type="OMA" id="DWGPYRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="644" mass="68104" checksum="7D016442EA8F036C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y5</accession>
    <name>A0A1E7N6Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554247.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene227"/>
    <dbReference type="EnsemblBacteria" id="ARF82257">
        <property type="protein sequence ID" value="ARF82257"/>
        <property type="gene ID" value="B6264_28310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36438">
        <property type="protein sequence ID" value="OEV36438"/>
        <property type="gene ID" value="HS99_0029305"/>
    </dbReference>
    <dbReference type="OMA" id="KGEMKWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="29611" checksum="515CBC87FCD6860C" modified="2017-01-18" version="1">MSALDFEIIDAPDSSLNKTAVLVSGPNNALLVDAGFTRSDGRRLVERVRATGKELTTVFVSHGDPDFYFGAQEVQDAFPRARFLATASTVEHIQETFEEKLRAWAHLGPELPTRLVRPEVLPGDELVFEGHRFELRGADFHLPDRHYLWQHHHRAVLGGVLLFEGLHVWTADTPTAAQRTAWIDLLDGMEALHPTWVAAGHRVADAPTDLNAIDHTRAYLRAFETELGRSADAAAAKEALERRFPELGLRIAVDIGTKVAKGEMAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N718</accession>
    <name>A0A1E7N718_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1488"/>
    <dbReference type="EnsemblBacteria" id="ARF79202">
        <property type="protein sequence ID" value="ARF79202"/>
        <property type="gene ID" value="B6264_09965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36496">
        <property type="protein sequence ID" value="OEV36496"/>
        <property type="gene ID" value="HS99_0028615"/>
    </dbReference>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="28074" checksum="71799FB95381D036" modified="2017-01-18" version="1">MAKRIDVSGLSAYYGTTKAIEDISMSIEPRSVTAFIGPSGCGKSTFLRTLNRMHEVIPGARVEGKVLLDDENLYASNVDPVAVRRSIGMVFQRPNPFPTMSIYDNVVAGLRLAGVKKKSVLDDVVERSLKGANLWKEVHNRLNKPGAGLSGGQQQRLCIARAIAVEPQVLLMDEPCSALDPISTLAIEDLIGELKSQFTIVIVTHNMQQAARVSDRTAFFNLAGVGQPGKLIELDDTQRIFSNPSVQATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N754</accession>
    <name>A0A1E7N754_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555396.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1477"/>
    <dbReference type="EnsemblBacteria" id="ARF79194">
        <property type="protein sequence ID" value="ARF79194"/>
        <property type="gene ID" value="B6264_09910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36505">
        <property type="protein sequence ID" value="OEV36505"/>
        <property type="gene ID" value="HS99_0028670"/>
    </dbReference>
    <dbReference type="OMA" id="ASAMIYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="42778" checksum="F5CB79D623FC9294" modified="2017-01-18" version="1">MPVDQTARRSTARRAGTVAGALAALQVATMLAAQRVFADPSPTATPTCQKVDLPIPGSDAGCAPNGAVVIPGSGTVGTVTDPLGSLAKGCAQAAAWVVRKLSGAIDGTTAVDFTNQSFLQQYAVVFAVSTVITLVLWLLAVTKRAVRGAPLTTAISEAVGFLWLTVVASAFTPLILFTVVSVTDGLTKAIAVGTKSDTGTYLSGFADTLEKGDVGGGPLILVIVSLVAVLAAAVLWIELVIRAAMLYVGALLGTAVYAGLVDRQLWKHVRRWAGMMLAVDLAKPIIVIILGLAGAVATGAGANDDFARVLSGLAILFLSIFASAAVYRFVPTFGDEMLNMRRARASAVQAGSAMINGTANLMKQGISTHGDRGPQAAGGGGGAGGGSVAPGIAAHAGRTPAPPPQAGPPQAPVPIRDSNPAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B0</accession>
    <name>A0A1E7N7B0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386929.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1492"/>
    <dbReference type="EnsemblBacteria" id="OEV36592">
        <property type="protein sequence ID" value="OEV36592"/>
        <property type="gene ID" value="HS99_0028595"/>
    </dbReference>
    <dbReference type="OMA" id="DWSHPKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="18155" checksum="198DDCE6B079F998" modified="2017-01-18" version="1">MDAPATGTGRAPVVLAAGAVLWLPGKPKPSGRLGRPRIAVIHRPKYDDWSLPKGKLDPGEGVVEAALREVAEETGFRCLLGPELPAQHYLAQGRPKEVRYWAAVPTGGAFRPNREVDRLEWLPAGKARARLTHDRDRLLVDALLAVLGAKPVRTGEEPRVRERWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D3</accession>
    <name>A0A1E7N7D3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactate utilization protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554784.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7736"/>
    <dbReference type="EnsemblBacteria" id="ARF83130">
        <property type="protein sequence ID" value="ARF83130"/>
        <property type="gene ID" value="B6264_28710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36383">
        <property type="protein sequence ID" value="OEV36383"/>
        <property type="gene ID" value="HS99_0029955"/>
    </dbReference>
    <dbReference type="OMA" id="VPDHHIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22341" checksum="1EA432C27D768C5D" modified="2017-01-18" version="1">MTSRDLILGRIRAALGDTGTVAEQPLPRRYLSAHAPADDPAALLDLLHRNLTDYRALVHRCTEAELPSRIAELLAARGSRTVAVPAGLPDGWLTAAVGVEPLPDDGSLTAARLDAVDSVVTGCALAVAETGTIVLDGGPGQGRRLLSLVPDHHLCVVRAPEQVVASVPLALPRLDPARPQTWISGPSATSDIELDRVVGVHGPRTLEVLLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L6</accession>
    <name>A0A1E7N7L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0028070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2553"/>
    <dbReference type="EnsemblBacteria" id="OEV36634">
        <property type="protein sequence ID" value="OEV36634"/>
        <property type="gene ID" value="HS99_0028070"/>
    </dbReference>
    <dbReference type="OMA" id="FDTGWRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="157"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="40284" checksum="689817B5A03F3774" modified="2017-01-18" version="1">MKDLLLIALFAALGAGGAGLLGWAAVRLLRRRSLALALFCVAAVTVLAVTSGTFAVAQAMFLSRHDLGVVITVLVMASVVSLATAALLGRQVVAGGRALTVAARTVGSDTGFTAPEPPLGLELAQLSEELAATSARLAESRARAQALDTSRRELIAWISHDLRTPLAGLRAMAEALEDGVAEHPQRYLQRMRTEVERLTGMVDDLFELSRIQAGALALSLSRVSVYDLVDDALAGAHPLARKRGVRLEGRQVAAEPVEVDSGEITRVLGNLLVNAIRSTPEDGVVAVSARREADEVVLSVTDGCGGIPEQDLPRVFETGWRGSAARTPRPADQANPRRPSEGGGSGAGLGLAIVRGIVEAHAGRARVRNVAGGCCFEIVLPAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N0</accession>
    <name>A0A1E7N7N0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Daunorubicin resistance protein DrrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278853.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2495"/>
    <dbReference type="EnsemblBacteria" id="ARF81506">
        <property type="protein sequence ID" value="ARF81506"/>
        <property type="gene ID" value="B6264_23640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36679">
        <property type="protein sequence ID" value="OEV36679"/>
        <property type="gene ID" value="HS99_0028355"/>
    </dbReference>
    <dbReference type="OMA" id="VCFEGTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="515"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="787" mass="83678" checksum="7F70CA8BBC744171" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N6</accession>
    <name>A0A1E7N7N6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0028235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550738.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2520"/>
    <dbReference type="EnsemblBacteria" id="OEV36717">
        <property type="protein sequence ID" value="OEV36717"/>
        <property type="gene ID" value="HS99_0028235"/>
    </dbReference>
    <dbReference type="OMA" id="HKMERIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198937" description="Histidine kinase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="178"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="239"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="47668" checksum="28ADE955A9171141" modified="2017-01-18" version="1">MRRFVPRTVRARATAAAGTVLAAALALAGAGLLAAVHADLVASAASATRQQAESVAQLAVQGRLVPVLHPAHGTDFLQVVDARGTVLAASPNLAGRPALATARRTGSHTTDDVDPLYDHHRQRLAAVTADTPDGPVTVYAGASLRAADEAMDITQAGLAVACPLLLLTGVVVTWKVTGQALRPVEAIRAEVDAITGQDLHRRVPEPGTADEIARLAATMNAMLDRLEASGRRQRQFIADASHELRSPLAVLRTQLEVADTHPDPAVRAELVHGALADTDRLQNLATDLLLLARLDAGGTDDRPRHRIDLTDLVATTVLARPSGPHRRTTDLAPGVTVDGIPLWLGRLLTNLLDNADRHAATTVHVRLGTDPARGLALLDVEDDGPGIPPADRERVFERFTRLDDARSRDHGGTGLGLSIARDIARHHHGTLAVTPTPTGARLTATIPLTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R2</accession>
    <name>A0A1E7N7R2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027375</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4763"/>
    <dbReference type="EnsemblBacteria" id="OEV36742">
        <property type="protein sequence ID" value="OEV36742"/>
        <property type="gene ID" value="HS99_0027375"/>
    </dbReference>
    <dbReference type="OMA" id="WEKWVFL"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="178"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30473" checksum="C8AAB8D069F082F7" modified="2017-01-18" version="1">MTTTPLTVAVLGPGGVGGLIGGLLARDGHRVICLAGERTAAALARDGLHVRSGQFGEFTARVEAATELREPVDAAFVTVKETALAAALDRMPPQALGTGIVVPLLNGLDHMALLREHYPAGRVVAGTIRVEATRTAPGRIEHTSPFATIELAAPVEEFAEQLRRTGLDVTLREDETAMLWSKLSFLAPFALLTTRHADGIGAVRTEHRGELLAVLDEIAAVTKAVGAPADARTLLASFDRIPGAMKSSMQRDVEAGRPTELDAIGGAVLRAAAAHSVPTPTITRLVRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N868</accession>
    <name>A0A1E7N868_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737839.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6464"/>
    <dbReference type="EnsemblBacteria" id="OEV36881">
        <property type="protein sequence ID" value="OEV36881"/>
        <property type="gene ID" value="HS99_0026815"/>
    </dbReference>
    <dbReference type="OMA" id="DQHANSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1510"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="874"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1553" mass="167367" checksum="8F8D0404CD1E1B19" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N890</accession>
    <name>A0A1E7N890_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0026865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281983.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000123.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6475"/>
    <dbReference type="EnsemblBacteria" id="ARF78663">
        <property type="protein sequence ID" value="ARF78663"/>
        <property type="gene ID" value="B6264_06820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36889">
        <property type="protein sequence ID" value="OEV36889"/>
        <property type="gene ID" value="HS99_0026865"/>
    </dbReference>
    <dbReference type="OMA" id="QLYWTAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015064099" description="Neutral metalloproteinase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="10">
        <location>
            <begin position="64"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="218"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="367"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="542" mass="55985" checksum="1F326017759602F2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C3</accession>
    <name>A0A1E7N8C3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000372.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6493"/>
    <dbReference type="EnsemblBacteria" id="ARF78647">
        <property type="protein sequence ID" value="ARF78647"/>
        <property type="gene ID" value="B6264_06730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36904">
        <property type="protein sequence ID" value="OEV36904"/>
        <property type="gene ID" value="HS99_0026955"/>
    </dbReference>
    <dbReference type="OMA" id="RYFEVMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="611" mass="66097" checksum="6B986ADBCA643032" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M8</accession>
    <name>A0A1E7N8M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556166.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7462"/>
    <dbReference type="EnsemblBacteria" id="ARF81687">
        <property type="protein sequence ID" value="ARF81687"/>
        <property type="gene ID" value="B6264_24780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37041">
        <property type="protein sequence ID" value="OEV37041"/>
        <property type="gene ID" value="HS99_0004225"/>
    </dbReference>
    <dbReference type="OMA" id="FLCMDLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="21756" checksum="4951C59F456C9E2A" modified="2017-01-18" version="1">MEVTVAGRPRGVDDAVILRAAAEVMGRVGPAGLTLAAVAREVGLVPGTLIQRFGSKSGLLVALAEQSAKDADALPERVRAEHETALGALAALVVRWLAPMDTPERFANHLAFLCTDLADPQLYEPALAAHLAQRRAIESLLAEAVAAGELNAGTNVAVLAGSVQAITAGAGLVWALERRGALAQRLRHELRAVLTPHMPPGHDDLEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z5</accession>
    <name>A0A1E7N8Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketosteroid isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556660.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6221"/>
    <dbReference type="EnsemblBacteria" id="ARF81573">
        <property type="protein sequence ID" value="ARF81573"/>
        <property type="gene ID" value="B6264_24085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37161">
        <property type="protein sequence ID" value="OEV37161"/>
        <property type="gene ID" value="HS99_0004905"/>
    </dbReference>
    <dbReference type="OMA" id="RPFYWDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16223" checksum="4F30950AB160EE77" modified="2017-01-18" version="1">MTRSSATESVRVLTGMYAAEAQYFAAGGPGEASFDLLAPFFAPDVELHQAAALPYGGIWRGHAGMTRFFLTMGQVWESFDMVEQEFLATGETAVVLTQVRARARATGRVLNFPVLQTITVKGGRITEVRPFYWDTRAIADACAAPSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM1</accession>
    <name>A0A1E7NAM1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280851.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1631"/>
    <dbReference type="EnsemblBacteria" id="ARF79975">
        <property type="protein sequence ID" value="ARF79975"/>
        <property type="gene ID" value="B6264_14605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37718">
        <property type="protein sequence ID" value="OEV37718"/>
        <property type="gene ID" value="HS99_0025815"/>
    </dbReference>
    <dbReference type="OMA" id="FATDDYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="34180" checksum="419B2832917BBEC3" modified="2017-01-18" version="1">MIEARHLRVLRAVARTGSFSAAARELGCTQPAISQQMKALEKSVDTPLVVRSGRGMQLSEAGRVLLKHATGILAGLSAAEEEVAAIAGLRAGRVRLVSFPTASSTLVPPAVARLRDSHPGVRVSLVEAEPPESLAMLRGGECEIALAFRYPQSDGATASPAAAHGSPREARAEANLEAQQLSAGTDWSDLVVTPLLDDPLVGLLPAGHPLAGRGGPVGLAELAGEQWIAGCPQCRGHLVELCAGAGFEPRIDFATDDYPAVVGLVAAGLGVAVLPRLALQSVRPDGVSTVPVRTASGVPAVRQVVALTLPDLAEVPAVALMQERLAGAAAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU7</accession>
    <name>A0A1E7NAU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386740.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000481.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene8002"/>
    <dbReference type="EnsemblBacteria" id="ARF82715">
        <property type="protein sequence ID" value="ARF82715"/>
        <property type="gene ID" value="B6264_09060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37593">
        <property type="protein sequence ID" value="OEV37593"/>
        <property type="gene ID" value="HS99_0026295"/>
    </dbReference>
    <dbReference type="OMA" id="PGWGTVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16921" checksum="C998AB0BB8FC9E96" modified="2017-01-18" version="1">MAAKAAVLSTVPSGVWRIVFGFGVPVGFTGATAAAFGAHQPGWGTVYCVVLSALAEALAFLTLGLVRPWGLVAPRWIPLIGGRRVRPLAAIVPALLGSAILTALGMEGLFGRWAHNLAEPDAPHGFAGLVMTAAYLPLVAWGPLLGAVTLDYARRTLWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA3</accession>
    <name>A0A1E7NBA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278365.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000348.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79526">
        <property type="protein sequence ID" value="ARF79526"/>
        <property type="gene ID" value="B6264_11910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37972">
        <property type="protein sequence ID" value="OEV37972"/>
        <property type="gene ID" value="HS99_0024235"/>
    </dbReference>
    <dbReference type="OMA" id="CCPRVST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10535" checksum="7DB70254773BBE80" modified="2017-01-18" version="1">MERTVTAEGASLGTLLRNIRLDRGMTQEQLGEASGLSVRSIRDLERGVCCPRVSTLRLLTQTWNLPAPQGAELHRLARAWRDRSRRQRRAVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBN1</accession>
    <name>A0A1E7NBN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556817.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000388.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79689">
        <property type="protein sequence ID" value="ARF79689"/>
        <property type="gene ID" value="B6264_12940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38102">
        <property type="protein sequence ID" value="OEV38102"/>
        <property type="gene ID" value="HS99_0023160"/>
    </dbReference>
    <dbReference type="OMA" id="DHEDYLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="7328" checksum="823874E58E3F9033" modified="2017-01-18" version="1">MPQDHEDYLIDETVETVEPDEEVTSDEYDEVAERRALGADPATDVADAAEQNRIVQLDEDDYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBQ6</accession>
    <name>A0A1E7NBQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000540.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5941"/>
    <dbReference type="EnsemblBacteria" id="ARF79675">
        <property type="protein sequence ID" value="ARF79675"/>
        <property type="gene ID" value="B6264_12860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38117">
        <property type="protein sequence ID" value="OEV38117"/>
        <property type="gene ID" value="HS99_0023245"/>
    </dbReference>
    <dbReference type="OMA" id="VAENDAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16042" checksum="42B592539A205E12" modified="2017-01-18" version="1">MDTTTAAVSGLVLALFGGVLLLWCAAEVRLRHWVRRRGVSAVATVVAENDAHGQLDSAPLLSFSVLSPEGCADRSGAGRIAELVLTRPRGHTPLRRPERFAPGAPVRICYDPDRPCRAVLAAGEAGRAAAVDLLWGALGAACLVAGAGLLAALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBV4</accession>
    <name>A0A1E7NBV4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Colicin V synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288103.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7150"/>
    <dbReference type="EnsemblBacteria" id="ARF79657">
        <property type="protein sequence ID" value="ARF79657"/>
        <property type="gene ID" value="B6264_12735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38134">
        <property type="protein sequence ID" value="OEV38134"/>
        <property type="gene ID" value="HS99_0023360"/>
    </dbReference>
    <dbReference type="OMA" id="YRQGFVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="40974" checksum="B154D6B0EEB0F1EB" modified="2017-01-18" version="1">MNVLDVLLILAAVGFAVSGYRQGFVVGVLSLVGFLGGGLLAVQLLPLLLDHLSPGTTASVVAVVVVIVCAAIGQAVTAHFGWKLRGHIDRRPARLLDASGGAVVNVISMLLVAWLIGSALAGTSLPTVSKQVRTSAILGGVQDALPGDAPNWFSDFSKVLARNGFPQVFNPFEHEPITQVDTPDPALANSPAVAKARQSLVKVVGTATSCGKTLEGSGFVFAPHRVMTNAHVVGGVDEPTVQIGGVGQLYDATVVRYDWQRDIAVLDVPKLNAPPLTFAGEARTNDSAIVAGFPENGAFNVQPARIRGRIQANGPDIYHRGQVVRDVYSVRSLVRQGNSGGPLLTPDGQVYGVVFAKSLDSADTGYVLTSAEVREDATAGGSASARVDTQGCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC05</accession>
    <name>A0A1E7NC05_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3309"/>
    <dbReference type="EnsemblBacteria" id="ARF80273">
        <property type="protein sequence ID" value="ARF80273"/>
        <property type="gene ID" value="B6264_16360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38217">
        <property type="protein sequence ID" value="OEV38217"/>
        <property type="gene ID" value="HS99_0021920"/>
    </dbReference>
    <dbReference type="OMA" id="GYTRMAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="542" mass="55547" checksum="A830107611C2A11E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE5</accession>
    <name>A0A1E7NCE5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553240.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000359.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4134"/>
    <dbReference type="EnsemblBacteria" id="ARF82854">
        <property type="protein sequence ID" value="ARF82854"/>
        <property type="gene ID" value="B6264_15585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38369">
        <property type="protein sequence ID" value="OEV38369"/>
        <property type="gene ID" value="HS99_0022690"/>
    </dbReference>
    <dbReference type="OMA" id="HAVYANY"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="541" mass="58655" checksum="2ED8EF4F72B5B923" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND09</accession>
    <name>A0A1E7ND09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000516.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3943"/>
    <dbReference type="EnsemblBacteria" id="OEV38373">
        <property type="protein sequence ID" value="OEV38373"/>
        <property type="gene ID" value="HS99_0020875"/>
    </dbReference>
    <dbReference type="OMA" id="AMQPHRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199014" evidence="3">
        <location>
            <begin position="27"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="417"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="522" mass="53623" checksum="C81EF4CADFDF9CDC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND66</accession>
    <name>A0A1E7ND66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366437.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000478.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38627">
        <property type="protein sequence ID" value="OEV38627"/>
        <property type="gene ID" value="HS99_0020425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10840" checksum="DCE31655736154FA" modified="2017-01-18" version="1">MEFVAGPPARWHLTLKDGTLLELWADGYGIVNGAYEFSALVRATEEEQGQAHVLARTPSDSHRVMVAVARLATGSVQDVHTASRPSHDGACVCPGLPGSSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND89</accession>
    <name>A0A1E7ND89_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Malate synthase</fullName>
            <ecNumber evidence="2 6">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0020725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 6"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282990.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000496.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1798"/>
    <dbReference type="EnsemblBacteria" id="ARF77711">
        <property type="protein sequence ID" value="ARF77711"/>
        <property type="gene ID" value="B6264_01140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38676">
        <property type="protein sequence ID" value="OEV38676"/>
        <property type="gene ID" value="HS99_0020725"/>
    </dbReference>
    <dbReference type="OMA" id="CHKRGAP"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="550" mass="59611" checksum="15ABE4C5B0D97A2D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC5</accession>
    <name>A0A1E7NDC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1817"/>
    <dbReference type="EnsemblBacteria" id="ARF77727">
        <property type="protein sequence ID" value="ARF77727"/>
        <property type="gene ID" value="B6264_01230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38687">
        <property type="protein sequence ID" value="OEV38687"/>
        <property type="gene ID" value="HS99_0020815"/>
    </dbReference>
    <dbReference type="OMA" id="ANCGIRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="39388" checksum="B1B392BD7257B66E" modified="2017-01-18" version="1">MSMSTRLCALAASVALLTALAVPAAAADPGAAAGSGAPTVNLATNPGFELPSPNLADWGSVPGWNCTGGPAEAAVTTTAAHSGTSALTVTPANADSTGECAQTVDVQPDTTYTASAWVRGNFVHLGATGTGHDVAPAWTATTSGGWQQLTTRFTTGPNARSIRLYVHGWYQQGPFSVDDVRVDGPAPAPAVAAGSIPTTDKVVFFTVDDGWQRTPEAERFIADHHLPITAFPLPMPAGTDPDFFKRVTAVPGSSVQDHSVSHSDLSKLPLEQQQVEICDARDTMTRLFGTAPVVFRPPFFTWNTDTLQAAANCGIRTVLTADADFSWGASNIWHPGLLQPGDVVLMHWTDALAADLPRALAAAEAAGLKPAGLVDYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE9</accession>
    <name>A0A1E7NDE9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
            <shortName evidence="3">Pol IV</shortName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dinB</name>
        <name evidence="6" type="ORF">HS99_0021740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555008.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3109"/>
    <dbReference type="EnsemblBacteria" id="OEV38513">
        <property type="protein sequence ID" value="OEV38513"/>
        <property type="gene ID" value="HS99_0021740"/>
    </dbReference>
    <dbReference type="OMA" id="KVRRYDF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="3">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="49329" checksum="A7D0D4E89C1FD991" modified="2017-01-18" version="1">MRSLPSIIHLDMDAFFAAVEQAAKPSLRGKPVIVGGLGGRGVVSTASYEARRFGVHSAMPMAQARRLCPNAAFLTGRFEAYRQNSEIVMGLLRELSPLVQPLSLDEAFVDLEAGPYGPVLAETDHETGERLVLAVAEDLRADIQRRTGLTGSVGAAGSKLMAKIASEQAKPDGLVLIEPGRERAVLGPMPVRALPGIGPATEQVLRRAGLSTVADLADAGEAELVQLLGRAHGAGIHQMSIGLDERPVVADQDAKSVSVEDTYEVDLADRDRVLREVEALAGRCVRRLRAAGRSGRTVVLKVRRFDFSTLTRSETLGGPTDDEAVITSTARRLAEQVDITGGVRLLGVGVAQLADYTQEDLFAQALREEAAEHAEAAEAAVAEEEPEEPVVRRWMPGQDVHHAEWGPGWVQGSGVGRVTVRFETPWSGPGRVRTFAVDDPALEPAPPLPLRQAEEPGSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU0</accession>
    <name>A0A1E7NDU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0019655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287238.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6510"/>
    <dbReference type="EnsemblBacteria" id="ARF81283">
        <property type="protein sequence ID" value="ARF81283"/>
        <property type="gene ID" value="B6264_22390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38876">
        <property type="protein sequence ID" value="OEV38876"/>
        <property type="gene ID" value="HS99_0019655"/>
    </dbReference>
    <dbReference type="OMA" id="EFAPMGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="40687" checksum="EA5C3B2BB16D5706" modified="2017-01-18" version="1">MPLALLALAIGAFGIGTTEFVIMGLLPQIAGDYGVSVPTAGLLVTGYALGVVIGAPLMTVLGTRISRKTMLMLLMALFTVGNLLSAVAPSFPLMLAGRIVTSLAHGAFFGIGSVVAAELVAPQKKAGAIATMFTGLTVANIVGVPLGTFIGQAVGWRTTFTAVAALGLVGLLGIARLVPAVPRPEGAHLRRELTAFRNPQVLLAMAMTVLGFGGVFAAITYIAPMMTHVTGYSDGAVTWLLVLFGVGMFLGNLLGGRFADRHLMPMLYGTLGGLALVLALFTLTAHNEITAAATILLVGALGFATVPPLQKRVLDQAHGAPTLASAVNIGAFNLGNALAAWLGGIVISAGLGYTAPNWVGALLAAAALVLALWSAALERRERTPAPDPAAAPRIPAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE74</accession>
    <name>A0A1E7NE74_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83168">
        <property type="protein sequence ID" value="ARF83168"/>
        <property type="gene ID" value="B6264_29930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38945">
        <property type="protein sequence ID" value="OEV38945"/>
        <property type="gene ID" value="HS99_0017675"/>
    </dbReference>
    <dbReference type="OMA" id="SIFCATS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="12468" checksum="418745658EEBD094" modified="2017-01-18" version="1">MTAVAAAAAVGLAAEPALAATNPTWIGLSTSHGVGVYSNYYASSSKIAPDLFPANGASVEADCWVAGGYVGNDGDVWYHVTWIYLGTPSQTGFPQPANGWVFGPYVDGAAAFHNGTLPNCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG4</accession>
    <name>A0A1E7NEG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557163.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4092"/>
    <dbReference type="EnsemblBacteria" id="ARF83330">
        <property type="protein sequence ID" value="ARF83330"/>
        <property type="gene ID" value="B6264_30900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39101">
        <property type="protein sequence ID" value="OEV39101"/>
        <property type="gene ID" value="HS99_0018625"/>
    </dbReference>
    <dbReference type="OMA" id="EWVEGHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10696" checksum="E5361A7806089068" modified="2017-01-18" version="1">MALRFRGIDPDTPNGGSPTVWLEDEKAEIVIQGWLPEMEMYRVISETEWVEGHAIGVPDHEGVVRIPVRMIPFLRKVCDEAERAGLWRPVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI1</accession>
    <name>A0A1E7NEI1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557508.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1017"/>
    <dbReference type="EnsemblBacteria" id="ARF83276">
        <property type="protein sequence ID" value="ARF83276"/>
        <property type="gene ID" value="B6264_30540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39045">
        <property type="protein sequence ID" value="OEV39045"/>
        <property type="gene ID" value="HS99_0018275"/>
    </dbReference>
    <dbReference type="OMA" id="YQDNTPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="29742" checksum="55F63FE3DDD992AF" modified="2017-01-18" version="1">MSIVVTGASGQLGRLTVEALLRRGVPAADIVATGRDTARIEDLGHRGVVVRRADFAEPDSLAAAFQGADRLLLVSTTTVDERSANHRRAVDAAVAAGVSLVAYTSMTQADTATSILARTHRATEEYLREREVPSTLLRNSWYLENYTAQLPLFRRRGTVIGAAGKGRISAASRADYAEAAAAVLTTEGHAGAVYELGADEAFTLAELAEAVSAATGEPIAYTDLPADRLSEALTGVGLPAELAHVLADADLGMSRGELYTGSGDLSRLIGRPATALSDAIAAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV2</accession>
    <name>A0A1E7NEV2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0000265</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070043269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000410.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3516"/>
    <dbReference type="EnsemblBacteria" id="OEV39202">
        <property type="protein sequence ID" value="OEV39202"/>
        <property type="gene ID" value="HS99_0000265"/>
    </dbReference>
    <dbReference type="OMA" id="ELRFRWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199067" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="33"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="314"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV39202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="507" mass="54923" checksum="D605511C6229CC6F" modified="2017-01-18" version="1">MVIALFGPRVGLALALVLSAALLSASVPSATAAGRLGDPVFPALGNTGYRALDHDLSFEYRPGSRTVDATAVITTLLSRTLAHLELDSLGLDVHAVRVDGRPARFATHGEKLTVTPARPLRRGATARLTVEYTADPRAALPHTGWVPTPDGFAVAGQPASAHTVFPCNDHPSDKARFTVAVTAPDALLGVANGELTQTERLGDGRTTRHYVSREPMATELVQVSVGDYTVRERTGPRGLPLRDVVPTARLAELTPALDLTADQLHWAEQHLGPFPFESYGILPANTDDPAAFGFTGLETQTLTLYKPGFLRQAEPAIGSHMMHELVHSWFGDSVSPATWADLWLNEGHADYYGLLYRYERGWPDAWGHTTLVDRMRMLYGLGDQWRHDAGPVASPTADNLFDSQRYTGGALVLFALREKVGAATFDRIERTFLREHRYGNATTRDYVRTASEVSGQDLRGFLDDWLYGRRTPPMPGHPDWTVAPVGAVPAAGERAAGPGAQEASGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ2</accession>
    <name>A0A1E7NEZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284994.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000137.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3605"/>
    <dbReference type="EnsemblBacteria" id="OEV39271">
        <property type="protein sequence ID" value="OEV39271"/>
        <property type="gene ID" value="HS99_0000700"/>
    </dbReference>
    <dbReference type="OMA" id="FCCNFSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="236"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="45151" checksum="039D0DBCB397DD3C" modified="2017-01-18" version="1">MTGTTQVSAPPNTEPARQSLWHNHDFLRFWVGETVSLLGTQVTNLALPLTAIGAFGATDEQVGLLRFLQLVPYLGLALVIGVWADRHRRRPVMLGANLVRLILLAMVPLLYWWHALDLPVLMVIACTVGIASVVFDVSWMSYVPVLVKSPEHYVEASARMGTSSSAADVAGPGLGGVLVSAVGAPVAVLVDACSYAVSLLSLLSIRTTEPAPAPAAERRLWRELKDGMGWVMRDRVLRSLALIGFCCNFSMITVWTMFLLYGHHDLRLGDGTIGAVFSTASVGGLIGALIARRVIARFPLGRVYLVGQSALLLGPGLIPAAAGPRPVMIGMFVLSFFTTYLGLGVAGVIIVSLRQAVTPQSMMGRMTAAFRTLLFGGGSLGGLAAGLLTGRLGGRGALVVAAVGSAAVVVGLLVSPVSRLRALPAAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF19</accession>
    <name>A0A1E7NF19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550256.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3641"/>
    <dbReference type="EnsemblBacteria" id="OEV39299">
        <property type="protein sequence ID" value="OEV39299"/>
        <property type="gene ID" value="HS99_0000875"/>
    </dbReference>
    <dbReference type="OMA" id="NYWTSID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25696" checksum="C13954E72DDB2E18" modified="2017-01-18" version="1">MDTTHEEDRGTPVGRRVVLGLLGLGAAGVAAGPFLQRLESGLAERDPSGLTGLLPGNNGFRYYSVVTSVPERDATNYTLTVDGLVERPATHRLADLQAMPQRRLVKDVQCVTGWRVPDTPFEGVPLAHLLDTAGVQPGAKAVRFSCFDGAYTESLTLDQARRDDVLVALSLQDKPITHDHGGPVRLYVAPMYFYKSAKWLSGITVTDEVQPGYWEGNGYDVDAWVGRSNGRVDAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH8</accession>
    <name>A0A1E7NFH8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5114"/>
    <dbReference type="EnsemblBacteria" id="OEV39459">
        <property type="protein sequence ID" value="OEV39459"/>
        <property type="gene ID" value="HS99_0001805"/>
    </dbReference>
    <dbReference type="OMA" id="LPYQPVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13225" checksum="73D698E190F18109" modified="2017-01-18" version="1">MVTFAGVLVFILALFNGLNGIAAISRSHVFVAGAHIVVGDLRAWGWTLLILGILLALIAAGILAGSQLARWVGVAVLSLNAFSHMWVVASYPLWSVLIIVLDILAIYALCVHWGTHEHEEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ8</accession>
    <name>A0A1E7NFJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285987.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7529"/>
    <dbReference type="EnsemblBacteria" id="OEV39418">
        <property type="protein sequence ID" value="OEV39418"/>
        <property type="gene ID" value="HS99_0001585"/>
    </dbReference>
    <dbReference type="OMA" id="WIRVPGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26994" checksum="4819AB9D27CC6FFC" modified="2017-01-18" version="1">MNPKYEYRALLACDIAGSAGRGQQRLQEIRSALRSALSGALDLAELDRRDVSYVDTGDGCRLVAPAGLPKAGLLVPLLPELSARIREHNRQAGPDTRLRVRAAVHAGEVRFDPDGTVSGTPFEALARLLDSTPLRRAAVAGPDGAPLAAILSQHYYEETVGHGYEGLETGAFTAAEVVVKEYSARAWLWYPGSPVGPYGGSGREPGSGGRPAEAGKRPTEAGPRTVEQLVRATGNGTVFAVGRGDQHIRYNERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN3</accession>
    <name>A0A1E7NFN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0001970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481238.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5081"/>
    <dbReference type="EnsemblBacteria" id="OEV39484">
        <property type="protein sequence ID" value="OEV39484"/>
        <property type="gene ID" value="HS99_0001970"/>
    </dbReference>
    <dbReference type="OMA" id="MGTPRLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199093" evidence="10">
        <location>
            <begin position="28"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="62"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="293"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="329"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="619" mass="63893" checksum="F7B3CAF8BE04F5AC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS7</accession>
    <name>A0A1E7NFS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285795.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6737"/>
    <dbReference type="EnsemblBacteria" id="OEV39556">
        <property type="protein sequence ID" value="OEV39556"/>
        <property type="gene ID" value="HS99_0002415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="25282" checksum="D697E0654E745E30" modified="2017-01-18" version="1">MKHSILDGTPADTFPVVEPARPPVRTRVRDCMSRAAVAVTPRTDFATMSAVLIASRRGITPVVGADGTVAGVVAASDLLVAHAAEDPDRELLARDLMTSPAVTVTEDMSVTEAVALVAGHSLHHLPVVDADGRLTGLLSTHDLLDALRREDEAVRSEAFALALTPGSGVVPASLHIRCERGLLSITGRTRTRGDAATLCLQLARIDGLRALADHLSWDLDDIDPGPPVTDDADTTGSGGGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY0</accession>
    <name>A0A1E7NFY0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39403">
        <property type="protein sequence ID" value="OEV39403"/>
        <property type="gene ID" value="HS99_0001490"/>
    </dbReference>
    <dbReference type="OMA" id="TEIAYAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30344" checksum="B801D56C16C5DF6D" modified="2017-01-18" version="1">MHQLDQAAREGGDGCIDILSPPPGTDPEDCLHVALHVHGAASVRRGGASTVLAPGDLLISATPHPAGLLQDSECRMLLFRVPCFYLGVRQSDVRRAGGLVARGNEGTGSLASQFLRTLAAQARAHRARPGNHLARSVSDIVAVLVAELLDREDPEHPTGAAELLSRIRAHIEENLADPDLSPESIARSQHISVRYLHKLFQQDGTTVGQWVRRRRLDACRRELERPSRRQASVSAVAHRWGFVSHSHFSRAFREAFGVSPREWQAYATRTEGHNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG05</accession>
    <name>A0A1E7NG05_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0002795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550324.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2753"/>
    <dbReference type="EnsemblBacteria" id="OEV39617">
        <property type="protein sequence ID" value="OEV39617"/>
        <property type="gene ID" value="HS99_0002795"/>
    </dbReference>
    <dbReference type="OMA" id="LTYCGYD"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="386" mass="41404" checksum="69F1AA2F596115A0" modified="2017-01-18" version="1">MSNTPSTTEIEVPRGLKGVVVTETELSDVRGLEGFYHYRQYSAIDLAEQRTLEDVWHLMLLGELPDPARRAAFLARTAPLRRLPDALRPLLPALAASTAHGGPLTALGAALSIAAADRGIRPLYDTAPEQRVEDALFATALVPTVLTALHRLQNAQQPIEPREDLGYAANYLYMLTGEEPEPAKARAIEQYLISTVDHGFNASTFTARVIASTGADLVACLVGGLGALSGPLHGGAPSRALDTLDAIGTPERIDGWIRERVLAGDRIMGFGHAVYRTEDPRSRMLRGVAQSFGGELVDLAVQVEAQVEAILAELKPGRELHANVEFYAGVVMHLCGLPREMFTPTFAAGRAIGWSANILEQAADSKIIRPSARYTGPAAPAPLPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG80</accession>
    <name>A0A1E7NG80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550422.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2837"/>
    <dbReference type="EnsemblBacteria" id="OEV39687">
        <property type="protein sequence ID" value="OEV39687"/>
        <property type="gene ID" value="HS99_0003215"/>
    </dbReference>
    <dbReference type="OMA" id="PLWQFDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="47207" checksum="E4DA34A5C003D38F" modified="2017-01-18" version="1">MSTVTAGKAAAGPAAGPATRRVPVGRVYRFELVKLVSQWRIRLLVLACWALPGLFVAAVAQQGTLPSDTLFGRWMHATGWAGPLVVLGFAGSWALPLLTSVVAGDVFAAEDRLGTWRHLLVAVRSPRRIFLAKTLAGATVLALLVAGLVASSTVGGLAAVGNRPLVGVDGHQLAPSDAAASVLLAWACALAPTLALAALGLLGSVALGRSPMGLLVPALSAVAMQLAQMLPLPVALRLALPGYAFVSWNGLFADPARLTELLIAVAVSLVWAVVATTAARVLFLRRDFTNGSEDGGGRRALAFGAAPLAGLLALTFGAVAVATPSTGSGITQAKVQRTVTTVFAHLYRLQTEQLHRPTVTEADLRVTADCGRGDGQVDPEGPGNDWRCTVTWHLPGTAAPGTAIYQLDVASDGRVMADGDGPKEVNGYFLVHTGAGDAPNPLWQFDGQVDLLASPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH90</accession>
    <name>A0A1E7NH90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556304.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000671.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5112"/>
    <dbReference type="EnsemblBacteria" id="OEV39823">
        <property type="protein sequence ID" value="OEV39823"/>
        <property type="gene ID" value="HS99_0001820"/>
    </dbReference>
    <dbReference type="OMA" id="HGDYRHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="138"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="27609" checksum="5D5633E1010B48BE" modified="2017-01-18" version="1">MRGEAFANVSYTLFAAQAQREGRPAVADLFRKAAAVELGEHFTQEAAPSGLVGGNEANLTDAISGEGYESTTMYPTFARQARAAGDTAAADLFTEIAKDEAAHQAAYKAALTALRSGKGAIPAPPAITPVTVTAGQPKVTSAQTRANLDTAMHGEALAHAKYTLYAQRAQQSGNAALARLFTAVSDVELQEHFSGEAALAGSVGTTSHNLATAIAGETYESKTMYPTFAQQAKTAGDTAAATLFQHNATDEADHAQAFQTARKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SPE6</accession>
    <name>A0A176SPE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024625</name>
        <name evidence="2" type="ORF">HS99_0024885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389956.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82590">
        <property type="protein sequence ID" value="ARF82590"/>
        <property type="gene ID" value="B6264_03100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82596">
        <property type="protein sequence ID" value="ARF82596"/>
        <property type="gene ID" value="B6264_03375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37862">
        <property type="protein sequence ID" value="OEV37862"/>
        <property type="gene ID" value="HS99_0024625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37867">
        <property type="protein sequence ID" value="OEV37867"/>
        <property type="gene ID" value="HS99_0024885"/>
    </dbReference>
    <dbReference type="OMA" id="VANSKMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23152" checksum="92C0FB2A65C4937A" modified="2016-09-07" version="1">MSDDELERSPVVANRAMNRERALTGVNSYARELGLDPAQWLLDRPELGSWLDLCSGEGLALTAAAGRLPAATVLTGVDLVGPIGLRRVAPNVRLIVASLADWAPRQPYDLITCVHGLHYIGDKLGLLGRAAGWLSPDGLFLAQLDPASLRRVDGRSLARPGLAALRAAGFEYQPRRHLLTLRGRRSVRLPFDYLGADTTAGPTYTGQPAVASYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV05</accession>
    <name>A0A1E7MV05_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550542.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2964"/>
    <dbReference type="EnsemblBacteria" id="OEV32261">
        <property type="protein sequence ID" value="OEV32261"/>
        <property type="gene ID" value="HS99_0016210"/>
    </dbReference>
    <dbReference type="OMA" id="PAQSHGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="39060" checksum="9922E6DFC6DF245F" modified="2017-01-18" version="1">MSTEPTASATVPADGPSVRIGALVPLTRPGWIEAGRHVLAGLEAAVRDVNDAGGIAGRQLELLVRDTAADPQRAAEAVEELDRLGVAAVAGEYHSVVARAVAARADALGLPFLCSSAVLDALTDEPSELVARLCPAQSHSWRIYADFLLGAGHRRIAVATRPSVYWAAGVRVLRDHLAPHGGTVVELDTGALSPAALCEELVRHDATALLLLVGHPEPAVPIVRAVRHDGRLTEVLIGAPAGQPEFAEWSVLLGADGAGVPFLRYLPERLGPLGARVGAALRERLGEAPSFVAFEGYDTVTVLAEVLRTAGTGRKTIAEAWPRVGVEGTRGPIRFSRSPGIIVWQWAWPPVQVVDRDPAAPGRFRVLHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV90</accession>
    <name>A0A1E7MV90_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0016770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289622.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6942"/>
    <dbReference type="EnsemblBacteria" id="OEV32352">
        <property type="protein sequence ID" value="OEV32352"/>
        <property type="gene ID" value="HS99_0016770"/>
    </dbReference>
    <dbReference type="OMA" id="ALFWFVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14518" checksum="2313A68BB3DCCAE2" modified="2017-01-18" version="1">MKAEGWLFTVMTVFFAVTGLVYGFWAREPAGKAILTVAFLMSALVALFWFVQHQRKGGGRPEDRKDAEIVESSGSKGFFPPRSGYPVLTALGVALFSLGLVYALWLIVCGAVLLGFAVFGFIFQYHDRGDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW80</accession>
    <name>A0A1E7MW80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288296.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3180"/>
    <dbReference type="EnsemblBacteria" id="ARF78274">
        <property type="protein sequence ID" value="ARF78274"/>
        <property type="gene ID" value="B6264_04505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32688">
        <property type="protein sequence ID" value="OEV32688"/>
        <property type="gene ID" value="HS99_0015580"/>
    </dbReference>
    <dbReference type="OMA" id="GDTDLSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="38551" checksum="9F5FD8A829EA8985" modified="2017-01-18" version="1">MKIDLTNTTSSKINAALMAARRASGSTAAGMVLTLVIVTDEGSAYDALKAANDASREHPMRTLAVIKRAGRSPRARAETRLDAEILVGSDAGSGETVVLRMHGELAAHAQSVVLPLLLPDAPTVVWWPENAPLHPAQDPLGALAQRRITDAVTAESPVGQLAQRAQSYSPGDTDLAWTRLTGWRSMLAAALDQRPSHITAAVVEGESYNPSVELLGLWLLNRLHVPVERIVTGGPGITAVRLRTKDGDITLDRPDGLMGMLSMPGSPDRQVALKRRETSELIAEELRRLDPDDIYSTAVRTPVERLREHDDTVPAAAEQIAQAVEASVAETDGGPTGPVGAVEAGKKPAAKKAAGKRAATRDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW88</accession>
    <name>A0A1E7MW88_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ORF">HS99_0015555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288287.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3175"/>
    <dbReference type="EnsemblBacteria" id="ARF78278">
        <property type="protein sequence ID" value="ARF78278"/>
        <property type="gene ID" value="B6264_04530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32684">
        <property type="protein sequence ID" value="OEV32684"/>
        <property type="gene ID" value="HS99_0015555"/>
    </dbReference>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV32684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="41891" checksum="8808AEEF16D330F9" modified="2017-01-18" version="1">MKTIEDLDVAGKRVFVRADLNVPLSDGRITDDGRIRAVAPTIAKLVERGAKVVVASHLGRPKGAPDPQFSLAPVAERLGEILGRPVAFATDTVGESARSAVAALADGEVVLLENLRFNAGETSKDDAERKAFAEQLAALADLYVGDGFGAVHRKHASVYDLPALLPHAAGDLIATEVGVLKKLTEDVKRPYVVVLGGAKVSDKLGVIDNLLKKADRILIGGGMAYTFLKAKGHEVGISLLQEDQIPTVLGYLAEAEERGVEFVLPVDVLVSAEFPDLKGKTPANPDTVASDEIPADKEGLDIGPKTRELYAAKLADAGTVFWNGPMGVFEHPDYANGTKAVAQALIDSNAFTVVGGGDSAAAVRILGFDETKFGHISTGGGASLEYLEGKTLPGLAALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC7</accession>
    <name>A0A1E7MWC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557647.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7838"/>
    <dbReference type="EnsemblBacteria" id="ARF78229">
        <property type="protein sequence ID" value="ARF78229"/>
        <property type="gene ID" value="B6264_04235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32731">
        <property type="protein sequence ID" value="OEV32731"/>
        <property type="gene ID" value="HS99_0015850"/>
    </dbReference>
    <dbReference type="OMA" id="RMCRIVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="23917" checksum="AEE5772259AF2F9A" modified="2017-01-18" version="1">MTVDTGAPSFWLSLPDGFTAVDLAEDPGDRMCRIVDGLDALTDVSPEQKLSIAVAAESALQAQLREGAVHVSNCLVPTDGGTIAQGVLSLFLRQEALEPRGTYPQRAAEQLTAAWPDAEIAVLDFTPGRAAVVARDLTVPVSGAVYGLPGSGAVTVRQLEVLIPHPWSPHVLAAVFTTRNLDHWEGWLPVVGAAIDGISFYPPRSDSRDDLPPDQWDTIRKAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG3</accession>
    <name>A0A1E7MWG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385820.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6099"/>
    <dbReference type="EnsemblBacteria" id="ARF78185">
        <property type="protein sequence ID" value="ARF78185"/>
        <property type="gene ID" value="B6264_03980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32770">
        <property type="protein sequence ID" value="OEV32770"/>
        <property type="gene ID" value="HS99_0016100"/>
    </dbReference>
    <dbReference type="OMA" id="EAMYAES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="597" mass="63266" checksum="EABCCFE78FAA8A12" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ2</accession>
    <name>A0A1E7MWJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0015670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7872"/>
    <dbReference type="EnsemblBacteria" id="OEV32798">
        <property type="protein sequence ID" value="OEV32798"/>
        <property type="gene ID" value="HS99_0015670"/>
    </dbReference>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27433" checksum="CBBA38F9A0864051" modified="2017-01-18" version="1">MPVTAAEVLLEGHRATRDRVARSILDHGPSSAADLANRLGLTAAAVRRHLDGLAAAGLVESREQRVYGSRGRGRPAKVFALTDGGRDAFYQAYDQLAADALRWISDSVGGGKAGEEAVAAFARARFGKQGEKYRETLRRAEAGERPEALAEALSADGYAATVRRVPSAVAKAPAGAQLCQHHCPVAHIAEQFPQLCEAETEVFSQLLGTHVQRLATIAHGDGVCTTYVPAPGAASSPSQRSAGHGSDAVPTAGTSTEDSASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ4</accession>
    <name>A0A1E7MWQ4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein HS99_0039740</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene80"/>
    <dbReference type="EnsemblBacteria" id="ARF80124">
        <property type="protein sequence ID" value="ARF80124"/>
        <property type="gene ID" value="B6264_15425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32861">
        <property type="protein sequence ID" value="OEV32861"/>
        <property type="gene ID" value="HS99_0039740"/>
    </dbReference>
    <dbReference type="OMA" id="PACHAPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6473" checksum="EBAA21BC22810D9A" modified="2017-01-18" version="1">MKLESFLLEILVCPQCRAALTEGGTEEQPELVCTGADCGLAYPVREGIPVLLVDEARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR5</accession>
    <name>A0A1E7MWR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554361.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene446"/>
    <dbReference type="EnsemblBacteria" id="ARF78863">
        <property type="protein sequence ID" value="ARF78863"/>
        <property type="gene ID" value="B6264_07985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32886">
        <property type="protein sequence ID" value="OEV32886"/>
        <property type="gene ID" value="HS99_0039625"/>
    </dbReference>
    <dbReference type="OMA" id="RSGWCAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="541" mass="58036" checksum="37AAF030710E4D77" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY9</accession>
    <name>A0A1E7MWY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0013770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552542.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5767"/>
    <dbReference type="EnsemblBacteria" id="ARF81358">
        <property type="protein sequence ID" value="ARF81358"/>
        <property type="gene ID" value="B6264_22795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32948">
        <property type="protein sequence ID" value="OEV32948"/>
        <property type="gene ID" value="HS99_0013770"/>
    </dbReference>
    <dbReference type="OMA" id="GMRTWPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="751" mass="75245" checksum="5451380F9F0C4190" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX11</accession>
    <name>A0A1E7MX11_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5766"/>
    <dbReference type="EnsemblBacteria" id="OEV32949">
        <property type="protein sequence ID" value="OEV32949"/>
        <property type="gene ID" value="HS99_0013775"/>
    </dbReference>
    <dbReference type="OMA" id="SHFADME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23385" checksum="4377DCBBB551C871" modified="2017-01-18" version="1">MKRTEAAVPVTDGRTERGRQTREKIADAMLSLIDENQAHFPADKVAERAGVSRRLVFHHFADMAELAEVAVNRRLEQLAAQIRPLPTEGPRELRVAALTEQRARILEGVTPARLAVMRLENPSPRIQEAVQQMLDFARLRLTQIFAAELDALPESARTDLLHGLDAVTTWSAWYHWRSGGLSTEQARRTMAAAVHALLAGAGAGAGAGAGAEAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX15</accession>
    <name>A0A1E7MX15_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase/protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000645.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5708"/>
    <dbReference type="EnsemblBacteria" id="ARF81411">
        <property type="protein sequence ID" value="ARF81411"/>
        <property type="gene ID" value="B6264_23090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32995">
        <property type="protein sequence ID" value="OEV32995"/>
        <property type="gene ID" value="HS99_0014060"/>
    </dbReference>
    <dbReference type="OMA" id="WMWERID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35017" checksum="4FF1815583431AEF" modified="2017-01-18" version="1">MAPRTIDLNSYVTGVLDGSRAWIARAVTLVESTRPDHRVLAQQLLQRLLPHAGGAVRVGITGVPGVGKSTFIDSFGTMLTGLGHRVAVLAVDPTSSRTGGSILGDKTRMERLAVDPAAFVRPSPTSGTLGGVAKATRESMVVMEAAGYDVVLIETVGVGQSETAVAGMVDTFLLLSLARTGDQLQGIKKGVLELADVIAVNKADGPHERDARAAARELAGALRLLQAPDAAWTPPVLTCSGLDGAGLDVLWERLQQHRKVLDATGALAAKRREQQVEWTWSMVHDQLYARLHEHPEVRRLAPSLEAEVRAGTLPAGLAAQQILDSFFGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX62</accession>
    <name>A0A1E7MX62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5697"/>
    <dbReference type="EnsemblBacteria" id="ARF81422">
        <property type="protein sequence ID" value="ARF81422"/>
        <property type="gene ID" value="B6264_23145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33004">
        <property type="protein sequence ID" value="OEV33004"/>
        <property type="gene ID" value="HS99_0014115"/>
    </dbReference>
    <dbReference type="OMA" id="WEREWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="19691" checksum="4552E2CB68B41BFC" modified="2017-01-18" version="1">MARPLDRARARAWLLTVLGGFLATALAVGGALLFYRSTAPQADADRARLHRVDAVVTAATEHGVTTGSRFSGGYGSRVDAEASWTYPGATRHTGIVQAPRAATTGTVVPIWVDPAGNASTPPVDRGALAVSAACTGTGALLTLFAFLAFALRLRLNVLDHRAEAEWTAGWARLEPLWSGRAGNRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX67</accession>
    <name>A0A1E7MX67_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">HS99_0014280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279808.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5664"/>
    <dbReference type="EnsemblBacteria" id="ARF81452">
        <property type="protein sequence ID" value="ARF81452"/>
        <property type="gene ID" value="B6264_23310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33036">
        <property type="protein sequence ID" value="OEV33036"/>
        <property type="gene ID" value="HS99_0014280"/>
    </dbReference>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16137" checksum="1544607287CA5EB8" modified="2017-01-18" version="1">MSGHGAPELTIDGAADLKVAVIAAQWHDQVMNGLLDGAHRALKELGVAEPTVLRVPGTFELPVAAKRLAEHGYDAVVALGVVIRGGTPHFDYVCQAATAGLTQVSVDTGVPVGFGVLTCDNEEQALDRAGLPGSAEDKGHEAVTAAVATAVTLRDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA3</accession>
    <name>A0A1E7MXA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387062.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5620"/>
    <dbReference type="EnsemblBacteria" id="OEV33070">
        <property type="protein sequence ID" value="OEV33070"/>
        <property type="gene ID" value="HS99_0014495"/>
    </dbReference>
    <dbReference type="OMA" id="TFALWST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="232"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="431" mass="44131" checksum="640C9CC1C3B4D826" modified="2017-01-18" version="1">MTATLAPPPEHPQVRSCWGLFAQRDFRLLWAGQTVSRLGSSVTTVALPLVAVLTLGAGPLSTGLLTGAIWLPWLLFGLPAGVWVGRAPRRAVMIGCNLGSAALFASVPVAGWFGGLTMAQLLAVAFLGGVCSVFFDAADQAYLPELVAPEGLIEGNAKLTGGGSAAEVAGRGLAGLIVQFLGAAGGLLVDAVSFLVAAATLLRIRARSAPAPLEQADLLGQVREGLSFLLRDPYLRAFLCFGAAANFALMGYQSILPLFLVRSAGIAPGWVGALASAAAVGGVLGSLAARPLCRRLGTARGTRIVLLTVTPFGLLMPLAGPGAGTVLYVIGSLAVVAAVVLCNIVLGSFRQSYTPPELLTRVSAGAMFAVHATIPLGALTGGALGELIGLRATMWVMTGLLTLTGTLPLFSPLRSLRELPTTPPENGKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS8</accession>
    <name>A0A1E7MXS8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7096"/>
    <dbReference type="EnsemblBacteria" id="OEV33214">
        <property type="protein sequence ID" value="OEV33214"/>
        <property type="gene ID" value="HS99_0039195"/>
    </dbReference>
    <dbReference type="OMA" id="LPFEGDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="2">
        <location>
            <begin position="431"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="859" mass="94229" checksum="840EC890DD785D45" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT0</accession>
    <name>A0A1E7MXT0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366418.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5903"/>
    <dbReference type="EnsemblBacteria" id="ARF82067">
        <property type="protein sequence ID" value="ARF82067"/>
        <property type="gene ID" value="B6264_27145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33229">
        <property type="protein sequence ID" value="OEV33229"/>
        <property type="gene ID" value="HS99_0039100"/>
    </dbReference>
    <dbReference type="OMA" id="FRHQLAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="33311" checksum="258E8B40655A049A" modified="2017-01-18" version="1">MKFFRAKEKPQYDPDLTNLTVDQAEHLRQLVRRYHADIGVQVTVSGQTLRRAEGTNNLYNLAEFCRRTDPSDWPGIVARHFGSLTGAARTVPGGADETLSRVYLRLVADDAFPAEIASAFSYTRPVATGLLEALSVDLPDTVRTLDDKAVAEVGLQRLRAAGRANLIADPVEYDVLQGPTEGSTLYAVHGDSMFVASKALVLDDLARAVTGRELPEEGALFAAPSREYLFFHPLAEAGVAGAVNDLASMALRVHQENPGPLSPRLYWWHKGEVTNLTRIDEAERSFSIEPPDELMAVLRRLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI7</accession>
    <name>A0A1E7MYI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549892.1">
        <property type="nucleotide sequence ID" value="NZ_JNWR01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5151"/>
    <dbReference type="EnsemblBacteria" id="ARF80587">
        <property type="protein sequence ID" value="ARF80587"/>
        <property type="gene ID" value="B6264_18240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33481">
        <property type="protein sequence ID" value="OEV33481"/>
        <property type="gene ID" value="HS99_0013020"/>
    </dbReference>
    <dbReference type="OMA" id="AVMTTYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14257" checksum="CC31D347D90EE523" modified="2017-01-18" version="1">MPVIRSADARRTETPNAVMTTHASPTQGSTALAQWKVEMPADRQGPLHAMDTEQIWTFLTGSAEVDLAGESIAVAAGDTLVLPADAPRRIATAEGFTAVVASPSPSHAYNPDARTPDGACALAPRDAERLLPAWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP6</accession>
    <name>A0A1E7MYP6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5244"/>
    <dbReference type="EnsemblBacteria" id="ARF80663">
        <property type="protein sequence ID" value="ARF80663"/>
        <property type="gene ID" value="B6264_18695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33558">
        <property type="protein sequence ID" value="OEV33558"/>
        <property type="gene ID" value="HS99_0013475"/>
    </dbReference>
    <dbReference type="OMA" id="QANPGEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="17168" checksum="18F612D2AAA34330" modified="2017-01-18" version="1">MATWEDFEQEAPELAALVRARFEAEKHHVLATLRKDGSPRVSGTEVDFVGADVWLGSMYGAVKARDLQRDGRFALHAHPGGEAMTGGDSKLSGRAVEVTDEAELAAFAADLPEPPPSPFHLFRLDIQQVVHTTLEGDALWVLNWHPGRPVEKIQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR5</accession>
    <name>A0A1E7MYR5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="7" type="ORF">HS99_0013515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5252"/>
    <dbReference type="EnsemblBacteria" id="ARF80671">
        <property type="protein sequence ID" value="ARF80671"/>
        <property type="gene ID" value="B6264_18735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33566">
        <property type="protein sequence ID" value="OEV33566"/>
        <property type="gene ID" value="HS99_0013515"/>
    </dbReference>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="35642" checksum="D1A18B4A3C25C7EB" modified="2017-01-18" version="1">MSAVAPDGRKLLRLEVRNSETPIERKPEWIKTRAKMGPEYNALQSLVKKEGLHTVCQEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAEFDRDEPRRVAESIVTMDLNYATITGVARDDLEDGGAWLYAETVRQVHAMTADRAGGRTGVELLIPDFNAVPEQLAEVFSSRPEVLAHNVETVPRIFKRIRPAFRYERSLDVITQARAAGLVTKSNLILGMGETREEISQALADLVGAGCELITITQYLRPSLRHHPVERWVKPQEFVELQEEAEELGFAGVMSGPLVRSSYRAGRLYRQALERREQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX1</accession>
    <name>A0A1E7MYX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290697.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1085"/>
    <dbReference type="EnsemblBacteria" id="ARF78970">
        <property type="protein sequence ID" value="ARF78970"/>
        <property type="gene ID" value="B6264_08615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33650">
        <property type="protein sequence ID" value="OEV33650"/>
        <property type="gene ID" value="HS99_0038610"/>
    </dbReference>
    <dbReference type="OMA" id="WVGTGMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="20365" checksum="C8A8BBA3B2DE1FDB" modified="2017-01-18" version="1">MTAIRPTVALAYHSGYGHTAVIAEAVARGAAAAGAEVVSIAVDTITDEQWAQLDAADAIVFGSPTYMGTASGAFHVFAEATSKRWFTDAWKDKVAAGFTNSASKSGDKASTLGYFQTLAAQHGMNWVNLGLKPGWNATTASENDLNRLGFFNGAAASSPSDAGAEAVHKADIATAEHLGERVARHTAIVLAGRAALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ91</accession>
    <name>A0A1E7MZ91_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">HS99_0038070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030056747.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7693"/>
    <dbReference type="EnsemblBacteria" id="ARF78558">
        <property type="protein sequence ID" value="ARF78558"/>
        <property type="gene ID" value="B6264_06200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33752">
        <property type="protein sequence ID" value="OEV33752"/>
        <property type="gene ID" value="HS99_0038070"/>
    </dbReference>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="57" mass="6474" checksum="093C95BB17830B43" modified="2017-01-18" version="1">MAVPKRKMSRSNTRHRRSNWKAVVPALVACDRCHEPKLGHIACPSCGTYNRRQVLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ5</accession>
    <name>A0A1E7MZJ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557787.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4392"/>
    <dbReference type="EnsemblBacteria" id="ARF80310">
        <property type="protein sequence ID" value="ARF80310"/>
        <property type="gene ID" value="B6264_16600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33849">
        <property type="protein sequence ID" value="OEV33849"/>
        <property type="gene ID" value="HS99_0037570"/>
    </dbReference>
    <dbReference type="OMA" id="QDLIAYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="540" mass="58107" checksum="E268BC1FFAA153BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N084</accession>
    <name>A0A1E7N084_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34085">
        <property type="protein sequence ID" value="OEV34085"/>
        <property type="gene ID" value="HS99_0011645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="17535" checksum="788E00138386E5F6" modified="2017-01-18" version="1">MNRFAQIRPSGTMAAMTGGDDPSSSPRDGVPDRAGERYRPFAHLTTESCELCRRVMGVFVRAEQEFTVHLRPEDVHLGLAPEGRPPLEAVAVAPERLVIHSTERGTTGGQLTWWSNSPALAARRNSANLAGAVRTMTSPSSDSRSSTTPSAVRTSTQLSFAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A0</accession>
    <name>A0A1E7N0A0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000100.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3704"/>
    <dbReference type="EnsemblBacteria" id="ARF77979">
        <property type="protein sequence ID" value="ARF77979"/>
        <property type="gene ID" value="B6264_02690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34118">
        <property type="protein sequence ID" value="OEV34118"/>
        <property type="gene ID" value="HS99_0011835"/>
    </dbReference>
    <dbReference type="OMA" id="DMSHRRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="652" mass="70618" checksum="13973466A982ECEC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E5</accession>
    <name>A0A1E7N0E5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2197"/>
    <dbReference type="EnsemblBacteria" id="OEV34159">
        <property type="protein sequence ID" value="OEV34159"/>
        <property type="gene ID" value="HS99_0010960"/>
    </dbReference>
    <dbReference type="OMA" id="ARESEPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="18983" checksum="D3016103CC5EDF55" modified="2017-01-18" version="1">MIGQIAASIRRERERSGVSMTELARRAGIAKSTLSQLESGAGNPSVETLWALGVALNVPFSRLVDPPRPTVKVLRAGEGPVTHSEQANYAATVLSSCPPNARRDIYRIEAQPGETRASDPHMPGTVEHVMIGSGRALVGPTEAPVELGPGDYISYPGDAPHVFRALAADTLAVIVMEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R4</accession>
    <name>A0A1E7N0R4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0036760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283684.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2586"/>
    <dbReference type="EnsemblBacteria" id="OEV34279">
        <property type="protein sequence ID" value="OEV34279"/>
        <property type="gene ID" value="HS99_0036760"/>
    </dbReference>
    <dbReference type="OMA" id="VIGHVHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_N" evidence="12">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="11">
        <location>
            <begin position="154"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="53436" checksum="163F06EF79F057EF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N119</accession>
    <name>A0A1E7N119_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0036165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553525.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3911"/>
    <dbReference type="EnsemblBacteria" id="OEV34361">
        <property type="protein sequence ID" value="OEV34361"/>
        <property type="gene ID" value="HS99_0036165"/>
    </dbReference>
    <dbReference type="OMA" id="GHIAAHS"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="537"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1397" mass="146757" checksum="58193F9F34350CBB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1E3</accession>
    <name>A0A1E7N1E3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7070"/>
    <dbReference type="EnsemblBacteria" id="OEV34496">
        <property type="protein sequence ID" value="OEV34496"/>
        <property type="gene ID" value="HS99_0035450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="20859" checksum="7B13C6F3A89DC9BD" modified="2017-01-18" version="1">MREMAESAVLHAVVPLLTVQRLRERLAPVADDPRFTVVVRDGWDGPQAWVGCPAGPGAAGEVERVLRVPGGGAAGAVPVAGEVPTAGARAVTLTGPFPAAAGLAVEDAAVLALAGWQELLRRRPEQDRSRYSFALHAEPVLPDGWLLQSWVNPAFGPVQFTVRSGSRLAVSSPGRVGREELTVLLAEWTLLVARAGAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1R7</accession>
    <name>A0A1E7N1R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554694.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81984">
        <property type="protein sequence ID" value="ARF81984"/>
        <property type="gene ID" value="B6264_26645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34650">
        <property type="protein sequence ID" value="OEV34650"/>
        <property type="gene ID" value="HS99_0009135"/>
    </dbReference>
    <dbReference type="OMA" id="CATAIEK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19079" checksum="A0611D1CD93A9FF3" modified="2017-01-18" version="1">MTQSTPAAGKDPAGTGPEASVPVPAAASGGPISHAIFRLARLHRMFAGQLLRRIGLHPGQELVMMHLWELGPQRQTDLVRLLDSDAATMTRTIQRLEQAGFVRRRPSPTDKRASLIEPTAASHALRREVEQSWSQLEDLVTAGLSADECTEALSTLERLEQNLVQAAADPTCAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z1</accession>
    <name>A0A1E7N1Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34720">
        <property type="protein sequence ID" value="OEV34720"/>
        <property type="gene ID" value="HS99_0009540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="6937" checksum="D355F1102713073C" modified="2017-01-18" version="1">MAAAALSKTATGPSPWPCKKSPAQNRGRCARAALTAGPVGANSFGYTSVIGLPDLGPAAAAEYGWTCIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N204</accession>
    <name>A0A1E7N204_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34712">
        <property type="protein sequence ID" value="OEV34712"/>
        <property type="gene ID" value="HS99_0009490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24891" checksum="7FBE3956CCFE903E" modified="2017-01-18" version="1">MEFKIEVVVVPVSDVDRAKDLYTRIGFREDVDFSGPGGFRIVHLTPPGSVASLIIGSGVTDAAPGSERGVHLIVDDVVAARAEWADAGVEVSEVFHDAGGVFHHAGTAERVAGPHPGRQSYSSFTSFAGPDGNTFVLQEVTARRSTGSLRPSSRSSPAGWTPSPWPWSSPCPPRRRSARRPAPDSLPACRNYRWTGSATTIPGPCSTRCCPVRCTPVCETRSSPKHAATRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N247</accession>
    <name>A0A1E7N247_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555812.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4587"/>
    <dbReference type="EnsemblBacteria" id="ARF81869">
        <property type="protein sequence ID" value="ARF81869"/>
        <property type="gene ID" value="B6264_25930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34768">
        <property type="protein sequence ID" value="OEV34768"/>
        <property type="gene ID" value="HS99_0009825"/>
    </dbReference>
    <dbReference type="OMA" id="WPLMVVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30567" checksum="72D31A535D3EA976" modified="2017-01-18" version="1">MNRTIRRIADHTVLGLLALVFALPVLYLVIGSLKPSDQVLAGLSGFLPTNLSLHNYAAVLHSLSSDSTGHFWRFMGVSLLVAATVVAGGLVVNSMAAYALSRLEWGGRKLLFTLVLLLMLIPFESVAVPLFYLFDTQRNTVWIQAAPFIANAFSVYQFHTFFQAIPVSIEEAARIDGAGPWRILFRIIYPMSKPAFASVAILTFLTQWGSFLWPVLMVDDPSVRPLPLEISVFQGQQPPDWGQILAFGVLLVLPVVVVFAFFQRWFVQGVAGSAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J8</accession>
    <name>A0A1E7N2J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34906">
        <property type="protein sequence ID" value="OEV34906"/>
        <property type="gene ID" value="HS99_0034905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="62" mass="6775" checksum="E1A04704455A4D4B" modified="2017-01-18" version="1">MSSELIRVPDGVSPDISRTIAPSRSFDLGEAVFRAIDQGASKVHHWPLAPVRPYVATDLASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U4</accession>
    <name>A0A1E7N2U4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552845.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4681"/>
    <dbReference type="EnsemblBacteria" id="OEV35007">
        <property type="protein sequence ID" value="OEV35007"/>
        <property type="gene ID" value="HS99_0034280"/>
    </dbReference>
    <dbReference type="OMA" id="TKKWRNL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14655" checksum="B7AE571393366EE4" modified="2017-01-18" version="1">MIFTDKERRYLAAQLLARLATTGPDGAPQVRPVGFRLNDDGTIDIGGPAMARSQKYRNAQARPGVCVLVDDMAPADDPIAPGWGRGVEIRGRAEVLSVDVPPVAPGRFSNDIIRVHPRRVITWNLEALGSASRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N329</accession>
    <name>A0A1E7N329_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0034050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286668.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene415"/>
    <dbReference type="EnsemblBacteria" id="ARF78889">
        <property type="protein sequence ID" value="ARF78889"/>
        <property type="gene ID" value="B6264_08145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35087">
        <property type="protein sequence ID" value="OEV35087"/>
        <property type="gene ID" value="HS99_0034050"/>
    </dbReference>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="60309" checksum="7152F1634BAE0871" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N350</accession>
    <name>A0A1E7N350_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286620.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene386"/>
    <dbReference type="EnsemblBacteria" id="ARF78913">
        <property type="protein sequence ID" value="ARF78913"/>
        <property type="gene ID" value="B6264_08280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35110">
        <property type="protein sequence ID" value="OEV35110"/>
        <property type="gene ID" value="HS99_0034190"/>
    </dbReference>
    <dbReference type="OMA" id="IQWSSGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24684" checksum="CC1DB6AF40992455" modified="2017-01-18" version="1">MPVPRIRLRRAVALLALGVLGPALTAAATTPAVAATAAPTTAHDRAGQHQVRPAAAPGSTADLAGTYKKLNITMQQQQQTNWCWAASGNTIATWFGYSYSQNQFCNAAFGRSIDSSCPNSQASLADVQNGLDWIGINPGSYVTGYLRYSTVQSEVDANRPVETRIQWSSGGGHMHVLYGYDTGNNWVYWGDPWPSNYRYNWADYWYYVNNDTFSWTHSLYRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E7</accession>
    <name>A0A1E7N3E7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">HS99_0033415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555289.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1364"/>
    <dbReference type="EnsemblBacteria" id="ARF79282">
        <property type="protein sequence ID" value="ARF79282"/>
        <property type="gene ID" value="B6264_10450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35221">
        <property type="protein sequence ID" value="OEV35221"/>
        <property type="gene ID" value="HS99_0033415"/>
    </dbReference>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="12599" checksum="AD4E55A959371AED" modified="2017-01-18" version="1">MNWLLVVAGAVAGAPLRYLTDRAVQSRHDSVFPWGTFTVNVFGCLVLGLLAGAVTAGAASSHVQLLVGTGFCGALTTYSTFSYETLRLAESGAGRYALANVAGSLAAGLTAVYAGAELASAIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P4</accession>
    <name>A0A1E7N3P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain fatty acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549999.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5306"/>
    <dbReference type="EnsemblBacteria" id="ARF80718">
        <property type="protein sequence ID" value="ARF80718"/>
        <property type="gene ID" value="B6264_19005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35292">
        <property type="protein sequence ID" value="OEV35292"/>
        <property type="gene ID" value="HS99_0033065"/>
    </dbReference>
    <dbReference type="OMA" id="IAKCPIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="597" mass="63789" checksum="2DD2473BE20004D7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4B8</accession>
    <name>A0A1E7N4B8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2150"/>
    <dbReference type="EnsemblBacteria" id="ARF79428">
        <property type="protein sequence ID" value="ARF79428"/>
        <property type="gene ID" value="B6264_11295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35539">
        <property type="protein sequence ID" value="OEV35539"/>
        <property type="gene ID" value="HS99_0032105"/>
    </dbReference>
    <dbReference type="OMA" id="FSRLHHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="43073" checksum="42E27177C9DF2419" modified="2017-01-18" version="1">MSAQSPVRWTDPEQQELEERVAAAELAWLSMDVDVQTLRVEIDNFALIHHQLLGPLYARLDELDALVAEAVAARTGDPGDLRRAAEARQRVEELPDLDALFDSVREKSGEGVDEAAPPPAAPARVRPGKEAQRIYRELVRRAHPDLTTDGAEKQRRADFLVRVNEAYAYGDTAVLESLAAEWSTAPEAAPAVDSPDRLGWLRRRLDWLTAKITETATEQVRLEQTPMGQLLALAPQDPDRLLEQLAEELLAKAAAQQAELERLLGGPDRPVGHNGTDPNRPQESPTMFAQIPTTDAASVPADAALLDVREQDEWDAGHVDGALHIPIGEVIARIGELPDEKLYVLCRVGGRSAQVVQYLVQQGRDAVNVDGGMYAWEGAGRPMVSSSGQPAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H2</accession>
    <name>A0A1E7N4H2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280424.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5384"/>
    <dbReference type="EnsemblBacteria" id="ARF80783">
        <property type="protein sequence ID" value="ARF80783"/>
        <property type="gene ID" value="B6264_19395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35591">
        <property type="protein sequence ID" value="OEV35591"/>
        <property type="gene ID" value="HS99_0006630"/>
    </dbReference>
    <dbReference type="OMA" id="MLDHTRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26607" checksum="CC15C5507783C102" modified="2017-01-18" version="1">MTERLPLFPLNTVLYPGLVLPLNVFEERYRRLVADLLEQPEDEPRRFGVLAIKDGREVAPVRPEDGPAGPLDGLGTATGDPLEAIYHVGCVADVSSAQPQPDGRYELLVTGTTRFRLRSVDVSGPYLTGEIEPIEERPGEGSGALASEVERAFRVYQKRLAGAREATTHGRQQLPDDPQVLSYLVAAASVFETPVKQQLLACPDTARRLRAELDLLRRESAVLSWLPSLPAVDLTRQSFSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K6</accession>
    <name>A0A1E7N4K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0006850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281863.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene956"/>
    <dbReference type="EnsemblBacteria" id="ARF80820">
        <property type="protein sequence ID" value="ARF80820"/>
        <property type="gene ID" value="B6264_19620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35626">
        <property type="protein sequence ID" value="OEV35626"/>
        <property type="gene ID" value="HS99_0006850"/>
    </dbReference>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="32660" checksum="C1AADAB494E0F32A" modified="2017-01-18" version="1">MHDLPQQLANGLILGALYGLVAIGYTMVYGIVQLINFAHGEIVMVGGFGALTAYLALPGGTTLWLALPLMLIAGILVSTLTAVAAERFAYRPLRNAPRLAPLITAIGLSIFLQQLVFSFYPDAKKARVFPKIPGDPFSLGSVTVQRSDLFLIIAAPLCMLALGWFVTRTRSGRAMQATSQDPDTAKLMGIDTDRIIVMAFAIGAAFAAVAAVAYGLRSGQVDFRMGFILGLKAFTAAVLGGIGNIYGAMLGGLALGLAEALATGYIQHLPGMHLFGGGAWKDVWAFVLLILVLLVRPQGLLGERVADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A7</accession>
    <name>A0A1E7N5A7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7252"/>
    <dbReference type="EnsemblBacteria" id="ARF81087">
        <property type="protein sequence ID" value="ARF81087"/>
        <property type="gene ID" value="B6264_21195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35875">
        <property type="protein sequence ID" value="OEV35875"/>
        <property type="gene ID" value="HS99_0008420"/>
    </dbReference>
    <dbReference type="OMA" id="SHLVHVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="21814" checksum="9277D1216CF5F1DC" modified="2017-01-18" version="1">MIRLLIADDHPVVRAGLRAVLESEPDFAIVAEAATAERAVELAAEPGVDVVLMDLQFGPGSAMNGAQATAAITARPGAPRVLVVTTYDSDADTLPALEAGATGYLLKDAPPEELAQAVRAAAAGRSALAPSVADRLLERMRTPSAALSARETEVLGLVADGLTNQQVSQRLHLSQATVKSHLVHVYTKLGVDSRTAAVREARRRGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N642</accession>
    <name>A0A1E7N642_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284392.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000176.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8127"/>
    <dbReference type="EnsemblBacteria" id="ARF79769">
        <property type="protein sequence ID" value="ARF79769"/>
        <property type="gene ID" value="B6264_13415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36160">
        <property type="protein sequence ID" value="OEV36160"/>
        <property type="gene ID" value="HS99_0030370"/>
    </dbReference>
    <dbReference type="OMA" id="MQITMLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="531" mass="55873" checksum="5A7AC98C47B6E2E7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N649</accession>
    <name>A0A1E7N649_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5363"/>
    <dbReference type="EnsemblBacteria" id="OEV35933">
        <property type="protein sequence ID" value="OEV35933"/>
        <property type="gene ID" value="HS99_0006525"/>
    </dbReference>
    <dbReference type="OMA" id="FLPAHWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="28081" checksum="9B36CEE0FB92EBB1" modified="2017-01-18" version="1">MPLRVEAMRQLRRRRTLVIGGVLAAMPFVILAAFQIGGTPGRPDRTTFIDLATASGANFAVTMLFVGTGFMLVIPVALFCGDTVASEASWSSLRYLLAAPVPRARLLARKFAVGLAFSAVAIVMLPAIGLVVGTVAYGWGDLKLPAGASLPAGEALPRIAIAVAFVFLSELVIAALAFWLSTATDAPLGAVGGAVFLSIITGVLDAVTALGDLREWLPAHWQYAWADALQPQLEWGGMLQGVSLSLSYAVVLLVLAFRGFARKDVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6D7</accession>
    <name>A0A1E7N6D7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8100"/>
    <dbReference type="EnsemblBacteria" id="OEV36245">
        <property type="protein sequence ID" value="OEV36245"/>
        <property type="gene ID" value="HS99_0030500"/>
    </dbReference>
    <dbReference type="OMA" id="EVMVWTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="30505" checksum="F8CE6313E550D1F8" modified="2017-01-18" version="1">MPQHPALHIPDTKVVLSTASVYPASTAVAFELAAKLGYDGVEVMVWNDPVSQDLEALRRLSDAHQLPILAVHAPCLLITQRVWTTDPWTKLVRARAAAEKLGASAVVVHPPFRWQRQYAREFVEGISRMAGETDVRFAVENMYPWRYRDREVLAYSPGWDVTDEDYRHFTIDLSHVATSRIDAFAMAERMGDRLAHVHLADGSGSGKDEHLIPGRGKQPCAEFLEHLARTGFDGHVVLEVNTRRAASPAEREADLAEALAFTRLHLATPSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L4</accession>
    <name>A0A1E7N6L4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284513.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000903.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4873"/>
    <dbReference type="EnsemblBacteria" id="ARF82391">
        <property type="protein sequence ID" value="ARF82391"/>
        <property type="gene ID" value="B6264_29100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36319">
        <property type="protein sequence ID" value="OEV36319"/>
        <property type="gene ID" value="HS99_0029560"/>
    </dbReference>
    <dbReference type="OMA" id="LWWAGHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009732">
        <property type="entry name" value="DUF1304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06993">
        <property type="entry name" value="DUF1304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="13420" checksum="233D61503268DD1E" modified="2017-01-18" version="1">MNAVSQVFAMLAAAIHLVVWPLESYLYGHPRVRYMLTGSTADAPEVRLWRFNVGFYNLFLALGLVAGLVLLHTGHARSGRPVILYVAAFMVAGGITLFVSEPKVWRGALTQAVPAAVILIAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X6</accession>
    <name>A0A1E7N6X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0029245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366367.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7805"/>
    <dbReference type="EnsemblBacteria" id="ARF82266">
        <property type="protein sequence ID" value="ARF82266"/>
        <property type="gene ID" value="B6264_28370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36429">
        <property type="protein sequence ID" value="OEV36429"/>
        <property type="gene ID" value="HS99_0029245"/>
    </dbReference>
    <dbReference type="OMA" id="KWPTERI"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2141"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="3248" mass="344997" checksum="78654222C04CDF2C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N702</accession>
    <name>A0A1E7N702_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386246.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene216"/>
    <dbReference type="EnsemblBacteria" id="ARF83120">
        <property type="protein sequence ID" value="ARF83120"/>
        <property type="gene ID" value="B6264_28255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36482">
        <property type="protein sequence ID" value="OEV36482"/>
        <property type="gene ID" value="HS99_0029350"/>
    </dbReference>
    <dbReference type="OMA" id="MTRHHHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23188" checksum="4FA8369B80669A1F" modified="2017-01-18" version="1">MTNTGADPIETSNKAANAAANKPRAVTGEDVGAVSRLLARAFEDDPMMCWFFPEAATRPAALGGYFTTLFTRQYLPYGLCERTEHAAAFWVAPEAQEKAVPDEGTIRELAELLGDRAHWFRQCVEAAAANAPQEAHWYLAVLGADPVAQRRGQGAALLRSGLARADAAGLPVHLESSKAENLAVYRHFGFEVLEEVPLPGDGPTLWTMRRAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G1</accession>
    <name>A0A1E7N7G1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051746681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000908.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7757"/>
    <dbReference type="EnsemblBacteria" id="ARF82309">
        <property type="protein sequence ID" value="ARF82309"/>
        <property type="gene ID" value="B6264_28610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36608">
        <property type="protein sequence ID" value="OEV36608"/>
        <property type="gene ID" value="HS99_0027905"/>
    </dbReference>
    <dbReference type="OMA" id="TWQLALC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="903" mass="95862" checksum="672F6BC3B7E9A67C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I7</accession>
    <name>A0A1E7N7I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597664.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2509"/>
    <dbReference type="EnsemblBacteria" id="ARF81495">
        <property type="protein sequence ID" value="ARF81495"/>
        <property type="gene ID" value="B6264_23575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36667">
        <property type="protein sequence ID" value="OEV36667"/>
        <property type="gene ID" value="HS99_0028285"/>
    </dbReference>
    <dbReference type="OMA" id="TMNPRFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="22435" checksum="229F8D90A25B61D0" modified="2017-01-18" version="1">MGVRGLAEILADAAGGAFPPPDGAVTVVPQPAPREAGVLALAAHAVVFTDEDPDWVRETLAATPGDPLSAPLCPPFLTAFAERTGRTVNNIDLLTVADRLPGAPPLPLTPVQDREHPRVVRALRYREDVLVYETDGGVLILGRGVAGRWEAAVEVDPHAQGRGLGRALAVAARHLTPSGGTVWAQQAPGNAPSVRAFQAAGYRPIGAEALLVVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J9</accession>
    <name>A0A1E7N7J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278930.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2536"/>
    <dbReference type="EnsemblBacteria" id="OEV36648">
        <property type="protein sequence ID" value="OEV36648"/>
        <property type="gene ID" value="HS99_0028165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26766" checksum="9CC61C88421EC1B4" modified="2017-01-18" version="1">MSDPVVLVTGALTGIGRATAVAYARQGANLVVSGRHEDVGEQLVRELADLGAQAEFVRADVRFDAEVEELVDRAVARFGRLDVAVNNAGTEGTPCPVGEVTDERYQGIFDTNVKGTLFCLKHEFRVMREQGGGSIVNVSSCFGLMGYPEAALYVGSKHAVAGITKAAALEGAAHGVRVNAVAPGFTRTAMYERFTGDDAARDAVDSVLPMHRAGTPEEIAETVRFLGSAEASYVTGHILLVDGGLMAGGPLFPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N814</accession>
    <name>A0A1E7N814_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36835">
        <property type="protein sequence ID" value="OEV36835"/>
        <property type="gene ID" value="HS99_0027515"/>
    </dbReference>
    <dbReference type="OMA" id="MERACAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10196" checksum="2481F754DC7FD90F" modified="2017-01-18" version="1">MERACAELEAGAGGPNHQTQWSRGALAGYLWALGRGDGAPVTGVRTEGLPGNDVLTAEVDAANVALENQVERTVPRDYSQGVHDALAWVCGHTDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N881</accession>
    <name>A0A1E7N881_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386490.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000372.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6494"/>
    <dbReference type="EnsemblBacteria" id="ARF78646">
        <property type="protein sequence ID" value="ARF78646"/>
        <property type="gene ID" value="B6264_06725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36906">
        <property type="protein sequence ID" value="OEV36906"/>
        <property type="gene ID" value="HS99_0026965"/>
    </dbReference>
    <dbReference type="OMA" id="WVTEMGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="724" mass="79988" checksum="EA53405F2F6F464B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D5</accession>
    <name>A0A1E7N8D5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0027245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286971.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6801"/>
    <dbReference type="EnsemblBacteria" id="ARF78598">
        <property type="protein sequence ID" value="ARF78598"/>
        <property type="gene ID" value="B6264_06450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36952">
        <property type="protein sequence ID" value="OEV36952"/>
        <property type="gene ID" value="HS99_0027245"/>
    </dbReference>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="617" mass="65700" checksum="9D370B1911AF06DA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N9</accession>
    <name>A0A1E7N8N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556147.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7451"/>
    <dbReference type="EnsemblBacteria" id="ARF81676">
        <property type="protein sequence ID" value="ARF81676"/>
        <property type="gene ID" value="B6264_24720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37051">
        <property type="protein sequence ID" value="OEV37051"/>
        <property type="gene ID" value="HS99_0004280"/>
    </dbReference>
    <dbReference type="OMA" id="FEAWDPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="30554" checksum="8C4EC85B45BC96D0" modified="2017-01-18" version="1">MPTLPRERPEPPEPHQPSQAHEARRTAESFGADAHRYDQARPRYPDDLVARTVAGSPGPEVLDIGCGTGIAARQFQAAGCTVLGLDPDVRMADPARARGLPVEVATFEAWDPAGRTFDTVIAAQSWHWVDPAVGAAKAARVLRPNGRLAIFGHVFEPPAEVAEPFAAAFRRVAPESPFSSQPARRPLETYQAGYAKIADTIRETGRFSAPEQWRYDWDRPYTRDQWLDLLPTTGALTRLRPDQLTEILAAVGHAIDTLGGRFTMHYTTLATTATRTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8P4</accession>
    <name>A0A1E7N8P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-binding molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556150.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7453"/>
    <dbReference type="EnsemblBacteria" id="ARF81678">
        <property type="protein sequence ID" value="ARF81678"/>
        <property type="gene ID" value="B6264_24730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37049">
        <property type="protein sequence ID" value="OEV37049"/>
        <property type="gene ID" value="HS99_0004270"/>
    </dbReference>
    <dbReference type="OMA" id="EIGATCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="29745" checksum="E82434E02BA1FDB9" modified="2017-01-18" version="1">MDLNTVTEVVRRPPAQPGSLWREGDAWLAGGTWLYSAEQPGTRRLIDLTALGWAALVPGGTGLEIGATCTVRDLYAFVPPADWRAGPLLARSCEAFLSSFKVWNAATVGGNVCLSLPAGPMITLTVALEARYELWAPDGSARVVDALDFVTGDHRNVLAPGEVLRRITVPVGALRKHAAYRRFALTRLGRSTVFLVGTRTPGRDDLLLTVTAGTTRPVRLAFDTAPGARALARSIDAVPGDVWFADPNGTPEHRRHLTHHFAEEIRRELMARGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q7</accession>
    <name>A0A1E7N8Q7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556151.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7455"/>
    <dbReference type="EnsemblBacteria" id="ARF81680">
        <property type="protein sequence ID" value="ARF81680"/>
        <property type="gene ID" value="B6264_24740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37048">
        <property type="protein sequence ID" value="OEV37048"/>
        <property type="gene ID" value="HS99_0004265"/>
    </dbReference>
    <dbReference type="OMA" id="TNALGPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="238" mass="25347" checksum="D58C3046A00670D1" modified="2017-01-18" version="1">MSSTGTEQHPPTALVVGASRGLGHAMAAELLDRGWHVVGTVRDTAARTPLHDLAERADGRLTIEHLDLNDPGRLPPLRERLAHRRLDVLFVNAGITNNQRTPIGAVATADFVDVMVTNALGPMRVIEALEDLVPPAGLIGAMSSGQGSITNNTAGGREVYRASKAALNMLLRSFAARQSGTGRAFVLLAPGWIRTDLGGPDAPFTIEETVPLLVDVLLSRLGTPGLAYLDRFGRTVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X3</accession>
    <name>A0A1E7N8X3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6848"/>
    <dbReference type="EnsemblBacteria" id="ARF78640">
        <property type="protein sequence ID" value="ARF78640"/>
        <property type="gene ID" value="B6264_06685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36913">
        <property type="protein sequence ID" value="OEV36913"/>
        <property type="gene ID" value="HS99_0027005"/>
    </dbReference>
    <dbReference type="OMA" id="RWGCHQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16385" checksum="BB42E12E1B4C69A4" modified="2017-01-18" version="1">MLTQPLDAVEWMFPRLPRSAGRARIRFLRLAFEWEVPVDSAETALILLSELVTNACRHARSPRDRMIGVRVLLPTASLLRIEVSDANPELPTLRHAAPDDESGRGLELVAALASSWGAHPRGEGYIGKTVWFELALPSPACSASDHLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y1</accession>
    <name>A0A1E7N8Y1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366172.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37156">
        <property type="protein sequence ID" value="OEV37156"/>
        <property type="gene ID" value="HS99_0004880"/>
    </dbReference>
    <dbReference type="OMA" id="RCYPDPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="94"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23892" checksum="65E55682E1E2A0ED" modified="2017-01-18" version="1">MPYPIPEEFRPYYYCGDWRLGPKRLPTRGLLGNILEGYDRLGGLTAVEFLNRWWDPSLDSGEGDWKYPNDDGFEHDSMGGVLAAPLLLQAGQNLMVDRFGNESGRFFSPAGTKYGQRAIPPSSLNTIDPRYPYDYNLYRVAKDVTVCAGPAAPAFEQPGGAIQYVASSRFCPSIPFATVATLVNNGTLVRVKTTPVDEDEAQMERESAPVAGKATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N991</accession>
    <name>A0A1E7N991_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000503.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37262">
        <property type="protein sequence ID" value="OEV37262"/>
        <property type="gene ID" value="HS99_0005540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="11771" checksum="D3E52BA6E0D75672" modified="2017-01-18" version="1">MECDGLAAGDLVLAEDLQEVQVAEFAAVGLDQPRVEFSSIPDSRRTLSDLRRAVSITLIDGLLLGVIAARGALGLAGDPGGDARGEQALGPVKEGRGPGVAGLRLGVGLGAPRSGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G9</accession>
    <name>A0A1E7N9G9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MIP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0005955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556510.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5466"/>
    <dbReference type="EnsemblBacteria" id="OEV37329">
        <property type="protein sequence ID" value="OEV37329"/>
        <property type="gene ID" value="HS99_0005955"/>
    </dbReference>
    <dbReference type="OMA" id="TGGAQWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="PTHR19139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="25517" checksum="CFFF6FF5E4B3ED8B" modified="2017-01-18" version="1">MTEMAPLGRRTAVEFFGTGALVAVVVGSGIQATKLSQDVGVQLLANSLATVFGLGVLIVLLGPVSGAHFNPVVTLAAWWTGRHDGDGPSSREVAAYVPAQILGAIGGAVLTDAMFAEPLVRWSTHARWAPHLWLGEVVATAGLILLIFGLARAGRAHFAPVAVASYIGAAYWFTSSTSFANPAVTIGRAFTDTFAGIAPASVLPFIAAQLVGLVVGVALLAALFGPPAAAAAEDVVVPHGEHHPTAVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9J2</accession>
    <name>A0A1E7N9J2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556427.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82480">
        <property type="protein sequence ID" value="ARF82480"/>
        <property type="gene ID" value="B6264_29655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37365">
        <property type="protein sequence ID" value="OEV37365"/>
        <property type="gene ID" value="HS99_0006180"/>
    </dbReference>
    <dbReference type="OMA" id="GWNDTIS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="11435" checksum="8B9655FC73E9C6B1" modified="2017-01-18" version="1">MGVHIEQGAGKEACRPECLGLYDNYGFNTRDMGKVLSTDEDIPDLRDYDFNDAASSFYNNTERVVTVYKDVKYGGESLEIQPREAEDVPAGWNDTISSVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L7</accession>
    <name>A0A1E7N9L7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556391.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82493">
        <property type="protein sequence ID" value="ARF82493"/>
        <property type="gene ID" value="B6264_29730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37379">
        <property type="protein sequence ID" value="OEV37379"/>
        <property type="gene ID" value="HS99_0006255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11106" checksum="7EEA0C90E28678F2" modified="2017-01-18" version="1">MLGGLGMQLHPEKSGIVCLTRGGQGFEFPGFHHRKVESWKWRGRFYLQRWPSQRALGVLRDKIRAAASRSKTERPVAAVVAEFNPVSSLGAGASSPTRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9W1</accession>
    <name>A0A1E7N9W1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366633.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7948"/>
    <dbReference type="EnsemblBacteria" id="OEV37481">
        <property type="protein sequence ID" value="OEV37481"/>
        <property type="gene ID" value="HS99_0026030"/>
    </dbReference>
    <dbReference type="OMA" id="IPVLWEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026367">
        <property type="entry name" value="FxsC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04276">
        <property type="entry name" value="FxsC_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="464" mass="50912" checksum="B7C5B0891E9B531C" modified="2017-01-18" version="1">MSEREQQRPYFFFSYARRDFEAGDAFVDQFFNDLRDELGRILGPAVQADELAFRDTERLRLGDEWAEKLALMLGRSRTMVALYSPAYFSSLYCGKEWTAFRGRVRRHHEETAELVSALIPVLWEPVAPGELVTEVTKIQWAQPDMGDAYARHGLRALLRTAQQDAYRQVVRVVAGRIRDAAVRRLAELPEFDLDAVRGYFPGPAAPAPATEPGMVRLFIAAGRASEAAAEGGSYAGGWYGAKPWHWAPFYPPAQPSLASRAQQVITNAGHTTTLEEIGAGLGEKLDQAREDSQVSVLLVDPWAAGSERYRAALREYDDQNHPVTGVVVPIGGNDPDGEREAPWAGVRGVFRRNWLRRRDPEQLFRVKVSRESFDTDLAIMVTVAQNKLMDDNLDWGDDGGDAFGFGPGGGPDMPGLTIPAGPPDPSGPPHSPSAGRGPAPTPNDMPGQRPGSHDGSVPLRGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y5</accession>
    <name>A0A1E7N9Y5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1269"/>
    <dbReference type="EnsemblBacteria" id="OEV37293">
        <property type="protein sequence ID" value="OEV37293"/>
        <property type="gene ID" value="HS99_0005735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="14072" checksum="55E5C9FF5EDA594B" modified="2017-01-18" version="1">MTAGTVAGPVRVRVRAVLVHDGRVCLIRRQREAGHQHLLPGGLVEDGEDPIGALRRELREELGLDLAVLPAPPVLRFDQETERPGETTPFRRRRLVFTAHLPAHLVQAVAGGRAGQSRSWTRRSTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA10</accession>
    <name>A0A1E7NA10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552710.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000481.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene8004"/>
    <dbReference type="EnsemblBacteria" id="ARF79045">
        <property type="protein sequence ID" value="ARF79045"/>
        <property type="gene ID" value="B6264_09050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37526">
        <property type="protein sequence ID" value="OEV37526"/>
        <property type="gene ID" value="HS99_0026305"/>
    </dbReference>
    <dbReference type="OMA" id="KTHVANV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24517" checksum="466CEFFF4C32384A" modified="2017-01-18" version="1">MSNSARPIRILVADDQADVRSAFRMILDVQPDMTVVAEAADGAAAVQEAKRLRPDVVLADIRMPKLDGLEVTRQLADQCKVIVVTTFDLDEYVHTALRHGAAGFLLKRSGPVLLIEAVRAAMAGDALISPQITVRLLQHMAVPGSSAMPGPAAAAGVPGPLTAGPVEELTEREKEIAELVADGATNAEIGARLFISPGTVKNHLANIQRKLGARNRVGVAAWVWEQAASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL8</accession>
    <name>A0A1E7NAL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280885.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4919"/>
    <dbReference type="EnsemblBacteria" id="ARF79991">
        <property type="protein sequence ID" value="ARF79991"/>
        <property type="gene ID" value="B6264_14690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37731">
        <property type="protein sequence ID" value="OEV37731"/>
        <property type="gene ID" value="HS99_0025895"/>
    </dbReference>
    <dbReference type="OMA" id="HRFDVYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7315" checksum="A9A15C882A4BBCC3" modified="2017-01-18" version="1">MRKHRLDLFSLIAGGLFTVIAVVYLVAALNDRSVNGRIVVPVTFIVLGVGGLAGAVAAVARRGRPDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR5</accession>
    <name>A0A1E7NAR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366509.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78085">
        <property type="protein sequence ID" value="ARF78085"/>
        <property type="gene ID" value="B6264_03380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37779">
        <property type="protein sequence ID" value="OEV37779"/>
        <property type="gene ID" value="HS99_0024620"/>
    </dbReference>
    <dbReference type="OMA" id="DVHDKPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22855" checksum="050C813B8C07C565" modified="2017-01-18" version="1">MNGTQSIENPWGMSVFGAASVDAAPDLARLRVAINQTRQKPGEAFEVTRAAVNQVREALRNHNVPDSAVSTSQLDLKSSWTYGGERKFLGYECTASFVIELRELDRLETVLVDVVDAGANQVDGVTFDVQAKKELRAMARAAAVAAAREKAALYAEAAGARLGPVIHIKDIDSDHLQNSYRSHRSSGDGNGDGDLTPGKISVSAGVVIGFSLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT1</accession>
    <name>A0A1E7NAT1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">HS99_0024775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557069.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000662.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3752"/>
    <dbReference type="EnsemblBacteria" id="ARF78058">
        <property type="protein sequence ID" value="ARF78058"/>
        <property type="gene ID" value="B6264_03215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37807">
        <property type="protein sequence ID" value="OEV37807"/>
        <property type="gene ID" value="HS99_0024775"/>
    </dbReference>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="285"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV37807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="39251" checksum="C7B471C3236E42D7" modified="2017-01-18" version="1">MTDQAAIDFEAVHGARPSGVWAAPGRVNLIGEHTDYNDGFVLPIALPHTVKVTARRREDARVRLYSAQGDGTITELALDGLAPGVVTSWAAYPAGVFWALAEAGHAVGGADLFFDSDVPTGAGLSSSAALECATAAALNDLYGLGLSAPELALLAQRAENAFVGVPCGVMDQMASACCTDGTALFLDTRTLEQRHVPLDLEAAGFRLLVIDTRVKHDLGDGAYAALRAGCEQAAELLGLDALRDLPPADLTAALERLPDDLARLVRHVVTENRRVAETIEHLDGGRIAELGPILTAGHASLRDDFRVSCPETDLAVEAAVAAGALGARMTGGGFGGSVIALVATADVEAVLDAVRSAFGSAGFAAPVAFTAVPSAGARRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY1</accession>
    <name>A0A1E7NAY1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3738"/>
    <dbReference type="EnsemblBacteria" id="OEV37818">
        <property type="protein sequence ID" value="OEV37818"/>
        <property type="gene ID" value="HS99_0024840"/>
    </dbReference>
    <dbReference type="OMA" id="MESTIAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="84"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="33451" checksum="A6E684B97E6B851C" modified="2017-01-18" version="1">MRLLVRPDTVLRWHRDLVARRHAARSWPKRPGRPRTVRSIRALVLRLAAENPAWGYRRLHSELLVLGVKVAASTVWEILKEAGIPPAPERTSSTWANCLRSQADALLACDFFETVTLSGARLHVLAVIEHTNRRIRILGATAHPTASWVTQAAKNLAMDLEDAGRRARYMIRDRDGKFSELFDAVLKDAEIQVVFGGVRIPRMNSLMERWIQTCRRELLDRTLIWDQRHLLHALREFEKFYNDHRPHQGIANARPLCALPRPIDNPKQIARLDIRRTDRLGGLLHGYQHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY9</accession>
    <name>A0A1E7NAY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366500.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6012"/>
    <dbReference type="EnsemblBacteria" id="OEV37845">
        <property type="protein sequence ID" value="OEV37845"/>
        <property type="gene ID" value="HS99_0025025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8815" checksum="AC8C6A238DDD0A43" modified="2017-01-18" version="1">MWQLSRVIVSCCAADARVVDVEIHGVGTPQANTWVTVTGVWRPTAGTRVPALDVTGLTVIPQPKNPYRDAPPAPGTRPSAAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB23</accession>
    <name>A0A1E7NB23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2134"/>
    <dbReference type="EnsemblBacteria" id="ARF79441">
        <property type="protein sequence ID" value="ARF79441"/>
        <property type="gene ID" value="B6264_11380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37891">
        <property type="protein sequence ID" value="OEV37891"/>
        <property type="gene ID" value="HS99_0023715"/>
    </dbReference>
    <dbReference type="OMA" id="IKVMDQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="26622" checksum="98E1A1C90F3E6D78" modified="2017-01-18" version="1">MSIPPGKAVTRRSGIRIVGRALTCAVFALAGLLFYISAQTARGTDLRTDNSLLSLGDVIRQRSSQNQQAQAQLADLQARAQELTEQQGHDPADAAQLDGLRRGAALEPVQGGGLTVTLNDAPPNATARIPGVPEPGVNDLVIHQQDIQAVVNALWRGGAAGVQVMDQRLVSTSAVRCVGNTLLLQGRVYSPPYVIKAVGKTDALRSAVEADPTIRNYLQYVQAYGLGWKVQESGDLTLPGYSGTTELRSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA9</accession>
    <name>A0A1E7NBA9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name evidence="2" type="ORF">HS99_0024280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278377.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2023"/>
    <dbReference type="EnsemblBacteria" id="ARF79535">
        <property type="protein sequence ID" value="ARF79535"/>
        <property type="gene ID" value="B6264_11960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37980">
        <property type="protein sequence ID" value="OEV37980"/>
        <property type="gene ID" value="HS99_0024280"/>
    </dbReference>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="203"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="217"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="40395" checksum="E7494D23541F5770" modified="2017-01-18" version="1">MSGKDYVEKDYYKVLGVPKDATATEIKKTYRKLAREFHPDANTGDAKAEERFKDISEAYDVLSDEKRRKEYDEARSLFANGGFRTGGPGTGSYSFDFGDLFSGGQGGGGGGGLGDVFGGLFNRGGPRQAQPRRGADVETEVTLSFEEAVDGATVPLRMTSQAPCRLCNGTGAKSGTTPRVCPTCVGAGTVSRGQGAFALSEPCKDCRGRGMIVDDPCPDCHGSGRASSARTMQVRIPAGVQADQRIRLKGKGAQGERGGQPGDLYVTVHVDPHPVFGRKGDNLTVTVPVTFPEATLGATIEVPTLNGPAVKLKLPPGSANGLTMRARGKGATRKDGTRGDLLVTVEVVVPQHVTGDALNALEQYREATASDDPRAALFRAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM9</accession>
    <name>A0A1E7NBM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737815.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5961"/>
    <dbReference type="EnsemblBacteria" id="OEV38099">
        <property type="protein sequence ID" value="OEV38099"/>
        <property type="gene ID" value="HS99_0023145"/>
    </dbReference>
    <dbReference type="OMA" id="ARIQPEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33014" checksum="34CB435C1F0C94FE" modified="2017-01-18" version="1">MENTLGDFLRSRRARIQPEEVGLPAHGRRRVQGLRREEVAQLAGVSVDYYIRLEQGRGGSASDAVLGAVARVLRLDEVEAAHLRSLNRPPKAPAGRARGDRRVRPGTRLLLDLMTGVPAFVLGRRMDVLAWNALGDAVNGFSDRAGATAGSPPNQARDAFLDPAARDFYPQWDAVAAETVAQLRRDAGLHPDDPALAALVGELSLRSEEFRRLWADHLVREKTSGVKLLRHPLVGELEFGYETLTVNGSPDQMLVVYTAPPDSPTAQKLALLASWTAPGAAPATSPGTPPIPTPAAPPTPAAPPTPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU2</accession>
    <name>A0A1E7NBU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2065"/>
    <dbReference type="EnsemblBacteria" id="OEV37943">
        <property type="protein sequence ID" value="OEV37943"/>
        <property type="gene ID" value="HS99_0024070"/>
    </dbReference>
    <dbReference type="OMA" id="FFNIRRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42185" checksum="EDF8A117AF0DA24A" modified="2017-01-18" version="1">MSTAVLPAALELAGPSPFVVIGPGAVLDRAVPPHTAIRADQRIPAAAPTFDIRRTGDPSNRITLVLLGDGYTADEQELFRQQVDKTWHALMDIEPFRTYQGFFNIRRVEVVSPVSGIAETESHGRNPATPLGMHFWCEGTARLLCADESATARYAGDGAGPQYLIALANSTEYGGAGGTGVTTLAGGSPDAGRIIQHEIGHTVGDLGDEYDSAPDDADYPNLSTLNADDMKKKQTKWWRWLGAVSPDGAGTVGAYRSANGLYRPTPDSVMRTLGSAYNLPSREAIIEELYRRVRPTDAPSPPPGEVTGRPRLDARPLPLTGPRQLKVEWKVDGVPVSPPVADGGVLDTAQLNLVPGRTATVTATVRDTTDWVRDEAFRDRYMTRSVSWTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY3</accession>
    <name>A0A1E7NBY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0023535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene461"/>
    <dbReference type="EnsemblBacteria" id="ARF78852">
        <property type="protein sequence ID" value="ARF78852"/>
        <property type="gene ID" value="B6264_07920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38164">
        <property type="protein sequence ID" value="OEV38164"/>
        <property type="gene ID" value="HS99_0023535"/>
    </dbReference>
    <dbReference type="OMA" id="NMVEYYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="25680" checksum="3B8155B5751CC7B3" modified="2017-01-18" version="1">MTTLIKLEILRTLRNRRYLFFTVVYPALMYVFFINAYGSGNQAGGLPVKTYFMVSMATFGAVGAVLSGSAQRISLERKSGWVRQLRLTALPGRAYTVGKIASTAVTTLPAILVVFVVGATQGVSLSAPQWIGLAAALWLGSFVFAALGVALGYAAAPDAVQPIVMITYMAMALLGGTWFPVSGSLEKFARFNPVFLYNKLATFTQPGHSLDLVAVAGLAAFFAVFTAAAAALYRRDTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCH6</accession>
    <name>A0A1E7NCH6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82805">
        <property type="protein sequence ID" value="ARF82805"/>
        <property type="gene ID" value="B6264_13110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38183">
        <property type="protein sequence ID" value="OEV38183"/>
        <property type="gene ID" value="HS99_0022990"/>
    </dbReference>
    <dbReference type="OMA" id="ICAFGNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="19835" checksum="62FAB913AB8CE847" modified="2017-01-18" version="1">MTIRHGGERDAVHVADLHTESWCTSYRGIVPDEAIGDGLAVQRRELWELRLTVDYGTPENTPVLLIAERAGEPAGFVYLVPQPDGGVLVDNLHVRPGLTGGGIGRELLAAARAEVAARYPGADLYLEVLSANTRAIAFYEREGGVRIRAQEGEFPGGYLLPEYVYAWPAGPGSAPGAATADSARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCL4</accession>
    <name>A0A1E7NCL4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular small neutral protease</fullName>
            <ecNumber evidence="4">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0021955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556906.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3316"/>
    <dbReference type="EnsemblBacteria" id="ARF80267">
        <property type="protein sequence ID" value="ARF80267"/>
        <property type="gene ID" value="B6264_16325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38223">
        <property type="protein sequence ID" value="OEV38223"/>
        <property type="gene ID" value="HS99_0021955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016573">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016573-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22560" checksum="E350E95F417864F4" modified="2017-01-18" version="1">MKRSVLSATLGLGLAAALVTLPATATAVAAPAAPAVQTHTARAHSGSTHAGPQEEAVDNQAFFRAVMASARARQAAEPWLQTVTVTYDTTNAPSFTGDIANAAQIWNSSVHNVQLQETSGTGDFSYTEGDGSGSYASTDGHGHGYIFIDHQQAQEYYSLRIVAHETGHVLGLPDDYSGPCSELMSGHGPGPSCTNAHPDANESAQVDALWVNGVAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ8</accession>
    <name>A0A1E7NCQ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PaaX family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554546.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene340"/>
    <dbReference type="EnsemblBacteria" id="ARF82142">
        <property type="protein sequence ID" value="ARF82142"/>
        <property type="gene ID" value="B6264_27635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38461">
        <property type="protein sequence ID" value="OEV38461"/>
        <property type="gene ID" value="HS99_0021415"/>
    </dbReference>
    <dbReference type="OMA" id="LLIHEYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="31073" checksum="B71C83933843107A" modified="2017-01-18" version="1">MPESTARPSSLIHTVYGEFVRRLGGWISIADLIALMAELDVDAPAVRSATSRLKKAGTLLQERRAGTGYRLSPAMAPVFDEGDRRIFHSLEPAELADGWVVAVFSVPESERAHRHQLRSRLSWLGFGNAAPGVWLAPARLLPDARLLLERLGLSAYVHLFLSAEYAGFAELRTAVASWWDLPAIEAQYAAFTDAWRPLAEELRGRARIDPAEAFRDYVPMLTQWRRLPYLDPGLPEPLLPANWNAVPARAVFTEVHGLLAGPSLRFVEKVTGLSHPQELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCS5</accession>
    <name>A0A1E7NCS5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HS99_0021540</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554961.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3069"/>
    <dbReference type="EnsemblBacteria" id="ARF82123">
        <property type="protein sequence ID" value="ARF82123"/>
        <property type="gene ID" value="B6264_27505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38481">
        <property type="protein sequence ID" value="OEV38481"/>
        <property type="gene ID" value="HS99_0021540"/>
    </dbReference>
    <dbReference type="OMA" id="HNVRMRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OEV38481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="608" mass="65886" checksum="0DF0D72AB0BA3FB0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX1</accession>
    <name>A0A1E7NCX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4130"/>
    <dbReference type="EnsemblBacteria" id="OEV38333">
        <property type="protein sequence ID" value="OEV38333"/>
        <property type="gene ID" value="HS99_0022710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="10321" checksum="AC9DCB55EB240928" modified="2017-01-18" version="1">MVEVLTGARPSGQLMRHTSLDGYGQLASLVRAGALRRGGPADRPRLGPVHDRSPSPDAVEACVRVDLGRRHHMVAFRLEQRGPAGQWQCTAVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ2</accession>
    <name>A0A1E7NCZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene690"/>
    <dbReference type="EnsemblBacteria" id="OEV38555">
        <property type="protein sequence ID" value="OEV38555"/>
        <property type="gene ID" value="HS99_0019935"/>
    </dbReference>
    <dbReference type="OMA" id="YRPEVTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="31293" checksum="2EAF7251295FF670" modified="2017-01-18" version="1">MSTAAIPGAPLPVRTPGSRARGRHRRPERPEIRTGSPALVLAVPATAGPESRSVVEELLSIVRSEHAGVQAAVGYLPADGAEDGGSEDRTVAELLAAAAEAGLPTPVVVPLVPGPHDFLTGLHALAAEYGATVTDALGPHPLLAEAVHVRLSEAGLARADRARLFAIATAADGVVLTTVGGEDAAAAAGITGVLLAARLAVPVVAAALDVPGSVAGAVNHLKETGSQRPALAPLVIGPEADSELLATAAEETGCPSAAPLGAYPTVGQLIASTYLAALPTPSAEELAEAEAEAAATVGAGEGSRRAHAATEGPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND87</accession>
    <name>A0A1E7ND87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281169.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000797.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene609"/>
    <dbReference type="EnsemblBacteria" id="ARF77643">
        <property type="protein sequence ID" value="ARF77643"/>
        <property type="gene ID" value="B6264_00760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38614">
        <property type="protein sequence ID" value="OEV38614"/>
        <property type="gene ID" value="HS99_0020345"/>
    </dbReference>
    <dbReference type="OMA" id="MFAGFEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="29482" checksum="E374BC7E26A5731F" modified="2017-01-18" version="1">MRRPSWVPEGTDLDKPNAARVYDYYLGGSHNFEVDREMARKALALWPELPQIMRSNRAFLRRAVTFLAEQGITRFLDIGSGIPTFGAVHEIARAIRPGAKVVYVDRDPVAVAHSRLLLEDDPDSAVVQADLRDVEDLLDRSEVAALLAEGEPVAVLLVAVAHFVSDDENPSKLIATIRDRLPAGSALALSHASLEARPDQAEDHQKLYRMTPTPLTMRTNQQVTAMFAGFELVEPGVVPLPRWRPDQPGTVGEHPERIAGVAGVGFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC1</accession>
    <name>A0A1E7NDC1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282988.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000496.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1797"/>
    <dbReference type="EnsemblBacteria" id="ARF77710">
        <property type="protein sequence ID" value="ARF77710"/>
        <property type="gene ID" value="B6264_01135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38675">
        <property type="protein sequence ID" value="OEV38675"/>
        <property type="gene ID" value="HS99_0020720"/>
    </dbReference>
    <dbReference type="OMA" id="HREITHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14251" checksum="E497C6A09BF222D1" modified="2017-01-18" version="1">MARIFFNGQAMVGGPFHGKVADALIGPARTAPGYRFFSIDHSGGTDVCPGLLADPAVDSAIEGELYDISLERLRDVILPGEPRELELGVIKLEDGSPCLSMLLARGEVERGVHREITHHGGWRAYLATLGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDS2</accession>
    <name>A0A1E7NDS2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290288.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38805">
        <property type="protein sequence ID" value="OEV38805"/>
        <property type="gene ID" value="HS99_0019245"/>
    </dbReference>
    <dbReference type="OMA" id="KERTHFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="17129" checksum="5E9D865A98AC61A6" modified="2017-01-18" version="1">MDPMLSCRWRDQDGEWELSVRHNGSDWELFAAAPLWSESLPFAGPDEVRRLAQALLDLPADPEPYEFEWELSRTEFARTEKERTHFATFAVGLDPTDDHRPYLAYQSYHQLGQATGLGLEVICEDPPVDHLRAQAHAFLTNCPGPPPLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE50</accession>
    <name>A0A1E7NE50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I-E CRISPR-associated protein Cse1/CasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481441.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4342"/>
    <dbReference type="EnsemblBacteria" id="ARF83209">
        <property type="protein sequence ID" value="ARF83209"/>
        <property type="gene ID" value="B6264_30160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38981">
        <property type="protein sequence ID" value="OEV38981"/>
        <property type="gene ID" value="HS99_0017895"/>
    </dbReference>
    <dbReference type="OMA" id="CHTATAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="58336" checksum="AA668088307CDB08" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE67</accession>
    <name>A0A1E7NE67_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555419.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6499"/>
    <dbReference type="EnsemblBacteria" id="ARF83002">
        <property type="protein sequence ID" value="ARF83002"/>
        <property type="gene ID" value="B6264_22335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38928">
        <property type="protein sequence ID" value="OEV38928"/>
        <property type="gene ID" value="HS99_0019600"/>
    </dbReference>
    <dbReference type="OMA" id="TRMTWTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038764">
        <property type="entry name" value="GNAT_N_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41700">
        <property type="entry name" value="PTHR41700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29319" checksum="749A0E255A0F2F80" modified="2017-01-18" version="1">MVEFPSAVAERADVRIQLLRTVPELQQAEAVLRTVWNTPDLAEPPLALDVMCALAHTGGYVAAAYLGTAMVGVTAGFRTIGDSLHSHVAGVLPGMHGRGIGAAMKSHQREWAAEVGLSSISWTYDPLIRRNAYFNLHRLGAVAEAYLPDFYGPLDDGINDGDDSDRLFVRWPVHATPHAPAPPPLPDPAAAEPVLEEDGNGEPLPRAATGGVLRCATPVDAESLRRRDPAAARRWRSAMREALGGALENGYRIDGFDRSGWYVLRRKEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE87</accession>
    <name>A0A1E7NE87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558247.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83171">
        <property type="protein sequence ID" value="ARF83171"/>
        <property type="gene ID" value="B6264_29945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38948">
        <property type="protein sequence ID" value="OEV38948"/>
        <property type="gene ID" value="HS99_0017690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19700" checksum="00F48AAFE9DFE0A7" modified="2017-01-18" version="1">MLPLAATNGLAFSLSLHGHHEQAEQVLLPVLEEASQQGLGRFLMVLHLGAARALTGQGRAQEALAAVDQAQDTFDRTPGAGALTQDLSALLLARSAALLASSRPADAEHEARRCLSQCERRLGPAHHRALEAATVLGTALADLHRNDEAVELLHATHDAWRTHFGHDHHGTIRARQLLAALTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER7</accession>
    <name>A0A1E7NER7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83211">
        <property type="protein sequence ID" value="ARF83211"/>
        <property type="gene ID" value="B6264_30170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38983">
        <property type="protein sequence ID" value="OEV38983"/>
        <property type="gene ID" value="HS99_0017905"/>
    </dbReference>
    <dbReference type="OMA" id="KCHFAHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="665" mass="72876" checksum="2E025F486D6C0B3D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF88</accession>
    <name>A0A1E7NF88_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288842.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1544"/>
    <dbReference type="EnsemblBacteria" id="OEV39370">
        <property type="protein sequence ID" value="OEV39370"/>
        <property type="gene ID" value="HS99_0001285"/>
    </dbReference>
    <dbReference type="OMA" id="YMENEDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199075" evidence="2">
        <location>
            <begin position="32"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="604" mass="62815" checksum="DFC85AE8916807BE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ1</accession>
    <name>A0A1E7NFJ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000619.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7554"/>
    <dbReference type="EnsemblBacteria" id="OEV39442">
        <property type="protein sequence ID" value="OEV39442"/>
        <property type="gene ID" value="HS99_0001705"/>
    </dbReference>
    <dbReference type="OMA" id="QWCVEDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15194" checksum="AE189B1E50FB3F87" modified="2017-01-18" version="1">MKAEDLMTAPPVTVRPATTAFEAALVMEREAVGCVLVTDHGRLCGILTDRDLTVRVLAHGPHPAQPVAELMTTPVVTVAGDADLDTAYRSFRNTGVRRLPVLDGDRPVGMLTVDDLLRDVVERLLDLLIPVSRSALRESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM3</accession>
    <name>A0A1E7NFM3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285895.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5095"/>
    <dbReference type="EnsemblBacteria" id="OEV39474">
        <property type="protein sequence ID" value="OEV39474"/>
        <property type="gene ID" value="HS99_0001905"/>
    </dbReference>
    <dbReference type="OMA" id="TAWIADH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007804">
        <property type="entry name" value="Gas-vesicle_GvpG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05120">
        <property type="entry name" value="GvpG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="9559" checksum="3911E572694D7844" modified="2017-01-18" version="1">MGLITQILTLPLAPVRGTVWVLERVVETAEDEYYDPAPVENDLAELERALLAGEIDEETFDRREDELLDRLDEIRAHTQRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN0</accession>
    <name>A0A1E7NFN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556237.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39506">
        <property type="protein sequence ID" value="OEV39506"/>
        <property type="gene ID" value="HS99_0002100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12797" checksum="2AEC6FFE9973C827" modified="2017-01-18" version="1">MRAAAAVCGRAQHPPLIRVDDHDGEGSPHLHLAPNGEDAVTWLGRSCAAALAHVVCGDLAVTIGHRHAADCERFQGRVEADHASLSPRRVARLLLTDPDHLHEEQLVLRDQLAGAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFR5</accession>
    <name>A0A1E7NFR5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555653.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6775"/>
    <dbReference type="EnsemblBacteria" id="OEV39527">
        <property type="protein sequence ID" value="OEV39527"/>
        <property type="gene ID" value="HS99_0002230"/>
    </dbReference>
    <dbReference type="OMA" id="FQNAFRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32840" checksum="9B27D77069645918" modified="2017-01-18" version="1">MTNPRILPGTAHPTLGDAVSEALGTEPVECEVERFPDGELQPVVGHVRGEDVYVVQPTGRDVKEHLIELLLLLDACRRAGTRRVTAVVPYFGYARQDRRTRAGQSVGARVALDALAAAGADRLVVVDPHTPTLEAMSSIPVETLSAVPLLAAALAEHTPAAAVVVSPDLGAVKLAEHYGELLGRPVAIVRKTRLSGSNVKAEELVGDVVVRPAVIVDDMISTGGTVRAAVKVLLAHDAAPDITVAATHPLLGDRATDRLARLPISRLVVADTVPPPRIPTLPHRVRTVAPLLAEAIALPHGGEPLDTLLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG75</accession>
    <name>A0A1E7NG75_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279458.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2875"/>
    <dbReference type="EnsemblBacteria" id="OEV39719">
        <property type="protein sequence ID" value="OEV39719"/>
        <property type="gene ID" value="HS99_0003405"/>
    </dbReference>
    <dbReference type="OMA" id="LTGNGMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="32399" checksum="2D55E91351DC1BEE" modified="2017-01-18" version="1">MSTAAASEAGTWKLGDLEVNRIGYGAMRLTGNGMMGNSDGTPIDRDAAVRLLHSAFEQGVDHVDTASFYFSPLRSANELINRALASWNGDVVVVTKVGPGRDPSGEWLTMARPDQLRGQVEENLRQLGRDHLDVVNLRRNGPGTASIAEHFGALAELREAGLIRHLGISNVRPEHLAEARAIAPVVCVQNSYGLDWRRADESGMVDLCREQGVAFVPYFAIAGRRREAPAVRERDARVHTVARAHGATPAQVRLAWTLHRGPHVLAIPGTTSPGHLAQNIAAGALRLTEEELALLDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA2</accession>
    <name>A0A1E7NGA2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480378.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2855"/>
    <dbReference type="EnsemblBacteria" id="OEV39702">
        <property type="protein sequence ID" value="OEV39702"/>
        <property type="gene ID" value="HS99_0003310"/>
    </dbReference>
    <dbReference type="OMA" id="CDERESY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="14"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26205" checksum="353075527E15FBF7" modified="2017-01-18" version="1">MTGQWQELGTPGGIEAYVHRPAGEVRGAVVVCSELYGVNAYLRRVCAELADLGYVAVAPDFYWRNARRTELGYGAEEREAGLVLMTALDRDELVADAAAALDAARALADGHGVAFFGMSMGGHIAVRAATELRFELAAVYYPGWLLNSGFPLVGPVPPLETAERIAANGVYLLGFCGELDHILPQEEWREAERRLTDAKVGHELVTYPGARHGFAADRPADHDATATADAWRRVRGALAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB5</accession>
    <name>A0A1E7NGB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279441.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000628.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2867"/>
    <dbReference type="EnsemblBacteria" id="OEV39714">
        <property type="protein sequence ID" value="OEV39714"/>
        <property type="gene ID" value="HS99_0003370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199117" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="7035" checksum="AAB9C5E58E11F506" modified="2017-01-18" version="1">MITSSLARLAVLFAATAVLVLAGSAPARALPRDVTAEQCQNNGGTVQGGGYCVGATGEDEWGADIDGQGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF1</accession>
    <name>A0A1E7NGF1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555609.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6741"/>
    <dbReference type="EnsemblBacteria" id="OEV39553">
        <property type="protein sequence ID" value="OEV39553"/>
        <property type="gene ID" value="HS99_0002395"/>
    </dbReference>
    <dbReference type="OMA" id="LMIVESC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18713" checksum="C6896B517378DA53" modified="2017-01-18" version="1">MHTVIVYESMYGDTREIAEAIAEGIHQADPRAAVDCLPVAEADMETTRSADLLVVGGPTHMHGMSSGLSRRMAVAAEAHKQDREPAAAEARETAEGPGLRAWFHDLPQAGSGACAAAFDTRVDMPRAGGAANGIARRLSGHHYEMVAEPEGFIVEDNDGPLRTGELARARAWGAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SRP2</accession>
    <name>A0A176SRP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006335</name>
        <name evidence="4" type="ORF">HS99_0017740</name>
        <name evidence="3" type="ORF">HS99_0019580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000228_gene6785"/>
    <dbReference type="EnsemblBacteria" id="ARF81270">
        <property type="protein sequence ID" value="ARF81270"/>
        <property type="gene ID" value="B6264_22315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82506">
        <property type="protein sequence ID" value="ARF82506"/>
        <property type="gene ID" value="B6264_29810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83180">
        <property type="protein sequence ID" value="ARF83180"/>
        <property type="gene ID" value="B6264_30000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37392">
        <property type="protein sequence ID" value="OEV37392"/>
        <property type="gene ID" value="HS99_0006335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38865">
        <property type="protein sequence ID" value="OEV38865"/>
        <property type="gene ID" value="HS99_0019580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38957">
        <property type="protein sequence ID" value="OEV38957"/>
        <property type="gene ID" value="HS99_0017740"/>
    </dbReference>
    <dbReference type="OMA" id="NREHEFH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="35075" checksum="CAE7653B97755422" modified="2016-09-07" version="1">MKLIDEHQDRFGAEPVLRELHIPASTYYRWRRDVAEPCERKRHDAELTEHIRRIHADSDETYGSPRVHAVLRREGTRVGRKRVERLMRQAGIQGVSPRRPRSFTRRDPAADLAPDLVQRDFTAVAPNRLWVADISLIPTGEGPWWLATIRDAFSRRIVGWHTSERADADLVLTALEYALHGRPVEPGQLVHHSDHGCQYTSIKLTTRLLKAGIEPSMGSVGDSFDNALAENFWSVLKTECVRRTTFETRTDADLALFAYIDGWYNTRRIQKRLGWLSPDEYEAKFYADQATAEPVTVEPPTPVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP1</accession>
    <name>A0A1E7MVP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386587.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2959"/>
    <dbReference type="EnsemblBacteria" id="OEV32500">
        <property type="protein sequence ID" value="OEV32500"/>
        <property type="gene ID" value="HS99_0016185"/>
    </dbReference>
    <dbReference type="OMA" id="ATHCRIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="37112" checksum="73CA832B54078F5C" modified="2017-01-18" version="1">MLGTGMLVFPTLTAVAVSGDVGGSAAVAGLAVVIAFSLCYVLLALALGRERRSFVKPLLAAMTALFLASLPFAHADAFFLATVIVSVVAVLWRRHTLPVVAAGTVAALLVPWAVPAWHTGPGGFQALALLFTSLTCGAFAEIAATNRALVAARAEVARLASEAERNRIARDLHDLLGHSLTAITVKSRLAHRLAAKDLDQAVAEMAAVESLSRQALADVRAAVTGYREVTIAGELARGRELLRAAGVVADLPKAADAVGPEQRELFGWVVREGITNVVRHARASRCSVLLTPTSVEIRDDGPGGAGRGLIGAGKGLTGLRERVAAVGGTVEAGPLDPRGWRLLVTVRQADPRSEGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC5</accession>
    <name>A0A1E7MWC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285503.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7834"/>
    <dbReference type="EnsemblBacteria" id="ARF78225">
        <property type="protein sequence ID" value="ARF78225"/>
        <property type="gene ID" value="B6264_04215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32735">
        <property type="protein sequence ID" value="OEV32735"/>
        <property type="gene ID" value="HS99_0015870"/>
    </dbReference>
    <dbReference type="OMA" id="ATTAMKY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="10867" checksum="CDA01DE3BFF2140B" modified="2017-01-18" version="1">MPYVLLALAILSEVCATSCLKLTEGFTRLWPSLGVGVGYALSFFLLGRALKHIPVSVAYAVWSGAGTAAVAGIGVVAFGESLGKLQILGIALIIVGVVVLNLKGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE5</accession>
    <name>A0A1E7MWE5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0015980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7812"/>
    <dbReference type="EnsemblBacteria" id="OEV32751">
        <property type="protein sequence ID" value="OEV32751"/>
        <property type="gene ID" value="HS99_0015980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198493" evidence="2">
        <location>
            <begin position="41"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="28112" checksum="AF848F98F6CBFF39" modified="2017-01-18" version="1">MVTDSWPALHGRPVLRRTVAVSLVLSISVAAALVVRGVNALTVGGVGGRETDRDRAERLAGLHPSQHPGAGRYYVPVGAVYTRTSDGAPIAYLHYRLGGGKEPGLDDFLRTYDLPEPGPAAPLPPDLAAALGGDEPAQAPELPEEPAPAPSGPSGPAVSAAPGSPQASAVPLAIAAEPTPTPTPTPTPTPTEDDPDGAGGMGGAGGAGGVAADGEPEEDAPGDGAPSPSATPTRTPTPGPTPTWTPTATPSAVPTHAPTARRIYVAAIPGGLPGAADIYIRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI8</accession>
    <name>A0A1E7MWI8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557641.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7830"/>
    <dbReference type="EnsemblBacteria" id="OEV32805">
        <property type="protein sequence ID" value="OEV32805"/>
        <property type="gene ID" value="HS99_0015890"/>
    </dbReference>
    <dbReference type="OMA" id="LKREWRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30583" checksum="44EDBB7D6501A642" modified="2017-01-18" version="1">MQTGAPRPAGRRARGSRAWLAALPLVLFFAIGFGLPAVAIAVGAFTTSSDAPDGGGTFTTDNLTGSLQGAYWTALWGSVKLSLLTALIATVVGLPLAQAVATSRFRAFREAVMSASGVLANFGGVPLAFMFVATLGNSGEVTRKLGLTEHGWNLYTFSGLSVVYLYFLVPLMVITITPALEGLKAQWREAASNNGATSLQYWRHVALPVLLPSLLGGFVLLFGASFAAYATAEAMVGSSVPLISMQIGDALSGNVLVGQGNLALALGLDMIVVACLVMALYLPLQRRSAKWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWN0</accession>
    <name>A0A1E7MWN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000083">
        <property type="protein sequence ID" value="OEV32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000530.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4121"/>
    <dbReference type="EnsemblBacteria" id="ARF80136">
        <property type="protein sequence ID" value="ARF80136"/>
        <property type="gene ID" value="B6264_15520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32837">
        <property type="protein sequence ID" value="OEV32837"/>
        <property type="gene ID" value="HS99_0039875"/>
    </dbReference>
    <dbReference type="OMA" id="NIHGEGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24913" checksum="43B62D3E3AE01C83" modified="2017-01-18" version="1">MKGRVLVVDDDSALAEMLGIVLRGEGFEPFFVADGDKALAAFRESKPDLVLLDLMLPGRDGIDVCRQIRAESGVPIVMLTAKTDTVDVVVGLESGADDYVTKPFKPKELVARVRARLRRAEEPTPEQLTIGDLVIDVAGHSVKRDGRSIPLTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKIEKDPERPEIVVTVRGVGYKAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ2</accession>
    <name>A0A1E7MWZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5743"/>
    <dbReference type="EnsemblBacteria" id="ARF81380">
        <property type="protein sequence ID" value="ARF81380"/>
        <property type="gene ID" value="B6264_22915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32966">
        <property type="protein sequence ID" value="OEV32966"/>
        <property type="gene ID" value="HS99_0013885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8789" checksum="27779AFEE6A59BEC" modified="2017-01-18" version="1">MTHDMAPPLLAVAVLLLIIKLARQRRNGKPLPLVPRSVPARVTGVAVLALVVVSGVAGGQPWDASLVPAVSLGGLAGAFVDLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX66</accession>
    <name>A0A1E7MX66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552452.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5674"/>
    <dbReference type="EnsemblBacteria" id="ARF81443">
        <property type="protein sequence ID" value="ARF81443"/>
        <property type="gene ID" value="B6264_23260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33027">
        <property type="protein sequence ID" value="OEV33027"/>
        <property type="gene ID" value="HS99_0014230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="28292" checksum="4940A2CE6AA8BBB9" modified="2017-01-18" version="1">MAMVWSPGWARSLVEGGQARREPAGPLGPVVRVHRGFRPVPRRARAWLDAVAALLALVLCRSLGEWWPAPVVAAVAVVAVSGYGRLRPAPRLRSVRLHQGGLALVGADGSERLLRWGEIEAAEYAPGGQRGEPERGRIWPAGADEPLVLAQLRGLDGLFREVDERLSPGLRAALHEALRTEGSVRFDRGRLTVTVGGLVHRPPHPLAATEAYRWAEVHSARASDLGELEIRTHSAGLPLTLPVPNARAAAEFLEEVRARSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC0</accession>
    <name>A0A1E7MXC0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552401.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000267.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33082">
        <property type="protein sequence ID" value="OEV33082"/>
        <property type="gene ID" value="HS99_0014575"/>
    </dbReference>
    <dbReference type="OMA" id="HIHIGCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="39522" checksum="F4F796466232C6E2" modified="2017-01-18" version="1">MLTIGVEEEYLLIDPVTGVPVSRASRVVQAAARRSALTEGEVQREVSQAQLEVATPVCRSLDEVGGHLLRLRLSLGEAAEACGCRLAAVGSAPFVDRLAVPVTPTPRYLRMRRQAPALTDEQLINGMHVHVGVRDPDDRVTVLNALRPWLPVLTALAANSPMWRGRDTGFASWRTIVFDRWPVAGLPPRFTDAADYDHRSGELVRTGLIGDTGQLYWQARLSQHYPTVEVRAMDVQLHVDEAVLLAGLVRALAARALEGAGPASDRPPEFLRATAWYAARHGAVGTLHDPLSNRMLPAREVTAGLLAHLAGPLRESGDRARVARLIEQLHRGGNGAVRQRRELRHHGRRGLIRAVVDQTAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXG6</accession>
    <name>A0A1E7MXG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000537.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2674"/>
    <dbReference type="EnsemblBacteria" id="OEV33135">
        <property type="protein sequence ID" value="OEV33135"/>
        <property type="gene ID" value="HS99_0014905"/>
    </dbReference>
    <dbReference type="OMA" id="PVGYWGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="27548" checksum="A8F75425F512BC9E" modified="2017-01-18" version="1">MNAFLLTAESTTDGIVERDFTVNGVPGVLWSPESGADHAPLVLQAHGGGNHKKHPAMSGRAAHLVRDCGYHVAVLDAPGHGDRPRTEHDERETAALFAARAAGEPEGPIVVRYNDHLAKLAVPEYRALLDALQQLPEIGTDGPVGFWGINMGTAIGVPFVAAEPRITAAVFGQHWPHVLAEYAKRITVPVEFDLQWDDEHISREEGLALFEAFASAEKSLHVNSGKHKELPRFEVESAVRFFARHLGRAVNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH8</accession>
    <name>A0A1E7MXH8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550943.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2697"/>
    <dbReference type="EnsemblBacteria" id="OEV33114">
        <property type="protein sequence ID" value="OEV33114"/>
        <property type="gene ID" value="HS99_0014785"/>
    </dbReference>
    <dbReference type="OMA" id="DVPLVWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="19085" checksum="981DA60D28DCCC9A" modified="2017-01-18" version="1">MSTDNRPVPSLTGGEREMLRGFLDFHRATLAMKCEGLTDQQLRERSSPPSTLSLLGLVRHMAEVERTWFRRVIDGEDVPLVWSEDGDYQVAYDATGATRAEAFAAWRAEVEHSRRIELAAPSLDVTGYQPRWEAEVSLRLVMLHLIHEYARHNGHADFLREAIDGVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK3</accession>
    <name>A0A1E7MXK3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16S/23S rRNA (Cytidine-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290943.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene11"/>
    <dbReference type="EnsemblBacteria" id="ARF78126">
        <property type="protein sequence ID" value="ARF78126"/>
        <property type="gene ID" value="B6264_03630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33180">
        <property type="protein sequence ID" value="OEV33180"/>
        <property type="gene ID" value="HS99_0039455"/>
    </dbReference>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28314" checksum="5243A10233EE95AA" modified="2017-01-18" version="1">MARRRLDAELVRRKLARSREHASELIAAGRVTVGGTTATKPATQVETSAAVVVAKDENDPDYVSRGGHKLAGAFAAFVPQGLVVEGRRALDAGASTGGFTDVLLRAGAAHVLAVDVGYGQLAWSLQSDERVTVMDRTNVRELTREMIGGTPVDLVVGDLSFISLGLVLPALAGCAAEDADLVLMVKPQFEIGKERLGSGGVVRSPELRAEMVRQVAGQAWQLGLGVRAVTASPLPGPSGNVEYFLWMRRDAPQLDPAEADRAVAEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM8</accession>
    <name>A0A1E7MXM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552424.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5629"/>
    <dbReference type="EnsemblBacteria" id="ARF83020">
        <property type="protein sequence ID" value="ARF83020"/>
        <property type="gene ID" value="B6264_23480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33161">
        <property type="protein sequence ID" value="OEV33161"/>
        <property type="gene ID" value="HS99_0014450"/>
    </dbReference>
    <dbReference type="OMA" id="FKPNGKP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="952" mass="102670" checksum="32C8D09ECE0C8CA4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY21</accession>
    <name>A0A1E7MY21_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="6" type="ORF">HS99_0011985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030058248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7020"/>
    <dbReference type="EnsemblBacteria" id="ARF80415">
        <property type="protein sequence ID" value="ARF80415"/>
        <property type="gene ID" value="B6264_17215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33314">
        <property type="protein sequence ID" value="OEV33314"/>
        <property type="gene ID" value="HS99_0011985"/>
    </dbReference>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8883" checksum="B169FED246798FA0" modified="2017-01-18" version="1">MAHKKGASSTRNGRDSNAQRLGVKRFGGQVVSAGEILVRQRGTHFHPGAGVGRGGDDTLFALTAGAVQFGNRRGRKVVNIVAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB2</accession>
    <name>A0A1E7MYB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290307.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000088.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7108"/>
    <dbReference type="EnsemblBacteria" id="OEV33223">
        <property type="protein sequence ID" value="OEV33223"/>
        <property type="gene ID" value="HS99_0039250"/>
    </dbReference>
    <dbReference type="OMA" id="MGDTTAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="9972" checksum="0A6A754648EF306C" modified="2017-01-18" version="1">MPPAARSGDPTDHGGALTTPPPGALAVETVLIGGRPAAVVGSLHACVPHVEMGPANLVEPELGTVTRGVTLIGGFPAARMGDKTTCGAAILGGAFNVLIGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR0</accession>
    <name>A0A1E7MYR0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549975.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5254"/>
    <dbReference type="EnsemblBacteria" id="ARF80673">
        <property type="protein sequence ID" value="ARF80673"/>
        <property type="gene ID" value="B6264_18745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33568">
        <property type="protein sequence ID" value="OEV33568"/>
        <property type="gene ID" value="HS99_0013525"/>
    </dbReference>
    <dbReference type="OMA" id="AYFDCGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="647" mass="68220" checksum="9B48470FA043B1B3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS0</accession>
    <name>A0A1E7MYS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385894.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3410"/>
    <dbReference type="EnsemblBacteria" id="ARF82884">
        <property type="protein sequence ID" value="ARF82884"/>
        <property type="gene ID" value="B6264_17345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33578">
        <property type="protein sequence ID" value="OEV33578"/>
        <property type="gene ID" value="HS99_0012115"/>
    </dbReference>
    <dbReference type="OMA" id="GWLWAAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="44575" checksum="6BD6114414641202" modified="2017-01-18" version="1">MSGAGGTGRTGRWRRTGRKRLGPQFGWLWAAYAVSAYGSGLGFGALPLIAVLALHAGPAEVSALSAVGPAVGALIAVPLAPWVEFRRKRPVMIAMDLVRCAAMATIPLAYALGLLGFVQLLVVSAVVAAAKIAFNAASGAHLKALVRPDDLLVANARFESTNWSSIAVGPPLGGAAIGLFGPVTTVVADALSYLLSALGITAIRGREETPQPTAKAPVRAGALLDGWRHILGDTGLRALYLNNMLVSGLIMATEPLLAVLLLRQLHFPAWQYGLAFAAPCLGGLIGSRLARHVVARYGRHRVFRTVGTLRAVWLIGLVFVRPGVVGLVTVMAVELAIIVNMSLYTPVLATYRLERTPKHLVARTLSAWSIGQQASIAVCTALGGLLADATGPRTALAVAGLLILATPLLLPRREQAQEPEAALSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS4</accession>
    <name>A0A1E7MYS4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549980.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5261"/>
    <dbReference type="EnsemblBacteria" id="OEV33574">
        <property type="protein sequence ID" value="OEV33574"/>
        <property type="gene ID" value="HS99_0013560"/>
    </dbReference>
    <dbReference type="OMA" id="TPPPGWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="36348" checksum="A5423F773BB2242B" modified="2017-01-18" version="1">MSNSTPPGWYPVPGADGAPGHERWWDGNAWTSEVRPLQGGAGQVADAPTQTWQPSTPQHQQQPGYGYPAQSGSPAPGYGYPGQDAAQGPGYGYPGQTPYPGQSPYPGQEAYPGAAYGYPPPAGPGRSRTGVIVGIAVAVLVVGGIIAGLVLSNGGDPKAGPTPNPTVTVTQSDSPSPRPTPTRPSPTSKPVPTLKSTVPDPQHAITVPVFDGWDAAANSAHSTVYLGSGRYTCADGNSCIRGQFSIEKDTVQGDTPKGAADAAMPAYAGTIFSGISSHTDSGSGYVSVAGVLGYATRWHVRTSDGTQGYVLLAAVPAKGGGYVVFEGGVDDDPAAPDASVLDQILKGIKQDSSSGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ82</accession>
    <name>A0A1E7MZ82_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386931.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000572.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82663">
        <property type="protein sequence ID" value="ARF82663"/>
        <property type="gene ID" value="B6264_06300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33760">
        <property type="protein sequence ID" value="OEV33760"/>
        <property type="gene ID" value="HS99_0037975"/>
    </dbReference>
    <dbReference type="OMA" id="MERDDQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="62" mass="6979" checksum="AAD05F1499B3933E" modified="2017-01-18" version="1">MAERLKQAHARVHALNVSVDAKTALTRQLLIVTETAKRDLPEAARRLSRFVHDLDEGHPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW8</accession>
    <name>A0A1E7MZW8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0011015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280244.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2209"/>
    <dbReference type="EnsemblBacteria" id="ARF77837">
        <property type="protein sequence ID" value="ARF77837"/>
        <property type="gene ID" value="B6264_01860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33979">
        <property type="protein sequence ID" value="OEV33979"/>
        <property type="gene ID" value="HS99_0011015"/>
    </dbReference>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="43660" checksum="FED89F7F1F02750D" modified="2017-01-18" version="1">MSTPRSWLTSAQDSPFGVHNLPYGVFTAADRPGQRRIGVRVGDFVLDAGAAARAAGAASALLAADSLNPLMAAGRSVWTQVRNDLTTWLTDESFREAISPALVPVGEVELHLPFEVADYVDFYASEHHATNLGRIFRPGSEPLTPNWKHLPIGYHGRAGTVVVSGTPVVRPHGQRKAPADAVPSFGPSRRLDIEAEVGFVVGVPSELGRPVTLDDFREHVFGVCLVNDWSARDIQAWEYVPLGPFLGKSFATSVSPWIVPLDALQHARVSPPERDVEPLAYLDDRGGEPWGLDLAMEVRLNGHLVSRPPFAGMYWTAQQQLTHMTVNGASLRTGDLFASGTVSGPEPDTRGALIELTWNGEEPLKLPDGTTRTFLEDGDEVVITATAPGPDGVVVGFGEVSGQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S5</accession>
    <name>A0A1E7N0S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283690.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2583"/>
    <dbReference type="EnsemblBacteria" id="OEV34282">
        <property type="protein sequence ID" value="OEV34282"/>
        <property type="gene ID" value="HS99_0036775"/>
    </dbReference>
    <dbReference type="OMA" id="GDQVTHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8297" checksum="DCE83F144D5D5D75" modified="2017-01-18" version="1">MTKFAASRRPLPTSPFKPRPEALPKHFTVGDRVTHDGYGLGRVIGVEGDGDVAVLVDFGSRQERITHPYTAMFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V5</accession>
    <name>A0A1E7N0V5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">HS99_0036630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7644"/>
    <dbReference type="EnsemblBacteria" id="OEV34312">
        <property type="protein sequence ID" value="OEV34312"/>
        <property type="gene ID" value="HS99_0036630"/>
    </dbReference>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="148"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="381"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="501" mass="54855" checksum="788C5DD7DC912153" modified="2017-01-18" version="1">MVSGESGLKSYKVVTHGCQMNVHDSERLSGLLEDAGYVKAGPDGDPDLVVFNTCAVRENADNKLYGNLGQLAPAKSRHQGMQIAVGGCLAQKDRETIVKRAPWVDVVFGTHNIGHLPALLERAAVERRAQVEILESLETFPSTLPTRRESAYAAWVAISVGCNNTCTFCIVPALRGKEEDRRPGDVLAEIEALVDEGVIEVTLLGQNVNAYGSDLGDREAFSKLLRAAGQIEGLERIRFTSPHPRDFTDDVIAAMAETPSVMHQLHMPLQSGSDRVLKAMRRSYRQERFLGIIRKVREAMPDAAISTDIIVGFPGETEEDFEETMHVVREARFTNAFTFQYSKRPGTPAAEMEDQVPKEVVQARYDRLIALQEEISWDENKKQVGRTLEVLVAEGEGKKDDRTQRLSGRAPDNRLVHFTKPEEPVRPGDMVTVEITYAAPHHLLAEGPALAVRRTRAGDAWEKRQAEPAGKPAGVMLGLPKIGAPAELPLAAPAGGACCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y2</accession>
    <name>A0A1E7N0Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6422"/>
    <dbReference type="EnsemblBacteria" id="OEV34350">
        <property type="protein sequence ID" value="OEV34350"/>
        <property type="gene ID" value="HS99_0036450"/>
    </dbReference>
    <dbReference type="OMA" id="GGPWINT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198634" evidence="2">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="31789" checksum="53025397517AFC2E" modified="2017-01-18" version="1">MLAPSLFTALSAVVVATVVAGTHGFDLSDATAAGKEARSPRAVAVAPATSPAATTAAPASPAPAADTTPSRTPTPAPSATPTPTDSPSSTAPATPDAHSVVLGATGPAPADNRETATVGALFSGSVAPGNHFCTASVLHSATGNLLLTAAHCLTSTDGVTFAPGYRDGSAPYGTWRVTAIHTASGWSEKGDVDEDFAILETAPSNGRKVEDVVGGNKLGTDEPFGATVRLYGYPADAEVPNLCTNTTAQQSAYQRVIQCPSYPSGTSGGPWINTATGDVVGAIGGYQQGGDTDDTSYSAYFDHTVAELYDQAEAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1K2</accession>
    <name>A0A1E7N1K2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">HS99_0035290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5570"/>
    <dbReference type="EnsemblBacteria" id="ARF79347">
        <property type="protein sequence ID" value="ARF79347"/>
        <property type="gene ID" value="B6264_10820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34556">
        <property type="protein sequence ID" value="OEV34556"/>
        <property type="gene ID" value="HS99_0035290"/>
    </dbReference>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="46345" checksum="CC6BE149CAACA42C" modified="2017-01-18" version="1">MSTAARRAFFDRTHTDDLITFLGTSPSPYHAVASAAQRLEKAGFRQVAETDAWDGSVGGRYLIRGGALIAWYVPEGAGPETPFRIVGTHTDSPNLRVKPVPDTGSAGWRQVAVEIYGGVPLNTWLDRDLGLSGRLALKNGSARLVQLDEPLLRVPQLAIHLDRQVNDGMKLDRQRHLTPIWGLGPVDEGSLIAYVAERAGLAAEDVAGWDLMTHDVQPASYLGRDRELLAGPRLDNLLSVHAATAALAAVAVAAAEGEAVLPYIPVLAAFDHEETGSESDTGAQSPLLGNVLDRTVHARGGSPEDRARALAGTVCLSSDMGHAVHPNYSERHEPGHHPLPNDGPILKVNVNNRYATDGVGRAVFAAACEKAGVPWQTFVSNNAMPCGTTIGPITAARLGIKTVDCGIAALSMHSARELCGAEDPYLLASAIKAFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M2</accession>
    <name>A0A1E7N1M2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552796.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5558"/>
    <dbReference type="EnsemblBacteria" id="ARF79358">
        <property type="protein sequence ID" value="ARF79358"/>
        <property type="gene ID" value="B6264_10875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34566">
        <property type="protein sequence ID" value="OEV34566"/>
        <property type="gene ID" value="HS99_0035345"/>
    </dbReference>
    <dbReference type="OMA" id="PHDPGHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="433" mass="44763" checksum="79815546B4B7C828" modified="2017-01-18" version="1">MDEPLVRPRSLTREAAGLRVGVPGLPEHVERFCALVDRVDPLLHAFVAEPGRHDRLQARARELAARYPESAGRPPLYGVAVGVKDIVHVDGLPTHGGSALPPGVLAGPQAVVVDRLLAAGAMVAGKTVTAEFAASAPGPTRNPHHPGHTPGGSSSGSAAAVAAGLVPLAIGTQTVGSVIRPAAYCGVVGFRPTHGRIPFAGVIPNAPSFDTLGLFTADLAGAALAAPLLCDGWRVVEPGPEPVLGVPDGPYLERAEPAALRAFEEQVARFERAGLAVRRVPLFPDFAEVTRQLQIVNRFELARSHADWFARFGGLYRPETAASIRVGQGVAAEDREAALGFRERLRERVAGAAAAAGVDLWLAPSAPGGAPEGLHSTGDAVMSLPWSCLGLPALSLPAGRTPDGLPLGLQVVGAAGEDERLLARAALLEGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1X6</accession>
    <name>A0A1E7N1X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34676">
        <property type="protein sequence ID" value="OEV34676"/>
        <property type="gene ID" value="HS99_0009300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SMART" id="SM00634">
        <property type="entry name" value="BID_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="179"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Big-1" evidence="2">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="45978" checksum="42ECD9C27114C64D" modified="2017-01-18" version="1">MAACSAFTATATGAPVGAVTAVFFYDGAAPQSLPVVAGAAGPATFTAVGSGAQLVLVTYLNAVAAVVGTDSGTVTVNAAPAGTISTTLSIGVGGLVTAQTTLTCSAGLTSVNGTLTYTLPGGGTVTAPVVNGVVGPASLGLALTAGQLVGVSFTPAAGTCAACTFAPITVTVPAPLACSVVVIQPVAPVVVGQPTVVSAVVLCNGVPVAGAAVTFNGDGAAPVTVTTNALGIASGSMTFPTAGPVSLTATVTAAGTTCTCTNVVSLPVTVTVTPPATCQVFLLPPVAPVVVGQPTVVSAVVLCNGVPVAGAAVTFNGGGAAPVTVTTNALGIASGSMTFPTAGPVSLTATVTAAGTTCTCTNVVSLPVPITVGVGGPAVSLQALPSCWQGHWEHAPATPSHGQPYPFTATLKAQLTPAAAGVTVNFLVAGQPVGSAVTDASGIAILTTDLNLLQVQSGAFTATATVGGTPLQSTGTLLPCRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z9</accession>
    <name>A0A1E7N1Z9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555925.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4641"/>
    <dbReference type="EnsemblBacteria" id="ARF81919">
        <property type="protein sequence ID" value="ARF81919"/>
        <property type="gene ID" value="B6264_26240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34719">
        <property type="protein sequence ID" value="OEV34719"/>
        <property type="gene ID" value="HS99_0009535"/>
    </dbReference>
    <dbReference type="OMA" id="RIWGGIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16000" checksum="29C4932F80B3690F" modified="2017-01-18" version="1">MTTAASTTTAPVATAPVADARGLALAHYAARGVLEQVLARHGATFQQQVALRAAVTADAPQTPDDLVAQVRGSLKADPAEIRATVEELLAEQLLVADGAHLRPTEAGRELLAAVSAETAPISARVWGAIPAEDLAAAGRVLALVTERANAELAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A5</accession>
    <name>A0A1E7N2A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556982.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3223"/>
    <dbReference type="EnsemblBacteria" id="ARF81832">
        <property type="protein sequence ID" value="ARF81832"/>
        <property type="gene ID" value="B6264_25685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34806">
        <property type="protein sequence ID" value="OEV34806"/>
        <property type="gene ID" value="HS99_0010055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9907" checksum="0651C7EF0CFD099E" modified="2017-01-18" version="1">MAAALHGRAAASGARLSLAPVTAERGRRRWQWALELNAGPGHDTLLTVLTDSRLPLGLELWRRECTCGQPVSAGCALFLTRTCTHVITGGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H3</accession>
    <name>A0A1E7N2H3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34887">
        <property type="protein sequence ID" value="OEV34887"/>
        <property type="gene ID" value="HS99_0009910"/>
    </dbReference>
    <dbReference type="OMA" id="TERSEVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13527" checksum="1C07D61E3A67E8F7" modified="2017-01-18" version="1">MERVIDLDEAAAELTDRAPGWRAAGLTVGRVTWRDETAPWPQRLEVNRSLVNDPDAVGVLVSGPAEAELSVALFRGGWADVDYVVGMDDASALPASGIASAREFGIQLDSWVAHVFGQLSCSSESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N310</accession>
    <name>A0A1E7N310_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554326.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene414"/>
    <dbReference type="EnsemblBacteria" id="ARF78891">
        <property type="protein sequence ID" value="ARF78891"/>
        <property type="gene ID" value="B6264_08155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35089">
        <property type="protein sequence ID" value="OEV35089"/>
        <property type="gene ID" value="HS99_0034060"/>
    </dbReference>
    <dbReference type="OMA" id="SIWSADI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27253" checksum="6D97D324987A0AC5" modified="2017-01-18" version="1">MTGSSGDKQPKYQRIADSLKAAIDTGRYRAGDRLPGENDLMDEYGVARMTARQALGVLQSEGIAEARRGAGVFVRDFRPLRRRGIQRLAQGQWGSGRSIWSADIDNRSLVVDQVSVTEQGAPDHVAGVLGVEPGVPMCVRHRRFVLDGKPVLLSTSYLPAVLVAGTAITREDTGPGGTYARLAEIGAKPVHFREEVRSRMPAAEEAARLELSAGTPVILICRTAFADEGQVVELNEMILDAASYVLEYGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N347</accession>
    <name>A0A1E7N347_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737944.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83089">
        <property type="protein sequence ID" value="ARF83089"/>
        <property type="gene ID" value="B6264_26875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34873">
        <property type="protein sequence ID" value="OEV34873"/>
        <property type="gene ID" value="HS99_0008915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025959">
        <property type="entry name" value="Winged_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13592">
        <property type="entry name" value="HTH_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="19290" checksum="7C26EEEE11700960" modified="2017-01-18" version="1">MEAAELFDEGVPPKEVARRSRVTTKSAYQWHQAWREGGAGALASRGPGGQRCKLSARCRAKLAEYLEQGPAVHGWDKDQVWTGARVATLIGRKFHVSYSVSGATRLMQRLGFTPQVPTRRAAERDEQAVAAWMEVTWAEVKAPGRPATDGSASRMKPGSPADRPRHARGDAVASPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N377</accession>
    <name>A0A1E7N377_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0033805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000209.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4462"/>
    <dbReference type="EnsemblBacteria" id="ARF78438">
        <property type="protein sequence ID" value="ARF78438"/>
        <property type="gene ID" value="B6264_05450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35159">
        <property type="protein sequence ID" value="OEV35159"/>
        <property type="gene ID" value="HS99_0033805"/>
    </dbReference>
    <dbReference type="OMA" id="ATGGVRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="816" mass="87900" checksum="596FDF8374790F33" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F5</accession>
    <name>A0A1E7N3F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556702.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000681.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6150"/>
    <dbReference type="EnsemblBacteria" id="ARF79291">
        <property type="protein sequence ID" value="ARF79291"/>
        <property type="gene ID" value="B6264_10520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35228">
        <property type="protein sequence ID" value="OEV35228"/>
        <property type="gene ID" value="HS99_0033485"/>
    </dbReference>
    <dbReference type="OMA" id="GHLYAPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="34469" checksum="2C3AD1E6E0AB1E7A" modified="2017-01-18" version="1">MDLDLGQVRAFVTTAEELHFGRAATRLAISQQGLSKRIARLEAALGLRLLERDARGVALTAAGTRFLGPARRVLTQGDLAVAAAQETGRPLRIDVWGHLYAPMRTLAQAVDAAPGLEVEPVPGRDLPSVAAALLRGEADAGFGRVHALPDGADAGLTHRLVRLEPVDALLSADHPLADRDTLSPAELRSSVLRYPAAVDRLDFLTRFAARFDVTARVGSTNLGLEHFLDQVAADPGCFSLVPADGPLPDRPGVRTVPLADPTPLYAWSLLWRTDRAPESDGQLDRLLRAFTAEAARSRWLEYDPSRDWLPDADEAALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q0</accession>
    <name>A0A1E7N3Q0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000774.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5324"/>
    <dbReference type="EnsemblBacteria" id="ARF80732">
        <property type="protein sequence ID" value="ARF80732"/>
        <property type="gene ID" value="B6264_19095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35307">
        <property type="protein sequence ID" value="OEV35307"/>
        <property type="gene ID" value="HS99_0033155"/>
    </dbReference>
    <dbReference type="OMA" id="WEIEILT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="7897" checksum="14F290896A7689F7" modified="2017-01-18" version="1">MTETTPAETAPTDIALTVNGEPRRLPAATTLAALVATVSAANTGVAAALNEAVVPRSSWSATALHSGDRIEILTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N487</accession>
    <name>A0A1E7N487_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0031915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5511"/>
    <dbReference type="EnsemblBacteria" id="OEV35507">
        <property type="protein sequence ID" value="OEV35507"/>
        <property type="gene ID" value="HS99_0031915"/>
    </dbReference>
    <dbReference type="OMA" id="TEFAYFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="38138" checksum="2BB3D7C8E9310449" modified="2017-01-18" version="1">MAAAAGVSITTVSDALNGKGRLPDETRSRVREVAERLGYRPSAAARTLRTGRSGLIGLTVTTYGEEPFTFTEFAYFAEMARAATSAALGRGYALVVLPASSRHDVWGNIALDGTVVIDPPDQDPLVSELYRSGVPVVSDGKPGNCPVTAWVDNDHEAAVLGILDHLSEAGARRIGLLTGTSTDTYTRLSTEAYLGWCTKVGQEPVYEAYPAHDPAAGAVAADRLLARPDRPDAVYGLFDPNGTDLLAAARRYGLRVPDDLLLVCCSESDVYAATEPPITTLSLKPRKIGTTVVNLLIDAIEGVDSGTGVDIARLFPPRFRTAGNGPPPGTLMPTELIVRASSQRRSPRTTVSAPRPPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4I6</accession>
    <name>A0A1E7N4I6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="9" type="ORF">HS99_0006720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281917.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene981"/>
    <dbReference type="EnsemblBacteria" id="ARF80799">
        <property type="protein sequence ID" value="ARF80799"/>
        <property type="gene ID" value="B6264_19490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35606">
        <property type="protein sequence ID" value="OEV35606"/>
        <property type="gene ID" value="HS99_0006720"/>
    </dbReference>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="27947" checksum="F2784214AA4AD60B" modified="2017-01-18" version="1">MSVLDSIIEGVREDLAERQARVSLDELKALAAKAPEAKDGVAALKGDGVRVICEVKRSSPSKGALASIADPAALARDYAAGGAAAISVLTEQRRFGGSLADLDAVRAAVDTPVLRKDFIVTAYQLWEARAHGADLALLIVAALEQPALVSLIERAESIGLTPLVEVHDEDEIKRAVDAGARIIGVNARNLKTLEVDRSTFENVVHAIPDGVVKVAESGVRGPLDVINYANLGADAVLVGESLVTGKDPRAAVADLVAAGAHPAVRHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J5</accession>
    <name>A0A1E7N4J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551229.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene983"/>
    <dbReference type="EnsemblBacteria" id="ARF80798">
        <property type="protein sequence ID" value="ARF80798"/>
        <property type="gene ID" value="B6264_19480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35605">
        <property type="protein sequence ID" value="OEV35605"/>
        <property type="gene ID" value="HS99_0006710"/>
    </dbReference>
    <dbReference type="OMA" id="GAFMVMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9034" checksum="A1C04CCB155EF7BB" modified="2017-01-18" version="1">MSAAAHGHNPAAWTGVVISFAGFGIAGVAMILPSPLLVWAGLAVVLVGGIVGKAMSMAGMGKQPSANVYKSVEEQTAARKAAVESRATVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U4</accession>
    <name>A0A1E7N4U4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="1">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000646.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene876"/>
    <dbReference type="EnsemblBacteria" id="ARF80894">
        <property type="protein sequence ID" value="ARF80894"/>
        <property type="gene ID" value="B6264_20025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35692">
        <property type="protein sequence ID" value="OEV35692"/>
        <property type="gene ID" value="HS99_0007250"/>
    </dbReference>
    <dbReference type="OMA" id="GWIENAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="17850" checksum="9789514F597C760F" modified="2017-01-18" version="1">MSTTVYTTMESPLGRLLLSGVLPEGGGAAALATVTAPGQKYALAEPADGWEFDPEALAEPVAQLTAYFSGERTTFDLPLAPEGTEFRRRIWAALDEVPYGTTVTYGRLAELAGESPRMVRAVGGAVGANPLLIVRPCHRVLGANGSLTGFAAGVDRKRRLLELESGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W5</accession>
    <name>A0A1E7N4W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene834"/>
    <dbReference type="EnsemblBacteria" id="ARF80927">
        <property type="protein sequence ID" value="ARF80927"/>
        <property type="gene ID" value="B6264_20240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35725">
        <property type="protein sequence ID" value="OEV35725"/>
        <property type="gene ID" value="HS99_0007470"/>
    </dbReference>
    <dbReference type="OMA" id="GARWHRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21455" checksum="FF5DB2933BDA9DDA" modified="2017-01-18" version="1">MREEQPYWNTNVARHAGILRAVPPECGAALDVGCGDGLLAAKLARRCGRVVGVDSSAGMVARARALHAEPTFLEGDFLTVDLPAEGFDFVCSVTAVHHMDFTAALTRMRELLCPGGVLVVVGLAREETAADWARRVAAAPLVRTVKVLRRAGGPTGMPEAAPGMGYRRVREAAEQVLPGVRYRWHLLRRYSLTWRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N511</accession>
    <name>A0A1E7N511_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80972">
        <property type="protein sequence ID" value="ARF80972"/>
        <property type="gene ID" value="B6264_20515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35762">
        <property type="protein sequence ID" value="OEV35762"/>
        <property type="gene ID" value="HS99_0007740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11896" checksum="06EFB289B55A1566" modified="2017-01-18" version="1">MDYHYIGTLANMLPGTDWLPVGDIAQRYVDVATSDWANKVNAAIDTKAQGDLSSLYTTGQSQMQVMLQRKAADMGVPSRDVLLDQLTDSAKVHYYTSITQAHNAAFGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D6</accession>
    <name>A0A1E7N5D6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyl-gamma-aminobutyrate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553606.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7267"/>
    <dbReference type="EnsemblBacteria" id="ARF81099">
        <property type="protein sequence ID" value="ARF81099"/>
        <property type="gene ID" value="B6264_21270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35888">
        <property type="protein sequence ID" value="OEV35888"/>
        <property type="gene ID" value="HS99_0008495"/>
    </dbReference>
    <dbReference type="OMA" id="PTYHHQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="25408" checksum="D7D9C4D06466B254" modified="2017-01-18" version="1">MDRRPFIGVSTYLVDASWSDWRGRRVALLPERYTAYVQRSGGIAVLLPPDSPERAPEVLARLDALVIAGGPDIDPAYYGESAHPLTDVASPERDLWEVALLRGALAAGMPVLGICRGMQVLNVVCGGTLVQHLPDVVDVDVHGGSPGCYGAHVVRPVPGTLVGGLLPESELEVPTFHHQAVGRLGAGLRVSALAPDGTVEAVEGPGFTVGVQWHPEQGDDLRVMRALVQAATAAALDAVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N617</accession>
    <name>A0A1E7N617_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formimidoylglutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281060.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5012"/>
    <dbReference type="EnsemblBacteria" id="ARF80077">
        <property type="protein sequence ID" value="ARF80077"/>
        <property type="gene ID" value="B6264_15160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36132">
        <property type="protein sequence ID" value="OEV36132"/>
        <property type="gene ID" value="HS99_0031180"/>
    </dbReference>
    <dbReference type="OMA" id="MCPTTER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02022">
        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="47405" checksum="084BAFC1FF1704BB" modified="2017-01-18" version="1">MPVSYWAQYAWLPHPNGPVVEQDVLITTGPDGRIVRVEPDSGPCPSGAVRLDGLLLPGQANAHSHAFHRALRGHVQVGSGTFWTWRDTMYRFAGALDPDSYLELATAVYAEMALAGISAVGEFHYLHHAPGGARYTDPNAMGEALIEAAARAGIRITLLDTCYLSSGFGAEPTHPQLRFSDGDAEAWAVRADALKPREHARIGAAIHSVRAVPAEQLGTVAHWSAMRGAPLHVHLSEQTAENDACLAAHGVTPTRLLADHGALGPRTSAVHATHLTDEDVTLLADSSTTVCMCPTTERDLADGIGPARRLASAGSPISLGSDSHAIIDPWEEARALELDERLRTRTRGHWTANALLRAGGEDGHASLGWPEAGRIEAGALADFTAITLDSVRTAGPPPRLGAEIAVFAASAADVRHLVVGGRHVVRDGVHQLVADVPGALRSAIGALDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N651</accession>
    <name>A0A1E7N651_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284347.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000634.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8105"/>
    <dbReference type="EnsemblBacteria" id="ARF79788">
        <property type="protein sequence ID" value="ARF79788"/>
        <property type="gene ID" value="B6264_13520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36177">
        <property type="protein sequence ID" value="OEV36177"/>
        <property type="gene ID" value="HS99_0030475"/>
    </dbReference>
    <dbReference type="OMA" id="VIRSWEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="14481" checksum="FF5F96017DA90C85" modified="2017-01-18" version="1">MAGGSTGAADGGSGGFVLKPWELHGEGREFEKLGRELGKAVSTLEQGLAALGAPWGADQPGSALAAVYGPAHGELLGGLRALAGQVGQVGAGLHTMAERTTDTDTSTADGFGGTPAPTAGTPGSVARPAVYSGTGATPGAAPAVPQDMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C6</accession>
    <name>A0A1E7N6C6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8072"/>
    <dbReference type="EnsemblBacteria" id="ARF79817">
        <property type="protein sequence ID" value="ARF79817"/>
        <property type="gene ID" value="B6264_13695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36204">
        <property type="protein sequence ID" value="OEV36204"/>
        <property type="gene ID" value="HS99_0030640"/>
    </dbReference>
    <dbReference type="OMA" id="HVPINAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="80" mass="7738" checksum="CF4C09FBEFCCFC9B" modified="2017-01-18" version="1">MRNFKKAAVLSLATTGLVFGAAGGAFASAGAEGVAAGSPGVISGNQIQVPIHIPLNVCGNSIDAVGLLNPAFGNTCVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q8</accession>
    <name>A0A1E7N6Q8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553203.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5025"/>
    <dbReference type="EnsemblBacteria" id="ARF80088">
        <property type="protein sequence ID" value="ARF80088"/>
        <property type="gene ID" value="B6264_15225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36143">
        <property type="protein sequence ID" value="OEV36143"/>
        <property type="gene ID" value="HS99_0031245"/>
    </dbReference>
    <dbReference type="OMA" id="MYGERYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="672" mass="72567" checksum="01940E6C07083DC0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R7</accession>
    <name>A0A1E7N6R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Drug:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386856.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000543.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7187"/>
    <dbReference type="EnsemblBacteria" id="ARF82338">
        <property type="protein sequence ID" value="ARF82338"/>
        <property type="gene ID" value="B6264_28780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36369">
        <property type="protein sequence ID" value="OEV36369"/>
        <property type="gene ID" value="HS99_0029875"/>
    </dbReference>
    <dbReference type="OMA" id="WYFPRTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="47451" checksum="60E2C5B177DD3D1F" modified="2017-01-18" version="1">MPGPDQQVRPERQPTAPTEDSADVIVVGAGPAGSTAAYHLARTGLDVLLLEKSAFPREKVCGDGLTPRTVKQLVDMGIDVSEEAGWLHHRGLRLISGHRSMEFDWPELSAFPGHGLVRRRADFDELLARKAAAAGARLVERANVAGPLTDERSGRITGVSVKLGEERRPVEYRAPIVVAADGNSTRLSVAMKRYRRTDRAMGVAYRTYFTTPRHDDRYLEAWLDLRDSNDPARRLLPGYAWVFGMGDGTANVGLGVLDTTGTDLDWRDLLRRWCADLPPGYAYTPEAVTEPIRGSALPMGLNRQPHYADGLLLIGDAGGTVSPGTGEGIAYAMESGRYAAETIVQAHARRTDRGRELALRAYPQKLRSAYAGYFALGRLAADLLGRPRLLGAAGAAGLGHPALLKVAFRLMVNLTEPNSKDALDRLLHLIGRVAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C6</accession>
    <name>A0A1E7N7C6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1471"/>
    <dbReference type="EnsemblBacteria" id="OEV36596">
        <property type="protein sequence ID" value="OEV36596"/>
        <property type="gene ID" value="HS99_0028700"/>
    </dbReference>
    <dbReference type="OMA" id="QFNGDTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="35757" checksum="F359880C06980D62" modified="2017-01-18" version="1">MEGAVLGHGAGNPDPRTAYGYREDHSGGSFDGPPPPPPMPPEPPTLLGHPSGSEGPGGHGNRARRGLLRGRLALVTAVAAIAAVIGGVTGGVVAADRQSSDSRVGTIASPVSARTDGTANVPAIASAVSPSVVQITVKSGNGTATGTGVVLNHNGQILTNFHVIDTAADGNGRITVTFKDGSTAPATVTGTDKKLDVAVITATGAKNLSPAVLGDSSTVAVGDPVVAIGNPDGLTGTVTSGIISAENRDVTVQLDEGSTSGNGGFGFPNLPGLRGSIPQQQSGADTTTYKAFQTDAALNPGNSGGPLINANGQVIAINSAMYAPNGASSTAGGGSSTAGSVGLGFAIPINDIKQALPKLEAGQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L0</accession>
    <name>A0A1E7N7L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0028245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2518"/>
    <dbReference type="EnsemblBacteria" id="OEV36659">
        <property type="protein sequence ID" value="OEV36659"/>
        <property type="gene ID" value="HS99_0028245"/>
    </dbReference>
    <dbReference type="OMA" id="YRRWTLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="7">
        <location>
            <begin position="51"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="53735" checksum="6895DD3991A8437F" modified="2017-01-18" version="1">MTEPAQPAQPTESTPSIRYRKNGLTRGVTEELAESMKHGWADTERHALEPVPQAAHTERRRAELSAAFPGELLVVPSGNPKVRANDTDYPFRPSSDYVYLTGDQSQDAVLVLEPTGDSGHRAVLYLRDRSDIESGEFWLDGHGELWDGRRNSLTESERLFGLPCRDVRTVCADLAAATAPVRVLRGHDAGVEETLRDRTTAERDADFEVFLSGMRLVKDEFEIAQLRLACQATARGFEDVVRVLGTDAATPERLIEGTFFVRARLEGNDVGYSTIAAAGPHATTLHWVRNNGQARPGDLLLLDAGVETNELYTADVTRTLPVSGRFTDIQRKVYDAVHAAQEAGIAAVRPGADFRDFHHAAQRELAEHLTAWGLFGDLTADKVYELGLHRRFTLAGTGHMLGIDVHDCAHSRTEEHVDGTLLPGMVLTVEPGLYFQENDLTVPEEYRGIGVRIEDDILVTEDGNENLSADLPRGSEEVEAWLARLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N5</accession>
    <name>A0A1E7N7N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2525"/>
    <dbReference type="EnsemblBacteria" id="OEV36654">
        <property type="protein sequence ID" value="OEV36654"/>
        <property type="gene ID" value="HS99_0028210"/>
    </dbReference>
    <dbReference type="OMA" id="AAWKHSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="53611" checksum="FA9793C580B038C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8I4</accession>
    <name>A0A1E7N8I4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553008.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4820"/>
    <dbReference type="EnsemblBacteria" id="ARF82437">
        <property type="protein sequence ID" value="ARF82437"/>
        <property type="gene ID" value="B6264_29365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36783">
        <property type="protein sequence ID" value="OEV36783"/>
        <property type="gene ID" value="HS99_0027645"/>
    </dbReference>
    <dbReference type="OMA" id="WQSYVET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="469" mass="49915" checksum="C534B985E8636BC5" modified="2017-01-18" version="1">MPLEWSSSPPELLLAVDRTSGQPLRAQLEHGLRDAIRAGRLHVGERLPSSRELARTLGLSRGLVQECYAQLLAEGYLVTRPGSATRVAAGAAAPPGAARPRSTASHLVADFRWGVPDLGSFPVQDWLWAMREAAHAMPTAEFDYGDPRGSAGLREVLAGYLRRVRAAAADPEHIVVCNGYAQGLGLALRVLADGGARTVAFEDPGSPATVRDAAAVAGLRAIPVPVDEHGIDVSALAATDARAVVVTPAHQWPTGVALTPERRLALTEWARDRDAIVIEDDYDAEFRYDREPVGALQGLAPDRVISLGTVSKSLAPALRIGWMVCPADLVEPLTERKHRSDRGTPTLDQLALARLIESGRFDRHLRRMRATYAARRAALLAALAEHAPELPVTGLAAGFHAVAHLPAGADEHHIVTAARARSVGLYGISTCRASRTITPAQLVLGFGNVGERAITEGIAAVGHLLTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T6</accession>
    <name>A0A1E7N8T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386159.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000242.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81629">
        <property type="protein sequence ID" value="ARF81629"/>
        <property type="gene ID" value="B6264_24415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37099">
        <property type="protein sequence ID" value="OEV37099"/>
        <property type="gene ID" value="HS99_0004575"/>
    </dbReference>
    <dbReference type="OMA" id="VRNDSHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="19278" checksum="3F0FCF89F0C42843" modified="2017-01-18" version="1">MNKMTTAIVLAASAAVAVTGISYASAASEPVTKAAPVVEKAAPAAVPAQAPLDGGTKGNEGKGNEGHERREHREHREHRGVIHVNERSYSADDFGCITVVSGLGAKSLNVRNDSHRTVEVFSGAVCDNGAPIATVGPHSSSDGVHPKRVHEGVEVDDGVVGSFRVVHHDYGFGGRGGERGGERGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N944</accession>
    <name>A0A1E7N944_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385551.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000097_gene50"/>
    <dbReference type="EnsemblBacteria" id="OEV37211">
        <property type="protein sequence ID" value="OEV37211"/>
        <property type="gene ID" value="HS99_0005235"/>
    </dbReference>
    <dbReference type="OMA" id="RTKQFYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="236"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="610" mass="68054" checksum="3F56C03BE280A2BC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B7</accession>
    <name>A0A1E7N9B7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555126.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1276"/>
    <dbReference type="EnsemblBacteria" id="OEV37286">
        <property type="protein sequence ID" value="OEV37286"/>
        <property type="gene ID" value="HS99_0005700"/>
    </dbReference>
    <dbReference type="OMA" id="MHEDRTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21846" checksum="AD3526EE617FB2E9" modified="2017-01-18" version="1">MDVPKLLEAASLLVPEEIATENDITINDVWDYLTHDEWEVALGLLEELGDVHPLPLSFWETLATAAEHMQLKNSAAWCHWRCYETRNGIIRADLTLRPASESRRQIPFSGAGVLRPMWNIGNRTPTGEPTLNIAALWVESTPFLGPGERASVRLAPLDPSQWRHLQSGQTIAMHEDRTVAGTAVVLEVHAPTATPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C6</accession>
    <name>A0A1E7N9C6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1271"/>
    <dbReference type="EnsemblBacteria" id="OEV37291">
        <property type="protein sequence ID" value="OEV37291"/>
        <property type="gene ID" value="HS99_0005725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23420" checksum="2457EAD9B6013F2D" modified="2017-01-18" version="1">MTAPAQVAYDDILRVWREADGIEQIEHAWLFVHLMPLGGWIAVEHQGPGKPGRVVVGTLADRRPSPPPTSPWTCSTSPAGTWPTPSHPAPLATAARTPAVPMPNLTLGQTTGRTAPTDRGLGDAHRDYALGDGLVHLTWPTAPHIQALERRGRLLGWTEVDDDNNSWITLINGHPIADAADNLPLLSTNPTDALTLLRLAVERGLSGIAPGWVLPRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9J0</accession>
    <name>A0A1E7N9J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5435"/>
    <dbReference type="EnsemblBacteria" id="OEV37356">
        <property type="protein sequence ID" value="OEV37356"/>
        <property type="gene ID" value="HS99_0006110"/>
    </dbReference>
    <dbReference type="OMA" id="VLWRKPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26928" checksum="39CE82AA7AB8DA51" modified="2017-01-18" version="1">MDEVKVIVAHSERATLRVGDVFLKVDADQARIDVEVEAMSLAPVPTPEVLWRKAPVLAIAALPGTVLGRLGEPSTASPAAWAAAGAAIRKLHEAPLPPWAGRRRRSPDELVAELDGECDLLVTNGVLPADLVTRNRQVAEAALRPWIPAFTHGDLQIDHVFVDGDEVTGIIDWSEAGRGDALFDLATLTLGHEEHLDDVIAGYGTDVDLDVIHAWWSLRSLLGVRWLVEHGFDPFAPGCEVDVLRSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K3</accession>
    <name>A0A1E7N9K3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37324">
        <property type="protein sequence ID" value="OEV37324"/>
        <property type="gene ID" value="HS99_0005925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198907" evidence="2">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="9528" checksum="690369CBCBF897BF" modified="2017-01-18" version="1">MMLHCWLLAPVQVASTMGAPSSVRASATSRHLPLKSAWISTVELDDSGGNDDAEAGAAASRPAPRPRASTAMLERMFMVPPMEPYVSGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P3</accession>
    <name>A0A1E7N9P3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556558.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6164"/>
    <dbReference type="EnsemblBacteria" id="OEV37203">
        <property type="protein sequence ID" value="OEV37203"/>
        <property type="gene ID" value="HS99_0005175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198911" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="202"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="36511" checksum="7228548ADA293808" modified="2017-01-18" version="1">MKTILPARRHWSLGLALAAALTGFGAYTASAATAPAPIPITSPACPANLQQGEADGCVTQLQAELNLTGAHLTVDGQFGPATDSAVRTFQGAHRLTADGIVGPATKSALDAAAAAASGTVDLRTQCGNLQTGASGQCVSTLQTMLNTFNAGRLVVDGQFGPATDTAVRNFQAAQGLAIDGIVGTGVKNALYTGTPAPLPSGPIDSTRVLNAAKSYLGVPYVWGGGHSLRGEGPGPSLGTCDGYTGSIQPCPANTTVGVDCSGLVRAAFWFGAGIDLAGGGDTTEQTLDKHLTPITEAQRQPGDVEYFGTDAHNTVHVVLYAGTDSATGADMMYEAKETGTNVHYVTLRTGGYWYHVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U3</accession>
    <name>A0A1E7N9U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737834.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7928"/>
    <dbReference type="EnsemblBacteria" id="OEV37465">
        <property type="protein sequence ID" value="OEV37465"/>
        <property type="gene ID" value="HS99_0025935"/>
    </dbReference>
    <dbReference type="OMA" id="PYTAWWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="938" mass="99578" checksum="61BC8CFDF2D8F2BA" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD9</accession>
    <name>A0A1E7NAD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0167 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385675.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37453">
        <property type="protein sequence ID" value="OEV37453"/>
        <property type="gene ID" value="HS99_0005920"/>
    </dbReference>
    <dbReference type="OMA" id="YLCPWCI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005363">
        <property type="entry name" value="UPF0167"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03691">
        <property type="entry name" value="UPF0167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19024" checksum="2E48B425B2CA085E" modified="2017-01-18" version="1">MREPLPVFPYHPDPVATGAIVQSDTECSCCGRARGYIYAGPVYAAENLRDRLCPWCIADGSAADRFEAQFTDVVDDVPMDRLFAITQRTPGFSGWQQERWLIHCADGAAFLGPAGAAELAAYPDASASLRQELTSWPKPQAEQYLNALTRDGQPTAYLFQCRACGTHLAYADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK2</accession>
    <name>A0A1E7NAK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280871.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4912"/>
    <dbReference type="EnsemblBacteria" id="ARF79984">
        <property type="protein sequence ID" value="ARF79984"/>
        <property type="gene ID" value="B6264_14650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37725">
        <property type="protein sequence ID" value="OEV37725"/>
        <property type="gene ID" value="HS99_0025860"/>
    </dbReference>
    <dbReference type="OMA" id="CEDGAAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="37683" checksum="2DA23A4B42776925" modified="2017-01-18" version="1">MRGGPGQLMAGRYRLTDRPELLRAFAVDEHTGESVLLRAVELPALLTAGQDPEEPNPGHGDRLVRRVAAVGSAAPAWHPRLLRGVGAFVDGELLWTVEERPAGWTLAELLTAGPLPPYRAAELAADLAGALRALHEAGLSHGNVAAESVLVCEDGAAMLGGLLDGVAQEALAEDLGGPGGRRRYEVRATLVGPVAERWPLDGGPAGDCWALGVLVQRMVAGRPPFPEVGVPELVTAVREGRREPSVVCGPLAPLAERLLQPDPTLRPTARAVQGELAALLASAPEPADEERVAREVELKPEAPLVPLRPRRRGRSGGVAPESGAARGGGSPRIPPALLGPLLVGGVFLLLVLGIVAVVLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT6</accession>
    <name>A0A1E7NAT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78065">
        <property type="protein sequence ID" value="ARF78065"/>
        <property type="gene ID" value="B6264_03255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37801">
        <property type="protein sequence ID" value="OEV37801"/>
        <property type="gene ID" value="HS99_0024740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9582" checksum="8515233708D1C52D" modified="2017-01-18" version="1">MPVEPGLFFLTFPGELSLAIELSALFDLAEDLGECVFEPPSLPVSPTVSTAPVRPGGLDAEFQLVGGLCGPGGHALPGVLHAVDIKDLDGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV6</accession>
    <name>A0A1E7NAV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598824.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000201.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37798">
        <property type="protein sequence ID" value="OEV37798"/>
        <property type="gene ID" value="HS99_0024725"/>
    </dbReference>
    <dbReference type="OMA" id="EWVSTEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="702" mass="77267" checksum="D974C531B6DED9D1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAX0</accession>
    <name>A0A1E7NAX0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">HS99_0025010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289199.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6016"/>
    <dbReference type="EnsemblBacteria" id="ARF78020">
        <property type="protein sequence ID" value="ARF78020"/>
        <property type="gene ID" value="B6264_02970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37842">
        <property type="protein sequence ID" value="OEV37842"/>
        <property type="gene ID" value="HS99_0025010"/>
    </dbReference>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="9673" checksum="EACE21F0F15FCBF7" modified="2017-01-18" version="1">MAKIAAARKDRKPRPNPLHEARITYIDYKDTNLLRKFISDRGKIRSRRVTRLTVQQQHAMARAIKNAREMALLPYGSGSQQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB07</accession>
    <name>A0A1E7NB07_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3747"/>
    <dbReference type="EnsemblBacteria" id="ARF82591">
        <property type="protein sequence ID" value="ARF82591"/>
        <property type="gene ID" value="B6264_03195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37865">
        <property type="protein sequence ID" value="OEV37865"/>
        <property type="gene ID" value="HS99_0024795"/>
    </dbReference>
    <dbReference type="OMA" id="WYPLTLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29369" checksum="5C288E0EA9D08262" modified="2017-01-18" version="1">MGLMLLYALLPLIWLFMSSTKDSASLTSGFGLWFGHGFHLFDNIGDVLSYDDGIYLRWFGNTLLYAVVGAGGAAFLSTAAGYGLAKYRFRGRTALSAVVLGAIAIPGTALAVPTYLLFSKVGIVDTPWAVLLPSLVSPFGVYLMRVYAAEAVPDSMLEAARIDGSGEVRTFFTISLRLLAPGFVTVLLFALVATWNNYFLPLIVLSNPKWFPLTVGLNQWNSLATGAAGSGATTTNFYPLVITGSLLAIVPLVVAFLFLQRFWQSGLAAGSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB33</accession>
    <name>A0A1E7NB33_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="9" type="ORF">HS99_0023775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278246.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2124"/>
    <dbReference type="EnsemblBacteria" id="ARF79447">
        <property type="protein sequence ID" value="ARF79447"/>
        <property type="gene ID" value="B6264_11445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37897">
        <property type="protein sequence ID" value="OEV37897"/>
        <property type="gene ID" value="HS99_0023775"/>
    </dbReference>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="40542" checksum="78DF42FF6B651595" modified="2017-01-18" version="1">MHVAHLSLADFRSYARAEVPLDPGVTAFVGPNGQGKTNLVEAIGYVATLGSHRVATDAPLIRLGAERAVIRTSVVDRGRSTLVELELTPGKANRARINRSDNVRPRDVLGLLRTVLFAPEDLSLVKGDPGERRRFLDELLTARAPRLAGVRQDYERVLKQRNALLKTAAMARRAGGGKGADLSTLEVWDGHLARAGAELTAFRIQLVAALQPLVTAAYGQLAPGGGETALEYRSSFEGELPTSREQAEEQLLQALQAVRKQEVERGITLVGPHRDELVLKLGPLPAKGYASHGESWSFALALRLASYELLRADGGEPVLILDDVFAELDAARRDRLAELVADGEQVLVTAAVAEDVPKALAGARFAVSDGAVRRIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB44</accession>
    <name>A0A1E7NB44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278253.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2117"/>
    <dbReference type="EnsemblBacteria" id="ARF79455">
        <property type="protein sequence ID" value="ARF79455"/>
        <property type="gene ID" value="B6264_11485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37905">
        <property type="protein sequence ID" value="OEV37905"/>
        <property type="gene ID" value="HS99_0023815"/>
    </dbReference>
    <dbReference type="OMA" id="MLDIASW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="18910" checksum="44B3B33C31BFD9B6" modified="2017-01-18" version="1">MTEGTTSAVETEAAAGADESLVARLEQEGDIAADYLEGLLDIADLDGDIDMDVEGDRALVSIVSDGNDRALQRLVGQDGEVLEALQELTRLAVHRETGERSRLMLDIAGFRARKREELAALGAEAAEQVRSTGEQVKLRPMTPFERKVVHDAVAAAGLRSESEGEEPQRCVVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB87</accession>
    <name>A0A1E7NB87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0024200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552059.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000673.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2040"/>
    <dbReference type="EnsemblBacteria" id="ARF79521">
        <property type="protein sequence ID" value="ARF79521"/>
        <property type="gene ID" value="B6264_11875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37966">
        <property type="protein sequence ID" value="OEV37966"/>
        <property type="gene ID" value="HS99_0024200"/>
    </dbReference>
    <dbReference type="OMA" id="GFWLGHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25774" checksum="C6B55F4613C944F9" modified="2017-01-18" version="1">MDYNQLAVNLLDAKSLISSLGAIGLIAIIFAETGLLVGFFFPGDSLLIIGGVAASNAASSVLGDGAKLPIAVLLTGCPVAAIAGAQLGHLIGAKVGPKMFDKPESKIFRREYVVKAEEYFNKFGSGKAVVLARFMPIIRTFLNPVAGTLEMPARTFFVWNVVGGVLWTESMLLIGYFFGDALAPVIDKYLIPAVLLIVLLSISPILVEVVRERRKKKAGLVEVPAADAMQGSGSGSGSGRHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP9</accession>
    <name>A0A1E7NBP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366704.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000966.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5939"/>
    <dbReference type="EnsemblBacteria" id="ARF79672">
        <property type="protein sequence ID" value="ARF79672"/>
        <property type="gene ID" value="B6264_12845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38119">
        <property type="protein sequence ID" value="OEV38119"/>
        <property type="gene ID" value="HS99_0023255"/>
    </dbReference>
    <dbReference type="OMA" id="GTNPVNK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="25042" checksum="F9E84B5D05D008CA" modified="2017-01-18" version="1">MNKRLLAVPALGVLLAFGAVGCGGDDNSKQLESWASNVCGAAKDPIAQAQTALADTGQVKTGESPADLQKRLSTDIGRLAKTNQDIGAAIDAAGVPKVDNGAALQKNTVDELKKASDGYLDVQKKLDALPNNDQAKFADGLHSVADRLQQLSSLSTQAQAKLQRGDLGAAMAKQEGCKPTQTTPSAGASGRAGGSPATGGASASPSAGASASAGAPSGTPAPGATDTASPAATPSAGASTTPAASATTPATPAPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBV6</accession>
    <name>A0A1E7NBV6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene472"/>
    <dbReference type="EnsemblBacteria" id="ARF78843">
        <property type="protein sequence ID" value="ARF78843"/>
        <property type="gene ID" value="B6264_07865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38172">
        <property type="protein sequence ID" value="OEV38172"/>
        <property type="gene ID" value="HS99_0023590"/>
    </dbReference>
    <dbReference type="OMA" id="MFVKYSQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="29088" checksum="12670B3B561C3438" modified="2017-01-18" version="1">MTGTGDDKHYGHGPEQVGVPRKKKAWPEKQKGPVLVRRDQVGTSTTDQRLLDTTGPTDWLHTDPWRVLRITSEFVEGFGALAELPPAVSVFGSARTPVGSPEYEAGAAIGRALAEAGYAVITGGGPGAMEAANRGASEAGGLSVGLGIELPFEQGLNEFVDLGLNFRYFFVRKTMFVKYAQGFVVLPGGLGTLDELFEALTLVQTKKVTRFPVILYGSAYWGGLYEWLKNTLVAQGKAAPHDLELFHITDEVDEVLKILAEARRPVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBZ9</accession>
    <name>A0A1E7NBZ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0021940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290044.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3313"/>
    <dbReference type="EnsemblBacteria" id="ARF80269">
        <property type="protein sequence ID" value="ARF80269"/>
        <property type="gene ID" value="B6264_16340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38221">
        <property type="protein sequence ID" value="OEV38221"/>
        <property type="gene ID" value="HS99_0021940"/>
    </dbReference>
    <dbReference type="OMA" id="FYRNMRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="686" mass="72929" checksum="2FA74C6F62DD9F36" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC04</accession>
    <name>A0A1E7NC04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556896.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3307"/>
    <dbReference type="EnsemblBacteria" id="OEV38215">
        <property type="protein sequence ID" value="OEV38215"/>
        <property type="gene ID" value="HS99_0021910"/>
    </dbReference>
    <dbReference type="OMA" id="MITARNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="21648" checksum="F9515F473F157561" modified="2017-01-18" version="1">MRIAVLLYPDFTTLDAVGPYEVLSRIPGAEVVFTAAGRGPVRNDLTSLAITADAALDEVDSADLLLVPGGPGTEAQLTDEAVLDWVRRIDATTTWTTSVCSGSLLLGAAGLLRGRRATSHWGVLDQLPRFGAEPTGSERIVVDGKYATAAGVSAGIDLALTLTGLIAGDETAQAIQLLIEYDPQPPYAAGSLAKASPEVVAGAHRLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC86</accession>
    <name>A0A1E7NC86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284109.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000579.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4207"/>
    <dbReference type="EnsemblBacteria" id="ARF80207">
        <property type="protein sequence ID" value="ARF80207"/>
        <property type="gene ID" value="B6264_15960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38274">
        <property type="protein sequence ID" value="OEV38274"/>
        <property type="gene ID" value="HS99_0022310"/>
    </dbReference>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17222" checksum="8501EECF774E9DE2" modified="2017-01-18" version="1">MTERLQPGDTAPAFSLSDADGNQVSLADHLGRKVIVYFYPAALTPGCTKQACDFTDNLEVFAGAGYDVIGISPDQPEKLGKFREKEDLKVTLLSDPDHQVLEAYAAYGEKQNYGRTYQGVIRSTIVVDEQGKVERALYNVKATGHVAKLLRDLKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC87</accession>
    <name>A0A1E7NC87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4167"/>
    <dbReference type="EnsemblBacteria" id="OEV38309">
        <property type="protein sequence ID" value="OEV38309"/>
        <property type="gene ID" value="HS99_0022515"/>
    </dbReference>
    <dbReference type="OMA" id="WQQSYGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25111" checksum="6E3C58CE874F5E41" modified="2017-01-18" version="1">MLVVEDDPFVRSALIRHLTDAGHAVRSVGTALEALREVAQVGCDLVILDLGLPDLDGSEALKMIRGLTNVPVIISTARDDEAEIVRLLNDGADDYLVKPFSGEHLSARMTAVLRRLGGGAAPVAQVLRVGGLAIDIQRREAVLDGRALDLTRREFDLLAFLAARPGVVVPRKEILAEVWRQTYGGDQTIDVHLSWLRRKLGETASNPRYLHTVRGVGVRLEAPGGPAEHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD2</accession>
    <name>A0A1E7NCD2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387067.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1749"/>
    <dbReference type="EnsemblBacteria" id="ARF82862">
        <property type="protein sequence ID" value="ARF82862"/>
        <property type="gene ID" value="B6264_16140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38350">
        <property type="protein sequence ID" value="OEV38350"/>
        <property type="gene ID" value="HS99_0022140"/>
    </dbReference>
    <dbReference type="OMA" id="ISARCVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8396" checksum="FC1C6BC22D501FE2" modified="2017-01-18" version="1">MLTGQLVTDGGALTSVAAVAAVALVAGAVAGALAGARLLGARAPAAVRSGVLRRRAFRTAFLPQRDPDARGRRRPRAPGAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCL6</accession>
    <name>A0A1E7NCL6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554522.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene318"/>
    <dbReference type="EnsemblBacteria" id="ARF82162">
        <property type="protein sequence ID" value="ARF82162"/>
        <property type="gene ID" value="B6264_27745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38446">
        <property type="protein sequence ID" value="OEV38446"/>
        <property type="gene ID" value="HS99_0021310"/>
    </dbReference>
    <dbReference type="OMA" id="KVIAFPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="21818" checksum="58F6E093F46F7A25" modified="2017-01-18" version="1">MSAFNCSKPAERAAGLREAVAAVRRGELVVLPTDTVYGIGADAFAPAAVARLLEAKGRGRNMPSPVLVGSLADLDALVDDLPQVARELVAAFWPGGLTVVARHKPSLAWDLGDTSGTVAVRMPDHPVALDLLRATGPLAVSSANLTGKPSPQDCGSAQGMLGDAVAVYLDGGPTEAAVPSSIVDVTGEVPVLVRAGAISAMRLREVAPGLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN6</accession>
    <name>A0A1E7NCN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1508 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287750.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene319"/>
    <dbReference type="EnsemblBacteria" id="ARF82161">
        <property type="protein sequence ID" value="ARF82161"/>
        <property type="gene ID" value="B6264_27735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38447">
        <property type="protein sequence ID" value="OEV38447"/>
        <property type="gene ID" value="HS99_0021315"/>
    </dbReference>
    <dbReference type="OMA" id="DESGMHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="62" mass="6822" checksum="86E7A5E26339184D" modified="2017-01-18" version="1">MAGKFELYKDESGMHRFRLKASNGSIVVTGDPQESKDDCLKSIESIRKLAPYAELKETAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU7</accession>
    <name>A0A1E7NCU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3117"/>
    <dbReference type="EnsemblBacteria" id="ARF82085">
        <property type="protein sequence ID" value="ARF82085"/>
        <property type="gene ID" value="B6264_27265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38519">
        <property type="protein sequence ID" value="OEV38519"/>
        <property type="gene ID" value="HS99_0021780"/>
    </dbReference>
    <dbReference type="OMA" id="RVRDRDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="36859" checksum="C8422B7F289E1C91" modified="2017-01-18" version="1">MVRMPATPTPSAPNGRYNRPDASMSLLTNVMDHSLDEGYAEAAAARGGEHDSRIPRTLRGLLTLGAGLALVGAVVTVGAVNAHKAEPTLAKERDALIHRINDSNGTADHLQKEVQDLRRKVEDTQQQALPSGDAGAAGLTDQVGLGEVTGPGVKLVLEDAAGTGSGGNVDPRAGQGFSNSGRLRDRDLQLVVNGLWGSGAEAVSINGQRLTALSAIRAAGEAVLVDNRPLVPPYNIQAIGDGPKLLSAFENDMAGQYLRLLEEKYGIKSTLSAQKSLTLPAAVGVTLRTAQPVTPEPSPTPTPTPSGGSSTGPGGTPSGGSGTAESPGASVSPSVTRSVPTAKRRPTSGSAKTTTGTGAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND01</accession>
    <name>A0A1E7ND01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4157"/>
    <dbReference type="EnsemblBacteria" id="ARF82855">
        <property type="protein sequence ID" value="ARF82855"/>
        <property type="gene ID" value="B6264_15705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38363">
        <property type="protein sequence ID" value="OEV38363"/>
        <property type="gene ID" value="HS99_0022565"/>
    </dbReference>
    <dbReference type="OMA" id="DYNIMYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="425" mass="46191" checksum="54FDFCB8F7D9D96F" modified="2017-01-18" version="1">MLAAGAATAATLATGCGSDRAGGGGEHKAGNAVPVAPTPGNHSATPAPAPQKPQTVLIGDGSTSDTGAQPHQPVVERLEPGQRPPQFVVFSWDGAGELDNGLFARFRRLAREHNASMTFFLSGLYLLPESKKDLYRPPQHKVGASEIGYLSDQHIHDTLENVHAAWLEGHEIGTHFNGHFCGSTGVGQWSPEEWDSEIQQAMDFVTNWRTNTGFTDLPALPFDYRKELIGSRTPCLEGQRNLLPTAVKRGWRYDSSGNGTQVWPQKIQGGALWDLPLQAIPFPGHTFQVLSMDYNIMFNQCGPNTKADPALYPGFQAQARDSYLMGFDRTYNSNRAPYIIGNHFEEWNGGIYMNAVEEALRLIAGKPEVRLVSFRQLVDWLDAQDPAVLRKLRSLGPGQSPAGGWEGFLGTPAAPPVPSPTAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND50</accession>
    <name>A0A1E7ND50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-ketoadipyl CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281146.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000383.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene598"/>
    <dbReference type="EnsemblBacteria" id="ARF77653">
        <property type="protein sequence ID" value="ARF77653"/>
        <property type="gene ID" value="B6264_00815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38622">
        <property type="protein sequence ID" value="OEV38622"/>
        <property type="gene ID" value="HS99_0020400"/>
    </dbReference>
    <dbReference type="OMA" id="NASPMND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="41599" checksum="EAF68A9AC0834280" modified="2017-01-18" version="1">MRPVYFAAARRTPIGRLRGALATVRPDDLSATVLRALLADVPALDPARIDDVYWGAANQAGEDNRNAARMAVLLAGLPETVPGATVNRLCASGLEAVTLAARAIGSGEAEVVLAGGCESMTRAPFVLPRPDEALPHRIETHDTRLGWRLTNPRMAELHGVLSMGETAEEVAGRYGIGRERQDAFALRSHQRAAAARKDGHFDAELIPVERPDGVTVTQDEGVREDTSLEKLARLKPAFRQGGTVTAGNASPMNDGAAGLVLVSEEALRDLGLQPLGRYVAGASAGVHPDVMGIGPVPATAKVLGRAGWSLADLDTAELNEAFAAQALASADGIGFSPERADEVVNPSGGAIALGHPLGGSGARILTTLLHRMRRTGARRGLATMCVGVGQGTAVLVENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD9</accession>
    <name>A0A1E7NDD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070043273.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1823"/>
    <dbReference type="EnsemblBacteria" id="OEV38695">
        <property type="protein sequence ID" value="OEV38695"/>
        <property type="gene ID" value="HS99_0020855"/>
    </dbReference>
    <dbReference type="OMA" id="YEEFCAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="33347" checksum="1C3B2C9B64C9C45E" modified="2017-01-18" version="1">MKSNKLPKVLHEVCGRSLVGHAVSAAGADFAGLAKYGLFGALGHQEYLLRAQQQLTGLYEQGLEVHLRVLEAGDFEDYCSALGLDPRAPAARVAYAGDPELAGEPFVYAGEPLVDLLPVLLDDHRARVRMSVACAALLGAVGDDPTGQRRMAAVMRYVTSVYLALAEGAGEGCHLLTLRCHGPEDGEELTSAVDVCVERGHLHPAGRDAEAFCVTLAAGVASGGEGALLLHGDPSAGNGDGPPDRSPDGPSGGPPGGPGPGPRVRGWALAGGRLRPMTAHEVFDELADDAARGLPFPPGVVPQPGFRLPDFPGAGAEAGGGGGPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE4</accession>
    <name>A0A1E7NDE4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0020030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene671"/>
    <dbReference type="EnsemblBacteria" id="OEV38701">
        <property type="protein sequence ID" value="OEV38701"/>
        <property type="gene ID" value="HS99_0020030"/>
    </dbReference>
    <dbReference type="OMA" id="LFLSEHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="35617" checksum="132A442566C12420" modified="2017-01-18" version="1">MTLRERAARTRSLPPLGGDAPGLLLAAVGVAAAIAVHAAVPAVPELTAAVVLGMAVAHLPGLRPVVRGVARPGLSTAGKRLMRLGIVLLGLKLSLDDVLGLGWATVAMVLTVVAATFAGTLWLGRRLGLPGDQSLLVATGYSICGASAIGAVSQAAGSEEEDVASSVALVTLCGTLAIAVLPLLQHPLGLGEIEFGRWVGASVHDVGQVVATAQTGGPGALREAVLVKLMRVMLLAPLVAGVAVVARRNARGAAAGGASADGADGVAKSGNRPPIVPLFVAGFLVMIVLRTTGVLPERALTLAGDAQELLLAAALFGLGSAVHLPTMVRTGGRLALLGLGSWVVVAGVSYAGVLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDQ2</accession>
    <name>A0A1E7NDQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366892.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000914.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6272"/>
    <dbReference type="EnsemblBacteria" id="ARF81224">
        <property type="protein sequence ID" value="ARF81224"/>
        <property type="gene ID" value="B6264_22060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38819">
        <property type="protein sequence ID" value="OEV38819"/>
        <property type="gene ID" value="HS99_0019325"/>
    </dbReference>
    <dbReference type="OMA" id="CRWEESA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="21236" checksum="16B815F6AE45AB6F" modified="2017-01-18" version="1">MTSQAPSDAADFLALLTGLAATADLGGLRYDASLPLLATRFGDPYDSGRVHRQTRWPHAFGWGDAWTVFCRCRRLRSFSLPTWHGELELPVDGGGLRTYGTRVTESALTAALAAAGCSWESVTYQNIPDQRTLEVAPAEEVRVGFVLVDRLDQDQPPLADWLLHKVSLWGYDHPDCPEPDRTLPDDGWGAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE41</accession>
    <name>A0A1E7NE41_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286376.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000458.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7352"/>
    <dbReference type="EnsemblBacteria" id="ARF81171">
        <property type="protein sequence ID" value="ARF81171"/>
        <property type="gene ID" value="B6264_21735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38763">
        <property type="protein sequence ID" value="OEV38763"/>
        <property type="gene ID" value="HS99_0019005"/>
    </dbReference>
    <dbReference type="OMA" id="TRCHIGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18085" checksum="ED28F666C23F24D1" modified="2017-01-18" version="1">MQITTRVECPEDAPATRRVHMAAFPGPDEADLVDALRRDPSWLPGLSLVAVDDAGLVVGHALLTRLQVGDGGGTGDALALAPVAVAPEWQRQGVGELVVRAALSAAEEAGEKLVVVLGDPGYYGRFGFIPAGRHEVTGPFEVPDAYFQVLPLAAYDGGPRGLCRYPEPFVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE71</accession>
    <name>A0A1E7NE71_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0018000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481444.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4365"/>
    <dbReference type="EnsemblBacteria" id="ARF83227">
        <property type="protein sequence ID" value="ARF83227"/>
        <property type="gene ID" value="B6264_30270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38999">
        <property type="protein sequence ID" value="OEV38999"/>
        <property type="gene ID" value="HS99_0018000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="689" mass="73426" checksum="73FE874869D03619" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH2</accession>
    <name>A0A1E7NEH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39099">
        <property type="protein sequence ID" value="OEV39099"/>
        <property type="gene ID" value="HS99_0018615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8443" checksum="0CD8B768BBFBD192" modified="2017-01-18" version="1">MALPEVGQEVLELGCVVPAVDPQVGPKLVERLGVGGEFGVSDLADEGGRVVAVDEPVRVLPGVKARGAAGDVLQGLLADAVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL3</accession>
    <name>A0A1E7NEL3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557120.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83308">
        <property type="protein sequence ID" value="ARF83308"/>
        <property type="gene ID" value="B6264_30740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39075">
        <property type="protein sequence ID" value="OEV39075"/>
        <property type="gene ID" value="HS99_0018450"/>
    </dbReference>
    <dbReference type="OMA" id="AMPTMER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16237" checksum="CF6824D8E4FBC8CA" modified="2017-01-18" version="1">MNDMFAALETLTHRGPNRRDVAADTLGDLLRGTALDTDTANLVVGRLVSLAVNEPVTKVRESALNSISEAFNHHRLPLDLVEPLAAAMPTMERELLEHTLYILGATHDPQASTLIEPFLRHPDPQVREQARLAAAAITAAEPESPTHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU7</accession>
    <name>A0A1E7NEU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550103.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3476"/>
    <dbReference type="EnsemblBacteria" id="OEV39168">
        <property type="protein sequence ID" value="OEV39168"/>
        <property type="gene ID" value="HS99_0000080"/>
    </dbReference>
    <dbReference type="OMA" id="WSRFTGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199062" evidence="1">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="48981" checksum="68AD1D6B89B1B72E" modified="2017-01-18" version="1">MKKSARALAALLVAGLSLTACGSSGDSGSGAGSGGSADAPGAQALDQASGVTTVEFWHSMTGKNADVLNGLVSQFNAAHQGRIEVKAQFQGKYDELVTKYKAAVQQKGTPALVQVYDIGTRFMIDSRQTVPAQAFADEDGYSLDDLDPNIRNYYSANGKLVSMPFNSSMPLLYLNTDAFKEAGLDPAQPPKDLNELADLAKKLTKKDADGKTVRYGFGAAVYGWFVEELIAESGTMYCDNDNGRSDKAGKVVFDSAQGAQIVQWWADLVKGGYAANTGRVTDDAQAAFKSGTVAMHLESTGVLRGYTEAAKFGVGTAPFPKVTAADQGGPAIGGASLWISGPGHSDAEKRAAWEFEKFLTGPEQQAAWHTGTGYFPVNKKSLDDPADKEWVAKYPQFQTAIDQLKATKPTPATAGCLLGVMPQARKGVETAIEQTIAGSKTAQQALSDAAKALQPAIESYNSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF38</accession>
    <name>A0A1E7NF38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000939.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3672"/>
    <dbReference type="EnsemblBacteria" id="OEV39326">
        <property type="protein sequence ID" value="OEV39326"/>
        <property type="gene ID" value="HS99_0001015"/>
    </dbReference>
    <dbReference type="OMA" id="STMSEGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="168"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="44166" checksum="6FC700FACEE086A1" modified="2017-01-18" version="1">MRFLYEDESFSFEALRAAGFANDGGADLGEVLTTLRNVGEGDEEAWLREWKRTAQRVHAIGTAALAAGHRVSAREALLRASNYYRTAEFYRRDDPAHDPEAKALSALSRETFATAAGLMDTPVEAVRIPYRDTALPGYLFLVDDSGLPRPTVVFTGGFDSTLEEAYFAIGAAALRRGYNVLAYDGPGQGAVLREQGLVFRPDWEAVVSPVIDYALSRPEIAPGRIALFGYSLGGYLAARAAAHEHRLAALVLDNGLYDYHDAHTRVMPPFLRGWIETGRDDLADPVAALLMQASTQLRWALRNGVWAFGAASSSDYIRRTAAYTLDGVAHLIECPTLVLDAEDDQFFRGQPQRVQAALTCPNTLITLPESEGAGEHCHMGAMSRFQQVAFDWLDTTLASRACAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF77</accession>
    <name>A0A1E7NF77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0000870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3640"/>
    <dbReference type="EnsemblBacteria" id="OEV39298">
        <property type="protein sequence ID" value="OEV39298"/>
        <property type="gene ID" value="HS99_0000870"/>
    </dbReference>
    <dbReference type="OMA" id="MSFNYVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199082" evidence="6">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="49817" checksum="861726528826EA63" modified="2017-01-18" version="1">MPVLVFLSAVVAVISSLGAPMIPTIATVDHVSLAEAQWSLTITMLVGAVATPVLGRLGDGPDRRRVTLAAAALVVLGSVLAALPLGFWWLIAGRALQGVGVGLTPLAIATAREALPAAASRSAVALLSITTVAGVGLGYPITGLISQSFGLHAGFWFGAVISGLALLLAALVLPEAEDRERRPLDVPGTALLSLALIGLLLALSEGESWGWGSGRLWAVAAVSLLLLAGWVRHELRTAHPLIDLRSLRNPVVLTADVAGLVAGVGMYLLISLVIRYVQTPTSTGYGLGASVVVAGLVLLPFSGASLLSSKLVPVLTRRTSSALVLPIGCAVSLGSVLFFLLSRDHLWGHLVVMGIAGLGVGCTFAVMPGLIVAAVPANEVGSAVSFNQLLRTIGYSTGSALCGAVLQAHTAPGRLLPTDSGYRDAALISCAVWVAVGLITIVLPRFSAAAAAREGARVDEELMVEESIADGVAGESEVPVVRAGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF80</accession>
    <name>A0A1E7NF80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288848.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1540"/>
    <dbReference type="EnsemblBacteria" id="OEV39366">
        <property type="protein sequence ID" value="OEV39366"/>
        <property type="gene ID" value="HS99_0001265"/>
    </dbReference>
    <dbReference type="OMA" id="HADHWEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14794" checksum="0C044BC4E97CF67A" modified="2017-01-18" version="1">MITTPIAAVDLFASALHIHPDGDVRATERRMTGGDADAWQIATFHVETDADVHADHWEMHPAAEEAVCCLAGGVRVHFRPVEPGAAEEMVRLPAGTAVVVPRGRWHRLELDAPSDLMSITLRHGTRLERRPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF85</accession>
    <name>A0A1E7NF85_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3635"/>
    <dbReference type="EnsemblBacteria" id="OEV39295">
        <property type="protein sequence ID" value="OEV39295"/>
        <property type="gene ID" value="HS99_0000850"/>
    </dbReference>
    <dbReference type="OMA" id="WYFHIAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15464" checksum="36EF28EA4E790B18" modified="2017-01-18" version="1">MQSVTDPYELRPGVPAVDVFRRLRTDAGLSDRTPEAVALGLPNTWHGVVLHHEGEPIGMGRIIGDGGTAFQIVDICVHPAHQGKGLGKRIMAALTEELDRRAPATAYVSLIADGPARVLYERFGFRDTAHHDSIGMFRPTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC6</accession>
    <name>A0A1E7NFC6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">HS99_0001530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286009.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene554"/>
    <dbReference type="EnsemblBacteria" id="OEV39409">
        <property type="protein sequence ID" value="OEV39409"/>
        <property type="gene ID" value="HS99_0001530"/>
    </dbReference>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="634" mass="67915" checksum="5B725BEBC5E68CA0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK1</accession>
    <name>A0A1E7NFK1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000418.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39415">
        <property type="protein sequence ID" value="OEV39415"/>
        <property type="gene ID" value="HS99_0001570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="8581" checksum="A9C40381986AB31D" modified="2017-01-18" version="1">MPAESTPGDIHTRDVSGTFIVGDNNHVTNTTDRPEQSQSQPRQQNSAEGQAAVFSVERGTMHVTYHAQAEPAPVPETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX2</accession>
    <name>A0A1E7NFX2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxymethylcytosylglucuronate/cytosylglucurona te synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279156.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000787.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39596">
        <property type="protein sequence ID" value="OEV39596"/>
        <property type="gene ID" value="HS99_0002670"/>
    </dbReference>
    <dbReference type="OMA" id="MNHANGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031016">
        <property type="entry name" value="CGA_synthase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04467">
        <property type="entry name" value="CGA_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42163" checksum="FA42CC281C4BB855" modified="2017-01-18" version="1">MRAKAETRTVAVAGVEFGWGSSGKLSAVLSALRGTGGHRLRFIGLASGLGRSVLAEQPVERWFDLPDRSNAELRRIVQAQRVEAALVVLDGGLAKALRACGVPVVFVDSLPFLWTDGDRPGLPLDAEVYCVQRCVELPREGARVLADVHHLRWVDAVIADGGVARGTAPTPHPRRALLNLGGLRAPQLADWADYPRLVLPPALEALTASGITEVHIAGNLPAWLAAQLVDSCAHPATTTVGALPHEDFLGRLAECDVLLTSPGLTTLLEAGQLGTPTLCLPPQNLSQIFNGRFHSQALGTDVRVRWPAAVFDEDEALALRTHGVDKALDLIHGGIARAAHLGRHRTATAVRQGLVEKLRRLSDGAGPDTPGPDWTAMTRSVGTAGAAQVADALVQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG25</accession>
    <name>A0A1E7NG25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550330.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2760"/>
    <dbReference type="EnsemblBacteria" id="OEV39624">
        <property type="protein sequence ID" value="OEV39624"/>
        <property type="gene ID" value="HS99_0002830"/>
    </dbReference>
    <dbReference type="OMA" id="EHAEMAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="35264" checksum="46EB82F90670FA38" modified="2017-01-18" version="1">MHRSTPADAPAIREPRHVPVAHVTRGGVIEGVHHGSVVVLDGDGAVRFRLGDTEAAFYPRSALKPLQAVAMVRAGLPLDGELLSLAMGSHSGEERHLAGTRRILELAGLGEDHLRNVPDLPYDPSVRDTWVRSGRPPSRLAQNCSGKHAAMLYLCRLNGWPLETYLDPAHPLQIAVAEVVQEFTGQRAAHVSVDGCGTPLFAVSLHGLARAAARIATAPPGTPGYRVADALRGHPEMASGTGRDTAALMRAVPGLLAKDGFEGVQIAALPDGRAIAVKIADGANRARIPVAAAALTLAGVDPRLLVDCAGEATSGGGRRVGSVRPVPALAPHTLTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG43</accession>
    <name>A0A1E7NG43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0002945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550355.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000682.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2783"/>
    <dbReference type="EnsemblBacteria" id="OEV39642">
        <property type="protein sequence ID" value="OEV39642"/>
        <property type="gene ID" value="HS99_0002945"/>
    </dbReference>
    <dbReference type="OMA" id="LVDDWTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040946">
        <property type="entry name" value="CBM46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18448">
        <property type="entry name" value="CBM46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199195" evidence="5">
        <location>
            <begin position="39"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="6">
        <location>
            <begin position="82"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CBM_X2" evidence="7">
        <location>
            <begin position="389"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CBM46" evidence="8">
        <location>
            <begin position="478"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="583" mass="64359" checksum="408849C4AA4AB81E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB9</accession>
    <name>A0A1E7NGB9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2916"/>
    <dbReference type="EnsemblBacteria" id="OEV39746">
        <property type="protein sequence ID" value="OEV39746"/>
        <property type="gene ID" value="HS99_0003595"/>
    </dbReference>
    <dbReference type="OMA" id="ETGMEYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="52"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="20311" checksum="4A5264A8B3D1E25D" modified="2017-01-18" version="1">MSDQVTPPFGNFPTVRRALDIRDELAPPVAEALGGWDAPEAAGAVLYVDTDPEKADTAVFCETYDAPLEYSANCVVVAAKRGGEVTMAACVVLATTRLDVNQAVRKHLGARKASFAPMDAAVEATGMEYGGITPVGLPGDWPLLIDEAVVAAPHVLVGSGRRRGKLILPGRALAALPGAEVVPGLAAVVAEPSSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD7</accession>
    <name>A0A1E7NGD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279609.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2954"/>
    <dbReference type="EnsemblBacteria" id="OEV39779">
        <property type="protein sequence ID" value="OEV39779"/>
        <property type="gene ID" value="HS99_0003785"/>
    </dbReference>
    <dbReference type="OMA" id="RANFDWM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14426" checksum="B61DADF89EACAC1D" modified="2017-01-18" version="1">MIPHRSNMDWILNDLAHSVPYVRHVIVLSADGLRIAQYGADPDTADRLAAACAGLQSLAAAVGHEFPHGNGAMKLVVIEVDGGYFYLMSAGDRAYLAVLADEGVDAGLVSHQMRDLVDRIGEHLSAPPRNPEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ0</accession>
    <name>A0A1E7NGJ0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="12" type="ORF">HS99_0003725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279581.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000683.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2942"/>
    <dbReference type="EnsemblBacteria" id="OEV39768">
        <property type="protein sequence ID" value="OEV39768"/>
        <property type="gene ID" value="HS99_0003725"/>
    </dbReference>
    <dbReference type="OMA" id="VDACRQM"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="250"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV39768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="35697" checksum="3078540001270A0A" modified="2017-01-18" version="1">MTDTPCAPDRGRGAAAVLTGLGAWLPPRRVPNSELCNRIDSSDQWIRERIGIAERRFAEPHVATGDMAVEAGARAMASAGIGAVDALVLASNTPDRPCPATAPWVAHRLGLPAVAAFDVMAGCSGFVYACTVAAGLIASGTARRVLVIGAETMTALVNPLDRATAPIFGDGAGAAVLEAGAPHAEGALGPVVWGSDGSLSDAISVPAGGARGRHRRNRTAPEEHFVHMSGNEVFRHAVRRMTAAARHAAAEAGWVLGDVDRLIAHQANQRITATVADLLEIPAARVPSNIEQVGNTAAASVPLLLAHAADQGELKPGHRVLLVAFGSGLAWAATTLVWPAGLSARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-11-11" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A0L8PC30</accession>
    <name>A0A0L8PC30_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">HS99_0025680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003956441.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A0L8PC30"/>
    <dbReference type="STRING" id="1894.JOER01000026_gene1658"/>
    <dbReference type="EnsemblBacteria" id="ARF79951">
        <property type="protein sequence ID" value="ARF79951"/>
        <property type="gene ID" value="B6264_14470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="KOG72295">
        <property type="protein sequence ID" value="KOG72295"/>
        <property type="gene ID" value="ADK78_21060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37694">
        <property type="protein sequence ID" value="OEV37694"/>
        <property type="gene ID" value="HS99_0025680"/>
    </dbReference>
    <dbReference type="GeneID" id="58435565"/>
    <dbReference type="GeneID" id="63982148"/>
    <dbReference type="GeneID" id="66955264"/>
    <dbReference type="PATRIC" id="fig|1894.11.peg.4620"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="37" mass="4389" checksum="349DC4355BFEF0C8" modified="2015-11-11" version="1">MKVKPSVKKICDKCKVIRRHGRVMVICDNLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUY2</accession>
    <name>A0A1E7MUY2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiol reductase thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000101">
        <property type="protein sequence ID" value="OEV32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291205.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000696.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000123_gene6315"/>
    <dbReference type="EnsemblBacteria" id="ARF77563">
        <property type="protein sequence ID" value="ARF77563"/>
        <property type="gene ID" value="B6264_00245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32247">
        <property type="protein sequence ID" value="OEV32247"/>
        <property type="gene ID" value="HS99_0040335"/>
    </dbReference>
    <dbReference type="OMA" id="DWCGPCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14591" checksum="31B84F9AC6B6E045" modified="2017-01-18" version="1">MTGLVVCVVVLAMATTFGLLRAGRDGRLRVRTKDGTVRLSEADLGGPLGERATLVQFSTAFCQPCRATRRVLAEVAGMVDGVEHVELDAEAQLELVRRLEVLRTPTVLVLDAAGRVVRRAAGMPRKADVIAALGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV47</accession>
    <name>A0A1E7MV47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289864.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6871"/>
    <dbReference type="EnsemblBacteria" id="OEV32295">
        <property type="protein sequence ID" value="OEV32295"/>
        <property type="gene ID" value="HS99_0016420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012861">
        <property type="entry name" value="DUF1634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07843">
        <property type="entry name" value="DUF1634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="14751" checksum="62ABA83607C6F585" modified="2017-01-18" version="1">MSDLPTEPPTELPAEPPAEETVLATTPEPEAATGPTPDALAEEARTNRLTATALLATSALALLLILAGLITALAAGERTARPVALADLTSQHGAGPLLLGLGLLALSAAPALGILVTVARWLRTGDRRHALLAALVVALLLGGALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV70</accession>
    <name>A0A1E7MV70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553801.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000184.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6920"/>
    <dbReference type="EnsemblBacteria" id="OEV32332">
        <property type="protein sequence ID" value="OEV32332"/>
        <property type="gene ID" value="HS99_0016655"/>
    </dbReference>
    <dbReference type="OMA" id="EVQDVWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="22993" checksum="AAE32F3DF95D2BF4" modified="2017-01-18" version="1">MSVDTITSRLLAEHGRTYAEEAGITLRDKPSPLYRLLVMTVLCSIRISAETAIGAARELSAAGYRTPRAMADSRWQDRVDALGRAHYVRYDESTATALGEGAQLVLDRWHGDLRRLGDEADGDPDALRELLQEVPRIGPVGADIFCREVQTVWPWLRPFFDERACAAAADLGLPHTPGGLGGLVPPDEHARLAAALVRVSLSKGATAELRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV73</accession>
    <name>A0A1E7MV73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6912"/>
    <dbReference type="EnsemblBacteria" id="OEV32324">
        <property type="protein sequence ID" value="OEV32324"/>
        <property type="gene ID" value="HS99_0016610"/>
    </dbReference>
    <dbReference type="OMA" id="YAWIRDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="229"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="583" mass="63647" checksum="6EB6481798D58884" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV83</accession>
    <name>A0A1E7MV83_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000184.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6928"/>
    <dbReference type="EnsemblBacteria" id="OEV32339">
        <property type="protein sequence ID" value="OEV32339"/>
        <property type="gene ID" value="HS99_0016695"/>
    </dbReference>
    <dbReference type="OMA" id="WHNERMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16269" checksum="BEAA024BA655A539" modified="2017-01-18" version="1">MEDFGTPADDSAADDREVFDLCDHCGRVVAAADLLSALVPDSSALHPSDPELDGRRVLTACTVEHLAELVEYYRDRPFVLEEQWAGKVCRALAEQEDAVPLSLVARMSGLSVQQAAQGVEWHNARAREWQARYGDDAAAAAADEDEDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD8</accession>
    <name>A0A1E7MVD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553887.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6995"/>
    <dbReference type="EnsemblBacteria" id="OEV32397">
        <property type="protein sequence ID" value="OEV32397"/>
        <property type="gene ID" value="HS99_0017030"/>
    </dbReference>
    <dbReference type="OMA" id="LPATRWM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="34468" checksum="D31E1795D9A04199" modified="2017-01-18" version="1">MKIVIPGGSGALGTLLDRSLTAAGHQVVVLSRRPAGPRQVGWDGRSPGAWTAEIDGSDAVVNLAGRSVNCRYTPENRRAMMDSRVHSTRAVGRAIAEARRPPAVWLQMSTATVYAHRHHAPNDELTGRIGGGEPDAPASWRYSIDIARAWEDAQAQADTPHTRRLALRTAVVLGPERGGAFDSLSWLARLGVGGPIAGGAQYGSWIHDRDFARAVEFLIEHEELSGPVNLAAPDPLPQREFMRELRAGWGMPLALPAARWMTELGAFALRSESELLLKSRRVVPTRLLEAGFAFAYPHWPQAARNLVRRLRGRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE6</accession>
    <name>A0A1E7MVE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32394">
        <property type="protein sequence ID" value="OEV32394"/>
        <property type="gene ID" value="HS99_0017015"/>
    </dbReference>
    <dbReference type="OMA" id="THIKQVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="451" mass="45040" checksum="CAA346FF60943FC0" modified="2017-01-18" version="1">MPFRPLPEALRGAGVAQHGLEQAVHGDGVAEGDQVVVGEQPQCPVHLVRAALPEGGEGFARQRLGGVPGQGAQQVDGEGRGVLDGPQRGPPEAGDGVLGPRSHRPGVPQQFAVRREGGAGLLYVGAGLGEGDRQVAQLVGEGAGLVLLGRIEGRARVRRPAEQPGGLGGVEDVDPYGPDARVPAARAAAGDQLVAAAEQPADVGGEVSRVLGVVVDEQPAVVGAQPGDGPLDLLAGRGGEGPGGVEVDGESGEGLGELSLGLGGDPPDQPVVVGPRVGVVQGEAGLADAAEAVEGGGLGDQPAAAVVRQGVGDGPQLALPADESAGGAGRQVGRRGGRLDGQRGPRGLGREDGGVRVRVGGRGRAGAAALLEGLRVGHAALGTDVRRHGHQHFAPPTPCLRLRPPTVVLVRRVVSGLPQGRDPSGPVGISRPAPAGPGRWRAARGRCCARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI5</accession>
    <name>A0A1E7MVI5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 7">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0016285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 7"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279661.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000906.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2979"/>
    <dbReference type="EnsemblBacteria" id="OEV32273">
        <property type="protein sequence ID" value="OEV32273"/>
        <property type="gene ID" value="HS99_0016285"/>
    </dbReference>
    <dbReference type="OMA" id="PANEIIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="20634" checksum="33ECFA17B69967A7" modified="2017-01-18" version="1">MRDFAQGIARFQQDVFPAKEELFTRLAVRHAPHTLFIGCSDARVVPELITGAEPGELFVIRTAGNLVPAYTPGADGVTASIEYAVAALGVRDIVVCGHSACGAMTALAHGHDLSGAPAVADWLRLADASVARTATPGDVPALVRHNVLAQLANLATHPSVARALAERTVTLRGWVFDIATGRVEDLTPDGREAVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL3</accession>
    <name>A0A1E7MVL3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1219"/>
    <dbReference type="EnsemblBacteria" id="OEV32472">
        <property type="protein sequence ID" value="OEV32472"/>
        <property type="gene ID" value="HS99_0017480"/>
    </dbReference>
    <dbReference type="OMA" id="VITHQTS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="3">
        <location>
            <begin position="118"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="251"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="35882" checksum="AA9CB1A30A6DD853" modified="2017-01-18" version="1">MQHPAATQRIGITAVGSHLPARRLTSQQLQDEITAGTRLALPERMLEKATGIRTRRFAADGEYASTLATGAARRALAARGLDPRDIDLLLFASATRDICEPATAHIVQTELGTRAHALDVSNACNSFLNGIDLARAMILAGRARRALVVTGETPSRAMRRDPADAAALRDGFAGYTFGDAGAAVVVEPVERGGILDTATVTASEHWQAGGIPGGGSRHPRGDEYSYFRGGGKELRGIFERIGPAALADLTQRTGLTWDDYARVLVHQVTVPYLERFVELTGAPADRLVLTVPELGNVASATIGIQLDLVKAQLKPGEKVLMIGLGGGVSLMTMVWEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL4</accession>
    <name>A0A1E7MVL4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32465">
        <property type="protein sequence ID" value="OEV32465"/>
        <property type="gene ID" value="HS99_0017445"/>
    </dbReference>
    <dbReference type="OMA" id="WNEIENG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="31564" checksum="6235F28C6B8295DD" modified="2017-01-18" version="1">MWNSRSSGGLTVRESRLDPSASPLKAFGAQLRRLRKAAGLTQTQLGERTQLSDSQISNLERGTRNPTLEWVRAADKVLVTGGTLELTYWSLRGSSFLPGYPEYAAKEREARVIRLFELGIIPGLVQTRGYAEALEAGAVARGGVTAEQGAERVRLLLNRQERINRDPAPLIHVILDESCLRTVVGGGGAVMSQQLAHLEMLAQRSNYVVQVAPFELGALRPFMRSMSILDLGDGASLGYTETHQRGYLENDRAIVSAWAREYDLLQVEALSQTASLAKISKARRDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL8</accession>
    <name>A0A1E7MVL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557450.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32464">
        <property type="protein sequence ID" value="OEV32464"/>
        <property type="gene ID" value="HS99_0017440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8905" checksum="6D1545E7AA3029A1" modified="2017-01-18" version="1">MPDAQNSPHSFQLHEVVRDFSCLEDGKPREGVFVEVLLGTAVLRPLGATGPEWRVAPAFLQSLNPRETAPGTCGKPRRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI1</accession>
    <name>A0A1E7MWI1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554943.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3193"/>
    <dbReference type="EnsemblBacteria" id="ARF82620">
        <property type="protein sequence ID" value="ARF82620"/>
        <property type="gene ID" value="B6264_04445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32795">
        <property type="protein sequence ID" value="OEV32795"/>
        <property type="gene ID" value="HS99_0015640"/>
    </dbReference>
    <dbReference type="OMA" id="VEYREQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="21243" checksum="23ACF03DF9C522F9" modified="2017-01-18" version="1">MAGNGQARGTAGYLFEAGMLKRAKRSGWWIAGVKDPETIAEHSFRTGVVGAVLAMMEGADPAKVALLCLFHDTQETRIGDIPHIGRRYLTATSNERVTADQVSAAHPAVVTGINAVVAEYENGESLEVVVAHDADKLECLLQAVEYREQGYQNVQPWIDSSLGNLKTDSARELAEAALTMTSLEWQKVYLGSSVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS2</accession>
    <name>A0A1E7MWS2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000080">
        <property type="protein sequence ID" value="OEV32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000116_gene4540"/>
    <dbReference type="EnsemblBacteria" id="OEV32878">
        <property type="protein sequence ID" value="OEV32878"/>
        <property type="gene ID" value="HS99_0039680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23538" checksum="B11FA0B96852D4CE" modified="2017-01-18" version="1">MPVAYVLVPPGASAKTLTAGFARYLGIPVTARMTQAQLMQAVCHTYNTAGVRLVLIDEIHRLNPRTTTGAEAADLLKDLTERIGATFVYAGIDVTTTALFTGVRGAQLAARASLVETGALPARLGNRRPFTDLVTDLENALDLQRHRPGTLPRHAPYLHQRTAGRIGSLARLIREAALTAILDGTEKITKTTLDGVRLDHQAETHPTPRPRARRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX01</accession>
    <name>A0A1E7MX01_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">HS99_0013750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279992.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5771"/>
    <dbReference type="EnsemblBacteria" id="ARF81354">
        <property type="protein sequence ID" value="ARF81354"/>
        <property type="gene ID" value="B6264_22770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32944">
        <property type="protein sequence ID" value="OEV32944"/>
        <property type="gene ID" value="HS99_0013750"/>
    </dbReference>
    <dbReference type="OMA" id="GIFDTMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22798" checksum="B8EA23E192D3D7A8" modified="2017-01-18" version="1">MKPFDAPRAEQGDTPPSAFDDHLAAQLLAQRIVLLGTQVDDVSANRVCAQLLLLSAEDPRSDIGLYINSPGGSVTAGLAIYDTMRLIPNDVSTLAMGFAASMGQFLLTVGARGKRFALPNARIMMHQPSAGIGGTAADIEIQAENLEFTKRSIERITAEHTGQSEETIRRDGDRDRWFTAEQAVEYGLVDRVVESVADIRPATSRRRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXF3</accession>
    <name>A0A1E7MXF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6555"/>
    <dbReference type="EnsemblBacteria" id="ARF81323">
        <property type="protein sequence ID" value="ARF81323"/>
        <property type="gene ID" value="B6264_22610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32913">
        <property type="protein sequence ID" value="OEV32913"/>
        <property type="gene ID" value="HS99_0013595"/>
    </dbReference>
    <dbReference type="OMA" id="AGRMDYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10752" checksum="5C6AEA39F85320FB" modified="2017-01-18" version="1">MEVLCPLCRVPADRESLGCPSCREDLGVLFRLRYSARIDYNRALEALAAGDGALALGLLHRAVAAEPGLEPARELLESLSVSGPAGSASGSAPMASERDTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ1</accession>
    <name>A0A1E7MXQ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279854.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5688"/>
    <dbReference type="EnsemblBacteria" id="ARF81430">
        <property type="protein sequence ID" value="ARF81430"/>
        <property type="gene ID" value="B6264_23190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33013">
        <property type="protein sequence ID" value="OEV33013"/>
        <property type="gene ID" value="HS99_0014160"/>
    </dbReference>
    <dbReference type="OMA" id="GKLCGRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13217" checksum="6AD37E493138DE92" modified="2017-01-18" version="1">MGAVASGSFELTAFEPVETEEHEGASFGRVRIAKTFTGGLNGRSEVRMLSVGGASGGPASYVAVEHVTGELDGRAGSFVLQHAAWDTTGVTIRVVPGTGAGGLAGITGEFRLAVDESGTHTYVLEYELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS7</accession>
    <name>A0A1E7MXS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279787.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5653"/>
    <dbReference type="EnsemblBacteria" id="ARF81457">
        <property type="protein sequence ID" value="ARF81457"/>
        <property type="gene ID" value="B6264_23365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33043">
        <property type="protein sequence ID" value="OEV33043"/>
        <property type="gene ID" value="HS99_0014335"/>
    </dbReference>
    <dbReference type="OMA" id="AGDENYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15855" checksum="D1188411D8EF8688" modified="2017-01-18" version="1">MEDLDQRIVQLLLEDGRMSYTDLGKATGLSTSAVHQRVRRLEQRGVIRGYTAIIDPDAVNLALTAFISVKPFDPSAPDDTPDRLSGLPEIEACHSVAGDENYILKVRVGAPGDLEDLLARIRSAAGVSTRTTVVLSTPYEARPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ0</accession>
    <name>A0A1E7MXZ0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33289">
        <property type="protein sequence ID" value="OEV33289"/>
        <property type="gene ID" value="HS99_0038895"/>
    </dbReference>
    <dbReference type="OMA" id="AKEHERG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="620"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119635" checksum="D97788011D2D2B6D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY93</accession>
    <name>A0A1E7MY93_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287560.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3969"/>
    <dbReference type="EnsemblBacteria" id="ARF80519">
        <property type="protein sequence ID" value="ARF80519"/>
        <property type="gene ID" value="B6264_17830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33415">
        <property type="protein sequence ID" value="OEV33415"/>
        <property type="gene ID" value="HS99_0012605"/>
    </dbReference>
    <dbReference type="OMA" id="VTHTWDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20479" checksum="3C712A7780B86774" modified="2017-01-18" version="1">MSAVQDARPQYLTALAQLDRLFATITPADLDRPTPCEEYTLRQLLNHVIGGIHRFAYMGEGGHAQDVVAAIEDPSDDGWTAVLDRARARVTAAWADDSKLGRPTVAPWGEVPGAVAVGGYVMELGTHCWDIATALDNGFVLDDEVAGTALAVAQLILPPESRVEGVPFGAVRPAAEDADVHTRLAAWLGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI8</accession>
    <name>A0A1E7MYI8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282523.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5180"/>
    <dbReference type="EnsemblBacteria" id="ARF80609">
        <property type="protein sequence ID" value="ARF80609"/>
        <property type="gene ID" value="B6264_18380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33505">
        <property type="protein sequence ID" value="OEV33505"/>
        <property type="gene ID" value="HS99_0013160"/>
    </dbReference>
    <dbReference type="OMA" id="FYHDHIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="14113" checksum="801FF4CF69EE4043" modified="2017-01-18" version="1">MAGERDLATLLRGMRPQLNPGRYVYCTLPAKVPAGMRPVVTVAEPEGVTMVVTQEEADALGLRYEYVAAWITLQIHSALEAVGLTAAVAGRLAEEGISCNVVAGFHHDHLFVAADDAERAVRALEELSARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP0</accession>
    <name>A0A1E7MYP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597153.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5220"/>
    <dbReference type="EnsemblBacteria" id="ARF80642">
        <property type="protein sequence ID" value="ARF80642"/>
        <property type="gene ID" value="B6264_18580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33539">
        <property type="protein sequence ID" value="OEV33539"/>
        <property type="gene ID" value="HS99_0013360"/>
    </dbReference>
    <dbReference type="OMA" id="GTTGWIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="541" mass="58017" checksum="017DD98EEBD74CB9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV6</accession>
    <name>A0A1E7MYV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0012980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6621"/>
    <dbReference type="EnsemblBacteria" id="OEV33601">
        <property type="protein sequence ID" value="OEV33601"/>
        <property type="gene ID" value="HS99_0012980"/>
    </dbReference>
    <dbReference type="OMA" id="GWGERTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198669" evidence="6">
        <location>
            <begin position="29"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="42"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="573" mass="59776" checksum="C614E84D16FC8CD0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX4</accession>
    <name>A0A1E7MYX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386256.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000283.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33632">
        <property type="protein sequence ID" value="OEV33632"/>
        <property type="gene ID" value="HS99_0038715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="45781" checksum="2BA92C240D149D83" modified="2017-01-18" version="1">MVRSEMGGTARGAGRSGAQHAMAVNETVLAFVLGGSAPGAAGGVGTVRSWSTETEFLLPGGRRKVRPDGVWQAPEIGVPVLMVEVDRVTMAPADVAAKFPRYRELFRTRVRDNDPALADREPADRTVHWWRRTWPGHTRAGYPPVALVVTDAGPVALANRQEAVGELSAECWRGRWCREVRDDNDDGWREYDDAVPIVATTLELLAARGPLGPIWWRFGRSGRHCLIEALEDPNNRAAYDLRQAAREDEEHKAHQELMDSLVCIDCGDVPEEESTWEYGRQGQVEWTRRPGGRCWPCHQDREERLEREAEEQLEAARTANALLRPCWTCRGSIGGKEGSKLELREKASPDRLECPQCEQDRAIKDLGALVLPAPTKREQVAALVSAPDDPWWEERVLHAKLYPVRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYY0</accession>
    <name>A0A1E7MYY0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1104"/>
    <dbReference type="EnsemblBacteria" id="OEV33634">
        <property type="protein sequence ID" value="OEV33634"/>
        <property type="gene ID" value="HS99_0038510"/>
    </dbReference>
    <dbReference type="OMA" id="TGMAMPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="451" mass="47819" checksum="1C0D02F1C33AABDB" modified="2017-01-18" version="1">MTRSAARPNRPVPSRRTTELVLVLAAVLTAVFGYVEVGVNLDGEVPADAARYGAEFGVLALAAHGVVRWRARYADPLLLPIAVLLNGIGLVVIHRLDRATPGREAASAQLLWSSLGVALFIAVLLLVRDHRRLRRYAYLGALVALVLLVVPVLFPPVYGSRIWIVVGPLSFQPGEFAKLLLAVFFAAYLAVHRDALALTGRRVWRWHLPRGRVLGPVLMIWAAFVGVLVLETDLGMSLLYFGLFVVMLYVATARTGWIAIGLGLAAVAAVTVGRLSPHVHSRVVDWLDPLGSIAAGRGANQIAQSLFAFAWGGELGTGLGNGHSVLIGFAAKSDFILATIGEELGLTGLVAVFLLYAVLVSRGFRTGIALRDPFGRLLAIGLAATVGLQVFVVAGGVLALIPLTGMTMPFIAQGGSSVVSNWIVVALLVRMSDDARRPAPAPFPAPGPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ30</accession>
    <name>A0A1E7MZ30_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551976.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1943"/>
    <dbReference type="EnsemblBacteria" id="ARF79606">
        <property type="protein sequence ID" value="ARF79606"/>
        <property type="gene ID" value="B6264_12385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33705">
        <property type="protein sequence ID" value="OEV33705"/>
        <property type="gene ID" value="HS99_0038130"/>
    </dbReference>
    <dbReference type="OMA" id="FIGAPPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="39916" checksum="1C6518EF1407FB72" modified="2017-01-18" version="1">MLATIATVSAAALAAPVAGLLGYRQLKRAAFAGKLRITAPAGIEESGFVRIGGIDQWVSIRGEDRRNPVVLEILGGPGASNLVFLPRTRAWEKHFTIVRWDMRGAGFTFAAGGPQGQGELTHQQLYRDALEVTEHLRARLGVDRLLLVANSFGTVLGLRLARNHPELYSGYVGTDQNIIDGGRERTAYDALLARLRAAGRKKEKELAAAVAMGADRSKWTTRDVAEYNKLVLTSDPLSYDTMKTVVMRSLWFSPLHTLRGLRSYLKAMEFSERLQLEAAALDERAEGTDFRIPFFVFQGDSDVLTPPAPARRFFDDVTAPVKEFALIRDASHFASFRHPDRFLDLMLTHVRPAVTAQPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ94</accession>
    <name>A0A1E7MZ94_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="14" type="ORF">HS99_0038000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554881.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7707"/>
    <dbReference type="EnsemblBacteria" id="ARF78573">
        <property type="protein sequence ID" value="ARF78573"/>
        <property type="gene ID" value="B6264_06275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33739">
        <property type="protein sequence ID" value="OEV33739"/>
        <property type="gene ID" value="HS99_0038000"/>
    </dbReference>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="34853" checksum="120B6E51E05ED225" modified="2017-01-18" version="1">MTRCAVMGTGSWGTAFAMVLADAGCEVVLWARRQELVDAVNSTHENPDYLPGVRLPDAVRATTDAAEALAGADFAVLVVPSQTLRDNLAAWAPLIEPQTVLVSLMKGIELGTAKRMSEVIDEVTRVGPERVAVVSGPNLAKEIANRQPAASVVACTDESVAKRLQAACHTPYFRPYTNTDVVGCELGGAVKNVIGLAVGMAAGMGLGDNTKATLITRGLAETTRLGEVLGADPHTFAGLAGMGDLVATCSSPLSRNNTFGMNLGRGMSLAETIAATRQTAEGVKSCESVLDLARRSGVDMPIVEAVVDVVHNGRPTQEALQALMSRSAKAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB0</accession>
    <name>A0A1E7MZB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553330.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3785"/>
    <dbReference type="EnsemblBacteria" id="ARF78389">
        <property type="protein sequence ID" value="ARF78389"/>
        <property type="gene ID" value="B6264_05165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33764">
        <property type="protein sequence ID" value="OEV33764"/>
        <property type="gene ID" value="HS99_0037770"/>
    </dbReference>
    <dbReference type="OMA" id="DPGFAMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="23728" checksum="7387FDFBD713BD8C" modified="2017-01-18" version="1">MTVTARLALTDTGEGADLSAFLLRLLRFDKAAAVRLQAVGPAGEDGVLAVFGRLPLGGSGALAVRTARLDGLDEPVDLTVSAGQLLDGVDAEAGVVELPAPVTGPAWAGLLPPRAGWRPVGAPPVAEVYPELMAGVREFRERSEAVPAHHRTRAVLDQLADEIWSRPVGVLPELPLRAVHAAYVIGFLKPGAPLSVHRAGGWLRLSAPAGSVVVRTAAAPGAGLGLSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC9</accession>
    <name>A0A1E7MZC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557994.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4526"/>
    <dbReference type="EnsemblBacteria" id="ARF80384">
        <property type="protein sequence ID" value="ARF80384"/>
        <property type="gene ID" value="B6264_17030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33805">
        <property type="protein sequence ID" value="OEV33805"/>
        <property type="gene ID" value="HS99_0037655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="12434" checksum="9B1C70BFBAFAEA30" modified="2017-01-18" version="1">MRYPVALALTLLTETPVYAAALTRIGRVHPGRAAAAGVLVNLVTHPLLWWTLRHWTDGPAAAYWTGFALSETAVCAVEALLLCPVAGLRPRDPLPWIASGTANAVSLLAGTVVGLLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N086</accession>
    <name>A0A1E7N086_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0011625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289960.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000594.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2336"/>
    <dbReference type="EnsemblBacteria" id="ARF77940">
        <property type="protein sequence ID" value="ARF77940"/>
        <property type="gene ID" value="B6264_02480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34081">
        <property type="protein sequence ID" value="OEV34081"/>
        <property type="gene ID" value="HS99_0011625"/>
    </dbReference>
    <dbReference type="OMA" id="SDLWYDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="480" mass="52675" checksum="3C9C9FB7D40FD0CF" modified="2017-01-18" version="1">MTVNDDVFTDWKNREEIAESMIPIIGRLHREKDVTVLLHSRSLVNKSVVSILKTHRFARQIAGEELSVTETMPFLQALTTLDLGPSQIDLGMLASTYRADDHGLSVEEFTARAVAGATGENKLERRSAQDVVLYGFGRIGRLVARLLIEKASGNGLRLKAIVVRNGGGDDLVKRASLLRRDSIHGQFQGTITVDEANNKIVVNGNEITVIYSNDPSEVDYTEYGIKDAILIDNTGKWRDREGLSKHLRPGIAKVVLTAPGKGDVPNIVHGVNHDMIKPDEQIISCASCTTNAIVPPLKAMEDEYGVVRGHVETVHSFTNDQNLLDNYHKADRRGRSAPLNMVITETGAASAVAKALPDLKAKITGSSIRVPVPDVSIAILNLQLKREADREEVLDYLRNISLTSPLKRQIDFIDSPDAVSSDFIGSRHASIVDAGATKVDGDNAILYLWYDNEFGYSCQVVRVVQYISGVEYPTFPVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S8</accession>
    <name>A0A1E7N0S8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2599"/>
    <dbReference type="EnsemblBacteria" id="OEV34284">
        <property type="protein sequence ID" value="OEV34284"/>
        <property type="gene ID" value="HS99_0036695"/>
    </dbReference>
    <dbReference type="OMA" id="WRTESTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="27700" checksum="6703E547148A02F2" modified="2017-01-18" version="1">MARWTPWHRDAEPDGGSGSVRVYCLPHAGGSASAYLPWARDTGQPDLTVVPVELPGRGTRLAEPPAAGMDEVVDGVLAVLASRPADEPFILLGHSMGSRIVYETTRRLAADGRPLPLSLVVSGGRAPGTPDVAQLHDLTDDDLLERLVELGGTPAEVLEFQDLMRMVLPVLRADVTLLAEYNERIRPTVLPCPVLALGGSDDLMAGPEWITGWRCTTAARFRHRILPGDHFFLHQQRSEVLAELAAEARAGLEAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U8</accession>
    <name>A0A1E7N0U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7646"/>
    <dbReference type="EnsemblBacteria" id="ARF78482">
        <property type="protein sequence ID" value="ARF78482"/>
        <property type="gene ID" value="B6264_05740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34306">
        <property type="protein sequence ID" value="OEV34306"/>
        <property type="gene ID" value="HS99_0036640"/>
    </dbReference>
    <dbReference type="OMA" id="DRLAHKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9425" checksum="551AF978AE7514E0" modified="2017-01-18" version="1">MGLMDNLKGKAEELKEKAGELAGRHSDQIEQIVDRAGGAIDKATKGKYSERIEHGAGRAKDAVEDFAHKPKPGGEQGRAPQPPQAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N175</accession>
    <name>A0A1E7N175_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552296.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1063"/>
    <dbReference type="EnsemblBacteria" id="ARF78951">
        <property type="protein sequence ID" value="ARF78951"/>
        <property type="gene ID" value="B6264_08490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34450">
        <property type="protein sequence ID" value="OEV34450"/>
        <property type="gene ID" value="HS99_0035705"/>
    </dbReference>
    <dbReference type="OMA" id="REHGERW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="47777" checksum="E2834EBB0ABD27B9" modified="2017-01-18" version="1">MSDAVPQYGFTQARRGYAPEQVDRALVALTAQRDEAWERLSVLGAGIRQMETRLEAIRRAADEAPEPDYQVLSEQAAGLAEMAVNEARAVREKAERFAEDLRDEVYEQGQALAEAAKEYAATTRAEADAAARRTEERTRAEAEAIRAEADRESRAARDGATAYAAKVRVAAAEAGEQAEAELAAKRRRADEAFAAALAKADAEEAEFSATAERRVKEAEQHRETVLNQIKQLETDAQAKADQLIENARREAERINAESEREQREFEARLETVQQHLDHIKATLASLTGAAVGQVEPGALAAAGAAAAPVPVDAVADAEPVDSEADTGEIPAPDLPKAVPADGGADARAEERTTAVRRPVLGGSSAVSALPRAAAPGGAQDTEVVTGPVAPVAVPPKPAVPPLPAAEGDGAAGAAEADGADGADGVEETRIIPKIIIVDDGAGYAAPNTVTYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H6</accession>
    <name>A0A1E7N1H6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552817.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5579"/>
    <dbReference type="EnsemblBacteria" id="ARF79337">
        <property type="protein sequence ID" value="ARF79337"/>
        <property type="gene ID" value="B6264_10765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34549">
        <property type="protein sequence ID" value="OEV34549"/>
        <property type="gene ID" value="HS99_0035245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9669" checksum="B9D1C3067D65C9FE" modified="2017-01-18" version="1">MNTDHARTLELIRSAEAATLRALSGEGAAAGEAHRLTAEAARLLEPITEAGPCQRKGCTNTVMQRATGRPRLYCGAVCQQAAYWARKADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1R1</accession>
    <name>A0A1E7N1R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558422.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000134_gene568"/>
    <dbReference type="EnsemblBacteria" id="ARF82030">
        <property type="protein sequence ID" value="ARF82030"/>
        <property type="gene ID" value="B6264_26910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34605">
        <property type="protein sequence ID" value="OEV34605"/>
        <property type="gene ID" value="HS99_0008880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22915" checksum="206FB2B051788BBB" modified="2017-01-18" version="1">MKRLGWVAAVLATAAAVSGCGGGGGQGMTGPGQAGQQVAREDADQLRPYRLTLPESLGHGRYARSHDAAPVDPRLAQVMADQIEGATAVFGWYQSAPKDRDGALAIGVTGLYGTVRSPATALEQFQSVLDGRDNVQGFIVGPRSITPPRSREPLRCRIVLVRTGGVDFRRAECSWADASAVVVVSEPLREAVRPESVDLDALAAEVAAVREDVRAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1T1</accession>
    <name>A0A1E7N1T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction endonuclease subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554742.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000470.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4273"/>
    <dbReference type="EnsemblBacteria" id="ARF82010">
        <property type="protein sequence ID" value="ARF82010"/>
        <property type="gene ID" value="B6264_26790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34625">
        <property type="protein sequence ID" value="OEV34625"/>
        <property type="gene ID" value="HS99_0009005"/>
    </dbReference>
    <dbReference type="OMA" id="RTWEHSD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="22060" checksum="8D3E846B8008E274" modified="2017-01-18" version="1">MIDEFAKGNLHGRLRRDREALLWKLDGLSEYDARRPLTATGTNLLGLVKHVATVEARYFGEVFDRPSPEPLPRWQDSDGSDLWATEDETRDQIIGFYRRTWEHSDATINELPLDAPGHVPWWPEPYSNTNLFAIMVHVLGESNRHAGHADILREGLDGRTGMRPEHEKKIDEEARAAYRAKIEQAARAAAPIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N240</accession>
    <name>A0A1E7N240_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555839.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4602"/>
    <dbReference type="EnsemblBacteria" id="ARF81882">
        <property type="protein sequence ID" value="ARF81882"/>
        <property type="gene ID" value="B6264_26020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34754">
        <property type="protein sequence ID" value="OEV34754"/>
        <property type="gene ID" value="HS99_0009740"/>
    </dbReference>
    <dbReference type="OMA" id="WHSTPAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="25930" checksum="80015DDA872211E4" modified="2017-01-18" version="1">MATRDSTDSPRRRIVEAAVELLENGGPDAVSTRAVAAAAGMQPPAIYRLFGDKDGLLEAVAEHGYAQFLERKRTQLDPDPQDPVEELRRGWDMVVEFGVSRPELFAVMNRATGRGSDVAHRAGLEILHGRVRRLAAGGWLRVDEELAAQIIQATGQGAVITWHSTPADRRNPALLTVLRESMVAAVTRAEPAVPAAESGPAAAARALCAALPDDADVLSDAEQRLLREWLTRLAADGGAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N296</accession>
    <name>A0A1E7N296_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81823">
        <property type="protein sequence ID" value="ARF81823"/>
        <property type="gene ID" value="B6264_25625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34818">
        <property type="protein sequence ID" value="OEV34818"/>
        <property type="gene ID" value="HS99_0010120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="9195" checksum="B2E3B10D7264BCD9" modified="2017-01-18" version="1">MLRTGSAPDVTCVTVSRAEDCDGWPPRPPWRRRSARPLQFSTRRDPAVIAAFVRTRVLEPEREDFRRGPDELPAHRGVAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B6</accession>
    <name>A0A1E7N2B6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0010215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7629"/>
    <dbReference type="EnsemblBacteria" id="OEV34834">
        <property type="protein sequence ID" value="OEV34834"/>
        <property type="gene ID" value="HS99_0010215"/>
    </dbReference>
    <dbReference type="OMA" id="MTAVCYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="521"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="859" mass="90273" checksum="F1F8BD784A7A1494" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N371</accession>
    <name>A0A1E7N371_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286654.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene410"/>
    <dbReference type="EnsemblBacteria" id="ARF82697">
        <property type="protein sequence ID" value="ARF82697"/>
        <property type="gene ID" value="B6264_08170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35124">
        <property type="protein sequence ID" value="OEV35124"/>
        <property type="gene ID" value="HS99_0034080"/>
    </dbReference>
    <dbReference type="OMA" id="TGKPACS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24795" checksum="3BD352B30CB7DF10" modified="2017-01-18" version="1">MRRRRAARALQAVAFDTIGAGYGEAFPAKDGQLECGRRLLAALEPGARVLDVGCGTGEPTLPQLIAGGLRVTAVDLSDVMLTLARQSRSTGPIPAEFHRIDLYDLATERADRVWGAPSLGPAGHGSFAAVTAFFSLILLPQDEIPTVLGRLRELLRPGGLLALGMVEADLDHVPLPFLGTELRISGYLREDLERVLVAAGFAVEECSGHPYAPASTTLPPEEQLFLCCRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3C0</accession>
    <name>A0A1E7N3C0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285446.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000463.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4468"/>
    <dbReference type="EnsemblBacteria" id="ARF78433">
        <property type="protein sequence ID" value="ARF78433"/>
        <property type="gene ID" value="B6264_05420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35164">
        <property type="protein sequence ID" value="OEV35164"/>
        <property type="gene ID" value="HS99_0033835"/>
    </dbReference>
    <dbReference type="OMA" id="CEADHGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21006" checksum="FB790CD3528F6907" modified="2017-01-18" version="1">MAKTGTTTTQDLRSAIERSGYYPALVSEAVESAVGPEPISSYLVHQETTFDSNEVRRHVTVLVLTPTRFVVSHTDEQSGDAGSPAVPFATTSTESVRLDRIGSVVLSRMVANPETYTPGTLPREVVLTIGWGAVQRLDLEPAGCSDPNCDADHGYTGSATADDLSLRVSEAGDGPETVAQALVFARALSDATIDNGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J0</accession>
    <name>A0A1E7N3J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1358"/>
    <dbReference type="EnsemblBacteria" id="OEV35256">
        <property type="protein sequence ID" value="OEV35256"/>
        <property type="gene ID" value="HS99_0033460"/>
    </dbReference>
    <dbReference type="OMA" id="TNIEYMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="459" mass="47196" checksum="167D0B0A6EBE166E" modified="2017-01-18" version="1">MRSTVPAGTATGDTRHVTEPALPTTVCATVPAARTMPTRATDQGSETTPPDTIRIQHALDTCAQTGQQTVAVRLQATDSGHNAFLTGPLAVHRGEVLLLDSGVTLYGSRNPADYQISGKPRCGTLASSGGGCKPLISVAGANAGIEAVRAADGSQGRIDGRGDQTVLGTTTSWWQLATDAQKAGSNQNNPRLIQADDSDNFTLYHVDLLSSPNFHVVYNGGNGFTAWGVRIKTPAGARNTDGIDPAGATNVTITDSFIMDGDDGIAIKGGNRSSSNITVTNNHFYGTHGISIGSETTSGVTNVLFRDNTLTGTDALGTTSGSSTGIRIKSSPANGGRVTGVTYLNTCLDAVRAPLVFDTHYSGGSGPNAPWFTGITVDGVTATHSPSGAKSTLVGLDRTRPLELTLQHVNLDVTTATAANARITATDTNLHPSGPDVTLTTTNGPGAAPTCTFPAFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3N6</accession>
    <name>A0A1E7N3N6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386459.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5311"/>
    <dbReference type="EnsemblBacteria" id="ARF80722">
        <property type="protein sequence ID" value="ARF80722"/>
        <property type="gene ID" value="B6264_19030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35297">
        <property type="protein sequence ID" value="OEV35297"/>
        <property type="gene ID" value="HS99_0033090"/>
    </dbReference>
    <dbReference type="OMA" id="APRFFRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26781" checksum="616FB5AAB81875F0" modified="2017-01-18" version="1">MTTAPIAPPPGGPRRLRLLSYNIRSLRDDRRALVRVIRACAPDLVCVQEAPRYWRPEGRAAWLARSTGTVVLSGGGRTAAGPLLLGRPGAVEVLGRYDRLLPKTRGLHARGFATALLRVPGAAPFTVTSCHLSLDAEERHGQFELLLDQLAIAEQGVVAGDFNEHPDGPGWRLLASQMWDGYPTAPWGGEFTSVPENPYQRIDAVFATPGTTVLGCGVPHGLPGVTEADLRAATDHLPVLAVVELPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R3</accession>
    <name>A0A1E7N3R3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282854.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5329"/>
    <dbReference type="EnsemblBacteria" id="OEV35312">
        <property type="protein sequence ID" value="OEV35312"/>
        <property type="gene ID" value="HS99_0033180"/>
    </dbReference>
    <dbReference type="OMA" id="LELFQNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="368" mass="39147" checksum="1331DE773AF20CAE" modified="2017-01-18" version="1">MTSSSNRPANPIDVEDVRTRVNAALAAFMDGQSALLGKISPQLVPAADALRDFLLDGGKRLRPAFCYWGWRAAGGAAGGEGIANAAAALELLQASALVHDDLMDRSDTRRGLPSVHRRFEALHRDSGWRGDREQYGASAAVLLGDLLLIWCDELFLRSGLDPAAVLAAKPVFDLMRTEVMLGQYLDVLEPVAGDSADEGALERARTVLHYKSAKYTIERPLQVGALLAGAGPELVEALGAFGLPLGEAFQLRDDLLGVFGDPAVTGKPAGDDLREGKRTLLVAHAMRSLPQADARHLDARLGAPDLAAEEVAELRGLVARSGAPELVEQRIEELMGQSLAALAAAPLADERARTVLLALAEAATVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N445</accession>
    <name>A0A1E7N445_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598029.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35455">
        <property type="protein sequence ID" value="OEV35455"/>
        <property type="gene ID" value="HS99_0032365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="6578" checksum="C0E5FC1A6DD4F33E" modified="2017-01-18" version="1">MTNSMRNLSAGELARRFVGRIALGFSGLALIAGAIMVALPGDTGWGGLPVASSVTTAQVTADDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J6</accession>
    <name>A0A1E7N4J6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000518.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene967"/>
    <dbReference type="EnsemblBacteria" id="ARF80812">
        <property type="protein sequence ID" value="ARF80812"/>
        <property type="gene ID" value="B6264_19560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35616">
        <property type="protein sequence ID" value="OEV35616"/>
        <property type="gene ID" value="HS99_0006790"/>
    </dbReference>
    <dbReference type="OMA" id="DEIIMMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20708" checksum="98A9CF0352C69067" modified="2017-01-18" version="1">MSEFQIPDRHAQLLEYAQSLTPPAGWKLEISGDEIIMMAGPSAIPQRNLLQIREQFDAHRPSDMMPSENSDLASPNVGKLRNPDLTYIPLESSGNQIPAEQALIAVEIVSPSNPENDLVGKVRDYPLMGIPLYLLIDPREGDITLYSEPSAGGYHQQWHGKFGDRVPVPAPFDFELVTDRLVRYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q2</accession>
    <name>A0A1E7N4Q2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0007090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551148.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene908"/>
    <dbReference type="EnsemblBacteria" id="OEV35669">
        <property type="protein sequence ID" value="OEV35669"/>
        <property type="gene ID" value="HS99_0007090"/>
    </dbReference>
    <dbReference type="OMA" id="FTPMLFM"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="13">
        <location>
            <begin position="98"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="376"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="576" mass="63000" checksum="99B623D4C3F6A7CC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C9</accession>
    <name>A0A1E7N5C9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitosanase</fullName>
            <ecNumber evidence="1">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7286"/>
    <dbReference type="EnsemblBacteria" id="ARF81117">
        <property type="protein sequence ID" value="ARF81117"/>
        <property type="gene ID" value="B6264_21365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35906">
        <property type="protein sequence ID" value="OEV35906"/>
        <property type="gene ID" value="HS99_0008590"/>
    </dbReference>
    <dbReference type="OMA" id="AQNDERD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00978">
        <property type="entry name" value="chitosanase_GH46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.386.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000400">
        <property type="entry name" value="Glyco_hydro_46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023099">
        <property type="entry name" value="Glyco_hydro_46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01374">
        <property type="entry name" value="Glyco_hydro_46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036551">
        <property type="entry name" value="Chitosanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60000">
        <property type="entry name" value="CHITOSANASE_46_80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="29797" checksum="F99CF36717319E7C" modified="2017-01-18" version="1">MRPQPRRALRIALAAALVAAPLTVAATSAAQAAPEAAASVRLKGAGLDDPHKKDIAMQLVSSAENSSLDWKAQYKYIEDIGDGRGYTAGIIGFCSGTGDMLELVQHYTDLNPGNVLAKYLPALKKVNGSDSHAGLGTAFTKDWAAAAKDPAFQQAQNDERDRVYFNPAVNQAKADGLRALGQFAYYDAIVMHGPGDSSDSFGGIRAAAMKKARTPAQGGDEATYLKAFLAARKVAMKKEAAHSDTSRVDTEQLVFLNAGNFDLNPPLKWKVYGDSYSIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E6</accession>
    <name>A0A1E7N5E6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">HS99_0008550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030055649.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7278"/>
    <dbReference type="EnsemblBacteria" id="ARF81109">
        <property type="protein sequence ID" value="ARF81109"/>
        <property type="gene ID" value="B6264_21325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35898">
        <property type="protein sequence ID" value="OEV35898"/>
        <property type="gene ID" value="HS99_0008550"/>
    </dbReference>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14675" checksum="B6E6F9687BEBE074" modified="2017-01-18" version="1">MARVKRAVNAHKKRRVILERASGYRGQRSRLYRKAKEQVTHSLVYNFNDRKKRKGDFRQLWIQRINAAARANGITYNRFVQGLKAASVEIDRKMLADLAVNDPGAFASLVEVAQKALPADVNAPKAAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F0</accession>
    <name>A0A1E7N5F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286281.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7304"/>
    <dbReference type="EnsemblBacteria" id="ARF81133">
        <property type="protein sequence ID" value="ARF81133"/>
        <property type="gene ID" value="B6264_21455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35921">
        <property type="protein sequence ID" value="OEV35921"/>
        <property type="gene ID" value="HS99_0008680"/>
    </dbReference>
    <dbReference type="OMA" id="YRIDPLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18516" checksum="8247ACC48B777210" modified="2017-01-18" version="1">MGMSVIISAAAAEDAEQILKLQYLGYQPEAELYGDWAIEPLTQSLESLRTELTEQHVLVARLGDEVVGVVRGHVDAEGIGRIGRLVVHPRMQRHGLGGRLLEALERRMAEDSRPVTAYRLFTGHRSLGNLRLYARQGYRQTSVEQVSSRLSFVHLEKPVASELAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F5</accession>
    <name>A0A1E7N5F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0008685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7305"/>
    <dbReference type="EnsemblBacteria" id="ARF81134">
        <property type="protein sequence ID" value="ARF81134"/>
        <property type="gene ID" value="B6264_21460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35922">
        <property type="protein sequence ID" value="OEV35922"/>
        <property type="gene ID" value="HS99_0008685"/>
    </dbReference>
    <dbReference type="OMA" id="VIRKICH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="36596" checksum="FB3064FA8F904714" modified="2017-01-18" version="1">MITTTDLTKVYRSRGREVTALAGVDLHVRPGEVYGVVGTSGAGKSTLIRCVNMLERPTSGTVTVDGVELTALSGGENRAGKDLREARRRIGMVFQHFNLLSSRTVQQNVELPLEIIGLDRTQRRRKAAELLDLVGLGDKARSYPNQLSGGQKQRVGIARALAGDPKVLLSDEATSALDPETTRSILKLLRDLNQQLGLTVLLITHEMDVIKSVCDSAALMRGGRVVESGELTDLLAEPGSELARELFPLSEFGTGHPGTTVLEITFQGDTPAQPFVSQLARTYQIDINILGAAVETIAGRMVGRMRVELPGGHQDNVVPIGYLREQGLQVDVIGTANGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N3</accession>
    <name>A0A1E7N5N3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF305 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000646.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene871"/>
    <dbReference type="EnsemblBacteria" id="ARF82944">
        <property type="protein sequence ID" value="ARF82944"/>
        <property type="gene ID" value="B6264_20050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35954">
        <property type="protein sequence ID" value="OEV35954"/>
        <property type="gene ID" value="HS99_0007275"/>
    </dbReference>
    <dbReference type="OMA" id="MTWMGMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22675" checksum="DD592DB45C0E0B78" modified="2017-01-18" version="1">MWWPAVLAAVVALALGVPALVAGGTSASGSSSIAVPADDSPEAGFARDMATHHQQAVDLSFIVRDRTSDEPTRTLAFDIINTQANQRGMMTGWLDQWGLSQHSTAKPMTWMKMDHDYQAHDGSLMPGMATNAQMAKLRTLSGRDAEVYYLQLMIEHHKGGVEMAQGYVDMAKNDVEKRLAQSMVVAQTSELELMTGMLKERGAAPGVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N8</accession>
    <name>A0A1E7N5N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386135.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000230.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene498"/>
    <dbReference type="EnsemblBacteria" id="ARF78822">
        <property type="protein sequence ID" value="ARF78822"/>
        <property type="gene ID" value="B6264_07740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36016">
        <property type="protein sequence ID" value="OEV36016"/>
        <property type="gene ID" value="HS99_0031395"/>
    </dbReference>
    <dbReference type="OMA" id="WRGIAGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23960" checksum="E95C3454F1626504" modified="2017-01-18" version="1">MTAIQEAQERPRGARLPRSARREQLLGAAQEVFVAQGYHAAAMDDIADRAGVSKPVLYQHFPGKLELYLALLDKHCDALVESTREALGTTTDNKLRVAATMEAYFNYVSSESGAFRLVFESDLTNEPAVRERVERASEASATLVSKVIQEDTDLPESESKLLAAGVCGLAQITARYWLSQGLEIPRDEAVRLVASLAWRGLKGFPMHPGDLTAEGSAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N602</accession>
    <name>A0A1E7N602_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553177.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000457.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5002"/>
    <dbReference type="EnsemblBacteria" id="ARF80067">
        <property type="protein sequence ID" value="ARF80067"/>
        <property type="gene ID" value="B6264_15105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36121">
        <property type="protein sequence ID" value="OEV36121"/>
        <property type="gene ID" value="HS99_0031125"/>
    </dbReference>
    <dbReference type="OMA" id="HRWLLRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="22500" checksum="880A433C3868DA1B" modified="2017-01-18" version="1">MASRTAPDPARRSERARAAVLTAAAELVAEVGYGKLTIEAIAARAGVGKQTIYRWWPSKGAVVFDAFLAVNQHEGGLALPDTGDLAADLRAVLRPTSDELTDPRADRTYRAIIAELLNDPVLHSEYRTRLLDPLLEVTRDRLRAAREAGQLAPDADLDLAVELVYGPLYYRWQYRLGPLTHEHADRLVDAALRALNHPAASGTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N643</accession>
    <name>A0A1E7N643_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366716.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36161">
        <property type="protein sequence ID" value="OEV36161"/>
        <property type="gene ID" value="HS99_0030375"/>
    </dbReference>
    <dbReference type="OMA" id="PLFRFMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="23585" checksum="943ECA588B837AF5" modified="2017-01-18" version="1">MGTPHSPRSDTRARIIEVSLELFSEHGYEQTSLREIADRLGVTKAALYYHFKTKDDIVLGIVERMAAPIDETIAWGREQEWSPDTRDELIRRFADGMAERAPLLRFFHENQPALRESPAGLAFKERIITMMQLVHGPEASFQDRLRAAMTLFTVHSSMFLLQHDGKDPVPAENVWGEKVPVADLDEALEAARTVALEIGGRISHPARVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N662</accession>
    <name>A0A1E7N662_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284339.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000538.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8101"/>
    <dbReference type="EnsemblBacteria" id="ARF79793">
        <property type="protein sequence ID" value="ARF79793"/>
        <property type="gene ID" value="B6264_13545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36181">
        <property type="protein sequence ID" value="OEV36181"/>
        <property type="gene ID" value="HS99_0030495"/>
    </dbReference>
    <dbReference type="OMA" id="YVPKIGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="34130" checksum="0724009D9638D971" modified="2017-01-18" version="1">MRLGVLDVGSNTVHFLVVDAHPGAAPLAAYSHKAELRLAELLDESGAIGEAGVERLIGHVASSLRVAEDKGVVDILPFATSAVREAANGEQVLRRVADETGVELRVLSGQDEARLTFLAVRRWFGWSSGRLLNLDIGGGSLEIACGLDEQPDVACSLPLGAGRLTARWLPGDVADPDGLRELRRHIRAEIAHVVGEISRLGPPQHAVATSKTFRQLARMTGAAPADAGPYADRRLTRSGLSAWLPRLSTMTVAERAQIPGVSEGRAKQLLAGALVADAAMDLFGLEELDVCPWALREGIILRQLDSMDSSSTERRPALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N694</accession>
    <name>A0A1E7N694_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284264.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8062"/>
    <dbReference type="EnsemblBacteria" id="ARF79824">
        <property type="protein sequence ID" value="ARF79824"/>
        <property type="gene ID" value="B6264_13745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36211">
        <property type="protein sequence ID" value="OEV36211"/>
        <property type="gene ID" value="HS99_0030690"/>
    </dbReference>
    <dbReference type="OMA" id="PCRTEIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21282" checksum="C3937F757FF63BBD" modified="2017-01-18" version="1">MSAMTRPRPRVAAAAATVAAAALVLTGCSSSGSSSSGEGQVGFVTVKGTNLSKADAGKRGDAPDVSGETLEGNQVKLSDYRGKVVVLNVWGSWCGPCRAEAKNLQAVADEYKDKGVQFLGINTRDTDKTNAVRFEQEQGVSFPSIFDPAGTQLLKFPKGSLNPQSIPTTLVVDRDGKLAARAVGGTTQEALESIVQPVVAEQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J1</accession>
    <name>A0A1E7N6J1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2606"/>
    <dbReference type="EnsemblBacteria" id="OEV36311">
        <property type="protein sequence ID" value="OEV36311"/>
        <property type="gene ID" value="HS99_0030355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="11779" checksum="0A08841F7767FA86" modified="2017-01-18" version="1">MDGAEVDVDTNFFEAGANSIHLVRVQRRIAEDFGQELSVVEMFDRPTIRHLADLLDRPAPAAAAEPSPAPGSSARPEAPTEAPSAGGDRRQHHERRRAARRGGSGTNPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P0</accession>
    <name>A0A1E7N6P0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280530.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000931.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7730"/>
    <dbReference type="EnsemblBacteria" id="ARF82331">
        <property type="protein sequence ID" value="ARF82331"/>
        <property type="gene ID" value="B6264_28740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36377">
        <property type="protein sequence ID" value="OEV36377"/>
        <property type="gene ID" value="HS99_0029925"/>
    </dbReference>
    <dbReference type="OMA" id="DMTLFRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23387" checksum="1AD91165C7A02D15" modified="2017-01-18" version="1">MPAETPDLRVRTWSPVCRAVALLLGPYAEVVLHDTATDRVLAIWNPMTTRAPGDPSLLGELDELDPSAPDVYGPYEKLLPDGRRLSSVSAVLRDEAGRASAVLCVNLDRGPLEQAAALLTNFAAPTAPRPEPLFERDWTERMNDVIGGHVRAQGRPLERFTREDRLAVLRELDEAGVFAVRRAVPAVATALRISRSTAYALLAELKHPAGPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N760</accession>
    <name>A0A1E7N760_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000302.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1446"/>
    <dbReference type="EnsemblBacteria" id="ARF79167">
        <property type="protein sequence ID" value="ARF79167"/>
        <property type="gene ID" value="B6264_09760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36530">
        <property type="protein sequence ID" value="OEV36530"/>
        <property type="gene ID" value="HS99_0028820"/>
    </dbReference>
    <dbReference type="OMA" id="AYCHEEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="29642" checksum="13F43CE46D82720D" modified="2017-01-18" version="1">MLSTRSLFDEIYRNDQAYQLFCSIAAGGEDQGGWENERISALTRDPVLAPKIARHGADERKHGRIFTQLLNKRGLPKVPVPDEADYCMLLERKGIGLSHERLNGAAPLSVREIITYLAHSRVTEQRAAEQMRQLVKVYGDTPELGRAMRMISADEDNHLAYCHEELLRLTAEGHGPYIRHALETSARGEIRTHRDVGLAVAARMARILGWSRRQLALVTLGVHALYLYDRAFGWRRMVTLRMPERRNALGTPAPPHAEHEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N766</accession>
    <name>A0A1E7N766_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0028890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291194.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000557.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1433"/>
    <dbReference type="EnsemblBacteria" id="OEV36541">
        <property type="protein sequence ID" value="OEV36541"/>
        <property type="gene ID" value="HS99_0028890"/>
    </dbReference>
    <dbReference type="OMA" id="ASFGIGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="456"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="595" mass="63913" checksum="4063D4C17A7BFBEB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A0</accession>
    <name>A0A1E7N7A0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7891"/>
    <dbReference type="EnsemblBacteria" id="ARF79138">
        <property type="protein sequence ID" value="ARF79138"/>
        <property type="gene ID" value="B6264_09595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36558">
        <property type="protein sequence ID" value="OEV36558"/>
        <property type="gene ID" value="HS99_0028990"/>
    </dbReference>
    <dbReference type="OMA" id="LKLGWPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="545" mass="60614" checksum="E588CF1461250434" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E4</accession>
    <name>A0A1E7N7E4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554815.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000727.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7761"/>
    <dbReference type="EnsemblBacteria" id="ARF82306">
        <property type="protein sequence ID" value="ARF82306"/>
        <property type="gene ID" value="B6264_28590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36611">
        <property type="protein sequence ID" value="OEV36611"/>
        <property type="gene ID" value="HS99_0027925"/>
    </dbReference>
    <dbReference type="OMA" id="DVHPCAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14330" checksum="31EA02D8CE862353" modified="2017-01-18" version="1">MEADGPEVRAYIAALVRMGAPEVPGPPALAVPAGTAAEVTAVTRRLALRALPDRQRRPEPTPRLLAVARGLVVDVHPCAPGWTVAERERLAGWVAVLIEHRGEDGVQELVRELCREPGREGPGRDGPGREIDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R4</accession>
    <name>A0A1E7N7R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027405</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480704.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000853.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4769"/>
    <dbReference type="EnsemblBacteria" id="OEV36747">
        <property type="protein sequence ID" value="OEV36747"/>
        <property type="gene ID" value="HS99_0027405"/>
    </dbReference>
    <dbReference type="OMA" id="PWNRQRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="42671" checksum="19E0977F4EC6B2E8" modified="2017-01-18" version="1">MSPHQPTSRPAAGAPGVPWNRQRLRSNNEWLLLELLRTGGGTSRAQLARDTGLSKPTVSAALADLEQAGLVREAGWVSPERGRTAVLYEVDPTAGHVLGVDIGRARLRVAVADLAGTVVARRDVANRGRTADAVADAVVAAAREATAEAGLGAADIVHAVIGTPGVWDEERRGVRYATSLPGWGRPGLFDRIGEGLGTAVTVANDANLAALGEYTLGAGRGSRMFAYLLVGTGLGLGVVKDGELLLGAHGALGEIGLVPLPALAGGQPGVEGAVGGPGGTTLEQEAAADAVVRAAREFGLEGSGGRQLTAKRVFELARAGDAAALRAVHWEAERLAYAVAVLSAVLDPDLLVLGGGIGSSADLLLEPLEQALGRFSLMRPTLAPSLLGEEAVLLGAVSTALETARPEVFERRTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7W8</accession>
    <name>A0A1E7N7W8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0027760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284570.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4843"/>
    <dbReference type="EnsemblBacteria" id="ARF82417">
        <property type="protein sequence ID" value="ARF82417"/>
        <property type="gene ID" value="B6264_29250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36802">
        <property type="protein sequence ID" value="OEV36802"/>
        <property type="gene ID" value="HS99_0027760"/>
    </dbReference>
    <dbReference type="OMA" id="WLWAIIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9761" checksum="05270D2C8B239E57" modified="2017-01-18" version="1">MFQLLWILLIGFVLGVLAKLILRGPQSIPWWLTMLLGAAGALLGNAVSGWIGVRHTSGIDWIRHILQLAFAVALVALVAPAWSRNRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N886</accession>
    <name>A0A1E7N886_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2490"/>
    <dbReference type="EnsemblBacteria" id="ARF81510">
        <property type="protein sequence ID" value="ARF81510"/>
        <property type="gene ID" value="B6264_23660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36683">
        <property type="protein sequence ID" value="OEV36683"/>
        <property type="gene ID" value="HS99_0028375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13787" checksum="AB8314C9E8CF1F2A" modified="2017-01-18" version="1">MRKKLAATVLGGTAVLGLALGTSPASAASWHYAWFDTHTPTTGWSTKNIGLGPGGSSVRFDVWCSGGGSYKVEIRKAGVGIGVSQADHVPCDGHWYSVTTKHLNTRWAYYAHLSTHNGKRPLQVAAYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E0</accession>
    <name>A0A1E7N9E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37299">
        <property type="protein sequence ID" value="OEV37299"/>
        <property type="gene ID" value="HS99_0005775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15275" checksum="BB46C715DAD427F7" modified="2017-01-18" version="1">MPGEIEFAVDCGNARRLRATPGRVAQEPAVPVSDAEARRLTGALRESVEQVRSAVLVLTERVRAAYRRRVWVALGYPSWGAYAAGELEVSRSTAYRLLDLAAAAEAIEDVAERDAEEVLHVLAEEIGAAAPRNYSRAAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E3</accession>
    <name>A0A1E7N9E3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5476"/>
    <dbReference type="EnsemblBacteria" id="OEV37320">
        <property type="protein sequence ID" value="OEV37320"/>
        <property type="gene ID" value="HS99_0005900"/>
    </dbReference>
    <dbReference type="OMA" id="GPKTWNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198994" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="35442" checksum="168C7286958948B6" modified="2017-01-18" version="1">MSLGLALASVLTGVGAYTAAAAPAAAAPAPIPLTSSACPADLQQGEADGCVTQLQLELNLTGAQLTVDGQFGSATGTAVRTFQASHSLTADGIVGPATKSALDAAAAAASATVDLRTQCGDLQTGAGGACVSTLQTMLNTFHAGRLTVDGQFGPATDTAVRNFQAAHTLTIDGIAGTAVKNALYTSTPAPLPSGAVDPIKVLNAAKSYLGVKYVWGGGHSLRGEGPGPSLGTCDQYTGPQPCAANTTVGLDCSGLVRAAFWFGAGIDLAHGGGTTEQTLDSHLTPITESQRRPGDVEYFGADAHNTVHVVLYAGTDPTTGADMMYEAKETNTNVHYVTLRTGGYWYHVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G3</accession>
    <name>A0A1E7N9G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556503.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5463"/>
    <dbReference type="EnsemblBacteria" id="OEV37331">
        <property type="protein sequence ID" value="OEV37331"/>
        <property type="gene ID" value="HS99_0005970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6448" checksum="A45702337B223EB3" modified="2017-01-18" version="1">MSISAVAGFSSAARRRSVTAERTPEATVPTMTTSSRGKDRQRRSHARPDPSSPACSQTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K7</accession>
    <name>A0A1E7N9K7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37369">
        <property type="protein sequence ID" value="OEV37369"/>
        <property type="gene ID" value="HS99_0006205"/>
    </dbReference>
    <dbReference type="OMA" id="YMGDDNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="27211" checksum="ABA2443A5777E001" modified="2017-01-18" version="1">MYATPGTYEFTVPKGVTQLTATAVGAGGSGGGGGSGGNGNQFQFGGGGGGGAGGNGGGAVECVFPVKPGQVIHLAVGKGYPGGRGSHSWDPENRYNGEGGYGGDYGDDSWVWDKTTNNSIRARGGLGAWGGGGGESAKGSSQTTRDLSGKGGKGGPSNERVGGGTWDTRGPKCANDALARGGKFGDSGRNGEDGNHDRGDGRGGDGGRGGAAGVTTPWGAIVPLPSMAACPENARGKGGDGGRGGDAGDWNRNYDNFYPKPGEDGKAGQSGCLVLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N6</accession>
    <name>A0A1E7N9N6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558119.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000649.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82513">
        <property type="protein sequence ID" value="ARF82513"/>
        <property type="gene ID" value="B6264_29855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37399">
        <property type="protein sequence ID" value="OEV37399"/>
        <property type="gene ID" value="HS99_0006375"/>
    </dbReference>
    <dbReference type="OMA" id="WAAHPED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="31007" checksum="047568BAA262F7B6" modified="2017-01-18" version="1">MTTRTMDTAQELAAFLRSRRERLDPGRLGLPSHRRARRTPGLRREEVAELAGISADYVVRLEQGRGLRPSAEVLAALARALRLDPGERDYLFDLAGRRRPGTTGGSASGVAPSLAHLVDDLSPLPAMLLDRRYDILAWNPEMARLLPDFDAVAPSRRNAMRLCLLHPAMRGFYADREQVLRDGIAHLRAAWAAHPKDRALSCLIAEFATQDADFARLWSEREVGVNGRGRKVLRHPVAGALTIDFEVLLPLQDPDLRLLVYRAADEESRAALERLCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y6</accession>
    <name>A0A1E7N9Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7979"/>
    <dbReference type="EnsemblBacteria" id="ARF79066">
        <property type="protein sequence ID" value="ARF79066"/>
        <property type="gene ID" value="B6264_09175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37507">
        <property type="protein sequence ID" value="OEV37507"/>
        <property type="gene ID" value="HS99_0026180"/>
    </dbReference>
    <dbReference type="OMA" id="RAFECWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="43175" checksum="34B7DD786469F673" modified="2017-01-18" version="1">MNEERHDALRSLLGAWSLGACPPRESAELERHLRGCAECTEEAARLRDAAGWLSLDEPLDQPGSLRQQVLDWCLARRPAELPVPAWGMPYTAETAKLDALLRDLGPEEWQEVAELPWHGGAELLRPAEVLGRLTAVDGFLALALGLPDPVPAAAPSAPARARVVERRVPPQEAAVPAPRVPRVPPQGGPSTAVTARTARLLADQAGLPPQSVRARWRQQTHDLVRGAALAPQGSTPVDLGFAVLPLRDAFVDRALECFVHGEDVARAVAYPYDPPAPQHLRQMVELVVRLLPRALAGLRAARPQPAGAPGTAGPAGATAVREPRRLRLVVDGPAAGEWLVPLGGEQAGPPGGEPVASMVLDGLELCQLAAAHRDPDRLPVGEHGDRAAVREVLHALPLLSRPRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA20</accession>
    <name>A0A1E7NA20_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1158"/>
    <dbReference type="EnsemblBacteria" id="ARF79034">
        <property type="protein sequence ID" value="ARF79034"/>
        <property type="gene ID" value="B6264_08985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37536">
        <property type="protein sequence ID" value="OEV37536"/>
        <property type="gene ID" value="HS99_0026370"/>
    </dbReference>
    <dbReference type="OMA" id="ITRWGNQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="544" mass="57186" checksum="D8A745E2BEDBA5D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA71</accession>
    <name>A0A1E7NA71_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-1-antitrypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1107"/>
    <dbReference type="EnsemblBacteria" id="OEV37579">
        <property type="protein sequence ID" value="OEV37579"/>
        <property type="gene ID" value="HS99_0026625"/>
    </dbReference>
    <dbReference type="OMA" id="GWTPIGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198930" evidence="2">
        <location>
            <begin position="34"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="49"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="46458" checksum="F2E7566A8C12B74D" modified="2017-01-18" version="1">MNTGRRPKTRLGSLLAALAITGASLLLGLPAHADEPSAGASAAPKENPRVDLILDVSGSMNIADIQGKSRISVAQNSLNEVIDALPGETDFGIRTLGATYPGNDKTAGCQDTKQLFPVGKTNKVEAKTAVATLRPTGWTPIGLALRGAAQDLGKGDATRRIVLITDGEDDCAPPDPCDVARELAAQGIHLVVDTLGLAHDDKTTQQLICIANATGGSFTDVRTPQQLTDKVKQLVDQSNDTYTINPVRTTGTDKCESAPVLTPGVYSDREKFSEHRVYKVPVKSGQELRASVSVGLDRAMARDYGVLLQATSATGQELVRGTDAGSTRTDVISTGLRWSTDDSKGYVTASPTTSAKDKDKPDTTVCLVVSNSLAPQAGVHTDPGMPLELTVDLASASPAPEGAAMGLGRGWILLLTLTLAGLFSGLVAGWIARWRIAVWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAA1</accession>
    <name>A0A1E7NAA1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286482.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1127"/>
    <dbReference type="EnsemblBacteria" id="ARF79007">
        <property type="protein sequence ID" value="ARF79007"/>
        <property type="gene ID" value="B6264_08830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37564">
        <property type="protein sequence ID" value="OEV37564"/>
        <property type="gene ID" value="HS99_0026525"/>
    </dbReference>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="36443" checksum="C3E1E1DD006A52C3" modified="2017-01-18" version="1">MATRAVVRDRADRTRAARPTNLEADRDLVGMYLDEIARTPLLDAAEEVELSLRIEAGVYAQHMLDEGELPDGVTREELEAIAADAERAKDVFIRSNLRLVVAVARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYAKGFKFSTYATWWIRQAITRSIADQSRTIRLPVHLVEELGRIRRVQREKSKELGREAEPAEIAAELDTTEARIKDVLDWARDPVSLNMSVDDEGETQFGDLVEDTGATSPEDAVMVMLRREELDDLIGRLDDRTASIIRSRYGMEDGRERTLTEVGKQHGLTRERIRQIEKHALAELKKIADHAGFEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ8</accession>
    <name>A0A1E7NAJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553958.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1690"/>
    <dbReference type="EnsemblBacteria" id="ARF79921">
        <property type="protein sequence ID" value="ARF79921"/>
        <property type="gene ID" value="B6264_14310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37664">
        <property type="protein sequence ID" value="OEV37664"/>
        <property type="gene ID" value="HS99_0025520"/>
    </dbReference>
    <dbReference type="OMA" id="ANICVST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="685" mass="73012" checksum="3602182E3E78D3CD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL0</accession>
    <name>A0A1E7NAL0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0025865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385624.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4913"/>
    <dbReference type="EnsemblBacteria" id="ARF79985">
        <property type="protein sequence ID" value="ARF79985"/>
        <property type="gene ID" value="B6264_14655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37726">
        <property type="protein sequence ID" value="OEV37726"/>
        <property type="gene ID" value="HS99_0025865"/>
    </dbReference>
    <dbReference type="OMA" id="WEYTWTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="594" mass="63223" checksum="AE1DA7ECF35C8DB4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM7</accession>
    <name>A0A1E7NAM7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ORF">HS99_0025320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6246"/>
    <dbReference type="EnsemblBacteria" id="OEV37739">
        <property type="protein sequence ID" value="OEV37739"/>
        <property type="gene ID" value="HS99_0025320"/>
    </dbReference>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="93"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="30698" checksum="43F24E596A944F7F" modified="2017-01-18" version="1">MDAAELADDAESAEQIVDAADSDEDEVEAYDEAESGEAAEESALHVEAAEAEDGTEELAAEADDETEAEESAAEAEAEVDPVAKFREDLRFMPGEWYVIHTYAGYENRVKQNLEQRAVSLNVEEYIFQAEVPQEEVVQIKNGDRKTIRQNKLPGYVLVRMDLTPESWGVVRNTPGVTGFVGNAYDPYPLTLDEVVKMLAPDVERQAAKEAGKPSPVKPTEIQVLDFEVGDSVTVTDGPFATLQATINEINPDSKKVKGLVEIFGRETPVELSFDQIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB01</accession>
    <name>A0A1E7NB01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3441"/>
    <dbReference type="EnsemblBacteria" id="OEV37859">
        <property type="protein sequence ID" value="OEV37859"/>
        <property type="gene ID" value="HS99_0024475"/>
    </dbReference>
    <dbReference type="OMA" id="WLELADF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="206"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="737" mass="78475" checksum="893C6BBAB6DA820A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB41</accession>
    <name>A0A1E7NB41_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0023785</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2122"/>
    <dbReference type="EnsemblBacteria" id="ARF79449">
        <property type="protein sequence ID" value="ARF79449"/>
        <property type="gene ID" value="B6264_11455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37899">
        <property type="protein sequence ID" value="OEV37899"/>
        <property type="gene ID" value="HS99_0023785"/>
    </dbReference>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="248"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV37899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="39994" checksum="E4A2E44CAC3F3055" modified="2017-01-18" version="1">MKFRVERDVLAEAVAWAARSLPARPPVPVLAGLLLTAQEGSLALSGFDYEVSARVELEADVEEAGTVLVSGRLLNDISRNLPNRPVEISTDGQRVSVVCGSSRFTLPTLPVDEYPALPQMPTATGTVSGDVFASAVSQAAVAAGRDDTLPVLTGVRVEIEGDRITLAATDRYRFAVRDLLWKPEQSDISAVALVPAKTLQDIAKSLGSGDTVSIALSSGGAGEGLIGFEGAGRRTTTRLLEGEFPKFRSLFPTEFSAVAAIQTQPFLEALKRVSLVAERNTPVRLNFEQGVLTLEAGSGDDAQATERIEADLEGDDISIAFNPGYLEEGLKAIDSPFAQLSFTTPTKPALLSGKVSVDSEEDKAYQYLIMPVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB69</accession>
    <name>A0A1E7NB69_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="7" type="ORF">HS99_0023985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552083.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2083"/>
    <dbReference type="EnsemblBacteria" id="ARF79484">
        <property type="protein sequence ID" value="ARF79484"/>
        <property type="gene ID" value="B6264_11655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37931">
        <property type="protein sequence ID" value="OEV37931"/>
        <property type="gene ID" value="HS99_0023985"/>
    </dbReference>
    <dbReference type="OMA" id="AGITFKY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22541" checksum="0FC0870F5A77C54B" modified="2017-01-18" version="1">MPTLLHIDSSAITDGSVSREVTAAFRAAWEAEHPGGTVIHRDLAAEPVPHLDAHGITAGYAPAEARDAEQAAAFALRERLITELESADAVLIGAPMYNFTIPSTLKAWLDHVILMGRTAGESPSAKGTPVTVVASRGGSYGPGAPREPFEFVTTYLEKVLGGGLGLEVEFIVPEFTLAASVPALAEFVPAAAESRARALELAARRGKELAARFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE3</accession>
    <name>A0A1E7NBE3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="4" type="ORF">HS99_0023820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2116"/>
    <dbReference type="EnsemblBacteria" id="OEV38009">
        <property type="protein sequence ID" value="OEV38009"/>
        <property type="gene ID" value="HS99_0023820"/>
    </dbReference>
    <dbReference type="OMA" id="WDRHVLN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26077" checksum="15A7D886CA7859D0" modified="2017-01-18" version="1">MDVLAEAPAAAREVFGDRFDAAVRYTELLATAGVRRGLIGPREVPRLWDRHVLNCAVLAELLPSGSTVCDVGSGAGLPGIPVALARPDVSVTLLEPLLRRTTFLEEVVRELALENVTVLRGRAEEMVGKLAVDVVTARAVAPLDRLAGWGMPLLRPHGQMLALKGDSAEQELADSRAGLAKLGAVEWSVISVGEGTLETSTRVVQVKAGESPGGVKAATRRAKVARAGRNAGAKNGTTAGRGGRRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW0</accession>
    <name>A0A1E7NBW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0023220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5946"/>
    <dbReference type="EnsemblBacteria" id="OEV38186">
        <property type="protein sequence ID" value="OEV38186"/>
        <property type="gene ID" value="HS99_0023220"/>
    </dbReference>
    <dbReference type="OMA" id="LNCAYWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198983" evidence="2">
        <location>
            <begin position="28"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="116"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="527" mass="54974" checksum="7B1E9A1FE29D47A6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC98</accession>
    <name>A0A1E7NC98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4162"/>
    <dbReference type="EnsemblBacteria" id="ARF80169">
        <property type="protein sequence ID" value="ARF80169"/>
        <property type="gene ID" value="B6264_15730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38312">
        <property type="protein sequence ID" value="OEV38312"/>
        <property type="gene ID" value="HS99_0022540"/>
    </dbReference>
    <dbReference type="OMA" id="HLKKQWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="610" mass="67328" checksum="678AD5DAB407E340" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP7</accession>
    <name>A0A1E7NCP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82128">
        <property type="protein sequence ID" value="ARF82128"/>
        <property type="gene ID" value="B6264_27540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38476">
        <property type="protein sequence ID" value="OEV38476"/>
        <property type="gene ID" value="HS99_0021505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="7242" checksum="B39D3F874348B4B8" modified="2017-01-18" version="1">MRWWARPGTAVCRGDTEAERQFIDTIGPEYWVETLASGPPEGYQAWQDSVGAAAELLCRAEAPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX2</accession>
    <name>A0A1E7NCX2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate--cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288356.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3103"/>
    <dbReference type="EnsemblBacteria" id="ARF83101">
        <property type="protein sequence ID" value="ARF83101"/>
        <property type="gene ID" value="B6264_27335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38508">
        <property type="protein sequence ID" value="OEV38508"/>
        <property type="gene ID" value="HS99_0021710"/>
    </dbReference>
    <dbReference type="OMA" id="CRRRVNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="501" mass="56078" checksum="73ABB36E12BC7138" modified="2017-01-18" version="1">MGEKVVATRADLADRQQYRLKLQACLDALGRMLREDRFDRPRAVMGLEIELNLADEQGLPVLRNAQVLSAIGSSDFQTELGQFNIEVNIVPHRLCGHVFEELREEIDTGLRYADRQAAEAGARIVMVGILPTLESDHTGLDAMSHNQRYSLLSDQILAARGEDIALDIEGVEHLQLESITMVAEAAATSLQLHLQVTPERFSSVWNAAQAICGPQLALGANSPFLFGRELWRETRPVLFQQACDTRSAELKAQGVRPITWFGERWVDSAYDLFEENLRYFPALLPICDDEDPLKVLTSGGAPRLAEMRLHNGTIYRWNRPVYDVAGGVAHLRVENRALPAGPTVADTLANAAFYYGLVRVLAEQPRPVWTRLPFERADENFRQGARYGIDAVFQWPRPGRAGRGGGLQTVSAVDLVLNELLPMAHQGLDEWGVEPADRDRYLGIIEQRCLRRTNGAAWQSATFHRLREQYGMDRPAALAAMTRRYAEHMRGGEPVHTWPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND30</accession>
    <name>A0A1E7ND30_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene607"/>
    <dbReference type="EnsemblBacteria" id="OEV38616">
        <property type="protein sequence ID" value="OEV38616"/>
        <property type="gene ID" value="HS99_0020355"/>
    </dbReference>
    <dbReference type="OMA" id="NEVCDVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="40329" checksum="1A7C0FE52907C4C1" modified="2017-01-18" version="1">MPFAFDAPFDRTGTGSSKWARAAAPGVIPMGLADMDLPGPPAVAEALERRARHRAYGYTVCDPAGRTLVADWYRTRHGAEVDPDWVLLLPCGPRTALRHLLETVRTDAAQPQPPVLFPTPEWGGFAQLCRAAGLPYLELPLPLGLDGYRLPRGPFAGPASAVLLSNPHNPSGTVWPPGRLRSLAEYAAEADALLVSDEVHGDLTHPGRAHPVAVTTVEPALRRRVVTLNSVGKTFNCSGIPSSFALVPDPGLRARLTDTLAGYGLWEGGLLEQTVQRAALAEGGPWLDALLAHLAAARTRLTDRLGPAVRSTPHASYLLWLDAAALGLPPATARAALLERCGLEASDGAEFGPGGTGSLRLNYALPGPVLDTVLERLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG2</accession>
    <name>A0A1E7NDG2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283014.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000313.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82545">
        <property type="protein sequence ID" value="ARF82545"/>
        <property type="gene ID" value="B6264_01195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38730">
        <property type="protein sequence ID" value="OEV38730"/>
        <property type="gene ID" value="HS99_0020780"/>
    </dbReference>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="36231" checksum="2FA0748C9D7B3110" modified="2017-01-18" version="1">MSYLAADDRYASMTYRKAGRSGVQLPAVSLGLWHNFGDSQPLDVQRAVLRRAFDRGVTHFDLANNYGPPYGSAERNFGYLFAQDFRPYRDELFIATKAGWDMWPGPYGNGSSRKYLLASLDQSLGRMGLDYVDVFYSHRYDPDTPIEETMGALDSAVRSGKALYAAISNYPAEQHREAAAILRELGTPALMNQSAYSILDRHVEEAGVLDAVGDTQTSLIAYSPLAQGLLTDRYLSGQVPAGSRMSVGRFLTEEVLTGPKLEQLRALNKVAERRGQSLAQLALCWVLRDPRVVSVIIGASSVAQLDQNLDALAGGPLTEEELAEIDRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDP3</accession>
    <name>A0A1E7NDP3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290263.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7385"/>
    <dbReference type="EnsemblBacteria" id="ARF81199">
        <property type="protein sequence ID" value="ARF81199"/>
        <property type="gene ID" value="B6264_21900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38792">
        <property type="protein sequence ID" value="OEV38792"/>
        <property type="gene ID" value="HS99_0019165"/>
    </dbReference>
    <dbReference type="OMA" id="FVALVYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20627" checksum="E5455740C6FECA5C" modified="2017-01-18" version="1">MDYATLAREQAKVTDWPAYIGWSIGLLIIIGLVYWLMRQGWNWRRTLQSGIPPLPAVPARAGRTILETSGRYHGTTTAGNWLDRVVAHGLGTRSRADLTLGEDGLLVQRPGDVDLWIPAEHLTGARTDSGIAGKVVPAGLLVVTWTHEGTELDSGFRADHPDEHTAWVEAITQLATRTKTKKTEEAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE26</accession>
    <name>A0A1E7NE26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555453.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6525"/>
    <dbReference type="EnsemblBacteria" id="OEV38888">
        <property type="protein sequence ID" value="OEV38888"/>
        <property type="gene ID" value="HS99_0019730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11125" checksum="167A5D43ACA466D9" modified="2017-01-18" version="1">MGDNPTGYTVKPDALDGVTTALGNVATDLTNANQAYTAQKPSQSADFGEFGVDQAWSGFDTNWGQELHVTQRAVGELVQKMSATSANYRAAETKVTASLSPKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA3</accession>
    <name>A0A1E7NEA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557898.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000804.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6277"/>
    <dbReference type="EnsemblBacteria" id="ARF81228">
        <property type="protein sequence ID" value="ARF81228"/>
        <property type="gene ID" value="B6264_22080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38823">
        <property type="protein sequence ID" value="OEV38823"/>
        <property type="gene ID" value="HS99_0019345"/>
    </dbReference>
    <dbReference type="OMA" id="PEVIWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24558" checksum="45BE6A1EBE87BB6D" modified="2017-01-18" version="1">MPPEAPELIWLRPERTGRGPRPAHSRDSIAAAAIVIADAEGLEAVSMRRVAAALGAGTMSLYNYVPKKEHLLDLMLDAACAEYRLAPGPSGDVRADLTRLGHEQLTIFRRHPWLPALVVARPGIGPNALRYTDHFLAVTAPTGLPGGARMEAMAMFNGFICQFAQYEQTAAAGAKWQAEMVGYLTQAAMSGDYPHLAQAFATSGPPADPDQAFDRALDRVILAVLASVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF5</accession>
    <name>A0A1E7NEF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4071"/>
    <dbReference type="EnsemblBacteria" id="OEV39080">
        <property type="protein sequence ID" value="OEV39080"/>
        <property type="gene ID" value="HS99_0018500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="10312" checksum="ABAEFDEB06A10C36" modified="2017-01-18" version="1">MILWIRRKHPRLTWKRLRRLYFGADCITEGGIVLYSPARVRVERYRYRGAQISTRYNVDEVNPDGARVRRTTHDDVAFVGQVSEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH0</accession>
    <name>A0A1E7NEH0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557527.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1032"/>
    <dbReference type="EnsemblBacteria" id="ARF83266">
        <property type="protein sequence ID" value="ARF83266"/>
        <property type="gene ID" value="B6264_30475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39035">
        <property type="protein sequence ID" value="OEV39035"/>
        <property type="gene ID" value="HS99_0018205"/>
    </dbReference>
    <dbReference type="OMA" id="CEPIEWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045772">
        <property type="entry name" value="DUF6225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19735">
        <property type="entry name" value="DUF6225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9737" checksum="E0D74B0D3667ED1B" modified="2017-01-18" version="1">MADTDTYVHSPEVWTAGRLREAIKDLPDDAPIHIGVASDPGDFDGYQDHVLVDCEPIEWAGDDGAPERTEVEYTLFADWPAGTYDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH1</accession>
    <name>A0A1E7NEH1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxypenta-2,4-dienoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557519.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1027"/>
    <dbReference type="EnsemblBacteria" id="ARF83270">
        <property type="protein sequence ID" value="ARF83270"/>
        <property type="gene ID" value="B6264_30500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39038">
        <property type="protein sequence ID" value="OEV39038"/>
        <property type="gene ID" value="HS99_0018230"/>
    </dbReference>
    <dbReference type="OMA" id="IRDWSIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="27743" checksum="8BDDE0DCEEA2C3A6" modified="2017-01-18" version="1">MSEHGRTAVGVLEGDAARELRAAELSGIPTQTMAGRFQDLTLEQAYRIQRHGVDLRTAAGATPVGHKIGLTSLAMQQQMGVSEPDSGVLLADMAVPCGADLPMGLLLAPRVEAEIAVRIGADLAGPDVDLAAARAAVSEVFLALEVIDTRYGDWRIALVDSVADNASASRFALGPAMAADRLPDLGDEYVEVRVDGTLSASGHGRDVLGDPLLPLVWLAQRLTALGGGLSAGDLVLPGSVHASLPLRPGVTVEASSAHLPPVWFRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NES9</accession>
    <name>A0A1E7NES9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39148">
        <property type="protein sequence ID" value="OEV39148"/>
        <property type="gene ID" value="HS99_0018380"/>
    </dbReference>
    <dbReference type="OMA" id="THFKGWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="41406" checksum="1CAAB9D72A0AA4EB" modified="2017-01-18" version="1">MGFAASPAAAASATTTAPRLGDTCTAADLGTRHPIIKTTEVTPTITHFKGWYVTQGSTGSHTVTTSTQTTISVSVGLNGTVQGNFAVEALGSVGASLGLNVQVNYSSTSSESNSVSWNFFEPGYYGLYKGTKKVTGTYGSLNCNRTDLGGGTYGLKWTAGPDTGSYTTYTALEEGAVRCEDKVPANSIMRKAQDLLDCGSATAKHPAGSTPSAKDDKPAADETVLAEKSAKTTASQTPSTLAALSCQPAVYRIDVPGKTLNWSAPLLANDGIRLRESTFFSAHLDNWRLCNVTETNGVIEASLWNWGNGGCATIPANIANQEQAYLTTANCAEDDLQRFYIYRDVPGSSKIGLQNKYTGSMIAYDRYADGELIRQYSSGRQDGTGTFTLTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW5</accession>
    <name>A0A1E7NEW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285115.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3484"/>
    <dbReference type="EnsemblBacteria" id="OEV39175">
        <property type="protein sequence ID" value="OEV39175"/>
        <property type="gene ID" value="HS99_0000120"/>
    </dbReference>
    <dbReference type="OMA" id="YTWPADL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20566" checksum="2AC65BDE485A9544" modified="2017-01-18" version="1">MTSKILLVTGDAAESLEVFYPYQRLREEGYQVDIAAPTRKRLQFVVHDFVDGYDTYTEKPGYTWPADLALADVDPAAYVALVIPGGRAPEYLRNDPDVQRIARHFFEGDKPVAQICHGPLITAAAGLLDGRRTSAYPALAPDITAAGAEFVEGEAVVDGVVVSARAWPDHPAWLRAFIEVLRTKAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS2</accession>
    <name>A0A1E7NFS2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555660.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6784"/>
    <dbReference type="EnsemblBacteria" id="OEV39522">
        <property type="protein sequence ID" value="OEV39522"/>
        <property type="gene ID" value="HS99_0002195"/>
    </dbReference>
    <dbReference type="OMA" id="RRAHWWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="27"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15750" checksum="737621FE197A314F" modified="2017-01-18" version="1">MAGDLLQRRAHWWPSFSELFEDFPADLRMGEHLIRVEESEEDGAYVVKAELPGIDPDKDVEITFEGGVLTVHAERSEEKKEKQRSEFRYGSFTRSIRLPEGVKEQEITASYDNGVLTVKAPIGEVEKPTRRIEISRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX5</accession>
    <name>A0A1E7NFX5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0002765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550316.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000512.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2747"/>
    <dbReference type="EnsemblBacteria" id="OEV39611">
        <property type="protein sequence ID" value="OEV39611"/>
        <property type="gene ID" value="HS99_0002765"/>
    </dbReference>
    <dbReference type="OMA" id="IIWRDES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="52848" checksum="BF8E0ED0BD5A41DF" modified="2017-01-18" version="1">MPLKRAQEHHHISRDLELNPVFSREPVKVPRYALPKSEMEPETAYQLVHDELMLDGNARLNLATFVSTWTEPQALRLMGECAEKNMIDKDEYPQTAELETRCVHMLARLWNAPDAHRAVGCSTTGSSEAAMLGGLALKRRWQHRLAADGTTAKPNLVMGINVQICWEKFADYFDVEARYVPMEGERYHLSPEAAVELCDENTIGVVAVLGSTFDGSYEPVAELAAALDDLQERTGLDIPIHVDGASGAMIAPFLDPDLVWDFRLPRVASINTSGHKFGLVMPGVGWALWRDEQALPDDLVFHVNYLGGDMPTFALNFSRPGAQVVAQYYNFLRLGFDGYRRVQQTCRDVATRLAGEIAGLGPFELITDGSQTPVFAFRIRQGIDAFSVFDVSAALRERGWLVPAYTFPENRTDLAVLRIVVRNGFSHDLADLLLADLKRVLERLEHQSGPQRSADDAGGFAHGAETKNPKRPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG08</accession>
    <name>A0A1E7NG08_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="13" type="ORF">HS99_0002550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555590.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000784.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6711"/>
    <dbReference type="EnsemblBacteria" id="OEV39578">
        <property type="protein sequence ID" value="OEV39578"/>
        <property type="gene ID" value="HS99_0002550"/>
    </dbReference>
    <dbReference type="OMA" id="GRDQLDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="623"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="708" mass="73517" checksum="F50C0541247E7A5C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG16</accession>
    <name>A0A1E7NG16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367054.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39614">
        <property type="protein sequence ID" value="OEV39614"/>
        <property type="gene ID" value="HS99_0002780"/>
    </dbReference>
    <dbReference type="OMA" id="RERQWIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="27098" checksum="E8E630164006E1EC" modified="2017-01-18" version="1">MALFSPKCPVGPDERAWIEESMAWLAAEFGRAVLDRAPVLPTGEYFPGPFRGSEEDIRGVIAQICGYLDVAPNRLTIEIQPDDGEDAMVADLRLARRSRYAAGHYRRENGRPVIAVDQRQAARPVALVATVAHELGHVRLLDEQRIPADRHDHEPLTDLLTVHFGLGIFTANSAFNYSQDKQGWSYTRLGYLSERMFGYALACYAHRRGEAKPAWARHLTTNPRAYLKQGLRYLDRNPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV48</accession>
    <name>A0A1E7MV48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289852.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6882"/>
    <dbReference type="EnsemblBacteria" id="OEV32304">
        <property type="protein sequence ID" value="OEV32304"/>
        <property type="gene ID" value="HS99_0016475"/>
    </dbReference>
    <dbReference type="OMA" id="VHGSWTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="35480" checksum="659ADA792DA9018D" modified="2017-01-18" version="1">MNILLWHVHGSWTTAFVQGPHTYLLPVTEDRGPDGLGRARTFDWPHTVVELPPERLRGTDIDLVVLQRPHEAALAERWLGRRPGVDLPAVYLEHNSPHGDIPDTRHPMADRDDLTVVHVTDFNDLFWDCGSTRTTVIEHGVVDPGYRYTGELAASAVVVNEPVRRGRTTGTDLLPLFARQGPLHVFGMATGGLAAHLGLPPDRCRTAELPQAALHTELPRRRLYLHPVRWTSLGLSLLEAMHLGMPVVALATTEAVRAVPPGTGVLSTDVRELADAVRHYLADPAAATQDGLRARQAALERYGLKRFLADWDRLMEEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV64</accession>
    <name>A0A1E7MV64_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6902"/>
    <dbReference type="EnsemblBacteria" id="OEV32317">
        <property type="protein sequence ID" value="OEV32317"/>
        <property type="gene ID" value="HS99_0016560"/>
    </dbReference>
    <dbReference type="OMA" id="ACLHAPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="31"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17283" checksum="B527357F65900B65" modified="2017-01-18" version="1">MDPTGRGRAAAAGETRRLAFEGSAGAVQRSREFSRAALRSWHWLPADDEEQRARAEDVLLMVSELVTNACLHAPGGPRELRLDWDGVRLRVEVVDASPVLPRLARAADPSRPGGHGLRVVDRLARAWGAAPDDGGKLVWLEVGSPLDRHVRLDGFNRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE8</accession>
    <name>A0A1E7MVE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553889.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32398">
        <property type="protein sequence ID" value="OEV32398"/>
        <property type="gene ID" value="HS99_0017035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="30774" checksum="BFB8D911142561CF" modified="2017-01-18" version="1">MVRLWFMQQRGELAGVGSMVGLVAAAVLTETGTVGGGAAFLVMAAIVAVAALAAPHAYWLRADEDGLTLVRLLVPRHYAWADVRGLAMELGRDEENDGHHLTLRLRLAEPPGRFWGPRLGRIDVTDEDTPEGVPPRALAELFAVFVEHELPVDLPEFANEVLRVRGLPQLPPLPLWAPPVEGAPDPEQAYADAPGIEEERQDLVALGKAVKRRVRLGREHLLRRAALADRVFLRDGDGLALAIALGEAQRLVEHDRVRVEGDQRHYVRQQYLSRRALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI3</accession>
    <name>A0A1E7MVI3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290551.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1176"/>
    <dbReference type="EnsemblBacteria" id="OEV32435">
        <property type="protein sequence ID" value="OEV32435"/>
        <property type="gene ID" value="HS99_0017270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="15732" checksum="EBC28F975EEFA2C5" modified="2017-01-18" version="1">MAVHHVDPADALAALRTARRARAAARPRPLPGWYPATAAGLFALGFVLFGLSVLLPERLWLPAAGLQLAAAAALIGHVVVSHRVEHRPGIVPALPRPGAWFPAAAAHLPALAVSGVLALSYGPAGFLLALGPTCGLAHLLLLRRKRARAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU3</accession>
    <name>A0A1E7MVU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000093">
        <property type="protein sequence ID" value="OEV32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551929.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1910"/>
    <dbReference type="EnsemblBacteria" id="ARF79628">
        <property type="protein sequence ID" value="ARF79628"/>
        <property type="gene ID" value="B6264_12570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32550">
        <property type="protein sequence ID" value="OEV32550"/>
        <property type="gene ID" value="HS99_0040195"/>
    </dbReference>
    <dbReference type="OMA" id="YPMPMLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="36865" checksum="C8D859CCF260537C" modified="2017-01-18" version="1">MTRRPNLAVVGATGAVGEVLLGLLSLRQDIWGEVRLVASPRSAGRTPVVRGEPVEVVPLAEEAFAGIDVAVFAVPDAVSAQWAPIAAAKGIVVVDDSAAFRTAGDVPLVVPEVNAAALRIRPRGIVASPAGTTLALVAAVGALHAEYGLEQLVVATYQAASGEGREGMAALRDQTALVAGTEVGRQTGDLRAVIADEGPFAAPLALNAVPWTGGLCEGGWSAQELGLRDEARKILGLPALRVSATCVRIPVVRTHALAVHARFEREVSQEHAQDILRETPGVVLYDDPAAGEFPTPNDAVGTDPVWAGRVRRALDEPDALDLFLCGDNLRKGAALNLLQIAELVAGELSAGSPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU8</accession>
    <name>A0A1E7MVU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0040200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000093">
        <property type="protein sequence ID" value="OEV32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1909"/>
    <dbReference type="EnsemblBacteria" id="ARF79629">
        <property type="protein sequence ID" value="ARF79629"/>
        <property type="gene ID" value="B6264_12575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32551">
        <property type="protein sequence ID" value="OEV32551"/>
        <property type="gene ID" value="HS99_0040200"/>
    </dbReference>
    <dbReference type="OMA" id="QEDHEAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19764" checksum="2B073E9F5C995445" modified="2017-01-18" version="1">MTAAAPGAADSGAGTDAGTSEDLLTATYQAHYRSLLRLAALLLDDLSTCEDVVQEAFIRVHAARRRVREPEKTLAYLRQTVVNLSRSTLRRRILGLRLLPKPMPDMASAEEGAYDALERDQLKAALKGLQRRQREVLVLRYFVDMTEAQVAEALGISLGSVKAYGSRGLAALRIQMEAGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVZ8</accession>
    <name>A0A1E7MVZ8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553357.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000272.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3819"/>
    <dbReference type="EnsemblBacteria" id="ARF78359">
        <property type="protein sequence ID" value="ARF78359"/>
        <property type="gene ID" value="B6264_04985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32601">
        <property type="protein sequence ID" value="OEV32601"/>
        <property type="gene ID" value="HS99_0015095"/>
    </dbReference>
    <dbReference type="OMA" id="QLMVNSN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41455" checksum="6D1F60DFB3C39A78" modified="2017-01-18" version="1">MTRSALVGTAPARPLGAQRVRQLPAGGLVALLAGRGADSVDLAAGTPKWPATPPELVEGAVRALREGVHQYEDPAGNPRLREWIAGTLPGRPDPDTELTVTAGASEALAVALLACVDPGDEVVVLEPFYENFLSAVALVGGVPRFVRAEGPDWALDPDALTAAFGPRTRAIVLNSPANPTGRLLTDGELGLIAELCERWDVTAVSDEVYAGYVYDGARHRSVAELPGLAERSIVLGSFSKSHAVSGWRLGYLRAPAPWTRMLRQVHVATTGGAAAPLQHALAEAGPALRDGWDPAGSMRPLRDLAVRMLTEAGFDCVAPRGGIYVTAGIQHLTREPSPAFVRDLAAATGVLLAPATPFFADPRRGDRYVRVAFNRPEATLREAHRRLTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW19</accession>
    <name>A0A1E7MW19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553385.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000335.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3849"/>
    <dbReference type="EnsemblBacteria" id="ARF78331">
        <property type="protein sequence ID" value="ARF78331"/>
        <property type="gene ID" value="B6264_04835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32628">
        <property type="protein sequence ID" value="OEV32628"/>
        <property type="gene ID" value="HS99_0015245"/>
    </dbReference>
    <dbReference type="OMA" id="IYYKRQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32216" checksum="5C1A85F2786CBA1E" modified="2017-01-18" version="1">MIEIERLTKRYGATTAVDQLTFTVRPGTVTGFLGPNGAGKSTTLRMILGLNTPTEGSVTVDGVPFAGRPRGLRHVGALLDAGDVHGGRSAKAHLSALARSNRIPLGRVDEVLAEVGLGKAAGRRIGGYSLGMKQRLGIAGALLGDPPVLLFDEPLNGLDPEGVLWVRGLFRRLADEGRTVFVSSHMMAEMEHTADRLVVIGRGRLIADESLAEFSARNARSSVAVRAPELSLLVDALRAEGAEVDLMEPQFAIVTGMAAERIGELAHRHKVVLHELASRTSSLESAFMSLTADSIEYPAGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW74</accession>
    <name>A0A1E7MW74_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0015470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3157"/>
    <dbReference type="EnsemblBacteria" id="ARF78294">
        <property type="protein sequence ID" value="ARF78294"/>
        <property type="gene ID" value="B6264_04615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32669">
        <property type="protein sequence ID" value="OEV32669"/>
        <property type="gene ID" value="HS99_0015470"/>
    </dbReference>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="15161" checksum="10464AA5F28590CE" modified="2017-01-18" version="1">MSYEIQKTEAEWRAQLSPEEYHVLREAGTERPFVGEYTDTKTVGVYSCRACGAELFSSETKFDSHCGWPSYYAPLAEDRVEYIEDTSLGMRRVEVRCARCGGHLGHVFEGEGYGTPTDQRYCINSISLTLKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE9</accession>
    <name>A0A1E7MWE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554622.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000778.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6105"/>
    <dbReference type="EnsemblBacteria" id="ARF78190">
        <property type="protein sequence ID" value="ARF78190"/>
        <property type="gene ID" value="B6264_04010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32765">
        <property type="protein sequence ID" value="OEV32765"/>
        <property type="gene ID" value="HS99_0016070"/>
    </dbReference>
    <dbReference type="OMA" id="LYREAPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="43900" checksum="7A6FB82E5E5EE34E" modified="2017-01-18" version="1">MGRLAQTDGLTEIQRDILATVRDFVDKEIIPVATELEHKDEYPTAIVEGMKQLGLFGLTIPEEYGGLGESLLTYALVVEEIARGWMSVSGIVNTHFIVAHMINAHGTQEQKDYFLPKMAAGEIRGAFSMSEPGLGSDVSAISTKGVKDGEFYVLNGQKMWLTNGGTSTLVAVLCRTDEGGNTPYKNMTTFLIEKTAGFGPNPTVPGLTVPGKIEKMGYKGVDTTELVLQDVRIPADRILGGIPGRGFYQMMDGVEVGRVNVAARGCGVARRAFELGISYAQQRSTFGKKIAEHQAIQFKLAEMATKVEAAHQMMVMAARKKDSGERNDLEAGMAKYLASEYCKEVVEDAFRIHGGYGFSKEYEIERLYREAPMLLIGEGTAEIQKMIVGRRLLEEYKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF1</accession>
    <name>A0A1E7MWF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000786.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6114"/>
    <dbReference type="EnsemblBacteria" id="ARF78197">
        <property type="protein sequence ID" value="ARF78197"/>
        <property type="gene ID" value="B6264_04055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32758">
        <property type="protein sequence ID" value="OEV32758"/>
        <property type="gene ID" value="HS99_0016025"/>
    </dbReference>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="22392" checksum="7754B8C8B2110F56" modified="2017-01-18" version="1">MPKGVPESVPDDGLTTRQRRTQPITAVHTGPGKGKSTAAFGMALRAWNQGWSVGVFQFVKSAKWKVGEENALRVLGASGEGGSVDWHKMGSGWSWIQRSAEQEMTSEEAAKEGWEQVKRDLAAETYRFYVLDEFTYPMHWGWIDPEEVVSVLKDRPGSQHVVITGRYAPEALTGFADLVTEMTKVKHPMDAGRKGQRGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF5</accession>
    <name>A0A1E7MWF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366526.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6110"/>
    <dbReference type="EnsemblBacteria" id="ARF78193">
        <property type="protein sequence ID" value="ARF78193"/>
        <property type="gene ID" value="B6264_04035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32761">
        <property type="protein sequence ID" value="OEV32761"/>
        <property type="gene ID" value="HS99_0016045"/>
    </dbReference>
    <dbReference type="OMA" id="TRWQAYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25134" checksum="2F4C9EF05A1FFDFE" modified="2017-01-18" version="1">MRRRKSPTTAAPSPVPFSPEAARAHRAGLGLSPDQVAEGMAAHGVRLLPGHVLAWENGELRPGEAEFIALARALWCPAAQLMDGRPVSLRDHRLARELGQEAVAERTGVSLPAYRQAELTGHWDGDRDQTHALAQALGLRLTELVEATGRGEALDRLLRQCVAGRWQPHLRPLARLVPVPEADLAAVLPVLHQEHHVPSHWGATAQPRTATPPLVPRFWHLLSALDPAIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWL8</accession>
    <name>A0A1E7MWL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000083">
        <property type="protein sequence ID" value="OEV32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283940.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000530.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4123"/>
    <dbReference type="EnsemblBacteria" id="ARF80137">
        <property type="protein sequence ID" value="ARF80137"/>
        <property type="gene ID" value="B6264_15530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32835">
        <property type="protein sequence ID" value="OEV32835"/>
        <property type="gene ID" value="HS99_0039865"/>
    </dbReference>
    <dbReference type="OMA" id="CASMPDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="617" mass="64703" checksum="B592DDAB4B00844E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWU7</accession>
    <name>A0A1E7MWU7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0015750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290220.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000836.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7856"/>
    <dbReference type="EnsemblBacteria" id="ARF78247">
        <property type="protein sequence ID" value="ARF78247"/>
        <property type="gene ID" value="B6264_04335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32713">
        <property type="protein sequence ID" value="OEV32713"/>
        <property type="gene ID" value="HS99_0015750"/>
    </dbReference>
    <dbReference type="OMA" id="YPMIGSH"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="34061" checksum="78BEBC35E8EA6890" modified="2017-01-18" version="1">MLRSALLAASRSPQVRTVVEKFPPTHAIVERFVAGAVLDDAVTACDDLVATGRKVTLDHLGEDTKDAAQAAGTAEAYEHLLKALKETGLAAGAEVSVKLSAVGQFLPVDGEKIALENARRICEAAADAGTTVTLDMEDHTTTDSTLAIARELRADFPWLGIVLQAYLRRTEADCREFSGAGSRVRLCKGAYKEPESVAFQGKHEVDLAYVRALKVLMAGEGYPMIASHDPNMIKIAGQLAQWNNRTRDSFEYQMLYGIRPEEQLRLAGEGNTMRVYLPYGQEWYGYFMRRLAERPANLTFFLRAMATRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY3</accession>
    <name>A0A1E7MWY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552550.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81351">
        <property type="protein sequence ID" value="ARF81351"/>
        <property type="gene ID" value="B6264_22755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32941">
        <property type="protein sequence ID" value="OEV32941"/>
        <property type="gene ID" value="HS99_0013735"/>
    </dbReference>
    <dbReference type="OMA" id="DTANCIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="6914" checksum="32D35D01547E92DA" modified="2017-01-18" version="1">MADQSWQKSSFSGDTANCIYLAEASGDGIRIRESDAPGIIISTSLDVLRALLLGVKAGEFDHLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ9</accession>
    <name>A0A1E7MWZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6108"/>
    <dbReference type="EnsemblBacteria" id="OEV32763">
        <property type="protein sequence ID" value="OEV32763"/>
        <property type="gene ID" value="HS99_0016055"/>
    </dbReference>
    <dbReference type="OMA" id="AFQVHTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="44084" checksum="C0DB49953E006279" modified="2017-01-18" version="1">MLVDAVRIARWAGELEEVDKRGELLPEDARAAGRALAMTVGAAAKAWGQALLVGLVEARDGGAGPGWRLHAWEHDDEAVVRGWSGLFDAWTLLAPVPPAALRGVFAVLAGQAVDQAPQLLSFLHLVDGPVAESELLELLRRGLDERRVGAGLGNPGLSPVPHAASAVSAVRGTCRAPQIDTPAAPSDVAAVLDWMLDGLAAVGAVVRRNDAAELSPLGHWAVRAKLEEICTVAQTAAGHIEQSAFELLNACADYSPGPARAEFRAWVAARPADRAVAELLDAAQGDDALVRGLAFEALRVAGGPAEQAVRASVDEPVLRPYALLWLAERADEGVSPADVLGAEDAAWLWVDTAAAVLDHGETELLVGHVEGASAGDPVRLFARARQSGHPRAASVLTAVSGVHPDPGVARAARRSAFSVHTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXB2</accession>
    <name>A0A1E7MXB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0014505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279721.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5618"/>
    <dbReference type="EnsemblBacteria" id="OEV33072">
        <property type="protein sequence ID" value="OEV33072"/>
        <property type="gene ID" value="HS99_0014505"/>
    </dbReference>
    <dbReference type="OMA" id="FQWRWSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="VKc" evidence="11">
        <location>
            <begin position="12"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="22339" checksum="62F54BC23AF86FAC" modified="2017-01-18" version="1">MTAAAPRSIGASRPFAWLLLVGGVVGLFASTVLTLDKIRLLEDPSYVPGCNINPIISCGSIMRSDQASAFGFPNSLIGLVAFGVVVAIGAGLLAGASYRRWFWLGLQAGTAFGIGFVTWLMYQTLYRIGALCPYCMVVWAAMIPLFWYTTLHNLRSGVIPVGRRGRVAVREAARYHWVVPALWYAVIALLVLNRFWYFWSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXF2</accession>
    <name>A0A1E7MXF2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33109">
        <property type="protein sequence ID" value="OEV33109"/>
        <property type="gene ID" value="HS99_0014755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="11849" checksum="C708DCBD34A823C1" modified="2017-01-18" version="1">MPSLTERPSAALTPRWLERPSCLAISAARQARSGSVRMIWRVRSSAPAVPLDAGLTALAQVAAAQAALPLEDLCRTLADAHLGDGRDDIAVLALRTPPAGPTHGTPVTHSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH7</accession>
    <name>A0A1E7MXH7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283505.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000537.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2673"/>
    <dbReference type="EnsemblBacteria" id="OEV33136">
        <property type="protein sequence ID" value="OEV33136"/>
        <property type="gene ID" value="HS99_0014910"/>
    </dbReference>
    <dbReference type="OMA" id="QITFDCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="16010" checksum="F9A62CB4E9006B1E" modified="2017-01-18" version="1">MSTIRKFQVTFDCAEPERVGRFWCEVLGYVPPEPPNGFATWEDYENSRPPEERGSWFACSDPTGVGPRLYFQRVPEGKVAKNRVHLDVRVGTGLVGEERLAVLEAECERVLALGAVRVQLLYDGHDSCISMQDIEGNEFCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI4</accession>
    <name>A0A1E7MXI4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5670"/>
    <dbReference type="EnsemblBacteria" id="OEV33155">
        <property type="protein sequence ID" value="OEV33155"/>
        <property type="gene ID" value="HS99_0014250"/>
    </dbReference>
    <dbReference type="OMA" id="CDVSPKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024029">
        <property type="entry name" value="Pyridox_Oxase_FMN-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04025">
        <property type="entry name" value="PPOX_FMN_DR2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="37"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="23064" checksum="DF5C05EC2147A7D4" modified="2017-01-18" version="1">MFAALRAGALTDPAQLREVYEQPGDHARRKQVDRLHEVAQRLIACSSLVFVASSDAAGRCDVSPRGGPAGLVSVLDEYTLAIPDATGNKRLDTLHNILENGRVGLLFVVPGRDTTLRVNGRACVSTDPELLRQLTAVGKPPRSAIVVAVEEVYAHCPKSLLRASAWKPENWLAKDAQPSSAEVTLSHLRDDSLTVEMIEQAEREALLYRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI7</accession>
    <name>A0A1E7MXI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366938.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33124">
        <property type="protein sequence ID" value="OEV33124"/>
        <property type="gene ID" value="HS99_0014840"/>
    </dbReference>
    <dbReference type="OMA" id="GHINNAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="21223" checksum="5BFB1D62AEFCB911" modified="2017-01-18" version="1">MSALYPGVHVLSCPTRWSDVDENGHINNARLVGYIQEGIYDLFCHHATAVRESLFPSGFIIARHEIDYLEQLHHRPEPLSVRLTVERIGRSSAHVEVNVCREPLTFMRARTVVVARDRESGRSRKLSQSERRFLSAFMSDPAVGRVPDPTRRDTVVAVAQPMAPAQRTAARSGAGVGASRGSRRRVRASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ4</accession>
    <name>A0A1E7MXJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386225.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000267.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5605"/>
    <dbReference type="EnsemblBacteria" id="OEV33165">
        <property type="protein sequence ID" value="OEV33165"/>
        <property type="gene ID" value="HS99_0014570"/>
    </dbReference>
    <dbReference type="OMA" id="WIVHATD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="41395" checksum="23AC576C47575FAE" modified="2017-01-18" version="1">MLLAQGVDRTGSGVWAAASVLYFTYVCGMDAGRLGLLLGVGAVAGIVGSPLAGRAAERLPVRGLLIGCHLLRVATMGLLLVVDHFAALLLSVALTCLAERGAKTLEMLFATRIAGERRATYQALFRSVANGGYAVGTGFAAIGLAVGSTTAYRALIVANALSYLLAAALIRRTAEPAGRGLVAAVPSPAQEAAGGGPAAVPSPWRDRGYLLFVLLDLPMCLDDSVLNVGLPLWLIHHTGAPHAVVPAFLTVNTVLVVVLQLRVSAWAENPRGATTAVGWYGLTLLASCALIALSTGGGPLTASLVLLAAAALVTLAELMRSVSSWELAVSLAPPRAKASYLGVAGMSQSVQKSVGPMLLTGVVMAAGPAGWLALGAASTGLAAVQRRASLRRLAALEASAGASAAAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXP2</accession>
    <name>A0A1E7MXP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385421.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5698"/>
    <dbReference type="EnsemblBacteria" id="ARF81421">
        <property type="protein sequence ID" value="ARF81421"/>
        <property type="gene ID" value="B6264_23140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33003">
        <property type="protein sequence ID" value="OEV33003"/>
        <property type="gene ID" value="HS99_0014110"/>
    </dbReference>
    <dbReference type="OMA" id="ARHIDLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="22811" checksum="3F28A2A402CEF2FF" modified="2017-01-18" version="1">MLKVDPEHGPLVPMLLVLTVVTGVVDAVSYLALGHVFVANMTGNVVFLGFALAGAPGLSATASLAALAAFLLGALAGGHLSRHLPGHRGRLLTVAIAVQAVFVAVSVLLAAAVGHSSESARYTLIGLLALAMGGQNAVARSLKVPDLPTTVLTMTLTALAADLTGSRRLASAVWMFAGALLGALLVLHASVPVALALAFALLVAVAALTHHAARPNPAPAWTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR9</accession>
    <name>A0A1E7MXR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Riboflavin synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552444.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5667"/>
    <dbReference type="EnsemblBacteria" id="ARF81450">
        <property type="protein sequence ID" value="ARF81450"/>
        <property type="gene ID" value="B6264_23295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33033">
        <property type="protein sequence ID" value="OEV33033"/>
        <property type="gene ID" value="HS99_0014265"/>
    </dbReference>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="25154" checksum="BFD74C5F7C15BE43" modified="2017-01-18" version="1">MFTGIIEELGEVVSIEEIGDSSRIRLRGPVVRDGARHGDSIAVNGVCLTVVDTPEQLAAETGEFSADVMAETLHRSSLGELKPGSPINLERAMALGARLGGHLVQGHVDATGRLLSREPGERDADGNLRWEVLRFSLPESISRYLVEKGSITVDGVSLTVVEAARDSFTVSLIPATLALTTLGAKALGESVNLEVDVLAKYVERLLESRTLPNLPNIPNLPNIPDLPVSDSTGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB3</accession>
    <name>A0A1E7MYB3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="9" type="ORF">HS99_0012570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287573.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3976"/>
    <dbReference type="EnsemblBacteria" id="ARF80513">
        <property type="protein sequence ID" value="ARF80513"/>
        <property type="gene ID" value="B6264_17795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33409">
        <property type="protein sequence ID" value="OEV33409"/>
        <property type="gene ID" value="HS99_0012570"/>
    </dbReference>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="35820" checksum="2C21083F095F26E9" modified="2017-01-18" version="1">MTKPQIRPATGAQYSRIHGVGGYRPVRVIPNSEVLEWIDSSDEWIRTRSGIAERRWAGPEESVAEMSVQAAGKAIAQAGITPEQIGGVIVSTVSHLKQTPAIATEIAQRLGCGTAPAFDISAACAGFGYGLGLADGMVRGGNAEYVLVIGVERLSDLTDKSDRSTAFIFGDGAGAAIVGPSNTPGIGKLIWGSDGSQADVISQTQAWDTAFAKPDAINGQGEEQKWPALRMDGQPVFRWAVWEMAKVAQQALDAAGITADQLGAFIPHQANMRITDAMIKALKLPASVPVARDIAETGNTSAASIPLAMERMLESGEAHSGDLALIIGFGAGLVYAAAVVTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE8</accession>
    <name>A0A1E7MYE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0012760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288763.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6576"/>
    <dbReference type="EnsemblBacteria" id="ARF80545">
        <property type="protein sequence ID" value="ARF80545"/>
        <property type="gene ID" value="B6264_17985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33441">
        <property type="protein sequence ID" value="OEV33441"/>
        <property type="gene ID" value="HS99_0012760"/>
    </dbReference>
    <dbReference type="OMA" id="FTHMSAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27088" checksum="914BD3332EC3895A" modified="2017-01-18" version="1">MVTTSSATRELALLHARELLRDRRYFYFALFFPFGMTGIFLTIGAIAPKSSGTPDFMQLVIPMALFLAVTSTALTVTTGPLANLRSKGTLRLLGTTPVGRARLVFTHMSARIVMVVCQALALLVLAYAMGKVEASRLPALFGITLLGLAMFGGIGYLIGGRLSSPDAATNVGTLVQLLSLFLSGLAFPLHLMPAALAKTLSVLPTTCFADLMTTQMSAGEPYHPAWLSASVVAVTAVAVTFLAVRTFRWDQGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYF5</accession>
    <name>A0A1E7MYF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555556.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80578">
        <property type="protein sequence ID" value="ARF80578"/>
        <property type="gene ID" value="B6264_18180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33475">
        <property type="protein sequence ID" value="OEV33475"/>
        <property type="gene ID" value="HS99_0012960"/>
    </dbReference>
    <dbReference type="OMA" id="SHRGDDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="18366" checksum="6522B5BC1C7CB1D8" modified="2017-01-18" version="1">MPNERHILLLPGSLRAGSVNEAVLRTAAAVADELPGVRTTYYTGLAGLPHFNPDHDTDPLPQPVAALRAAIEAADALLFCTPEYAGTLPGAFKNLLDWTVGGVEISDRPAAWINCAAPGRGQGAEATLGTVLGYTGAAVLADACARIPLERGAVGPDGLVADPLVRGRIGEVLARLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ6</accession>
    <name>A0A1E7MYJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348211.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000357.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5183"/>
    <dbReference type="EnsemblBacteria" id="OEV33507">
        <property type="protein sequence ID" value="OEV33507"/>
        <property type="gene ID" value="HS99_0013175"/>
    </dbReference>
    <dbReference type="OMA" id="PPKWYEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7976" checksum="C73572E4FECD5019" modified="2017-01-18" version="1">MKSADTEFVGGPLDGKVLPIPLGPMLGVPKKYKVPVPAHDDSPARTLVYVRSKQVRGLSWFWRYEYDEAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYL8</accession>
    <name>A0A1E7MYL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent F420 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282546.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5189"/>
    <dbReference type="EnsemblBacteria" id="ARF80614">
        <property type="protein sequence ID" value="ARF80614"/>
        <property type="gene ID" value="B6264_18425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33511">
        <property type="protein sequence ID" value="OEV33511"/>
        <property type="gene ID" value="HS99_0013205"/>
    </dbReference>
    <dbReference type="OMA" id="IDTDVMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="23935" checksum="CC44EDBFD5AF1D5D" modified="2017-01-18" version="1">MTSLDSATNPAHELPDVSQLVVGVLGGTGDQGRGLALRLAKAGQQVIIGSRDGARAEASAAELGVGVRGADNATVARESDVVIVAVPWEGHAATLTALREELAGKIVVDCVNPLGFDKQGAYALKPEEGSAAQQAAALLPDSRVTAAFHHLSAVLLQDESVERIDTDVMVLGDDRAATDVVRALAGLIPGMRGIYSGRLRNAHQVEALVANLISVNRRYKAHAGLRITDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD6</accession>
    <name>A0A1E7MZD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283708.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000580.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80374">
        <property type="protein sequence ID" value="ARF80374"/>
        <property type="gene ID" value="B6264_16975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33796">
        <property type="protein sequence ID" value="OEV33796"/>
        <property type="gene ID" value="HS99_0037605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="7506" checksum="7BE121E613548277" modified="2017-01-18" version="1">MSEPSDTPQAPSHPTGSAVGDSAGPATPKTLLEQMQELLASVTADLAALQSGARTAPAAAYPAGTDTSDAPTAAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF7</accession>
    <name>A0A1E7MZF7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clpX</name>
        <name evidence="8" type="ORF">HS99_0037740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283761.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000513.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4496"/>
    <dbReference type="EnsemblBacteria" id="ARF80398">
        <property type="protein sequence ID" value="ARF80398"/>
        <property type="gene ID" value="B6264_17115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33818">
        <property type="protein sequence ID" value="OEV33818"/>
        <property type="gene ID" value="HS99_0037740"/>
    </dbReference>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="47000" checksum="16DA8C7FCA59D47E" modified="2017-01-18" version="1">MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAETSEVRFEELPKPREIYEFLDQYVVGQDLAKKALSVAVYNHYKRVQAGEAGRSGGNGREDAIELAKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLERIIEGRAGAKGIGFGANIRSKRESDASDHFRQVMPEDLVKFGMIPEFIGRLPVITSVHNLDREALLQILTEPKNALVKQYRKLFELDGVELEFSRDALEAIADQAILRGTGARGLRAIMEEVLMSVMYEVPSRQDVARVVVTGDVVSKHAIPTLVPRDMIKRERRDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR3</accession>
    <name>A0A1E7MZR3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283109.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1858"/>
    <dbReference type="EnsemblBacteria" id="ARF77765">
        <property type="protein sequence ID" value="ARF77765"/>
        <property type="gene ID" value="B6264_01440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33922">
        <property type="protein sequence ID" value="OEV33922"/>
        <property type="gene ID" value="HS99_0010600"/>
    </dbReference>
    <dbReference type="OMA" id="FVAGPTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="34898" checksum="073692391D3CB2D9" modified="2017-01-18" version="1">MNRRLPVAVLAVTLSATLLAACGSSGDTSTSGGGSASSAAPSGTAAGFPRSVKHAAGTAQIKSQPKRVVVLDSGELDDVTLLGITPVGAVSPHMKTEGGFPNYLKDRIKDTKDVGPMNEPNLELIASLKPDLILSSKVRHAKVYDQLNAIAPTVLAETTGFPWKENLALYAQALGKEDEAKKALADYEERAHKLGEAIKAKYNGKMPTASVVRFVAGPTRLYAKASYSGVVLKDVGLARPTSQDVDKNIIEVSAEQINQADADLVFVTTADDPSKTKESEVQQTPVWQGLNAVKDSKVFTVPDETWMSGIGVQAADAMLVDIAKAAGVDAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N033</accession>
    <name>A0A1E7N033_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551824.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2300"/>
    <dbReference type="EnsemblBacteria" id="ARF77906">
        <property type="protein sequence ID" value="ARF77906"/>
        <property type="gene ID" value="B6264_02300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34049">
        <property type="protein sequence ID" value="OEV34049"/>
        <property type="gene ID" value="HS99_0011450"/>
    </dbReference>
    <dbReference type="OMA" id="DDYHAYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="44908" checksum="BF755D5FCD0EBD3F" modified="2017-01-18" version="1">MGKTNGGFSETGLRRMRDVLTRHVDSGRIPGVVALVSRGDETYVEALGTMGHDGGAPMRRDTIFRMASTSKPVSVAAAMVLLDECRLRLDDLVEQWLPELADRRVLKRIDGPLDDTVPAKRPITVRDVLTSTFGLGMDLTSLGTPIMNSVFEQGLTPDLPTPMPEPDEWIRRLGTLPLMHQPGEQWQYHIASDLLGVLVARVTGQPFESFLHERIFDPLGMEDTGFHVPAGKIDRLPPLYAPDPRTGAFTVWDEPADGRWSKPPAFPGGGGGLVSTVDDYHAYFRMLLDHGVHEGERILSRPAVRLMTTNRMTPEQTAVRRALAADNVHISYGQGQHGGWGFGMAVRTYRGDYAPVGQFGWDGGSGTSTYADPENGLVGIVLTQVGMSVPHSARLIHDFWTTVYQAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N071</accession>
    <name>A0A1E7N071_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366486.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77958">
        <property type="protein sequence ID" value="ARF77958"/>
        <property type="gene ID" value="B6264_02580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34097">
        <property type="protein sequence ID" value="OEV34097"/>
        <property type="gene ID" value="HS99_0011725"/>
    </dbReference>
    <dbReference type="OMA" id="GLTMTQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="12100" checksum="1F09696CFF02DFA3" modified="2017-01-18" version="1">MPQYVTLLVLQQSSGMSGAQLARECMVTPQTMTTILTNLENKGLITRETSSVHQKVLVAKLTRTGRALAKKADTLARGVEQRLADAFDDTEQAQLRELLERSAAALRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H6</accession>
    <name>A0A1E7N0H6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sigma70_r2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0011715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551888.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2354"/>
    <dbReference type="EnsemblBacteria" id="OEV34176">
        <property type="protein sequence ID" value="OEV34176"/>
        <property type="gene ID" value="HS99_0011715"/>
    </dbReference>
    <dbReference type="OMA" id="HERQAGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="30126" checksum="ADD61E29B16D7BFB" modified="2017-01-18" version="1">MPDHERQAGQFEHLRPRMRALAYPLLGSFDEAEEAVREAWVRLGRINPEEVADLSAWLAVVTGRVCLGLLDARTGRPRLRLPDVVVEPERSGGESQAAPVGLTLFVALDGLAPAERVAFVLHDLVRLHVDQVATVLERTTADTRKLAEQARRRVRAAREADGDDRPAARRRLVDAFCAAVLDGDPAALAAVLEPEAELRADGWHPLRGAHEVAERTVALCQGGGPAFTPVLVDGSPGALVTRDGVPAAVLGFAVRAGRISRVHLLLAPERLAALDADALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0I3</accession>
    <name>A0A1E7N0I3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0011900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3717"/>
    <dbReference type="EnsemblBacteria" id="OEV34181">
        <property type="protein sequence ID" value="OEV34181"/>
        <property type="gene ID" value="HS99_0011900"/>
    </dbReference>
    <dbReference type="OMA" id="STMIIEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="7677" checksum="6E5FCD50C49D5329" modified="2017-01-18" version="1">MIIEILTTKYEVPAEDVSPEVAFDELAVDSLTLLEMSLILEKRLGIAIQEGALEAGQTVGEAAEMISSLGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T3</accession>
    <name>A0A1E7N0T3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550798.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2584"/>
    <dbReference type="EnsemblBacteria" id="OEV34281">
        <property type="protein sequence ID" value="OEV34281"/>
        <property type="gene ID" value="HS99_0036770"/>
    </dbReference>
    <dbReference type="OMA" id="PQFDWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="35809" checksum="0161F97A8C5C757C" modified="2017-01-18" version="1">MTQTVVITGASAGIGRATARLFGRRGANVVLLARGSAGLEAAAAEVERAGGTALALPTDVADHQAVSDAADRAEERFGAINVWINVAFTSVFAPFDEIRPEEFRRVTEVTYLGFVYGTMAALERMKPRNRGTIVQVGSALGARAIPLQSAYCGAKHAVNGFTESVRCELLHEGSEVRVTVVQMPAANTPQFSWVLSRLPRHPQPVPPIYQPEVCARAVAYAADHPRRKQYWVGASTAATILAQKAAAPLLDRYLARTGYDSQQTGDSVTPGRPNNLWHPVDGADGTDHGAHGEFDERSHSRSFQLWASQHTGTVCAVAGGLLAAGVSVAFARNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N178</accession>
    <name>A0A1E7N178_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290667.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1068"/>
    <dbReference type="EnsemblBacteria" id="ARF78955">
        <property type="protein sequence ID" value="ARF78955"/>
        <property type="gene ID" value="B6264_08515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34447">
        <property type="protein sequence ID" value="OEV34447"/>
        <property type="gene ID" value="HS99_0035680"/>
    </dbReference>
    <dbReference type="OMA" id="GDMGRQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="44984" checksum="1C34247ED6E0A7DD" modified="2017-01-18" version="1">MSKSPGERVPVRSFWWWKRRRSALLDIGLALLAAVECSAGTIAFLSARIHVSLAGAVGIAVLGTLAGGSLVVRRRWPAVPVLATLLVTPGMLGVLLLVVSLYTLAETWEWPSRRRRVVALSGLAFAEAAAVIAVTLIVPGDSSVEQPPLWIQILFSLLVAVGLTVAPVVTGLYVGARRRLIESLKDRAHGLETELDLLAEQAQERARRARLEERTRIAREMHDVVAHRVSLMVVHAGALERIAVKDPEKAAQSAKLMGEVGRQALNELREILGVLRMDDERQPEPDSLAGLPRLVDQSRAAGMAVTLTVSGSRQDFTGDAEQTAYRVVQEGLTNAHKHAGGAQVSVLLAYAPNGVRVSVVNACPGGERGAAQLPSGGNGLVGMRERVIALGGTFSSGPEADGGFRVEAVLPSRLAVRSDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1E9</accession>
    <name>A0A1E7N1E9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386031.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1898"/>
    <dbReference type="EnsemblBacteria" id="ARF78498">
        <property type="protein sequence ID" value="ARF78498"/>
        <property type="gene ID" value="B6264_05835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34293">
        <property type="protein sequence ID" value="OEV34293"/>
        <property type="gene ID" value="HS99_0036545"/>
    </dbReference>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="15723" checksum="944EA5157295A612" modified="2017-01-18" version="1">MTDHELAERVHAALRAEGGTLAVAESLTGGLLAAALVDVPGASATFRGSVTAYATELKASVLGVDEGLLDVYGPVHPVVARQMAEGVRALLGATYGLATTGVAGPDPQDGQPVGTVHLAVAGPGGTLVSSPLLSGARATIRHDAVTAALELLAGRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1K5</accession>
    <name>A0A1E7N1K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558232.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77529">
        <property type="protein sequence ID" value="ARF77529"/>
        <property type="gene ID" value="B6264_00045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34580">
        <property type="protein sequence ID" value="OEV34580"/>
        <property type="gene ID" value="HS99_0008745"/>
    </dbReference>
    <dbReference type="OMA" id="RQEYAAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15374" checksum="2121515747462F74" modified="2017-01-18" version="1">MIGHDPRAGARSEAPLPESAYAAALGPAAENTAVTRLQTALRHSGQYPRASLEREFRLRRAALADRLALESGEECDAAEAARTAYELVAFDLADGRFVLGPAGPGSSRWEESARPYVRQEYERWAELTDGGRDARLKDTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1R0</accession>
    <name>A0A1E7N1R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554735.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000470.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4269"/>
    <dbReference type="EnsemblBacteria" id="ARF82006">
        <property type="protein sequence ID" value="ARF82006"/>
        <property type="gene ID" value="B6264_26765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34629">
        <property type="protein sequence ID" value="OEV34629"/>
        <property type="gene ID" value="HS99_0009025"/>
    </dbReference>
    <dbReference type="OMA" id="DTARYPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16804" checksum="5CE583B1A45121BB" modified="2017-01-18" version="1">MPTAATDMTDEQRKAFVTAYLKAFDNGGTGHDGTPVLDFFAEDADFFFPKWGLAHGKPEIAKMFGDLGGSITSVRHHTWAFTWVLSGTDLLAVEGTTHGEHRDGPWRVGQPEWGAGRFCGVFEVRDHLIHRAFIYLDPDYAGGDTARYPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z3</accession>
    <name>A0A1E7N1Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555950.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4658"/>
    <dbReference type="EnsemblBacteria" id="ARF81932">
        <property type="protein sequence ID" value="ARF81932"/>
        <property type="gene ID" value="B6264_26330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34704">
        <property type="protein sequence ID" value="OEV34704"/>
        <property type="gene ID" value="HS99_0009450"/>
    </dbReference>
    <dbReference type="OMA" id="ATRIYED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15859" checksum="8085F381CEF5C352" modified="2017-01-18" version="1">MDISSSHRAIENLIAAYAVHVDSGDFGAVGALLADALFVGSGAPVRGREAVEAMFQDTLITYDDGTPRTKHVTTSTVIDIAADSTHATARSYFTVLQALPDLPLQPIAAGRYQDRFEYRGQRWHFTERHVHVDLVGNMTHHLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A6</accession>
    <name>A0A1E7N2A6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557758.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7619"/>
    <dbReference type="EnsemblBacteria" id="ARF81798">
        <property type="protein sequence ID" value="ARF81798"/>
        <property type="gene ID" value="B6264_25460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34840">
        <property type="protein sequence ID" value="OEV34840"/>
        <property type="gene ID" value="HS99_0010260"/>
    </dbReference>
    <dbReference type="OMA" id="RYSTREF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27269" checksum="9EC4CDBB6053648D" modified="2017-01-18" version="1">MSLTSVAARTAVRATGVTKVYGAEKPGTTAAVGVQALRGVDLAIDKGSFLAVMGPSGSGKSTLMHCLAGLDRPSSGTIILEDTEITALSERQRTDLRRDRIGFVFQQYHLLPELNGSENILLPLDIAGRRPDQDWLDTLVSALQIGDQLSRRPSELSGGQQQRIGIARALAARPAVVFADEPTGNLDAGSGRHVLEFLRYSTREFGQTVVMVTHDPVAASYSDRVVLLLDGRISGRVDGPTPESVLDALQNPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J6</accession>
    <name>A0A1E7N2J6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5874"/>
    <dbReference type="EnsemblBacteria" id="OEV34918">
        <property type="protein sequence ID" value="OEV34918"/>
        <property type="gene ID" value="HS99_0034985"/>
    </dbReference>
    <dbReference type="OMA" id="HAPAPYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="26237" checksum="66DA95DB661692DA" modified="2017-01-18" version="1">MTSPRSYDGVGYPSPSFSSGTPIYDSLVAERGVPQIAPINVPAALPPALSSGYGSGLGQSYENRYGNGYESAGSNLPALPPARLALGPGPSSGPSAGPATAYIPAQSAPAYASAPQPTVPAYGAPQPYQRPQPAAPAFAQTASGGYQPTGGQSFGGQNTFIGQGGQQTFGAQPTGGPAGFGQGQPGGLPQGGPQSFGGQQSFGGPNPAGPGFQGQGGDQGFGGAQLRPAMAPVAPVRPMQPQRPGPYGEPGGFQQGGYQQQGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B6</accession>
    <name>A0A1E7N3B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285483.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4485"/>
    <dbReference type="EnsemblBacteria" id="OEV35191">
        <property type="protein sequence ID" value="OEV35191"/>
        <property type="gene ID" value="HS99_0033920"/>
    </dbReference>
    <dbReference type="OMA" id="DHFIDNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20486" checksum="9EAC7833D1ED8B7D" modified="2017-01-18" version="1">MPPTPTTPPPDAVIPERHPQAPAPGTRLGSHYEHCFGCGPQHPGGLRIDAVAGEGLDVTAELTVRDVHQGGPGLAHGGLLTTAMDETLGTLNWLLHAPAVTGRLETDFLSPVPVDSVLHLRAWITGVHGRKIYSAAEARIGGPDGPVAVRAQALFVQVKLEHFTTHGRPEDIEKVLDDPDLMKRARAFEVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3G9</accession>
    <name>A0A1E7N3G9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79304">
        <property type="protein sequence ID" value="ARF79304"/>
        <property type="gene ID" value="B6264_10590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35241">
        <property type="protein sequence ID" value="OEV35241"/>
        <property type="gene ID" value="HS99_0033555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9553" checksum="B29496F490F671FB" modified="2017-01-18" version="1">MQLAAEEFERDARSALPVEQGVGHHLGEDEARRVRVQAHGMEQVPEESADRPDHPGKGRRGQVEPELGGERAPGGTEPWKAHGFLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L7</accession>
    <name>A0A1E7N3L7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282805.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5305"/>
    <dbReference type="EnsemblBacteria" id="OEV35291">
        <property type="protein sequence ID" value="OEV35291"/>
        <property type="gene ID" value="HS99_0033060"/>
    </dbReference>
    <dbReference type="OMA" id="FDAEQPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="40577" checksum="EC1E35705BB001B5" modified="2017-01-18" version="1">MHRTLIVTNDFPPRPGGIQAFVHNMAVRQPAGSVVVYASTWRDGTEVRRFDAEQPFPVIRDRTKVMVPTPRVTRRAAEILRAEKCESVWFGAAAPLGLMAPALRRAGAGRLLGMTHGHEAAWAQLPGSRQLLRRIGAGTDVLTYLGEYTRSRIAAAVGPRAAGRMVQLPPGVDESTFHPASGGAEVRRRLGLADRPVVVCVSRLVPRKGQDTLIEAMPQILADVPDAVLLIVGGGPYRADLEKLADARGVRASVRFTGSVPWEELPAHYGAGDVFAMPCRTRRGGLDVEGLGIVYLEASATGLPVVAGDSGGAPDAVLEGETGYVVPGGSAEAAAERIVRLLGDEELRRRMGEAGRRWVERSWRWDLLAGRLTSLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3S0</accession>
    <name>A0A1E7N3S0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278713.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2429"/>
    <dbReference type="EnsemblBacteria" id="OEV35349">
        <property type="protein sequence ID" value="OEV35349"/>
        <property type="gene ID" value="HS99_0032550"/>
    </dbReference>
    <dbReference type="OMA" id="VDWRIRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="30733" checksum="C7920B6EDF32D8E6" modified="2017-01-18" version="1">MRKVSFAEFGGPDVLQLIDAEEPHAGPGRIRIAVRAAGVNPVDWRIREGQKLGAHPTELPSGVGLDAAGVVDEVGEGVEGVEVGDRVFGEGACTYAEFTVLSAWARMPEGLSFEEAAGYPSVVETALRIIREVGVQPGQTLLVSGASGGVGSAVLQIARDRGITVIGTAGAANQDYLRGLGALPTTYGEGWVDRVRQLGRIDAALDLAGSGVIRELVELTGDPQKVITIADLGAPDLGVRFSGVAGSVPAALSVAADLISRGRLHIPVERTYTLAEAAAAHVDSQAGHARGRRVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D0</accession>
    <name>A0A1E7N4D0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5534"/>
    <dbReference type="EnsemblBacteria" id="OEV35547">
        <property type="protein sequence ID" value="OEV35547"/>
        <property type="gene ID" value="HS99_0031795"/>
    </dbReference>
    <dbReference type="OMA" id="WIDGSVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="185"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="445"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="58798" checksum="AC354211324AA734" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H9</accession>
    <name>A0A1E7N4H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387713.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000393.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5362"/>
    <dbReference type="EnsemblBacteria" id="ARF80764">
        <property type="protein sequence ID" value="ARF80764"/>
        <property type="gene ID" value="B6264_19285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35572">
        <property type="protein sequence ID" value="OEV35572"/>
        <property type="gene ID" value="HS99_0006520"/>
    </dbReference>
    <dbReference type="OMA" id="WIAGGHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="673"/>
            <end position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="939" mass="97273" checksum="BACFF0CA1C1A646B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P4</accession>
    <name>A0A1E7N4P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551152.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene910"/>
    <dbReference type="EnsemblBacteria" id="ARF80861">
        <property type="protein sequence ID" value="ARF80861"/>
        <property type="gene ID" value="B6264_19850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35667">
        <property type="protein sequence ID" value="OEV35667"/>
        <property type="gene ID" value="HS99_0007080"/>
    </dbReference>
    <dbReference type="OMA" id="MVHAVNS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="25158" checksum="F470D01BACF74760" modified="2017-01-18" version="1">MTTKTETAAPARFEDLQPLMALMTGDEKHDVAATSTLDALWVLYDRVLRVTPDTAEEQDRDRFLLSKGHGPMAYYAVLAAKGFIDPAVLPSFGGYDSPLGYHPDRTLLPGVEISSGSLGHGLPLAVGTALGLRAQGLTDPAVWVLLGDAEFDEGSNHEAMAFAGAYGLDRLHAVVIDNSSATHGWQGGIAQRFAAEGWSTATVDGRDHEALHRAYTTAHPGRPHVVVARVEPKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P5</accession>
    <name>A0A1E7N4P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385622.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene958"/>
    <dbReference type="EnsemblBacteria" id="ARF82936">
        <property type="protein sequence ID" value="ARF82936"/>
        <property type="gene ID" value="B6264_19610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35624">
        <property type="protein sequence ID" value="OEV35624"/>
        <property type="gene ID" value="HS99_0006840"/>
    </dbReference>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="29255" checksum="78AE8FC5040AC042" modified="2017-01-18" version="1">MTTTTAPLLDVTGVTMRFGGLTAVNDVSLTVGEGEIIGLIGPNGAGKTTFFNCLTGLYVPTEGAVRYRGTVLPPKPHLVTQAGIARTFQNIRLFANMTVLENVLVGRHTRTREGIFSAILRLPRYHHAEAESREKAMELLAFTGLAHKADHLARNLPYGEQRKLEIARALASDPGLLLLDEPTAGMNPQETRAAEELVFAIRDQGVSVLVIEHDMRFIFNLCDRTAVLVQGQKIVEGDRATVQNDERVISAYLGAPLESTTPAAPEDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W1</accession>
    <name>A0A1E7N4W1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene829"/>
    <dbReference type="EnsemblBacteria" id="OEV35729">
        <property type="protein sequence ID" value="OEV35729"/>
        <property type="gene ID" value="HS99_0007495"/>
    </dbReference>
    <dbReference type="OMA" id="NDAGFEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198760" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="45"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32404" checksum="EE03A8FE5CDEDAF1" modified="2017-01-18" version="1">MLRPARNSRRLRNSSVLAAVAVGAALALTSTTAQAAIPAPKHYVALGDSYAAGAGVPGQSAGLCLRSDHNYGHLVAASLEAGAYTDVTCAAAKVKAMTQPQYDAFIRVNDPQLDSVTADTDLVTLGIGGNDLAASDLGLGELVATCIAGATVNPLGTPCKDVYHHGYWDWNTWSWQYGNDDLAERVTTTIAPQIATTLQQIHAKAPGARVLLVGYPSVLPADGSACILRQPVTPGDVEYMYGVLNKLNAALKSTAAANGATYVDTATPTRGHDVCSDDRWIEGALPGSPAVPFHPNATGEQVMANAVLAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W8</accession>
    <name>A0A1E7N4W8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene818"/>
    <dbReference type="EnsemblBacteria" id="ARF80940">
        <property type="protein sequence ID" value="ARF80940"/>
        <property type="gene ID" value="B6264_20320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35736">
        <property type="protein sequence ID" value="OEV35736"/>
        <property type="gene ID" value="HS99_0007550"/>
    </dbReference>
    <dbReference type="OMA" id="DPWRYLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="26895" checksum="EEDFA1905DDF0C96" modified="2017-01-18" version="1">MSTRHIEFEALHNFRDLGGCSAADGRTVRRGLLYRSDSLGKSSPADLEKLRALGVRTVIDLRYDWEIAAKGRVPDFDGLDFHNLSIEHRPYDQASIDPELDPWRYLADRFAEVAEDGVKEIRRTLEVISAAEAPVVFHCMSGKDRTGLIAALVLTLLGVSEDDIAADFALTEHATAHLVADWHAAHPGETLRWPGYGRAPETVIRLALADLATRYGSVEAYVTGTVGLDRDRIDALRSRMLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N527</accession>
    <name>A0A1E7N527_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0007910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281432.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene747"/>
    <dbReference type="EnsemblBacteria" id="ARF81000">
        <property type="protein sequence ID" value="ARF81000"/>
        <property type="gene ID" value="B6264_20685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35789">
        <property type="protein sequence ID" value="OEV35789"/>
        <property type="gene ID" value="HS99_0007910"/>
    </dbReference>
    <dbReference type="OMA" id="RTEHFAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="28404" checksum="FEFA46CA8901C064" modified="2017-01-18" version="1">MSAAAPERMPALYLSHGAPPLADDPIWPGELSAWSADLPRPKAVLMVSAHWEEAPLAVGAVTTVPLVYDFWGFPEHYYTVRYPAPGAPELAERVRKLLRAPGTPVQDIPGRGLDHGAYVPLVEMFPEADIPVLQISMPTLDPQRLLEIGRRLAPLRDEGVLIIGSGFFTHNLRALSSDGRISSVMAEFDDWGRRALDAHDLDALLDFEHKAPAGRLAHPRTEHFAPLFVTLGAGEADLGSQRSVIDGFWMGLAKRSIQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y6</accession>
    <name>A0A1E7N5Y6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0031010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4978"/>
    <dbReference type="EnsemblBacteria" id="ARF80046">
        <property type="protein sequence ID" value="ARF80046"/>
        <property type="gene ID" value="B6264_14990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36101">
        <property type="protein sequence ID" value="OEV36101"/>
        <property type="gene ID" value="HS99_0031010"/>
    </dbReference>
    <dbReference type="OMA" id="RRFVADM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="513" mass="55092" checksum="8BA0C8E263C9658C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N672</accession>
    <name>A0A1E7N672_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8088"/>
    <dbReference type="EnsemblBacteria" id="OEV36190">
        <property type="protein sequence ID" value="OEV36190"/>
        <property type="gene ID" value="HS99_0030560"/>
    </dbReference>
    <dbReference type="OMA" id="HDASEGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5667" evidence="3">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="431" mass="43112" checksum="EB2453990EC243E0" modified="2017-01-18" version="1">MTANVLEHRRAKAFAEALEAHQAEQRRAANAESANAASTEAGSVAMAELVGLADALGALPGPALDREVRTVQRAQLMAAFEQAFAGGPGAAVPRQRRHRTIRTAPRGRWSRRFAIGGLVAGLAVGSLAGAAAASSSALPGDTLYGMKRGLEGLRLDLADSDSERGRLLLDNAATRLGEANALVGQPGSATALSPATVDRVRRALDDMHADALRGRDLLRSVYRSNGSLEPMRALAGFAHDEDGRWSELQGRLPVQLTQQAHLVDQLFDAISEDVAPLRLAQPPAKSGDPAGTGAGDDSSSSPGGSPDGSGTNGTGAAPGSGQSQGSAGNRPGTDHAPAATGTGSTAGNGKGAGLPSTLPSNAPDAVNGLVGGLTSGLSGAGKPSPSTDAAPPQVPQPPSGPASAPTGAQQGVDVPPLIPGLLPGLRILGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N686</accession>
    <name>A0A1E7N686_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8089"/>
    <dbReference type="EnsemblBacteria" id="ARF79803">
        <property type="protein sequence ID" value="ARF79803"/>
        <property type="gene ID" value="B6264_13610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36189">
        <property type="protein sequence ID" value="OEV36189"/>
        <property type="gene ID" value="HS99_0030555"/>
    </dbReference>
    <dbReference type="OMA" id="PIPTDGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="36398" checksum="205109200EBC5AA4" modified="2017-01-18" version="1">MSAAAENAPGEAKVIPIESAPSWSSPEGPGLADRLAGAVGGALSGQLGPAATRLFGKGWEARATEGLAFLRRRITGDYEVDEFGFDRELTEEVLLSLLRPLAEKYFRIEVQGIENIPAEGGALVVANHSGTLPLDALMTQVVIHDHHPHHRHLRMLAADLVFVLPGVNEVARKAGHTLACNEDAQALLERGEVVGVWPEGFKGIGKPFSERYKLQRFGRGGFVSSALRAKVPIVPCSIVGAEETYPMIGNVKTLARLLGLPYVPITPTFPWLGPLGMLPLPTKWTIRFGEPIATDGYPAEAADDPMLVFDLADEVRETIQHTLYQLLVQRRSVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6B3</accession>
    <name>A0A1E7N6B3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000574.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8042"/>
    <dbReference type="EnsemblBacteria" id="ARF79843">
        <property type="protein sequence ID" value="ARF79843"/>
        <property type="gene ID" value="B6264_13845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36231">
        <property type="protein sequence ID" value="OEV36231"/>
        <property type="gene ID" value="HS99_0030790"/>
    </dbReference>
    <dbReference type="OMA" id="MGKAVCF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="25561" checksum="7D740463BF6A69D7" modified="2017-01-18" version="1">MAATLVDLTHQVTTAMPVYPGDPAVLLEPALTTATAGVNVLALHLGSQSGTHVDAPYHVDVTWPTLDGLPLERFTGPAVVADLRGLEPRTAVTPELLAPALERCGEGSVLLLATGWARHWGTDAYLAHPSLTPAAAEAIVAAGVRTVGVDALSVDPTPDPGPDDRAVAALLADLTDEHDGPDPAVEESTLAAHRVLLGAEGGGVIAENLTDLRALLEAQEAGRPVEVSLFPLRLVAADGAPVRAVARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E2</accession>
    <name>A0A1E7N6E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-5'-phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550878.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000349.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2644"/>
    <dbReference type="EnsemblBacteria" id="OEV36276">
        <property type="protein sequence ID" value="OEV36276"/>
        <property type="gene ID" value="HS99_0030170"/>
    </dbReference>
    <dbReference type="OMA" id="LIDEVHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="450"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="752" mass="79396" checksum="B1F72D56EC71B797" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6K3</accession>
    <name>A0A1E7N6K3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387255.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000773.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4895"/>
    <dbReference type="EnsemblBacteria" id="ARF82375">
        <property type="protein sequence ID" value="ARF82375"/>
        <property type="gene ID" value="B6264_28995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36336">
        <property type="protein sequence ID" value="OEV36336"/>
        <property type="gene ID" value="HS99_0029665"/>
    </dbReference>
    <dbReference type="OMA" id="AMIPAFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="32323" checksum="AA93C6CBAA269567" modified="2017-01-18" version="1">MLSNRLAVVLVTALAPAVWGTTYLVTTEMLPPDRPLLAAVIRCLPAGLLLIALTRTLPRGGWWWRAPVLGALNIGGFQALLFIAAYRLPGGIAATVGAVQPLVTAGLSAALLGDRLTLRTVLSGIAGVAGVSLLVLRANAQLDAIGVVAALGGAVVMAFGVVLSKRWVSPAPLLATTGWQLTAGGLLLVPVTLLSEGAPPTHYTVDNVLGYAYLCLIGAALTYAIWFRGLRALPPTSLSFLSLLSPVVATLVGWLALGQDLSPLQALGAAVVLASLVVAQTQRPRPRTTDTGAAPSADRTAPVPGVGPSPLRENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N730</accession>
    <name>A0A1E7N730_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000382.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1475"/>
    <dbReference type="EnsemblBacteria" id="ARF79192">
        <property type="protein sequence ID" value="ARF79192"/>
        <property type="gene ID" value="B6264_09900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36507">
        <property type="protein sequence ID" value="OEV36507"/>
        <property type="gene ID" value="HS99_0028680"/>
    </dbReference>
    <dbReference type="OMA" id="AWHIINS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="49030" checksum="BC9FAF0E064EC485" modified="2017-01-18" version="1">MALGNLTDAFTSLLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYVYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVLRQLRFRDRQVVVLDAQGEDGVGEWNLIADALGIKPIRLDPMAARDGGVKLNPLDPAITQTGQLSLLRTIIEVAMGRGLEERAGFALKAAHAHVVASVKDRQPVLDDIIDTLRNPELSSVESLGVAVDEVQSWGLDVALVLDRLVDGDLRGMFDGPTTDGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAKEASAILKMASTRTIYMQKAEEARATGRVLGLPRWAVEIIPTLSPGIAVWDVNGNVQVVKHIITDTERPLVYTDRAMTEDAVAERTRAERNLAAEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N742</accession>
    <name>A0A1E7N742_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288987.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1463"/>
    <dbReference type="EnsemblBacteria" id="OEV36516">
        <property type="protein sequence ID" value="OEV36516"/>
        <property type="gene ID" value="HS99_0028740"/>
    </dbReference>
    <dbReference type="OMA" id="EWWDELD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028987099" evidence="2">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="9219" checksum="9E0EF1FD0246DC3A" modified="2017-01-18" version="1">MMGVCLGLFVLAWGVVRFFSVGAAIGMCVVAMVIPPAAAVFANKRDPEDDWWNDPRWDDPKWDDPGHDRDRPDHEPRDKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N778</accession>
    <name>A0A1E7N778_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="6" type="ORF">HS99_0028815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000302.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1447"/>
    <dbReference type="EnsemblBacteria" id="ARF79168">
        <property type="protein sequence ID" value="ARF79168"/>
        <property type="gene ID" value="B6264_09765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36529">
        <property type="protein sequence ID" value="OEV36529"/>
        <property type="gene ID" value="HS99_0028815"/>
    </dbReference>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="22124" checksum="D2529CDB0AAE827C" modified="2017-01-18" version="1">MIDPVTLDGPPAVGTFDQKRAENAIRELLLAVGEDPDREGLLETPARVARAYKEIFAGLWQVPEDVLTTTFDLGHDEMVLVKDIELTSVCEHHLVPFRGVAHVGYIPSTSGKITGLSKLARLVDVYARRPQVQERLTSQVADALMRILEPRGAIVVVECEHMCMSMRGIRKPGAKTITSCVRGQLRDPATRAEAMSLIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I8</accession>
    <name>A0A1E7N7I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291202.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79151">
        <property type="protein sequence ID" value="ARF79151"/>
        <property type="gene ID" value="B6264_09665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36604">
        <property type="protein sequence ID" value="OEV36604"/>
        <property type="gene ID" value="HS99_0028920"/>
    </dbReference>
    <dbReference type="OMA" id="FDMSATR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8624" checksum="764DF169344F9230" modified="2017-01-18" version="1">MGELSERDRAVLALEGRQWRTAGAKERAIREELGLSSTRYYQVLNGLLDREEALAFAPVLVNRLRRVREGRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T6</accession>
    <name>A0A1E7N7T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2458"/>
    <dbReference type="EnsemblBacteria" id="OEV36704">
        <property type="protein sequence ID" value="OEV36704"/>
        <property type="gene ID" value="HS99_0028535"/>
    </dbReference>
    <dbReference type="OMA" id="LAPICAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="16620" checksum="E172A1C34E200BB7" modified="2017-01-18" version="1">MKAERLKAAGPPVGAAALALALLTGWTAVGGAGAPRPVEADDGWMLLPTAGAASATSAFFTIRNPGDVPDELTGASWEFGGPVTLKRHLHQGAAGRWELAPALPVPSRGVLAMSPEDADLMIAAPPPLEPGRRVEFTLTFRHSPPLRLTATVLPPGERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N805</accession>
    <name>A0A1E7N805_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0027430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4774"/>
    <dbReference type="EnsemblBacteria" id="OEV36830">
        <property type="protein sequence ID" value="OEV36830"/>
        <property type="gene ID" value="HS99_0027430"/>
    </dbReference>
    <dbReference type="OMA" id="RSQVWVK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27158" checksum="5AFCB41EA893455C" modified="2017-01-18" version="1">MPILLVIALLLSLGIKTFFVQAFSIPSGSMENTLQIGDRVLVDKLTPWFGAEPERGEVVVFHDPGGWLEDTAPKDDGLMGSVQKVLSTVGLMPSADEKDLIKRVIAVGGDTVECNAGSPVKVNGVALDEPYLFPGATPCDNDPVGTVTVPKGKLWVMGDHRNNSRDSRPHQNLTGDGFVPVDDVVGRAFVVAWPISNWSTLPVPDTFDKVPSRAAAALPEQAPPAPAALALAGVVPIALWRRRRSRRSRRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N815</accession>
    <name>A0A1E7N815_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4783"/>
    <dbReference type="EnsemblBacteria" id="OEV36832">
        <property type="protein sequence ID" value="OEV36832"/>
        <property type="gene ID" value="HS99_0027470"/>
    </dbReference>
    <dbReference type="OMA" id="YTREHET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="900" mass="95254" checksum="53CE6ADB627196CE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8A5</accession>
    <name>A0A1E7N8A5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">HS99_0026915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281963.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6485"/>
    <dbReference type="EnsemblBacteria" id="ARF78653">
        <property type="protein sequence ID" value="ARF78653"/>
        <property type="gene ID" value="B6264_06770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36898">
        <property type="protein sequence ID" value="OEV36898"/>
        <property type="gene ID" value="HS99_0026915"/>
    </dbReference>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="43304" checksum="295EC1465D7C5DBC" modified="2017-01-18" version="1">MSGGTRVLVLNAGSSSVKYQLIDMLDGARLASGLVERIGESTGRLAHTPHSGDKRELLEVFPDHSAALKAVAEELAADGLGLDSPELAAIGHRVVHGGKRFTAPTVITDEVLKEIRRLIPVAPLHNPANITGIEVARALRPDLPQVAVFDTAFHASMPEYSARYAIDKAVADEHRVRRYGFHGTSHQYVSRATARLLGKDPAEVNVIVLHLGNGASASAVSGGHCVDTSMGLTPLEGLVMGTRSGDIDAGVVFHLHRVGGLSIDEIDDLLNRRSGLRGLCGENDMREIMRRADEGDADARLAFDSYVHRLRKYIGGYYAVLGRVDAIAFTAGVGENAAPVRAAATAGLEELGIAVDPELNSVRSGEARIISPAYSRVAVAVVPTDEELEIARQAFALVHRETGGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C8</accession>
    <name>A0A1E7N8C8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287052.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6843"/>
    <dbReference type="EnsemblBacteria" id="ARF78636">
        <property type="protein sequence ID" value="ARF78636"/>
        <property type="gene ID" value="B6264_06655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36918">
        <property type="protein sequence ID" value="OEV36918"/>
        <property type="gene ID" value="HS99_0027035"/>
    </dbReference>
    <dbReference type="OMA" id="MNTGRYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27602" checksum="75766AE3FB391659" modified="2017-01-18" version="1">MPAQQAPTGDSDAAADDRDKPQPSLWERLDRPSPAPRTTLTPHRIAEAAVAIADTEGLDAVTMRRLATALGVAPMAAYRYVSGKDELIELMVDFVYGQLPLDTPADGWREAMHSLAVHLRAMNLAHPWIARAATPFSLSPNQLAVPERAFAALAERGLDADTTMAVFRTVAVYVHGSSASEVALEDLRRARGWSDGDETRAGLAPRMTYLMGTGRYPSYQQYLQQATRKDDPDWHFTTGLDCVLDGIAAHFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L3</accession>
    <name>A0A1E7N8L3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81688">
        <property type="protein sequence ID" value="ARF81688"/>
        <property type="gene ID" value="B6264_24785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37040">
        <property type="protein sequence ID" value="OEV37040"/>
        <property type="gene ID" value="HS99_0004220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8083" checksum="22B526891BF9FE57" modified="2017-01-18" version="1">MQRGADEARKRHWAAGIPLAVLGICLLGSAVHLEKQGHDFESCAVHAMATIIQTVQEGKRSNQNRSATALSTWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q6</accession>
    <name>A0A1E7N8Q6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556107.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000394.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7429"/>
    <dbReference type="EnsemblBacteria" id="ARF81658">
        <property type="protein sequence ID" value="ARF81658"/>
        <property type="gene ID" value="B6264_24600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37071">
        <property type="protein sequence ID" value="OEV37071"/>
        <property type="gene ID" value="HS99_0004395"/>
    </dbReference>
    <dbReference type="OMA" id="GYGTMQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="32674" checksum="1A7189B52B593912" modified="2017-01-18" version="1">MTTALFDTAGTFKIAGKEVSRLGFGAMRLTGLGVWGEPADRDECVRVVRRAVELGVQLIDTADSYGPHVSEEIIREAIHPYPDDVLIATKAGLTRNGPDTIRTRDGLVRLGPKAWPPLGRPEYLRQQALLSLRRLGLDHIDLFQLHRVDPQVPLEDQVGELKGLQDEGKIVAIGLSQVTVDQIEQARAIAEIATVQNRYNLTDRSSADVLEHCTRHGIGFIPWAPVAAGELTRPGGPVDRIAAAHDARPSQVALAWLLARSEVVLPIPGTSKVTHLEENLAAATLRLTDVELGELTDADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q9</accession>
    <name>A0A1E7N8Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556071.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7409"/>
    <dbReference type="EnsemblBacteria" id="ARF81643">
        <property type="protein sequence ID" value="ARF81643"/>
        <property type="gene ID" value="B6264_24500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37085">
        <property type="protein sequence ID" value="OEV37085"/>
        <property type="gene ID" value="HS99_0004490"/>
    </dbReference>
    <dbReference type="OMA" id="DLYVMRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="19792" checksum="AAD962DEB759A073" modified="2017-01-18" version="1">MDGNKRWVSGDLQHPDRDPNRRQLVAQEQEPFGSILSCIDSRVPPELLFDTGLGDLYVMRTGGEAVGPVVTGSVEYGPMTSGTPLIVVLGHQRCGAVKAAYESFRDGKPLPGNLDAIAKALRPAYDQAVKEGGADPVETMSRAQVTLTAADLRSNQDLAPLVAKGSLAVVGAYYSLDTGAVEVLSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W0</accession>
    <name>A0A1E7N8W0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555701.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6646"/>
    <dbReference type="EnsemblBacteria" id="ARF81598">
        <property type="protein sequence ID" value="ARF81598"/>
        <property type="gene ID" value="B6264_24225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37135">
        <property type="protein sequence ID" value="OEV37135"/>
        <property type="gene ID" value="HS99_0004770"/>
    </dbReference>
    <dbReference type="OMA" id="WHRGTPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="24889" checksum="00271515D8E599E7" modified="2017-01-18" version="1">MVVDEVRRQLDQKLLSAVGAVLRTPDVRIYQACLWAKYGGPHTYDQRLHLDSRNQSLLVPSEDPAFHQVNAFVCLNDVDDDSATRVVSRQHTSGLAYDEADLDRARRPKLYALEQSTVGPAGSLLLFEARTYHRAVDISRPGAARFVLNTAFRTAQAEWVGYHAWPFRGKRPEWVAWLARSSPAQLQALGFPPPHRPYWTPGTLRAVGLRYPGIDLSAWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W7</accession>
    <name>A0A1E7N8W7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CbiA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81621">
        <property type="protein sequence ID" value="ARF81621"/>
        <property type="gene ID" value="B6264_24370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37108">
        <property type="protein sequence ID" value="OEV37108"/>
        <property type="gene ID" value="HS99_0004620"/>
    </dbReference>
    <dbReference type="OMA" id="QGSASWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="24372" checksum="47BD1953EB151278" modified="2017-01-18" version="1">MKPSVLVVSTDPQGSAVVWAERVGENLPFDFMAAHDQAEQLVHLKKTGAKIHVIANQKGGVGKTTTTVNLAACTFDVLGAKDEYEHIFIDTPGTLADEEILRRALEIADDVLVPMITEPLCFDPTARTIKKVIEPMDIPYRVVVNNWDPRDGRADLEDTEAYIAARGWPRAKTVLRRYKIHSRAVAEGTVVTQYKESGTAYRAREDFFRLSLELGYGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A6</accession>
    <name>A0A1E7N9A6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555151.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1289"/>
    <dbReference type="EnsemblBacteria" id="OEV37276">
        <property type="protein sequence ID" value="OEV37276"/>
        <property type="gene ID" value="HS99_0005630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="23605" checksum="E9D2C953BF658B45" modified="2017-01-18" version="1">MKIVIAGGHGKIALRLTRLLANRGESVVGIVRNPRHVDDVRAAGGEAVVLDLERATVDEVAATMVGADAVVFSAGSGNSATSARRDKVDRGAVVLVMDAAQQAGVRRFLHVSSINVGCADDRGIGEGYAIYLRAKRAAEQHIFARTELDWTVLRPGVLTDGNGEGTVELTLGNRVGPKHARFDQVARQDVAAVLVALIDRPETARRIYVVVGGGTPIEKAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E7</accession>
    <name>A0A1E7N9E7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37317">
        <property type="protein sequence ID" value="OEV37317"/>
        <property type="gene ID" value="HS99_0005885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13262" checksum="16982F8292AB45D6" modified="2017-01-18" version="1">MGAGAVVAHFGQESPIGRRQPDAVLCFESRDLTFGQRRAEIETVTLLAEGSSTSGKAGNSRQFGGDSAETFIHVALLFSQGHPPSGGAQTPTMPARTAAQPAPPITALLQRRPSADRHLRLGEMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA41</accession>
    <name>A0A1E7NA41_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5440"/>
    <dbReference type="EnsemblBacteria" id="OEV37353">
        <property type="protein sequence ID" value="OEV37353"/>
        <property type="gene ID" value="HS99_0006090"/>
    </dbReference>
    <dbReference type="OMA" id="PTAYNED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="760" mass="80863" checksum="733754CCEA98AC1C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA61</accession>
    <name>A0A1E7NA61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552345.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1120"/>
    <dbReference type="EnsemblBacteria" id="ARF79001">
        <property type="protein sequence ID" value="ARF79001"/>
        <property type="gene ID" value="B6264_08800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37569">
        <property type="protein sequence ID" value="OEV37569"/>
        <property type="gene ID" value="HS99_0026555"/>
    </dbReference>
    <dbReference type="OMA" id="EMDVRRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014395">
        <property type="entry name" value="Pen/GL7ACA/AHL_acylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043146">
        <property type="entry name" value="Penicillin_amidase_N_B-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001227">
        <property type="entry name" value="Pen_acylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001227-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="907" mass="99236" checksum="D4609B0526DF6955" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAQ7</accession>
    <name>A0A1E7NAQ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78094">
        <property type="protein sequence ID" value="ARF78094"/>
        <property type="gene ID" value="B6264_03430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37771">
        <property type="protein sequence ID" value="OEV37771"/>
        <property type="gene ID" value="HS99_0024570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="8190" checksum="C503A6EC51F67DFF" modified="2017-01-18" version="1">MPEERPASERFSLTLTPLGQQALTKIMATDNLPRPDAVNRALQAYAFLAEELKDGKALMLRDKDGNLERVHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY5</accession>
    <name>A0A1E7NAY5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0024815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3743"/>
    <dbReference type="EnsemblBacteria" id="OEV37866">
        <property type="protein sequence ID" value="OEV37866"/>
        <property type="gene ID" value="HS99_0024815"/>
    </dbReference>
    <dbReference type="OMA" id="AVHPCSG"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV37866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="34712" checksum="89E5BA2533B0BB7B" modified="2017-01-18" version="1">MTAEVLSLGARLQALHAPDRDGRRANVVLGGGSVEDLLGDAAYLGATVGRYANRIADGVLPLEGTTYRLATQPTGHTLHGGPDGFATRLWDGVPVREDRQVGVRLRLRSPAGDQGFPGTVTAEVTYLLDPDGGLSITYQAVTDAPTVVNLTNHAYFNLAGEGRGTVLDHLLHVDAAGYLPVDGNLIPLGPVEPVAGTPFDLRHARRIGTCITGEHPQILAAGRGFDHNWVLDGTGLRRAALLSHPASGRHVECLTTEPGLQVYTGNHFDGSLISPSGRRYTKHAGIALETQHFPDSPNRPDYPSTLLRPGEKYRSRTVYRFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB21</accession>
    <name>A0A1E7NB21_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">HS99_0025020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289203.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6014"/>
    <dbReference type="EnsemblBacteria" id="ARF78018">
        <property type="protein sequence ID" value="ARF78018"/>
        <property type="gene ID" value="B6264_02960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37844">
        <property type="protein sequence ID" value="OEV37844"/>
        <property type="gene ID" value="HS99_0025020"/>
    </dbReference>
    <dbReference type="OMA" id="KHKVPRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="58" mass="6694" checksum="4C5517F48ABC0F31" modified="2017-01-18" version="1">MAVPKRKMSRSNTRHRRAQWKATTPQLVPITVDGREHLVPRNLVRAYERGLLTPKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB63</accession>
    <name>A0A1E7NB63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366680.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2082"/>
    <dbReference type="EnsemblBacteria" id="ARF79485">
        <property type="protein sequence ID" value="ARF79485"/>
        <property type="gene ID" value="B6264_11660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37932">
        <property type="protein sequence ID" value="OEV37932"/>
        <property type="gene ID" value="HS99_0023990"/>
    </dbReference>
    <dbReference type="OMA" id="FPSAKFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="35202" checksum="0D7311EA6DF914A3" modified="2017-01-18" version="1">MTSSPPEEGSGAERADAEPVTAVADGADGAGDAERTARPLEVAVFTGPESAFFTTSTLILGERTAILVDAQLTRSAGRELAEWVAGKGRRLLAIVVTHQHPDHYFGAEEVLKLFPDAQLLAAPVVVEGIRRTVAAKVAQWKPVYGDDIPDNPSVPAPLLPQPLMLDRQVIPVLLLGQADCGESSVVHVPSIRTVIAGDFVSNGTHVWTADTTPAQRITWGHNLDRIADLGVDRVIAGHRAPEQGDDAARVLAFTGEYLRDFDRLLAEHPDDPEALITAMNERYGELTLPSFLQLGAAANTARAASPESGPEAEDGDSESEAADGDEDEGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK7</accession>
    <name>A0A1E7NBK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Appr-1-p processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288491.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000223.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3027"/>
    <dbReference type="EnsemblBacteria" id="ARF79717">
        <property type="protein sequence ID" value="ARF79717"/>
        <property type="gene ID" value="B6264_13115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38071">
        <property type="protein sequence ID" value="OEV38071"/>
        <property type="gene ID" value="HS99_0022985"/>
    </dbReference>
    <dbReference type="OMA" id="PVRYEAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17257" checksum="FACAC5F0ACF7683A" modified="2017-01-18" version="1">MAEITYVRGDATTPRGKGVKVIAHVCNDLGGWGKGFVLALSRRWPEPEAAFRRWHRERAKNDFGLGALQMVQVEPYVWVANLVGQRGIRTGRSTGVPVRYEAIDTGLAALAEHALELGASVHMPRIGCGLAGGRWSKVAPLIADRLTARGVPVTVYDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP8</accession>
    <name>A0A1E7NBP8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556783.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5928"/>
    <dbReference type="EnsemblBacteria" id="ARF79666">
        <property type="protein sequence ID" value="ARF79666"/>
        <property type="gene ID" value="B6264_12790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38126">
        <property type="protein sequence ID" value="OEV38126"/>
        <property type="gene ID" value="HS99_0023305"/>
    </dbReference>
    <dbReference type="OMA" id="DLDPWGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="38300" checksum="74B828DF350C40EE" modified="2017-01-18" version="1">MSTPIADHVTAEGPAAAGPLVVTADEGLAEHLLRLCAAAGTEPRLIRGAPPPRELWDAAPLVLVGDDQAERCAGLGRRAGVLLLGLDLDDPGVWVRAVQLGAEHVLFLPDAEAWLLDRIADAAEGVGSPAVTVAVLGGRGGAGASTLACALAVTAARTGRRTMLLDGDPLGGGLDVLLGGETARGLRWPDLAGARGRVSGAELARALPALKRLSALSCLSWDRGDTLTVPPEAMRSVLAAARRRGGLVVVDVPRHLDAAAGQALQQSDLALLVVPAELRAVAAADRVASAARMRLGDVRAVVRPVRASGLPAHRIARGLRLELAGELEPEPGLAEDVEKGVPPGMRDGGPLARFCATFLNEVLPPVSAVGGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS6</accession>
    <name>A0A1E7NBS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme A pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385980.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7149"/>
    <dbReference type="EnsemblBacteria" id="ARF79656">
        <property type="protein sequence ID" value="ARF79656"/>
        <property type="gene ID" value="B6264_12730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38135">
        <property type="protein sequence ID" value="OEV38135"/>
        <property type="gene ID" value="HS99_0023365"/>
    </dbReference>
    <dbReference type="OMA" id="WERPWDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25882" checksum="B6D787339F249A6C" modified="2017-01-18" version="1">MIKGAIERSGLPGWLEPVRDAAERVLPEQLSRFLPPREGGRAAAVLMLFGEGPDGPDLLLIERARSLRSHAGQPSFPGGALDPEDGDPDGPGPIAAALREAWEETGLDPAGVQVFAALPRLYIPVSSFVVTPVLGWWREESPVHPVDQGETGAVFRVTIADLADPANRVRLRHPSGHVGPAFAVAGRLVWGFTAGVIDRVLHHSGLELPWDPSRIVDLSDDALALVQGDLEHSRALPGGDAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX7</accession>
    <name>A0A1E7NBX7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0023275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5935"/>
    <dbReference type="EnsemblBacteria" id="OEV38187">
        <property type="protein sequence ID" value="OEV38187"/>
        <property type="gene ID" value="HS99_0023275"/>
    </dbReference>
    <dbReference type="OMA" id="GWWSATH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Tad" evidence="3">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="16402" checksum="905AF41404B2F31B" modified="2017-01-18" version="1">MERVRTARAAAAGRHGYGADAGSATVWLLALAMLGTVAFTATIAVGAVVAARHRAESAADLAALAAADRLLLDPDGGCARAAGIAATQGAALASCTVDRSADAVEVVAEVSVGGLPLRLPVGPVRARARAGPLRATVTAAEGGAGAGSGAGPGADGGAGAGPGGVPSSTSGAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC54</accession>
    <name>A0A1E7NC54_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0022290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366766.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1720"/>
    <dbReference type="EnsemblBacteria" id="ARF80210">
        <property type="protein sequence ID" value="ARF80210"/>
        <property type="gene ID" value="B6264_15980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38270">
        <property type="protein sequence ID" value="OEV38270"/>
        <property type="gene ID" value="HS99_0022290"/>
    </dbReference>
    <dbReference type="OMA" id="ADWAGKT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="774" mass="81931" checksum="4F637EF27BFB8468" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF5</accession>
    <name>A0A1E7NCF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829360.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000516.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3942"/>
    <dbReference type="EnsemblBacteria" id="OEV38372">
        <property type="protein sequence ID" value="OEV38372"/>
        <property type="gene ID" value="HS99_0020870"/>
    </dbReference>
    <dbReference type="OMA" id="VDGTVWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="23755" checksum="75000804429C2F83" modified="2017-01-18" version="1">MIIDVNTHANENATKVDFYFDPVCPFAWITSRWILEVEKQRELDLNFRVMSLSVLNEGRTDLPERYQRLMTTGWGPVRVCIAAAEQHGEHVLRDLYTELGTRLHDQDREADDTVIREALVAAGLPEELAEAAGSTAYDIALRKSHHDGMDPVGEEVGTPTIHVDGVAFFGPVLSAIPRGEDALRVFEGVRLLAGYPKFFELKRTRTGSLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN4</accession>
    <name>A0A1E7NCN4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000276.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82191">
        <property type="protein sequence ID" value="ARF82191"/>
        <property type="gene ID" value="B6264_27910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38418">
        <property type="protein sequence ID" value="OEV38418"/>
        <property type="gene ID" value="HS99_0021145"/>
    </dbReference>
    <dbReference type="OMA" id="AWGQPID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="8206" checksum="63B80A370749977D" modified="2017-01-18" version="1">MKTSRAARVAVTTATAVLLAVGAAVPAAHAAASGRRDVTADTCRAAGGHVEGSGYCVDASGKDAWGAEIDGQAVNPNPRPGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU4</accession>
    <name>A0A1E7NCU4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288328.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3118"/>
    <dbReference type="EnsemblBacteria" id="ARF82084">
        <property type="protein sequence ID" value="ARF82084"/>
        <property type="gene ID" value="B6264_27260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38520">
        <property type="protein sequence ID" value="OEV38520"/>
        <property type="gene ID" value="HS99_0021785"/>
    </dbReference>
    <dbReference type="OMA" id="NRPIMEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="831" mass="89398" checksum="2114558B09B7F530" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND47</accession>
    <name>A0A1E7ND47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cobH</name>
        <name evidence="5" type="ORF">HS99_0020290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551464.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene621"/>
    <dbReference type="EnsemblBacteria" id="ARF77633">
        <property type="protein sequence ID" value="ARF77633"/>
        <property type="gene ID" value="B6264_00705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38605">
        <property type="protein sequence ID" value="OEV38605"/>
        <property type="gene ID" value="HS99_0020290"/>
    </dbReference>
    <dbReference type="OMA" id="GAPIFCD"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="21593" checksum="560D356B6B1DE6F9" modified="2017-01-18" version="1">MIEYEKDGASIYRQSFATIRAEADLAALPADVSQVAVRMIHACGMTDLVEDLVYSPGVVASARAALHAGAPILCDVNMVASGVTRKRLPADNEVICTLTDPSVPELARAMGNTRSAAAMELWLPRLEGAVVAVGNAPTSLFRLLEMIEAGAPRPAAVIGVPVGFIGAAESKQALAEHPSSLEHLVVRGRRGGSAIAAAAINAIASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI3</accession>
    <name>A0A1E7NDI3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286344.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7334"/>
    <dbReference type="EnsemblBacteria" id="ARF81158">
        <property type="protein sequence ID" value="ARF81158"/>
        <property type="gene ID" value="B6264_21645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38749">
        <property type="protein sequence ID" value="OEV38749"/>
        <property type="gene ID" value="HS99_0018915"/>
    </dbReference>
    <dbReference type="OMA" id="MPQISVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004220">
        <property type="entry name" value="5-COMe_2-OHmuconate_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37950">
        <property type="entry name" value="PTHR37950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="12829" checksum="EC449687F040E6D6" modified="2017-01-18" version="1">MPQISVDYSSGLAGTFDRRALGLAINRLAEETIDAKPESCKTLFRQSEELVVGSTGLGGDAQVYVEFQIFPGRTPEAKAALSEGVMALLAEHVAPLPGGRLFTAVSIEDIDRESYRNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDY6</accession>
    <name>A0A1E7NDY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737788.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6551"/>
    <dbReference type="EnsemblBacteria" id="OEV38910">
        <property type="protein sequence ID" value="OEV38910"/>
        <property type="gene ID" value="HS99_0019855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="372" mass="39660" checksum="4FC18CDBCD9186AA" modified="2017-01-18" version="1" fragment="single">MAQLAVLLIIVVALAGVAAVVLARRRTTLDAAGVAKALGAAAEQLAAGKAPQARRRYARLARQLAGGPEELRTQRGLALLGQAEATIPTGDQQATLALHREAFPLLTDPARQLPRWSLLRLAEERTQAPDGDLGPVLALLQATATGAEPGEEAETAARARQWLQQLCRDARPEQRDHATARALAALPGQDWPVLARAALLSATDRAAETEPLLAAAAPHGSGELWFRWGAQLFTLHRDEPAVAAFDEALRRGPGEPSPWGRGPALRTDSLLFRGLARQRLGDTDAAWADLAAAAGESPSDPRPRYALGRLALLLGADDQAREQFTAALTVRPSFAPARFGLALVHERAQRHSEAAADYRAGLGQAPDWRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ9</accession>
    <name>A0A1E7NEQ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033350072.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000490.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3502"/>
    <dbReference type="EnsemblBacteria" id="OEV39191">
        <property type="protein sequence ID" value="OEV39191"/>
        <property type="gene ID" value="HS99_0000200"/>
    </dbReference>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="28377" checksum="778D864120292B18" modified="2017-01-18" version="1">MHPFLDHPGPLAFAHRGGELGHPENSLAAFEAAVALGYRYLETDVHATADGVLVAFHDSRLDRVTDRRGALAELPWQEVRRARIGGTEPVPLLEDLLGAFPGVRFNVDVKAAPAVGPLVEAIRRTDAWDRVCVGGFSDSRLAAVRAAAGPRLATSLGPREVARLRLRSLAGPLLPGRGAPFAGVCAQVPERHKGVRVVDRAFVRAAHRLGLQVHVWTVDDPTRIRALLDLGVDGIMADRIDVLRDVLGERGCWTDGSTGSSTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA8</accession>
    <name>A0A1E7NFA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550271.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000925.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3674"/>
    <dbReference type="EnsemblBacteria" id="OEV39328">
        <property type="protein sequence ID" value="OEV39328"/>
        <property type="gene ID" value="HS99_0001025"/>
    </dbReference>
    <dbReference type="OMA" id="WEPGLIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24796" checksum="950366D218F07F1E" modified="2017-01-18" version="1">MDQQHTGTPGAGPVSFLAAAAALGVMDAATRTARHAPPDTTGQNDPQQALSALLMLRHLREELAGWETGLIETARGAGATWGDLAEPLGVQSRQAAERRYLRLRPDRDAGTEAGSTGEQRVRAARDRRAGDRAVTTWARANAADLRRLAGQIGALDGLGPSAAPALQRLLDALGHHDPVRLLGPLAETRPLLAADHPAIVDRLDELAARAEQLRADSSHRRRTTRTDPTPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI9</accession>
    <name>A0A1E7NFI9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5098"/>
    <dbReference type="EnsemblBacteria" id="OEV39471">
        <property type="protein sequence ID" value="OEV39471"/>
        <property type="gene ID" value="HS99_0001890"/>
    </dbReference>
    <dbReference type="OMA" id="RYRRGAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008634">
        <property type="entry name" value="Gas-vesicle_GvpO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05800">
        <property type="entry name" value="GvpO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028743">
        <property type="entry name" value="GvpO_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="9027" checksum="6D15715BFDC39C74" modified="2017-01-18" version="1">MRIAAQQLQDLLGRVPESVSALKPVEGGWQADVEVVELERIPDTTSVLASYRVRLDEEGELQSYERIRRYTRGQVDRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK0</accession>
    <name>A0A1E7NFK0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3596"/>
    <dbReference type="EnsemblBacteria" id="OEV39263">
        <property type="protein sequence ID" value="OEV39263"/>
        <property type="gene ID" value="HS99_0000655"/>
    </dbReference>
    <dbReference type="OMA" id="GCLAGWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28770" checksum="0B3CDD25115F041A" modified="2017-01-18" version="1">MWPMHTITDWLRGLSGPVEYAAVGGMVFAEDALFFSFFIPGETAAVLGGFLAHQGEVSLGWMVLVVVCAAILGDSAGYEIGRHLGPPILRTRPLRRHAKQVDTVQDLIRRRGPAAVFIGRFIAFVRPLVPSLAGVSRMPYGRFLFYNALGGIAWGVGFTLLGYFAGAAYTRVEGTVGRVTTIVIAVIVAVALLAWFLRRHHSRGRGPSGDRSDGNSDETSDEPPGERSAPPSGAPSDETSQRPAHETSDAPSDETSDEPSDDRSGPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM8</accession>
    <name>A0A1E7NFM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556227.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000129.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5050"/>
    <dbReference type="EnsemblBacteria" id="OEV39511">
        <property type="protein sequence ID" value="OEV39511"/>
        <property type="gene ID" value="HS99_0002125"/>
    </dbReference>
    <dbReference type="OMA" id="VRDEFFM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="91"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18963" checksum="DF79C6C08A68E244" modified="2017-01-18" version="1">MRHQLLALLARQPAYGYELKQGLEQTFGAAYPQPNIGQIYVTLSRLEKSGLIHGTEVTQEGRPDKKVYEITEKGTEELAGWFEAPTEGPRVRDEFFMKLILAEGTDLADRLTLINNQRRHCINTMRGLNKLAATERGNRTSLLLIEGAVLHLQADLDWLERCQEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGS7</accession>
    <name>A0A1E7NGS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2788"/>
    <dbReference type="EnsemblBacteria" id="OEV39858">
        <property type="protein sequence ID" value="OEV39858"/>
        <property type="gene ID" value="HS99_0002970"/>
    </dbReference>
    <dbReference type="OMA" id="VMIQLVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="34391" checksum="72326115EFE38E68" modified="2017-01-18" version="1">MGSRREKRRRAAVAARRRARSARPPWEEPPTAVGRAAKGLTLGGTLAVILVPLWIIVLTSFSTPGAINRAGGLVIWPDGLTTDTYREMLSDPTVVTALTVSLGITAVGTAVSMAVSVLCAYGLSRPRSFGQRFVLLLLIVTMFVSGGLIPSFLVVTGLGGYDQWWALILPSALSVFNILVLRAFYQETSSELIDAARMDGAGDWRILWSVVLPTSRAVTAVTALFYAVGYWNSFFNVMLYMPTDSQKWPLQYVLLTYVNRANGLPGSVNSGFGNTQVQTAPLSLQMAVVVLTLVPLVIVYPFVQKHLRTGVLTGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUX9</accession>
    <name>A0A1E7MUX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000098">
        <property type="protein sequence ID" value="OEV32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290301.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000128.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7115"/>
    <dbReference type="EnsemblBacteria" id="OEV32252">
        <property type="protein sequence ID" value="OEV32252"/>
        <property type="gene ID" value="HS99_0040280"/>
    </dbReference>
    <dbReference type="OMA" id="KWEGPSL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15891" checksum="9DCED0B99B949B29" modified="2017-01-18" version="1">MAEGDPLSTHIFGVQLGGYNVESVKEISNLTVEQDVVEYKQVTQEGKLIVRKQPGARLPGEVTITRGLDKSGAFTDWIKETLNNGAINTARQNLTIEVKDTTGATLRRIQLTNAWASRWEGPTLSAGESSAATETVTIVFEEISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV22</accession>
    <name>A0A1E7MV22_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279669.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000133.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2983"/>
    <dbReference type="EnsemblBacteria" id="OEV32277">
        <property type="protein sequence ID" value="OEV32277"/>
        <property type="gene ID" value="HS99_0016305"/>
    </dbReference>
    <dbReference type="OMA" id="EYEPWHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="23831" checksum="BCD180C75E43A0AF" modified="2017-01-18" version="1">MSTSADRPSILLVHGAWHGAWCFDGLRPLLDAAGRRTHTVDLPTASSATAGLVDDVRAVREALGRIDGPTAVVAHSYGGVPVTEALAEAPNAVHAVFLAAYPLEAGESLASFLGLPESGEAVGSVPPPEDARELFFGDAAEGAAERALARLTPQSARSFRERVTTAGWRSTRSSYIVCDDDLALAPAHQERLAARTDTVHHLPGSHSPFLSRPTELAALLDRIATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVX6</accession>
    <name>A0A1E7MVX6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291088.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7517"/>
    <dbReference type="EnsemblBacteria" id="OEV32423">
        <property type="protein sequence ID" value="OEV32423"/>
        <property type="gene ID" value="HS99_0017195"/>
    </dbReference>
    <dbReference type="OMA" id="VGFEGMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15366" checksum="504C144FD074DC2C" modified="2017-01-18" version="1">MSIELAQCFIAVDDHDKALAFYRDVLGFEVRNDVGFEGMRWVTVGSPEQPGVEIVLEPPLADPHACEDDRRAAAELLAKGLLRGVIFRTDDCDATFERIRAAGAEVLQEPMDQPYGVRDCAFRDPAGNMLRFNQPRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVX8</accession>
    <name>A0A1E7MVX8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738010.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3791"/>
    <dbReference type="EnsemblBacteria" id="OEV32579">
        <property type="protein sequence ID" value="OEV32579"/>
        <property type="gene ID" value="HS99_0014950"/>
    </dbReference>
    <dbReference type="OMA" id="KVCVACR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="45101" checksum="6FCFE63E828389A2" modified="2017-01-18" version="1">MPQQTECPSCSEPMDPDDAFCGHCGTGRDGRTAPGAMPAGWAAARGGAVPPPRGPVCVNCGQPQVTEDGYCEGCGSAQPRPRDHMEKALAGVAGVSDRGVRHHRNEDFFTVAASSLPGGEPVVVAVVCDGVSSSDRPDEASETAVDAASESLLTSLEAGRDPEEAMRAAVADAARAVADLATDGAGPARPDVNAPACTFVSAVAAGGRITIGWVGDTRAYWIPDDRTTAVPFRLTQDDSWAARMVEAGLMGEAEAYADPRAHAITGWLGADAEEVVPHTLDFTPHVPGVLLICTDGLWNYAEAATDLAYFVRPDARTEPLAAAQTLVKFAVAAGGHDNITVAVLPIDPPAVSVEEAEETPTALDLKVITPSAAGGAPGDDPDYEPTLPDLPVIGSPAAPLPTVPTAPAAPPAAPAPPAAPPAPPAPAPASPPAVPPVPPHPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW54</accession>
    <name>A0A1E7MW54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288221.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3137"/>
    <dbReference type="EnsemblBacteria" id="ARF78310">
        <property type="protein sequence ID" value="ARF78310"/>
        <property type="gene ID" value="B6264_04710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32649">
        <property type="protein sequence ID" value="OEV32649"/>
        <property type="gene ID" value="HS99_0015370"/>
    </dbReference>
    <dbReference type="OMA" id="MHRRPPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="238" mass="24277" checksum="2917975556B1CE09" modified="2017-01-18" version="1">MSVLLEHPANVVAYRPTKPTAMVVIADPRVRNTVTRHLWALGVRDVIEVSSIAEARPRVSTPRDICVADVHLPDGSGLTILAETRAAGWPNGLALSAADDIGAVRSALAGGVKGYVVTGTRTNVAMPGRPGLPLGAAGLAGRMRRPGMPGMPGAAGAPGAPGAPGAPGPQQAAYRELSGREVEVLRLVAEGQSNKAIGVAMGLSALTVKSHLARIARKLGTGDRAGMVAVALRTGIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW58</accession>
    <name>A0A1E7MW58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385777.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3153"/>
    <dbReference type="EnsemblBacteria" id="ARF78297">
        <property type="protein sequence ID" value="ARF78297"/>
        <property type="gene ID" value="B6264_04635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32665">
        <property type="protein sequence ID" value="OEV32665"/>
        <property type="gene ID" value="HS99_0015450"/>
    </dbReference>
    <dbReference type="OMA" id="AYQMQVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="15727" checksum="130D74236AA7795B" modified="2017-01-18" version="1">MSSSPSPTATDEISWVLNPLLELPGVLHAVVATGDGLVEGASDGLGRASAERVAAMTATVHAAARAFTAAFTDTERPRLAQTVVESDLGYAIVVPAGENTSLAVFTAPDAQLGNVAYQMQLQVAALGRALASPSRQQVAGAPGAGATGAGSAGTTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW60</accession>
    <name>A0A1E7MW60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288251.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3154"/>
    <dbReference type="EnsemblBacteria" id="ARF78296">
        <property type="protein sequence ID" value="ARF78296"/>
        <property type="gene ID" value="B6264_04630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32666">
        <property type="protein sequence ID" value="OEV32666"/>
        <property type="gene ID" value="HS99_0015455"/>
    </dbReference>
    <dbReference type="OMA" id="RRRMVPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="13266" checksum="827F028054500A9B" modified="2017-01-18" version="1">MTAVPRRRMVPAYLATGGRSRPGTEGFERLTVLFADRADRAEPPTELEPEHRRLWELLRPGALTVVEAAAHLRLPVSATVFLAADLVEAGCLHARAPIPRAQQTDRSIVERLLVGLRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX56</accession>
    <name>A0A1E7MX56_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="14" type="ORF">HS99_0014275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279816.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5665"/>
    <dbReference type="EnsemblBacteria" id="ARF81451">
        <property type="protein sequence ID" value="ARF81451"/>
        <property type="gene ID" value="B6264_23305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33035">
        <property type="protein sequence ID" value="OEV33035"/>
        <property type="gene ID" value="HS99_0014275"/>
    </dbReference>
    <dbReference type="OMA" id="ECRGLIC"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="216"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="44958" checksum="4E980EA80F2ADF08" modified="2017-01-18" version="1">MTANQTHPDSTGDELVLDPVERAIADIALGRAVVVVDDEDRENEGDLVFAASAATPELMAFTIRYSSGVICAPMTGAELDRLKLPPMTQVNEDRKGTAYTVSVDAREGVDTGISAADRARTVRLLSSPGTEPGDLTRPGHVFPLRAVEGGVLVRPGHTEAAVDLARLAGLAPAGAIAEVVNDDGTMARLPELVAFAREHGLAIISIEDLIAYRRRTELHVDRAAVTALPTAHGEFTAVGYQGTIDGVEHIALVAGGLGADGRLPDGEDVLVRVHSECLTGDVFGSLRCDCGPQLEASLQRVAEAGRGVVLYLRGHEGRGIGLAHKLRAYELQEQGRDTVDANLELGLPADARDYSIAAQMLADLGVRSLTLLTNNPQKLTALTDHGLKVKGREAVEIAPGEHNVRYLRTKRDRMGHDLPGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXB3</accession>
    <name>A0A1E7MXB3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279762.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5640"/>
    <dbReference type="EnsemblBacteria" id="ARF81469">
        <property type="protein sequence ID" value="ARF81469"/>
        <property type="gene ID" value="B6264_23430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33054">
        <property type="protein sequence ID" value="OEV33054"/>
        <property type="gene ID" value="HS99_0014400"/>
    </dbReference>
    <dbReference type="OMA" id="HNDSSTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28381" checksum="B719BB48FEFDD3F9" modified="2017-01-18" version="1">MAQDKNKKRVSARERIQEAQRREQQAARRRQRIVVSVSAVVVLALAGGVALAINTGSKNDDKGAAAASAAPLVVPANATGPDGTVITYGKADAPHTMEVYEDFRCPVCKHFEAANGQTVKEITQDGQIKVEYHLAAFLDKNLGGKGSRTALAAAGAALNEGVDKFKAFHDVLYANQPDEREDGFGDVNHLLDLAGQVPGLKTDAFVKAVTDRTYAPWAAKVADAFNSSQVTGTPTVKVDGKPINLFTGNAPASPEQFTAQVKQVAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC9</accession>
    <name>A0A1E7MXC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0039615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554363.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000122.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene448"/>
    <dbReference type="EnsemblBacteria" id="ARF82694">
        <property type="protein sequence ID" value="ARF82694"/>
        <property type="gene ID" value="B6264_07975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32893">
        <property type="protein sequence ID" value="OEV32893"/>
        <property type="gene ID" value="HS99_0039615"/>
    </dbReference>
    <dbReference type="OMA" id="VHMRESA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="32944" checksum="6E4BADA3929722D8" modified="2017-01-18" version="1">MAVEQETLVEPDVAKREEARSLWGDAWRDLRRRPIFLLSVVLILLLVVMAVFPWAFTDANPRKADLVHDYLRRPDWTDFFGAGWFGYDAQGRSIYARVVYGARASITVGIFVTAAVTVLGGLTGMVAGYYGRAVDAVISRVVDIFFGIPLLLGALVLLNAFTTRTVWTVVLALAVLGWTQIARVMRGAVLTVKQSDYVVAGRALGAGTGRLMFRHILPNAVAPVIVVATIALGGYIATEATLSFLGIGLQDPTISWGIDISSAQKVIRTAPYVLFFPAAALSATVLAFIMMGDAVRDALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXD0</accession>
    <name>A0A1E7MXD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0014675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3427"/>
    <dbReference type="EnsemblBacteria" id="OEV33098">
        <property type="protein sequence ID" value="OEV33098"/>
        <property type="gene ID" value="HS99_0014675"/>
    </dbReference>
    <dbReference type="OMA" id="RFAINGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="24744" checksum="B764FD0F0C9E1A54" modified="2017-01-18" version="1">MCTDAIWRLPVTVCRITQFLGERTAGALLERAIASAGDALQPSMIQDQQVVPDIRRSRSRQDFAAPELLAAIDEVLEAVEHTLGVSCQYTEPSYSLNVHNDGDFYRSHQDTSAEYAPRRLLTFVYYLHRKPRPFGGGELRVFDAALPLHIETTGEWKERTWRDWEPEHDSIVFFRPAAWHEVRPVSCPSKQYADSRFAINGWLCSPDPANRGNDVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE2</accession>
    <name>A0A1E7MXE2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0014740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550949.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2707"/>
    <dbReference type="EnsemblBacteria" id="OEV33107">
        <property type="protein sequence ID" value="OEV33107"/>
        <property type="gene ID" value="HS99_0014740"/>
    </dbReference>
    <dbReference type="OMA" id="EIKQESM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="285"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="515" mass="54534" checksum="4A48E27948335293" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE5</accession>
    <name>A0A1E7MXE5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DPBB_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387311.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000812.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2690"/>
    <dbReference type="EnsemblBacteria" id="OEV33120">
        <property type="protein sequence ID" value="OEV33120"/>
        <property type="gene ID" value="HS99_0014820"/>
    </dbReference>
    <dbReference type="OMA" id="FSSRITW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198612" description="DPBB_1 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16534" checksum="087B7D0EBD67DFEA" modified="2017-01-18" version="1">MRAIGTNLRILAGAPLAAAALIALTAGSASAAIPVNKPMSGKATYYNDAGYGACGTQINASDQMLVAVSHTWWTSANPNNDPLCKGISVKVTYQGKTVTVPVKDQCPSCDSTHIDLSQPAFAKLAPLSKGVINGLTWQFVRSGANGKTLSLSEPVTGSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI9</accession>
    <name>A0A1E7MXI9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033347322.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5656"/>
    <dbReference type="EnsemblBacteria" id="ARF83017">
        <property type="protein sequence ID" value="ARF83017"/>
        <property type="gene ID" value="B6264_23350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33158">
        <property type="protein sequence ID" value="OEV33158"/>
        <property type="gene ID" value="HS99_0014320"/>
    </dbReference>
    <dbReference type="OMA" id="HEELFGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21868" checksum="C333A8C278CA5C45" modified="2017-01-18" version="1">MPDAVGALAAELRALPPSCGSVRLVAVDGHAGSGKTTFAGRLAAALGGAPVVHLDDLATHTELFEWTGRLREQVLEPLAAGRDAEHLVYDWTLRRFEGAARVPLAPVVLVEGVGAGRREVRPWLARVIWMELEAAVARRRGEERDGPELAGFWARWARAEAAHFAVDPSRPYAATRVDGVTGRILPGTVGEPSTSPLTCDITRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ2</accession>
    <name>A0A1E7MXZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylcrotonoyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388939.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3281"/>
    <dbReference type="EnsemblBacteria" id="OEV33307">
        <property type="protein sequence ID" value="OEV33307"/>
        <property type="gene ID" value="HS99_0038790"/>
    </dbReference>
    <dbReference type="OMA" id="AYLPIMS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="40"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="554" mass="58250" checksum="B6370F72FA05B89F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY24</accession>
    <name>A0A1E7MY24_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0038735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000066">
        <property type="protein sequence ID" value="OEV33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000113_gene3870"/>
    <dbReference type="EnsemblBacteria" id="OEV33311">
        <property type="protein sequence ID" value="OEV33311"/>
        <property type="gene ID" value="HS99_0038735"/>
    </dbReference>
    <dbReference type="OMA" id="QAFHVIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1664"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2041" mass="213066" checksum="356E3FF556790A86" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY26</accession>
    <name>A0A1E7MY26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558033.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3397"/>
    <dbReference type="EnsemblBacteria" id="ARF80448">
        <property type="protein sequence ID" value="ARF80448"/>
        <property type="gene ID" value="B6264_17410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33347">
        <property type="protein sequence ID" value="OEV33347"/>
        <property type="gene ID" value="HS99_0012180"/>
    </dbReference>
    <dbReference type="OMA" id="HPYVDVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30352" checksum="DEE8F8AA714DEA9E" modified="2017-01-18" version="1">MRSHQYGPDLTPPWKKQQPAPEVPAERDLVVEEAATGFCGAVVRCEKTAEGFTVTLEDRFGKHRVFPMVPRGFLLEGRVVTLVRPAGPAPSRAPGRTASGSVAVPGARARVARESRIYVEGRHDAELVERVWGDDLRIEGVVVEYLRGIDDLPAIVADFAPGPGRRLGVLVDHLLPGTKEQRIAAQVTGDSVLVVGHPYIDIWQAVKPSSVGISAWPAVPRGEDWKEGTCRRLGWPVDTPAAWKHILSKVNSYKDLEPELLGRVEELIDFTTLPGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY52</accession>
    <name>A0A1E7MY52_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="13" type="ORF">HS99_0012190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283903.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3395"/>
    <dbReference type="EnsemblBacteria" id="ARF80450">
        <property type="protein sequence ID" value="ARF80450"/>
        <property type="gene ID" value="B6264_17420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33349">
        <property type="protein sequence ID" value="OEV33349"/>
        <property type="gene ID" value="HS99_0012190"/>
    </dbReference>
    <dbReference type="OMA" id="REYMADS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="32942" checksum="34050CC5D729E9FC" modified="2017-01-18" version="1">MSSSGQHTRFAPDRGLTSRMVATMFVIGLLYVGFTGLLIALLRGAWPLIVLISGGLFVAQFWFSDKITERAMGARPVTAEQFPQLHGTVDRLCALADMPKPRVAVADNDMPNAFATGRNPQNAVVCVTTGLLRRLEPEELEGVLAHELSHVAHRDVAVMTIAGFLGVLAGAMTRIAMYGGFIGGNRNSNDQNAAIAALVIPLVSMVVYAISFLLTRLLSRYRELAADRAAAQLTGRPSALASALTKVTGQIAAIPTEDLRRSQPYNAFYFAPALSARETASQLLSTHPTLEKRLAQLAKISEQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY86</accession>
    <name>A0A1E7MY86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553463.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4008"/>
    <dbReference type="EnsemblBacteria" id="ARF80487">
        <property type="protein sequence ID" value="ARF80487"/>
        <property type="gene ID" value="B6264_17620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33384">
        <property type="protein sequence ID" value="OEV33384"/>
        <property type="gene ID" value="HS99_0012395"/>
    </dbReference>
    <dbReference type="OMA" id="AMEVYEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="18981" checksum="57EE50F84851DEA8" modified="2017-01-18" version="1">MTSTASHSATPPHGRPVPGDHGGVPGGALRPAPGPEGTLPTGAGPWSVRSVGPGRGRAALELYQHGELADVLVAARLAPQLVHGARRSPSAGRGSHVLAWGLLPADGATPSVVFTGGWRPFRTFRAAAAEVVTVAGVFWLAWAEGPYDTVLVEHPAGGGAERLALQRVRERRVRVRRAAAVGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC3</accession>
    <name>A0A1E7MYC3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385634.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80542">
        <property type="protein sequence ID" value="ARF80542"/>
        <property type="gene ID" value="B6264_17970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33438">
        <property type="protein sequence ID" value="OEV33438"/>
        <property type="gene ID" value="HS99_0012745"/>
    </dbReference>
    <dbReference type="OMA" id="REFTFRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="18423" checksum="518222DCBF5C09E1" modified="2017-01-18" version="1">MTSREESAARLQEQAARWSVGTGSANEVVLAACDALATGLDGPALRALAACEKAEADRELPNLLPAALEEQGLTYYTFGSDEASEAGVRLLASLMLDGRLTPRELAAQVQRRFGYDLELAVGLSSLDDEYDLLRVTGRTVDEIDAEVIAEARRVLRVEGNLDDRARERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE5</accession>
    <name>A0A1E7MYE5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288732.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6595"/>
    <dbReference type="EnsemblBacteria" id="OEV33458">
        <property type="protein sequence ID" value="OEV33458"/>
        <property type="gene ID" value="HS99_0012855"/>
    </dbReference>
    <dbReference type="OMA" id="MGRFPHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="26874" checksum="DC2CF59C40295449" modified="2017-01-18" version="1">MTTLDVVRGTAARVADAVKIYGVGGTEVRALDHVTVEFPAGRFTAIMGPSGSGKSTLMHCAAGLDTLTAGSAWIGDAELGSLNDRRLTLLRRERIGFVFQAFNLVPTLTVRENITLPLDLAGAAPDQAWLESLIEVVGLGDRLQHRPSELSGGQQQRVAVARALAGRPQVVFADEPTGNLDSRTGTEVLGLLRRAVDEMGQAVVMVTHDPTAAGFADEALFLADGRLVDRMERPTAASVLDRMKAFERRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYK2</accession>
    <name>A0A1E7MYK2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">HS99_0011980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030233759.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7019"/>
    <dbReference type="EnsemblBacteria" id="ARF80414">
        <property type="protein sequence ID" value="ARF80414"/>
        <property type="gene ID" value="B6264_17210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33313">
        <property type="protein sequence ID" value="OEV33313"/>
        <property type="gene ID" value="HS99_0011980"/>
    </dbReference>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11546" checksum="A697694A45A0E0A2" modified="2017-01-18" version="1">MYAIVRAGGRQHKVAVGDVLEIDRIEAKPGDSVELSTILVVDGDAVTSDPWVLAGVKAHAEVVDQTKGDKIVILRYKNKTGYRRRQGHRQKHTAVRITSIDSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV8</accession>
    <name>A0A1E7MYV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6304"/>
    <dbReference type="EnsemblBacteria" id="OEV33617">
        <property type="protein sequence ID" value="OEV33617"/>
        <property type="gene ID" value="HS99_0038635"/>
    </dbReference>
    <dbReference type="OMA" id="WRELTHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="589" mass="63687" checksum="643A64CC36B38293" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF9</accession>
    <name>A0A1E7MZF9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4489"/>
    <dbReference type="EnsemblBacteria" id="OEV33822">
        <property type="protein sequence ID" value="OEV33822"/>
        <property type="gene ID" value="HS99_0037695"/>
    </dbReference>
    <dbReference type="OMA" id="LYSAGHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="379" mass="39941" checksum="D2D085BEBB63E583" modified="2017-01-18" version="1">MRKRLRRARRRLRTAGVDYFRGGAADWPVLCALALLVPLMIVLNIWIPDWAPPTALVLPILAGALLLRPGSLVVLYALAALGLSAESVIHTGQRVASENPEAYVYGVTPGAALVVGAAGVGGLLLAQFRARVGVPWWGGSTMLFDLRERLRVQSRVPALPAGWHADMALRPAGGQSFSGDFVVAARTGPGQRLLEVVLADVSGKGMDAGSRALLLSGAFGGLVGSLPAHDFLPAANGYLLRQSWEEGFATAVHLVLDLDTGEYELLSAGHLPGMQRLAGAGRWEVKEAEGPLLGIYDGAKFDGVRGRLNRGDVLMLCTDGMVEAPGRDLAEGMDRLMGEADRLVPGGAPGSGAGAAAALIETVARDINDDRAVLLLWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH2</accession>
    <name>A0A1E7MZH2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="9" type="ORF">HS99_0037440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289886.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4311"/>
    <dbReference type="EnsemblBacteria" id="ARF80334">
        <property type="protein sequence ID" value="ARF80334"/>
        <property type="gene ID" value="B6264_16730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33827">
        <property type="protein sequence ID" value="OEV33827"/>
        <property type="gene ID" value="HS99_0037440"/>
    </dbReference>
    <dbReference type="OMA" id="QVRPEMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="546"/>
            <end position="553"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="596"/>
            <end position="600"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="650"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1044" mass="106238" checksum="8510020C1428D45B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP8</accession>
    <name>A0A1E7MZP8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000363.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1844"/>
    <dbReference type="EnsemblBacteria" id="ARF77753">
        <property type="protein sequence ID" value="ARF77753"/>
        <property type="gene ID" value="B6264_01370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33910">
        <property type="protein sequence ID" value="OEV33910"/>
        <property type="gene ID" value="HS99_0010530"/>
    </dbReference>
    <dbReference type="OMA" id="EGRIAWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="29174" checksum="8732489EC6F7C422" modified="2017-01-18" version="1">MLIAVDKVRAAADDRKREYRVEELAEAAGITTRTLRFYRERKLLQPPRKEGRIAWYGEEHLSRLRMIGELLERGHTLGGIAELIGAGESGRDVAGLIGLEAAIVAPWSDETPVRLDWEELKTAFGDQLTEENTAEAIAQGYISIEDDGITHVSRRLMDATTELVAEGVPLAAVLDASRRTREYVDAIAEIFIEVVSEHLLSALSGDTPLPPGEAARLTERILRVRPLARTVADAQFTLAMDRRVQAEYAELLRQRREYGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ3</accession>
    <name>A0A1E7MZQ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283088.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1846"/>
    <dbReference type="EnsemblBacteria" id="ARF77755">
        <property type="protein sequence ID" value="ARF77755"/>
        <property type="gene ID" value="B6264_01380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33912">
        <property type="protein sequence ID" value="OEV33912"/>
        <property type="gene ID" value="HS99_0010540"/>
    </dbReference>
    <dbReference type="OMA" id="CHEDVWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="21817" checksum="C251A205F6AFCA03" modified="2017-01-18" version="1">MRIGILGTGSMAAALGGAWVRAGHEVRVGGRDVAAARKLAVGIGAVGGGEPTEAVRFGEAVLVALPATAAVPVVGSLAGELAGRVLLDCTVPMAPGADGPALTTAGARDSVARRLASAAPAARVVKVFGICHESIWSLPRPSFEGAPLGVPYCADDQGAGDLTADLVGSMGCVPVHCGGLDRAGLLEAAAVFAIGVWWSGGEARHVFPSPALAPGAVDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV5</accession>
    <name>A0A1E7MZV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388028.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2186"/>
    <dbReference type="EnsemblBacteria" id="ARF77818">
        <property type="protein sequence ID" value="ARF77818"/>
        <property type="gene ID" value="B6264_01750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33962">
        <property type="protein sequence ID" value="OEV33962"/>
        <property type="gene ID" value="HS99_0010905"/>
    </dbReference>
    <dbReference type="OMA" id="ATTVYNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="580" mass="59279" checksum="992175A75A82B2F3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N5</accession>
    <name>A0A1E7N0N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385993.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6061"/>
    <dbReference type="EnsemblBacteria" id="ARF78152">
        <property type="protein sequence ID" value="ARF78152"/>
        <property type="gene ID" value="B6264_03790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34236">
        <property type="protein sequence ID" value="OEV34236"/>
        <property type="gene ID" value="HS99_0036890"/>
    </dbReference>
    <dbReference type="OMA" id="QHWTRRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="41871" checksum="C5D5A118210DE6C0" modified="2017-01-18" version="1">MTKARPGSTPRRGRLLALTALAAGLGATAWSLRDLPAAFGRRPDGEREERVRNSPQYRDGVFHNAPSELARAGSTPDFDRDTVRRMLFQREGRVPALPVPTMRPAPATGPAAEGVEITWYGHASALVEIEGSRVLLDPVWSDRCSPSAHVGPKRLHPVPVELEELPPVDAVLISHDHYDHLDMATVKRLVRSQSAPFAVPLGIGGHLRRWGVPEHRIIELDWDETCTLGELVLTLTSAHHFSGRGLTRNTTLWGSWVIAGPSRKVFYTGDSGYFEGYARIGEQHGPFDAALVQIGAYDAAWADIHMTPEDAVLAHRDLGAGLLVPVHWCTFNLGLHPWAEPIERLVKEAKTQAVPLAVPRPGERVDVDNPPELDGWWEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P9</accession>
    <name>A0A1E7N0P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285642.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6081"/>
    <dbReference type="EnsemblBacteria" id="ARF78170">
        <property type="protein sequence ID" value="ARF78170"/>
        <property type="gene ID" value="B6264_03890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34254">
        <property type="protein sequence ID" value="OEV34254"/>
        <property type="gene ID" value="HS99_0036990"/>
    </dbReference>
    <dbReference type="OMA" id="QEAFTWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28258" checksum="22F0332B3D40DA6F" modified="2017-01-18" version="1">MTAPATDPQAPSWERDGVRLEIDGELAVVTLCQPKRRNAQSPALWRALAQAGRELPGSVRVVLLRAEGVSFSAGLDRAMFTPEGIPGEPTFLQLAGSADKELDEAIASYQEAFTWWRRADLVSIAVVQGHAVGAGFQLALGCDLRVVADDVQFAMKETSLGLVPDLAGTKPLVELVGYARALEICATGRWVGAEEAVATGLANLAVSGAELDSAARDLAAALLAAPRGAVIETKALLQGACGRSYDEQRSAERVAQARRLRELAGIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y9</accession>
    <name>A0A1E7N0Y9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551338.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000747.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6411"/>
    <dbReference type="EnsemblBacteria" id="ARF78722">
        <property type="protein sequence ID" value="ARF78722"/>
        <property type="gene ID" value="B6264_07140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34331">
        <property type="protein sequence ID" value="OEV34331"/>
        <property type="gene ID" value="HS99_0036395"/>
    </dbReference>
    <dbReference type="OMA" id="KRIWTRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18908" checksum="4A70C751DD4D5591" modified="2017-01-18" version="1">MSTGSPAGGFRRVTLADPLVEPLLRELTHEYVSRYGPGAHQEMARYPAEAFAEPHGVLLLLLEDGEPVAGGAYMRHDAHTAEVKRMWTHSAHRRRGLARRVLAELERTAAAAGYHRIFLTTGPRQPEAKGLYLSAGYTPLFDVTADPLTIGPLPFEKPLPALVPLHRPVPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N157</accession>
    <name>A0A1E7N157_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7205"/>
    <dbReference type="EnsemblBacteria" id="ARF79220">
        <property type="protein sequence ID" value="ARF79220"/>
        <property type="gene ID" value="B6264_10110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34401">
        <property type="protein sequence ID" value="OEV34401"/>
        <property type="gene ID" value="HS99_0035930"/>
    </dbReference>
    <dbReference type="OMA" id="CASVTAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="21706" checksum="01E5DD634AA76C90" modified="2017-01-18" version="1">MVPVRLTGPRLAVREYHHTPAEVDALHALYGDPEVTRYLPFEPRDRETCADQIELYLEEAMAEERDTYRLAVVRREDAEDPEDALPIAHASLTLGKYRSAYLGYVLSRPVWGRGYAGEIAGLLCELSFGPLGLHRLVARVDVDNAASAKVLTKLGFQLEGRARHDLYKGGVWSDSYQYSLLADEWTGPPVPPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N180</accession>
    <name>A0A1E7N180_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289801.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79250">
        <property type="protein sequence ID" value="ARF79250"/>
        <property type="gene ID" value="B6264_10275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34432">
        <property type="protein sequence ID" value="OEV34432"/>
        <property type="gene ID" value="HS99_0036095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="238" mass="25036" checksum="B3AA22AC716C7636" modified="2017-01-18" version="1">MPRRTGYAIGAPCWADCITPDLNGSREFYSALLGWEFVTESPGYQLAVLGGEVIGGFGAAPVGLPPLATWNVYLATKDAEYSCAQVGRLGGRVVMPPVPAGENGRLLLAVDPSGVTVGFWEGARAEGVVLADEPGAICGHELRVPSATRAEAFYGPMFGYRIGADGEFALDGVAHARVVESDQGRPCWLPLFGTADPADGVRRAVERGARLVRPGRGEPPVLRDPWGAEFGLVTATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N193</accession>
    <name>A0A1E7N193_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0035810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286579.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene365"/>
    <dbReference type="EnsemblBacteria" id="ARF78932">
        <property type="protein sequence ID" value="ARF78932"/>
        <property type="gene ID" value="B6264_08385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34469">
        <property type="protein sequence ID" value="OEV34469"/>
        <property type="gene ID" value="HS99_0035810"/>
    </dbReference>
    <dbReference type="OMA" id="WMADYGF"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="466" mass="49535" checksum="C60F8B275C7505A0" modified="2017-01-18" version="1">MRYHNSIIDLVGNTPLVKLNKVTEGISATVLAKVEYFNPGGSVKDRIAMRMIEAAEASGALKPGGTIVEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSTDKINTLRAYGAEVVVCPTAVAPEHPDSYYNVSDRLVRETPNAWKPDQYSNPDNPASHYHSTGPELWEQTDGRITHFVAGVGTGGTISGTGNYLKEVSGGKVKVVGADPEGSVYSGGTGRPYLVEGVGEDFWPTAYDRNVADEIVAVSDKDSFQMTRRLAKEEGLLVGGSCGMAVVAALEVARKLGPDDVVVVLLPDGGRGYLSKIFNDDWMADYGFLPSSTDEAHIGEVLARKESVAQGGVPQFVHMHPNETVAEAVRVLREYGVSQMPVVSPGAGHPDIMAGEVIGSVVEKLLLEGIFAKEIELTDTLDKVMSKPLPVVGSGETVTNLMTVLEKADAAVVLVEGKPQGIVTRQDLLSFLTTRGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J5</accession>
    <name>A0A1E7N1J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5586"/>
    <dbReference type="EnsemblBacteria" id="OEV34545">
        <property type="protein sequence ID" value="OEV34545"/>
        <property type="gene ID" value="HS99_0035215"/>
    </dbReference>
    <dbReference type="OMA" id="GYPVNWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17563" checksum="0B7B4E0F86593C70" modified="2017-01-18" version="1">MGVRRRRAADLADCVRALADVHAADGYPAEWPERPAAWLTPDGLLAAWIAEADGRTAGHVGLARSAPGDMAPGLWSRRAGGRPELTAVIGRLFVAPAARGRAAGALLLASAVAHARVLGLHPVLDVLSTDTAALALYRRLGWTPLGSGEQRWASGRTVVVHCFAAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M9</accession>
    <name>A0A1E7N1M9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34581">
        <property type="protein sequence ID" value="OEV34581"/>
        <property type="gene ID" value="HS99_0008750"/>
    </dbReference>
    <dbReference type="OMA" id="NDGQRDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="20849" checksum="79B76945FB655190" modified="2017-01-18" version="1">MVAGLAVALAGLPTSQDTTPAGSTRPKAHAIAGVRPQQLAAEAGAALDRGGELAEEGTSGTDTVTKTAKKATAKKAAPAKTVTGKKAAPAKKTAAKKTAGGARPRTGAKKTAAATGTRPVQTGAEPAPDKSETAAPAPRRRTTGATSDSVLSVLADTPGPLRAREVTARLGVDESADTVNAVRTMLERLTKAGRAQRPGRGLYARLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A4</accession>
    <name>A0A1E7N2A4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83071">
        <property type="protein sequence ID" value="ARF83071"/>
        <property type="gene ID" value="B6264_25655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34812">
        <property type="protein sequence ID" value="OEV34812"/>
        <property type="gene ID" value="HS99_0010090"/>
    </dbReference>
    <dbReference type="OMA" id="MLEDWSQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16044" checksum="CEA03D5A7AEA6979" modified="2017-01-18" version="1">MPDDVGHEIADALGALLRRGARARLYARLTGNLGEAVDETTYPVLSGLARTGPCSAADLAGEIGLDRSGVTRRATRLEEAGLLCREPDPDDRRAILLALTETGQQAVQITRQRLVTIIEASLASWPPEEAQSFAHQLHRFVTTGPFAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M7</accession>
    <name>A0A1E7N2M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically inducible protein OsmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4649"/>
    <dbReference type="EnsemblBacteria" id="ARF81926">
        <property type="protein sequence ID" value="ARF81926"/>
        <property type="gene ID" value="B6264_26285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34713">
        <property type="protein sequence ID" value="OEV34713"/>
        <property type="gene ID" value="HS99_0009495"/>
    </dbReference>
    <dbReference type="OMA" id="GWSACFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14667" checksum="3F28C4FB6207A4AE" modified="2017-01-18" version="1">MAVNYTATVEVTGEGRNGGTARSTDGLLEHRLSIPKELGGAGDATNPEQLFAAGWAACFLGALRHAAAQRKIRLTSTSITAEVTLLHGDDGEFSLLATLAPRLGGVDQRTAEDLAEAAHRICPYSKATRGNIPVTINAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T9</accession>
    <name>A0A1E7N2T9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein HS99_0034715</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287963.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7663"/>
    <dbReference type="EnsemblBacteria" id="OEV34996">
        <property type="protein sequence ID" value="OEV34996"/>
        <property type="gene ID" value="HS99_0034715"/>
    </dbReference>
    <dbReference type="OMA" id="NWRCAEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14966" checksum="59B7C3DBDAB9ED2E" modified="2017-01-18" version="1">MGLGRYGERVAARHLAESGLRILDRNWRCAEGELDIVALDGDTVAVCEVKTRSERGFQQPSEAIDRAKAARLQRLAERWLAERWPGHFARLAGPGYDPGPSDPQWPPAPPGGVRIDLVAVVNRARGAAVVDHLRGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B8</accession>
    <name>A0A1E7N3B8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000463.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4469"/>
    <dbReference type="EnsemblBacteria" id="ARF78432">
        <property type="protein sequence ID" value="ARF78432"/>
        <property type="gene ID" value="B6264_05415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35165">
        <property type="protein sequence ID" value="OEV35165"/>
        <property type="gene ID" value="HS99_0033840"/>
    </dbReference>
    <dbReference type="OMA" id="LMNQLRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="395" mass="41936" checksum="173E02F7C67912CE" modified="2017-01-18" version="1">MSFAPSDGYDAFEILDPAAAPAPPYGSGSLCDLLPSVAAGLGVPGFTATLPIAPADRVVVFLVDGLGWELLLRHPEYAPFLSSLAGSSMGGTGRPLTAGFPSTTATSLASVGTGTPPGLHGLAGYTVAVPGADYLMNQLRWQPHTDPQAWQPYPTVFEQTQRAGVATAQVSSPLFAQTPLTRVALSGGSFLGRTTGEERMDLAASWLAEHDRALVYTYVSELDGAGHRFGVDSDEWRMTLDAVDRLARRLAEQLPPRSAMYVTADHGMIDIAPEDRIDFDEDWELGAGVALLGGEGRARHVYAVPGAAADVHTVWSEVLGDRMWVATRDEAIAAGWFGPTVDERVYHRIGDVVAAARDDIAITASRNEPGESAMIGLHGSMTPVEQFVPLLEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U0</accession>
    <name>A0A1E7N3U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35361">
        <property type="protein sequence ID" value="OEV35361"/>
        <property type="gene ID" value="HS99_0032625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="12315" checksum="6834CE3DA2B25EC9" modified="2017-01-18" version="1">MPPTIPFQVVLYLAKSNSAFPERELRMCESYANTFNWDISLIVVDDETHAKGPEHRPMLQAALQRLLDRRAGAILVPTKATISPIDGEFNEFAERVEKASGFIQIATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N433</accession>
    <name>A0A1E7N433_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxycytidine triphosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283427.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3874"/>
    <dbReference type="EnsemblBacteria" id="OEV35446">
        <property type="protein sequence ID" value="OEV35446"/>
        <property type="gene ID" value="HS99_0032315"/>
    </dbReference>
    <dbReference type="OMA" id="WTLEIRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19432" checksum="04AAD365D06D2F4D" modified="2017-01-18" version="1">MILSGPEIHAEVMAGRIHIDDYDPERIEPNSYGFRLAEDILWYEQDVIDCFEPPKAEHVKMGPEGMVLEPGRFYLGGTMEAMGSPNYAATLYACRSASTLGIWIQFSAPLGHSGAVFPWTLEMKVAHPVRVYPGMMIGKLAFWAMQGEAVGYHGKYTGSRSAVASRLSLDQHHGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D9</accession>
    <name>A0A1E7N4D9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">HS99_0033240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282878.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000467.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5341"/>
    <dbReference type="EnsemblBacteria" id="ARF80747">
        <property type="protein sequence ID" value="ARF80747"/>
        <property type="gene ID" value="B6264_19180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35323">
        <property type="protein sequence ID" value="OEV35323"/>
        <property type="gene ID" value="HS99_0033240"/>
    </dbReference>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="35545" checksum="C44F59D344FC25CC" modified="2017-01-18" version="1">MTTNEPGPKHVPVMLQRCMDALAPAISRPGAVVVDATLGLGGHSEALLTQFPEVRLIAVDRDPQALKLSGERLAPFGDRATLVHAVYDEIPEVLERLGIDRVDGVLFDLGVSSMQLDEADRGFAYAQDAPLDMRMDQTRGISAAEVLNTYSHGDLARILKVYGEERFAGKIASVILRERAKEPFTNSARLVELVRNAIPAATRRTGGNPAKRTFQALRIEVNGELEVLDRAIPAALDVLALGGRMVVMSYQSLEDRLVKQYFAAGATSTAPPGLPFVPEEHQPWLKLITRGAELATEEEIEENRRAAPVRLRVAERIRDRSKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4G6</accession>
    <name>A0A1E7N4G6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0006570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5372"/>
    <dbReference type="EnsemblBacteria" id="OEV35579">
        <property type="protein sequence ID" value="OEV35579"/>
        <property type="gene ID" value="HS99_0006570"/>
    </dbReference>
    <dbReference type="OMA" id="VHGMGLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="49"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="335"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="692" mass="73788" checksum="327E424EAB3B69DB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4I8</accession>
    <name>A0A1E7N4I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366829.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80793">
        <property type="protein sequence ID" value="ARF80793"/>
        <property type="gene ID" value="B6264_19455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35600">
        <property type="protein sequence ID" value="OEV35600"/>
        <property type="gene ID" value="HS99_0006685"/>
    </dbReference>
    <dbReference type="OMA" id="ANYQQGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="19975" checksum="2F58ED7C74A95029" modified="2017-01-18" version="1">MTSEQQPPEAAASRPSRGLAIAVAAVLAVLLAVVATALLWPEDAPGPAAAPPPPSPTATPTPTPTPTPTPTRPQPPYAFFPVGTCFDHPQLSPVITKAEERPCTTPHDGEVIADLKLPDGLSGEIPIALAMRDGCKDAEATAKAHQGDGKSYYPRQFGPATANYQQGWRDYTCTLTAGSKQGAPKLTGPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J9</accession>
    <name>A0A1E7N4J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280426.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5385"/>
    <dbReference type="EnsemblBacteria" id="ARF80784">
        <property type="protein sequence ID" value="ARF80784"/>
        <property type="gene ID" value="B6264_19400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35592">
        <property type="protein sequence ID" value="OEV35592"/>
        <property type="gene ID" value="HS99_0006635"/>
    </dbReference>
    <dbReference type="OMA" id="WMAVLWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="525" mass="57736" checksum="B43DD3426C90D625" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q0</accession>
    <name>A0A1E7N4Q0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551169.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene920"/>
    <dbReference type="EnsemblBacteria" id="ARF80853">
        <property type="protein sequence ID" value="ARF80853"/>
        <property type="gene ID" value="B6264_19805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35660">
        <property type="protein sequence ID" value="OEV35660"/>
        <property type="gene ID" value="HS99_0007035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="10233" checksum="7BBEACCC357AC022" modified="2017-01-18" version="1">MRADHEIRVEVPGVRPPSVRTLSPDGLESLWNSICFRPMSPLQREILERALAGPCAERNVIRHLAANPYLALPFGDCELRISWANTAEGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z7</accession>
    <name>A0A1E7N4Z7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0007770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281481.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene775"/>
    <dbReference type="EnsemblBacteria" id="ARF80978">
        <property type="protein sequence ID" value="ARF80978"/>
        <property type="gene ID" value="B6264_20545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35767">
        <property type="protein sequence ID" value="OEV35767"/>
        <property type="gene ID" value="HS99_0007770"/>
    </dbReference>
    <dbReference type="OMA" id="PFRYMDT"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="726" mass="77662" checksum="6B8135E774ECD329" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N596</accession>
    <name>A0A1E7N596_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3375"/>
    <dbReference type="EnsemblBacteria" id="OEV35824">
        <property type="protein sequence ID" value="OEV35824"/>
        <property type="gene ID" value="HS99_0008125"/>
    </dbReference>
    <dbReference type="OMA" id="HEPRAQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="28567" checksum="2520BA8398C1C1E4" modified="2017-01-18" version="1">MTPAPEEPSVVQSDRLAFSDLDETLIDCKSMFDFLDFYLGDRYGASGVRRAARVRAELVALVAAGTPREQANRAYYRVWAGEREESVRAAGWEWFAQRSRSAGFYIAATREALTRHRAAGDPVVLVSGSFPALVEPVARDIGAAHVVCSRPEVRRGVFTGELVGEPVIGEEKRRAVRALLRAYPHVDPADCYGYGDHVSDLPMLTEVGHPVVVGDPDLVDRVPGARLLPVGRPLPPDALTADGLTAGQPVARELTAGALAAGAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5K5</accession>
    <name>A0A1E7N5K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene821"/>
    <dbReference type="EnsemblBacteria" id="OEV35965">
        <property type="protein sequence ID" value="OEV35965"/>
        <property type="gene ID" value="HS99_0007535"/>
    </dbReference>
    <dbReference type="OMA" id="RFRPRME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="29114" checksum="E42F31DD897D18C6" modified="2017-01-18" version="1">MSGERRQSVPTTSRSYASYVAVGDSFTEGMCDDLHPDGHYRGWADRVASALAAEAGAGGDFRYANLAVRGKLIGQIHDEQLATAVGMGAELVTLAGGLNDVLRPGCDIARVERLLGRCAAELRATGATVVLFTSTDPTRRLAGSARLLPAILRMKAFVQELGQQDGFAVVDLFSAPCFDDRRLWAEDRLHLSPEGHRRVAEGVLEALGRPTASDWRAPLPAAAPPGRAEKLRSDARWLGAHLGPWIGRRLTGRSSGDGRPPKRPELLPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L0</accession>
    <name>A0A1E7N6L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553084.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000773.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4890"/>
    <dbReference type="EnsemblBacteria" id="ARF82379">
        <property type="protein sequence ID" value="ARF82379"/>
        <property type="gene ID" value="B6264_29020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36331">
        <property type="protein sequence ID" value="OEV36331"/>
        <property type="gene ID" value="HS99_0029640"/>
    </dbReference>
    <dbReference type="OMA" id="DACETKT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26373" checksum="D0063EA242E9D3A9" modified="2017-01-18" version="1">MPFRSAPEGGRLRATAAALLALLALTALVGVAPAPEPLLGSEIRRIPTEEHVLALTFNAAWNETGLDTVLGVLRDRAAPAVFFPTGDFADHHPRALRAIAAAGHGLGNHSYSHPDFTALSPDRARSEVRRADTAIRAASDAEPLPFFRFPYSATSPQAVATVNGLGYADLEYTADTKGYLGPVHGMTADRAVERALAALTPGAVLQLHVGASEESGPDTCLDAEALPRIIDGARARGYRIIDLRTLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N0</accession>
    <name>A0A1E7N6N0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284472.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4894"/>
    <dbReference type="EnsemblBacteria" id="OEV36335">
        <property type="protein sequence ID" value="OEV36335"/>
        <property type="gene ID" value="HS99_0029660"/>
    </dbReference>
    <dbReference type="OMA" id="QWRNERP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="18217" checksum="4040324C05AE2A05" modified="2017-01-18" version="1">MADHLDRVVAQWGAERPDLDVSPMEVFGRLKRLFRLVDAELNRTFAEHGLDAPSFDVLATLKRSGPPYRLTPTGLMESAMVTSGAITQRLDRLEARGLVTRTRSDQDRRSRDVELTPEGHALIDRALPAHVANEHRLLAGLDEAQKAALIEAMRALLEDLGEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R0</accession>
    <name>A0A1E7N6R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385519.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7752"/>
    <dbReference type="EnsemblBacteria" id="OEV36397">
        <property type="protein sequence ID" value="OEV36397"/>
        <property type="gene ID" value="HS99_0030030"/>
    </dbReference>
    <dbReference type="OMA" id="RDWYWTS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="425" mass="43305" checksum="320F34223D08C0E1" modified="2017-01-18" version="1">MSQHPLGLRDFRLLFLGRTVSTLGDAVVPAALAIAITRATGSSAALALVLGCAMVPRLLLLPFGGVAGDRLDPRLVALTTDLLRAVTQLLVGLELLGDRPDLTHIAIASAAGGLASAFAMPTTSPLVRAAVPAEHRLRANALLGSATSAARLGGPALAGLLVYTAGPGWAFVADGVSFLLSAALLSRVRLVPARDPLAAAGGPPAGARPLRRDLAEGWREVRARDWYWTSLLAHGVWNGASAVALTLGPLIAATRLGGDGVWVAITQAGAIGLLLGSLAAGRLRPRRPVLVGNLALALYGLPLLALAVPAPAPVTVAAYGVALAGLGFLNPVWETVVQEEFPPRVLARVTSYDWLLSLAAAPFGYVLAPLAADAWGSRVPLLAAAALVTLVCAGTAAVPGVRRLGTAPGAAEPAAVERPPVQIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V1</accession>
    <name>A0A1E7N6V1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280641.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7792"/>
    <dbReference type="EnsemblBacteria" id="ARF82277">
        <property type="protein sequence ID" value="ARF82277"/>
        <property type="gene ID" value="B6264_28430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36420">
        <property type="protein sequence ID" value="OEV36420"/>
        <property type="gene ID" value="HS99_0029185"/>
    </dbReference>
    <dbReference type="OMA" id="LIEEWLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="15025" checksum="3FC1B47EB73B98EC" modified="2017-01-18" version="1">MTEKAAIHCDEFLPYPPARVWEALTDPELHARWWAAGDVKAVVGHRFTLDMGPWGQQPCEVVEVEVERLLRYSFAAGSLDTTVTWRLVPEGHGTRLLLEHTGFDLDNPMGRQAHQGMGQGWPSVLRRIAPALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V9</accession>
    <name>A0A1E7N6V9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386054.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8084"/>
    <dbReference type="EnsemblBacteria" id="ARF79806">
        <property type="protein sequence ID" value="ARF79806"/>
        <property type="gene ID" value="B6264_13635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36193">
        <property type="protein sequence ID" value="OEV36193"/>
        <property type="gene ID" value="HS99_0030580"/>
    </dbReference>
    <dbReference type="OMA" id="PTHVHRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26631" checksum="A72B2819DD07CCCF" modified="2017-01-18" version="1">MLPRPTPATSEALPGGRGFAVVDVEATGRSPWRHRVVEVAVVLLNERLRPEGEFATLLDPLGPVGPTHVHRIRQADVEGAPRFREIAPRLLELLAGRVLVGHHVSCDHAFLDREFARIGVPLPPVPVLCTMRLARAHLPEVRGYGLAACAEAAGLGWYPAHTALGDARVTAELLRHCVGEPSCPPDDWAGPLREAARVPWPRLGRARSRPSGGPVPLLRREAPYGPWLPGSAAPELVLTQAGAMCSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N710</accession>
    <name>A0A1E7N710_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene192"/>
    <dbReference type="EnsemblBacteria" id="OEV36487">
        <property type="protein sequence ID" value="OEV36487"/>
        <property type="gene ID" value="HS99_0029465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13056" checksum="BDB2A13407724F13" modified="2017-01-18" version="1">MVTAPDGAAVRPLLVLDGLGSLAVFELAPGQVTRAVSHATVQELWQVTAGSGELWRRQDGREETLRLTPGTAASIPLGTAFQFRADPDTDGPLRITAVTMPPWPGTDTEARPEQGPWRATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N797</accession>
    <name>A0A1E7N797_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386326.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7887"/>
    <dbReference type="EnsemblBacteria" id="ARF79141">
        <property type="protein sequence ID" value="ARF79141"/>
        <property type="gene ID" value="B6264_09615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36555">
        <property type="protein sequence ID" value="OEV36555"/>
        <property type="gene ID" value="HS99_0028970"/>
    </dbReference>
    <dbReference type="OMA" id="HGYALIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12562" checksum="3D36C477348B75ED" modified="2017-01-18" version="1">MTERSMQEPTLLLLTALADAPRHGYALIQEIAAISDGRVKMRTGTLYGALDRLLGQGLIEVAAEEVVDGRARRTYALTDAGRGALATEAERLRAVATEAERRLSVAVVSPRVRGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R1</accession>
    <name>A0A1E7N7R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1479"/>
    <dbReference type="EnsemblBacteria" id="ARF79195">
        <property type="protein sequence ID" value="ARF79195"/>
        <property type="gene ID" value="B6264_09920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36503">
        <property type="protein sequence ID" value="OEV36503"/>
        <property type="gene ID" value="HS99_0028660"/>
    </dbReference>
    <dbReference type="OMA" id="GNEARVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="11956" checksum="4F6B79E7C3778A8A" modified="2017-01-18" version="1">MNLSSVHTYAVGHLAEDPPKKPSIDTIIGGIAPDWGPFATLGSEARVMVEVIMALAIILCLGIAAWGAAKQRIGATAMRDSFGAEQGKGLIIAGLTGVFIIGSLGTLFTIVYGMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N847</accession>
    <name>A0A1E7N847_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282032.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6452"/>
    <dbReference type="EnsemblBacteria" id="ARF78684">
        <property type="protein sequence ID" value="ARF78684"/>
        <property type="gene ID" value="B6264_06930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36870">
        <property type="protein sequence ID" value="OEV36870"/>
        <property type="gene ID" value="HS99_0026755"/>
    </dbReference>
    <dbReference type="OMA" id="CKLGFGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="30393" checksum="7529FC4B722F6BEB" modified="2017-01-18" version="1">MSNASSKQIAVIGAGLMGAGIAQVSAQAGHPVVLRDVTEEALQRGLAGIRASYEKFVSKGRLSAEDAEAALGRITTTTDLGAVAEADIVVEAVFENLEVKEGVFRELDKLAKDGAVLASNTSAIPITRIAAVTQRPESVVGVHFFSPVPMMKLVELVRGYKTSDGTLAAARAYAEGVGKEVVVVNRDVAGFITTRLITALVVEAAKLYESGVATAEDIDTACRLGFGHAMGPLQTADLTGVDILLHAAHNIYTETKDEKFAAPEIMARMVTAGDLGRKSGRGFYPYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N857</accession>
    <name>A0A1E7N857_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366571.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6454"/>
    <dbReference type="EnsemblBacteria" id="ARF78682">
        <property type="protein sequence ID" value="ARF78682"/>
        <property type="gene ID" value="B6264_06920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36872">
        <property type="protein sequence ID" value="OEV36872"/>
        <property type="gene ID" value="HS99_0026765"/>
    </dbReference>
    <dbReference type="OMA" id="QAYFHHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="762" mass="77215" checksum="AB125BFCB8AFA7C4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D9</accession>
    <name>A0A1E7N8D9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286975.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6803"/>
    <dbReference type="EnsemblBacteria" id="ARF78599">
        <property type="protein sequence ID" value="ARF78599"/>
        <property type="gene ID" value="B6264_06460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36951">
        <property type="protein sequence ID" value="OEV36951"/>
        <property type="gene ID" value="HS99_0027235"/>
    </dbReference>
    <dbReference type="OMA" id="YHAHDPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1019" mass="109941" checksum="11235317E9902FDC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E1</accession>
    <name>A0A1E7N8E1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6824"/>
    <dbReference type="EnsemblBacteria" id="ARF82667">
        <property type="protein sequence ID" value="ARF82667"/>
        <property type="gene ID" value="B6264_06560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36965">
        <property type="protein sequence ID" value="OEV36965"/>
        <property type="gene ID" value="HS99_0027130"/>
    </dbReference>
    <dbReference type="OMA" id="AVLCVEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="16050" checksum="08A723EA03F2BFAD" modified="2017-01-18" version="1">MVDIGCGLGYLVRWLAATGKHRPAVRAALRGTAVGALLLLASALTAVMLLLTAPDHARTYATLAAGGNGFLLPLIPYAAAVLLSLAAYFTLPFRAGTLAMVIGLGPLTLLRPLAVAAGCLGAVLNGGGASGLLVGAVAGGAVLCVEPLVHRRWYRRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E7</accession>
    <name>A0A1E7N8E7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="10" type="ORF">HS99_0026925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6487"/>
    <dbReference type="EnsemblBacteria" id="ARF82672">
        <property type="protein sequence ID" value="ARF82672"/>
        <property type="gene ID" value="B6264_06760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36961">
        <property type="protein sequence ID" value="OEV36961"/>
        <property type="gene ID" value="HS99_0026925"/>
    </dbReference>
    <dbReference type="OMA" id="FGMKWMM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="730" mass="82121" checksum="FE553E8B90BE702E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E8</accession>
    <name>A0A1E7N8E8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="8" type="ORF">HS99_0027220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286981.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6807"/>
    <dbReference type="EnsemblBacteria" id="ARF78602">
        <property type="protein sequence ID" value="ARF78602"/>
        <property type="gene ID" value="B6264_06475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36949">
        <property type="protein sequence ID" value="OEV36949"/>
        <property type="gene ID" value="HS99_0027220"/>
    </dbReference>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="51943" checksum="C170F9625A4C941B" modified="2017-01-18" version="1">MTELIRFTAAETAGAIAKGEVSAVEVAQAHLDRIEAVDKKVNAFLHVDTEGALAAARAVDEKRAKGEELGPLAGVPLALKDVFTTKGIPTTCGSKMLEGWIPPYDATLTTRLKDAGVVILGKTNMDEFAMGSSTENSAYGPTGNPWDLTRIPGGSGGGSAAALAAFEAPLAIGTDTGGSIRQPGAVTGTVGVKPTYGSVSRYGLVAFSSSLDQGGPCARTVLDAALLHEAIAGHDPLDSTSIDAPVPAVVEAAKMRDVRGMRIGVVKEFAGEGYQTGVMQRFDESVELLRELGAEVVEVSCPSFTLALPAYYLIAPSECSSNLARFDAMRYGLRVGDDGSRSAEEVTALTREAGFGDEVKRRIILGTYALSSGYYDAYYGSAQKVRTLISRDFDSAFAGVDVLVSPTTPTTAFPIGERADDPMAMYLADLCTIPSNLAGNAAMSLPVGLAPEDNLPVGLQIIAPAMADDRLYRVGGAVEAALNDKWGHTLLEEVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H8</accession>
    <name>A0A1E7N8H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557221.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene135"/>
    <dbReference type="EnsemblBacteria" id="ARF81734">
        <property type="protein sequence ID" value="ARF81734"/>
        <property type="gene ID" value="B6264_25075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36992">
        <property type="protein sequence ID" value="OEV36992"/>
        <property type="gene ID" value="HS99_0003940"/>
    </dbReference>
    <dbReference type="OMA" id="YQGSGEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="9180" checksum="49F8231DF24C4284" modified="2017-01-18" version="1">MTWSWEYLPSEQHVTAGCPAGFLTAVEERAAELVRAAEVLYLDGTSYQGSGEPMRHLDVAGGLLAYYVVPRLELVVVCQLTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N923</accession>
    <name>A0A1E7N923_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000652.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6851"/>
    <dbReference type="EnsemblBacteria" id="ARF82670">
        <property type="protein sequence ID" value="ARF82670"/>
        <property type="gene ID" value="B6264_06705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36963">
        <property type="protein sequence ID" value="OEV36963"/>
        <property type="gene ID" value="HS99_0026985"/>
    </dbReference>
    <dbReference type="OMA" id="GKGVWFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15517" checksum="9E3BC7759C578A86" modified="2017-01-18" version="1">MYSGRLCDPSAPNEVRLPSRPESGPVARRLVLNVLESWDLHQHLEAGELLTSELVSNAVRHAAGRTIGLEVSRKPGWLRIEVRDSSRALPCMILAEAKPVNERGRGLRIVDDLADRWGADLLPRGKGVWFELKIRERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N943</accession>
    <name>A0A1E7N943_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385552.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37216">
        <property type="protein sequence ID" value="OEV37216"/>
        <property type="gene ID" value="HS99_0005270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="18625" checksum="125DE84B3F24D7B9" modified="2017-01-18" version="1">MRPTCQDPLVKHVTYRLQPAQIRRQWIFSALFLAQGAYLLYRGSLVPVDVRTAAAMAFGVLLIVGGLLQVRGAFSSVSFDEREIWWTGALGSRKRFAWADITNVEVGKNRNRPDSGDVVRVTHREHGDSKLPAVIGMPGAWRDPDFETKAAHVIATWRAATAMPEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N990</accession>
    <name>A0A1E7N990_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0005460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737851.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1321"/>
    <dbReference type="EnsemblBacteria" id="OEV37249">
        <property type="protein sequence ID" value="OEV37249"/>
        <property type="gene ID" value="HS99_0005460"/>
    </dbReference>
    <dbReference type="OMA" id="RHHYYRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198900" evidence="5">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="47"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="146"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24838" checksum="1F31E9754C619B29" modified="2017-01-18" version="1">MHLDAVTSMVKSISVAGSASSTAPASDDMPTLLQRAGGGDETAFETLYQAVAGPVYGVALRTLRSLAHAEEVAQEVLLEVWRTAPCYRPERGSVMAWVLTIARRRAVDRVRSVRASTERDLRVVVRNLSESESDPPEVQAVRSLDRQRVRSALAELSALQREAVVLAYFGGYTQREIAHRVGVPLGTVKTRIRDGLIRLRAVLTPAGDCPGVGELSAGPLLGPCRAAGARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y3</accession>
    <name>A0A1E7N9Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nipsnap superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386015.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7962"/>
    <dbReference type="EnsemblBacteria" id="OEV37492">
        <property type="protein sequence ID" value="OEV37492"/>
        <property type="gene ID" value="HS99_0026095"/>
    </dbReference>
    <dbReference type="OMA" id="DPDRFVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20996" checksum="DDD22BFCB53DF2E3" modified="2017-01-18" version="1">MSLVVELRRYTLHPGARETLIELFEREFVTGQEAVGITVGGRFRDLDDPDRFVWLRAFPSMAERRRALEAFYYGPVWREHRDAANATMIDSDDVLLLRGPGFALPTDGRELRATVCHPADAAAFDTWAARHLGPEHALHRTEHAENDFPQLPVRTGEDARLWFGAVEEPPPWPHQHLRLEPVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD0</accession>
    <name>A0A1E7NAD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280697.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1715"/>
    <dbReference type="EnsemblBacteria" id="ARF79898">
        <property type="protein sequence ID" value="ARF79898"/>
        <property type="gene ID" value="B6264_14180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37641">
        <property type="protein sequence ID" value="OEV37641"/>
        <property type="gene ID" value="HS99_0025395"/>
    </dbReference>
    <dbReference type="OMA" id="YLRRMLY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="28892" checksum="AD0A21BC243DFA31" modified="2017-01-18" version="1">MTDPVNHTILLLDIEQFGRRDDVEQAFMRRMLYSVLHETLRSAGVEPADQRLEDRGDSVMALISPTVPKPRLLHALVNETPALLHANNRLAAAEARVRLRIVLASGEVAVQELGGALGGAVGWDLNQAFRLLDSAALREALRHRNGPCVLGVSDALYQGIVRHGHGGLLPEAFHRVTVQGKEGDFTAWLHGEPAPAPSPPPSAAPAAAAAPTPGPAPAPPAAQAPDPAESRAPATFQFLGGSPTFGGNLIGGDQHIVSGGEVHGDVNTGNTVGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD4</accession>
    <name>A0A1E7NAD4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="7" type="ORF">HS99_0025500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280740.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1694"/>
    <dbReference type="EnsemblBacteria" id="ARF79917">
        <property type="protein sequence ID" value="ARF79917"/>
        <property type="gene ID" value="B6264_14290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37660">
        <property type="protein sequence ID" value="OEV37660"/>
        <property type="gene ID" value="HS99_0025500"/>
    </dbReference>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="701" mass="76892" checksum="9971A7A943C94BE1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK9</accession>
    <name>A0A1E7NAK9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 13">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="14" type="ORF">HS99_0025835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 12">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 13"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280857.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000767.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1627"/>
    <dbReference type="EnsemblBacteria" id="ARF79979">
        <property type="protein sequence ID" value="ARF79979"/>
        <property type="gene ID" value="B6264_14625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37721">
        <property type="protein sequence ID" value="OEV37721"/>
        <property type="gene ID" value="HS99_0025835"/>
    </dbReference>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 13" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="344"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="391"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV37721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="500" mass="52549" checksum="70E6B140B8821E8D" modified="2017-01-18" version="1">MSYNAAGVPEKFAMLGLTFDDVLLLPGASEVLPNQVDTSSRVSRNVRVNIPLLSAAMDKVTEARMAIAMARQGGVGVLHRNLSVEDQANQVDLVKRSESGMVTDPITVGPDTTLAEADALCAKFRISGVPIADEAGKLLGIVTNRDMAFESDRSRQVREIMTPMPLITGKVGISGEDAMALLRRHKIEKLPLVDDEGRIKGLITVKDFVKAEQYPNAAKDAEGRLLVGAAVGASAEAFDRAQALVEAGVDFLVVDTSHGHSHNALAWIEKIKSAVRVDVVGGNVATRDGAQALIDAGVDGVKVGVGPGSICTTRVVAGIGVPQITAIYEAAQACQAAGVPVIGDGGLQYSGDIGKALAAGADTVMLGSLLAGCEESPGELLFINGKQFKSYRGMGSLGAMQSRGQGRSYSKDRYFQAEVASDDKLVPEGIEGQVQYRGPLSAVLHQLVGGLRQTMGYVGAGTIAEMESKGRFVRITAAGLKESHPHDIQMTVEAPNYSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL6</accession>
    <name>A0A1E7NAL6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0025375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367153.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6235"/>
    <dbReference type="EnsemblBacteria" id="OEV37740">
        <property type="protein sequence ID" value="OEV37740"/>
        <property type="gene ID" value="HS99_0025375"/>
    </dbReference>
    <dbReference type="OMA" id="PCERLMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="90"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="34345" checksum="5769BA0EDC5E2D4C" modified="2017-01-18" version="1">MDPHTGRIHLAARQRGADATAIGQLVFQLPHFLCSLLVIGIISMFLAAPFNYLLIGAWIASGALVFHRPTEKLLARYLFRMRPALHSELTRLEPIWHQVTAKAGVSPETYDLWIEDHKAVNATAAAGHIVGVTRYALETLPDAQLAAVLAHELGHHRGGHAWATLLGYWYSMPARIAWAAFRIAAVIAFQIASVFSLLGALVVGLVSVVVVVAVALSFPPLLLVLVTPYLLAAVGRRSELRADVQAAELGFADAMIEVFHGFLRDEEQALAIAARENGGRAVRPGLGQRLLSSHPDTHTRIRRLEDWRAAAAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE9</accession>
    <name>A0A1E7NBE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Very short patch repair endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0024695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558087.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000665.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7571"/>
    <dbReference type="EnsemblBacteria" id="OEV37793">
        <property type="protein sequence ID" value="OEV37793"/>
        <property type="gene ID" value="HS99_0024695"/>
    </dbReference>
    <dbReference type="OMA" id="HDCYLFK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="17508" checksum="187E5D5C0D3726C1" modified="2017-01-18" version="1">MDAATWVAPEGSWASSAGRRRNMQAIRSRDTSPELALRSLVHAAGLRYRVGAKPLPGMRRTADLLFRPTRVAVFVDGCFWHACPEHFVRPKTNPSYWNEKIDRNVRRDRDTDTKLAEAGWLVLRFWEHEPPAECAALVVDAVRQRRAEATRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF2</accession>
    <name>A0A1E7NBF2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2084"/>
    <dbReference type="EnsemblBacteria" id="OEV38015">
        <property type="protein sequence ID" value="OEV38015"/>
        <property type="gene ID" value="HS99_0023980"/>
    </dbReference>
    <dbReference type="OMA" id="KRWNGVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11424" checksum="CBD83B56DD528A87" modified="2017-01-18" version="1">MALNRVFTLLGKRWTGMLLGVLNNGGPAYFSELRRAVPGISERMLSDRLTELAEAGLVVREVDPGPPLRVSYRLTEGGVALKPALTELAVWADRYLPESALRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ4</accession>
    <name>A0A1E7NBJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737828.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1995"/>
    <dbReference type="EnsemblBacteria" id="OEV38028">
        <property type="protein sequence ID" value="OEV38028"/>
        <property type="gene ID" value="HS99_0024425"/>
    </dbReference>
    <dbReference type="OMA" id="ETKHPTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="12"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="29275" checksum="FAF322BC0AAB76B7" modified="2017-01-18" version="1">MPLAAARTAPSVQVIAHRGSSHALPEHTLAAYRRALDEGADAVECDVRVTADGHLVCVHDRRIGRVSNGRGTVSAMTLAELEAYDFGAWKTGRPSTDPELRGVLRLERLLELVADCGRPVDLAIETKHPVRFRGRVEAELLRMLERFKIGATREGDRPSARIMSFSSIALDRVAAAAPEYGRVFLIERMLPLLGQLRPGRPLPGGAGIAGPGIELIKARPQLVPRLRELGHEVHVWTVDEPADVELCLELGVSAIITNRPAEVLAQLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBN9</accession>
    <name>A0A1E7NBN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000688.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82801">
        <property type="protein sequence ID" value="ARF82801"/>
        <property type="gene ID" value="B6264_12910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38109">
        <property type="protein sequence ID" value="OEV38109"/>
        <property type="gene ID" value="HS99_0023195"/>
    </dbReference>
    <dbReference type="OMA" id="AFMFADW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="573" mass="61975" checksum="45EE8D9BEDE6CBF5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU8</accession>
    <name>A0A1E7NBU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554372.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene459"/>
    <dbReference type="EnsemblBacteria" id="ARF78854">
        <property type="protein sequence ID" value="ARF78854"/>
        <property type="gene ID" value="B6264_07930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38162">
        <property type="protein sequence ID" value="OEV38162"/>
        <property type="gene ID" value="HS99_0023525"/>
    </dbReference>
    <dbReference type="OMA" id="VTHMTPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="77302" checksum="AFA3AB9A8A023D78" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC14</accession>
    <name>A0A1E7NC14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0021980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386477.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000369.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3321"/>
    <dbReference type="EnsemblBacteria" id="ARF80263">
        <property type="protein sequence ID" value="ARF80263"/>
        <property type="gene ID" value="B6264_16300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38227">
        <property type="protein sequence ID" value="OEV38227"/>
        <property type="gene ID" value="HS99_0021980"/>
    </dbReference>
    <dbReference type="OMA" id="YYRVVRN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="35152" checksum="A9AFD101EE2DAB96" modified="2017-01-18" version="1">MTAVAAEPTDPDSPVGRADPADPTGRPRATGRGRLVLARLLAARGAVAGAVLILLLFALAFGGPYLTPWDYAAPDFSALHQPPSAEHWFGTNGVGQDVFAQTVRGLQKSLIIGLLVALFSTVLASVVGACAGYFGGWADRALMFLVDLLLVFPSFLIITIVSSRLKSAGWIAFVLLLALFNWMITARVVRSMTLSLREREFVRAARFMGVRPLRIISRHILPNVASFLIIDATIAVGGAVMSETALSYFGFGVKAPDVSLGTLLAAGTSEAPVFPWMFYFAAGLLVLFVLAVNLVGDGLRDALDPTAGGAPRRSRRSPRSRRSWRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC97</accession>
    <name>A0A1E7NC97_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="5" type="ORF">HS99_0022665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283973.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4139"/>
    <dbReference type="EnsemblBacteria" id="ARF80150">
        <property type="protein sequence ID" value="ARF80150"/>
        <property type="gene ID" value="B6264_15610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38326">
        <property type="protein sequence ID" value="OEV38326"/>
        <property type="gene ID" value="HS99_0022665"/>
    </dbReference>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="40895" checksum="31E6E340361E4794" modified="2017-01-18" version="1">MAAVDPSEELKNLDTTMGSIEAVLDLDKIRADIAVLEEEAAAPTLWDDVANAQKVTSRLSFLQGELRRVEGLRGRIDDLGVLFELAEAEDDADTRVEAEAELVSLQKAVEELEVRTLLSGEYDAREALINIRAEAGGVDAADFAEQLMRMYLRWAERHGYPTEVYDTSYAEEAGIKSATFTVKAPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEQSDHVDIDEGDLRVDVYRASGPGGQGVNTTDSAVRITHLPTGIVVSCQNERSQIQNKASAMNVLQAKLLERRRQEEKAAMDALKDSGSSWGNQMRSYVLHPYQMVKDVRTAYEAGNPQAVLDGDIDGFIEAGIRWRKQRETSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD7</accession>
    <name>A0A1E7NCD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3335"/>
    <dbReference type="EnsemblBacteria" id="OEV38345">
        <property type="protein sequence ID" value="OEV38345"/>
        <property type="gene ID" value="HS99_0022060"/>
    </dbReference>
    <dbReference type="OMA" id="FVIIAMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="38562" checksum="CCAB8195D5CF15D2" modified="2017-01-18" version="1">MPRTGDSATNRWTRMHAALRWWPIAPLITLLVAPYSALPVPGLLDGPLGSPGSLQLIALCLLYGALATGYDLLLGRTGLLSFGHALYFATGLYGTDLGMLELRLPFAAAAAFGVACTALLALLLGSVSLRVTGIGFSMVTLAFAQAGAILVQRNPGGVTGGEEGRSAPAELLPSGLLGIENTANLYWIAVGYLVLTVAAVHWAVHSPAGRVWEGIKENERRVEVLGLRPYGYKLVAFVLSGALAGVGGVVYLLLTGGATPQAAGSDATLALLVMVVLGGTGTRWGPLLGGVLYTWAGHRLGDLANSNAVADLPAVLRVPLSQPLFLLGALFVAVVYLLPGGLAGLPARIRAARSARSVRTPTGVPAARPTGGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF9</accession>
    <name>A0A1E7NCF9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucanase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0022105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558061.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000401.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1756"/>
    <dbReference type="EnsemblBacteria" id="ARF80243">
        <property type="protein sequence ID" value="ARF80243"/>
        <property type="gene ID" value="B6264_16175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38348">
        <property type="protein sequence ID" value="OEV38348"/>
        <property type="gene ID" value="HS99_0022105"/>
    </dbReference>
    <dbReference type="OMA" id="NVDSIVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="entry name" value="PTHR34876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="SSF51989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015018714" description="Glucanase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="36662" checksum="D741123859A3AB93" modified="2017-01-18" version="1">MGRAGTFRSARASRWAALAVAGLVLTVPGCSGSGGAGGTSGARSASPTSTPAGSPAAGPVVLNQLPGQAFYVSDRTNAAQQVGVLRSQGRSAEADTLLRIAAQPSSQWLGDQGAREIADQVSRRATEAGRTAVFVAYDIPHRDCGQYSAGGAPDAASYRSWITGVAEALGDRKAWVVLEPDAVAHTLDSCGVKGDLAAERYGLLAFAVQELKKRPNVRVYLDAGNPGWAQDPEDLAAALRKSGIAVADGFAVNVANFYPTDRNAAYGNRLSAALGGKHFVIDTSRSGNGSAGADSWCNPPGRALGEAPTTETGRPGVDAYLWIKNPGESDGQCGRGEPPAGQFWLPYALGLAQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN3</accession>
    <name>A0A1E7NCN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290738.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000650.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1753"/>
    <dbReference type="EnsemblBacteria" id="ARF80241">
        <property type="protein sequence ID" value="ARF80241"/>
        <property type="gene ID" value="B6264_16160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38243">
        <property type="protein sequence ID" value="OEV38243"/>
        <property type="gene ID" value="HS99_0022120"/>
    </dbReference>
    <dbReference type="OMA" id="MDGVLIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27813" checksum="A6B8FBC4E427AD73" modified="2017-01-18" version="1">MADRKPIESWLTDMDGVLIHEGTPIPGAEEFLRRLRESGKPFLVLTNNSIYTPRDLSARLAGMGLEVPEECIWTSALATAKFLAGQRPNGTAYVIGEAGLTTALYQAGYVLTDNNPDYVVLGETRTYSFEALTKAIRLINQGARFICTNPDETGPSTEGVLPATGSVAALITKATGVEPYFVGKPNPLMMREALNTAGAHSESAVMIGDRMDTDIVAGMEAGMETVLVLTGLTSAADVERFPYRPSRVVKSIADLVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ3</accession>
    <name>A0A1E7NCQ3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000326.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1730"/>
    <dbReference type="EnsemblBacteria" id="ARF80219">
        <property type="protein sequence ID" value="ARF80219"/>
        <property type="gene ID" value="B6264_16030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38263">
        <property type="protein sequence ID" value="OEV38263"/>
        <property type="gene ID" value="HS99_0022240"/>
    </dbReference>
    <dbReference type="OMA" id="WFAEYQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27098" checksum="F6DBEB6816512F7D" modified="2017-01-18" version="1">MSATTYAVSDSLTMLRRNLKRAQRYPAMTFSVVVMPVMMLMLFNYAFGGALGAGIGGGSYIDYVTPGIVLMTATAGSVATAVGVCVDMTEGIVNRFRTMAISRSAFLTGHVVGSVIQTLVALVLVIGAAFAMGFRSSAGPVEWLAAAGLLLFVTLTLTWISAGIGLVSKTPESASNTPLPLTFLPFIGSAIVPPDSMPTVLRWFAEYQPFTPIIETLRGLLMGTGIGNSGWIALAWCTGLTLLGYVWSRSVFYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW6</accession>
    <name>A0A1E7NCW6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glsA</name>
        <name evidence="6" type="ORF">HS99_0020995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283228.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene255"/>
    <dbReference type="EnsemblBacteria" id="ARF83116">
        <property type="protein sequence ID" value="ARF83116"/>
        <property type="gene ID" value="B6264_28060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38525">
        <property type="protein sequence ID" value="OEV38525"/>
        <property type="gene ID" value="HS99_0020995"/>
    </dbReference>
    <dbReference type="OMA" id="RPRNPFI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="31995" checksum="138144FB557101E1" modified="2017-01-18" version="1">MDYPVLLEAAEAAARATTGRGHVADYIPALAEADPEAFGMAVATVDGELYGVGDWEQPFSVQSVSKLFSLALALAYSSDGGEELWRGVGREPSGNPFNSLVQLETEHGIPRNPFINAGALVVTDRLQSLTGDASGAVREFLRRESGNPLLDTDPVVAASEAAHGHRNAALAHFIASHGNLQNPVETVLEHYYAHCAIATSCRDLVLAGAFLARYGVRTDGTRLMTRSEAKRINAVLLTCGTYDAAGEFAFRVGLPGKSGVGGGVLAILPGRAAICAWGPRLDQAGNSVAAVTALDTLTTLSGCSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX4</accession>
    <name>A0A1E7NCX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386823.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000526.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene696"/>
    <dbReference type="EnsemblBacteria" id="ARF77573">
        <property type="protein sequence ID" value="ARF77573"/>
        <property type="gene ID" value="B6264_00320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38550">
        <property type="protein sequence ID" value="OEV38550"/>
        <property type="gene ID" value="HS99_0019905"/>
    </dbReference>
    <dbReference type="OMA" id="CASDFEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="16009" checksum="A4A0D4FD61ADC4D6" modified="2017-01-18" version="1">MAELDSLEASAEAGLIAEWRELLARHAAAVCALDRELGEKYGLGMSEFEVLERLVEGCEAEARHALRASELASIVHLSQSALSRLIARLEKAGLVTREMCPSDRRGIMIALTEAGRERYEQARPLHRAVLGLTLGGRFAPLCGDPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND34</accession>
    <name>A0A1E7ND34_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551514.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene674"/>
    <dbReference type="EnsemblBacteria" id="ARF77593">
        <property type="protein sequence ID" value="ARF77593"/>
        <property type="gene ID" value="B6264_00430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38568">
        <property type="protein sequence ID" value="OEV38568"/>
        <property type="gene ID" value="HS99_0020015"/>
    </dbReference>
    <dbReference type="OMA" id="EVWTVLL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="637" mass="64008" checksum="EBBF390DEAD2E7A0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN5</accession>
    <name>A0A1E7NDN5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">HS99_0019070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7366"/>
    <dbReference type="EnsemblBacteria" id="OEV38775">
        <property type="protein sequence ID" value="OEV38775"/>
        <property type="gene ID" value="HS99_0019070"/>
    </dbReference>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41122" checksum="917884611C089B7B" modified="2017-01-18" version="1">MRWLTAGESHGPALVATLEGLPAGVPVTTDVVADALARRRLGYGRGARMKFEQDEVTFLGGVRHGLTMGSPVAVMVGNTEWPKWEQVMSADPVDPEVLAGLARNEALTRPRPGHADLAGMQKYSIDEARPILERASARETAARVALGAVARAYLREVAGIEIVSHVVELAAAKAPAGVVPLPSDEARLDADPVRCLDADASKAMVAEIDQAHKDGDTLGGVVEVLAYGVPVGLGSHVHWDRRLDARLAAALMGIQAIKGVEVGDGFELARVPGSKAHDEIVPTPEGVKRTSGRSGGTEGGLTTGEVLRVRAAMKPIATVPRALQTLDVRTGEPAKAHHQRSDVCAVPAAGIVAEAMVALVLADAVSEKFGGDHVSETRRNVQGYLDNLIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC1</accession>
    <name>A0A1E7NEC1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557365.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4360"/>
    <dbReference type="EnsemblBacteria" id="ARF83223">
        <property type="protein sequence ID" value="ARF83223"/>
        <property type="gene ID" value="B6264_30245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38995">
        <property type="protein sequence ID" value="OEV38995"/>
        <property type="gene ID" value="HS99_0017975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15351" checksum="6122C26D7E92849A" modified="2017-01-18" version="1">MPETTATMLLTDAYTWYSTGLRDLVRELLDEAGLDINEDTVDDLCGELWLHAAEFTATRCLSFTEVLDLLDWSADVLVNRLRNQPAPILAGRLGTAADPADVAEVVTNAVGETDYRPAARPQRPATTSFAFAHLTALRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ9</accession>
    <name>A0A1E7NEJ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0018590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4087"/>
    <dbReference type="EnsemblBacteria" id="OEV39094">
        <property type="protein sequence ID" value="OEV39094"/>
        <property type="gene ID" value="HS99_0018590"/>
    </dbReference>
    <dbReference type="OMA" id="HHTLRAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="12006" checksum="A3EC5D77B400AB64" modified="2017-01-18" version="1">MARPSSYPPELRRRAVRMVAEVLGDYPNESAALRAVAEKLGIGSAETLRNWVRRDQVDSGQRPGTTTEESAQIKAMKKEIAELKRANEILKAAASFFAAELDRPHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEM0</accession>
    <name>A0A1E7NEM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386386.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000342.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83321">
        <property type="protein sequence ID" value="ARF83321"/>
        <property type="gene ID" value="B6264_30835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39088">
        <property type="protein sequence ID" value="OEV39088"/>
        <property type="gene ID" value="HS99_0018555"/>
    </dbReference>
    <dbReference type="OMA" id="YGAVHER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="16346" checksum="584657F5143F31CA" modified="2017-01-18" version="1">MASVHKEFVIDALPEAVWAVLSDYGAVHERLAPGFVIDTRLSSDTRTVTFADGTIVLERLVDLDHETKRVAYTVVGGSLHPSHHHASMQALPEAEGRTRFVWHIDVLPDTLAAPIAEFVEHGSAVIRRTLEASTTPKREPARTPPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER6</accession>
    <name>A0A1E7NER6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558339.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000865.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83352">
        <property type="protein sequence ID" value="ARF83352"/>
        <property type="gene ID" value="B6264_31020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39125">
        <property type="protein sequence ID" value="OEV39125"/>
        <property type="gene ID" value="HS99_0018750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7359" checksum="7A473564DE792887" modified="2017-01-18" version="1">MTNSERRPLWRPFSESPADPAAVQASPAARLTAVERAPFLEPVETPTPRAVPGTRRPLGPGALATPAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NES3</accession>
    <name>A0A1E7NES3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas1</name>
        <name evidence="2" type="ORF">HS99_0017870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385785.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4337"/>
    <dbReference type="EnsemblBacteria" id="ARF83205">
        <property type="protein sequence ID" value="ARF83205"/>
        <property type="gene ID" value="B6264_30135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39135">
        <property type="protein sequence ID" value="OEV39135"/>
        <property type="gene ID" value="HS99_0017870"/>
    </dbReference>
    <dbReference type="OMA" id="YYLQHCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09719">
        <property type="entry name" value="Cas1_I-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033641">
        <property type="entry name" value="Cas1_I-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33433" checksum="228D9C2C45A2966E" modified="2017-01-18" version="1">MLPRIADSLSFLYLDIVRVVQDDTGVCAEITSVDRGTETVYLPTAALGCVLLGPGTSITARALATLARHGTTVVIAGAGGVRCYAAVLPDSLTTVWLERQVRVWADDTSRLAVATAMYEQRFGRGTAPAGSNFAQLRGFEGDRVKALYRLLAQQHRIGRFRRNYDPKSWDTQDPVNLALSSANTCLYGIVHAAILALGCSPALGFIHSGNQQAFVYDIADLYKAELTIPLAFSLHSSPYPEAEARRGFRDGLQLFRLLPRIVADIQRLLAPEQQMATPDPEEQLVDLWDPVSGVLPGGVNYSTEQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF39</accession>
    <name>A0A1E7NF39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3570"/>
    <dbReference type="EnsemblBacteria" id="ARF82443">
        <property type="protein sequence ID" value="ARF82443"/>
        <property type="gene ID" value="B6264_29395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39245">
        <property type="protein sequence ID" value="OEV39245"/>
        <property type="gene ID" value="HS99_0000530"/>
    </dbReference>
    <dbReference type="OMA" id="IFADAWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20065" checksum="89D2A9F21A22846F" modified="2017-01-18" version="1">MTVNEQRGVPAEVLAAERLAARLGFGKSCTREVGRLLALAAAAKPGGTVAESGTGAGVGTAWLRSGLGPGARLVTVERDGELARRSAGLFADDARVRVLHGDWRLLEEHAPFDVFFCDGGGKRDDPDRVVELLAPGGLLLMDDFTPSPHWPPRFGGEVDGLRLHYLTHPALEATEVLAAPGGSAVLAVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK3</accession>
    <name>A0A1E7NFK3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556287.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5104"/>
    <dbReference type="EnsemblBacteria" id="OEV39467">
        <property type="protein sequence ID" value="OEV39467"/>
        <property type="gene ID" value="HS99_0001865"/>
    </dbReference>
    <dbReference type="OMA" id="QMPMIFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="47346" checksum="7F747CC8E108D17E" modified="2017-01-18" version="1">MTTAVDARPADLRGWDPEDEEFWQRAGARIARRNLVFSVLSEHIGFSVWSLWSVLVLFLGPQYHIDTAGKFTLTALPTALGALLRLPYTFAVARFGGRNWTVISALLLLLPTALAALVLRPGVSYGTLLAVACVAGVGGGNFASSMANINAFYPHRLKGWALGVNAGGGNLGVPAVQLLGLLVLATAGAAHPRLLPLLYLPLIVLAAAGAWWRMDNLAVSSKGEGRALREVARDPYGWAVSTLYIGTFGSFIGFGFAFGQVLQVQFHDRFDTPVKAAALTFLGPLLGSLLRPVGGRLADRWGGAKVTLATFAAMGAGTAVVLVASRAGSLPLFLAGFIALFVLSGIGNGSTYKMIPAHYQGRARAAVAAGAETDAAEADSRRRSAALIGLAGAIGAFGGVIVNLAFRQSFQASHNGDAAYLGFLAAYLACSALTWLVWLRPGARAGLVRQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN4</accession>
    <name>A0A1E7NFN4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285875.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5083"/>
    <dbReference type="EnsemblBacteria" id="OEV39482">
        <property type="protein sequence ID" value="OEV39482"/>
        <property type="gene ID" value="HS99_0001960"/>
    </dbReference>
    <dbReference type="OMA" id="VWSGIES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="7"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="45939" checksum="19412371401BA83B" modified="2017-01-18" version="1">MTVGAPDVVVVGAGVIGSAIALELARGGRQVTVVDKAGAVGHGSTSASSAVIRFNYSTFAGVATAWEAQHLWTSWAAHLRLAGHRPLAAFRRTGAVLLDSPTVAPSATAALFDRAGVPYERWDAPTLRRRLPGIDPGRYWPPKPVDDDAFFADPSGELGALFTPDAGYVDDPQLAAQNLADAAAELGARFLFHHTVVAVDRYADRVAGIRLADGTRIAAPVVVNATGPWSGGLNRLAGVGGDFTIGVRPLREEVHQVAAPEGRPAEPFPLVADLDLGTYIREAPGGHLLVGGTEPDCDPHEWIDDPDGADPRPTVRRFRTQVTRAARRFPAIGVPNRPLGAAGVYDVADDWTPIYDRTGLDGYYVAMGTSGNQFKNAPLVGRFLAALIDAVEAGHDHDGDPVRHHGEHTGNVIDLGAFSRRRPIRSGAARTVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG10</accession>
    <name>A0A1E7NG10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387278.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000789.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2774"/>
    <dbReference type="EnsemblBacteria" id="OEV39636">
        <property type="protein sequence ID" value="OEV39636"/>
        <property type="gene ID" value="HS99_0002900"/>
    </dbReference>
    <dbReference type="OMA" id="ILVIDRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="270"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="522" mass="55413" checksum="5136C0E62D2C73CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG69</accession>
    <name>A0A1E7NG69_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550438.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2853"/>
    <dbReference type="EnsemblBacteria" id="OEV39700">
        <property type="protein sequence ID" value="OEV39700"/>
        <property type="gene ID" value="HS99_0003300"/>
    </dbReference>
    <dbReference type="OMA" id="WYQYYFH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="33073" checksum="3AB4F5409A3003C9" modified="2017-01-18" version="1">MTVTSHELHRVTTPVLEIAYHRTGERRRTTDAPVILLHGFPYDVRAYDEVARLVAEVGREVLVPYLRGYGPTRFLDGGTVRSGQQAALARDLVEFMDALGIERAVVAGYDWGGRAACAAAALWPERIDGLVAAGGYTVQDIARAMEPAAPEAERNLWYQYYFHSDRGRQGLEQNREELCGLLWRLWSPSWAAAGKAFAASAPSLHNPDFVEVSIHSYRHRYGLVEGDPRYQELEETLAGRPPIAAPTVVLVGEENGVIPAADQTGTDRFTGPCEVRTLPGVGHNVPQEAPEAFAEAVLSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL5</accession>
    <name>A0A1E7NGL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830147.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene557"/>
    <dbReference type="EnsemblBacteria" id="OEV39817">
        <property type="protein sequence ID" value="OEV39817"/>
        <property type="gene ID" value="HS99_0001515"/>
    </dbReference>
    <dbReference type="OMA" id="CLNYASI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10586" checksum="4DD5D9237AA24FAE" modified="2017-01-18" version="1">MPVPRLSLQTVARLSGVHPDLIRRFVALGLVEAERDASGELAFEPTAPAALARVQRLRTGLCLNYASIGLVLDLLDRISLLEAALRRAGTRSGTPPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGU1</accession>
    <name>A0A1E7NGU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550467.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2891"/>
    <dbReference type="EnsemblBacteria" id="OEV39868">
        <property type="protein sequence ID" value="OEV39868"/>
        <property type="gene ID" value="HS99_0003480"/>
    </dbReference>
    <dbReference type="OMA" id="WMFPNVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="28938" checksum="3CC9D98688B6ACE3" modified="2017-01-18" version="1">MTTPTAAPDSYYQRTGEHSYKPTAHAQGAWHPDEQHFSPVGGLIAHAIDRHRADRPADGLALARISYDILGLIALDELEITVETLRPGRTIELVEAVASVNGRAVVRARAWFLAEQDTGAVAGTHDERLPAPQEFESWAMDEQWGGGYIASVEVRRRSTAPGRAAAWLSTPLEIVAGERSSPHAAFIALVDTANGIAVREQPTAWMFPNTDLTIHFHRRPDGRWTGLDTSVSFGPSGHGVTSTVLHDVHGPVGRAEQILTVRPMPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SEP3</accession>
    <name>A0A176SEP3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0004095</name>
        <name evidence="10" type="ORF">HS99_0006310</name>
        <name evidence="8" type="ORF">HS99_0009355</name>
        <name evidence="11" type="ORF">HS99_0024555</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762</strain>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558454.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000316.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000148_gene569"/>
    <dbReference type="EnsemblBacteria" id="ARF78096">
        <property type="protein sequence ID" value="ARF78096"/>
        <property type="gene ID" value="B6264_03445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81706">
        <property type="protein sequence ID" value="ARF81706"/>
        <property type="gene ID" value="B6264_24905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81951">
        <property type="protein sequence ID" value="ARF81951"/>
        <property type="gene ID" value="B6264_26425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82501">
        <property type="protein sequence ID" value="ARF82501"/>
        <property type="gene ID" value="B6264_29785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34685">
        <property type="protein sequence ID" value="OEV34685"/>
        <property type="gene ID" value="HS99_0009355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37019">
        <property type="protein sequence ID" value="OEV37019"/>
        <property type="gene ID" value="HS99_0004095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37387">
        <property type="protein sequence ID" value="OEV37387"/>
        <property type="gene ID" value="HS99_0006310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37768">
        <property type="protein sequence ID" value="OEV37768"/>
        <property type="gene ID" value="HS99_0024555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="431" mass="47599" checksum="46463D2888C366A4" modified="2016-09-07" version="1">MSDVIVSAEAVEEVRPVELAPDVLDEQLIGQLVDRARAGGVKLTGEGGLLQQLTKRVLEAALEGEITDHLGYEKHDPAGAGSGNSRNGTRSKTVVTDVGPVEIDVPRDREGSFEPQIVRKRQRRLTGVDDMVLSLSARGLTHGEISAHLAEVYGANVSKQTISTITDKVIDGMAEWQNRPLDPVYPVIFIDCVHVKIRDGQVANRPIYVALAVTVEGTREILGLWAGDGGEGAKYWLHVLTEIKNRGVGDVCMVVCDGLKGLPDAIETVWPQAITQTCVVHLMRASFRYAARQDWDKISKALKPVYTAPTAKAAEDRFLEFQEAWGDKYPAIVKMWSDAWAEFVPFLQFDTEIRRVVCTTNAIESVNARIRKAVRARGHFPNEQAALKCVYMAIMALDPTGAGRKRWTTRWKAALNAFEITFDGRLSIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE5</accession>
    <name>A0A1E7MVE5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289552.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32401">
        <property type="protein sequence ID" value="OEV32401"/>
        <property type="gene ID" value="HS99_0017050"/>
    </dbReference>
    <dbReference type="OMA" id="ETIALWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14886" checksum="1FE0BF618EF15DCB" modified="2017-01-18" version="1">MTERPVPLRTDRPWQIVALAGASWLTPWALVRGDVNGETIALWFLLLALTVLPLSYRNPYLFRRTCRIVGGVLLGLQFVVSVPFLLLVLPLLVAFLPAGALLLLAGWKRSGPVRTGLAVTLAALPLVIVAGVLCHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR0</accession>
    <name>A0A1E7MVR0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6980"/>
    <dbReference type="EnsemblBacteria" id="OEV32520">
        <property type="protein sequence ID" value="OEV32520"/>
        <property type="gene ID" value="HS99_0016945"/>
    </dbReference>
    <dbReference type="OMA" id="DLIRCAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045428">
        <property type="entry name" value="EACC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19953">
        <property type="entry name" value="EACC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13030" checksum="547BB8F772AEEB2A" modified="2017-01-18" version="1">MRVADADRGAAASLLAWLRAEDELRGRVELEAAPPQPGSPGTRADVLTVAVGTGGAASGLTCALIAWVRRRGGETVVRVTRADGSSIELRATAVHGLEPDGVAELVREVGRSLADRPGPAALPDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS1</accession>
    <name>A0A1E7MVS1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1195"/>
    <dbReference type="EnsemblBacteria" id="OEV32532">
        <property type="protein sequence ID" value="OEV32532"/>
        <property type="gene ID" value="HS99_0017360"/>
    </dbReference>
    <dbReference type="OMA" id="PNMARMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="260"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35683" checksum="F516752ED7B37A84" modified="2017-01-18" version="1">MHDVLDADSERGRVYRCLVARPRARIQELAPAAGLDADTVLAVLRDLAEEGAAVAFGPAHSSDDRDHCWEALPPARVVETVLQRDAMRQATARRAGDELERLYRYARRDAGTYGALEVVEDRAEVMAASNRLQLAARHQVRVIDVPPYSGSSAHYLDQEALQRRRMAAGVVYRAIYQGCAFEDPVAGPNMARMVEAGEQARTLDEPPLKLAIGDEDLAIVTLPADGRDGVVSLLVRPSGLLNALAAVFETLWRLAVPATVAGVDLRIDERDRRILTLMASGATDDAIARRLGLGRRTVVRRVSTLLAHLGATTRFQAGVQAARRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW64</accession>
    <name>A0A1E7MW64_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3147"/>
    <dbReference type="EnsemblBacteria" id="OEV32659">
        <property type="protein sequence ID" value="OEV32659"/>
        <property type="gene ID" value="HS99_0015420"/>
    </dbReference>
    <dbReference type="OMA" id="TELFCAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16185" checksum="B6F8388F048B6EC7" modified="2017-01-18" version="1">MNDLTRAERPDAERSTGIARERLARRQEELLAALVAGGPVPPGFDPGQVRAQSTGLAAKRRDTTAKVAPDLPRLLGAQYGPLFLGYARTHPQTGGYRADARAFAAWVLTDGGPAATGHRRALEQWLRQSGEGAEQPPGPLARMRRALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE2</accession>
    <name>A0A1E7MWE2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TolB-like translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557628.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7813"/>
    <dbReference type="EnsemblBacteria" id="ARF78205">
        <property type="protein sequence ID" value="ARF78205"/>
        <property type="gene ID" value="B6264_04105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32750">
        <property type="protein sequence ID" value="OEV32750"/>
        <property type="gene ID" value="HS99_0015975"/>
    </dbReference>
    <dbReference type="OMA" id="WGPHRDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="36844" checksum="41D4817086CE50D9" modified="2017-01-18" version="1">MNPQNNRTRVIVLLVAVLVLGAVGTGAVLYAADRTARRDQPQSGGPAVTPGNVSLQAPSAGRQLLFRNMAWGPHRDEITTVPADHPDGPRTASGTQCLRFHAAAGTGICLQAEHGALEDTYRAVVLDDHLHQRRSFPAAGIPTRARVSPSGHLAAWTVFVSGDSYAGTNFSTRTSIVDVRDWNLRENLEDFAVIKDGRPYQAHDVNIWGVTFADDNTFYATLATSGQTHLVRGDLAARTLTTLHDNVECPSLSPDGTRIAYKKRVPGLSPDAPWRLYVLDLATGAETATAEQRNIDDQALWSDDGTLLYALPGDYGADLWTVPADGSGAARLVTKAAVAPAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP0</accession>
    <name>A0A1E7MWP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system, antitoxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000082">
        <property type="protein sequence ID" value="OEV32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000205.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000098_gene32"/>
    <dbReference type="EnsemblBacteria" id="ARF80366">
        <property type="protein sequence ID" value="ARF80366"/>
        <property type="gene ID" value="B6264_16930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32850">
        <property type="protein sequence ID" value="OEV32850"/>
        <property type="gene ID" value="HS99_0039840"/>
    </dbReference>
    <dbReference type="OMA" id="AADFMKQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8864" checksum="76ED14CB13830C46" modified="2017-01-18" version="1">MGKKQLNVRVDATTAEMARERAEQQGISMNQYIERLVQQDMGESGRAFIDAAAQFMKEYETAFLAEFGDSGELQDVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP4</accession>
    <name>A0A1E7MWP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000083">
        <property type="protein sequence ID" value="OEV32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553222.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000431.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4116"/>
    <dbReference type="EnsemblBacteria" id="ARF80133">
        <property type="protein sequence ID" value="ARF80133"/>
        <property type="gene ID" value="B6264_15495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32839">
        <property type="protein sequence ID" value="OEV32839"/>
        <property type="gene ID" value="HS99_0039900"/>
    </dbReference>
    <dbReference type="OMA" id="RVMKMPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="46420" checksum="4EB9AD64EC8BDF25" modified="2017-01-18" version="1">MALTGRTALIAALGALFVGLLLPSWVGIGAVTGAVLLAVLADLVLAAPVRSLRIVRGGATTVRLGDTASVELTVTNPSGRPLRALIRDAWAPSAWRPGTAETASRHTLAVPGGERRLAVSVLAPSRRGDHHAHRVTVRSLGPLGLAGRQGSHHVPWTVRALPPFHSRKHLPSRLARLRELDGRTSVLTRGQGTEFDSLREYLPGDDVRSIDWRASARRHTVAVRTWRPERDRHILVVLDTGRTSAGRVGDAPRLDAALDAALLLTALATRAGDRVDLLAHDARKRAAVIGSSPSEILPAFTNAMALLEPALHETDMRSLVSTALRMAPHRSLIVLLTGLDAAPVEDGLRPLLPLLTKRHEVVLASVADPHLDVLAAGRGTVEAVYGAAAAERTRADRRHTADRLTRHGVTVLDAPPAQIAPALADTYLALKAAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP8</accession>
    <name>A0A1E7MWP8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32857">
        <property type="protein sequence ID" value="OEV32857"/>
        <property type="gene ID" value="HS99_0039715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="16920" checksum="2F5BE507A22DD8C9" modified="2017-01-18" version="1">MPAARLSRSGQRGAIPAQPTGEPVTEAVQAAAAVQEAEPYTDPYQSYQQADPYSYDHYPAQQPAAAPYGSQGYDGQGYDGHQQQAYPQQGYEQQGYEQYPQEQYGYDPYQQQPGQPQQAWQPGRQGEPYYDPNDPGGTGHSPAHYPPHQHGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWT3</accession>
    <name>A0A1E7MWT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phospho-L-lactate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000399.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7MWT3"/>
    <dbReference type="EnsemblBacteria" id="ARF80116">
        <property type="protein sequence ID" value="ARF80116"/>
        <property type="gene ID" value="B6264_15385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32902">
        <property type="protein sequence ID" value="OEV32902"/>
        <property type="gene ID" value="HS99_0039570"/>
    </dbReference>
    <dbReference type="OMA" id="DLDTVMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33660" checksum="239BAF3B855F760F" modified="2017-01-18" version="1">MRIVALAGGIGGARFLRGLLAAVGPQDEITVIGNTGDDIHLYGLKVCPDLDTVMYTLGGGIHEEQGWGRADETWSIKAEMKEYGVGPEWFGLGDRDFATHLVRSQMLTAGYSLSQVTEALCVRWNPGVRLLPMSDDRVETHVRITDEQGTRAVHFQEYWVRLHAAVDAEAIIPVGADTAKPAPGVLEAIAEADVILFPPSNPVVSIGTILAVPGIREAVAAAPAPVVGLSPIIGGAPVRGMADKVLAAVGVEATAEAVALNYGPDLIDGWLVDTADEHAVAAVEAAGIACRAVPLLMTDVEATAEMARTALALAEQVRHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA7</accession>
    <name>A0A1E7MXA7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0014550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290643.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5609"/>
    <dbReference type="EnsemblBacteria" id="OEV33078">
        <property type="protein sequence ID" value="OEV33078"/>
        <property type="gene ID" value="HS99_0014550"/>
    </dbReference>
    <dbReference type="OMA" id="VSHYDLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198524" description="Aminopeptidase N" evidence="12">
        <location>
            <begin position="24"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="49"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="307"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="513" mass="55635" checksum="C0F3A42A8ACF6C21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXG8</accession>
    <name>A0A1E7MXG8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3418"/>
    <dbReference type="EnsemblBacteria" id="OEV33104">
        <property type="protein sequence ID" value="OEV33104"/>
        <property type="gene ID" value="HS99_0014725"/>
    </dbReference>
    <dbReference type="OMA" id="WNETHAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="161"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="41054" checksum="BBDFB7CDC389E7DB" modified="2017-01-18" version="1">MIVSLVYKVARKLLAVPAVLLRRDAAKDAELLVLRHENAVLRRQLTAPVRYEQADRLWFTALSSLIPRRRWAQVFPVTPGTLLAWHRRLIARKWDYSKQRGRPGRPPTASAVKALVLRLANENPRWGSRRIQGELVRLGHPIGATTVWEILTAAGIDPAPRRGGPTWREFLTAQAEGLIACDFVHIDLVDLRRVYALVFLEHGTRRLHVTGVTAHPTAPWAVQQARNLAVELDVRLDSLRFLIRDRDAKYTASFDAVFEAEDVEVIKSPPRAPRANAHCERVIGTLRREVLDHLLIWNETHARQVLNTYARHYNRHRPHQARGQLPPLAQEHPVPRAGLAAHRLLRARVLGGVINEYQYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL0</accession>
    <name>A0A1E7MXL0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">HS99_0013825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000901.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5755"/>
    <dbReference type="EnsemblBacteria" id="OEV33144">
        <property type="protein sequence ID" value="OEV33144"/>
        <property type="gene ID" value="HS99_0013825"/>
    </dbReference>
    <dbReference type="OMA" id="HGNAKSP"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="295"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="432" mass="45471" checksum="3223CB3C1CD4CA18" modified="2017-01-18" version="1">MLGGPWPASARPGPGADLLVGGVGLAEAAERFGTPLYVLDEGEVRSRARAYRQALPHAEVLYAAKAFLCSAMADWVAEEGLGLDVCSSGELWLAVSAGFPAQRILLHGNAKSPAELRLARRLRVGRIVIDGPAEIARLAALVAADTPQKVLVRVVPGIAAGHHAAVRTGVGGQKFGFPIEGGDAADAIARVLDQPGLELAGLHCHLGSQITEVEPYLRALDALVRLLAQVRERHGVELPELDLGGGHGIKYLPSDAEFDLAEFAVRLTDRLAVRCAEAGLEVPHLIVEPGRAIAGPAGVAVYRVLSVKHGADGHCFAAVDGGMGDNPRPALYGSQYSVRLVGRRSDADAMRADVVGRHCEAGDVLVRDAALPADLRPGDLLAVPAAGAYQLSMASGYNLVGRPAVAAVRDGRARLLIRRETVEDFRLREVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT2</accession>
    <name>A0A1E7MXT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000834.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5919"/>
    <dbReference type="EnsemblBacteria" id="ARF82081">
        <property type="protein sequence ID" value="ARF82081"/>
        <property type="gene ID" value="B6264_27230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33242">
        <property type="protein sequence ID" value="OEV33242"/>
        <property type="gene ID" value="HS99_0039180"/>
    </dbReference>
    <dbReference type="OMA" id="HTKHAVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="15229" checksum="42CA1602DF6205C8" modified="2017-01-18" version="1">MTTVTSPLTGQLVGLAGVPDPVFSGAMVGPGTAIDPVREPTEAVAPVDGVVVSMHPHAFVVVDADGHGVLTHLGIDTVQLNGEGFELLVNKGDTVTRGQAVIRWDPAAVEAAGKSPISPIVALEAATDSLVDVRENGDVLAGDKLFSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU3</accession>
    <name>A0A1E7MXU3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">HS99_0038940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283775.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000861.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4505"/>
    <dbReference type="EnsemblBacteria" id="ARF80405">
        <property type="protein sequence ID" value="ARF80405"/>
        <property type="gene ID" value="B6264_17160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33270">
        <property type="protein sequence ID" value="OEV33270"/>
        <property type="gene ID" value="HS99_0038940"/>
    </dbReference>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15243" checksum="4D7549D481981019" modified="2017-01-18" version="1">MSQRTLVLLKPDAVRRGLAGEIISRIERKAGWQLTAVELRTFDRETLEHHYAEHVGRPFYEPLLEFMTSGPSIAMIVEGEEVVKGIRMLAGATNPLEAGSGTIRGDYATITRENLIHASDSPESAEREIKIFFPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE3</accession>
    <name>A0A1E7MYE3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288734.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6594"/>
    <dbReference type="EnsemblBacteria" id="ARF80561">
        <property type="protein sequence ID" value="ARF80561"/>
        <property type="gene ID" value="B6264_18070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33457">
        <property type="protein sequence ID" value="OEV33457"/>
        <property type="gene ID" value="HS99_0012850"/>
    </dbReference>
    <dbReference type="OMA" id="PGPWILF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="100" mass="10823" checksum="891043E0871B440A" modified="2017-01-18" version="1">MYTQLADWHGPGAWILLVPLFWIAVVVLVITMLRRSVWRRYGACGFGTGFGAGAPGVVEHPLAVLGRRFAEGDIDAEEYRAKRAVLTEPTKDVPGGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP7</accession>
    <name>A0A1E7MYP7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0013415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000229.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5232"/>
    <dbReference type="EnsemblBacteria" id="ARF80653">
        <property type="protein sequence ID" value="ARF80653"/>
        <property type="gene ID" value="B6264_18635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33549">
        <property type="protein sequence ID" value="OEV33549"/>
        <property type="gene ID" value="HS99_0013415"/>
    </dbReference>
    <dbReference type="OMA" id="MNYYYAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PAP2_3" evidence="5">
        <location>
            <begin position="97"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="35969" checksum="F73ED334423C7F7B" modified="2017-01-18" version="1">MGEPTEIQRGDAARADAAHDGGSEAARASTARQPEGATRAAQSRTAALRNRVRDQRRSPARPRIWFELALIGISYWLYSIVRNAVPEQEAVAQRNARWIWDLEHHLGIAVEHSINHAVDSVGWLITGMNYYYATLHFIITIGVLVWLYRSHPGRYVAARTVLFVTTGIALVGFYFFPLAPPRLMTGGGFIDTVQAHHTWGSFASGPAAHVSNLYAAMPSMHIGWSMWCGLAIFFLARRTWVRVLGLMYPLATLTVIISTANHFWMDAVGGEICLTVGFLTARWLYHEWVYKLPQVPARETTDRPVTVPEQWSEPTVSSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR7</accession>
    <name>A0A1E7MYR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283866.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000587.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7041"/>
    <dbReference type="EnsemblBacteria" id="ARF82883">
        <property type="protein sequence ID" value="ARF82883"/>
        <property type="gene ID" value="B6264_17325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33577">
        <property type="protein sequence ID" value="OEV33577"/>
        <property type="gene ID" value="HS99_0012095"/>
    </dbReference>
    <dbReference type="OMA" id="VDWRKEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="22591" checksum="EECF43917DDB8CD3" modified="2017-01-18" version="1">MRLASVLALDRRAVAGLAILLLFAVGYAVQHFWLARPEAVAVPALAAASAVPEPGPSAADSPSGGGAGPPEASSGPGAGPAVVIDVGGRVHLPGLHTLPGGSRVADALRAAGGPLPETDTRGLNLARVLTDGEQILVGEQAQAPVPVQVPGGAGGLPGAGAPRTPVSLNRATLEQLDALPGVGPTLAQRILAYRASHGSFRSIDQLRQVSGIGARTFAELRPLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV9</accession>
    <name>A0A1E7MYV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286423.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1095"/>
    <dbReference type="EnsemblBacteria" id="ARF78980">
        <property type="protein sequence ID" value="ARF78980"/>
        <property type="gene ID" value="B6264_08670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33640">
        <property type="protein sequence ID" value="OEV33640"/>
        <property type="gene ID" value="HS99_0038555"/>
    </dbReference>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="31179" checksum="8A0353DFA45C089D" modified="2017-01-18" version="1">MPAKDDDRSTPPPLPQPLAVAVADSHTHLDMQAGTPAEGLARAASVGVTTVVQVGCDVPGSRWAAELAASYEQVHAAVALHPNEAPRIFLGDPDGWSGQQRPAGGRAALDEALAEIDALAALPQVLAVGETGLDYFRTGPEGVEIQKESFRRHIEMAKRHGKALVIHDRDAHEDVIAVLLAEGAPERTVFHCYSGDAEMAKVCAEHGWYLSFAGPVTFKANQPLRDALLATPLDRILVETDAPFLTPHPYRGRPNAPYLIPVTVRSMAATLGLHEDELSAAVAENTARAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ8</accession>
    <name>A0A1E7MYZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0038490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366740.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4945"/>
    <dbReference type="EnsemblBacteria" id="ARF80012">
        <property type="protein sequence ID" value="ARF80012"/>
        <property type="gene ID" value="B6264_14820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33675">
        <property type="protein sequence ID" value="OEV33675"/>
        <property type="gene ID" value="HS99_0038490"/>
    </dbReference>
    <dbReference type="OMA" id="RMSADFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="836" mass="93616" checksum="6C625EEE7A9F2A22" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ26</accession>
    <name>A0A1E7MZ26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0038330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557096.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000421.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4297"/>
    <dbReference type="EnsemblBacteria" id="ARF80348">
        <property type="protein sequence ID" value="ARF80348"/>
        <property type="gene ID" value="B6264_16800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33686">
        <property type="protein sequence ID" value="OEV33686"/>
        <property type="gene ID" value="HS99_0038330"/>
    </dbReference>
    <dbReference type="OMA" id="VRWGRVS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="20354" checksum="5D77AF8656078BA3" modified="2017-01-18" version="1">MGWTRGGRETKDAEFLELVSSRTGHLYRSACLLTSGDTHYAEDLVQEALSRMYVLWRRSAFTGGRNRIENPAAYTHTVMVRTFIAQQRRRSSGERPTETLPEREGHDADSSLRLTLLDALGRMSAKDRAVLVLRYWEDRSVEETAEVLRLSSGAVRTRTTRALARLRTLLGDSLAELAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ68</accession>
    <name>A0A1E7MZ68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551953.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000222.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1928"/>
    <dbReference type="EnsemblBacteria" id="ARF79613">
        <property type="protein sequence ID" value="ARF79613"/>
        <property type="gene ID" value="B6264_12460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33711">
        <property type="protein sequence ID" value="OEV33711"/>
        <property type="gene ID" value="HS99_0038195"/>
    </dbReference>
    <dbReference type="OMA" id="QWVNAGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="43951" checksum="9A03E95EB16D7ED3" modified="2017-01-18" version="1">MSGDQPSATPEPGRTHGTGEHHLWGPLLDRTQELPPQMIAPLVADAVRRFGGRDPVLLLQDYGQLVLAPLHGRGLTAGEPVPIDASPAGEAFLRGVPVEEPQEDGVRMYLPLPDGGDQVGVLALTLDAVDEDDRRLLRVFCALVADLLVTKNAFTDRIFQARRLQPMSVAAEIQWSLLPPLSMTVPLVAVAGILEPAYHVAGDSFDYALNDDLLHVATIDAMGHGLDAATMATVAIGAYRHARRADIGLAEIYAFMDRAIAEQFGPDHFVTAQMMRLDTVTGHLQWVNAGHPAPLLIRGRLVVERLESAPTLPVGFGGEQPVISERRLRHGDRVLCFTDGLVEERAPGGEQFGEHQLIDWVNRVERSDTGLRTMVRMLSHVLKEERGGRTSDDATLFAIEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG0</accession>
    <name>A0A1E7MZG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-aminobutyrate--2-oxoglutarate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290400.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000674.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4402"/>
    <dbReference type="EnsemblBacteria" id="ARF80320">
        <property type="protein sequence ID" value="ARF80320"/>
        <property type="gene ID" value="B6264_16655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33840">
        <property type="protein sequence ID" value="OEV33840"/>
        <property type="gene ID" value="HS99_0037515"/>
    </dbReference>
    <dbReference type="OMA" id="TSGQMSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003867">
        <property type="term" value="F:4-aminobutyrate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004632">
        <property type="entry name" value="4NH2But_aminotransferase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00700">
        <property type="entry name" value="GABAtrnsam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="451" mass="47082" checksum="6AA77FFBAE970085" modified="2017-01-18" version="1">MSAVTPLPQERRLVTAIPGPKSQELQARKLGAVAAGVGTTLPVYVTRANGGVLEDVDGNSLIDFGSGIAVTNVGNSAEAVVAKASEQLAAFTHTCFMVTPYEGYVAVAEQLNELTPGDHDKRTALFNSGAEAVENAVKIARAYTKRTAVVVFDHGYHGRTNLTMGLTAKNMPYKQGFGPFAPEIYRVPVAYPYRWLTGAENCAAEAAAQAIEIINKQIGADNVAAIIIEPIQGEGGFIEPAKGFMPAIVEFAKANGIVFVADEIQTGFCRTGQWFACEDEGIVPDLITTAKGIAGGLPLAAVTGRAEIMDAAHAGGLGGTYGGNPVACAAALGAIETMKEQDLVGKAQRIGEVMLGRLRAMQEKFDVIGDVRGRGAMIAVELVKPGSKEPNPELTAAVAKACHAEGLVVLTAGTYGNVLRFLPPLVIPEHLLTEGLDIIEGAFALQGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N040</accession>
    <name>A0A1E7N040_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent 2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fadH</name>
        <name evidence="2" type="ORF">HS99_0011500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551839.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2310"/>
    <dbReference type="EnsemblBacteria" id="ARF77915">
        <property type="protein sequence ID" value="ARF77915"/>
        <property type="gene ID" value="B6264_02350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34058">
        <property type="protein sequence ID" value="OEV34058"/>
        <property type="gene ID" value="HS99_0011500"/>
    </dbReference>
    <dbReference type="OMA" id="PRGAYTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="680" mass="73132" checksum="A20045083E16CB2E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H8</accession>
    <name>A0A1E7N0H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1964"/>
    <dbReference type="EnsemblBacteria" id="ARF79588">
        <property type="protein sequence ID" value="ARF79588"/>
        <property type="gene ID" value="B6264_12285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34200">
        <property type="protein sequence ID" value="OEV34200"/>
        <property type="gene ID" value="HS99_0037135"/>
    </dbReference>
    <dbReference type="OMA" id="NVYNATP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="22519" checksum="652AC0E1302B5670" modified="2017-01-18" version="1">MSMLTPQGLKGKQYRITGNAYPRLGRPPKKSRKVIAALAALLALALIGLGGVQLYDIFRGRTGNASAQACADPSGKPLAAPTPGATPGTPAASGAPAAALDPHAVPAPTAVTVNVYNATTKAGLAGRTADELKKRGFVIGKVGNAPAELDKKVPGTAQVIAGPTGAAAGTLVSSQIAGATVTADARTDASVDFVIGDSYNALLDETQAAAALALAIKPSPTPSATGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M5</accession>
    <name>A0A1E7N0M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285702.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6055"/>
    <dbReference type="EnsemblBacteria" id="ARF78148">
        <property type="protein sequence ID" value="ARF78148"/>
        <property type="gene ID" value="B6264_03765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34232">
        <property type="protein sequence ID" value="OEV34232"/>
        <property type="gene ID" value="HS99_0036865"/>
    </dbReference>
    <dbReference type="OMA" id="RTRETWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="19177" checksum="337ED46A019D9550" modified="2017-01-18" version="1">MSADTPRRIIVLRHAKADWPNGVDDHERPLADRGRHQAPDAGRWLADSGINPDFVLCSTALRTRETWKLAAHELPKRTRKTVYEDRIYEASPGEIIAVLHETPEEYADVVLVGHNPGVLGLTQVLAGDAGDRDALERLRLGGFPTAAIAVLSFSGSWKGVEPGVAELVSYHTPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N120</accession>
    <name>A0A1E7N120_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283318.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3930"/>
    <dbReference type="EnsemblBacteria" id="OEV34376">
        <property type="protein sequence ID" value="OEV34376"/>
        <property type="gene ID" value="HS99_0036260"/>
    </dbReference>
    <dbReference type="OMA" id="RLHHRKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="29376" checksum="8213D82342AE99B8" modified="2017-01-18" version="1">MTDMQVNPSFRLAYVPGVTPGKWARVWIERLPDVPLDLVAVPSTEGERTVREGEVDAGLVRLPVDKDVLSAIPLYTETTVVVFPKDHWLAAAEEVALGDLAEEVVFHPLDDTLGFTAETLPGRPAIARPDTTADAVELVAANVGVLLVPQSLARLHHRRDLTYRPVAEGPQSQVALSWPQERTTDLVEEFIGIVRGRTVNSSRGRGAGQAAEAPSKEQPGKAAAPRKPQQQKAGGQKAAGQKTGGQKAGGQKPGPQKGRGGGPAAAARRGKPKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N188</accession>
    <name>A0A1E7N188_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1072"/>
    <dbReference type="EnsemblBacteria" id="ARF78959">
        <property type="protein sequence ID" value="ARF78959"/>
        <property type="gene ID" value="B6264_08535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34444">
        <property type="protein sequence ID" value="OEV34444"/>
        <property type="gene ID" value="HS99_0035660"/>
    </dbReference>
    <dbReference type="OMA" id="MIRSKRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="8974" checksum="560ADC8EB3F2E1C1" modified="2017-01-18" version="1">MVRLKQLGRRVGTAGALGAAGMLLSSGAVAHADPVAEPDPGVTPEPAAAQFGPVLGDSVGPDAGLLAVGGGLVVAAGGAALWLKRRRAGEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B4</accession>
    <name>A0A1E7N1B4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0035415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279065.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7063"/>
    <dbReference type="EnsemblBacteria" id="OEV34490">
        <property type="protein sequence ID" value="OEV34490"/>
        <property type="gene ID" value="HS99_0035415"/>
    </dbReference>
    <dbReference type="OMA" id="VHFFGYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="11">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="132"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="13">
        <location>
            <begin position="529"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="752" mass="81302" checksum="6BEAB875A73A94FE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q4</accession>
    <name>A0A1E7N1Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554762.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000116.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4281"/>
    <dbReference type="EnsemblBacteria" id="ARF82021">
        <property type="protein sequence ID" value="ARF82021"/>
        <property type="gene ID" value="B6264_26850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34614">
        <property type="protein sequence ID" value="OEV34614"/>
        <property type="gene ID" value="HS99_0008940"/>
    </dbReference>
    <dbReference type="OMA" id="EADEWIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="18352" checksum="78F09A27F5A6A2D8" modified="2017-01-18" version="1">MPLDDQHIWALLKNLDDPDHMEFPQSYDHATTRARFDQLADRLAQRFRCTCTVDRGVQDANHHGTVVIPTSATASGDHITITVSNYGNLVAVTLGNPGSYDKEEENVLFETADRRPIDDELDALGYTAVSEHLLWTRYDGVSNLGTCFEPRTWWDRFFDYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N268</accession>
    <name>A0A1E7N268_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388968.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81839">
        <property type="protein sequence ID" value="ARF81839"/>
        <property type="gene ID" value="B6264_25730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34800">
        <property type="protein sequence ID" value="OEV34800"/>
        <property type="gene ID" value="HS99_0010010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13915" checksum="69E799FA0DD09412" modified="2017-01-18" version="1">MLVAHSMGGLVARRAVERLGPRLRGLPACRTVPLSASRPVRDREQHHAALVEHQRRWAEALPDSWFETVDSGHFIQAEQPGIVADQVRHLLDRAPRPERPTGLTPPCHPHLPPGGIPEADRPLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G0</accession>
    <name>A0A1E7N2G0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0008905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389750.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000125_gene168"/>
    <dbReference type="EnsemblBacteria" id="OEV34872">
        <property type="protein sequence ID" value="OEV34872"/>
        <property type="gene ID" value="HS99_0008905"/>
    </dbReference>
    <dbReference type="OMA" id="YTHAWIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198685" description="Amino_oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="621" mass="67256" checksum="9B506740B1AABE14" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G6</accession>
    <name>A0A1E7N2G6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4627"/>
    <dbReference type="EnsemblBacteria" id="OEV34881">
        <property type="protein sequence ID" value="OEV34881"/>
        <property type="gene ID" value="HS99_0009610"/>
    </dbReference>
    <dbReference type="OMA" id="KWVIFAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026266">
        <property type="entry name" value="AraF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002816">
        <property type="entry name" value="AraF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198680" evidence="1">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="41"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="34239" checksum="7AB43E2C610EEEC6" modified="2017-01-18" version="1">MGAAVVLGLTACSTGQTSSSGAGPASVAPVTGKVSLTYLQKQGDQQYFIDEANGAKAKAAELGVDLKVVNLGSDANKTVSEVQSAIAQKTNGLIVVVPDPAVGPQVVQTARDAKVALLTSDDQVCTNSPTPANCDKANLVPRIGFSGQQMGTEVGKRAAEDFKKAGWNAADTRVISASKQDVTVCGDRVKAAKEAFNIGAGASVQTIDVATDNTPTGAQDKVAATITANPGVKHWVVWGCNDENVQGGVTALQNAGVGPDNIIGVGLGAYLACKDWGPGAPSGMKASLFINGSDIGALAVQTMYDNLKNGKPMPAEAFAPTTMVDASTWQSAGVKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G9</accession>
    <name>A0A1E7N2G9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557022.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3250"/>
    <dbReference type="EnsemblBacteria" id="OEV34888">
        <property type="protein sequence ID" value="OEV34888"/>
        <property type="gene ID" value="HS99_0009920"/>
    </dbReference>
    <dbReference type="OMA" id="WTRRPAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="827"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="892" mass="93253" checksum="F0811327FEDAEEAB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P5</accession>
    <name>A0A1E7N2P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7661"/>
    <dbReference type="EnsemblBacteria" id="OEV34969">
        <property type="protein sequence ID" value="OEV34969"/>
        <property type="gene ID" value="HS99_0034725"/>
    </dbReference>
    <dbReference type="OMA" id="WPSQLDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="39900" checksum="E57E6E43AB307440" modified="2017-01-18" version="1">MAPQESERLARVLLNRLSEPGDAVVGRWLRELPAVEVVRAIRDGDVPDHPGLDSARLAAYQARLPGLAPADDLKRVRDAGGRFIIPGDTEWPSQLDDLGDGRPIGLWTTGTGSLRLLALRSVALVGSRACTAYGAHVAGELSAQLAERGWVVVSGAAYGIDAAAHRGALAVGGMTVAVLACGVDVAYPKGNAELIRRIGVQGLLVSELPPGEHPNRFRFVLRNRVIAALTRGTVVVEAALRSGALSTARRARDLNRHTMGVAGPVTSELSAGVHALIRSGGATLVTDATEITDLVGAIGDDLAPQRSGPVLPRDLLEPAVARVLEAVPATAEGAPVERLARQSGLPPDEVLQRLYELVSLGFVERHGAHWRVVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P6</accession>
    <name>A0A1E7N2P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein often found in actinomycetes clustered with signal peptidase and/or RNaseHII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030056781.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7664"/>
    <dbReference type="EnsemblBacteria" id="OEV34968">
        <property type="protein sequence ID" value="OEV34968"/>
        <property type="gene ID" value="HS99_0034710"/>
    </dbReference>
    <dbReference type="OMA" id="YETDMEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="12952" checksum="D9283FFF7CA3F529" modified="2017-01-18" version="1">MSAEDLEKYETEMELKLYREYRDVVGLFKYVIETERRFYLTNDYELQVHSVQGEVFFEVSMADAWVWDMYRPARFVRKVRVLTFKDVNIEELAKSDLELPSDESGFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q1</accession>
    <name>A0A1E7N2Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000815.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5871"/>
    <dbReference type="EnsemblBacteria" id="ARF77543">
        <property type="protein sequence ID" value="ARF77543"/>
        <property type="gene ID" value="B6264_00125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34945">
        <property type="protein sequence ID" value="OEV34945"/>
        <property type="gene ID" value="HS99_0034970"/>
    </dbReference>
    <dbReference type="OMA" id="ARYVHYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="41075" checksum="116551E6877A2494" modified="2017-01-18" version="1">MSTQSGVSLEIEPTVDVDRSDPNYRAWLKEAVRKVQADANRSADTHLLRFPLPAEWGIDLYLKDESTHPTGSLKHRLARSLFLYGLCNGWIRPGKPVIEASSGSTAVSEAYFAQLIGVPFIAVMAKSTSQAKIDLIQFHGGECHLVERSDEVYEASAKLAEETGGHYMDQFTYAERATDWRGNNNIAESVFAQLRLEPHPEPTWIVATAGTGGTSATIARYVHYMQYDTRICVADPENSCFFDGWVNHDPDAACGSGSRIEGIGRPRMEPSFVPGAVDRMMKVPDAASIAAVRVLEQVLGKKAGASTGTGLWSALRIVAEMRTAGRTGSVVTLICDPGDRYLDKYYSDAWLAGERIDIAPYRAAMESFLTGGAWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N349</accession>
    <name>A0A1E7N349_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554297.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35107">
        <property type="protein sequence ID" value="OEV35107"/>
        <property type="gene ID" value="HS99_0034170"/>
    </dbReference>
    <dbReference type="OMA" id="APYERPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="19356" checksum="9E0CC9BF218A2423" modified="2017-01-18" version="1">MADSDDRQASTQVWGAAVVVGSALAVVAAYLINGAPLVLVVAGIETVLVMVYVGRRWRALHREAVPAGHRLRRGIPDAAHCDRCRRAREALDARQEHGAAGSAGSAVRAVRAVRPEAAPELTELPSAPESGTADHPSSPRRPQGRAPYERPWTAERAATRSVDRSTARRSAPGSAGRAVRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3C7</accession>
    <name>A0A1E7N3C7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name evidence="2" type="ORF">HS99_0034670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7672"/>
    <dbReference type="EnsemblBacteria" id="ARF78537">
        <property type="protein sequence ID" value="ARF78537"/>
        <property type="gene ID" value="B6264_06090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34963">
        <property type="protein sequence ID" value="OEV34963"/>
        <property type="gene ID" value="HS99_0034670"/>
    </dbReference>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20050" checksum="28B060488472FC6C" modified="2017-01-18" version="1">MQLVVGRIGRAHGIRGDVSVEVRTDEPELRLGPGAVLLTDPASAGPLTVESGRVHSGRLLLRFAGVKDRNAAEALRGTLLISEVDPEERPEDPEEYYDHQLIGLDVVLLDGTPVGELTEVVHLPYQDLLTVRKADGTEVLVPFVTQIVPTIDLENQRAVITPPAGLIDPDQAEVVGTASEEPEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E0</accession>
    <name>A0A1E7N3E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4454"/>
    <dbReference type="EnsemblBacteria" id="OEV35185">
        <property type="protein sequence ID" value="OEV35185"/>
        <property type="gene ID" value="HS99_0033765"/>
    </dbReference>
    <dbReference type="OMA" id="DDPWYDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14087" checksum="DEBA7E2B41A58921" modified="2017-01-18" version="1">MPTVAPAAVAPAAVAQEPTAQADTPDSTQVYRSVQASPAFQDIRRSYRTFVFPACGAFLGWYLLYVAAEAVAPGAMRSPVAGPLNVAWLLGLLQFASTFLLTWLYARNARTKRDRAALGLRWDTQDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I3</accession>
    <name>A0A1E7N3I3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552855.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4688"/>
    <dbReference type="EnsemblBacteria" id="OEV35013">
        <property type="protein sequence ID" value="OEV35013"/>
        <property type="gene ID" value="HS99_0034315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7226" checksum="4DF8194A742E46CB" modified="2017-01-18" version="1">MITNGALEPVASCGPHTAPRPPLSRVPGAIPFSPAAGTSAAAPPPGSRPAGTVQVTLCPAMPGPRFAGDNGWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3S2</accession>
    <name>A0A1E7N3S2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278749.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000709.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2448"/>
    <dbReference type="EnsemblBacteria" id="ARF81540">
        <property type="protein sequence ID" value="ARF81540"/>
        <property type="gene ID" value="B6264_23860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35336">
        <property type="protein sequence ID" value="OEV35336"/>
        <property type="gene ID" value="HS99_0032455"/>
    </dbReference>
    <dbReference type="OMA" id="YTYVPNK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="26227" checksum="13AEE759A0F3AD7D" modified="2017-01-18" version="1">MTVYAGQGDPDRSLALLWGGEEPRTGRSGPKPGLSVDAIVSAGIAVADAEGMSALSMRAVGERLGRTAMALYTYVPGKAELLDLMHDRVLAELPGGLPLSDGWRAAVTAWAEDLYACYLRHPWVLQVSQARPVLGPAELTAMERLLAALQPAALAPERLRGAVAALWQFVRGTAATTADARGAAAATGVADEDWWNARSARLAELAPDFPQRFPLLTALQSAGGGAPEDSGREAFRTGLAVLLDGVASGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N561</accession>
    <name>A0A1E7N561_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3366"/>
    <dbReference type="EnsemblBacteria" id="ARF81042">
        <property type="protein sequence ID" value="ARF81042"/>
        <property type="gene ID" value="B6264_20950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35832">
        <property type="protein sequence ID" value="OEV35832"/>
        <property type="gene ID" value="HS99_0008170"/>
    </dbReference>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="34876" checksum="E9939F705C5E773D" modified="2017-01-18" version="1">MEKRHLGRTGLQVSRLGLGTMTWGRDTDEHEAAEQLKEFVDAGGNLVDTADVYADGGAEYLISRLTDSLIPRSEVVIATKAGSVPESARRFDGSRGHLLAALDASLRRLGTDYVDLWQVHAFDPMTPVEETLSALDIAVSSGRARYAAVCDFSGWQLAKAATWQRAHHARMPLAGAQWEYSLLQRGIEREALPAALDAGVGILAGSPLGRGVLTGKYRHGVPQDSRGASAYLSGFVQPYLGERSRRIVDAVATAADGLASSPLAVALAWVRDRPGVACALVGARTVAQLQAALSVEALTLPDEIRGALDDISSPVHRYPDQGWTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N563</accession>
    <name>A0A1E7N563_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3374"/>
    <dbReference type="EnsemblBacteria" id="OEV35825">
        <property type="protein sequence ID" value="OEV35825"/>
        <property type="gene ID" value="HS99_0008130"/>
    </dbReference>
    <dbReference type="OMA" id="DWSALAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="29837" checksum="B9BAFBF93DB0ED83" modified="2017-01-18" version="1">MIDGMHRLRVAAAEGRPDIPVRFFEGLERDAFVLSVQSNTRHGLPLSRAERTAAASRILGSHADWADRMIAEVTGLSTKTVRALRREMDGAIPHSATRIGRDGRARPLDSATGRLRASELIAANPRASLRAIADEAGISPGTVRDVRERLRRGEDPVPAGRRAPASQQAGPDLARTMERLMSDPALRLTESGRHLLRMLTSSLPPAEQRDQLVRSVPPHCAGRVSQLALECAAAWQEFARLVETARPDLAPEGWSSAAGAVASSTRSHGAGRADAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N579</accession>
    <name>A0A1E7N579_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Proteasome core protein PrcB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prcB</name>
        <name evidence="4" type="ORF">HS99_0008280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="3">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3343"/>
    <dbReference type="EnsemblBacteria" id="ARF81062">
        <property type="protein sequence ID" value="ARF81062"/>
        <property type="gene ID" value="B6264_21060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35850">
        <property type="protein sequence ID" value="OEV35850"/>
        <property type="gene ID" value="HS99_0008280"/>
    </dbReference>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_B">
        <property type="entry name" value="Proteasome_B_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022483">
        <property type="entry name" value="PSB_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03690">
        <property type="entry name" value="20S_bact_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5033204783" description="Removed in mature form; by autocatalysis" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033204784" description="Proteasome subunit beta" evidence="3">
        <location>
            <begin position="53"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="29785" checksum="3FEB490FDE387506" modified="2017-01-18" version="1">MEANTRGTGRLPAAFLTPGSSSFLDFLAEHKPELLPGRTGLPEGSVVEAPHGTTIVAAVFDGGVVIAGDRRATMGNVIAQRDIEKVFPADEYSAVGIAGTAGLAVEMVRLFQLELEHYEKIEGTTLSLEGKANRLTSMIRGNLGMAMQGLAVVPVFAGYDLDRGRGRIFNYDVTGGRSEERGFAATGSGSVFARGSLKKLYREDLTAEQAVTLVVQALYDAADDDSATGGPDLARKIFPIVSLITEDGFRRLTDAEVAETVVAITDERLTRPDGPRAPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D8</accession>
    <name>A0A1E7N5D8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286229.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7279"/>
    <dbReference type="EnsemblBacteria" id="ARF81110">
        <property type="protein sequence ID" value="ARF81110"/>
        <property type="gene ID" value="B6264_21330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35899">
        <property type="protein sequence ID" value="OEV35899"/>
        <property type="gene ID" value="HS99_0008555"/>
    </dbReference>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="30076" checksum="C4C0BF2A136CD6AE" modified="2017-01-18" version="1">MPSTETPLLTSLRSPRVVAARRLAKRNQRTKERRFLAEGPQAVREAIAFGKLPGTAEHAVVEVYVGLEAAERHADIVEAALAEGLPVLTATDEVIADICDTVTPQGIVALCRFIDTPFAEVLAARPKLVAILAHVRDPGNAGTVLRTADAAGADAVVLTDASVDLYNPKAVRASVGSLFHLPVAVGVPVEEAVGQLRAAGVRVLAADGAGERDLDQELDEGTLGAPGAWVFGNEAWGLPEETRALTDEVVRVPIHGHAESLNLATAAAVCLYASARAQRSPGGCRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5H9</accession>
    <name>A0A1E7N5H9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FhuF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene859"/>
    <dbReference type="EnsemblBacteria" id="OEV35957">
        <property type="protein sequence ID" value="OEV35957"/>
        <property type="gene ID" value="HS99_0007340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="27959" checksum="8B2DA95747908EEE" modified="2017-01-18" version="1">MTALTPILDVRCAPPRRGGGWLPVADLTADPGAVRELVAHNARQGLARYGRPLRPDVAAGFGLHRLVWPVSLLFTVPWFLERRVPLLGPDDVSLRRGPASAELTVRPEAFVCLPDDPAAGSPGARTAPDENALAARLRCSLGEFLAPVLTAFRPEVRRGPRVLWAMATDAVVEGLWYAGGLLGERERARAELSALLVPGERSACAPGAGPTPAPAPAPFTPGAGFAPPAPGRTGASGTDRSRASCCLVYTVEPGEMCGGCPRVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M2</accession>
    <name>A0A1E7N5M2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene796"/>
    <dbReference type="EnsemblBacteria" id="ARF80960">
        <property type="protein sequence ID" value="ARF80960"/>
        <property type="gene ID" value="B6264_20435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35753">
        <property type="protein sequence ID" value="OEV35753"/>
        <property type="gene ID" value="HS99_0007660"/>
    </dbReference>
    <dbReference type="OMA" id="HTVLYLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="25067" checksum="12D3BC93A67022E4" modified="2017-01-18" version="1">MSTASASNVFAGQRTVVMGGSSGIGEATATAFAADGAEVVITGRDREKLDVAVARIGGSTSGVQLDATDPAALAAFFTATGTVDHLVVAVSGAAGSGAFADLDLADLAHGFDAKFWPQVRVLQAALPHLRKDGSVTLITAASARAAIPGTAGLAAINGALEAMVPPLAVELAPLRVNAVSPGVIDTPWWDRVPSEQRTALFDGLAATTPVGRVGRPEDVARAIHMFAANTFVTGVVLDCTGGANLPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P5</accession>
    <name>A0A1E7N5P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287437.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000409.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene485"/>
    <dbReference type="EnsemblBacteria" id="ARF78833">
        <property type="protein sequence ID" value="ARF78833"/>
        <property type="gene ID" value="B6264_07800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36005">
        <property type="protein sequence ID" value="OEV36005"/>
        <property type="gene ID" value="HS99_0031335"/>
    </dbReference>
    <dbReference type="OMA" id="PARRDWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="428" mass="47119" checksum="C9F75E4BE9E27F58" modified="2017-01-18" version="1">MAGPGTRVFISHLSAIAVFDPNGDQVGRVRDVVVSLRLGGRPPLVLGLVVEVVARRRIFLPMTRVTSLESGQVLTTGLINLRRFEQRPAETLVLAELLDRTVTWTKTGEDVTVLDVGMVQTRLREWEVSKVFVQVGRASRLRKGKGERLTLDWQDVTGFSLPEQDQGAANLLATFEQLRPADLASVMHHLSAKRRAEVAAALPDERLADVLEELPEDDQVEIIGKLQEERAADVLEAMDPDDAADLLSELPGDEAERLLGLMEPEEAAPVRRLLSYEEDTAGGLMTTEPIVLEPDATVAEALARIRIRDHKPALAAQVYVCRPPNETPTGKYLGTVHFQRLLREPPYVLVGELVDDDLDALPPDTPLSLVTSYLATYNLVAAPVVDEADHLLGAVTVDDVLDHLLPEDWRDADLHAGDDDREEMHGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R2</accession>
    <name>A0A1E7N5R2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287470.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000230.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene502"/>
    <dbReference type="EnsemblBacteria" id="ARF78818">
        <property type="protein sequence ID" value="ARF78818"/>
        <property type="gene ID" value="B6264_07720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36019">
        <property type="protein sequence ID" value="OEV36019"/>
        <property type="gene ID" value="HS99_0031410"/>
    </dbReference>
    <dbReference type="OMA" id="ATVCEAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="35640" checksum="5E0D6411299F791E" modified="2017-01-18" version="1">MRVLLLGADGFIGRRVTDRLLMDQELQVTVLGRRDSADIRFDLTTGSPGALARFLDAVAPQVVINCAGATYGSSRTLIRSNTLAVATVCEAIRRSREPARLVHVGSAAEYGPVPGGVPVSEQAEPRPVGPYGVSKLAGTELVLASGLDAAVLRVFDVVGPGAPTASLFGRLAEGLRRALERDENQVRMPDLSGYRDFVDVRDVARAIQAAAVSAATGVINVGSGHAVRARDAAQLLVRASGFEGAIVEENRQVLLPAQVGGQGGDHLAGHGHQSGQYLPGHRPEERRPEGRPAPGEPVPWRQADVRTARDRLGWRTQVPLEESLGDVWLETACRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N669</accession>
    <name>A0A1E7N669_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551624.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8108"/>
    <dbReference type="EnsemblBacteria" id="ARF79786">
        <property type="protein sequence ID" value="ARF79786"/>
        <property type="gene ID" value="B6264_13505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36175">
        <property type="protein sequence ID" value="OEV36175"/>
        <property type="gene ID" value="HS99_0030460"/>
    </dbReference>
    <dbReference type="OMA" id="CDVTAHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="36632" checksum="1F839EB3F1B6667A" modified="2017-01-18" version="1">MTWMRWAPAMERALYDPDGGFYRRPEGPAGHFRTSVHASPRFARAVARLLLEVDEALGRPEELALVDIGAGRGELLTGVLAELPREVLARLRPYGVELARRPDGLPSTALWTAEPPRGVTGLLFANEWLDNVPLDVGEVDGDGVLRYREVDTATGEERLGEPVSAADAAWAERWWPVAEPGEVVEFGGPRDAAWARAVAGLERGLAVAVDYGHTAGRRPPCGTFTGFRDGREVPPVPDGSCDVTAHVALDAIAVPGLHSLWTTQREALRALGVSGGRPPLTLASTDPAAYLRALGGAGEGAELTDPAGLGGFGWVLQAVRMPPLDVFERAQSLGALPGWHTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F6</accession>
    <name>A0A1E7N6F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283526.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000157.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2664"/>
    <dbReference type="EnsemblBacteria" id="OEV36259">
        <property type="protein sequence ID" value="OEV36259"/>
        <property type="gene ID" value="HS99_0030070"/>
    </dbReference>
    <dbReference type="OMA" id="FRLFWRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="564" mass="62209" checksum="7A604850C5DF66F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N9</accession>
    <name>A0A1E7N6N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7179"/>
    <dbReference type="EnsemblBacteria" id="ARF82346">
        <property type="protein sequence ID" value="ARF82346"/>
        <property type="gene ID" value="B6264_28820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36361">
        <property type="protein sequence ID" value="OEV36361"/>
        <property type="gene ID" value="HS99_0029835"/>
    </dbReference>
    <dbReference type="OMA" id="VMTSICL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16185" checksum="D621FA2802A8981E" modified="2017-01-18" version="1">MSEVTEMDGPALSGWERRLLEEIESDLRQDTRLDRKLSTMGAKPPNRVLRALHAAGRRISAGVLLTVLVMTSICLGIGMRTPTTAVLVALGVVWAASVAASVAATELLRRRRGAGRAEPAGPAREERRERRPWDRPERRPWDRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W7</accession>
    <name>A0A1E7N6W7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280638.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7791"/>
    <dbReference type="EnsemblBacteria" id="ARF82278">
        <property type="protein sequence ID" value="ARF82278"/>
        <property type="gene ID" value="B6264_28435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36419">
        <property type="protein sequence ID" value="OEV36419"/>
        <property type="gene ID" value="HS99_0029180"/>
    </dbReference>
    <dbReference type="OMA" id="MNLRRDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="104" mass="12000" checksum="962E08A3A748EB33" modified="2017-01-18" version="1">MADVDVFSALANPVRRKLLESLRAGPRAAGELAGEFELSRPAVSEHLAVLRNARLVREEPRGRHRYYHLEPGPLAAVEEWLQPFERYWRARMRSLHRLLDEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W9</accession>
    <name>A0A1E7N6W9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289731.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene214"/>
    <dbReference type="EnsemblBacteria" id="ARF82249">
        <property type="protein sequence ID" value="ARF82249"/>
        <property type="gene ID" value="B6264_28245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36446">
        <property type="protein sequence ID" value="OEV36446"/>
        <property type="gene ID" value="HS99_0029360"/>
    </dbReference>
    <dbReference type="OMA" id="GVNMHTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12429" checksum="9A23B129272DCB28" modified="2017-01-18" version="1">MLLKLDLGDARPLHEQVAGAIRRAVAEGECAPGDKLPPARELSRALGVNTNTVLRGLRALRDEGVLEFRRGRGITVATDAGTRAELVDRVRQLIADAARSGYSRNDLVDLIRGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y1</accession>
    <name>A0A1E7N6Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene208"/>
    <dbReference type="EnsemblBacteria" id="ARF82245">
        <property type="protein sequence ID" value="ARF82245"/>
        <property type="gene ID" value="B6264_28215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36450">
        <property type="protein sequence ID" value="OEV36450"/>
        <property type="gene ID" value="HS99_0029390"/>
    </dbReference>
    <dbReference type="OMA" id="ALQMVIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="23683" checksum="FD4AEE9F1BE82A2E" modified="2017-01-18" version="1">MIRVVLADDQPLVRAALEMVITETADVEVVGEAGDGAEAVRLAAELRPDVVVMDIRMPGTDGIEATRQVTAAGGPTRVVVLTTFDEDEHVYAALRAGASGFLVKDMALDDILAAVRVVAAGDALIAPSVTRRLIGAFAGQHPKLNPNPAAVPASRRLDAITDREREILTLVGRGLSNTEIAAELVLSIATVKTYMTRLLAKLDARDRVQLVILAYETGLVSVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D5</accession>
    <name>A0A1E7N7D5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000290.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1441"/>
    <dbReference type="EnsemblBacteria" id="ARF82730">
        <property type="protein sequence ID" value="ARF82730"/>
        <property type="gene ID" value="B6264_09735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36601">
        <property type="protein sequence ID" value="OEV36601"/>
        <property type="gene ID" value="HS99_0028845"/>
    </dbReference>
    <dbReference type="OMA" id="GHYKSVA"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="13150" checksum="32E5A8EE23914909" modified="2017-01-18" version="1">MDRVTLRGLRARGHHGVFERERVEGQTFVVDLVLYLDTRPAASGDDLTRTAHYGIVAEEVTAIIAGEPVDLIETLAQRIADQCLKHDAVEEVEVTVHKPDAPITVPFDDVTVTIHRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K9</accession>
    <name>A0A1E7N7K9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278827.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2486"/>
    <dbReference type="EnsemblBacteria" id="ARF81514">
        <property type="protein sequence ID" value="ARF81514"/>
        <property type="gene ID" value="B6264_23680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36686">
        <property type="protein sequence ID" value="OEV36686"/>
        <property type="gene ID" value="HS99_0028395"/>
    </dbReference>
    <dbReference type="OMA" id="QGGIIKH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="56895" checksum="0378AD9257F98096" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X3</accession>
    <name>A0A1E7N7X3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737865.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4830"/>
    <dbReference type="EnsemblBacteria" id="OEV36791">
        <property type="protein sequence ID" value="OEV36791"/>
        <property type="gene ID" value="HS99_0027695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15614" checksum="75FD1B2C44422B5A" modified="2017-01-18" version="1">MAGAAEPGELALDLELAEKAAFRTLGCMLYGMGRTADAVFWWRIGAQYGDQLAVHCLAVHYAAEGELRDAARWAAEAEDLSAPGRLPELAPQARPGCAAELARLLAERYDGEILLTLREAVAARTGAADAGPLGVRAVRGRGVTRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N808</accession>
    <name>A0A1E7N808_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366344.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000472.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4868"/>
    <dbReference type="EnsemblBacteria" id="ARF82395">
        <property type="protein sequence ID" value="ARF82395"/>
        <property type="gene ID" value="B6264_29125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36821">
        <property type="protein sequence ID" value="OEV36821"/>
        <property type="gene ID" value="HS99_0027885"/>
    </dbReference>
    <dbReference type="OMA" id="AHDEATH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="27176" checksum="A8AD3F61924D3F66" modified="2017-01-18" version="1">MTTGREVEPDSGTRTAGGERTVFRVPRRERAHAERIAVLRQARLTAAPAHLPSEHEQASFELGLVIALVLGAPCASRGLDLLVNARRIQPEGAEVFGALLYATGKEEGAEFWWRFAAGSGSGTAAYCLHLHHLKLGETDDADYWRAWSEQLSSAERPPGPRPLRMSRPLLPENVRRDILSRVHRGLAPQLPPALVSVIDRLPLQGGDTEVAQEVPSPWGLTSGTTAACSWDLPWEFGETGRGREEDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N872</accession>
    <name>A0A1E7N872_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6482"/>
    <dbReference type="EnsemblBacteria" id="OEV36895">
        <property type="protein sequence ID" value="OEV36895"/>
        <property type="gene ID" value="HS99_0026900"/>
    </dbReference>
    <dbReference type="OMA" id="GRFRDIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="22290" checksum="3D1AEC1022DAA8A7" modified="2017-01-18" version="1">MSSATVETRPRQQNPVGWLWRRFREFRRTRPFWGGLLAMIAGAPILYFPYAHLSLGGLTIAMSTTAGAGSLIIGVLMIILGLTAWFQPAVRFFAGVATILLTLVSIPVSNLAGFGLALLPGLIGGGLMVSWAPLPEPATEPAKGRRARRAKQVDNPIAQRVAAEPAATEPAKAEAVEAPTAKLPAQGAPKEPAAEPAVPQQPTAGEQEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M4</accession>
    <name>A0A1E7N8M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556186.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81696">
        <property type="protein sequence ID" value="ARF81696"/>
        <property type="gene ID" value="B6264_24840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37029">
        <property type="protein sequence ID" value="OEV37029"/>
        <property type="gene ID" value="HS99_0004160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8900" checksum="8EF7100E303391CE" modified="2017-01-18" version="1">MTNKKLGGAIYIDDRGMCFEGDGDTALPEALRRIGELPEPMAQLAAEVPALTIRQPWLAASLGGTSPGADVLGVSAAQWLGARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9D6</accession>
    <name>A0A1E7N9D6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555095.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37301">
        <property type="protein sequence ID" value="OEV37301"/>
        <property type="gene ID" value="HS99_0005785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15461" checksum="C20112EDFBF685ED" modified="2017-01-18" version="1">MAGAYGGGGDGRAGGTAGFQPRALASCRKCRALAEGAPSRPCGQERLHDLLLQEADDGPLRTDLLAALRRGARIAIWITGPAKDLTRFHSRIDRMTEEAGPAAEALAAAKNSITLARVEDTDRQYLVVLPPDGRARFARGAVAGSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G2</accession>
    <name>A0A1E7N9G2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37332">
        <property type="protein sequence ID" value="OEV37332"/>
        <property type="gene ID" value="HS99_0005975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="11619" checksum="B791DF6AF06EBC43" modified="2017-01-18" version="1">MLERERLSPGIIAVALSVWSVRVHGTRRRWRQWEAEFTCLCCGEGWARDKLQDALFMLPPRAASELRVQVERLDAALLERTHHEPMEDPELAWWHRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9S8</accession>
    <name>A0A1E7N9S8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small membrane hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555275.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000503.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37446">
        <property type="protein sequence ID" value="OEV37446"/>
        <property type="gene ID" value="HS99_0005560"/>
    </dbReference>
    <dbReference type="OMA" id="IMRETRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14566" checksum="40B0F0B12844E985" modified="2017-01-18" version="1">MSLKKINTVLVAAFILFILWFGGEFILSPGTTAPSFGLPSWPSGDGGGFLIIKGIRDVVLALVLGILLVTGHRRALGWALLVEALAAYGDMTTVLAHHGSVATALGVHGLTGTLMVVNGLLIMRETRTIAAASAPPAPQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9T1</accession>
    <name>A0A1E7N9T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37451">
        <property type="protein sequence ID" value="OEV37451"/>
        <property type="gene ID" value="HS99_0005760"/>
    </dbReference>
    <dbReference type="OMA" id="CIIKVAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16250" checksum="598B913748D5949F" modified="2017-01-18" version="1">MVLAHFIVSDDVERSRRFYTEVLGGRVAYSGPGGLTYVALANSWIIINVGGGPTDDKPTVTLDTPRDPDRVSSFLNIRVKDVHALYAEWSARGARFLTPPKQHEYEIRCYIRDPDGHLIEVGQTTDPEGDWSPAHWPPSTRAGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V1</accession>
    <name>A0A1E7N9V1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0004550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37424">
        <property type="protein sequence ID" value="OEV37424"/>
        <property type="gene ID" value="HS99_0004550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17347" checksum="D960EA7B157DBDFB" modified="2017-01-18" version="1">MIVHRELIDQARVDGYDAFCVGALIVRHGRLLMLRRAASDSWAGRWEPPGGGVETGESLAEALAREVQEEAGLAIASALYIGHLDYPAHENPLLPASRGFFFAAEEPPSRGPVRINQTEHDRFAWSRPDGVRSTRPDLRALVARRLALTSRSAPEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9X2</accession>
    <name>A0A1E7N9X2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37444">
        <property type="protein sequence ID" value="OEV37444"/>
        <property type="gene ID" value="HS99_0005465"/>
    </dbReference>
    <dbReference type="OMA" id="SFYAGPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="17612" checksum="ECD1FB52416C737A" modified="2017-01-18" version="1">MTAAGPSPESVWDYPRPPVIRTARGRLVQVWFGGTLIASTTQAVRVLETSHPPVYYLPASDVAGRFLVPSDGTSFCEWKGQARYWDLLVQGSRAVQAAWSYPRPLPAYRELSGRLAFYPARVDRCTVDGETVRAQDGDFYGGWITGEIAGPFKGGPGTSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y8</accession>
    <name>A0A1E7N9Y8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7982"/>
    <dbReference type="EnsemblBacteria" id="ARF79063">
        <property type="protein sequence ID" value="ARF79063"/>
        <property type="gene ID" value="B6264_09160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37510">
        <property type="protein sequence ID" value="OEV37510"/>
        <property type="gene ID" value="HS99_0026195"/>
    </dbReference>
    <dbReference type="OMA" id="HWASAEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="34925" checksum="76E0F6AABBE1246C" modified="2017-01-18" version="1">MAHLVAVLALEGAIAFELGIPARIFGNAKDDAGRPLYQVATCTLDGGPVATSADFRIAVDHGPELLERADTVVLPASHDSDPDLADAPFTPELAAALRRIRPGTRLMSICTGSFLLAAAGLLDGRPATTHWRYTELFARTFPKVLLDPDVLYTDDGDILTSGGVAAGVDLCLHVVRRDHGSAVANAVARNCLVPPWRDGGQKQYVEAPSPVTSGGTGTGTAAVRAWALEHLEEPLPLRRLADRAGMSVRTFTRRFREETGASPGQWITTQRTERARQLLERTDLTIDQVARRSGFGTGTSLRLQLRGRLDVAPSAYRRTFRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA11</accession>
    <name>A0A1E7NA11_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287200.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000481.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7997"/>
    <dbReference type="EnsemblBacteria" id="ARF79050">
        <property type="protein sequence ID" value="ARF79050"/>
        <property type="gene ID" value="B6264_09085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37522">
        <property type="protein sequence ID" value="OEV37522"/>
        <property type="gene ID" value="HS99_0026270"/>
    </dbReference>
    <dbReference type="OMA" id="KGVTHTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="13373" checksum="2B43685054BD12C1" modified="2017-01-18" version="1">MDSRIWESVDHLVAWLDEHSTQSPQEERLLRLLKLSEEVGEVGAAVIGATGQNPRKGVTHTWEDVQHELCDVVFSALVALRTLTPDAARVFAERLAYVEQRSAASRRPVDGPEETAAAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA16</accession>
    <name>A0A1E7NA16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366632.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000726.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7951"/>
    <dbReference type="EnsemblBacteria" id="ARF79089">
        <property type="protein sequence ID" value="ARF79089"/>
        <property type="gene ID" value="B6264_09310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37484">
        <property type="protein sequence ID" value="OEV37484"/>
        <property type="gene ID" value="HS99_0026045"/>
    </dbReference>
    <dbReference type="OMA" id="ICHVADR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="37965" checksum="8F3351646856D712" modified="2017-01-18" version="1">MTGTGEAVAAGVPGARGSGGDGLPRHVLDRATFRAIAGARGGPEAVRLLRAGQLSKRALLLVAMRRVAPRDEGFREAYDELCALQRSDRARWEEVLLRPELDAWAADCLRALSLGPAAPPDGPDGPAGLGGFLRAGVGPVLDLECDGLRWTPVVDHLGPRRVDYGRPPAGPLSTAELRGWEEQLAAAWEILVRRHRGHAAAVAACVAAVVPLHPAPGGEAVSSAARRAYGAVATSLPGDPVLLALALVHEFLHVQLGALLDLVPLHRPNGPAVHHAPWRPDLRPAGALLQGTYAHLGVASFWCAEAAAGVSERERAEEEFARWRAHTLTAAGTLLECGELTDNGREFTEELARSVRALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA36</accession>
    <name>A0A1E7NA36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7975"/>
    <dbReference type="EnsemblBacteria" id="ARF79069">
        <property type="protein sequence ID" value="ARF79069"/>
        <property type="gene ID" value="B6264_09195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37504">
        <property type="protein sequence ID" value="OEV37504"/>
        <property type="gene ID" value="HS99_0026160"/>
    </dbReference>
    <dbReference type="OMA" id="TQYIPPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="40690" checksum="E51E9408AF4DB3A8" modified="2017-01-18" version="1">MSQRRSYPNSGDFNLDDLFRPEPGQPQGQPGQPQGPTAVPPVGQPSGQPEYLGDGAHTQQQWGAAPQPGYGVPPQADPAPATQHLPPYPAGDPQSGGYPAPQPGYGVPQQAAPGYQGYPPAAQPQTQQQSGHPGQGYGQGGYAQGAHGTDGYGQGGYAQGAHGTDGYGQGGYGQADPNATQGGRPGRGGRSSNKLIIGGVVAGCAAAGILVAVLMNGGENTDKSGHKTAPVAATGSTAPGTASASGSGAPVDPEVKAQAQPLSDLLGTASDSRSSVVSAVASVQKCDKLPDSQQALTAAAGKRRELQTKLGQLKTDKLPGGQQLIEQLNAAWTASAQADDEYAAWATDAQSSCDPKKPDTGNQHYKNAVQASGTATTAKKQASSLWNTIATQTGLPSRSDGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA49</accession>
    <name>A0A1E7NA49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000481.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7999"/>
    <dbReference type="EnsemblBacteria" id="ARF79048">
        <property type="protein sequence ID" value="ARF79048"/>
        <property type="gene ID" value="B6264_09075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37524">
        <property type="protein sequence ID" value="OEV37524"/>
        <property type="gene ID" value="HS99_0026280"/>
    </dbReference>
    <dbReference type="OMA" id="PLYYRLF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24336" checksum="4B377C6EF82D0282" modified="2017-01-18" version="1">MRLESTLNEPTRPDQQPRTPSPRPGGRSARVRADVVAATLAEVAEKGYDGLTAEAVAARSGVHKATLYRRWGGIDGLVADALTASADQPWPLPDTGDLQEDLRRITQEVFSVFTDPEQSPTPTALISAAQRSDAGAAALRDFFTARHHQAAEVAERAVTRGELPAGTDGAEVIRAATAPLYYRLFVTGEALDARTAERAADAAALAARAGLFASIPTDPEPDTAPNTPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB0</accession>
    <name>A0A1E7NAB0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="6" type="ORF">HS99_0025270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006604855.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6255"/>
    <dbReference type="EnsemblBacteria" id="OEV37621">
        <property type="protein sequence ID" value="OEV37621"/>
        <property type="gene ID" value="HS99_0025270"/>
    </dbReference>
    <dbReference type="GeneID" id="57803544"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="54" mass="6423" checksum="1B7E205FFD69A930" modified="2017-01-18" version="1">MAATDVRPKITLACVECKERNYITKKNRRNDPDRLEMKKHCPRCNSHTAHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD6</accession>
    <name>A0A1E7NAD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1710"/>
    <dbReference type="EnsemblBacteria" id="ARF79903">
        <property type="protein sequence ID" value="ARF79903"/>
        <property type="gene ID" value="B6264_14205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37646">
        <property type="protein sequence ID" value="OEV37646"/>
        <property type="gene ID" value="HS99_0025420"/>
    </dbReference>
    <dbReference type="OMA" id="VISAWRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="20722" checksum="C9817476010491DC" modified="2017-01-18" version="1">MNAPRNSRLTGYAAVGAPALMALYGGIRLVPGSRQPGLGWTAGHTAMFAGLLLFVPVLLALRALLAPRGTTAGKLAANAALGTAFAGLLASLVQIGIDLYVGVVSATKEEQSRLFGRVQDVPGVLPAVYQVGPLLFYVGLLALLVAASVGAGRTLPWWSPVLMLVGTLATGVDLAFIPLAAACYLVALAPLTRPATALRPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAH9</accession>
    <name>A0A1E7NAH9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">HS99_0025660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280796.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1662"/>
    <dbReference type="EnsemblBacteria" id="ARF79948">
        <property type="protein sequence ID" value="ARF79948"/>
        <property type="gene ID" value="B6264_14450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37691">
        <property type="protein sequence ID" value="OEV37691"/>
        <property type="gene ID" value="HS99_0025660"/>
    </dbReference>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23639" checksum="ADEF5F6476579FBF" modified="2017-01-18" version="1">MRIVLVGPPGAGKGTQAHLLAKTLSIPHISTGDLFRANIGQGTPLGLEAKSYMDAGRLVPDEVTIGMAKDRMLQADAANGFLLDGFPRNLGQAKALDEFLAEQGIELDGVLDLEVPEDEVVRRIAGRRLCRNDGGHVFHVDYNPPKVEGVCDECGGELYQRSDDTEEKVRTRLEVYHTETEPIIDYYVQQGLVATISALGKVDEVTQRAIEALKQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ6</accession>
    <name>A0A1E7NAZ6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">HS99_0024990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289191.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6020"/>
    <dbReference type="EnsemblBacteria" id="ARF78024">
        <property type="protein sequence ID" value="ARF78024"/>
        <property type="gene ID" value="B6264_02990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37838">
        <property type="protein sequence ID" value="OEV37838"/>
        <property type="gene ID" value="HS99_0024990"/>
    </dbReference>
    <dbReference type="OMA" id="AGEHVPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="54" mass="6389" checksum="39C67B2F98E7569D" modified="2017-01-18" version="1">MARNELRPIIKLRSTAGTGYTYVTRKNRRNDPDRLVLRKYDPVAGTHVTFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB12</accession>
    <name>A0A1E7NB12_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000154.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2145"/>
    <dbReference type="EnsemblBacteria" id="OEV37881">
        <property type="protein sequence ID" value="OEV37881"/>
        <property type="gene ID" value="HS99_0023655"/>
    </dbReference>
    <dbReference type="OMA" id="GYIWFAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="288"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="41796" checksum="5B8E2EB68FF446FA" modified="2017-01-18" version="1">MTPADQLPSRRLPAWCTAPWLMLLLPVLYSLMDAALVARDATWWQMALSTLAAVALFWRRRFPVTVLLLTMPGTWVEAIWLAPITAVYTVATERPGARVLFPCATLFTLVSFFHWPLPTPVIDLSRNTALDAIQAVMLAAGPAATGLLSRTRRELAARLDELTRGQERESRLLAERVLISERGRLAREMHDVVSHQVSLISIQAGALQVSTADPAAAGVARTIRELSVRTLDELRQMVGVLRGTTNGPFPAAPLAPQPRLTDLPRLIEQSGLAADTELNPGDRPWPEAVERAAYRTVQEALTNITKYAPEAVVHVRVRAKGRRLRVEVRNEAPPVHPAEILPGGGHGLVGLRERAQLLGGTLTAGPTQDGGFEVRAELPASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB19</accession>
    <name>A0A1E7NB19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278236.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2135"/>
    <dbReference type="EnsemblBacteria" id="ARF79440">
        <property type="protein sequence ID" value="ARF79440"/>
        <property type="gene ID" value="B6264_11375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37890">
        <property type="protein sequence ID" value="OEV37890"/>
        <property type="gene ID" value="HS99_0023710"/>
    </dbReference>
    <dbReference type="OMA" id="YVFPWAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6463" checksum="D283D9BAA9AC477D" modified="2017-01-18" version="1">MYGWIWRHLPGNTLVRAVISLLLILGIVYLLFTYVFPWAEPLLPFGDVTVDGGDGASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB40</accession>
    <name>A0A1E7NB40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366677.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2103"/>
    <dbReference type="EnsemblBacteria" id="ARF79466">
        <property type="protein sequence ID" value="ARF79466"/>
        <property type="gene ID" value="B6264_11555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37916">
        <property type="protein sequence ID" value="OEV37916"/>
        <property type="gene ID" value="HS99_0023885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22006" checksum="1BE467F85D52574E" modified="2017-01-18" version="1">MSTPTGPYGPPPPAAPGYGPPPPAYGGQPPYGQQPTAPLPYPNPYAQNPYAQAPQAQPQPQPQAPYGQQAPYGQQPPAGPYGHPQPAPAAATPPAKRGVRSKLRIAGLVGGCAVLAGGYFLAGPSVSSAKPGDCVRVSGSRDVSIVNCNDSKANYKVLSKFTGTTDVTRCRQTPQTTSAVSGKSGRRWNKTRYVLCLGPLTPTTGGYPPVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB47</accession>
    <name>A0A1E7NB47_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="8" type="ORF">HS99_0023945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278278.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2091"/>
    <dbReference type="EnsemblBacteria" id="ARF79477">
        <property type="protein sequence ID" value="ARF79477"/>
        <property type="gene ID" value="B6264_11615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37926">
        <property type="protein sequence ID" value="OEV37926"/>
        <property type="gene ID" value="HS99_0023945"/>
    </dbReference>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15556" checksum="9AA3D04D12E5723E" modified="2017-01-18" version="1">MKIILTHEVPGLGSAGEVVEVKDGYARNYLVPRGYAIRWTKGGQKDVDAIRRARKIHEIQTLDAANDVKGKLEGVQVKLAVRSGDAGRLFGSVTQADVVEAIKAAGGPAVDKRAVAIASPIKTVGTHKVSVKLHSDVVANLDVAVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB62</accession>
    <name>A0A1E7NB62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2090"/>
    <dbReference type="EnsemblBacteria" id="ARF79478">
        <property type="protein sequence ID" value="ARF79478"/>
        <property type="gene ID" value="B6264_11620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37927">
        <property type="protein sequence ID" value="OEV37927"/>
        <property type="gene ID" value="HS99_0023950"/>
    </dbReference>
    <dbReference type="OMA" id="MDGIWLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13136">
        <property type="entry name" value="MATE_DinF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="44993" checksum="877335B050701C1C" modified="2017-01-18" version="1">MSTATSEPSGRSHDREILALAVPAFGALVAEPLFLMADSAIVGHLGTPQLAGVGVASAALTTATGVFVFLAYATTAAVARRIGAGDRRGAVQQGVDGLWLALGLAVPVVLLTLLLAPWAAGVLGASPTAAPYAVTYLRISSLGIPAMLLVLAATGVLRGLQDTRTPLVVAVAGFTANIGLNAGLVYGAGLGVAGSAWGTVLAQTGMAAVYLVVVVRGARREQASLRPDPAGIRAGARAGGPLLVRTVSLRAVLMIATAVAARLGDDQVAAHQITMTLFSFLAFALDAIAIAGQAVIGRYLGASDVPGARAATRRMVEWGVGSGVVLGLLVVLARPLYVPLFTPDPVVQGQLHTALLLLALSQPVAGLVFVLDGVLMGAGDGPYLARAALATLAVFTPAAFAVPATGTGLAGLWWAMDLFMLVRAVFLVARARGGRWLVTGAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB77</accession>
    <name>A0A1E7NB77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2052"/>
    <dbReference type="EnsemblBacteria" id="ARF79510">
        <property type="protein sequence ID" value="ARF79510"/>
        <property type="gene ID" value="B6264_11810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37956">
        <property type="protein sequence ID" value="OEV37956"/>
        <property type="gene ID" value="HS99_0024135"/>
    </dbReference>
    <dbReference type="OMA" id="AANVDCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="44385" checksum="50491C33D5B808F9" modified="2017-01-18" version="1">MRSPLRNWRRLSKPQRTEYYLRWSLYLMAVFLMPGVLFAIGTGSGAAGHSSAVQVSLLIGLATTLVLLRTFRVTLDHYLRRPAEHRRWIVLTVGLVVAGSWAVMLVGPAGDMTAKPVQFPFTALVAGYLLIFGFCPVCVGLPPRWSAPAGLGMVVAVVPAMVLAGVGAATATGFLMVMTVAMAFLGASCRSFAWLTAIVWELDAAREAQSRLAVAEERLRFSRDLHDVMGRNLTTIALKSELAVQLARRGRPEAAEQMAEVQKIAQESQREVRDVIRGYRTADLHAEAIGARAVLRAADIHCDIDLGEEPDRLPPQVQSVLGWVIRESTTNVLRHSEAARCLIRLRQEDGRAVLELENDGVPAVPLPSQGGGTGLHGLRERLAAHDGELTVPTTAPGTFRMLATVPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS0</accession>
    <name>A0A1E7NBS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288115.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000474.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7140"/>
    <dbReference type="EnsemblBacteria" id="ARF79649">
        <property type="protein sequence ID" value="ARF79649"/>
        <property type="gene ID" value="B6264_12690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38141">
        <property type="protein sequence ID" value="OEV38141"/>
        <property type="gene ID" value="HS99_0023400"/>
    </dbReference>
    <dbReference type="OMA" id="HETVRWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="36703" checksum="6E5752A32ADFBC13" modified="2017-01-18" version="1">MRTELQFSTQDLALTRFAVSPMQEVVTSLRALACSPVPALHRRWAGQVRARLAAAGLDRGRLAAMVPPDGHLPDFLNPAPAGCSTTLAEELAVITATGAEQVRADLDVLAAEAGGRLPAALTALHRDPSGQLPRLAAEIEAYWELALAPYWARIRALLAADVFHRSRQAAEHGPARMLDDLHETVRWDGTALRLERRHCAVTRLTAGAGLLLVPSAFAWPRVLTRVLPPDPPQLVYPARGTAALWEERPGSAARTDALAAVLGRSRAQLLAELDSPASTTELARRTGLSPAAVSQHLTALRAAGLTSAHRAGHTVLSARTGVGDSLFDTDGQSLDRATPAGRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCS1</accession>
    <name>A0A1E7NCS1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287787.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene337"/>
    <dbReference type="EnsemblBacteria" id="ARF82145">
        <property type="protein sequence ID" value="ARF82145"/>
        <property type="gene ID" value="B6264_27650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38458">
        <property type="protein sequence ID" value="OEV38458"/>
        <property type="gene ID" value="HS99_0021400"/>
    </dbReference>
    <dbReference type="OMA" id="ANKIEPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="41750" checksum="DB9AD048D87A8855" modified="2017-01-18" version="1">MTSENSYDDERIGRARVNDSPELLAYYEELAKHEAGALWTVANEIEPWYPQPKSVPVLWRYADLRPLVRKALPLVKADDAGRRVVMLVNPGRRELSAAVGLLYTGLQIMGPGEAMTAHRHQASALRFVHEGAGAWTVVDGQKLKVGPRDFAITPNNTWHEHGNEAEDHPVIWQDGLDIPLVNTLDANFYEVHPELYQRPGPVTNSSLLSYGGNLLPYGAEKWTRPYSPLLGWPWEPSYHALCQLARATEGSPYDGVIMEYTNPVTGGPVMPTMAAHLQLLRPGQATRAHRHTGSVVYTAAKGRGVSVIAGQRFEWQQGDIFVVPSWAWHEHANLDQGEDACLFSFNDFPVMHSLGLYREEPYPDHDGHQPTTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND00</accession>
    <name>A0A1E7ND00_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene330"/>
    <dbReference type="EnsemblBacteria" id="OEV38534">
        <property type="protein sequence ID" value="OEV38534"/>
        <property type="gene ID" value="HS99_0021370"/>
    </dbReference>
    <dbReference type="OMA" id="KFWLTLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19173" checksum="6F8160EBD7FD8143" modified="2017-01-18" version="1">MSPGARKRLVALHVVVSVSWLALMLCLLTLAVTALTTDDGDRLRTTYRAMGMLGDALVLPLSLLTFLSGVALGLGTSWGLFRYYWVSTKFWLTLGAMAASVFALTARLHDAVRVADTHPTGPIPVADLGFVRYNTVIVPAVALSLYLFNVILSVYKPWGRRKAAERRAVRIPSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND60</accession>
    <name>A0A1E7ND60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene588"/>
    <dbReference type="EnsemblBacteria" id="ARF77663">
        <property type="protein sequence ID" value="ARF77663"/>
        <property type="gene ID" value="B6264_00865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38630">
        <property type="protein sequence ID" value="OEV38630"/>
        <property type="gene ID" value="HS99_0020450"/>
    </dbReference>
    <dbReference type="OMA" id="QDPNMPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8836" checksum="15A3F168AE254EEB" modified="2017-01-18" version="1">MLRPVLLPVQFALLLFTLRLGRLRAARARGDRGAISIELALAIIALVFVAGAVATALYLLKDKVVTKVEQDPNLPGGGGAGGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG1</accession>
    <name>A0A1E7NDG1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77728">
        <property type="protein sequence ID" value="ARF77728"/>
        <property type="gene ID" value="B6264_01235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38688">
        <property type="protein sequence ID" value="OEV38688"/>
        <property type="gene ID" value="HS99_0020820"/>
    </dbReference>
    <dbReference type="OMA" id="CITTASG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="26540" checksum="7D94B901E3E9A796" modified="2017-01-18" version="1">MTAAGIGTTVLAATGITYASSSGTTPAPPPVQPAAQPAAPPAQPAAPAAAAPGGGNAGGEKAVASGGSNAGGEKAVASGGSNAGGEKNENRGHEGGEGGGHGEGGGRGHEGGGRGEGGGRGEGGGRGHEGGEHGEGGDRGEGGGRGHEGGEHGEGEHGGRGHEGGERGHRHKEGRIFFNERTFSAHTEGCITTASGLGATSFNVFNDSWKTIEVFRGFNCDHGGPVAVVGPHSSTNGVAARHFDEDESDFGGAFDCDGVVGSFRVIGHRGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI5</accession>
    <name>A0A1E7NDI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555011.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3115"/>
    <dbReference type="EnsemblBacteria" id="OEV38543">
        <property type="protein sequence ID" value="OEV38543"/>
        <property type="gene ID" value="HS99_0021770"/>
    </dbReference>
    <dbReference type="OMA" id="GLWPPRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="30385" checksum="6103F0342034E7C5" modified="2017-01-18" version="1">MVKAARPEPEPEPEPVEAEAEAAAVEPSEAAEEPPAVDRNAGRRRLQAALWPPRLSRGQLVVALLLFSLGLALAIQVRSTNDHHNQLRGARQEDLVRILDELDSRQQRLQQEKAELEQSLGKLENSSNQAKEAQEQTRKKMTELGVLAGTVKATGPGIVLTVDDPQGLVKADMLLDTLQELRAAGAEAIQINDVRVVVNTYFTDLSGGGVQIDGKKVSQPYRFTVVGNPQDLTPALNIPGGVVRTLESHQARATITQQQKVVVDALVDLKTPQYAKPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT0</accession>
    <name>A0A1E7NDT0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556336.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5132"/>
    <dbReference type="EnsemblBacteria" id="ARF81253">
        <property type="protein sequence ID" value="ARF81253"/>
        <property type="gene ID" value="B6264_22225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38849">
        <property type="protein sequence ID" value="OEV38849"/>
        <property type="gene ID" value="HS99_0019490"/>
    </dbReference>
    <dbReference type="OMA" id="LDEFHTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2293" mass="250289" checksum="C1E55CBCC6891545" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX0</accession>
    <name>A0A1E7NDX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555478.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6546"/>
    <dbReference type="EnsemblBacteria" id="ARF81315">
        <property type="protein sequence ID" value="ARF81315"/>
        <property type="gene ID" value="B6264_22565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38906">
        <property type="protein sequence ID" value="OEV38906"/>
        <property type="gene ID" value="HS99_0019830"/>
    </dbReference>
    <dbReference type="OMA" id="HPYNVSL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="36233" checksum="A3717BA6AF0EE93E" modified="2017-01-18" version="1">MPGTARPLAALSLLAACALALTACGSSGGSTDSAAPAASGTALAGQTVTVYSGQHEQTVKALTEDFTKRTGIKVELRSGDEAELANQILQEGDASPADVFYAENPPALTVLGDKGLLAKVAPDTLKSVPANDSSGRGDWVGVSARTSAFLAATGKAADSAPPASVLDLAKPEWKGRLGIAPSETDFAPVVTQVLKAKGEDATKQWLKGLKDNAKVYDSNETLSAAVNSGEVEGGVIDHYYFYRMRDEKGAAETRATLHYFPKGDPGSLVDVSGAAVLKHGKHQAAAQAFLGYLASAPAQTVIAGSASYEYPLVSGVQGKPELPALDTIGTVADPAQLGDGKQALGLLQDAGLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE43</accession>
    <name>A0A1E7NE43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386819.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7335"/>
    <dbReference type="EnsemblBacteria" id="ARF82987">
        <property type="protein sequence ID" value="ARF82987"/>
        <property type="gene ID" value="B6264_21650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38915">
        <property type="protein sequence ID" value="OEV38915"/>
        <property type="gene ID" value="HS99_0018920"/>
    </dbReference>
    <dbReference type="OMA" id="WFRLAGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17997" checksum="FB4CCD9152505346" modified="2017-01-18" version="1">MYLSWTAGRLDRLHARIDAARAALDAQLVRRASVAMELATSSLLDPAASLLLLDAAHAARQAEDEQREVAESQLSLALRAVLDEPEQVAALVAEPGGEEAVRDLTAAVRRVPMARRFHNDAVRAARAVREHRLVRYFRLAGKAPFPMAFEMDDAAPPALTPEGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE62</accession>
    <name>A0A1E7NE62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4320"/>
    <dbReference type="EnsemblBacteria" id="OEV38962">
        <property type="protein sequence ID" value="OEV38962"/>
        <property type="gene ID" value="HS99_0017770"/>
    </dbReference>
    <dbReference type="OMA" id="SRFESCQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199142" evidence="1">
        <location>
            <begin position="35"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="428" mass="46307" checksum="29396DB992E1A390" modified="2017-01-18" version="1">MNARAIHRLLRAASATACAALLAAGTLTASPAVAAQGPNASGFVPTSSVPADQLARFSSIARSPENGAETRAGTAHAAPTPAVADALADDPGLEEECAKHPEADSPTGWIKNRFEMCVHRHYDLVLATPDRSVTLGRLRFDAWVLGFAYDGQRKVDYVVSVKDIIDEPVPGEDSSKWSISQDVNFSGQGSGSVTKPDKQSRVELIGSWKQQPLWTLTYTAPDKGPLYDQGDQQIVKADLTLSMRVTSPNTRTSPWSEFGAAKSNVRFDYAGPVAGKYKGTVFTDGRAELVMKLSDPAVRESALHIKDAQNNPERTFPSFNGKSIPGAKQPLHRLIDRAKQDENRRVAIATCNEVWGDYSGSGLQCDEYPFSSTYEGANQKDSAGNLVNRYSARLIDGKDNGDGGNMIKDVFTINRILDNDPFYVTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE89</accession>
    <name>A0A1E7NE89_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83212">
        <property type="protein sequence ID" value="ARF83212"/>
        <property type="gene ID" value="B6264_30175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38984">
        <property type="protein sequence ID" value="OEV38984"/>
        <property type="gene ID" value="HS99_0017910"/>
    </dbReference>
    <dbReference type="OMA" id="LARMPCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="23834" checksum="597A6D269F031F82" modified="2017-01-18" version="1">MVGVVLAVLGVSACSADPQGRPATGAASDRTHPQARLREGLLTLDRLPQGFQLNTADVNSTTTGAPHTPSAVSIASMPCSELGVESFMTAHAHPVEDAAVGVERTPVGDDDMGWFGQESLDRYAPGQAAEVMAAIRGVAGRCASSTDTLADGTPLRDTASVTAAGVAADDSLLLHLTSAFPDGGQQFVNETAFVRMGDVILMVQHVVEDHPSSDTETVLSAAMTAYRSTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG0</accession>
    <name>A0A1E7NEG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheine--protein transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286800.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1041"/>
    <dbReference type="EnsemblBacteria" id="ARF83256">
        <property type="protein sequence ID" value="ARF83256"/>
        <property type="gene ID" value="B6264_30420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39025">
        <property type="protein sequence ID" value="OEV39025"/>
        <property type="gene ID" value="HS99_0018150"/>
    </dbReference>
    <dbReference type="OMA" id="YYCRTRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="42412" checksum="7C520CC141BF630F" modified="2017-01-18" version="1">MTAPSMPDDRDKVVTKLPQQLRRELKIRAATVGIPIQDAVTQGIQAWREAAHPLDLIDTARSDSFSTYVPSALYKGFREDCSGRGLPYNQGLAQAIRLWLDANPLPHRSRPQTGARRVAFGNQKGGVGKTAMSAGVGQALAEMGYRVCLVDFDPQGHLTKQFGHDHLPIKGDSLVKNMCGERQADLRDLLIEIPGETFGDRLHLLPACTDGFLLDAKLVSSREIRVKETALEKALTAVEREFDFVIVDCPPSLGYAMDNAIYYARTREGEPEGSSGIVIPVQAEDSSADAYTLLREQIDSLCDDLDIQVYDLGFVVNLYDVRKGYVVTSSLDAWKSLGHPEVIAVVNDLKDQREAVRMKTPLLVHAPDSDQAEVMRDIARRIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU3</accession>
    <name>A0A1E7NEU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285162.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000490.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3505"/>
    <dbReference type="EnsemblBacteria" id="OEV39192">
        <property type="protein sequence ID" value="OEV39192"/>
        <property type="gene ID" value="HS99_0000215"/>
    </dbReference>
    <dbReference type="OMA" id="VHFLYHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032962">
        <property type="entry name" value="HPA2/HPA3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF42">
        <property type="entry name" value="PTHR10545:SF42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17804" checksum="DFB1770EAE1C527F" modified="2017-01-18" version="1">MSTTAAKRWTVSAPEAGDHPAWRELFRGYCAFYRVPMPEEKAELVWSWLNDPAHELEGLLARDADGTPVGLAHFRPFSRPLHGAVGGFLDDLFVAPEVRGGGAVDELLARLREIAAERGWSTIRWITADDNHRARSKYDQVATRTMFVTYDMAPESTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF98</accession>
    <name>A0A1E7NF98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385763.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3469"/>
    <dbReference type="EnsemblBacteria" id="OEV39163">
        <property type="protein sequence ID" value="OEV39163"/>
        <property type="gene ID" value="HS99_0000045"/>
    </dbReference>
    <dbReference type="OMA" id="ELAAMYC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="16566" checksum="0A78EC054A26771E" modified="2017-01-18" version="1">MPARIHATPAQAVEAARPIVLTAFRVVVGLLFACHGVASVFGVLGGTKGGGSLPLGQWPGWWAALIQLVGGALVLLGVGTRYAALLCSGSMAYAYFTVHQEHALLPLQNGGEPSVMFCWAFLAIAVLGSGPYSLDRLLRTRQPQAAPDPVEATAAQSTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG38</accession>
    <name>A0A1E7NG38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6703"/>
    <dbReference type="EnsemblBacteria" id="OEV39585">
        <property type="protein sequence ID" value="OEV39585"/>
        <property type="gene ID" value="HS99_0002595"/>
    </dbReference>
    <dbReference type="OMA" id="VARYSYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199112" evidence="1">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_cc" evidence="2">
        <location>
            <begin position="48"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="29343" checksum="1290E45FEAC2E6D7" modified="2017-01-18" version="1">MPGRTRLFAVLLAVLTCLTVGSTADASAAPVKKKGVSAWNFTDATGALADSGVGWFFTWASDRQQIKPPAGVEFVPMIWGAASVTDAQLATARKEGTTLLGFNEPDLPAQANMNVSRALDLWPRLQSTGMRLGAPAVAGGGDVAGGWLDRFMKGAASRHYKVDFVPLHWYGSDFRADAATGQLRSYLQAVHNRYNKPIWLTEYALIDFSSGTPRYPTPEQQAAFVTKSTAMLQGLPFVERYAWFTLSADRGGTGLYNRATPNRVGTAYRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG65</accession>
    <name>A0A1E7NG65_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2777"/>
    <dbReference type="EnsemblBacteria" id="OEV39638">
        <property type="protein sequence ID" value="OEV39638"/>
        <property type="gene ID" value="HS99_0002915"/>
    </dbReference>
    <dbReference type="OMA" id="PRQPCVK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23357" checksum="7D715E37AE4B5AD1" modified="2017-01-18" version="1">MKLLSVNVGRPRPNPWKGLGATGIDKRPVDGPVAVADPGPKGTGAVGLAGDRAYDVKNHGGADQAVYAYAREDLDGWEAELGRVLSNGVFGENLTTVGLDVNGARIGERWRIGPDAVLEVSCPRIPCSTFQGWLEREGWVTRFTEAAVPGAYLRVIAPGAIRAGDPVEIVHRPDHDVTVEVVFRAMTLEPALLPLLLVADALPEQDRARVRRRMPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG66</accession>
    <name>A0A1E7NG66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367065.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2863"/>
    <dbReference type="EnsemblBacteria" id="OEV39709">
        <property type="protein sequence ID" value="OEV39709"/>
        <property type="gene ID" value="HS99_0003345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="42798" checksum="1BBCF45E91449F65" modified="2017-01-18" version="1">MSPTAFPAAETATAPAPAVDPGPELDGGDFTLPEGGLDDDRRLRALDAVDEYLTRKRKHLVGYQATQDMQGTALDLARFMPNNINNLGDPFQSGGYKPNTKVVERAVLDYYAKLWHAERPHDPADPESYWGYMLSMGSTEGNMYALWNARDYLSGKALIQPPTAPFDAVRYVKADPDRRNPNAHHPVAFYSEDTHYSFAKAVAVLGVETFHAVGLEKYADECPLVDPVTGLRTWPTEVPSRPGPSGLSWDGPGEIDVDALAVLVEFFAAKGHPVFVNLNLGSTFKGAHDDVRAVCERLLPIFERHGLVQREVVYGSCPQTGRPLVDVRRGFWIHVDGALGAGYAPFLRLAAEDPEGYGWTPEAELPEFDFGCGCPPPDTARWTWSPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SB36</accession>
    <name>A0A176SB36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038870</name>
        <name evidence="3" type="ORF">HS99_0038890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291361.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000199_gene4211"/>
    <dbReference type="EnsemblBacteria" id="ARF78586">
        <property type="protein sequence ID" value="ARF78586"/>
        <property type="gene ID" value="B6264_06385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82665">
        <property type="protein sequence ID" value="ARF82665"/>
        <property type="gene ID" value="B6264_06365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33285">
        <property type="protein sequence ID" value="OEV33285"/>
        <property type="gene ID" value="HS99_0038870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33292">
        <property type="protein sequence ID" value="OEV33292"/>
        <property type="gene ID" value="HS99_0038890"/>
    </dbReference>
    <dbReference type="OMA" id="SDGFPRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14276" checksum="635E669791B29F7C" modified="2016-09-07" version="1">MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLCMSEGFPRDRADQLAAVASGLTSLTSGASRIFEGGEVNQTVVEMERGFLFLMAISDGSALAVLAAPDSDIGLVGYEMALLVDRAGAVLTPALRAELQGSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV41</accession>
    <name>A0A1E7MV41_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0016465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GmhB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738028.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6880"/>
    <dbReference type="EnsemblBacteria" id="OEV32302">
        <property type="protein sequence ID" value="OEV32302"/>
        <property type="gene ID" value="HS99_0016465"/>
    </dbReference>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="21882" checksum="2403267F04832096" modified="2017-01-18" version="1">MTSATGRAPSGVRPPHGRTRPAGPWIFPGCPRPGRAAGAVLFDRDGTLVEDVPYNGDPDLVRPVPGAVRAVAELRAAGLVLGVVSNQSGVARGLLTRRQVEAVQRRIDDLIGPFGIWAVCPHGPSEGCRCRKPAPGLVLAACRGLGVPPARTVVIGDIGADVGAARAAGARAILVPTPATRPEEITDADTVAADLTAAVRLVLGARPGTDREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL7</accession>
    <name>A0A1E7MVL7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385482.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6881"/>
    <dbReference type="EnsemblBacteria" id="OEV32303">
        <property type="protein sequence ID" value="OEV32303"/>
        <property type="gene ID" value="HS99_0016470"/>
    </dbReference>
    <dbReference type="OMA" id="VLTSFHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="35102" checksum="C6C64429F380AC9C" modified="2017-01-18" version="1">MTTLVVRLDSAGDVLLAGPAVRAAAHHSRRVVMLCGPQGAPAARLLPGVDEVVVWDSPWTGFDPPPATARGVMDLVSSLASRTIERALVLTSFHQSALPTALLLRMAGVAHIAADSVDYPGSLLDLRHQRGEGRHEAEAALDLAAAAGFPLPPGDDGRLAVLPPPGQQHLTGPGRYVVLHPGAAVPARAPGARLAAAAVRALAAAGHRVVVTGGRAEKELTAEVAGADALDLGGRTGLAELSGVLAGADVVVAGNTGPAHLAAAVGTPVACLFAPVVPAHRWRPYGVPHVLLGRQDAPCAGTRARTCPVPGHPCLDSLTAEEIVTAVDLLRNPPTTTERPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS7</accession>
    <name>A0A1E7MVS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0017240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1171"/>
    <dbReference type="EnsemblBacteria" id="OEV32529">
        <property type="protein sequence ID" value="OEV32529"/>
        <property type="gene ID" value="HS99_0017240"/>
    </dbReference>
    <dbReference type="OMA" id="LWDPDQI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="446" mass="47562" checksum="9CB1FA93CA7B46D9" modified="2017-01-18" version="1">MARAHRPALMPAATDLPPGGESARRAVEAVWRIESARIVGALARYTGDFALAEDVAQEALAQALVSWERDGPPASPVGWLLATARRRAIDAFRRASALDERYAALAGPLAEGEFSAGAAGAPQQPDDLPWDPDRVDDDVLALMFTACHPVLSPEARVALTLRVVGGLSSEEIARAFLVPVPTVQARITRAKKTIAAAHVPFELPPQQERRTRLGAVLSVLYVIFTEGSTATAGEDLLRPDLAHEALRLARMLAALLPCEPEVHGQLALFELTAARFPARTGPDGEAVLLEDQDRRRWDRSAIRRGLAALGRAASLGRGLGPYGLQASIAACHAAAPSVARTDWERIVLLYEALGRVAPSPVVELNRAVAVAMAEGPRQALALVDDLAVSGRLSGSHLLPGVRGELLARLGRTAEARAELELAARLCRNTRERAVLLRKAAALDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS0</accession>
    <name>A0A1E7MWS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000080">
        <property type="protein sequence ID" value="OEV32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000116_gene4538"/>
    <dbReference type="EnsemblBacteria" id="OEV32877">
        <property type="protein sequence ID" value="OEV32877"/>
        <property type="gene ID" value="HS99_0039670"/>
    </dbReference>
    <dbReference type="OMA" id="WWWSATT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28588" checksum="90643EB4E037CD18" modified="2017-01-18" version="1">MDGRAGFEAVFLDPVGQEVRQRWEDACVAVAFENLAPVSAFPVVPGRRWGPGLWWSATTGRHVASGSNAMRARLMVLDRDPQVTGLAGRPVRLVWRDRRGRVRSWVPQLFARYADGTALVADCPGHAEAGGERALRAEQAARAACDLVGWRYRRLEPLDAVFAANLRWLAGYRHPRYRGRPGVGDALLEAFARPRPLLEGVQALGTPMTVLPAVFHALWHGWLAVSLERPLHQGVLVGPGSVRAMAGSSGMGTAGVADDCGGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX5</accession>
    <name>A0A1E7MWX5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">HS99_0013755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279990.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5770"/>
    <dbReference type="EnsemblBacteria" id="ARF81355">
        <property type="protein sequence ID" value="ARF81355"/>
        <property type="gene ID" value="B6264_22775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32945">
        <property type="protein sequence ID" value="OEV32945"/>
        <property type="gene ID" value="HS99_0013755"/>
    </dbReference>
    <dbReference type="OMA" id="TFCVGQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21789" checksum="0F4887F4EF276475" modified="2017-01-18" version="1">MGSYTVPYVIERTAKGERTYDVFSRLLNERIIFLGTEIDDGVANVVIAQLLHLESENPEREISIYLNSPGGSFTSLMAIYDTMTFVQAPISTFCVGQAASTAAVLLAGGDPGRRFVLQHARVLLGQPASGGRRGMVSDLSLAAKEMVRIRSQVEEVLSRHTGHDVATLRADMDREKVLTAEEAVAYGLADEVLSRRLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX04</accession>
    <name>A0A1E7MX04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279952.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000556.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5750"/>
    <dbReference type="EnsemblBacteria" id="ARF81373">
        <property type="protein sequence ID" value="ARF81373"/>
        <property type="gene ID" value="B6264_22880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32960">
        <property type="protein sequence ID" value="OEV32960"/>
        <property type="gene ID" value="HS99_0013850"/>
    </dbReference>
    <dbReference type="OMA" id="FLMRQSL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="29935" checksum="F9EF2B28EB84E9B7" modified="2017-01-18" version="1">MNRVKLRGWPLTFLLAGLTGLSVAPFYWLLISTTRKDTEIFDWPPHLLPGGGLGANLHRLDERIGLLRAIANSLLVAGIQTVGALVVALLAGYAFAKFRFRGRTLLFALLLSTLVVPEQVMLVPLFKMMTSFGLLDSYQAIILPGLCVPFAVFLMRQSLAGLPDELLDAARVDGAGEFRVLWNVVVPVMRPVLAALSIFLFLGSWNQFVWPLIALRSPDMHTLPVALATLYGNKATTDYGAILSGTALSTLPMMVLFLVLQRQFISGLLAGATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX61</accession>
    <name>A0A1E7MX61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279833.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5676"/>
    <dbReference type="EnsemblBacteria" id="ARF81442">
        <property type="protein sequence ID" value="ARF81442"/>
        <property type="gene ID" value="B6264_23255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33026">
        <property type="protein sequence ID" value="OEV33026"/>
        <property type="gene ID" value="HS99_0014225"/>
    </dbReference>
    <dbReference type="OMA" id="QECSIAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19308" checksum="3833AB0FC1772991" modified="2017-01-18" version="1">MALGTDYELQDCALARALEVVGERWSLLIVRDAFYGVQRFNDFLTHLGIPRAVLTARLNALVAAGVLRREPYQQAPLRHGYLLTETGLELWGPLYQLSRWGGRHATEGGPHHLFAHARCGTDLDLVGACPKCGGGPVPPAEVVMRPNPAHTGGHRDDPVSRALVRSHLLLEPIASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXG0</accession>
    <name>A0A1E7MXG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2669"/>
    <dbReference type="EnsemblBacteria" id="OEV33140">
        <property type="protein sequence ID" value="OEV33140"/>
        <property type="gene ID" value="HS99_0014930"/>
    </dbReference>
    <dbReference type="OMA" id="DYKLHQS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="414" mass="45382" checksum="9FD9EFE7F0A91819" modified="2017-01-18" version="1">MTTDAIPVPELAPEAVEQWRAEEAQLVELLARAQRGIGGIAAFRLGPTPTVLVTDPAAVQHVLGRHPDRYVKRSHRARMLVGNGVLSATGDAWKRQRRLLQSQFTGPGMRRYERRIAAAARRTAQRWEGYRRSGKTFDVGEEMRGFALDTVWRALTGLELDDRTDTELRSVERVVAAMPTLPTNAADARDAVAEDLARIDAVARAAIEAARTSDAPEPGVLRVLIDAAEQHPEYTDQLIRDELVTLLVAGHETTATTLTWLFLLLDGNPGARDADPHALVSETLRLYPSAWMLPRHAVEDDVIAGHRIAAGTDVLVCPYLTHRDPALWPDPERFDPTRFSPGATRPTQLGAYLPFGLGARACLGTQFALRETTALLELLLPLGPLEFQSRPDGQAFSITVRPDGPTPAVLRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ2</accession>
    <name>A0A1E7MXQ2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">HS99_0039460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene12"/>
    <dbReference type="EnsemblBacteria" id="ARF78125">
        <property type="protein sequence ID" value="ARF78125"/>
        <property type="gene ID" value="B6264_03625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33181">
        <property type="protein sequence ID" value="OEV33181"/>
        <property type="gene ID" value="HS99_0039460"/>
    </dbReference>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32410" checksum="43E5EC19B8DF2ED7" modified="2017-01-18" version="1">MSDEERTVFLIAHTGREAALRSVEGLVHGLLKAGLRIRLLEAEAVDLDLPEGVEEVAEGPGAADGCELILVAGGDGTLLRGAELARSHGLPMLGINLGRVGFLAEAERDDLAVVVERVVEADYEVEERMTIDVIVRTNGDVVHQDWALNEASIEKASRERMLEVVTEVDGRPVSNFGCDGVVCATPTGSTAYAFSGGGPVVWPEVEALLMVPISAHALFARPLVTSPDSVLAVEVQPKTPHGVLWCDGRRSVELPAGARVEVRRGQTPVRLARLHRAPFTDRLVAKFALPVTGWRGRSNHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU1</accession>
    <name>A0A1E7MXU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387346.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000834.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5914"/>
    <dbReference type="EnsemblBacteria" id="ARF82076">
        <property type="protein sequence ID" value="ARF82076"/>
        <property type="gene ID" value="B6264_27205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33239">
        <property type="protein sequence ID" value="OEV33239"/>
        <property type="gene ID" value="HS99_0039155"/>
    </dbReference>
    <dbReference type="OMA" id="HRPRMKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="32522" checksum="6C5EE6032033DE46" modified="2017-01-18" version="1">MPTAPPPDFAAALAAGPLVLDGGMSNQLAAAGHDLSDALWSARLLADDPEAVVAAHRAYFAAGAEVAITASYQASFEGFARRGVGHAAAARLLASSVELAREAVRAEPGGRRRWVAASVGPYGAVLADGSEYRGRYGLSHAELVAFHRPRLEVLAVARPDVLALETVPDADEARALLELVRGIGVPAWLSYSVADGRTRAGQPLAEAFALAAEVDEVLAVGVNCCTPRDADLAVAVAAEVTGKPVVVYPNSGERWDADRRDWRGEPTFRSARVGGWLADGARLVGGCCRIGTDGIAALAAEVAVRRGVLSGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY69</accession>
    <name>A0A1E7MY69_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0039475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290935.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene15"/>
    <dbReference type="EnsemblBacteria" id="ARF78123">
        <property type="protein sequence ID" value="ARF78123"/>
        <property type="gene ID" value="B6264_03610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33183">
        <property type="protein sequence ID" value="OEV33183"/>
        <property type="gene ID" value="HS99_0039475"/>
    </dbReference>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="581" mass="61172" checksum="7FED40524A566994" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY71</accession>
    <name>A0A1E7MY71_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366800.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4005"/>
    <dbReference type="EnsemblBacteria" id="ARF80490">
        <property type="protein sequence ID" value="ARF80490"/>
        <property type="gene ID" value="B6264_17635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33387">
        <property type="protein sequence ID" value="OEV33387"/>
        <property type="gene ID" value="HS99_0012410"/>
    </dbReference>
    <dbReference type="OMA" id="EMHARAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="26686" checksum="D701D5B4190A7115" modified="2017-01-18" version="1">MSARAAKAWRLTGVLTVVFVVVMGGAQALATVARQDRTEQQTYTASIHKLQLSTSSAAVKIKAGAEDRVVMRKNLDWTVSEPQVRADFVGDTMTVGVTCRRSLPFFNCGASIELEVPTGTSVSGSVTSGAVEVKDLTGEVRLDGTSGAITLRRLTGPVYAHATSGQVEGEDLASDRVDAASTSGAVDLTFSSAPQDVKVRTVSGGVTVSVPKGSHYRINGRTGSGNSDIDAALGDAASTNTLDTEVGSGSLWIGYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYD6</accession>
    <name>A0A1E7MYD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0012705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288780.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6567"/>
    <dbReference type="EnsemblBacteria" id="ARF80539">
        <property type="protein sequence ID" value="ARF80539"/>
        <property type="gene ID" value="B6264_17930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33434">
        <property type="protein sequence ID" value="OEV33434"/>
        <property type="gene ID" value="HS99_0012705"/>
    </dbReference>
    <dbReference type="OMA" id="EVGWLLQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028157">
        <property type="entry name" value="PELOTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011215">
        <property type="entry name" value="PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15608">
        <property type="entry name" value="PELOTA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11202">
        <property type="entry name" value="PRTase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRTase_2" evidence="3">
        <location>
            <begin position="32"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="1">
        <location>
            <begin position="265"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PELOTA_1" evidence="2">
        <location>
            <begin position="738"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="837" mass="88617" checksum="42E1BA1A69EA8C28" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYH7</accession>
    <name>A0A1E7MYH7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549914.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5166"/>
    <dbReference type="EnsemblBacteria" id="ARF80599">
        <property type="protein sequence ID" value="ARF80599"/>
        <property type="gene ID" value="B6264_18315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33495">
        <property type="protein sequence ID" value="OEV33495"/>
        <property type="gene ID" value="HS99_0013095"/>
    </dbReference>
    <dbReference type="OMA" id="VWAVQNS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="42283" checksum="78320D1EEBE1FF42" modified="2017-01-18" version="1">MTDQHNTAPAVWDPTARGGAGGWVRNPQRPDAESAPAAPQEAPTAGAVGDQGPPLGARPYLSTAPGFGPPPDMSAPAPAPAPAPAPTAAAPEPGPGAPTTALPRVTAPPPGAPPFPSPATPQDRGPQGGPLPGPGYVYPPPPTVGPYQQGPYAQAPHQQPGYGAQSYPTQPDHPTDRPLEDEDDRERPASRRAPLLIGFALLLVVAVGGGLLYAAKSGGENDRAAPAPSAAGATGSGNPQPAPAPTGTDAAPGTTAAPSDTPSPTASGAGPKAQAEAQSLDALLTEGGNARTQIGNAVAKVTSCPSKADIDSAAQVFDSGAKQRDGLLAKLGRLSVTDLPGGADAVNSLKSAWQLSSDIDKAYASWARAVAAQGCSGTAPTTADKKKADELNPQATQAKNDFLTKWKPIANAYGLTAPTSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ3</accession>
    <name>A0A1E7MYJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5165"/>
    <dbReference type="EnsemblBacteria" id="OEV33494">
        <property type="protein sequence ID" value="OEV33494"/>
        <property type="gene ID" value="HS99_0013090"/>
    </dbReference>
    <dbReference type="OMA" id="GTNRKEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198555" evidence="3">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="4">
        <location>
            <begin position="199"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="33953" checksum="F1E494062E1DFB50" modified="2017-01-18" version="1">MTGPTSRPPRRSALLRATTVVAAVVPLCTAGWFGWRALDHSDPAAATAAPPSAVQSGAVQSGSQAPDTPQSPPTSSAPSGSTPTGGAPTGTPTGTAAAPGDTPAPSAAADLTGRTIVLDPGHNPGNFAHPTEINRQVDVGNGHKECDTTGTETDAGYTEADYTLDVTRRARALLTARGAKVVFTQDGDRPWGPCVDERARAGADAHADVALSVHGDGGPASGSGFHVILPAKVVAGKADNSAIVEPSHRLGLLLRDGFHAATGEPYADYIAHDGLDTRSDLGGLNLSAVPKVFIECGNMRNSADARRMTDPQWRQQAAQGIADALTAFLTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYN3</accession>
    <name>A0A1E7MYN3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Alpha-amylase</fullName>
            <ecNumber evidence="4 9">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0013430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549968.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5235"/>
    <dbReference type="EnsemblBacteria" id="ARF80656">
        <property type="protein sequence ID" value="ARF80656"/>
        <property type="gene ID" value="B6264_18650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33552">
        <property type="protein sequence ID" value="OEV33552"/>
        <property type="gene ID" value="HS99_0013430"/>
    </dbReference>
    <dbReference type="OMA" id="FRYAYDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="578" mass="60835" checksum="650816EBC364029E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ8</accession>
    <name>A0A1E7MYQ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR01777 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282705.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000868.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5259"/>
    <dbReference type="EnsemblBacteria" id="ARF80677">
        <property type="protein sequence ID" value="ARF80677"/>
        <property type="gene ID" value="B6264_18770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33572">
        <property type="protein sequence ID" value="OEV33572"/>
        <property type="gene ID" value="HS99_0013550"/>
    </dbReference>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="31946" checksum="FA81D3F79627E759" modified="2017-01-18" version="1">MRIAVTGSTGLIGSALVRSLLADGHQVVRLVRHRSRTGPQPDGSTAIGWNPLLGEVDRDGLAGVEAVVHLAGAGVGDRRWSDSYKRDIRESRVYGTETVAVALAALKEPPRVLVSASAVGWYGQTGDRVIDEDSPAGDDFLAEVCLEWEAAARPAERAGIRVVHPRTGMVLSAAGGAGSRLFPLFKLGLGGRLGSGQQYWSYISLADEVAALRFLIDREDLSGAFNLTAPEPATNAELTAAIGRALRRPTPFPVPEAVLKVVLGELAVEVVGSHRVVPRRLLEAGFRFAHPDLDSAVRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR9</accession>
    <name>A0A1E7MYR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4024"/>
    <dbReference type="EnsemblBacteria" id="OEV33582">
        <property type="protein sequence ID" value="OEV33582"/>
        <property type="gene ID" value="HS99_0012315"/>
    </dbReference>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198558" evidence="4">
        <location>
            <begin position="36"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34058" checksum="2DCBE3E5EA3A944E" modified="2017-01-18" version="1">MIGLPGRRTRTTIALTATALAASLALTACGGSSSAKGTDGKLNVVASFYPMEFLAQQIGRDHVSVTDLTAPGVEPHDLELTAKQVAGVQKADAILYLKGLQPTVDQAVDQSSARTKIDATAASPLVDHHLDEGAEGGDTHQGKGPAGDPHIWLDPARYAAIAKGVGDGFAKADPAHAEDYRKNTDELVTRLTALDQEFQAGLKDARTRTFVTSHAAFGYLADHYGLTQVAINGVDPESEPTPARLAEVQKAAKDNGVTTIFFETLVSPKLADTVAKDLGLKTAVLDPLEGVKDPSKDDYLTVMKQNLANLRAALGAPSTTPTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ09</accession>
    <name>A0A1E7MZ09_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="11" type="ORF">HS99_0038470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280929.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000505.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4941"/>
    <dbReference type="EnsemblBacteria" id="ARF80009">
        <property type="protein sequence ID" value="ARF80009"/>
        <property type="gene ID" value="B6264_14800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33672">
        <property type="protein sequence ID" value="OEV33672"/>
        <property type="gene ID" value="HS99_0038470"/>
    </dbReference>
    <dbReference type="OMA" id="TKGMERG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="34696" checksum="7A68830DA8D7E0F6" modified="2017-01-18" version="1">MTRTPVNVTITGAAGQIGYALLFRIASGHLLGADVPVNLRLLEIPQGLKAAEGTAMELVDCAFPLLRDITITDNPNEAFDGANVALLVGARPRTAGMERGDLLQANGGIFGPQGKAINDHAADDIKVLVVGNPANTNALIAQRNAPDVPAERFTAMTRLDHNRAVGQLSAKTGALVSDIKRVTIWGNHSATQYPDIFQAEVAGKPAFEAVGNDQAWLENDFIPTVAKRGAAIIEARGASSAASAANAAIDHVYTWVNGTAEGDWTSMGVVSDGSYGVPAGLISSFPVTTKDGKFEIVQGLEISDFSRARIDASVKELTEERDAVQELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ80</accession>
    <name>A0A1E7MZ80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288047.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7710"/>
    <dbReference type="EnsemblBacteria" id="ARF78576">
        <property type="protein sequence ID" value="ARF78576"/>
        <property type="gene ID" value="B6264_06290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33736">
        <property type="protein sequence ID" value="OEV33736"/>
        <property type="gene ID" value="HS99_0037985"/>
    </dbReference>
    <dbReference type="OMA" id="MQATSFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7919" checksum="48EED4E7066356C8" modified="2017-01-18" version="1">MQATAFTFDPATRAGSVLLDDGTPVPFDAAAFDAGGLRLLRPGQRVRIRTEGTGEARRVVFVTLQTFPDPADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ97</accession>
    <name>A0A1E7MZ97_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="16" type="ORF">HS99_0038080</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288015.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7691"/>
    <dbReference type="EnsemblBacteria" id="ARF78556">
        <property type="protein sequence ID" value="ARF78556"/>
        <property type="gene ID" value="B6264_06190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33754">
        <property type="protein sequence ID" value="OEV33754"/>
        <property type="gene ID" value="HS99_0038080"/>
    </dbReference>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="31945" checksum="7037751DE8E5BE7B" modified="2017-01-18" version="1">MPELPEVEVVRRGLANWVTGRTVGDVQVLHPRAVRRQPAGAADFTARLTGTTLGTAQRRGKYLWVPLSGTGTGFSLIGHLGMSGQLLVQDPTAADETHLRVRLRFTDGGRELRFVDQRTFGGLAVEEAEEGDPEGTPVSIAHIARDPLDPRFDDAAFVAALRARRTTVKRALLDQTLISGVGNIYADEALWRSGLHYDRPTATVTRPQAALLLANARDVMTAALAVGGTSFDSLYVNVNGESGYFSRDLDAYGREHEPCRRCGTAIRRAAWMNRSSYFCPRCQRVPRLRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB5</accession>
    <name>A0A1E7MZB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional 3'-5' exonuclease/DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3770"/>
    <dbReference type="EnsemblBacteria" id="ARF78404">
        <property type="protein sequence ID" value="ARF78404"/>
        <property type="gene ID" value="B6264_05245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33776">
        <property type="protein sequence ID" value="OEV33776"/>
        <property type="gene ID" value="HS99_0037850"/>
    </dbReference>
    <dbReference type="OMA" id="EVIVHCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="575" mass="61339" checksum="0098DAA3D6779606" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN2</accession>
    <name>A0A1E7MZN2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1832"/>
    <dbReference type="EnsemblBacteria" id="ARF77742">
        <property type="protein sequence ID" value="ARF77742"/>
        <property type="gene ID" value="B6264_01310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33899">
        <property type="protein sequence ID" value="OEV33899"/>
        <property type="gene ID" value="HS99_0010470"/>
    </dbReference>
    <dbReference type="OMA" id="FICNHLS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="24214" checksum="E3C36A55A772B3CF" modified="2017-01-18" version="1">MLDLATRLVLKPVSRGIWRPVIEGIENVPRKGGVILASNHLSFIDSVVIPLTAPRRVHFLAKAEYFTGTGLKGRVSKGFFEAIGAVPVERGTYRSAQASLESALEILEDGKAFGIYPEGTRSLDGRLYRGKTGVAWLALTAGVPVVPVALEGPEQILPIGKRVPRIKKVTVRFGEPLHFDELHGQARSLKARRQVTDEVMAAIQRLSGQEVVESYNEIPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZX8</accession>
    <name>A0A1E7MZX8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280228.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000710.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2217"/>
    <dbReference type="EnsemblBacteria" id="ARF77844">
        <property type="protein sequence ID" value="ARF77844"/>
        <property type="gene ID" value="B6264_01900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33986">
        <property type="protein sequence ID" value="OEV33986"/>
        <property type="gene ID" value="HS99_0011055"/>
    </dbReference>
    <dbReference type="OMA" id="VNCHLHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24967" checksum="5721C9616DCA5148" modified="2017-01-18" version="1">MHTIRRLDLGYFVRPASEVGGPEPRVEPVLAYLVRGPQGLLLFDTGIGAGSPETEAHYRPVRRPLPEALAAAGVSVSDVDLVVNCHLHFDHCGGNPLFAGTPVLVQSNELATARRGDYTIDALVDFPGAVYRELDGETEIWPGVRVLPTPGHTDGHQSMLVERLGDCTVLLAGQAYDFATEYGQALLARRAAREGVAAPLPGYRAWLDRVAEHAPRRVLFAHDHAVWEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V0</accession>
    <name>A0A1E7N0V0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386349.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7641"/>
    <dbReference type="EnsemblBacteria" id="ARF78486">
        <property type="protein sequence ID" value="ARF78486"/>
        <property type="gene ID" value="B6264_05765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34304">
        <property type="protein sequence ID" value="OEV34304"/>
        <property type="gene ID" value="HS99_0036615"/>
    </dbReference>
    <dbReference type="OMA" id="QIISEVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27540" checksum="C868E01C1D953303" modified="2017-01-18" version="1">MRLLLVEDDERVAAALVAVLGRHGFQVRHARSGHEALDALVPDGNEPYRVVLLDLGLPDRDGFEVCSRIRAGSGVPVIMVTARADIRSRIHGLNLGADDYVTKPYDMGELLARIHAVARRGAQPSSVAVPPLDAVPQQRGPLESRGIRIDRERRRVSVDGRDVPLTRKEFDLLALLAQSPGVVYRREQIFSEVWRSGWEGNGRTLEVHIGSLRNKLALPGLVEAVRGVGYRLIPDSPTSTAADQAPSAPAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0X7</accession>
    <name>A0A1E7N0X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551341.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000588.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6412"/>
    <dbReference type="EnsemblBacteria" id="ARF78721">
        <property type="protein sequence ID" value="ARF78721"/>
        <property type="gene ID" value="B6264_07135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34332">
        <property type="protein sequence ID" value="OEV34332"/>
        <property type="gene ID" value="HS99_0036400"/>
    </dbReference>
    <dbReference type="OMA" id="FVTYIND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="32689" checksum="6E2B80B15468B2C6" modified="2017-01-18" version="1">MRTTTARRLLAATALLPVLALAACGSDPKIAGAAGASGPAATATEDVVSGLGRSEAAAALLPEEVRKSGVLKFGSSVGAPPSAFYADQASKKAVGVDIDFTDAVAKLLGLTVQREDAAFETILPALGSGKYDVGTGNFGVTTARLKTVDFVTYIDDGQGFAVRKDNTAVQPVTDLAQLCGLTIGTGAGTTFETTLNSKRAVCTDAGKKPYEVKAFSEGGALLTGLQQGRVDVEMSTINGLRHQASQEAAGVRFLNEFHRLDVGFAFKKGSPLTPAFQAAVNQLIKDGTYERILRKWGLTDSAIKESQISPPEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N114</accession>
    <name>A0A1E7N114_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3928"/>
    <dbReference type="EnsemblBacteria" id="OEV34374">
        <property type="protein sequence ID" value="OEV34374"/>
        <property type="gene ID" value="HS99_0036250"/>
    </dbReference>
    <dbReference type="OMA" id="ICMAALE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25376" checksum="B026DEDAC70C460F" modified="2017-01-18" version="1">MNVRRPSGLLTGLPRALRTYPRRSPLTLVYVVLLLLGHAWVEYGLSGQQADDLRGYISTNLDNLHDHPVRALIGSALLYDGTLTDIASTGFGGTLITLGLGIVVGLAWAERRYGTPRAAAVFLAGHVGATLITALVILLALHQGWYPADVREASDYGISYGAQASLAFAVLALPRWVRLPWAAFVLAWPLAGDHEWPGPIPEFTTVGHLLAAALGFTLAATTAAHHRRTTALATASSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N132</accession>
    <name>A0A1E7N132_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557812.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000891.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7201"/>
    <dbReference type="EnsemblBacteria" id="ARF79218">
        <property type="protein sequence ID" value="ARF79218"/>
        <property type="gene ID" value="B6264_10090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34399">
        <property type="protein sequence ID" value="OEV34399"/>
        <property type="gene ID" value="HS99_0035910"/>
    </dbReference>
    <dbReference type="OMA" id="KGECAGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="27978" checksum="FC9C856023FE2AFB" modified="2017-01-18" version="1">MLSKRLASTAAICLLLGAGTAACGDNKASDKAAAPATGAAAAATPTAAQLDTDKLSAQEIEKKAKDALASATSLRISGKMTSDDGVMTIDMVMDSKGQCRGTMALPGMGSFEMISDGTAYFMKPDTQFWKTFGGSNPAVLAKLENRYLTGFQNDPKMKDMTDFCKLADASNQMLDEGSSTPSKGSAGTVNGIKTFSLKEKDDQGEESTLHIATEGKFYPVRLEKTTGKDQGQINFTDFDKPVTVQAPPASSVIDYTKFQETVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q7</accession>
    <name>A0A1E7N1Q7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34403">
        <property type="protein sequence ID" value="OEV34403"/>
        <property type="gene ID" value="HS99_0035940"/>
    </dbReference>
    <dbReference type="OMA" id="LYGHINT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="30319" checksum="D44884EB5F595374" modified="2017-01-18" version="1">MASTHTPAHPAGPAAGTQLLDHPGPNGSEARDSAARGSDHAGAAGTAGHGDPFAPEAESSRHRLPRQTRGASPLLGVTAVAATLGATGFAAATPAAAPAVEAPDETPVALAADPGLALAARIQQQADSQRTAAEESARLQAAQEAEAKAAAKEAEAKRAAEEAERAKAAALTLPVKDYNLSAHYGQSARYWAHLHTGLDFAADTGTAVYAVGQGTITSAGWSGAYGYRIVETLPDGTEIWYCHLSSIIKGSGEVTSGQQIGKVGATGNVTGPHLHLEVRPGGGAPVDPEPWLQQHGLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1S0</accession>
    <name>A0A1E7N1S0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0009075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835577.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34639">
        <property type="protein sequence ID" value="OEV34639"/>
        <property type="gene ID" value="HS99_0009075"/>
    </dbReference>
    <dbReference type="OMA" id="FAFCPRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1074" mass="115559" checksum="49D5A2C11BC0967C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N236</accession>
    <name>A0A1E7N236_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4623"/>
    <dbReference type="EnsemblBacteria" id="OEV34735">
        <property type="protein sequence ID" value="OEV34735"/>
        <property type="gene ID" value="HS99_0009630"/>
    </dbReference>
    <dbReference type="OMA" id="KHTITEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="13514" checksum="48EA676F537C710D" modified="2017-01-18" version="1">MLEKIRVPRIGRGRPRKKPDSLAADKASSNGPCRAYLRRRGIRHTIPEKTDSQAARLRKGSRGGRPPGFDEDRYKKRNTVERAINKLKNSRAVATRYDKRGYVYLGTVTAAALVIWLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N266</accession>
    <name>A0A1E7N266_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mucin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555805.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4583"/>
    <dbReference type="EnsemblBacteria" id="ARF81865">
        <property type="protein sequence ID" value="ARF81865"/>
        <property type="gene ID" value="B6264_25910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34772">
        <property type="protein sequence ID" value="OEV34772"/>
        <property type="gene ID" value="HS99_0009845"/>
    </dbReference>
    <dbReference type="OMA" id="CRGMLAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="47590" checksum="4EC8C26056DA5DC5" modified="2017-01-18" version="1">MRYAPPGLCLNDFAVLPGDDGYTVLHLQGPWTDPFDAIKAETSYGRATSPDLVHWRPQGGAFGVGLPGRFDEHAVWTMHPVPDGNGTAMFYTGVTTLPSGGPLQSVGLARSDRADGTGWRRHGTEPVVRADPRWYRTGEGMAWRDPFVVRDDDGTGWVMVVCASDAALPFERGGCVGLATSDDLEHWQVHPPLLSPGDVDEFECPVLERLEDGWLLLGSIGATRHIEAWTAPHLDGPWVRRGPLGPPLAYAPRVVTAPDGARVVLHTVPRRVGLQDSGATCRGMLAQPKALTRADDGAPRLTWWPGLDGWLDEPGEQAVLHAVGDVAVAGPTEVVLRTGVDGAPALTVRWADGRLGVQGPGDAVLASTELPDEPRRLRILTVGEYVELYADDAFVLVALSYTGSSCRWTVTRGGATHTVPVRPVRLPDEQRDDASALWPGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P5</accession>
    <name>A0A1E7N3P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282865.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5335"/>
    <dbReference type="EnsemblBacteria" id="ARF80742">
        <property type="protein sequence ID" value="ARF80742"/>
        <property type="gene ID" value="B6264_19150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35318">
        <property type="protein sequence ID" value="OEV35318"/>
        <property type="gene ID" value="HS99_0033210"/>
    </dbReference>
    <dbReference type="OMA" id="CHGVLEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="26130" checksum="7B84DD605A13D1A6" modified="2017-01-18" version="1">MYPTRPRSALRTAVVWEVVRTALEKRAAELDQPVLDVVDTGGGTGNFAVPVAKLGHRVTVVDPSPDALFALERRAAEAGVTDLVRAVQGDTQTLPELVAPGTVDAVLCHGVLEVVDDPAEALGSLAATLRKGGLVSLLAANRNGAVLARALAGHFTEARTVLSAVDGRWGEQDPMPRRFTGEELGRLAEGAGLRVESVHGVRVFADLVPGILVDTEPGAMEALLKLEEAAAAQPAFHAVATQLHLLATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q7</accession>
    <name>A0A1E7N3Q7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name evidence="2" type="ORF">HS99_0033005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5294"/>
    <dbReference type="EnsemblBacteria" id="ARF82921">
        <property type="protein sequence ID" value="ARF82921"/>
        <property type="gene ID" value="B6264_18945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35328">
        <property type="protein sequence ID" value="OEV35328"/>
        <property type="gene ID" value="HS99_0033005"/>
    </dbReference>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="1">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="1">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="1">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="37099" checksum="794019BB19FA0930" modified="2017-01-18" version="1">MNVNPANGGTDPAQVVRTWPDLLAALLKGEDLDRSSTAWAMDRIMSGEASPVQVAGFMVALRAKGETVDEIAGLVDAMYEHAEPLDIPGPAVDIVGTGGDRAKTVNISTMSAIVAAAAGAKVVKHGNRAASSSSGSSDVLEKLGVALDLSARRVAEVAEEVGLTFCFAAKFHPSMRHAATARRDLGVPTAFNILGPLTNPAKVTSHAIGCFDTRLAGLIAGVLARRGATALVFRGDDGLDELTITTTSRVWVVRDGVVTETVFDPRDVGIELVGIEALRGADAAYNAEVARRMLAGERGPVRDAVLLNTAAALVAMDLGDAPLAEQLAAGMARAAEAIDSGAAQELLRRWSEATSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y6</accession>
    <name>A0A1E7N3Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285471.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000886.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4479"/>
    <dbReference type="EnsemblBacteria" id="ARF78424">
        <property type="protein sequence ID" value="ARF78424"/>
        <property type="gene ID" value="B6264_05365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35173">
        <property type="protein sequence ID" value="OEV35173"/>
        <property type="gene ID" value="HS99_0033890"/>
    </dbReference>
    <dbReference type="OMA" id="HRIRTTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6800" checksum="DDC58DBE8A94C921" modified="2017-01-18" version="1">MDAFKAGILQRIANAEQDLHRAIEAGDEFLAEVEQSELDDLRRLAAEHGVDTVLDRHRTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N417</accession>
    <name>A0A1E7N417_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0032200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1601"/>
    <dbReference type="EnsemblBacteria" id="OEV35425">
        <property type="protein sequence ID" value="OEV35425"/>
        <property type="gene ID" value="HS99_0032200"/>
    </dbReference>
    <dbReference type="OMA" id="QLNEPGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="31610" checksum="69EE2F055BEFA59A" modified="2017-01-18" version="1">MILTLTLNAALDVTYRVDRLRPRGSNRVRSTAERAGGKGINVARVLHALGRETVVTGFAGGAAGETLRRDLAAARLPERLLPIAGETRRTVAVVDESAGDTTILLEPGPAVPTEDWARLLDHVDRLLTQASAAVFSGSLPPGAPEDAYGRLVRLAHAHRVPAVVDADGAALRAALAAGPDLVKPNADELAAATGLADPVAAAGALVDAGAGAVVASLGPDGLIAVTPQGSWWAMPPEQLAGNPTGAGDAAVAALTLGLVDATPWPERLAEAVALSAAAVAAPLAGDFDPDVHRRLRALVDVQPLHSQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N430</accession>
    <name>A0A1E7N430_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283426.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3875"/>
    <dbReference type="EnsemblBacteria" id="OEV35447">
        <property type="protein sequence ID" value="OEV35447"/>
        <property type="gene ID" value="HS99_0032320"/>
    </dbReference>
    <dbReference type="OMA" id="DLQMRRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20901" checksum="5355198D40C77B61" modified="2017-01-18" version="1">MTDNQPRPSLRVCVIGLAGVGKSTCAGLIEEFARDKGLTYARVKLAEPLYHLQEQVYRTAGADLREDAQDQVLMEALADAMRRIRPESLADDFTRRLARTDAELVVNDDLRDPHVDAPALRAHGFRVLRVVCDEALRQSRLDQRDDPTRADRSTRQIDLIEPDAVIDNGAGLDAYRAAVHELLGSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K3</accession>
    <name>A0A1E7N4K3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000518.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene968"/>
    <dbReference type="EnsemblBacteria" id="ARF80811">
        <property type="protein sequence ID" value="ARF80811"/>
        <property type="gene ID" value="B6264_19555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35615">
        <property type="protein sequence ID" value="OEV35615"/>
        <property type="gene ID" value="HS99_0006785"/>
    </dbReference>
    <dbReference type="OMA" id="RFREHWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="32491" checksum="EAD0AF9F4A4D4122" modified="2017-01-18" version="1">MRAIVQQEFGGPEVMKVAEVERPKPLSGEVLVRVKAAGVNPVDVAVRAGAFPLLGEPPFTVGWDVSGVVEEAGPGARYRVGEEVYGMPFFPRAAGAYAEYVAAPSRQLARKPASLDHTEAAALPLAALTAWQGLVDLAKVGEGDRVLVHRAAGGVGHLAVQIAKARGAYVIALASEPKHTFLKEIGADEVLDYRTTDYTEAVQDVDVVFDSSSEGTRALEVLKPGGTLVSIMEHWNQELAAEIETAGRRFAGVSVEPDYAGLEAIAALVDEGRIRPHVAAVFPLAEAGRAHELVASGTVQGKVVLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4L1</accession>
    <name>A0A1E7N4L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281846.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene949"/>
    <dbReference type="EnsemblBacteria" id="ARF80825">
        <property type="protein sequence ID" value="ARF80825"/>
        <property type="gene ID" value="B6264_19655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35631">
        <property type="protein sequence ID" value="OEV35631"/>
        <property type="gene ID" value="HS99_0006885"/>
    </dbReference>
    <dbReference type="OMA" id="KVVCNIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="43316" checksum="5D9047AE7916956A" modified="2017-01-18" version="1">MRRSRLLLSLALSAVTASALVAADAAPDEPIRSVRLPVLRDPQAQQTLHRMTDPVQDWVESGDQAADGYAGTVIDAWNQHADLYWKGEAPTKVQALLGANASPGFTVDVHRSPYSRAEMRAAIERFTAAVAPGAWTSIGPQEDGAAISITYVPSKATRLTGGATTEQAYSRRAAEIAGMPVTATVEGIPAALSGSRHSDSAPYYAGAEVNTGKAAFCSTAFSGWKDRTKVLLTAAHCGGGRYYNGTGGYIGDLYAIGDGLDVGMIAINGNGADRFYDGAWSDRSGSSRHTYGAGRNNVGDLVCLSGAQSGWKCDVEVKKVDVETTNDEGTRIRPVDIAESKGGDRRAVGAKGDSGGPALANPSGASGDMEARGVIVAGRSEVSCPAGSTAHSTTCYAQVMYVPMTPVVNQMGFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U9</accession>
    <name>A0A1E7N4U9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551070.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene838"/>
    <dbReference type="EnsemblBacteria" id="ARF80923">
        <property type="protein sequence ID" value="ARF80923"/>
        <property type="gene ID" value="B6264_20220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35721">
        <property type="protein sequence ID" value="OEV35721"/>
        <property type="gene ID" value="HS99_0007450"/>
    </dbReference>
    <dbReference type="OMA" id="ASWPGIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24219" checksum="E245FD27B7BE9CCB" modified="2017-01-18" version="1">MTGPTHEATADLITLPGTPLADAVVNLIRPVETPSVFNHSIRSYLFARLVAGRLGLAAGHDYQDDLLFAACAMHDLGLASDGPHSQRFEVEGADRAASFLTDRGVSAADADQVWQAIALHTSSGIAERRGTLCVLVREGVTLDFGGRVGANHVDAVTDEQADAVHAAYPRLDMIRSLTDAIVAQAAKEPKNAPRYTTPGELLRERETFGRTRLEHFYRSSRWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N552</accession>
    <name>A0A1E7N552_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281367.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene716"/>
    <dbReference type="EnsemblBacteria" id="ARF81025">
        <property type="protein sequence ID" value="ARF81025"/>
        <property type="gene ID" value="B6264_20835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35815">
        <property type="protein sequence ID" value="OEV35815"/>
        <property type="gene ID" value="HS99_0008060"/>
    </dbReference>
    <dbReference type="OMA" id="YAMRPLF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="21559" checksum="689BB585B253E4CC" modified="2017-01-18" version="1">MTAFKLAAVSAGLSKPSSTRLLADRLAEATVRRLGEEGREAEVAVIELRDLAVDIANNFVTGFPAAALREAIGTVTEADAVIAVTPIFTASYSGLFKSFFDVIDHDALTGKPVLIAATGGTARHSLALEHAVRPLFSYLRAVVLPTAVYAATDDWGTAGDALTDGLPGRIERAAGELAGLLAGHGPVAEAAVPEQVVPFAEQLAALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Q3</accession>
    <name>A0A1E7N5Q3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6321"/>
    <dbReference type="EnsemblBacteria" id="ARF78798">
        <property type="protein sequence ID" value="ARF78798"/>
        <property type="gene ID" value="B6264_07600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36036">
        <property type="protein sequence ID" value="OEV36036"/>
        <property type="gene ID" value="HS99_0031525"/>
    </dbReference>
    <dbReference type="OMA" id="WHLDVQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="21384" checksum="1F6A44E7BC9C952A" modified="2017-01-18" version="1">MTATGTGTTSTLHADAVRTLTDWRPADQDQEQLRLDYLAHLAEQPEGVYRSCLPAHLTASAAVIDPAAGRVLLTLHPKVGMWLQMGGHCEPGDADLASAALREAVEESGIPDLTLLRENGAPVPAKLDRHQVRCTGKDRPENTHLDVQYIALAPAGAQALISEESLDLRWFDFDRLPELTDHSVRDLVARARRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5S2</accession>
    <name>A0A1E7N5S2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0182 protein HS99_0031560</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551251.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000436.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6328"/>
    <dbReference type="EnsemblBacteria" id="ARF78792">
        <property type="protein sequence ID" value="ARF78792"/>
        <property type="gene ID" value="B6264_07565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36042">
        <property type="protein sequence ID" value="OEV36042"/>
        <property type="gene ID" value="HS99_0031560"/>
    </dbReference>
    <dbReference type="OMA" id="HLRYPQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1007" mass="108316" checksum="8FE423DA0C5CD4ED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V4</accession>
    <name>A0A1E7N5V4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene519"/>
    <dbReference type="EnsemblBacteria" id="ARF82687">
        <property type="protein sequence ID" value="ARF82687"/>
        <property type="gene ID" value="B6264_07625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36065">
        <property type="protein sequence ID" value="OEV36065"/>
        <property type="gene ID" value="HS99_0031500"/>
    </dbReference>
    <dbReference type="OMA" id="THHEQDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="12082" checksum="1985A26F4D91FC20" modified="2017-01-18" version="1">MAAAKADTAASTRPFPSTHHEQDHHMTPAAIDPTVRAEQTTELQIQNRTLEMQLLHESLARAHMQDRLHEAEEQRLVSRVVRARKLRQRAERASMRARKALAVALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G3</accession>
    <name>A0A1E7N6G3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366946.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2639"/>
    <dbReference type="EnsemblBacteria" id="OEV36281">
        <property type="protein sequence ID" value="OEV36281"/>
        <property type="gene ID" value="HS99_0030195"/>
    </dbReference>
    <dbReference type="OMA" id="RSADEEW"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1065" mass="116417" checksum="4B259DB5F9ED6BD8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I6</accession>
    <name>A0A1E7N6I6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386483.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2631"/>
    <dbReference type="EnsemblBacteria" id="OEV36288">
        <property type="protein sequence ID" value="OEV36288"/>
        <property type="gene ID" value="HS99_0030235"/>
    </dbReference>
    <dbReference type="OMA" id="STWLYEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PTHR35802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23381" checksum="62883B0C0B74324D" modified="2017-01-18" version="1">MFTPKLYQVDGDDWPLRIIERHPLAVLVSNGDPVPNATHVPVIAPPDAAPEDALSGMRLWAHLTRANPHWQQLAAAGGGPAKLVFHGPNGYVTPSLYSADMVAPTWNYVAVHLEGTVELAGDDETLAIVHTTAQTLEDRFGDGMALAPSLEYHRQIVGAVGGLFFTVTKVDVMFKLSQEKDPEVQQRVLDRFAASGSGLHREVADTMRALRLGGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q5</accession>
    <name>A0A1E7N6Q5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA_LIGASE_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737887.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7176"/>
    <dbReference type="EnsemblBacteria" id="OEV36358">
        <property type="protein sequence ID" value="OEV36358"/>
        <property type="gene ID" value="HS99_0029820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="2">
        <location>
            <begin position="420"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="608" mass="65125" checksum="53E16BEBF2D61C12" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6S7</accession>
    <name>A0A1E7N6S7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7732"/>
    <dbReference type="EnsemblBacteria" id="ARF82329">
        <property type="protein sequence ID" value="ARF82329"/>
        <property type="gene ID" value="B6264_28730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36379">
        <property type="protein sequence ID" value="OEV36379"/>
        <property type="gene ID" value="HS99_0029935"/>
    </dbReference>
    <dbReference type="OMA" id="AQEAFYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15455" checksum="30CE78F6849BB444" modified="2017-01-18" version="1">MRLTKSTDIALRIAMRLAVLGEGENPTTREVAESVGVPYTHAAKVVSRLQHLGVVEARRGRGGGLMITFAGRTGSLGLLLRELEGIGDVVGCEDEPPCPLRAACRLRGALRTAQEAFFAALDPLSIDDLVASPTGPVLLGLTARPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A9</accession>
    <name>A0A1E7N7A9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0029110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552642.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7917"/>
    <dbReference type="EnsemblBacteria" id="OEV36581">
        <property type="protein sequence ID" value="OEV36581"/>
        <property type="gene ID" value="HS99_0029110"/>
    </dbReference>
    <dbReference type="OMA" id="WYRQWSS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="30276" checksum="A217E150E0F060F4" modified="2017-01-18" version="1">MTAHRLEARGLTLAYEARTVAEGLDVSIPDGRVTVIVGPNACGKSTLLRALGRLLKPVRGAVLLDGQELARIPTKRIAQRLGLLPQSPTAPEGISVADLVSRGRQPHQSWWQQWSPEDEAAVAEALERTSTAELAERSMDELSGGQRQRAWIAMTLAQGTDILLLDEPTTYLDIAHQVEVLDLVRRLNVERGRTVVAVLHDLNQAARYADHLVAMRDGRVVAEGAPGEVVTAELVREVFGLDSVVVPDPVTGTPLVVPGAPWAARADAADAVDAVDAVNAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B3</accession>
    <name>A0A1E7N7B3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552640.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7916"/>
    <dbReference type="EnsemblBacteria" id="ARF79118">
        <property type="protein sequence ID" value="ARF79118"/>
        <property type="gene ID" value="B6264_09480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36580">
        <property type="protein sequence ID" value="OEV36580"/>
        <property type="gene ID" value="HS99_0029105"/>
    </dbReference>
    <dbReference type="OMA" id="RIIMLVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="33948" checksum="1D25CCEA7EC4FD5B" modified="2017-01-18" version="1">MPRIARRTFLAGLGGAALTACTSSSGGSQPPTPDGFEASGSPSPTPLPPVTVNAANGPVLVPGEPQRVVVLDTDVLDSALTLGVTPVGAALPAADTRFPNYWPASRTAGIRLVGPAGAPDLDAVRALRPDLILSNQGRDGDRYEQLRGIAPTVLTQTTGAPWKANFQLHAQALGRVAAAGAFVAAYQKHAGQVVQALSAAKLSGHRVSLVRFVEGGGIRLFGRQSFPGIVLTDAEVGRPDAQNVDQSDFEVPLDQIAKADGDLLLYATYGDPAKAGTDAALASPGWQALGAVKAHRAFPVDDQLWFQGIGYTAANFMLDELQRFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I6</accession>
    <name>A0A1E7N7I6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0029270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene234"/>
    <dbReference type="EnsemblBacteria" id="ARF82261">
        <property type="protein sequence ID" value="ARF82261"/>
        <property type="gene ID" value="B6264_28345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36433">
        <property type="protein sequence ID" value="OEV36433"/>
        <property type="gene ID" value="HS99_0029270"/>
    </dbReference>
    <dbReference type="OMA" id="LYTPNIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="372" mass="40069" checksum="F72D32B29DBE3D1A" modified="2017-01-18" version="1">MPDRSSPDTAPLPLELQLDHVEFYVADLAAELTRLTTEYGFDLLVPPTERGGTAERCVSALVGQAAVRLLLTQPLAAGHPATDYLARHDDGVAALALRVPDATAAYRTLTGRGADGLRPPQAVDGCVTAVVGAFGDVVHTLIERGPDVPADRIPGLPDAAPADQGPTLDADAVGLRSVDHFAVCVPSGELRETVRRYCEVFDFRMIFEERIEVGALGMDSMVVQSPDHSVTLTLIEPLTPDAGGQIASFLADHGGAGVQHVAFSSQDAVHSVATMAARGVPFLRTPAAYFDALPARLTPLRHSLDQLRELNLLVDQDHDGQLFQIFTRSRHPRGTFFFEVIERIRARNFGSNNIRALYEAVELQRNASEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N2</accession>
    <name>A0A1E7N7N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278855.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2496"/>
    <dbReference type="EnsemblBacteria" id="ARF81505">
        <property type="protein sequence ID" value="ARF81505"/>
        <property type="gene ID" value="B6264_23635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36678">
        <property type="protein sequence ID" value="OEV36678"/>
        <property type="gene ID" value="HS99_0028350"/>
    </dbReference>
    <dbReference type="OMA" id="LADWQGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="19933" checksum="3CDBB1F12D94F05B" modified="2017-01-18" version="1">MEYRIERIGREDWQRLRTIRLAQLLDTPMAFGEPYEYARIQGEGNWRARTDWLNEPGRIGLVAVDDTDQWVATMLGTPSVKAETVDLIGVWVDPAHRGRDRGVADALLDAVIAWARDGGARWMLLGVHEANHRAAAFYRRRGFTYTGGETPYVLDEGARILEMRLPLEQARQPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R9</accession>
    <name>A0A1E7N7R9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2489"/>
    <dbReference type="EnsemblBacteria" id="OEV36718">
        <property type="protein sequence ID" value="OEV36718"/>
        <property type="gene ID" value="HS99_0028380"/>
    </dbReference>
    <dbReference type="OMA" id="RIHANEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="301"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="41449" checksum="A9367BF0574E59FB" modified="2017-01-18" version="1">MRVDPVQADTALAVVLTVVTIVYGLQSYQARYRAEGWRPFDLAAAGLCVLVALPLAVRRRHPWPVLVLSVTGLLVYTGAGFQPSVNVWPPLLAGYTVIARQPPREAVAAGTLTGGAWIASGLEARLSVELAVAQSVIALGIVGIFATGTRRLAERNAQLAEATDRLRREQELRARHAVVEERVRIARELHDVIAHHLSALAVQAGVAEYVFASDPPAARAALAAIGATSREALEEMRGLLQVLRVSGEVPCDQERLYRAAPGLAQLGELVERTRAAGVPVRVVVAGSARMLAPGVDLCAFRVVQEALTNVIKHAGRPATATVDLCYRPDRLEGRITDDGPGNGRAVPGSGLGLIGIRERVRLYGGSVHTGPRPDGGFEVAFTLPVTSTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X0</accession>
    <name>A0A1E7N7X0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386624.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000433.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4750"/>
    <dbReference type="EnsemblBacteria" id="OEV36734">
        <property type="protein sequence ID" value="OEV36734"/>
        <property type="gene ID" value="HS99_0027305"/>
    </dbReference>
    <dbReference type="OMA" id="HITMPYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23252" checksum="AE8C9569A4E848A3" modified="2017-01-18" version="1">MKSVQQEQGAGWIREQIAAERRELAGVFAGLTAEQWNSPSLCEGWRVREVVAHMGTGFRHSTARTLGELVRSGGNVHRMADRIARRDAAALTEDRLAAALAEHAEHPWRPPVGGRIAALAHDAVHGLDVTVALGLRARLPLPRAAALLGTVSARSLRFFGARLEGVRLRATDLDWSYGQGPLPVEGRAEHLLLVAYGRRVPAGLLSGAGAERFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N882</accession>
    <name>A0A1E7N882_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36905">
        <property type="protein sequence ID" value="OEV36905"/>
        <property type="gene ID" value="HS99_0026960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6397" checksum="99C5480F1C510E31" modified="2017-01-18" version="1">MISQREVISCACGLDLVVVARFRAAVVLRLSWARTCTVAEPGPGVGSVSTAMSTLPSLAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8P9</accession>
    <name>A0A1E7N8P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81669">
        <property type="protein sequence ID" value="ARF81669"/>
        <property type="gene ID" value="B6264_24660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37061">
        <property type="protein sequence ID" value="OEV37061"/>
        <property type="gene ID" value="HS99_0004335"/>
    </dbReference>
    <dbReference type="OMA" id="FEYWARE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17084" checksum="2893B00F29C82DA3" modified="2017-01-18" version="1">MSATAAPAAAPTESASAVLNVPAAAPAEAAAHYAARLAFEADVSDVHADLESGAPGIVVVDTRGEAAWEQGRIPGALHIPTARIAELAPQLVDPSLTVVTYCWGPGCNGATRGALAFARLGYRVKEMLGGFEYWAREGFAYETAAGTDQRPVDDLTAPRSGITCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N974</accession>
    <name>A0A1E7N974_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555229.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37241">
        <property type="protein sequence ID" value="OEV37241"/>
        <property type="gene ID" value="HS99_0005415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="10446" checksum="E5D699ED48197A0F" modified="2017-01-18" version="1">MDEEAICWAAGAEVPSRWAELIEDVYDRSHSTWGVDFGHHHGMTWTLPPLEPGDHCELPVVAAAWAPVTDETANTWYAVLASSTDLLRQATDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N983</accession>
    <name>A0A1E7N983_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37256">
        <property type="protein sequence ID" value="OEV37256"/>
        <property type="gene ID" value="HS99_0005505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9766" checksum="D819D6A4400D1895" modified="2017-01-18" version="1">MRAVILSMPNSPQAQDERAQHFRRRMHSIEQIRQRATARGESPPPLEQILDQLVAPFYLRAIFGIDPPATGYPEVLVDRLLGTTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E1</accession>
    <name>A0A1E7N9E1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366189.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1242"/>
    <dbReference type="EnsemblBacteria" id="OEV37312">
        <property type="protein sequence ID" value="OEV37312"/>
        <property type="gene ID" value="HS99_0005855"/>
    </dbReference>
    <dbReference type="OMA" id="NIERQPI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="706" mass="76344" checksum="C502E221528410CA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F0</accession>
    <name>A0A1E7N9F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558372.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000117_gene4550"/>
    <dbReference type="EnsemblBacteria" id="OEV37316">
        <property type="protein sequence ID" value="OEV37316"/>
        <property type="gene ID" value="HS99_0005880"/>
    </dbReference>
    <dbReference type="OMA" id="AWYERWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="38711" checksum="A015E8E056D4620D" modified="2017-01-18" version="1">MGHDGAGPHYGLLPLTDWNVDGSTATGHLARPFPVEPAVRVGQDWWQRLGRPRPPFSGTMAITSQGCSYLTALVVTGPARGRVVNIDLDPERELFFSPDTDFLAWYERWLDETADGLDTGGFSLSIPGTEPTLADTLTTSPDPELRIAAARTLRRRPYLAPTTRAVLRAAVASDPEPVVRASAITTLNVAPTDEDLRVLYQALADPAPAVREAAVRTLARRGTFWQAKARWLLRDEDPEVKKAALKALEDSQVLTEEDVLPLRDDSAASVRAAVISHLSPLDAPSAPATTRAALADPDSLPRVTAVAIGIRRRWLTETDLRAVEHDLDDQIRKRVTSALTRMTRRSAGSASPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R4</accession>
    <name>A0A1E7N9R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555270.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37223">
        <property type="protein sequence ID" value="OEV37223"/>
        <property type="gene ID" value="HS99_0005315"/>
    </dbReference>
    <dbReference type="OMA" id="DPPRIYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10640" checksum="533CD5E82A91F2DA" modified="2017-01-18" version="1">MSDFSDVPDDEHDPITLSPVVEEFLGDPDTPADVFSAVVAFLIDLRQNAFPHLSLPVPGRPGMHSAPLRRDQGLVEYAVNEGSDPPQIYVSRILRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA26</accession>
    <name>A0A1E7NA26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286506.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1141"/>
    <dbReference type="EnsemblBacteria" id="ARF79021">
        <property type="protein sequence ID" value="ARF79021"/>
        <property type="gene ID" value="B6264_08905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37550">
        <property type="protein sequence ID" value="OEV37550"/>
        <property type="gene ID" value="HS99_0026450"/>
    </dbReference>
    <dbReference type="OMA" id="GPGLMAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27101" checksum="368A285BCD6FB3AF" modified="2017-01-18" version="1">MATDRSSAGDPARTLALLWGLTAEEKPGRRGPKQARSTGEIAATAIALADAEGVDAVTMRRVAQELGLSPMALYTYVPGKAELLDLMLDTVYATMPRTAPADDGWRARATAVADDNRALFRAHPWVAAVSTSRPPLGPGLMAKYEYELSALEGTGLPDVELDAALTHLLGFVQTCARMAADERAAQQDSALTDAQWWQANADLLARVFDPERYPVAARVGAAAGEAHGGAYSPDHAYAFGLARVLDGLAALIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAE3</accession>
    <name>A0A1E7NAE3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="9" type="ORF">HS99_0025495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030055803.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1695"/>
    <dbReference type="EnsemblBacteria" id="ARF79916">
        <property type="protein sequence ID" value="ARF79916"/>
        <property type="gene ID" value="B6264_14285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37659">
        <property type="protein sequence ID" value="OEV37659"/>
        <property type="gene ID" value="HS99_0025495"/>
    </dbReference>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="17431" checksum="CA8373693DE78139" modified="2017-01-18" version="1">MPRKGPAPKRPVIIDPVYGSPVVTQLVNKILLHGKRSTAERIVYGALEGVREKTGSDPVVTLKRALENVKPALEVKSRRVGGATYQVPVEVRPGRASTLALRWMVGYSRARREKTMTERLMNEILDASNGLGASVKRREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB89</accession>
    <name>A0A1E7NB89_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase HS99_0023960</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552091.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2088"/>
    <dbReference type="EnsemblBacteria" id="ARF79480">
        <property type="protein sequence ID" value="ARF79480"/>
        <property type="gene ID" value="B6264_11630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37928">
        <property type="protein sequence ID" value="OEV37928"/>
        <property type="gene ID" value="HS99_0023960"/>
    </dbReference>
    <dbReference type="OMA" id="DWLWVRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="44357" checksum="9C39C6A225AAD2EA" modified="2017-01-18" version="1">MDIRSTTDQDLDVFVDTLHTAFGRFPETPAEDGGGVWWSAVEPDRGVLAVAEDGRPVGTAAAYSFELTLPGGAVVPVSGVSNVGVLPTHRRRGVLTAMMRHQLAGLRARGEFLSVLLASEAPIYGRFGYGPATYTGNLKVARTGAALDLPRARGTAADAPDRGTVEVLRRADCGDLLEELYDRYRRAQPGALSRPPRWWALGAGQPPVSRAPRYVAVHRDADGHPDGYATYTVDGETLKVDETITVDDAVTTALVRFLLAHDLVTQVLFKHFPPGHPLRWQLVDFRAAEASYDTDWLWVRLLDVPQALTARGWSADGELVLDVDDPFLGERARHLLTVRDGKAECVPTDREPDLSLDVRDLGSVYLGGTAPSTLVRAGHVRAHRPEAAALADALFRAERAPHCLHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBG8</accession>
    <name>A0A1E7NBG8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8138"/>
    <dbReference type="EnsemblBacteria" id="OEV38031">
        <property type="protein sequence ID" value="OEV38031"/>
        <property type="gene ID" value="HS99_0022750"/>
    </dbReference>
    <dbReference type="OMA" id="CHRVVAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="83"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19076" checksum="0DE16FC54B002FB5" modified="2017-01-18" version="1">MPQSWSLSWLTVPTPLPSGPMHIAVTPLGVAAAGYGGRDGETPPCTDPAKVTAVTERIGAYLAGRTRELGLPIDWSLSSGPHRTVLRTLREQVPYGRTITYGELAARSGVFEDVTEPGLAARTVGQMMAANPVALLVPCHRVVAADGIGGFGGGRVGIDVKRWLLTLEGVLEPTLDWNGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ7</accession>
    <name>A0A1E7NBJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387329.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000825.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3037"/>
    <dbReference type="EnsemblBacteria" id="ARF79727">
        <property type="protein sequence ID" value="ARF79727"/>
        <property type="gene ID" value="B6264_13165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38062">
        <property type="protein sequence ID" value="OEV38062"/>
        <property type="gene ID" value="HS99_0022935"/>
    </dbReference>
    <dbReference type="OMA" id="WALVDCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12559" checksum="8736761972E6DA7B" modified="2017-01-18" version="1">MTGVFQILAFSYLNPFWWMAVAILGYKFFALVDAATRREDAYRAADKKTKGFWLAVLGISFGWDLLFGANFLGSIGTLAGLVASIVYVVDVRPAIRALTGGSGRGGRSNTGPYGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX6</accession>
    <name>A0A1E7NBX6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288187.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1907"/>
    <dbReference type="EnsemblBacteria" id="ARF79631">
        <property type="protein sequence ID" value="ARF79631"/>
        <property type="gene ID" value="B6264_12585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38158">
        <property type="protein sequence ID" value="OEV38158"/>
        <property type="gene ID" value="HS99_0023500"/>
    </dbReference>
    <dbReference type="OMA" id="TPRWWGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27883" checksum="14519E2DB6463080" modified="2017-01-18" version="1">MYRFLLTPRWLGGTALAMAAVVVCVWLGSWQLGRFEDRVSTHQDTKASLTASGDARPIDALLGQATPQVTTETVGKPVTVTGSFDAEHQLLVPNRVLDGKQGYYVLTPLRTADGHAVAVVRGWAPGAPSGSASAAEAAPAGQVTVTGRLQANESVGSNGAVAGGLPAGQLGMINRASLLNVLEYDGWYDGWVAADQVPAGLTAVPTVQPQGGDGLTLRAFQNLGYTLEWFVFAGFVIFMWFRLMRREAEAEQDRALGLDPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC74</accession>
    <name>A0A1E7NC74_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284069.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4186"/>
    <dbReference type="EnsemblBacteria" id="ARF80190">
        <property type="protein sequence ID" value="ARF80190"/>
        <property type="gene ID" value="B6264_15855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38292">
        <property type="protein sequence ID" value="OEV38292"/>
        <property type="gene ID" value="HS99_0022415"/>
    </dbReference>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="46311" checksum="67C595B5AC97153A" modified="2017-01-18" version="1">MDATSVRAAGSTALLTDRYELTMLQAALRSGAAHRRSVFEVFTRRLPSGRRYGVMAGTGRVLDAVENFRFETPQLDWLSDQGVVDDDTLRFLADYRFRGDIHGYPEGEVYFPGSPVLTVEGSFAETVILETVILSILNFDSAVAAAASRMTAAAGGRPVIELGARRAHEQAAVAAARASYVAGFAATSDLEAGYLHGIPTTGTSAHAFTLVHDSERDAFRAQIESMGRGTTLLIDTFDLREAVRTAVEVAGPELGAVRIDSGDLILAAHRVRRQLDELGAGKTRIIVTSDLDEYAIAALAAAPVDGYGVGTSLVTGSGHPTCAMVYKLVARAETQDGPLVPVAKRAAGGKTSIGGRKWAARRPDAEGVAEAEVIGTGPVPDELRPHLTQVPLVLAGEAVGREPLTAARERHIRARAALPLSATQLSKGDPVIPTELIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC77</accession>
    <name>A0A1E7NC77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553268.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4172"/>
    <dbReference type="EnsemblBacteria" id="ARF80176">
        <property type="protein sequence ID" value="ARF80176"/>
        <property type="gene ID" value="B6264_15780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38306">
        <property type="protein sequence ID" value="OEV38306"/>
        <property type="gene ID" value="HS99_0022490"/>
    </dbReference>
    <dbReference type="OMA" id="FFDKPYK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26383" checksum="EB17582D146C2E4D" modified="2017-01-18" version="1">MSTHDPSGPQPEGGGQPSSDKQPPAPGGGTPEGEPPRPTPSDEPYGGPTGASTGAPSGPPPGAPSEGPGAYQGNYGGPTHGQNPYGQPPYDQPPPGYGPGPGMYGAPSGGPVPGMPPIGTWPKRILARVIDYVLVQVVGVIVVSPFVDLGTRQGSTEAFWLGCVIYLVYEALMLARDGQTLGKKAMKIRVAMLVDGNTPTQAAAWTRAAVYILPAVICCAALWWIIDGLFGVFDKPYRQCVHDKAAKTVVVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC80</accession>
    <name>A0A1E7NC80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291135.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000326.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1729"/>
    <dbReference type="EnsemblBacteria" id="ARF80218">
        <property type="protein sequence ID" value="ARF80218"/>
        <property type="gene ID" value="B6264_16025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38264">
        <property type="protein sequence ID" value="OEV38264"/>
        <property type="gene ID" value="HS99_0022245"/>
    </dbReference>
    <dbReference type="OMA" id="HRMNEVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33047" checksum="626AA4D40B4EB31B" modified="2017-01-18" version="1">MAAISAVGLTKSYGDKAVLRGIDLSIPAGTVFALLGPNGAGKTTTVEILSTLIPADAGSVQVAGHDLVREADGVRRAIGVTGQFSAVDNLLTAEENLMLMADLNHLRRREGRRRAEELLRRFDLTDAARKPVVTFSGGMRRKLDLAMTLVGDPKVIFLDEPTTGLDPRSRRTMWEIIRGLVADHGVTIFLTTQYLEEADQLADRIAVLDGGRIVAEGTAEELKRIVPGGRIRLQFTDAGQLDTAAALFDYATADAEALRLDIPGDNSVITVKAVLDTLDNASVRAESLVVETADLDDVFLQLTGEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ3</accession>
    <name>A0A1E7NCJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554483.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene278"/>
    <dbReference type="EnsemblBacteria" id="ARF82198">
        <property type="protein sequence ID" value="ARF82198"/>
        <property type="gene ID" value="B6264_27945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38412">
        <property type="protein sequence ID" value="OEV38412"/>
        <property type="gene ID" value="HS99_0021110"/>
    </dbReference>
    <dbReference type="OMA" id="QVGPYQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="44188" checksum="BF8C754CE1B81E99" modified="2017-01-18" version="1">MTAPDFEDLLRDLTPQVLGTLVRRHGRFEGCEDAVQEAVLAASVQWPEEGVPDNPRGWLVTVAARRLVDQIRRDHARRERETATTAAEVVPEEVPDTDDTLLLLFLCCHPSLTAASQTALTLRAVGGLTTAEIARAFLVPEATMAARISRAKQRIRAAGSSFALPEGAEREERLRVVLHVLYLIFNEGYTASSGSELHRADLAQEAIRLARMVHAQLPEDGEVTGLLSLMLLTHARRAARTTAAGDLVPLAEQDRSTWERDLLDEGTALAKAALAGPELGPYQLQAAIAATHADAATAEETDWAQVHALYLILERIAPNPMVTLNRAVALAERDGPKAGLALLATLDGDQRMAGHHRLLSVRAHLLERSGDRAGAYDHYRRAAKATASLAEQRFLEARARRLRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCK4</accession>
    <name>A0A1E7NCK4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3305"/>
    <dbReference type="EnsemblBacteria" id="ARF80277">
        <property type="protein sequence ID" value="ARF80277"/>
        <property type="gene ID" value="B6264_16385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38213">
        <property type="protein sequence ID" value="OEV38213"/>
        <property type="gene ID" value="HS99_0021895"/>
    </dbReference>
    <dbReference type="OMA" id="MPWEVAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="31181" checksum="29D77516CB18A643" modified="2017-01-18" version="1">MKAVTVPGPGGPEALRVTEVPDPEPGAGEVRVRVYAAGVQPVDLAIREGFRPPGMTAEPPFVLGNEFAGVVDRLGPGVDGRRVGDQVLGFRLLGCQAELVAVDAAQLVAKPAGMPWEQAGALSASGQTAHLALTLLGVGPGDTVLVHGAAGGVGTVAVQLARAWGATVIGTASERNHDYLRELGAVPVTYGEGLVERVRAVAPQGVDAAFDAAGRGALAASVELVADRDRIGTVVDYPEAERLGVRGLRGPRTAERLAELVRLWEAGGLRLEIAETLPLEKAEEAHRLVATGHVRGKVVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCL0</accession>
    <name>A0A1E7NCL0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000276.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene297"/>
    <dbReference type="EnsemblBacteria" id="ARF82179">
        <property type="protein sequence ID" value="ARF82179"/>
        <property type="gene ID" value="B6264_27845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38430">
        <property type="protein sequence ID" value="OEV38430"/>
        <property type="gene ID" value="HS99_0021210"/>
    </dbReference>
    <dbReference type="OMA" id="NLVVFAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="23665" checksum="DFFBEBA966437227" modified="2017-01-18" version="1">MTRLLRGGMATAAAGLLLIYNAVDTGPGPGSIAGKAAPPTAVAPAVPVPSATAAKPAAPTARPAAPAAIPGAPALKRSKPTRLRIPQIGVEAPFTELTLNPAGQLNPPPPDNKNLVGWYRDGVTPGERGSAVVAGHVDTTKGPAVFLLLSLLVPGNKVEVSREDGTVAVFNVDSVQTFAKDAFPDQKVYGKTPDAQLRLITCGGAYDKKRRDYLDNVVVFAHLESSHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU9</accession>
    <name>A0A1E7NCU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830789.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3102"/>
    <dbReference type="EnsemblBacteria" id="ARF82096">
        <property type="protein sequence ID" value="ARF82096"/>
        <property type="gene ID" value="B6264_27340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38507">
        <property type="protein sequence ID" value="OEV38507"/>
        <property type="gene ID" value="HS99_0021705"/>
    </dbReference>
    <dbReference type="OMA" id="LPDVWWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27926" checksum="D634C544E1D58D83" modified="2017-01-18" version="1">MTTSPTVPETAERTRRLLGVELLIVLGLSLGASGISALISFAGSLTEPLRLGQQVATLNGSRAPGRPWLDLVWQLYYIGRGLMPVVLVGYLLVREGASLRVLGFDLRDKLRDLGRGAGVAAAIGGSGLALYLASQAAGYNLTVAPSGLPDVWWRVPVLVLSAWQNAVLEEVVVLGYLLRRLAQQGWSWPAAVAASSVLRGSYHLYQGVGGLVGNMVMGAVFCLLYRRWGRVMPLVAAHALIDTVAFVGYALLAGHVSWLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY1</accession>
    <name>A0A1E7NCY1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030062488.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3116"/>
    <dbReference type="EnsemblBacteria" id="ARF82086">
        <property type="protein sequence ID" value="ARF82086"/>
        <property type="gene ID" value="B6264_27270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38518">
        <property type="protein sequence ID" value="OEV38518"/>
        <property type="gene ID" value="HS99_0021775"/>
    </dbReference>
    <dbReference type="OMA" id="TGFFFNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="11430" checksum="D44E20CA0F5024E2" modified="2017-01-18" version="1">MIAVLGLVIGVVVGLFVQPEVPDAVVPYLPIAVVAALDAVFGGVRAMLDGIFNDKVFIVSFLSNVVVAALIVFLGDQLGVGSQLSTGVVVVLGIRIFSNAAAIRRHVFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND03</accession>
    <name>A0A1E7ND03_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Squalene synthase HpnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene647"/>
    <dbReference type="EnsemblBacteria" id="ARF77611">
        <property type="protein sequence ID" value="ARF77611"/>
        <property type="gene ID" value="B6264_00565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38586">
        <property type="protein sequence ID" value="OEV38586"/>
        <property type="gene ID" value="HS99_0020150"/>
    </dbReference>
    <dbReference type="OMA" id="DYCRYSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017827">
        <property type="entry name" value="HSQ_synthase_HpnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480:SF17">
        <property type="entry name" value="PTHR31480:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03464">
        <property type="entry name" value="HpnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="34958" checksum="0AC5DC4BAFE6F467" modified="2017-01-18" version="1">MSASAQPRDTPVNPSAGQTLEKAGAENFPVAPFFLPAAWRDDLMAVYGFARLVDDAGDGDLADPAATAALLGVERRPAATPSAQSGRPSPAEAAFRLALLDGLERDLDRVFETALHSADAERPRHPLMTALVPLVDRHQLTPEPFRRLIEANRVDQTTTRYATYDDLVGYCTLSADPVGRLVLAIAGVSTPERIALSDAICTALQVVEHLQDVAEDLSRGRIYLPTEDLERFGVTEEELAAPRATGAVRELIAFEAERARTLLDRGAPLVGTVRGRLRLLLAGFTAGGYAALAAVEDAGYDVLARQAKPDKRRLAVKAAAIFAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND27</accession>
    <name>A0A1E7ND27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6A reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281210.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene628"/>
    <dbReference type="EnsemblBacteria" id="ARF77627">
        <property type="protein sequence ID" value="ARF77627"/>
        <property type="gene ID" value="B6264_00670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38600">
        <property type="protein sequence ID" value="OEV38600"/>
        <property type="gene ID" value="HS99_0020255"/>
    </dbReference>
    <dbReference type="OMA" id="THPYAAQ"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="25593" checksum="C2CE828CDDEBB886" modified="2017-01-18" version="1">MTGAPAHVLVLGGTTEGRALAAALDGRPSLRVTSSLAGRVARPRLPAGQVRVGGFGGPDGLAAWLRAEGVAAVVDATHPFAAGMSRNAALAAAATGVPLLVLRRPGFASVPGDRWHPVPSLPAAAELLPGLGRRVFLSSGRQGIGAFAHLDGLHFLARSVDPPEPPLPPSLEVLLDRGPFTLDGERALLRDHRIDVVVTKDSGGAATAPKLTAARELGLPVVVVERPPVPEGVPVAADVAGAVHWLERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND68</accession>
    <name>A0A1E7ND68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000277.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77674">
        <property type="protein sequence ID" value="ARF77674"/>
        <property type="gene ID" value="B6264_00950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38642">
        <property type="protein sequence ID" value="OEV38642"/>
        <property type="gene ID" value="HS99_0020535"/>
    </dbReference>
    <dbReference type="OMA" id="YQEPRFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6198" checksum="C6A39FE9B5F8212D" modified="2017-01-18" version="1">MNASTQAPYQEPRFPLPQRHRRLLACTAVLASIALGTLGVGATVETVQHGPLATATASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC4</accession>
    <name>A0A1E7NDC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000496.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1804"/>
    <dbReference type="EnsemblBacteria" id="ARF77717">
        <property type="protein sequence ID" value="ARF77717"/>
        <property type="gene ID" value="B6264_01170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38681">
        <property type="protein sequence ID" value="OEV38681"/>
        <property type="gene ID" value="HS99_0020755"/>
    </dbReference>
    <dbReference type="OMA" id="FSSISYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="25914" checksum="3E3091209504511D" modified="2017-01-18" version="1">MERFSGRNVLITGGGSGIGQATVHRILAEGGTVVAVDVNEDGLKRTLDRATADGTADRLTVQVLDIADEAAVVTGMAEAVAALGGLDVLVNAAGILRSSHTHETTLEFWNELLAVNLTGTFLMTREALPALLATGRGVVVNFSSTSAAFAHPYMAAYAATKGGIQSFTHAIASEYSKQGLRAVCVAPGSIDSGMTNNPGLPADADFSLLAKLSPALGQGFAGPETVAGVIAMLASDDGAFVTGTELRIDGGTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG8</accession>
    <name>A0A1E7NDG8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737792.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000565.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1822"/>
    <dbReference type="EnsemblBacteria" id="OEV38694">
        <property type="protein sequence ID" value="OEV38694"/>
        <property type="gene ID" value="HS99_0020850"/>
    </dbReference>
    <dbReference type="OMA" id="ANGGHEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="22346" checksum="977725EBB0A74AE8" modified="2017-01-18" version="1">MGRIEFTAEIAELLGKVRRRPTAGWPWRPGEQVPDGLPTKQSWGWLFAPDGRVLTLVNPRDGICSLPGGSLEPEDAADPAAALAREASEEAQAVIGRPYYLGYLYDRVGSANGGHECARVRMAAALRAVGPSEADPASGRHYRRLLVAPGLAVELLGWGAPGLRQARAAVAAAVHWLGVPAAANETIEELPVEGCTVFPGPVYPGGGRSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDM0</accession>
    <name>A0A1E7NDM0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="9" type="ORF">HS99_0019020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030056230.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000458.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7355"/>
    <dbReference type="EnsemblBacteria" id="ARF81173">
        <property type="protein sequence ID" value="ARF81173"/>
        <property type="gene ID" value="B6264_21750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38765">
        <property type="protein sequence ID" value="OEV38765"/>
        <property type="gene ID" value="HS99_0019020"/>
    </dbReference>
    <dbReference type="OMA" id="PVICDEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="23210" checksum="137953AD09120135" modified="2017-01-18" version="1">MANQKRPKVKIARALGVPLTPKSVKYFEARPYPPGQHGRGRKQNSDYKVRLLEKQRLRAQYDLSEKQMARAFDRAKKAEGKTGEALVADLETRLDSLVLRSGIARTIYQARQMVVHGHIEVNGGKVNKPSFQMKPGYVVTVRERSKEKVPFQVAREGGYAGEGQTPKYLEVNLKALAFRLDRAPQRKEVPVICDEQLVVEYYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT4</accession>
    <name>A0A1E7NDT4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbon monoxide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000247.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1773"/>
    <dbReference type="EnsemblBacteria" id="ARF77686">
        <property type="protein sequence ID" value="ARF77686"/>
        <property type="gene ID" value="B6264_01015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38653">
        <property type="protein sequence ID" value="OEV38653"/>
        <property type="gene ID" value="HS99_0020600"/>
    </dbReference>
    <dbReference type="OMA" id="MVEINFD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="31362" checksum="A504B1EBFCF0E738" modified="2017-01-18" version="1">MEFLRPATWDEALAAKAEYPTALPIAGGTDVMVELNFDVHRPSAILDLNRVTELTEWTNDGSVVRLGASVPYARIISELSGPLPGLALAAHTVGSPQIRNRGGVGGNLGAASPAGDSHPALLAAGRDVHVEAASVRGTRLIPIDEFYVGVKRNCLEADELIRAVHVPVADGPQQFSKIGTRNAMVIAVCAFGFALHPKNGTVGTGIGSAAPTPRRAVEAEEYLQGVLAERGLWESGELLGTEVVQRFGELVKAAASPIDDVRGTADYRRHALAVMARRTLTWCWNDYGKQIRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ7</accession>
    <name>A0A1E7NDZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556356.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5139"/>
    <dbReference type="EnsemblBacteria" id="ARF81261">
        <property type="protein sequence ID" value="ARF81261"/>
        <property type="gene ID" value="B6264_22270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38858">
        <property type="protein sequence ID" value="OEV38858"/>
        <property type="gene ID" value="HS99_0019535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="34821" checksum="04F1116AB17B343E" modified="2017-01-18" version="1">MSLTLFLNELSCESESGPREVDTAMAGFVDTLRHLKSWQSIALVTKSPLPAAELARGYLYQQWVNASGQNRDRHRYLLALRSRSPFRDAVQLTLDPDEVEYQHDGRTVEGVAFAHLTDGLAVSLPVSAKWATAWLDVDIQHLTEDGIESSRDRARHCSSPDEADAHKAWAHEAGTTSLTTPAEILDAWDEFFPHLQKIPRFERCLRRLDMKWHRPVRKLLIDLEATAAGWDPATSPEPKWQHPHITPESQSRQHLCTFTDLDGENRCFSWHGRFTPGKGRLHFRLVPEERAIRLGYVGDKLGSDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE18</accession>
    <name>A0A1E7NE18_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558261.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000919.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38939">
        <property type="protein sequence ID" value="OEV38939"/>
        <property type="gene ID" value="HS99_0017640"/>
    </dbReference>
    <dbReference type="OMA" id="YLHAGST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14816" checksum="2DF127D414EF2E4D" modified="2017-01-18" version="1">MIFDSFPIVGSFRELEYGSPDGPSIRAAVRTAAPEHEGDLVRYLRAGTTLVATPSAVPDVLSESGAFIGGLHLLTDGHWLWYSDLAHYVGRYHVELDPAFIEHARSNNWSIPQISDEHLETMVTLLIGDENEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEK0</accession>
    <name>A0A1E7NEK0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737778.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83304">
        <property type="protein sequence ID" value="ARF83304"/>
        <property type="gene ID" value="B6264_30700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39068">
        <property type="protein sequence ID" value="OEV39068"/>
        <property type="gene ID" value="HS99_0018410"/>
    </dbReference>
    <dbReference type="OMA" id="HARTERT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="17601" checksum="19CD4314A84A7B7B" modified="2017-01-18" version="1">MPSVLGVLERRERVALARAEELRAELEGLQAAVAEADEAARRAVIAREETVAALGELADEAAVPGAPVGAPVVEPVAGVVGPRVEVPFWSEGLGIDALPPDCARIVALVERDAAGGGDGVRARAMREDLGWPASDAREQAARFRAKRLAERGWLSEGRPGLFRPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NES0</accession>
    <name>A0A1E7NES0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557360.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4357"/>
    <dbReference type="EnsemblBacteria" id="ARF83376">
        <property type="protein sequence ID" value="ARF83376"/>
        <property type="gene ID" value="B6264_30230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39138">
        <property type="protein sequence ID" value="OEV39138"/>
        <property type="gene ID" value="HS99_0017960"/>
    </dbReference>
    <dbReference type="OMA" id="TIYNADM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="19886" checksum="43C3BDB8E56FC9ED" modified="2017-01-18" version="1">MDPRTTALIVIDVQQGFINAHSAGAVPVIVRMVEAWKSAGAPVVFARFQNLPNSPYEKISGWTRLRTPEEQAIVAELQPHIGDAAAVVDKGTSSVFANGAGRALAEAGWTDLVFVGIDTDSCVYDSAIDAYHSGFRPWIAVDACASSGGDEYHSAALLLARRNIGSAQLITSHDAIARLTSTERAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NET7</accession>
    <name>A0A1E7NET7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285074.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3464"/>
    <dbReference type="EnsemblBacteria" id="OEV39158">
        <property type="protein sequence ID" value="OEV39158"/>
        <property type="gene ID" value="HS99_0000020"/>
    </dbReference>
    <dbReference type="OMA" id="QHGFWSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="25920" checksum="8BFE477E720EB346" modified="2017-01-18" version="1">MTTATRTARHPSTLATLWRSTVGKKAVMAVTGLVMLLYLVAHMLGNLKVFFGPDDINGYAAWLRTIGQPFLGHEWFLWIARLALLASVVLHGVSAYQLSRRDLAARPSKYVHQRRRASYATRTMRWGGVILGLFVVWHILDLTTLTVNPVAEHGHVYQNIVGTFGRWYSDVIYIVAMLALGFHIRHGFWSAAQTLGANNARRDRALKLTANGLALLLTAGFLSVPVAVMTGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV3</accession>
    <name>A0A1E7NEV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3549"/>
    <dbReference type="EnsemblBacteria" id="OEV39229">
        <property type="protein sequence ID" value="OEV39229"/>
        <property type="gene ID" value="HS99_0000430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="8286" checksum="6B2183E34F57DD4C" modified="2017-01-18" version="1">MTASATEPQRSARWMPSTKAPSTACRTGPGSVWACSPYIDSPPRPTAQSRRPSTISGRGPVLCVLYASFGTAFGLDIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF30</accession>
    <name>A0A1E7NF30_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TetR_C_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366996.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39235">
        <property type="protein sequence ID" value="OEV39235"/>
        <property type="gene ID" value="HS99_0000470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TetR_C_1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14347" checksum="E9C511B4C98FC350" modified="2017-01-18" version="1">MLLDHPAVLTVLATRPAAAPATLTLIERGITVLREDGVPLADALAVLNPVVMWTLGRTLSEVGETPHHEGTEPRPEQLSALDRTTCPHLARAFGTGEGLDSERRFHRTLRNLLAGYAAESDVTEGAGNRPANAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF86</accession>
    <name>A0A1E7NF86_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0000920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387043.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3649"/>
    <dbReference type="EnsemblBacteria" id="OEV39308">
        <property type="protein sequence ID" value="OEV39308"/>
        <property type="gene ID" value="HS99_0000920"/>
    </dbReference>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="12">
        <location>
            <begin position="220"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="784" mass="82491" checksum="E516C1B93B79731A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH7</accession>
    <name>A0A1E7NFH7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5113"/>
    <dbReference type="EnsemblBacteria" id="OEV39461">
        <property type="protein sequence ID" value="OEV39461"/>
        <property type="gene ID" value="HS99_0001815"/>
    </dbReference>
    <dbReference type="OMA" id="HYAAGMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199086" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="18424" checksum="8DA819E0F399A8C8" modified="2017-01-18" version="1">MLGIATTVLLATGAFRSTAPATWRAPGARCGAPALPGQVVDVTTVDMGPGVMAGPNARTPMSGGPGWYGMRLMRLAGHPDTVAAGVVSLRVFNTGALTHEVVVLPLSAGQSAGERPAGPSGRVDEAGSLGEVSRSCAAGAGDGITSGATGWTTVTLQPGRYELVCNFPGHYTAGMYTELDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFQ7</accession>
    <name>A0A1E7NFQ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0002315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481138.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6758"/>
    <dbReference type="EnsemblBacteria" id="OEV39540">
        <property type="protein sequence ID" value="OEV39540"/>
        <property type="gene ID" value="HS99_0002315"/>
    </dbReference>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="216"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV39540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="575" mass="60215" checksum="BEE504E67408675B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT6</accession>
    <name>A0A1E7NFT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285845.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5068"/>
    <dbReference type="EnsemblBacteria" id="OEV39495">
        <property type="protein sequence ID" value="OEV39495"/>
        <property type="gene ID" value="HS99_0002035"/>
    </dbReference>
    <dbReference type="OMA" id="CTITRLY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031221">
        <property type="term" value="P:arabinan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="PTHR39447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199108" evidence="2">
        <location>
            <begin position="38"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ArabFuran-catal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="AbfB" evidence="3">
        <location>
            <begin position="373"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="520" mass="53263" checksum="CEB07B43B89AC34B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV7</accession>
    <name>A0A1E7NFV7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288810.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39383">
        <property type="protein sequence ID" value="OEV39383"/>
        <property type="gene ID" value="HS99_0001375"/>
    </dbReference>
    <dbReference type="OMA" id="TMGMYSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24112" checksum="9BE49A70D662485D" modified="2017-01-18" version="1">MEPVTLITGGSSGIGAATARGLLKQGHRVAITGRDADRLAAFATSTGAGERLLTISGDAADEHHVAATVRQVVDSWGRLDTVIANAGFSLPGTLENHDAQAMRTMVLTNVLGPALLVQQTLPHLRQSKGRIVVVGSVAGIRNTPGNMYSVTKWAAHALVENVRLLVAEDGIGVTLVAPGIVDTPFWDERGGCPDAAPALTAEQVAETILFAVNQPEGVDVSHLVVRPAGQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG36</accession>
    <name>A0A1E7NG36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2743"/>
    <dbReference type="EnsemblBacteria" id="OEV39608">
        <property type="protein sequence ID" value="OEV39608"/>
        <property type="gene ID" value="HS99_0002745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11530" checksum="41866EAC1517EE4C" modified="2017-01-18" version="1">MVDVDPMSREGLERLRLLLAERVGSPCEHGEEAARVEPLRRQVYHAVTGIDAYLSAVEAGSSTVVGLRERAQDLWADLERIALPCSRAPDTGGSRRPTTCCQEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA8</accession>
    <name>A0A1E7NGA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555658.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39523">
        <property type="protein sequence ID" value="OEV39523"/>
        <property type="gene ID" value="HS99_0002200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsH_ext" evidence="3">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13568" checksum="3E5A85F918855A42" modified="2017-01-18" version="1">MITRSRFPARHPTGRARPGPPSDPPKPAPKPAQEPPSWRRWILPIAVAVTLFVLLSRAPSGTGTRYAYTDFTGRVDAGQVKTVEITDKGAVSGTLKDGIKFTGALLGSVSQQCAQHAPCPVVIVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD5</accession>
    <name>A0A1E7NGD5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0003645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367074.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2926"/>
    <dbReference type="EnsemblBacteria" id="OEV39756">
        <property type="protein sequence ID" value="OEV39756"/>
        <property type="gene ID" value="HS99_0003645"/>
    </dbReference>
    <dbReference type="OMA" id="YCAANIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1769"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1847"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1868" mass="198208" checksum="D8A2C05AC00F61A0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH5</accession>
    <name>A0A1E7NGH5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285263.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3563"/>
    <dbReference type="EnsemblBacteria" id="OEV39794">
        <property type="protein sequence ID" value="OEV39794"/>
        <property type="gene ID" value="HS99_0000500"/>
    </dbReference>
    <dbReference type="OMA" id="REYAMLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="6">
        <location>
            <begin position="273"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="34312" checksum="EBB667661061687D" modified="2017-01-18" version="1">MEAPSLQELRQRALAAASPKAYGAGAAIVCDRLVRIFSAEGIEVQALQGLELTIQQGDLVALVGASGSGKSTLLTILAGLDVPTAGTATVAGCDLLEMSAKERLRYRREVVGFIWQQTARNLLPFLTAAENIALPMQLRGRRATTAGSKGQAARVAELMDALEIGHLAHRRPNELSGGQQQRVAIAVAMANNPPVLLADEPTGELDSETAGVIFESFRTVNRELGTTVVIVTHDPMVAAEVRRTVAVRDGRTSSEVLRRTVTDEHGEESVNEREYVMLDRTGRVQLPVKFLEALGMEHRVAVDLATDHIEIRPDDLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NHD9</accession>
    <name>A0A1E7NHD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2909"/>
    <dbReference type="EnsemblBacteria" id="OEV39873">
        <property type="protein sequence ID" value="OEV39873"/>
        <property type="gene ID" value="HS99_0003565"/>
    </dbReference>
    <dbReference type="OMA" id="PALWVTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22652" checksum="0D2F1284B3A50C0C" modified="2017-01-18" version="1">MTVRRAGRLLLDGLSAQIPGAACTALVGPSGAGKSTLLRVLNRLAEPTSGEVRFRGTPLPELDVLELRRRVGLVGQQPVLLTDRVLDDLRVGRPDLDEDRAAVLLERTGLPAGMLARATAGLSGGEAQRVCLARALAVGPEVLLLDEPTSALDADSAQAVEYTIRDLVADGLAVVLVSHNVPQARRVADHVLVLRGGRLVASGPADRVDYLRKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV45</accession>
    <name>A0A1E7MV45_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAA_hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6875"/>
    <dbReference type="EnsemblBacteria" id="OEV32299">
        <property type="protein sequence ID" value="OEV32299"/>
        <property type="gene ID" value="HS99_0016440"/>
    </dbReference>
    <dbReference type="OMA" id="SHDAVCH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="19903" checksum="D0094916BFDB01A6" modified="2017-01-18" version="1">MVFTKDRGCVAAPVGPVGIDFSLSREIDWEVELAVVIGRRAWRVDEAGALDHVFGYCVANDITARDLQTRHKQYYLSKSLPGSCPLGPWITTADEVPDPHDLAITLSVNGVLRQVSRTDQMVFSIPETIAAISRIVPLEPGDLILTGTPAGTGFAADPPSYLAPGDVVECSVEGLGTLSNRITALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVB4</accession>
    <name>A0A1E7MVB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289596.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000462.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6965"/>
    <dbReference type="EnsemblBacteria" id="OEV32371">
        <property type="protein sequence ID" value="OEV32371"/>
        <property type="gene ID" value="HS99_0016875"/>
    </dbReference>
    <dbReference type="OMA" id="VILAYDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="24573" checksum="DF8B2E9CAAC3CBF5" modified="2017-01-18" version="1">MTTVLIVDDQPLQRYGFRMLLESQPDTEVIGEAAHGAEAVRLAADLRPDVVLMDIRMPGMDGIEATRRIVAGGGRSRILVLTTFDLDEYAHAALRAGASGFLLKDARPEELLAGIRAVAEGDAVVAPAITRRLLDAYAHHLPVRPPGAAPVEDPRLEALTEREREILLAIAQGWTNSEIAQRLVLAESTVKTHVSRVLGKIGARDRVQAVIFAYDRGLTRPNPPVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVJ2</accession>
    <name>A0A1E7MVJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557438.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1200"/>
    <dbReference type="EnsemblBacteria" id="OEV32452">
        <property type="protein sequence ID" value="OEV32452"/>
        <property type="gene ID" value="HS99_0017375"/>
    </dbReference>
    <dbReference type="OMA" id="NVGCTRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="15034" checksum="66605A66C88F1C6E" modified="2017-01-18" version="1">MGVSANGAEQRQERFDRGLEVLTRVDGEGGQRVIDALADINPELAHQVVAWGFGEIYSRHELAARERQLVTLGMLTALGGCEPQLEVHINAALNVGLTPTEITEALLHSAVYCGFPKALNATFVAKKVFGERGLLPVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW0</accession>
    <name>A0A1E7MVW0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="11" type="ORF">HS99_0040095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284398.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000660.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8130"/>
    <dbReference type="EnsemblBacteria" id="ARF82811">
        <property type="protein sequence ID" value="ARF82811"/>
        <property type="gene ID" value="B6264_13400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32568">
        <property type="protein sequence ID" value="OEV32568"/>
        <property type="gene ID" value="HS99_0040095"/>
    </dbReference>
    <dbReference type="OMA" id="VVRDYVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="38422" checksum="EE8D22EDF5B0EB36" modified="2017-01-18" version="1">MRASLTAIAPGTALRDGLERVLRANTGGLIVLGFDRTVESLCTGGFVLDVEFSATRLRELCKLDGAVVLDKDITKIVRAGVHLMPDSTIPTDETGTRHRTAERVNRQTGYPVVAVSHSMRLIAMYVNGTRRVLEDSTTVLSRANQALATLERYKLRLDEVAGTLSALEIEDLVTVRDVTAVAQRLEMVRLIATEIAGYVLELGIDGRLLSLQLDELIAGVEPERELVARDYFPERAAKKGRTVTEVLGDLEALTHAELLDLQTVAKALGYSGSPESLDSAVSPRGYRLLAKIPRLPNTVIERLVEHFGGLQKLLAASIDDLQTVEGVGETRARSVREGLSRLAESSILERYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVY9</accession>
    <name>A0A1E7MVY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1174"/>
    <dbReference type="EnsemblBacteria" id="OEV32433">
        <property type="protein sequence ID" value="OEV32433"/>
        <property type="gene ID" value="HS99_0017260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12256" checksum="1A0CDD1A113E855F" modified="2017-01-18" version="1">MLRELLATVPGGDRYSEVGELLATELVGNAVLHSGMPGRLIRVSFDVDAIRLRIEVHDASDRPPLPQQPDPTAGCGRGLLLVEALATQWGHFPRPGGVGKVVWCECAAAPLVVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVZ5</accession>
    <name>A0A1E7MVZ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0015050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738011.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3810"/>
    <dbReference type="EnsemblBacteria" id="OEV32594">
        <property type="protein sequence ID" value="OEV32594"/>
        <property type="gene ID" value="HS99_0015050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="73603" checksum="28E0F44BCF16A329" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW44</accession>
    <name>A0A1E7MW44_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3862"/>
    <dbReference type="EnsemblBacteria" id="OEV32639">
        <property type="protein sequence ID" value="OEV32639"/>
        <property type="gene ID" value="HS99_0015315"/>
    </dbReference>
    <dbReference type="OMA" id="HVTLGWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1301" mass="132916" checksum="3D75D894E2A188D3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW55</accession>
    <name>A0A1E7MW55_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3142"/>
    <dbReference type="EnsemblBacteria" id="ARF82625">
        <property type="protein sequence ID" value="ARF82625"/>
        <property type="gene ID" value="B6264_04685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32654">
        <property type="protein sequence ID" value="OEV32654"/>
        <property type="gene ID" value="HS99_0015395"/>
    </dbReference>
    <dbReference type="OMA" id="LVFMMSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="22463" checksum="B7A65E71E2CC188C" modified="2017-01-18" version="1">MSELPDWMYAPRDEGWFADDLDHLPQAPRHTELIDGALVFMMSPQRWWHGDVVNDLVYTLRRQVPTGHRVGREMSIKLDKWNRPEPDVLVVQADFDPDRTQFTPDEVALVVEVVSPESVHRDRTVKFRKYAEAGIPHYWIVEEEDGLPVAHVFELEHATSSYAPAGIFRGKLERRVPFPIEIDLDGLVPASGRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE6</accession>
    <name>A0A1E7MWE6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554624.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000778.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6109"/>
    <dbReference type="EnsemblBacteria" id="OEV32762">
        <property type="protein sequence ID" value="OEV32762"/>
        <property type="gene ID" value="HS99_0016050"/>
    </dbReference>
    <dbReference type="OMA" id="GTTREHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="180"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="39890" checksum="FF8A919572E0A94E" modified="2017-01-18" version="1">MRWGTAAVVAAAAAVGAGAVVLVVGRRASERMVRPGVPGPVEPEAGPVVVHGLGVDRVIFNRRPESLRPGRWAVEWDGNGHAVVEEILYRDAQGVTRRLVRADRGTLTPGTEVRFTPRVHLGDPTEAFGLAYTETAADGELGALPAWRLDGKRGTWVILVHGPEADRQQTLPVLPTLHRLGLTALAVTYRGDEGAPAPPGGYSRFGEDEWRDVEAAVRLALDSGAGRVILHGWSVGATMVLHTAARSAWAHAISGLILDSPVLDLASAARRDAARAGFTGVSAELGTLAAQGRTGVDLADSSRLAEGADLRVPTLVLHSPDDRIAPFDTVERLAAARHDVVNLQRFPGAEHAALWNSAPEHYTELLRRWLTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWH3</accession>
    <name>A0A1E7MWH3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein HS99_0015535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3171"/>
    <dbReference type="EnsemblBacteria" id="OEV32792">
        <property type="protein sequence ID" value="OEV32792"/>
        <property type="gene ID" value="HS99_0015535"/>
    </dbReference>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="32441" checksum="3C8DBBB6AC75AFBC" modified="2017-01-18" version="1">MSDVAENAPELVIISGMSGAGRSTAAKCLEDLGWFVVDNLPPALIPTMVDLGARSQGNVARIGVVVDVRGRQFFDDLLTSLDELEKRGVRLRVVFLDSSDEALVRRFESVRRPHPLQADGRIVDGIAQERDLLRDLRGEADLVIDTSNLNVHQLRAKLDAQFADHDEPELRATVMSFGFKYGLPVDADLVVDCRFLPNPHWVPELRARTGTDADVADYVFQQPGANEFLDGYAELLRIVTEGYRREGKRYMTLAVGCTGGKHRSVAMSERLTKRLIADGVETVLVHRDMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWK4</accession>
    <name>A0A1E7MWK4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285571.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7809"/>
    <dbReference type="EnsemblBacteria" id="ARF82610">
        <property type="protein sequence ID" value="ARF82610"/>
        <property type="gene ID" value="B6264_04085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32811">
        <property type="protein sequence ID" value="OEV32811"/>
        <property type="gene ID" value="HS99_0015995"/>
    </dbReference>
    <dbReference type="OMA" id="WTLPDPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22803" checksum="BA8428D8AE14F327" modified="2017-01-18" version="1">MGDPSRAIADYWDAAAPGFDDEPDHGLRAAGTREAWGRRVRGWLPAGAVDVLDAGCGTGSLAELVAADGHRVTGVDLAPRMVARARAKLAAAGAAGRFVVGDAGAPPVRDGSFDVLLCRHVIWTLPAPERALRAWVRLLRPGGRLVLVEGRWREAGAGAQPYVAGAERLPWNGGVGAEELAAAVRPLVAELRIEPLSGDAALWGGPVDDERYAVVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM6</accession>
    <name>A0A1E7MWM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000084">
        <property type="protein sequence ID" value="OEV32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385899.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2558"/>
    <dbReference type="EnsemblBacteria" id="OEV32831">
        <property type="protein sequence ID" value="OEV32831"/>
        <property type="gene ID" value="HS99_0039935"/>
    </dbReference>
    <dbReference type="OMA" id="CADRYYS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="71"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="25963" checksum="927013FE673DD953" modified="2017-01-18" version="1">MGAVDRTAEHPEGTPVGRRVVLGLLGLGAVGVAAGPYLQRAESSLAERDPSGLSGLLPGNNGFRYYSVVTSVPERTAVDYTLTVDGLVERPATHRLADLQAMPQRRLVKDVQCVTGWRVPDTPFEGVPLAHLLDAAGVEPGAKAVRFSCFDGAYTESLTLEQARRDDVLVALRMQDNPIAHDHGGPVRLYVAPMYFYKSAKWLSGITVTDAVQPGYWERNGYDVDAWVGRSNGRDDAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR7</accession>
    <name>A0A1E7MWR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000080">
        <property type="protein sequence ID" value="OEV32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366196.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000116_gene4537"/>
    <dbReference type="EnsemblBacteria" id="ARF83366">
        <property type="protein sequence ID" value="ARF83366"/>
        <property type="gene ID" value="B6264_31090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32871">
        <property type="protein sequence ID" value="OEV32871"/>
        <property type="gene ID" value="HS99_0039665"/>
    </dbReference>
    <dbReference type="OMA" id="PLIAWMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="467" mass="50691" checksum="4DFAF0E991889262" modified="2017-01-18" version="1">MVPGILRVSPFTRETTYSLVGRVAARYGLNEAALLTHWQWRGHRPRHEGGALRADAEVVLDAAGRRVLADLCGVGEEVLGRALPAWGLEDEKLATRTGEGGPGAVWRVGGAVVGPVAFGCRSCAGRRAGAPVRVVRYAQRWERVCARHGRWLLDADADQALEFLDLRGLPEVVEAQRRWAGVVRRAVRAGVGPGEVFSVAWAVVCRWWDQALEWPDERVWPARLHALAGGDAGGDFWRWRALVRDAAVFPEVVEVAASLLDPVMAELVWRDSGAGRPRALPADGTFCRRLGERVGRPWLGPLAAVDYGGPLIAWMGAVIRRRRGVAVPPGHRDGLWWVRQELQPPSMAAQLRALTKETRLPGSGTAWRSAVAPERRMLINNLLDDAQEQLIQLRGAQRGSSAEAAERLLKGLGYSIGRLQEAARETVEGALEAGVRPEDVAVWVGMSPGALAGLLGAGGEPARQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM5</accession>
    <name>A0A1E7MXM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000074">
        <property type="protein sequence ID" value="OEV33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554008.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000532.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4421"/>
    <dbReference type="EnsemblBacteria" id="ARF78469">
        <property type="protein sequence ID" value="ARF78469"/>
        <property type="gene ID" value="B6264_05650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33198">
        <property type="protein sequence ID" value="OEV33198"/>
        <property type="gene ID" value="HS99_0039400"/>
    </dbReference>
    <dbReference type="OMA" id="GHIGFTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="20473" checksum="E2302A6532738411" modified="2017-01-18" version="1">MFERFTAAARQVVVGAQEEARGLRHGHVGTEHLLLAILAGPDDPAAEVLIGMGLDHEAARRAVVRLLGPGDDAEVLASIGVDLDAVRAAVESAFGAGALDPPVDEGPRRRGWFRSGGSKPARSPFGQGAKKALELSLRESLRLKSGEIGVGHLLLGVLRVEDGPGLRVVADHGLDPAAVRRAVEAKLSPSGSARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXP0</accession>
    <name>A0A1E7MXP0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000073">
        <property type="protein sequence ID" value="OEV33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557707.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000400.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7583"/>
    <dbReference type="EnsemblBacteria" id="ARF81766">
        <property type="protein sequence ID" value="ARF81766"/>
        <property type="gene ID" value="B6264_25280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33205">
        <property type="protein sequence ID" value="OEV33205"/>
        <property type="gene ID" value="HS99_0039285"/>
    </dbReference>
    <dbReference type="OMA" id="ESCPARA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6481" checksum="4C7D69CBABD10403" modified="2017-01-18" version="1">MRITVDTGRCVGAGQCVLNAPAVFDQDHDGVVEVHDPAAAAADPEAVALAATLCPSAAITVHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS5</accession>
    <name>A0A1E7MXS5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="7" type="ORF">HS99_0039140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290895.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000819.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5911"/>
    <dbReference type="EnsemblBacteria" id="ARF82073">
        <property type="protein sequence ID" value="ARF82073"/>
        <property type="gene ID" value="B6264_27190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33236">
        <property type="protein sequence ID" value="OEV33236"/>
        <property type="gene ID" value="HS99_0039140"/>
    </dbReference>
    <dbReference type="OMA" id="VQWMRDQ"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="414"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="506" mass="55283" checksum="7B6F7AF05047EBB4" modified="2017-01-18" version="1">MTSTGNYIAAIDQGTTSSRCIIFGADGRIVAVDQQEHRQIFPQPGYVEHDAAEIWTRVQSVVRGALEKAGLTKDDIRAIGITNQRETTVLWDKNTGEPVHNALVWQDTRTEALCRELGRNVGQDRFRRETGLPLASYFAGPKIRWLLDNVEGLRERAEAGDILFGTMDTWVIWNLTGGVDGGKHVTDVTNASRTMLMNLKTLAWDESIAESMGVPMAVLPEIRSSAEVYGEAVGDLAGVPVASALGDQQAALFGQTCFAEGEAKSTYGTGTFLLLNTGEKIVNSYHGLLTTVGYRIGDQAPVYALEGSIAVTGSLVQWLRDQLGIISTAAEIETLANTVEDNGGAYFVPAFSGLFAPYWRSDARGVIAGLTRYVTKGHLARAVLEATAWQTREVVDAMQKDSGVELTALKVDGGMTSNNLLMQNIADVLDAPVERPYVAETTALGAAYAAGLAVGFWNDLDTLRANWHRAAEWTPRMDEATREREYKKWLKAVERTMGWVEEEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY3</accession>
    <name>A0A1E7MXY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">B12-binding domain-containing radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000666.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7016"/>
    <dbReference type="EnsemblBacteria" id="ARF80411">
        <property type="protein sequence ID" value="ARF80411"/>
        <property type="gene ID" value="B6264_17195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33274">
        <property type="protein sequence ID" value="OEV33274"/>
        <property type="gene ID" value="HS99_0038975"/>
    </dbReference>
    <dbReference type="OMA" id="WYTTRER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="642" mass="71887" checksum="CB9ADC60DD660D8D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY8</accession>
    <name>A0A1E7MXY8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0038730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000066">
        <property type="protein sequence ID" value="OEV33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737991.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000114_gene3693"/>
    <dbReference type="EnsemblBacteria" id="OEV33310">
        <property type="protein sequence ID" value="OEV33310"/>
        <property type="gene ID" value="HS99_0038730"/>
    </dbReference>
    <dbReference type="OMA" id="ATCREHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1506"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2027"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2592"/>
            <end position="2662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2715"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2740"/>
            <end position="2756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="2757"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2775"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2789" mass="288126" checksum="F7B8A5D9383C2FD6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR6</accession>
    <name>A0A1E7MYR6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388503.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4009"/>
    <dbReference type="EnsemblBacteria" id="ARF80486">
        <property type="protein sequence ID" value="ARF80486"/>
        <property type="gene ID" value="B6264_17615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33383">
        <property type="protein sequence ID" value="OEV33383"/>
        <property type="gene ID" value="HS99_0012390"/>
    </dbReference>
    <dbReference type="OMA" id="AMACCVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="12988" checksum="25FCF957309EA056" modified="2017-01-18" version="1">MTTAVLHGAAAFALPERFRQLPRLAAFALLPWLMLLAVNHETPWVVLDLAEFAALLSLDALLRRRSAAAPWLGGAVALLLAGDALADTACAGPGHAVLAALVMACCVELPLAAVCVLLGREAIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS3</accession>
    <name>A0A1E7MYS3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6592"/>
    <dbReference type="EnsemblBacteria" id="OEV33595">
        <property type="protein sequence ID" value="OEV33595"/>
        <property type="gene ID" value="HS99_0012840"/>
    </dbReference>
    <dbReference type="OMA" id="YPYGPVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="307"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="42866" checksum="797548101EB33702" modified="2017-01-18" version="1">MSSSSPSPGGPPEPWRPPWVRAARAGLPVGLAAVVALVQVVGSGFAARHQGERVPLDAFGYLLLLVGPALLVLRGRRPVAAVAGTSVVTAAYLAAGYPYGPVFASWVIACCSAIGRGHRRAAWAGVGGVYLVHVLATFVLPDGWQRAPRSKFVWQEELGLLAWLLLVLAIAELLRFRRERIAAHRAYRQQLDQRRANEERLKMARELHDILAHSLSLINIQAGVALALLDRRPEEARTALVTIKSTSKEALGEVRQVLATLRGPGEAPRGPAPGLGRLDELTEQADRVGLAVEVLEDGERRPLSATVDLTAFRIVQEALTNVIRHSVAREAVVVLDWRDAAVLVVRVEDPGPGVVGDAGGSGSGLVGMRERAAAFGGTITAGPLPGGGFRVRAELPTPKAESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT2</accession>
    <name>A0A1E7MYT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82912">
        <property type="protein sequence ID" value="ARF82912"/>
        <property type="gene ID" value="B6264_18475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33610">
        <property type="protein sequence ID" value="OEV33610"/>
        <property type="gene ID" value="HS99_0013255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045701">
        <property type="entry name" value="DUF6059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19534">
        <property type="entry name" value="DUF6059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7817" checksum="ADED9CFFDCDA36FD" modified="2017-01-18" version="1">MLLRGLAALGQMAGYVAPPPQPGPVRRPGEPGGPAGGGPPSGHPERLRPDVPLSPVERRLSRRLRRVSGWTEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF2</accession>
    <name>A0A1E7MZF2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0037665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557997.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000377.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4529"/>
    <dbReference type="EnsemblBacteria" id="ARF80386">
        <property type="protein sequence ID" value="ARF80386"/>
        <property type="gene ID" value="B6264_17040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33807">
        <property type="protein sequence ID" value="OEV33807"/>
        <property type="gene ID" value="HS99_0037665"/>
    </dbReference>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="881" mass="94748" checksum="09178D64EFBF8F38" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH4</accession>
    <name>A0A1E7MZH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557791.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4399"/>
    <dbReference type="EnsemblBacteria" id="ARF80316">
        <property type="protein sequence ID" value="ARF80316"/>
        <property type="gene ID" value="B6264_16635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33842">
        <property type="protein sequence ID" value="OEV33842"/>
        <property type="gene ID" value="HS99_0037535"/>
    </dbReference>
    <dbReference type="OMA" id="WRYIIGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="313" mass="32449" checksum="97A3246A9E19DC13" modified="2017-01-18" version="1">MSPRHMALAVLVAAVWGLNFVLIHVGLDSFPPLLFCALRFAVVAVPAVFFVGPPRVARRWVLAVGVVLGVVKFGLLFMGMHAGMPAGLSSLVLQGQAGFTALFAAVLLRERPGRRRLLGLATAFAGIALSAFDQGLGGPFGAFVLVVLAAVAWGLANVLTRKASPPDALRWMVWVSAVPPLPLLALSLLVEGPGADLRALRGMTLGGLGTIAYVGLLSTLFGFVAWSYLLRRYDATAVAPYSLLVPVFGMSSAWLLLGERVSPTGAAAALLVIAGIGITALRPGAPSAAAARLRGSGPRRRAALAAAPPRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV8</accession>
    <name>A0A1E7MZV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylation/crystallin J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551706.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2191"/>
    <dbReference type="EnsemblBacteria" id="ARF77822">
        <property type="protein sequence ID" value="ARF77822"/>
        <property type="gene ID" value="B6264_01775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33966">
        <property type="protein sequence ID" value="OEV33966"/>
        <property type="gene ID" value="HS99_0010930"/>
    </dbReference>
    <dbReference type="OMA" id="ILELWVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="14221" checksum="9B175EC263E3F9FE" modified="2017-01-18" version="1">MTSQSVQPPPPTTTLWRPTGPEELALVEAAGWRAWPPRLPEQPIFYPVLNEDYAIRIARDWNVPASGVGYVTRFEVETEFVARYPVQRAGGRTILELCVPADELAEFNRHIVGRIEVVHAFRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E6</accession>
    <name>A0A1E7N0E6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,2-phenylacetyl-CoA epoxidase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030234269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2163"/>
    <dbReference type="EnsemblBacteria" id="ARF77797">
        <property type="protein sequence ID" value="ARF77797"/>
        <property type="gene ID" value="B6264_01630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33943">
        <property type="protein sequence ID" value="OEV33943"/>
        <property type="gene ID" value="HS99_0010790"/>
    </dbReference>
    <dbReference type="OMA" id="GWPLYEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="11135" checksum="9E59EB1B182A6732" modified="2017-01-18" version="1">MTESKAGWPLYEVFVRPRRGLNHVHVGSLHASDDRMALLAARDLYTRRNEGVSLWVVRSDAITASTPDERDPFFEPSGDKVYRHPTFYDIPEDVPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F6</accession>
    <name>A0A1E7N0F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2178"/>
    <dbReference type="EnsemblBacteria" id="OEV34156">
        <property type="protein sequence ID" value="OEV34156"/>
        <property type="gene ID" value="HS99_0010865"/>
    </dbReference>
    <dbReference type="OMA" id="WAHLLRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18650" checksum="F5FAD71BA4C35894" modified="2017-01-18" version="1">MNAPLSPLSPLSPLTPDAPHAPLSPNALRTVVRELAEQPEQWIHLVRLSTDERWYQRLVAEDDHEVWLISWLPGQSTGFHDHGGSRGAFAVALGELEELSLGGPDQGLLIRRVPAGTARAFGPEYVHDVRNTASGPAVTLHAYSPPLSSMAHYDLRAGGLVRTSEEGPEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G8</accession>
    <name>A0A1E7N0G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NarL family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386938.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1979"/>
    <dbReference type="EnsemblBacteria" id="ARF79575">
        <property type="protein sequence ID" value="ARF79575"/>
        <property type="gene ID" value="B6264_12210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34190">
        <property type="protein sequence ID" value="OEV34190"/>
        <property type="gene ID" value="HS99_0037060"/>
    </dbReference>
    <dbReference type="OMA" id="GPAVLCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="30711" checksum="A14F67614BEDB0DA" modified="2017-01-18" version="1">MRILLLGGDGFLGRHASAVLRSLPGATVLTAGRRPAHDLRLDLGTAQAGPLGEELAALAPDVVVNFAGAVAGSAVKLAEVNARGPAVLCEALALGTPKARLVHIGSAGEYGVCAEGESLTEQADARPVGVYGATKLAGSLAVAGSPLDAVVLRVFNPVGPGAPAGSLPGRLAAELRRVAPEGADGVVTVGDLSAYRDFVDARDIARAVGLAVSADRPLPRVLNLASGRAQPVRAIADGLVAASGFTGRIDESGAGSERSAGVSWQQADVSAAARELGWHPETVLADTLRDLWLDTDGPASTPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H9</accession>
    <name>A0A1E7N0H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387502.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000974.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1966"/>
    <dbReference type="EnsemblBacteria" id="OEV34198">
        <property type="protein sequence ID" value="OEV34198"/>
        <property type="gene ID" value="HS99_0037125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="9544" checksum="B4F32A6618B8454E" modified="2017-01-18" version="1">MSRLMTSNPKAGDGSADEPVGGAALHAGPPQDPPETESERRRRRAVFLRELTEARELRERVQPRRTKERRMREAMRMRTFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K7</accession>
    <name>A0A1E7N0K7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388086.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000614.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1948"/>
    <dbReference type="EnsemblBacteria" id="ARF79601">
        <property type="protein sequence ID" value="ARF79601"/>
        <property type="gene ID" value="B6264_12360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34212">
        <property type="protein sequence ID" value="OEV34212"/>
        <property type="gene ID" value="HS99_0037210"/>
    </dbReference>
    <dbReference type="OMA" id="DNMVLTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="505" mass="51358" checksum="0E8AC98D7B8BEC01" modified="2017-01-18" version="1">MDRHPRRWLILVVLCLSSLVLVIDNMVLTVSVPPIAEDLKAGAQDIQWIIDSYILVFAGLLLTSGSLSDRFGRRKVMIIGLALFGAASLVAAVAASPGELIAGRVLMGVGGALVMPSTLSILITVFDDEERPKAIAAWSAVAMIGLVGGPVLGGALIAHFWWGAVFLLNVPVAAVAIVAAGVLMPESKGPWRKPDLPGMLLSMVGMTALVWSIIVLPRDGFAHVGTLASMAVAVAALTAFGIRQVRTDSPMVPLKLFRNRVFTGASFSLVLLTFATGGLMLVLTQYLQFVLEFTPTDTGLAFIPLAVASLAFNVIGAALGKKLPARVLTAVGMVIIAAGFGLLATLSVGDGFTKVALAMLVLGIGSGLGMPAAANALMGAIPGEHAGVGSALNDTIQQSGAALGVAILGTVLSSTYTGSMPADAPASARHAITDALALSAGSGDTGLARAAREAFNTATSTTFTVSGIAVLAAAVLTLVLMRGTAAAQAPAEPAEAAEPAVEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P3</accession>
    <name>A0A1E7N0P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285647.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6079"/>
    <dbReference type="EnsemblBacteria" id="ARF78168">
        <property type="protein sequence ID" value="ARF78168"/>
        <property type="gene ID" value="B6264_03880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34252">
        <property type="protein sequence ID" value="OEV34252"/>
        <property type="gene ID" value="HS99_0036980"/>
    </dbReference>
    <dbReference type="OMA" id="MNMAVVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="63" mass="6568" checksum="84581A384172854E" modified="2017-01-18" version="1">MNLAIVGLVVGMALGFAGYFGGFAAFLLVAALGLVGFVAGRLLESDIDLGDLGDLLRGRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T8</accession>
    <name>A0A1E7N0T8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ORF">HS99_0036585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7635"/>
    <dbReference type="EnsemblBacteria" id="OEV34310">
        <property type="protein sequence ID" value="OEV34310"/>
        <property type="gene ID" value="HS99_0036585"/>
    </dbReference>
    <dbReference type="OMA" id="RTDWAEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="25044" checksum="EED0FDC81D16BD4C" modified="2017-01-18" version="1">MAEESEAAGGGMPAERSPGGAEAAGHGGVAASPTRARRGRRSARSEEGPPGEETGAARTSRKRAEEESDPESRARDICLRLLTGAAKSRKQLADALRKREIPEDVAEEVLTRLEEVGLIDDAAFAAAWVESRHAVRGLSRRALTQELRTKGVAADVVEQAVAQLDHDDETDAARALVERKLRSTRGLDPQVRTRRLVGMLARRGYSEGLAFRVVRGALEQEASGERSGTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N105</accession>
    <name>A0A1E7N105_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386084.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3932"/>
    <dbReference type="EnsemblBacteria" id="OEV34378">
        <property type="protein sequence ID" value="OEV34378"/>
        <property type="gene ID" value="HS99_0036270"/>
    </dbReference>
    <dbReference type="OMA" id="EMGIYTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="565" mass="61641" checksum="EEB021E6E1466BFE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N133</accession>
    <name>A0A1E7N133_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0011610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386548.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2333"/>
    <dbReference type="EnsemblBacteria" id="OEV34173">
        <property type="protein sequence ID" value="OEV34173"/>
        <property type="gene ID" value="HS99_0011610"/>
    </dbReference>
    <dbReference type="OMA" id="HNEIGAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198741" evidence="3">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="42448" checksum="DE97755E4637E092" modified="2017-01-18" version="1">MLGLVAGGVAALTATGAASAATTDAGTGLGSNWYASAPYLMPEDNSPPDAAAVMDAAGQRAFQLAFILAQGNSCSPAWGGTSSIDSDTTMPAVIQTVRGKGGDVSVSVGGYGGTKLGQVCGTPEATAAGYQRVITKYNLKAIDFDLEEPEYENTAAIHNEIGAARILQQNNPGLYVSITTAGTTAGTGWFGTQMLNEAKSQGFTPNNFSIMPFDGGFNGAAAQTDALVKFNQILQTTFGWNEATAYAHEGVSMMNGRTDAAEYFRQADFQAVLDFATAHGLARYTYWSVNRDRQCAGNVDPGLSGSCSSVAQNDWDFTKYTVKFAGATPPTTPPTTPPSTPPTGPGTPSGTPTGNPGVCTAPAWSASTTYTAGAKVSYNGHNYHAKWWTLNEVPSASGQWGVWADDGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N166</accession>
    <name>A0A1E7N166_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="17" type="ORF">HS99_0035640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552304.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1076"/>
    <dbReference type="EnsemblBacteria" id="ARF78963">
        <property type="protein sequence ID" value="ARF78963"/>
        <property type="gene ID" value="B6264_08555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34440">
        <property type="protein sequence ID" value="OEV34440"/>
        <property type="gene ID" value="HS99_0035640"/>
    </dbReference>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:lipid A biosynthetic process"/>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MobA-like_NTP_Trfase"/>
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        <property type="entry name" value="Trimer_LpxA-like_sf"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
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    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="9"/>
            <end position="150"/>
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            <begin position="85"/>
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            <begin position="397"/>
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            <position position="27"/>
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        </ligand>
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            <dbReference type="EMBL" id="OEV34440.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
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    <sequence length="488" mass="50741" checksum="2AAAF5939C881302" modified="2017-01-18" version="1">MGANSLAAVVVLAAGGGTRMKSNKLPKVLHEVCGRSLVGHAVSAAGELTPGQLVVVVGHQREQVEEHLAAHYPGVRPVVQEEQNGTGHAVRTALEALAADGVTLDGTVIVTAGDSPLLTGDTLRRLAKSHEAQQNGVTVLTAVVPEPFGYGRILRDEDGTVAAIVEERDATDTQRAIAEINSGVFAFDAKLLTEALAELTTDNSQGEEYLTDTLEILRKAGHRVGAVVAEDHRDILGINDRVQLAQARRLLNDRLLEQAMRAGVTVVDPATTWVDVQVTYEPDAVVLPNTQLQGTTHLGEGCEVGPNSTLKDTLVGAGARVSNTTADRAEIGELAATGPYAYLRPGAKLARKAKVGTYVEVKNSELGEGAKVPHLSYIGDATIGEGTNVGAASVTVNYDGVNKHRTVIGAHCRTGSDNMFIAPVTVGDGAYTGAGSVISTDVPPGALGVNRAQQRNIEGWVERKRPGTVSAQAAKAAVDGAGDGAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1C2</accession>
    <name>A0A1E7N1C2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
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    <dbReference type="EnsemblBacteria" id="ARF78925">
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        <property type="gene ID" value="B6264_08350"/>
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        <property type="gene ID" value="HS99_0035845"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
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        <property type="entry name" value="HTH_MarR-typ"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17297" checksum="506172E2B78FC5F6" modified="2017-01-18" version="1">MTTPSPQATDRTEPVHTQLQYQLAVFARRMEQVRTSGGVGTLDRAAYLLLDRLERHGPANVKALAEALGVDSSTVTRQVAPLVAAGLVGRVQDPADRRAVRLALTSCGTGRLAEVRDGRAELTRRLVAGWPPEEQRAFCALLARFNLAMESYTADQQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J0</accession>
    <name>A0A1E7N1J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5565"/>
    <dbReference type="EnsemblBacteria" id="ARF79352">
        <property type="protein sequence ID" value="ARF79352"/>
        <property type="gene ID" value="B6264_10845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34560">
        <property type="protein sequence ID" value="OEV34560"/>
        <property type="gene ID" value="HS99_0035315"/>
    </dbReference>
    <dbReference type="OMA" id="KVYCPRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18261" checksum="9C179043FDB8B017" modified="2017-01-18" version="1">MYGYDQNAYPGGPYQQQAGPQPGMNGMPGPDAYGAQGQASQQSLYPEPSPPSLADAVRAFTTGSMAVEDFQAIFITSKVHCPRGERPGFLALHNTPTPVIPMFSSLKELRRYAGKDSKHFTVTGAEVLDLLPTGYGFALDMEGEHRMVFDAKAVEQMVDFTMRRMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L8</accession>
    <name>A0A1E7N1L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5594"/>
    <dbReference type="EnsemblBacteria" id="OEV34572">
        <property type="protein sequence ID" value="OEV34572"/>
        <property type="gene ID" value="HS99_0035175"/>
    </dbReference>
    <dbReference type="OMA" id="CKWILAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="36"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="246"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="46984" checksum="7982E1D06B2BF5F2" modified="2017-01-18" version="1">MNNVQNTDTTGRSGRNPLRALGNAIRSCLRGPVLAALAVPQLLLLTAATVAASLLGLGVGALLVPPTIVAIRGLAGLRRRLAADWTGVEIRDPYQPLPDAEAGFKGAWKRCQAMLSDQATWRDLLWLLVDPMVGFTLAILPLTVVAYGVLGLVLPQFWQSIADNGGNTWYLWIHVTSSGAAGTAALFGVPVMLAGLAVAPAVMRAHTALAKSLLGPTARAEALAAERKVAHLTETRRDALTTQAAELRRIERDLHDGAQARLVAMGMNLGVAERLVERDPEAAKQLLAETRQASASALNELRDLVRGIHPPVLADRGLADAVRALCMDSPLNVTVSAELPGRPEAPVESALYFAVSEALTNAAKHSGASHVDVQLWYENGTLKAQITDDGTGGADPSRGTGLRGLERRLATFDGVLAVRSPLGGPTTLTMELPCELYSRRTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L9</accession>
    <name>A0A1E7N1L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0035130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6125"/>
    <dbReference type="EnsemblBacteria" id="OEV34571">
        <property type="protein sequence ID" value="OEV34571"/>
        <property type="gene ID" value="HS99_0035130"/>
    </dbReference>
    <dbReference type="OMA" id="TGHRVRY"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="957"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2022"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2361" mass="250600" checksum="BD023614DBAAEF43" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q6</accession>
    <name>A0A1E7N1Q6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554759.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000116.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82018">
        <property type="protein sequence ID" value="ARF82018"/>
        <property type="gene ID" value="B6264_26835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34617">
        <property type="protein sequence ID" value="OEV34617"/>
        <property type="gene ID" value="HS99_0008955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="28120" checksum="94E46CDFE97C6900" modified="2017-01-18" version="1">MIPAGRIPADDKRAAELFGLSLSRYRTVQPWKKFPPSVKYLQSPAAKVRVYDLEQLKIQVINMMVEEGAKQENPLLPRDPEILLPQKAGEVPQLKPGVTLQENDLLDRYEAYAAIPEKDRPAWSTWLRLIAPPSGGATTAGPETDDEFDIAGARYWRYRTLMDWNAKRIPQHATGHGHGRPAGPETPGIRQPRRDFIERVEKTRRLLADDPNRTNAELALALGVKSERTVERILAFLEEERAGGNQQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N242</accession>
    <name>A0A1E7N242_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-ACP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289536.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6122"/>
    <dbReference type="EnsemblBacteria" id="ARF79319">
        <property type="protein sequence ID" value="ARF79319"/>
        <property type="gene ID" value="B6264_10665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34533">
        <property type="protein sequence ID" value="OEV34533"/>
        <property type="gene ID" value="HS99_0035145"/>
    </dbReference>
    <dbReference type="OMA" id="HIIDGIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="42812" checksum="1B4E98F75330B4D2" modified="2017-01-18" version="1">MNEPQRVVVTGIGVLSSIGNGVEEFTSALREGRCGAGPITSFDTTGFLRTFGHEVDGFRPEQWIHRLPVEQLGRATQFAVAAARMAVQDAGLDEQELAGLRAQITVGTTDGEAAELDKMMAESVAKGPEHPADQLVAGRLPSHQLALAIARELRLPRAVPAVLGTACAAGNYAIGDGFDAVRSGEADIAVVGGADAICRRTFAGFSRLGLVSSDFCRPFDADREGLLTAEGAGVLVLETLESARHRGARIYAELLGYGLNCDAHHPTAPDQASVARCMELALADAGVKANEVDLVSAHGTGTPTNDITETRAIREVFGDNPPRTVALKAMLGHSMGAASALGAAASALALAHGFVPPTVNHRTTDPQCQIDCVPNHSVPADLRVVVNNGLAFGGNNASVVLGRHDEELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N273</accession>
    <name>A0A1E7N273_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555807.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4584"/>
    <dbReference type="EnsemblBacteria" id="ARF81866">
        <property type="protein sequence ID" value="ARF81866"/>
        <property type="gene ID" value="B6264_25915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34771">
        <property type="protein sequence ID" value="OEV34771"/>
        <property type="gene ID" value="HS99_0009840"/>
    </dbReference>
    <dbReference type="OMA" id="SHYQAMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="36763" checksum="44B568064E2BF995" modified="2017-01-18" version="1">MAASIIDVARAVGVSPSTVSRALRGRDGVSDELRVRIIAVAADLGYTASRNASSLASGRTCSIGVLAPYVGRWFFGTVVDAAERVFSAAGYDLLLYNLGSVDSRKRFFAELPVRKRVDAILSLLIPTGDEAERLRSLGIPLAITVGGPRPGFTTVGIDDRAGAELATRHLVNLGHRRIGRIGTRPSAPLYWTTPDLRRRGYLDVLVDAGIPHDPDLEADGEYTVEGGERAMTRLLTAVRPPTAVFAESDEMAMGALRALRAHRLRVPEDIAIVGFDDHELADVVGLTTVAQPVAEHGTQAASLLLRLLRDDTDVPDHVELPTHLIVRNSTAPHRGSLHGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2K7</accession>
    <name>A0A1E7N2K7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366423.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5880"/>
    <dbReference type="EnsemblBacteria" id="OEV34924">
        <property type="protein sequence ID" value="OEV34924"/>
        <property type="gene ID" value="HS99_0035015"/>
    </dbReference>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017832">
        <property type="entry name" value="Glyco_trans_2_hopen-assoc_HpnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03469">
        <property type="entry name" value="HpnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="388" mass="41640" checksum="48C050BAA887B5FE" modified="2017-01-18" version="1">MRQTAGVTVLLWIAAFSLLVWLWLACCHGLFWRTDVRLPPRRPPVRWPRVVVVVPARDEAAVLPVSLPTLLAQKYPGRARVILVDDHSADGTGALAAELRTMDGLELTVTSPPPLPPGWTGKLWALRHGVELAGTDAEYLLLTDADIAHGPDSLAELVAAAEGNGLDLVSQMARLRVETGWERLIVPAFVYFFAQLYPFRRSNRPGSRTAAAAGGCSLVRREALERAGGVAAIRGAVIDDVSLARAVKSSGGRTWLGLAGEVDSVRPYPRLEQLWRMVSRSAYAQLRHSPLLLLGTVLGLALVYLVPPVATVAGLVAGAPPVAVAGGAAWALMAGTYLPMVRYYGQPVAAVLLLPFTASLYLLMTVDSAVQHWRGRGAAWKGRTYSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R7</accession>
    <name>A0A1E7N2R7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ORF">HS99_0034630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287992.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7680"/>
    <dbReference type="EnsemblBacteria" id="ARF82662">
        <property type="protein sequence ID" value="ARF82662"/>
        <property type="gene ID" value="B6264_06130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34991">
        <property type="protein sequence ID" value="OEV34991"/>
        <property type="gene ID" value="HS99_0034630"/>
    </dbReference>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="521" mass="55145" checksum="90B6CC66C868E5C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y0</accession>
    <name>A0A1E7N2Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556968.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3216"/>
    <dbReference type="EnsemblBacteria" id="ARF81827">
        <property type="protein sequence ID" value="ARF81827"/>
        <property type="gene ID" value="B6264_25650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34813">
        <property type="protein sequence ID" value="OEV34813"/>
        <property type="gene ID" value="HS99_0010095"/>
    </dbReference>
    <dbReference type="OMA" id="WLPAFAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="18888" checksum="8BF5033F4535D57B" modified="2017-01-18" version="1">MRWLTLYARSRRVPTSAAAVTLVALAAWALNHNGAGPMGLGIAVLILTANVTAASVGLGGPDVALERTAAIRWAPRRAAHALLAGAVAGAALLATQAAGAELAPAALVVRDSAGLIGLAALGAVLFGAHFAWTLPIGWLAVTLLVPVPPGIAGEVGGWMIISPATTASATTAWALLATGTVLYAAAGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y6</accession>
    <name>A0A1E7N2Y6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0034475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284799.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000729.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4720"/>
    <dbReference type="EnsemblBacteria" id="OEV35040">
        <property type="protein sequence ID" value="OEV35040"/>
        <property type="gene ID" value="HS99_0034475"/>
    </dbReference>
    <dbReference type="OMA" id="IAQSAMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="43"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30454" checksum="AE1D6816ED01CFCD" modified="2017-01-18" version="1">MSAVPAARPTASAEPPDRGPELDLLLVPPRARTGWRLVPARIAAMCAVELQKLRHDRTELYTRAVQPALWLLIFGETFTRLKAIPTGGIPYLDYLAPGIIAQSAMFIAIFYGIMIIWERDSGVLTKLLVTPTPRAALVTGKAFAAGVKAVLQAVVVVLIAAVLGVAMTWNPLRLLGVVAVVLLGSAFFSCLSMAIAGIVLTRDRLMGIGQAITMPLFFGSNALYPLDLMPGWLQAVSKVNPLSYQVDALRGLLIGTPSHLPLDFAVLAAATLAGIAAASALLGRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N340</accession>
    <name>A0A1E7N340_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286635.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000407.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene400"/>
    <dbReference type="EnsemblBacteria" id="ARF78903">
        <property type="protein sequence ID" value="ARF78903"/>
        <property type="gene ID" value="B6264_08220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35100">
        <property type="protein sequence ID" value="OEV35100"/>
        <property type="gene ID" value="HS99_0034130"/>
    </dbReference>
    <dbReference type="OMA" id="KWGLSYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009148">
        <property type="entry name" value="SibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01852">
        <property type="entry name" value="SIBAPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063978" evidence="2">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="24939" checksum="9398C7FE908D8230" modified="2017-01-18" version="1">MTRISVRGVAVASATAVTAVGAVVGMASGSEGKTTQTVDVAGATLLAEVPSGAQAQTVSDNIGQQASAQQASADAAAKAAAEQKAAEEAARQKAAADAQAKADAQAKADADKAAKAAADQRAADAAAANRSKSRSAMAAVDDSAPAVSVSPGSVQDMARQIVGNDTQFQCFSQIVKRESGWDYTATNSGSGAYGLVQALPGSKMASAGADWRTNPATQIKWGLSYMNSRYGSPCGAWSFWQAHSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N359</accession>
    <name>A0A1E7N359_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285356.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4424"/>
    <dbReference type="EnsemblBacteria" id="ARF78467">
        <property type="protein sequence ID" value="ARF78467"/>
        <property type="gene ID" value="B6264_05635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35131">
        <property type="protein sequence ID" value="OEV35131"/>
        <property type="gene ID" value="HS99_0033620"/>
    </dbReference>
    <dbReference type="OMA" id="MQSEHVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13141" checksum="BE0D4CDC4DC5080C" modified="2017-01-18" version="1">MTGGPALPGRDDDPDRLYTITGGRSRAPENAFDLVTLIVAERQPTPGMQSEHARILRMCEAPTAVVEVAAELSLPVSVAKILLGDLLESGAVTARHPRFAPNKARLPDLDTLKQVLHGLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U8</accession>
    <name>A0A1E7N3U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550622.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2418"/>
    <dbReference type="EnsemblBacteria" id="OEV35357">
        <property type="protein sequence ID" value="OEV35357"/>
        <property type="gene ID" value="HS99_0032600"/>
    </dbReference>
    <dbReference type="OMA" id="YYGSRAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198726" evidence="2">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="420" mass="46323" checksum="696550886E5C7E31" modified="2017-01-18" version="1">MRTARGAVVLLAVGVVASLTLTTGDSFSRGRPNAAAPDPTAPEAEPEPEPAGTPAPTPTPTPTWDGKVHVLGDGSTSYTGPQPKQPTPEKLKPGEKPPQFVVFSWDGGLEGDDHLFSRFRKLGAENNAQMTYFLSGIYTLPKSKRTLYHPPQHDPGAASIDYATDAHIKDTLEQLRLAWLDGNEIGTHFNGHFCGKKGGDDWSAEEWKSELDQAVSFVTNWKTNTGYKDLPPLPFDYTKELVGGRAPCLEGQKNLLPAEKAAGFRYDASSPGEFQVWPSKKDGIWNFPLQLLPFPAKGSQGLSMDFNFLAGQSGNTSKGDPKKFDEWEKETKESYLAGFERVYNGSRAPLFIGNHFEDWNGGIYMQAIEDVVKDVCHRDGVRCVTFRQVADWLDTQDPKVLDKLRQLDPGQPADWSRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y9</accession>
    <name>A0A1E7N3Y9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386205.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2436"/>
    <dbReference type="EnsemblBacteria" id="OEV35400">
        <property type="protein sequence ID" value="OEV35400"/>
        <property type="gene ID" value="HS99_0032515"/>
    </dbReference>
    <dbReference type="OMA" id="WLPDQEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="12957" checksum="48A6CDF0AB8259A1" modified="2017-01-18" version="1">MLVTLGGAEILFTLWAPLPLLLHISLVGLAGYLVPSVMLLCGLLILFNPTQRLFYSVLAVLASLASWVTSNLGGFLIGMLLGVVGACLTFGWLPDQPLRRGRQRREDRRAQRRAARAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D1</accession>
    <name>A0A1E7N4D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388293.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5522"/>
    <dbReference type="EnsemblBacteria" id="ARF82759">
        <property type="protein sequence ID" value="ARF82759"/>
        <property type="gene ID" value="B6264_11050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35551">
        <property type="protein sequence ID" value="OEV35551"/>
        <property type="gene ID" value="HS99_0031860"/>
    </dbReference>
    <dbReference type="OMA" id="RHITYDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28298" checksum="A7A5D6B3AD1B22C2" modified="2017-01-18" version="1">MLPVEDTALAVTDTGGDGRPVLYLNGSYCTRKDWRRVIAELGDGYRHITFDERARGKSRKSADYSFEACLRDIDAVLAATGARNPIVVGWSYGAALALHWSTRNPDRLAGAVMVDGGYPWDYLATVEGGREAGKEQIRTLFKRFGPLMPLVRPLGMAARMSAAQHAEINIELNEIVAESGPVFDLVTFPMRFLVATGASLGGTDEGLTAMRATLDPILARNPDVQVSATVPSKHTTIVRKDFRAIADAVREVAALRPGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D6</accession>
    <name>A0A1E7N4D6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5524"/>
    <dbReference type="EnsemblBacteria" id="OEV35550">
        <property type="protein sequence ID" value="OEV35550"/>
        <property type="gene ID" value="HS99_0031850"/>
    </dbReference>
    <dbReference type="OMA" id="PCESVRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="22360" checksum="46F6E29CADBC20A5" modified="2017-01-18" version="1">MGGSAPRDAQDRTAFTAPADAERLARTAAALAARGFAVEVLDDAAAARVRIRELIPVGAAVFTAASETLRLSGIDEDLNTDDRYRSVRSRVLTMDRTTEADDIRRLLAAPDVAVGSVAAVTETGSLVIASASGSQLPGNAGGAGQAIWVVGAQKVVPDLACAQRRLEDHVLPLEDTRALAAYGQPSAVNQVLVLNAPTRFSRGTVLLLREAIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T4</accession>
    <name>A0A1E7N4T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin biosynthesis protein CbiX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828828.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene891"/>
    <dbReference type="EnsemblBacteria" id="ARF80879">
        <property type="protein sequence ID" value="ARF80879"/>
        <property type="gene ID" value="B6264_19945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35682">
        <property type="protein sequence ID" value="OEV35682"/>
        <property type="gene ID" value="HS99_0007175"/>
    </dbReference>
    <dbReference type="OMA" id="WCAVRPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="24665" checksum="54AE25D26C0589BC" modified="2017-01-18" version="1">MMPALLLIAHGSRDPRHAATVAALVGQVRAQRPALEVATAYLDHCAPRIPQVVGRLADAVAVPLLLNRAFHAKHDIPAALRAAGSSLPLADVLGPSPLLLAALDRRLAEAGLDVGSAAVRSRTGVVLAAAGSSDPAADAATRAVAAEWRRTRGWAAAEVAYASAAGPRVPDALAALRAAGATHTAVAPYLLAPGLLPDRIAAASTDADTVADPLGPAPELAALLLQRYDRARLTAPVVPALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R1</accession>
    <name>A0A1E7N5R1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737899.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene500"/>
    <dbReference type="EnsemblBacteria" id="OEV36018">
        <property type="protein sequence ID" value="OEV36018"/>
        <property type="gene ID" value="HS99_0031405"/>
    </dbReference>
    <dbReference type="OMA" id="WQERCGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="673" mass="71610" checksum="D425B4CE6ADE848F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5T4</accession>
    <name>A0A1E7N5T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6341"/>
    <dbReference type="EnsemblBacteria" id="OEV36052">
        <property type="protein sequence ID" value="OEV36052"/>
        <property type="gene ID" value="HS99_0031635"/>
    </dbReference>
    <dbReference type="OMA" id="VFAQYHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="241"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="50041" checksum="8AE376356C3120B6" modified="2017-01-18" version="1">MAALCCLLPLLPQAVAPGVPQWLGHPVDWPKVGLLGFLHGCWESLAQGLPTPCSVLLRRLLRRPVPAGRAPARPGVNAFFPVLFAGVLMLPPAAAALVAAPAALLGGPTGPGCRGRQLFNGSQLALCAFAASVAFHLLHGPQLLLGSRFPAALLPGFAAVATFCLVNGLVVGVMVVLSEDRRAGEVLRGACAVCGLPVLVHAAGGLMVAVLWQGPYGAFAALLALLPLSISAWVFAQGQRERDAHQATVQSLVQAVEIKDAYTRGHSERVGRASVLIATQLGMEPERLRTLRFAGILHDVGKLGVATELLRRNGPLSEDERRAVEIHPVYGYELVRGIDFLGEAHAGILHHHERMDGRGYPSGLAGEQIPEFARIISVADAFDSMTSTRSYRRGRPVTEAVTELERCSGSQFDPVMVRALIDALAVHDWQPVEYSEDCVRAVPDIPLGVPEPVRAAPGRVPAQGGTVPAAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6B1</accession>
    <name>A0A1E7N6B1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286140.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7233"/>
    <dbReference type="EnsemblBacteria" id="ARF82975">
        <property type="protein sequence ID" value="ARF82975"/>
        <property type="gene ID" value="B6264_21100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35993">
        <property type="protein sequence ID" value="OEV35993"/>
        <property type="gene ID" value="HS99_0008320"/>
    </dbReference>
    <dbReference type="OMA" id="LPMCGTS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33723" checksum="13D60E31CF3164A5" modified="2017-01-18" version="1">MLSLVTYLRERPGAEVAEVARAFGISERELIGDLNVLPMCGTSFRGGDLLDIDTDGERIWWHNVDDVAQPLRLAADEATALLVAARAVAGLPGLRAGDREALTRAVAKIENAAGESAEGSARVGVTFEAESHVFADIDRALSEGRRVWLRYYSHGRGGMTEREVDPIRLLTEGHTYLEAWCRTSEDHRMFRLDRVAEIRVLDVPADPPRREPRDLSGGLVNPAADDPEVVVEVSSGGRWVAEYYTHDRAEELPDGGLRITLRSADPSQLRPLALRLGRDGRIVSPPELAEQARSAAREALAAYGEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P7</accession>
    <name>A0A1E7N6P7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0029750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7162"/>
    <dbReference type="EnsemblBacteria" id="ARF82361">
        <property type="protein sequence ID" value="ARF82361"/>
        <property type="gene ID" value="B6264_28905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36348">
        <property type="protein sequence ID" value="OEV36348"/>
        <property type="gene ID" value="HS99_0029750"/>
    </dbReference>
    <dbReference type="OMA" id="YGIVLWH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="36616" checksum="E0B95BF4C5E6F33E" modified="2017-01-18" version="1">MTEPRSRRPPRHRRRGHLIGGYGLPALAVLLFLIFSVARPDTFPTLDNVSSILSNQSIPAILALGATIPIASGNFDLSIGYALGLAHIAVLRLVVDGDWPWPLACLAVILGGAAFGALNGVIVEFGRIDSFIATLGTGSILYAFTGWITGGARVLPGPGGLPAAFTDLYDSTFLGLPVSASYVLALAAVLWLLQERLPLGRYLYVIGSNPRAAELVGIPTRRYSVYAFAGSGLVVGFAGVLLAAQQQIGNPSVGLEYLLPAFVGALLGSTAIRPGRANALGTVVAVAVLAIGLAGIGQLGADFWAVPLFNGATLLLAVGLAGYSARRRLRAAGAETRGPVTPPSTDVTASRDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6U8</accession>
    <name>A0A1E7N6U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7794"/>
    <dbReference type="EnsemblBacteria" id="ARF82275">
        <property type="protein sequence ID" value="ARF82275"/>
        <property type="gene ID" value="B6264_28420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36422">
        <property type="protein sequence ID" value="OEV36422"/>
        <property type="gene ID" value="HS99_0029195"/>
    </dbReference>
    <dbReference type="OMA" id="HLEEWIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22078" checksum="40A310345FF1954F" modified="2017-01-18" version="1">MAARIDRLVTAGTFELDGGSWEVENNVWIVGDDEEAVVIDAAHDADAIEAALGGRRLLAIVSTHAHNDHIDAAPALAERTGAPILLHPDDLPLWKLTHPERLPDGELTDGRRIEVAGTELTVLHTPGHAPGAVCLYAPGLGTVFTGDTLFQGGPGATGRSFSHFPTIIDSIRERLLSLPADTVVRTGHGDPTTIGAEAPALPEWIARGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V4</accession>
    <name>A0A1E7N6V4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4905"/>
    <dbReference type="EnsemblBacteria" id="OEV36408">
        <property type="protein sequence ID" value="OEV36408"/>
        <property type="gene ID" value="HS99_0029715"/>
    </dbReference>
    <dbReference type="OMA" id="YAATDQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="17923" checksum="131A6333AB543B98" modified="2017-01-18" version="1">MIIRHGEKPDGSHPGLDENGKHDDKSLTQRGWDRAKTLPTLFAPPAAGLRTPVRIYAATDQGPMAGAHRMRQTVTPLGAELGLTVDTTYAESQESELAGAALAGAQPVLICWEHSRIPRIVEALGASGSGVPASWPDRFDLAWVFSRPAGGAWTFQEVHQHLLEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N700</accession>
    <name>A0A1E7N700_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_1_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene236"/>
    <dbReference type="EnsemblBacteria" id="OEV36477">
        <property type="protein sequence ID" value="OEV36477"/>
        <property type="gene ID" value="HS99_0029260"/>
    </dbReference>
    <dbReference type="OMA" id="FDGYPIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="37742" checksum="F556A045585D6BE8" modified="2017-01-18" version="1">MALRPAGRLMAGDSGARHLLAQNEHPYPPLPSVLTALAGAASDLNRYPDLRPERFAGLIADWQSVPAAQVVVGHGSAGVALDLFHSVVRPGDNVVHSAPCFDAYPLFCRIAGAEARAVPLGPDARHDLAAMAGQLDERTRIVVLCNPHNPTGTVYSWAELTDFLRRVPATALVLLDEAYIDFARGWEAPDVPARIAEWPNLVVLRTLSKSHGLAALRIGYAVAEEAVAQRVRDHQVPYAVNRLQEAGLLAAVAAQEEVDRRIAEIAGERERLRAELLALGRSVPPSLTNFLWVSAPGDETPVRRELERLGVAVRFYPGQGIRIAVGEKDANDAVIEGFTRAHRAVAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N706</accession>
    <name>A0A1E7N706_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8111"/>
    <dbReference type="EnsemblBacteria" id="OEV36243">
        <property type="protein sequence ID" value="OEV36243"/>
        <property type="gene ID" value="HS99_0030445"/>
    </dbReference>
    <dbReference type="OMA" id="GEPEWIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="130"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="28892" checksum="91CCE2F9D808AFA5" modified="2017-01-18" version="1">MIGTGRVGPALGAALQLAGHTVVAASGVSAASRRRADALLPGVRIVTPPQVMAAADLVLLTVPDDALADLVSGLAATGAVRPGQLLVHTSGAHGVGILEPATRAGALPLALHPAMTFTGTSVDLARLAGCPFGVTAPEELRPVAEALVVEMGGEPEWVPEEVRPLYHTALAHGANHLVTLVAQAVELLRTAGVAEPGRMLGPLLGAALDNSLRSGDAALTGPVARGDAGTVRRHLAQLSTVSPDIPAAYRAMARATAQRALANGTIDDASAAALLDVLNEESGNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N794</accession>
    <name>A0A1E7N794_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289675.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79136">
        <property type="protein sequence ID" value="ARF79136"/>
        <property type="gene ID" value="B6264_09585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36560">
        <property type="protein sequence ID" value="OEV36560"/>
        <property type="gene ID" value="HS99_0029000"/>
    </dbReference>
    <dbReference type="OMA" id="MKEAKGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="8122" checksum="DFE8952874336214" modified="2017-01-18" version="1">MKTSKRVLTALALMGTAFAATASSAGSAYALAGIGEGPGGLLAAPGFLFADTVTGGSLPVGQSQIGSLADQAVKDRMKEAKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A8</accession>
    <name>A0A1E7N7A8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7892"/>
    <dbReference type="EnsemblBacteria" id="OEV36559">
        <property type="protein sequence ID" value="OEV36559"/>
        <property type="gene ID" value="HS99_0028995"/>
    </dbReference>
    <dbReference type="OMA" id="KVGRFPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198929" description="DUF11 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="333"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="46630" checksum="C152CB93E55AAE18" modified="2017-01-18" version="1">MRVRALAVGLALTAGLALPVLAPSPAMAATGQQGYVDNIGANTVTVFNTATNTVTTTIPVGAQPADVKVTPNGQHAYVVNRSSGTVSVIDTATNTVTTTIPLPAGDHPQALAITPNGLHAYAANFNGTVSVIDTTTNTVTTDIPLPSGSDPRFIATTPDSLHAYVTELGLGQVQVIDTTSNTITATIPGFTQPSGITITPDGLHAYVDDFATNSVSVIDTATNTVVGSPIPVGNAPYGNAVTPDGHQVYVGNVSDGTVSVIDTTSNTVTTTVTVGTSPYKLGMNPDGKHVYVGNFSSNTVSVIDTTTNMVSATFAVTGPFGIAITPVVAAPSLTITKTHTGTFTPGRTGTYTITVGNNGTAPTDGTTVTVKDTLPAGLTATSITGRGWRCVQRTLTCTRSNVLNPGNTYPPITLRVRVARTATGTLTNTATVSGGGDGTATATDPTVIDPRDDHHQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F6</accession>
    <name>A0A1E7N7F6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280614.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000524.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7779"/>
    <dbReference type="EnsemblBacteria" id="OEV36626">
        <property type="protein sequence ID" value="OEV36626"/>
        <property type="gene ID" value="HS99_0028015"/>
    </dbReference>
    <dbReference type="OMA" id="ERIAWVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15929" checksum="42AA9ED4EAE576BC" modified="2017-01-18" version="1">MGRIEESVEVAAPLGEVYRHWVHCEDFPQFMRGVVSVDVSGRGSSSWVVETAGGRREFEAVTTEVVEGERVAWDGGSGPVRHSGVVTFHHVDDRTTRVMLQLEVEPPGLWAHLAEALGFVDRRVIDDLNDFKHHVERSSGLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L5</accession>
    <name>A0A1E7N7L5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2468"/>
    <dbReference type="EnsemblBacteria" id="ARF81527">
        <property type="protein sequence ID" value="ARF81527"/>
        <property type="gene ID" value="B6264_23770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36697">
        <property type="protein sequence ID" value="OEV36697"/>
        <property type="gene ID" value="HS99_0028485"/>
    </dbReference>
    <dbReference type="OMA" id="HEAHVEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15638" checksum="C1EBC4E8A4BC2906" modified="2017-01-18" version="1">MPPPHLPTTQSAVLAIEAVAARHGRAVRAQHDVGSDRTFAGLVGHEDGPDAIPHEALLEFDGSPRTAVRLFTHDEVTVTVEGIPFDVPRDSVPAFLNSVWSGLVHVRARTFPPSTTLIVTVPGEAGYRESLGLHDLTPWLSGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V8</accession>
    <name>A0A1E7N7V8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36758">
        <property type="protein sequence ID" value="OEV36758"/>
        <property type="gene ID" value="HS99_0027480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="7646" checksum="C1554ACAD99A7F1A" modified="2017-01-18" version="1">MTMSFLASIRSFVRDGGDHGGRGGYGFDDFTRHGGDHGGRGGYGFDDFMRHGGDHGGDYGDDYGDYGDWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N854</accession>
    <name>A0A1E7N854_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282004.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6463"/>
    <dbReference type="EnsemblBacteria" id="ARF78673">
        <property type="protein sequence ID" value="ARF78673"/>
        <property type="gene ID" value="B6264_06875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36880">
        <property type="protein sequence ID" value="OEV36880"/>
        <property type="gene ID" value="HS99_0026810"/>
    </dbReference>
    <dbReference type="OMA" id="LHLETQT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="34593" checksum="A73270868F31E7C5" modified="2017-01-18" version="1">MSDSHSPHGFDLVRRGYERAQVDERITKLVADRDSALTRISALEKRIEELHLETQTAQAAVAEQEPSYAGLGARVEKILRLAEEEAKDLRDEAHRAAEQHRELAEAAAQQVRTEAENYAKDRKAKAEDEGLRIVDKAKSDSAQLRAEANKDAQNKREEADALFEETRTKAAQAALEFETNLAKRREQSERDLAARQAKAEKRLAEIEHRAEQLRLEAEKLRTDAERRARQTVETAQRQSEDIVADANAKADRIRSESERELAALTNRRDSINAQLTNVREMLATLTGAAVAAASLPNDDTMGVPAQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8G7</accession>
    <name>A0A1E7N8G7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein CsbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557244.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene150"/>
    <dbReference type="EnsemblBacteria" id="ARF81745">
        <property type="protein sequence ID" value="ARF81745"/>
        <property type="gene ID" value="B6264_25150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36982">
        <property type="protein sequence ID" value="OEV36982"/>
        <property type="gene ID" value="HS99_0003865"/>
    </dbReference>
    <dbReference type="OMA" id="ANMKQAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="57" mass="5972" checksum="A7990EB9319B85DB" modified="2017-01-18" version="1">MSASDKIENAAEKAKGAVKESVGKVTGNERLQAEGKADKAKGDVKQAGEHVKDAFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H0</accession>
    <name>A0A1E7N8H0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene142"/>
    <dbReference type="EnsemblBacteria" id="ARF81739">
        <property type="protein sequence ID" value="ARF81739"/>
        <property type="gene ID" value="B6264_25110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36987">
        <property type="protein sequence ID" value="OEV36987"/>
        <property type="gene ID" value="HS99_0003905"/>
    </dbReference>
    <dbReference type="OMA" id="GFAFCDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="49783" checksum="D1DB138B14940710" modified="2017-01-18" version="1">MTTPRLTLDELRTRVADGSVETVVLAMTDMQGRLQGKRVAADYFLDDVVTGAAEGCGYLLAVDVDMNTVDGYEVSSWDNGYGDLTLRPDLTTLRAVPWHPATAMVQCDVVHHDGTPVAVSPRQVLRRQLDRLAGYGWQAQAATELEFIVFRDSYEQAWDKDYTRLTPANQYNVDYSILGTGRIEPLLRRLRNGMAGAGLTVESAKGECNLGQHEIAFKYADALTTCDNHAVYKTGAKEIAAQEGCSLTFMAKYDEREGNSCHIHLSLRDERGAPVFAGDRPHGFSRTMEHFLAGQLACLADFALLFAPTVNSYKRYVPGSFAPTAIAWGRDNRTCALRVVGHGPSLRFENRVPGGDVNPYLAVAALIAAGLHGVEQQLELQPEFTGNAYASDAPRVPATLRDAVDAFERSAVATEAFGKDVVRHYTHAGRTELASYERAVTDWERRRGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R3</accession>
    <name>A0A1E7N8R3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366302.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81638">
        <property type="protein sequence ID" value="ARF81638"/>
        <property type="gene ID" value="B6264_24475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37090">
        <property type="protein sequence ID" value="OEV37090"/>
        <property type="gene ID" value="HS99_0004515"/>
    </dbReference>
    <dbReference type="OMA" id="HIVHMAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16265" checksum="1D5473892C98F9AC" modified="2017-01-18" version="1">MKITITVEDPTPEALEKLLALAAMPAAVVTAVPDDRWTPERARSYYDRLPPRAQQILLQVVEGEGECAAEELKANGRNLRGSTGAFRRVLTEGKRTGLWPDALPVPLVSHIVGGQLKKLEMPGSGTDRYTYPVFAEGLRDLLPIGRDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N905</accession>
    <name>A0A1E7N905_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556641.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6211"/>
    <dbReference type="EnsemblBacteria" id="ARF81565">
        <property type="protein sequence ID" value="ARF81565"/>
        <property type="gene ID" value="B6264_24025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37169">
        <property type="protein sequence ID" value="OEV37169"/>
        <property type="gene ID" value="HS99_0004965"/>
    </dbReference>
    <dbReference type="OMA" id="WLLYAWC"/>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="36041" checksum="66761F14D2FA0734" modified="2017-01-18" version="1">MTARELDAAGVTAPALRAAYTACRDLNARHGRTYFLAARLLPVERRCAVHALYGFARWADDIVDGLDRRETPTERDRLLGLLEKDLATGLRGGGADHPVVRAVADTAGRYDIDPGLFTDFLASMRADLTVTDYPTYQDLYRYMHGSAAVIGLQMLPVLGTVTGRAEAEPYAAALGVAFQLTNFLRDVGEDLDRGRVYLPGDLLAAHGVDRPLLEWSRRTGRDDARIRAALVAAAGLARGVYRDAEPGIAMLEPRVRPCIGTAFVLYGGILDAIARDGYAVLHRRSAVPLRRRAAVAAAGLARVLAARVPAAVRGGLPSGPPHHRPAGPDGRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N935</accession>
    <name>A0A1E7N935_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37210">
        <property type="protein sequence ID" value="OEV37210"/>
        <property type="gene ID" value="HS99_0005230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="12357" checksum="74531F04F0E2965C" modified="2017-01-18" version="1">MQLSEVLHRRLERIERLLEPEKPERPAWRSVTLGEQRWAVSVAILVAVGLQLALPTRLTIRTPPNGSSSGWSPCWAGRFTALRLPADPGGRPGRPYPSARSRLNAALISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N942</accession>
    <name>A0A1E7N942_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000097_gene44"/>
    <dbReference type="EnsemblBacteria" id="OEV37215">
        <property type="protein sequence ID" value="OEV37215"/>
        <property type="gene ID" value="HS99_0005265"/>
    </dbReference>
    <dbReference type="OMA" id="QYFFAMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027283">
        <property type="entry name" value="YerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500060">
        <property type="entry name" value="UCP500060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="527" mass="56972" checksum="D483BD45893EFA03" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F1</accession>
    <name>A0A1E7N9F1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000740.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6683"/>
    <dbReference type="EnsemblBacteria" id="ARF81625">
        <property type="protein sequence ID" value="ARF81625"/>
        <property type="gene ID" value="B6264_24395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37103">
        <property type="protein sequence ID" value="OEV37103"/>
        <property type="gene ID" value="HS99_0004595"/>
    </dbReference>
    <dbReference type="OMA" id="SGTNWEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32312" checksum="7C46095C0B5FB272" modified="2017-01-18" version="1">MTSTTVPPALDTTAVVESIADLVRENYVFPDAAGQLAALLRRRSVEGAYRAESADELAEAVTTDLRSVNGDLHLALKHHAVPVPPDKGEAALAAMRREFDTSLNGVPRVELLDHGVAVLEIAPKMFPLDWAAQPLAAALSLVAPARALILDLRRNTGGDPNTVAFVCGYLLDRRTHLNTLLSRQGEVAEQFWTPPFVPGARFGGSKPLWVLTSANTFSAAEELAYDLQQLGRAEIVGEATRGGAHPREGWTVHPNLELSVPVARAVNPVSGTNWEGTGVRPDVPCDAEAALDRALSLAATRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N9</accession>
    <name>A0A1E7N9N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83058">
        <property type="protein sequence ID" value="ARF83058"/>
        <property type="gene ID" value="B6264_25200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37407">
        <property type="protein sequence ID" value="OEV37407"/>
        <property type="gene ID" value="HS99_0003815"/>
    </dbReference>
    <dbReference type="OMA" id="APNQWGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12867" checksum="2F6D9A634478F883" modified="2017-01-18" version="1">MITLNEFFDGNDNEGSIAPNQWGYGRPALAELAERLRVIEQREDVAWVRVQLHPETMEMEELAGEAVAICTTAGESVRAAWIEGLEASGTIPELVDVYRDIPAVPHGATVWSVMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9X5</accession>
    <name>A0A1E7N9X5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287112.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7949"/>
    <dbReference type="EnsemblBacteria" id="ARF79091">
        <property type="protein sequence ID" value="ARF79091"/>
        <property type="gene ID" value="B6264_09320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37482">
        <property type="protein sequence ID" value="OEV37482"/>
        <property type="gene ID" value="HS99_0026035"/>
    </dbReference>
    <dbReference type="OMA" id="KLDMQVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="350"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="541"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1337" mass="147310" checksum="C996A4933FA26E1B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA40</accession>
    <name>A0A1E7NA40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386814.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000521.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1135"/>
    <dbReference type="EnsemblBacteria" id="ARF79015">
        <property type="protein sequence ID" value="ARF79015"/>
        <property type="gene ID" value="B6264_08875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37556">
        <property type="protein sequence ID" value="OEV37556"/>
        <property type="gene ID" value="HS99_0026480"/>
    </dbReference>
    <dbReference type="OMA" id="DGPDRQK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="42266" checksum="1DA2D1BEEBC69D40" modified="2017-01-18" version="1">MTNETAVEDQLDGGVPYRSRRRTLVRAGVPVAVGAVIAAGVGLVPALAADSPPDLPQLSAEQVVTKVLGSDTQALSGTVSVSTDLGVPSQLLGAAAGGLGAAAGHGSDQGGASADPQSKLLGLLGGDQTLRVAVDGPDRQRVDLMENMAGYTLVRNGDQSWAWDSSTNTALHMTGRPAGHTGAKAPKAPLTGVPATPQEAARQFLTGSAGTTSVTVAGTANVAGQKAYQLSVKPTQSGSTVSEVRISVAADNGVPLAVVVKSTDGSTVLDVHFTDVSFAEPTAKTFDFTAPKGAKVTEKKADEAAAGHDAQDKKGDQGGKGDRGKGHDGVNVIGEGWTAVVSTQLPTGVEAPAQGSQGNGKQGKQHGRPMNPQALVKSLGKPVGGGTLISTKVVNVLLTDDGRVFAGAVTLPVLQHAAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB6</accession>
    <name>A0A1E7NAB6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="15" type="ORF">HS99_0025365</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290435.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6237"/>
    <dbReference type="EnsemblBacteria" id="OEV37637">
        <property type="protein sequence ID" value="OEV37637"/>
        <property type="gene ID" value="HS99_0025365"/>
    </dbReference>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="166"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="499"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="627"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1046"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128464" checksum="1B9E5291A34875DA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF0</accession>
    <name>A0A1E7NAF0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37463">
        <property type="protein sequence ID" value="OEV37463"/>
        <property type="gene ID" value="HS99_0006290"/>
    </dbReference>
    <dbReference type="OMA" id="FAESRPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="25489" checksum="1303F21E407A66AD" modified="2017-01-18" version="1">MVFAAGTEATMFAESRPFRVSEHRLPAWKAVLSIGGHAELLQPGLRMVAAPGLIVPPQLAHVCAATSPYIALFVDSWLLPSCPGPIRLDAGEVRRLLAALGTAGPDGPGTQVDLAAGFTELRAVAGRPTPLDPRVAHALYVCMLRDSDMPLASIAEEVGLSAPRLRTLVRQDVGITLTRLRRWGRLRTAVADLPAGAAAVAAATAGFADQAHLTRTARDFIGRTPASLRRDGATLAAPRDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG4</accession>
    <name>A0A1E7NAG4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="9" type="ORF">HS99_0025640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280788.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1666"/>
    <dbReference type="EnsemblBacteria" id="ARF79944">
        <property type="protein sequence ID" value="ARF79944"/>
        <property type="gene ID" value="B6264_14430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37687">
        <property type="protein sequence ID" value="OEV37687"/>
        <property type="gene ID" value="HS99_0025640"/>
    </dbReference>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="21142" checksum="CD9E2004BF84E14E" modified="2017-01-18" version="1">MAGPQRREGGAGRGTGGERRDRKRDGQGNAQAVEKTAYVERVVAINRVAKVVKGGRRFSFTALVVVGDGEGTVGVGYGKAKEVPAAIAKGVEEAKKNFFRVPRIQGTIPHPIQGEKAAGVVLLKPAAPGTGVIAGGPVRAVLECAGIHDILSKSLGSDNAINIVHATVAALKGLVRPEEIAARRGLPLEDVAPAALLRARAAGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL2</accession>
    <name>A0A1E7NAL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366736.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4924"/>
    <dbReference type="EnsemblBacteria" id="ARF79995">
        <property type="protein sequence ID" value="ARF79995"/>
        <property type="gene ID" value="B6264_14715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37735">
        <property type="protein sequence ID" value="OEV37735"/>
        <property type="gene ID" value="HS99_0025920"/>
    </dbReference>
    <dbReference type="OMA" id="HAVHAGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27552" checksum="060853B4E3BEB30B" modified="2017-01-18" version="1">MAPEAAARPTRAELRLAAREQSRAQRRGAAKAATRAALFRVAVPSVAALGVAGAAGVTVVHEQADRVPSQASAADAPDRTAAQQTAQQTAADLDQAAQASRGDARQPLSGAQPGDGQPTATPTAQPTAQPAKPKVVMPVAQHGLGELFGAAGTHWMNRHTGIDFPVDGGSEVYAVTDGTIRTQWNPFYGYMSILKMPDGTEAWMCHLRAYKVRKGPVKQGDVIAYVGSSGNSTGPHLHFEIRPPGSGPVDPLPWFLSNGLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN3</accession>
    <name>A0A1E7NAN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552366.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37543">
        <property type="protein sequence ID" value="OEV37543"/>
        <property type="gene ID" value="HS99_0026415"/>
    </dbReference>
    <dbReference type="OMA" id="AAEHFFC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23124" checksum="A149C7B9768827B4" modified="2017-01-18" version="1">MATTGGAGRPEKRKAITRAATTVFGREGYVRASMDAIAAEAGVSKRTVYNHFADKETLFLSVALQNSAELTERIRELMAKYLDRVVDLRRDLTDFAVERANAVLSAGEHGALGRAIRAEVANIPVDVLEAWLEAGPVASQRDLAQHFAALSGRGLLAVEDGELAAEQFTLLTFHGVAERSFWGALPVASEEVERIATAGVDAFLRIHGGPGAGRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU2</accession>
    <name>A0A1E7NAU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78060">
        <property type="protein sequence ID" value="ARF78060"/>
        <property type="gene ID" value="B6264_03230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37805">
        <property type="protein sequence ID" value="OEV37805"/>
        <property type="gene ID" value="HS99_0024765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="11607" checksum="A7E5AA43AA37E310" modified="2017-01-18" version="1">MVAGGGLADELGEAWSWCCSACSSSGSSPAVPRSSSSSRSSYLVWRSQQLWTLARRSSRRSRTGRLGSRGEEVRAGVLGVLLLVVGVLELLAQAGGVGEEAVGDGEGPGAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB10</accession>
    <name>A0A1E7NB10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737825.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2149"/>
    <dbReference type="EnsemblBacteria" id="OEV37880">
        <property type="protein sequence ID" value="OEV37880"/>
        <property type="gene ID" value="HS99_0023635"/>
    </dbReference>
    <dbReference type="OMA" id="LWWAYPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="396"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="733" mass="77352" checksum="96C399123F200AF4" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF4</accession>
    <name>A0A1E7NBF4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278389.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000105.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79543">
        <property type="protein sequence ID" value="ARF79543"/>
        <property type="gene ID" value="B6264_12000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37988">
        <property type="protein sequence ID" value="OEV37988"/>
        <property type="gene ID" value="HS99_0024320"/>
    </dbReference>
    <dbReference type="OMA" id="RLIRCPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="8015" checksum="7C2AE6622A568E60" modified="2017-01-18" version="1">MEQRTVVRCAEGHLFSTTTFPMQNLGPGRLGPGRLIRCPQCGRLRSSVLADVRELSTAQLAQAMRLEAAEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC01</accession>
    <name>A0A1E7NC01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366774.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3312"/>
    <dbReference type="EnsemblBacteria" id="OEV38220">
        <property type="protein sequence ID" value="OEV38220"/>
        <property type="gene ID" value="HS99_0021935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017557">
        <property type="entry name" value="Holo-ACP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10620">
        <property type="entry name" value="MdcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="28212" checksum="854AFF6AF7A5B174" modified="2017-01-18" version="1">MRNSAEELHNGPRRRVGPLAALDGRLPGVHDLLLLQCPSSLHPLTGGGLPDWARTVLRAHPWVTVGRAPAVVGTPVDVPRPRHCTRDPEAAPEHWLPVTVRGPRPGQRLDALAPWAAVARTLRPERLAERRARLAPERITDIPALALLPEAGRLVADHRLAWGPIGAVGYELGTGVPVAGPLSPLRLVLRAPHPISRRDALQLRRALSKLPVPVQAELETRYGAVQLAEYAAGVHTFTLLTPYGPREVHDPWFPRGPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC38</accession>
    <name>A0A1E7NC38_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0021925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3310"/>
    <dbReference type="EnsemblBacteria" id="OEV38218">
        <property type="protein sequence ID" value="OEV38218"/>
        <property type="gene ID" value="HS99_0021925"/>
    </dbReference>
    <dbReference type="OMA" id="WLRWPIS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="829"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1051"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="952"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1011"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1075" mass="116107" checksum="F3BAA897618E0886" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC44</accession>
    <name>A0A1E7NC44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290707.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1737"/>
    <dbReference type="EnsemblBacteria" id="ARF80226">
        <property type="protein sequence ID" value="ARF80226"/>
        <property type="gene ID" value="B6264_16080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38257">
        <property type="protein sequence ID" value="OEV38257"/>
        <property type="gene ID" value="HS99_0022200"/>
    </dbReference>
    <dbReference type="OMA" id="CGLVWCK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20262" checksum="8E9D7319E51041DC" modified="2017-01-18" version="1">MSTIIRRVRTDEWERVKEIRLAALQDPVAHLAFLDTYENASAKPDGFWQERTAGAAEGESVWQAVAEAPDGRWLGTMTVLVERPGGNGALGGDVITVPQAHVVGVYVRPEARGTGLAHELIEAAQDWAWSLSEPRLRRVRLFVHESNARAEAMYVRAGFKPSGASVPVPGDETHREIELAVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR1</accession>
    <name>A0A1E7NCR1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287761.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000832.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene324"/>
    <dbReference type="EnsemblBacteria" id="ARF82156">
        <property type="protein sequence ID" value="ARF82156"/>
        <property type="gene ID" value="B6264_27710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38448">
        <property type="protein sequence ID" value="OEV38448"/>
        <property type="gene ID" value="HS99_0021340"/>
    </dbReference>
    <dbReference type="OMA" id="HEFRFAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046179">
        <property type="entry name" value="DUF6188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19686">
        <property type="entry name" value="DUF6188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="13484" checksum="1992A502FB1CE0C3" modified="2017-01-18" version="1">MQNAITEVLTGRRVEAVNGGGGLALRLDGPVTVRVAHEFRFAAPSFAAPSEVEHFFPALTVRPTPSLLALVGRTVGAARVTPAGGLELGFAEGGALSVPPHALVAPWSVLTPEGAVCAGLPGGEVRWTEPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX8</accession>
    <name>A0A1E7NCX8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281341.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000526.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene697"/>
    <dbReference type="EnsemblBacteria" id="ARF77572">
        <property type="protein sequence ID" value="ARF77572"/>
        <property type="gene ID" value="B6264_00315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38549">
        <property type="protein sequence ID" value="OEV38549"/>
        <property type="gene ID" value="HS99_0019900"/>
    </dbReference>
    <dbReference type="OMA" id="RPDAWWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="2">
        <location>
            <begin position="140"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="33963" checksum="75AFCF693B30BC40" modified="2017-01-18" version="1">MTALIGLLLLGLLLSTVVPRLLARARWVEREPVLALLVWQCIVVAVLLCCALGLLLAASAAEPELRAWVFSGAPHGVEDAYGLQDAEGWGRLCAAVLAAGALQTVRALTREVRTAKALRNRRHAQLATRAPELPEAIESARSRRERLVVLENVRPEAWSLPGPNSRLVVTTGALQQLTDRELAAVLSHERGHVRARHHWLQQFAQALASGFPGIGVFRAFRDQVAELVELAADDRAARRHGRHTTALALAELNLDRGVFGSCPPGLAQSPKRVDRLLAGRPRLSVPQRLRLTAVALAAPVGAVLLAVAPGLHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN0</accession>
    <name>A0A1E7NDN0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287331.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000266.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6268"/>
    <dbReference type="EnsemblBacteria" id="ARF81221">
        <property type="protein sequence ID" value="ARF81221"/>
        <property type="gene ID" value="B6264_22040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38816">
        <property type="protein sequence ID" value="OEV38816"/>
        <property type="gene ID" value="HS99_0019305"/>
    </dbReference>
    <dbReference type="OMA" id="RKIERKC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="80"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="19700" checksum="B4545A76FA9B468E" modified="2017-01-18" version="1">MLVTLTGGAGAGKTTLAAALAAAAGPGGRVRVLHGDDYYYAEPGRGGVWAPDEAGVPRLDVGDPRSVDAGRLADDIDAALGEARVVVVDGLFARTVAPRRPCARLDVFVDLPADLRLARKIERKCVAGGFPLAVLLRNYVGHRRAAHERHVEPLRARCDLVVDGALAPEALAGQVWAAAAARDGQGRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN9</accession>
    <name>A0A1E7NDN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737785.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6259"/>
    <dbReference type="EnsemblBacteria" id="ARF82996">
        <property type="protein sequence ID" value="ARF82996"/>
        <property type="gene ID" value="B6264_21990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38807">
        <property type="protein sequence ID" value="OEV38807"/>
        <property type="gene ID" value="HS99_0019255"/>
    </dbReference>
    <dbReference type="OMA" id="CHLTGHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="12811" checksum="EB983DF8AFEC7311" modified="2017-01-18" version="1">MTAPNSVTPDLTVDGTGLLCVQLLLRLRAQIADLPAGAVVHIHTTDPAAPLDLPAWCHLTGHEYLGPVPSPAPDREVYALRLTSAPVRTRPGRPWHPDPTPTPTPAPTTTPPTPTPTEDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDY9</accession>
    <name>A0A1E7NDY9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0019485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5131"/>
    <dbReference type="EnsemblBacteria" id="ARF81252">
        <property type="protein sequence ID" value="ARF81252"/>
        <property type="gene ID" value="B6264_22220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38848">
        <property type="protein sequence ID" value="OEV38848"/>
        <property type="gene ID" value="HS99_0019485"/>
    </dbReference>
    <dbReference type="OMA" id="GVHVGTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="273"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="748" mass="83459" checksum="908EAF6D454FD8BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ5</accession>
    <name>A0A1E7NDZ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="6" type="ORF">HS99_0019160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290262.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7384"/>
    <dbReference type="EnsemblBacteria" id="ARF82994">
        <property type="protein sequence ID" value="ARF82994"/>
        <property type="gene ID" value="B6264_21895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38920">
        <property type="protein sequence ID" value="OEV38920"/>
        <property type="gene ID" value="HS99_0019160"/>
    </dbReference>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="45535" checksum="295F8489F2A9DC03" modified="2017-01-18" version="1">MIRNAKILGGAPQDLHLADGVIRAIGTGLAVEADIEIDATGMIVLPGLVDLHTHLREPGREDAETVLTGTQAAAMGGFTAVHAMANTTPVADTAGVVEQVWRLGQEAGYCDVQPVGAVTVGLEGKKLAELGAMHESAANVRVFSDDGKCVDDAVLMRRALEYVKAFDGVVAQHAQEPRLTEGAQMNEGQVSGELGLGGWPAVAEESIIARDVLLAAHVGSRLHVCHLSTAGSVEIVRWAKSKGWDVTAEVTPHHLLLTDEMVRSYDPVYKVNPPLRTAEDVQALRKALADGTIDAVATDHAPHPAEDKDCEWAVAAMGMVGLETALSVVQQTMVDTGLLNWEGVADRMSHRPARIGRLSGHGRPVSVGEPANLVLFDPAYRGAVNPDSFATRSRNTPYKGMDLPGRVHATFLRGRATVLAGELAEQGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEK9</accession>
    <name>A0A1E7NEK9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0018645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4096"/>
    <dbReference type="EnsemblBacteria" id="OEV39104">
        <property type="protein sequence ID" value="OEV39104"/>
        <property type="gene ID" value="HS99_0018645"/>
    </dbReference>
    <dbReference type="OMA" id="IVAPWGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="40997" checksum="EE5695B5423BFFBF" modified="2017-01-18" version="1">MTSTAQKEGRPCPGRPARTWDAAFTAVPRSLFLPDLMWAHDLATNTSRAVSRTSDPDGWAAAAAADIPIVTQWDDGRHHGEQPGSVPTSSASQPSVVAAMLEHLDVQAGQRVLEVGTGTGWNSALLSHRLGDANVVTVEIDPDVTARARTALHKAGYRPTVVCGDGAAGWAPGAPYDRIVATCALREVPHAWIRQARPGALILTPWGTHYSNLDALLRLEVDDDGTTASGRLLEPVEFMKLRSQRLTWPTPPANGGTLTESSTATTPPEHGRHAAFTFLMGLLLDGVTHAVQPHDDGARTLWLYSLTEPAWSATTFREGEREHQVRQYGARRLWEEFETAYAWWTAAGQPGLARFGLTVTPDGQHLWLDDPTRPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF06</accession>
    <name>A0A1E7NF06_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0000425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550170.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3548"/>
    <dbReference type="EnsemblBacteria" id="OEV39228">
        <property type="protein sequence ID" value="OEV39228"/>
        <property type="gene ID" value="HS99_0000425"/>
    </dbReference>
    <dbReference type="OMA" id="YDLLCPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="35289" checksum="BA06DEF272C0CEB8" modified="2017-01-18" version="1">MPEPYRHDEPYAQGLLDVGDGQRIHWNTSGDPAGKPAVVVHGGPGSGHNPGSRRYFDPRRYRIVQYDQRGCGRSLPHAADPSTGLEHNTTAHLVADLERLREHLGIDKWLLYGGSWGSTLILAYAEAHPERVSGIVVCGVTMTRPEELEWLYQGVGRFLPGPWEEFRDFLPAADRDGDVFDLLAAYSRQLNSPEESVRRAAARAWATWEDAVISHEVLGKPNAYSDRPSDALMAFTRITAHYFSHRAFLADGQLLSNAGRLAGIPGELIHGRLDLGGPLHTPWQLAKAWPDARLTVIDEAGHTGSPRMAEALLAAVERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF73</accession>
    <name>A0A1E7NF73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288915.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1505"/>
    <dbReference type="EnsemblBacteria" id="OEV39337">
        <property type="protein sequence ID" value="OEV39337"/>
        <property type="gene ID" value="HS99_0001085"/>
    </dbReference>
    <dbReference type="OMA" id="RFVWELR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15952" checksum="696660DFFA42F84A" modified="2017-01-18" version="1">MTNPTGHEIAEALGLLLRRSTRAGLHAQLTEGLGEAVDELTYPVLSGLARTGPCSAADLGREVGLDRTTVTRRADRLEEAGLLRREADPGDRRATLLVLTDAGQGVVRTTRERLAARIEDSLASWPAADARAFARLLRVFVDEGPFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY2</accession>
    <name>A0A1E7NFY2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385404.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2740"/>
    <dbReference type="EnsemblBacteria" id="OEV39606">
        <property type="protein sequence ID" value="OEV39606"/>
        <property type="gene ID" value="HS99_0002730"/>
    </dbReference>
    <dbReference type="OMA" id="NAMDSVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="36422" checksum="F55C5AA9B4577A20" modified="2017-01-18" version="1">MSVLDGLDDYQRRHRWAGLTIAVVYKFIDDQGTYMAALITYYGFLSLFPMLLLLVAVLGFALHGDAQLQQQVLHSALSQFPVIGDQIEHNIRSFQGSGFALAVGIAGSLYGALGVAQALQNAFNTVWAVPQHSRPNALTARLRGLALLGVLAVAVMASTVLAALTATAHGWPAWIDRCVRIAAVPLSVAVGTALLLAGFKLLTNSRLRVRLLWPEALAASLTWQALLLVGTYYVGHELRGATATYGLFGMVLGLMAWIYLGALTLVVCAESAAVRTRGLWPRGITAPFADHAPLTRADRRAYTSYATAAAYKPDEEIRVDFPPPGAQRGDGGRPPSPADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG45</accession>
    <name>A0A1E7NG45_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2830"/>
    <dbReference type="EnsemblBacteria" id="OEV39680">
        <property type="protein sequence ID" value="OEV39680"/>
        <property type="gene ID" value="HS99_0003180"/>
    </dbReference>
    <dbReference type="OMA" id="GFQTFRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28688" checksum="660C6F132439F48D" modified="2017-01-18" version="1">MILSRRTRIALRAAMVAGLAVVYLPLLLVLLNSLNRDRSFAWPPAGLTTQWWVRAWQSEGARSAVLTSLQAGAGATLVALVLGTMTAFAVQRHRFFGRQTVSFLVILPIALPGIVTGIALNAAFRTVLGPAGIGFGLLTVVIGHATFCIVVVFNNVVARLRRTFPSAEEASADLGAHTFQTFRYVTFPAVRSALLAGGLLAFALSFDEIVVTTFTAGPGVQTLPVWIYANLARPNQAPVVNVVAAVLVLLSVVPVYLAQRLSADSPGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG0</accession>
    <name>A0A1E7NGG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3587"/>
    <dbReference type="EnsemblBacteria" id="OEV39799">
        <property type="protein sequence ID" value="OEV39799"/>
        <property type="gene ID" value="HS99_0000610"/>
    </dbReference>
    <dbReference type="OMA" id="TAPYHHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21250" checksum="0ECB25FE1A40A37D" modified="2017-01-18" version="1">MTAPPSEQDGDLRARLVAAGVELVTREGVHALGLREIARHAGVSHGAPRRHFPTHRELLAAVARQGFGRLTDLLAGADALAVTTGGDARTRIEALARAYLGFAAANPRMFELMFRHDLLEGSGSELRRTTLPLFLTFVGLVAEVHPWCDDPTAATAALWANLHGLAQLRASGSLRLATGSDGLDSLLRTSLDAHLGPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH49</accession>
    <name>A0A1E7NH49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3503"/>
    <dbReference type="EnsemblBacteria" id="OEV39783">
        <property type="protein sequence ID" value="OEV39783"/>
        <property type="gene ID" value="HS99_0000205"/>
    </dbReference>
    <dbReference type="OMA" id="WAFYDWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="242"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="46553" checksum="6CE05DB467A3E4AB" modified="2017-01-18" version="1">MQFGWYINDWANAAFSATVLTVFLGPYLTEVAKNAADASGNVHPLGLTIRAGSFFPYTVSFSVLISVAVMLLTGTVADRTGRHKELMCGFAYVGALATMGMFLLHGDRYLLGGALLVVANIAYAVSVALSYAYLPGLAAPDERDAVSSKGWAYGYAGGGLLLIANLALFQGHDALGLSSGTAVRICLVSAGLWWALFTIVPMLRLPSRAGVVRERTAAAADRPAAGSLRELGRTLKGMRRHPLTLLYLAAFLCYNDGIQTVVSQASLYGSEELGMEQTSLVVAVLMVQIVAIGGALLLGRIAHRYGAKKTILGSLVGWVVTLALGYSMPAHQPVWFYALACMIGLVLGGSQALSRSLFSHLIPAGREAEYFSVYKVSDRGTSWMGPLVFGLAYQVTGSYRSAIISLLIFFVIGFAVLVKVPVRRAIEAVGNPVPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG4</accession>
    <name>A0A1E7MVG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558308.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000971.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000107_gene5831"/>
    <dbReference type="EnsemblBacteria" id="OEV32415">
        <property type="protein sequence ID" value="OEV32415"/>
        <property type="gene ID" value="HS99_0017140"/>
    </dbReference>
    <dbReference type="OMA" id="WSYGAHN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198466" evidence="1">
        <location>
            <begin position="29"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="12592" checksum="86FFCE7829CA47AA" modified="2017-01-18" version="1">MRRTTHALAALTVAAAALTAVATGNAGAADGSWAGCPYGAVCVYPQDQNPASSPSAVYWSYGAHNLNGQYGNHWVLNNQSAGAHAHLCQSYNGANCVYDIPAQNGVYYNLGPINSITLDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG9</accession>
    <name>A0A1E7MVG9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558306.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000721.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32418">
        <property type="protein sequence ID" value="OEV32418"/>
        <property type="gene ID" value="HS99_0017155"/>
    </dbReference>
    <dbReference type="OMA" id="ERYLAMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="18085" checksum="13AA1B873440C6C8" modified="2017-01-18" version="1">MTTSLTLAPWSEPGLDLLHRQNTPELTEHLGGVESAEQVRRRHERYLAMTDGQMFLLLLGGRAAGSVGYWPHTWQEQDVYETGYAVLPEYQGRGLAVQAVLLCAQRAAQQGVLPWLHAFPSAAHQASNAVCRRAGFELLGEVAFEYPPGHPIRSNNWRLPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI6</accession>
    <name>A0A1E7MVI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290550.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1175"/>
    <dbReference type="EnsemblBacteria" id="OEV32434">
        <property type="protein sequence ID" value="OEV32434"/>
        <property type="gene ID" value="HS99_0017265"/>
    </dbReference>
    <dbReference type="OMA" id="LRLAIMS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="12370" checksum="24FBC397C83A91AF" modified="2017-01-18" version="1">MNAEPPAPAFDELIHQPTRLTVVAFLSGCAEAEFRTVRENCGVSESALSKVVSTLEAASYVKVRRGYVGKRPRTWLRLSPEGRRALAAHLAELQRIAATATALAATLDHHPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVJ4</accession>
    <name>A0A1E7MVJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290579.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1197"/>
    <dbReference type="EnsemblBacteria" id="OEV32450">
        <property type="protein sequence ID" value="OEV32450"/>
        <property type="gene ID" value="HS99_0017365"/>
    </dbReference>
    <dbReference type="OMA" id="WARGWMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11903" checksum="37F6EB539052BD2A" modified="2017-01-18" version="1">MDENDALKTTLLVDDVEPVEVGPGILRRRLTATGYARAWLIDFEPGSRWPEVDVHDTEERYYVLSGEVIEGEERHPAGSYVVFAPGSRHRPRTEAGARILGITLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP5</accession>
    <name>A0A1E7MVP5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000679.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6298"/>
    <dbReference type="EnsemblBacteria" id="OEV32494">
        <property type="protein sequence ID" value="OEV32494"/>
        <property type="gene ID" value="HS99_0017605"/>
    </dbReference>
    <dbReference type="OMA" id="ADTHVPK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="19374" checksum="DBEB5F5F6D7EDF57" modified="2017-01-18" version="1">MPSDSFARLLLTSDTHVPTRARSLPAPLLRALDEADVVFHAGDWVDTATLDLFEARARWLVAVHGNNDGQELRERLPEVARAELAGLRFAVVHETGPARGREQRCRSRFPDTDVLVFGHSHIPWDSRAPGGPRLLNPGSPTDRRRQPFATYLTARADDGHLTELRLHRLPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVQ3</accession>
    <name>A0A1E7MVQ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000687.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2993"/>
    <dbReference type="EnsemblBacteria" id="OEV32505">
        <property type="protein sequence ID" value="OEV32505"/>
        <property type="gene ID" value="HS99_0016355"/>
    </dbReference>
    <dbReference type="OMA" id="VVATMFQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="36598" checksum="F4AE9FDB36CD02D2" modified="2017-01-18" version="1">MGIESRPVTLRVIADQLGLDVSTVSRVLNGRDGEGRRAASGPTARRVRDLAEELGYRRNPAAVSLRTRRSNLIGVVFARLSEVVVATIYEGIEEEAARHGLAAFVTNTQDDPARQRERIAMVLGRRVDGLIIGDAHLDGAALADPALRGTPHVLVNRRTEGDLPAVTCDDYQGGRLVAEHFLRLGHTRVGCVAGEPFASTGTDRTAGFVDRYAEAGLPVPAALVRHCAFDTTGGRAAATALLGAATGRPTALFAVNDLAAIGVLGAARDLGLRPGRDLALAGFNDTPVAAELPVALTTVRSPMAEQGRAAVRELLRRMGGRQARSRRLAPELVARASSGRPVGPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR3</accession>
    <name>A0A1E7MVR3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PqqA peptide cyclase</fullName>
            <ecNumber evidence="7">1.21.98.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coenzyme PQQ synthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pqqE</name>
        <name evidence="9" type="ORF">HS99_0016645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:56836"/>
            <dbReference type="Rhea" id="RHEA-COMP:14800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:141026"/>
            <dbReference type="ChEBI" id="CHEBI:141027"/>
            <dbReference type="EC" id="1.21.98.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PqqD. The interaction is necessary for activity of PqqE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. PqqE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.4" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6918"/>
    <dbReference type="EnsemblBacteria" id="OEV32514">
        <property type="protein sequence ID" value="OEV32514"/>
        <property type="gene ID" value="HS99_0016645"/>
    </dbReference>
    <dbReference type="OMA" id="QLMPTRE"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009975">
        <property type="term" value="F:cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00660">
        <property type="entry name" value="PqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011843">
        <property type="entry name" value="PQQ_synth_PqqE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00280">
        <property type="entry name" value="coenzyme_PQQ_synthesis_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02109">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="15"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="39247" checksum="0802E717CCDE899A" modified="2017-01-18" version="1">MPATAAAPPGGAVRTPAPLGLIAELTYRCPLQCTYCANPVELARYRAELDTDQWLAVIDQARGLGVLQLHLTGGEPLLRRDVTQLIARAAESGLYTNLITSGVPLAAGRARELAAAGLDHVQLSLQDAEPRPADAVAGIAAHDRKLAAARQFTSAGLPLTVNAVLHRGNLARLGALTDRAVELGADRVELAHVQYYGWARRNRAHLAPGEEQVRQAERDVAAARQRHRGRAEIVYVPADLHGGTVKPCMNGWGREQLAVTPTGGVLPCLAAAQLPGLEVPNAVTDGLAASWHDSTAFNRFRGTDWMPEPCRGCALRELDHGGCRCQAYQFTGDPAATDPACRLSPHHHLVTDPVPAETAAPVPRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW68</accession>
    <name>A0A1E7MW68_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">whiA</name>
        <name evidence="2" type="ORF">HS99_0015545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3173"/>
    <dbReference type="EnsemblBacteria" id="ARF78280">
        <property type="protein sequence ID" value="ARF78280"/>
        <property type="gene ID" value="B6264_04540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32682">
        <property type="protein sequence ID" value="OEV32682"/>
        <property type="gene ID" value="HS99_0015545"/>
    </dbReference>
    <dbReference type="OMA" id="CDAEAAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="34656" checksum="9D384D2D9A245EA6" modified="2017-01-18" version="1">MAMTPAVKDEISRLPVTRACCRKAEVSAILRFAGGLHIVSGRIVIEAELDTGAAARRLRKDLLEIFGHSSDLVVMAPGGLRRGSRFVVRVVKDGELLARQTGLVDGRGRPIRGLPPAVVSGATCDAEAAWRGAFLAHGSLTEPGRSSSLEITCPGSEAALALVGAARRLGIPAKAREVRGVDRVVIRDGDAIGALLTRLGAHESVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAGARVARALEILGEEVPEHLAAAGQLRMQHKQASLEELGALADPPLTKDAVAGRIRRLLAMADKRAAELGLPSTEANLTDEMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF4</accession>
    <name>A0A1E7MWF4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6094"/>
    <dbReference type="EnsemblBacteria" id="ARF78182">
        <property type="protein sequence ID" value="ARF78182"/>
        <property type="gene ID" value="B6264_03955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32772">
        <property type="protein sequence ID" value="OEV32772"/>
        <property type="gene ID" value="HS99_0016125"/>
    </dbReference>
    <dbReference type="OMA" id="HWKLQAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014488">
        <property type="entry name" value="UCP017371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017371">
        <property type="entry name" value="UCP017371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15970" checksum="65F009B0E2F5EBF1" modified="2017-01-18" version="1">MGQVQATTERVYDAAPERVYEALADYQVTRPKLLPAQYSEYEVRVGGTGAGTQVHWKLQATEKRVRDCLFTVSAPKPDQLVEKDANSSMVITWTVAAAGEGRSKVTVTATWQGATGIGGFFERTFAPKGLNRIHDQVLANLAAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ1</accession>
    <name>A0A1E7MWJ1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0015710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7864"/>
    <dbReference type="EnsemblBacteria" id="OEV32800">
        <property type="protein sequence ID" value="OEV32800"/>
        <property type="gene ID" value="HS99_0015710"/>
    </dbReference>
    <dbReference type="OMA" id="WASRFTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="42408" checksum="1F0BA8E110EC8BF9" modified="2017-01-18" version="1">MELAPRAQLQLAAISRWNALRGVRVGLVAAALLFMLIGANLATPIYPLLQQRLGLGPLDTTILFTIYVFALVPVLAVVGHWSDHLGRRALILPAVALAAAGDVVFATSGSFWQLALGRAVQGIAVGLSTGAAGAALGDLLPGHPTLAAKLTLACSAGGVALGPVVGALLSGGQDPLMTPFLLHAIALLALCVPLALVHPRMPGRNRPPASPPRITTPAHLRPQRLRLPRTGRREFLLASSAGFISYAVFGVYLSLAPAFAAKLLHTPSHLVGAIVAALLLGSSAAAQLIVPPTSDRLVISLGMTGLAAGLALVVAAGYTGTPALLFIGSVLGGACQGVAFRSLFTTAVAAMNPERRGSEMSSLWIIVYLGSSLPIVAVGALVKSYGLLPAVSGFATVAALLCAALAVAVARKPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV3</accession>
    <name>A0A1E7MWV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide exchange factor GrpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555491.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6553"/>
    <dbReference type="EnsemblBacteria" id="ARF81321">
        <property type="protein sequence ID" value="ARF81321"/>
        <property type="gene ID" value="B6264_22600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32911">
        <property type="protein sequence ID" value="OEV32911"/>
        <property type="gene ID" value="HS99_0013585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="28081" checksum="194BC13127C6E301" modified="2017-01-18" version="1">MTDAPTASVLDGHRPLEVPPGVESVDLEAKFTQLLFRASLLGNKLTEQKQQARAAQRELLGVLVEVDDALAALGLDRELVAHGRGAGLEATRRRLLGRLAKAGVKPMRLEGLAADPALTEIVGTEVRPGVAPETVVQTVVTGFFWEQEVLRRAQVVVAAPESALRSAEDPRVELIEPQQPEQAEKPQRPEQTEKPEQAEKPKQAEHLEEPEKPGEPEAAEPGPAPAEPAAAEAPARPVPPRARRQAKAPGRPAKRAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY51</accession>
    <name>A0A1E7MY51_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoprenyl transferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290779.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000590.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4028"/>
    <dbReference type="EnsemblBacteria" id="ARF80469">
        <property type="protein sequence ID" value="ARF80469"/>
        <property type="gene ID" value="B6264_17525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33367">
        <property type="protein sequence ID" value="OEV33367"/>
        <property type="gene ID" value="HS99_0012295"/>
    </dbReference>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="31548" checksum="0BB2DA8A73784468" modified="2017-01-18" version="1">MAARRLFGGGKQRNYVPPTPHPSGAQPPKIPGELVPEHVAIVMDGNGRWAKERGLPRTEGHKVGESVVLDVLKGAIELGVKNISLYAFSTENWKRSPDEVKFLMNFNRDVIARRRDEMDAMGVRIRWAGRMPKLWKSVVQELQVAEEQTKGNDAVTLYMCVNYGGRAELADAAQAIARDVAAGKLDPKKVNEKTLARYMYHPDMPDVDLFLRPSGEQRTSNFLLWQSAYAEFVFQDVLWPDFDRRDLWRACELFAMRDRRFGGAIPNELPAPGVLPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ0</accession>
    <name>A0A1E7MYZ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286415.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1091"/>
    <dbReference type="EnsemblBacteria" id="ARF78976">
        <property type="protein sequence ID" value="ARF78976"/>
        <property type="gene ID" value="B6264_08650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33644">
        <property type="protein sequence ID" value="OEV33644"/>
        <property type="gene ID" value="HS99_0038575"/>
    </dbReference>
    <dbReference type="OMA" id="HATMNDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="629" mass="66055" checksum="8A8F9D2825AE6F71" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ17</accession>
    <name>A0A1E7MZ17_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4946"/>
    <dbReference type="EnsemblBacteria" id="ARF80013">
        <property type="protein sequence ID" value="ARF80013"/>
        <property type="gene ID" value="B6264_14825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33676">
        <property type="protein sequence ID" value="OEV33676"/>
        <property type="gene ID" value="HS99_0038495"/>
    </dbReference>
    <dbReference type="OMA" id="FELYLFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1190" mass="133787" checksum="920F09AEF4F9B4C9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ40</accession>
    <name>A0A1E7MZ40_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease J</fullName>
            <shortName evidence="1">RNase J</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnj</name>
        <name evidence="2" type="ORF">HS99_0038390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000169.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4285"/>
    <dbReference type="EnsemblBacteria" id="ARF80359">
        <property type="protein sequence ID" value="ARF80359"/>
        <property type="gene ID" value="B6264_16860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33697">
        <property type="protein sequence ID" value="OEV33697"/>
        <property type="gene ID" value="HS99_0038390"/>
    </dbReference>
    <dbReference type="OMA" id="EYRMLIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="373"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="561" mass="61076" checksum="F8C5261B73BAC887" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB4</accession>
    <name>A0A1E7MZB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7705"/>
    <dbReference type="EnsemblBacteria" id="OEV33761">
        <property type="protein sequence ID" value="OEV33761"/>
        <property type="gene ID" value="HS99_0038010"/>
    </dbReference>
    <dbReference type="OMA" id="SPYTAAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198571" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="16986" checksum="52B8B7793D605756" modified="2017-01-18" version="1">MTALPAPVRWLAVPVALTCTVVALVGSWSSADPAVEVPQPSGRVAGYCKALAAALPQELLGHPRRDPSPASPYVAAWGGSPRTVLRCGVDRPEELNGEHAEDWSPTVDDVTWWSQKLSDGGYRFVTTMRAAYVEVTVPAGAAQNAFDPAAALTPAVKANIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZY0</accession>
    <name>A0A1E7MZY0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553319.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3773"/>
    <dbReference type="EnsemblBacteria" id="ARF78401">
        <property type="protein sequence ID" value="ARF78401"/>
        <property type="gene ID" value="B6264_05230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33773">
        <property type="protein sequence ID" value="OEV33773"/>
        <property type="gene ID" value="HS99_0037835"/>
    </dbReference>
    <dbReference type="OMA" id="GMMHAAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="22638" checksum="1859F457DF64FB6F" modified="2017-01-18" version="1">MSREPRREQLLNAADRVIQREGPSASMNAIAAEAGITKPILYRHFGDRNGLIGALTERHTSGLLAAVRAALAEPLERRDRVEHVLDTYLAGIEARPQVYRLLTHPEPGDPSGAGNALAPALRQIAEEITHAVQSQVDLGADRDLLAEAWGRGITGMVLAAGDWWLETRPCSRTRMVQALADLLWGRLAAAADLPTAVLPAAPAEPPSAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N091</accession>
    <name>A0A1E7N091_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0011830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557268.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3703"/>
    <dbReference type="EnsemblBacteria" id="OEV34117">
        <property type="protein sequence ID" value="OEV34117"/>
        <property type="gene ID" value="HS99_0011830"/>
    </dbReference>
    <dbReference type="OMA" id="INIPMIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA" evidence="7">
        <location>
            <begin position="613"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="793" mass="84518" checksum="C483DCC76BAA7E33" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0I8</accession>
    <name>A0A1E7N0I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551986.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1952"/>
    <dbReference type="EnsemblBacteria" id="ARF79598">
        <property type="protein sequence ID" value="ARF79598"/>
        <property type="gene ID" value="B6264_12340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34210">
        <property type="protein sequence ID" value="OEV34210"/>
        <property type="gene ID" value="HS99_0037190"/>
    </dbReference>
    <dbReference type="OMA" id="CPCLDWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27028" checksum="80356892CDDCD50F" modified="2017-01-18" version="1">MTVDPRGSALAAFAALLADPTRAAFCCALLDGRAWTAGELARSAGVAPSTASEHLSRLITGGLLAEARQGRHRYVRLASTAVATVIEDLAVFAQATAEAAVSTGAAAAPTADAPAGDAPAPAVRSAPRNLGEATRQSAEARARTCYDHLAGRLGVTLADALLDHGLVTDHAGLAVTERGHHWLAAQAIELPPHAGRPGGRPVVRSCLDWTERRSHLGGALGAALCRTALDRAWVERIGTGRALKITPDGCRALRELLGVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M6</accession>
    <name>A0A1E7N0M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6048"/>
    <dbReference type="EnsemblBacteria" id="ARF78141">
        <property type="protein sequence ID" value="ARF78141"/>
        <property type="gene ID" value="B6264_03730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34225">
        <property type="protein sequence ID" value="OEV34225"/>
        <property type="gene ID" value="HS99_0036830"/>
    </dbReference>
    <dbReference type="OMA" id="AMPEFGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="14603" checksum="1CBBBA9C965119FC" modified="2017-01-18" version="1">MDSWIWWLLAAAALGIPLVLTAMPEFAMFAVGALAAAGVAGLGAGVVLQAVTFLVVSVALVAFVRPIAYRQLQRGPQIRMGIEALQGATAVVAETVDGEGGRIKLNGEIWSARALHPDQVYQPGQQVDVVEIQGATALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N3</accession>
    <name>A0A1E7N0N3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285693.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6060"/>
    <dbReference type="EnsemblBacteria" id="ARF78151">
        <property type="protein sequence ID" value="ARF78151"/>
        <property type="gene ID" value="B6264_03785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34235">
        <property type="protein sequence ID" value="OEV34235"/>
        <property type="gene ID" value="HS99_0036885"/>
    </dbReference>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="24812" checksum="F8F5FBF680E2D91B" modified="2017-01-18" version="1">MSRSVLVTGGNRGIGLAIAQAFAEAGDKVAVTSRSGEVPEALAKYDVLAVRCDITDAAQVDAAFTEIEQKHGAVEVLVANAGITNDTLLLRMSEEDFTSVVDTNLTGTFRVVKRASKLMMRAKKGRMVLISSVVGLSGSPGQANYAASKAGLVGFARSLARELGPRNITVNVVAPGFVDTDMTAVLSDERRAEIVSGVPLGRYAAPAEVASTVRFLSSDEAAYITGAVIPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U0</accession>
    <name>A0A1E7N0U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S08 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366559.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7632"/>
    <dbReference type="EnsemblBacteria" id="ARF78495">
        <property type="protein sequence ID" value="ARF78495"/>
        <property type="gene ID" value="B6264_05815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34296">
        <property type="protein sequence ID" value="OEV34296"/>
        <property type="gene ID" value="HS99_0036565"/>
    </dbReference>
    <dbReference type="OMA" id="ENIVCGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="51196" checksum="4DED7690C068A715" modified="2017-01-18" version="1">MAQAHRSGGPVRTARRRRVCGHARALLAILVTALVAGGAVPYVSGPGRAYVSYLVLAEREDAAGATRAGKESRAAGGQVVQEYPQIGAVLTYATGGFAERVRRRPGIAAVGATRTAPVVGPPRELAGAGDFAAGVGRGWRGDAGDGGTGTTAGTVPDPREGGAWNLAMVHAGAGTASGAVAGVGPTGDGVGGVPGPEAMRKVLVAVLDSGVDDTHPDLRAAVDPKASASCADGRPDARTGSWRPDPGVEESGHGTHVAGIIGAARDGQGVTGVAPGVRIAAVRLLGPLGQYYAENIVCGMLWAADHGAKAINDSYFADPWKYNCPEEPDQAALIAAVGRAVAYARRKGAVVVASAGNDGQDLGAARTDRRSPNDRVTGPAPTRYLGTECIRLPGELPGVVTVTAVNRDGSPSSYTNYGRGRISLAAPGGDPDGGAEGAIVSDWPGGRFAALAGTSMSAAHVTGAVAVAAALHPDFGAAQLADLLARTAAGCPVRGCGDRGHFGVGLLVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N103</accession>
    <name>A0A1E7N103_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387057.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3921"/>
    <dbReference type="EnsemblBacteria" id="OEV34369">
        <property type="protein sequence ID" value="OEV34369"/>
        <property type="gene ID" value="HS99_0036215"/>
    </dbReference>
    <dbReference type="OMA" id="RRAVYMS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20389" checksum="721DF806DB3E6510" modified="2017-01-18" version="1">MSDTRIRLLHEDDWPDVIAAEERAYAPSGLSEGGAALRSRHRASPSTCFVLEDADGFCGYLLALPYPLFRCPDLSRAEADGAGRGSSGIGGSSGIGGSNLHAHDLVIAERARGRGLADLLLLHLEETGRQAGYRTLSLVAVRGSQVLWSRLGYRARLEIGLPASYGTEAVYMAKPLAGPSADTVPSPSRAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N109</accession>
    <name>A0A1E7N109_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283316.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3931"/>
    <dbReference type="EnsemblBacteria" id="OEV34377">
        <property type="protein sequence ID" value="OEV34377"/>
        <property type="gene ID" value="HS99_0036265"/>
    </dbReference>
    <dbReference type="OMA" id="TQTMKPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046039">
        <property type="entry name" value="DUF5997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19460">
        <property type="entry name" value="DUF5997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198738" evidence="2">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="15178" checksum="BA411C922317FA63" modified="2017-01-18" version="1">MTSLKQKTSQTMKPATAAKKLGIYLAAAPTDFQEGVVSREELNALQAEPPQWLQELRKNGPHPRPVVAAKLGISISGLARGGVTEALTTAEIDAIKAENPLWLQHERANQVDVRKEEARIKAKHEKEAAEKAAKESRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N153</accession>
    <name>A0A1E7N153_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1975"/>
    <dbReference type="EnsemblBacteria" id="ARF79579">
        <property type="protein sequence ID" value="ARF79579"/>
        <property type="gene ID" value="B6264_12230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34193">
        <property type="protein sequence ID" value="OEV34193"/>
        <property type="gene ID" value="HS99_0037080"/>
    </dbReference>
    <dbReference type="OMA" id="VSSWVNQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="55018" checksum="B2660F6E8E0FBCC2" modified="2017-01-18" version="1">MRVTLLTEGTYPHQHGGVSVWCDQLVQGMPDVDFDIVAVTGTGQEPLAWELPANVRSVTTAPLWGPASEARPPRGKEMRRFLNAYERFLHSILDPVYTTHFGTELYGFADLARRGLLSPALRSERALRTLQHVWTRDYLPTAVSRPTLHDALNATDLLEHALRPLSVNPPTDGVAHAASGGLATLPGLIAAQQYGVPFLLTEHGIYLRERYLGYRTGPYRWPVKALLLGFYRMLAEESYRQAALVTPGNRYNRRWEERGGTPSAHIRTVYNGVDPAAFPPAGPEPETPTLSWAGRVDPIKDLETLIRAFAIVHREIPEARLRLFGGTPKGGEAYRDGCIALAAELGVADSVAFEGRVADITDAYAAGNVVMLSSISEGFPFTLIEAMSCGRATVSTDVGGVREAVGDTGLVVPPREPEPMAAAAIELLRDPARRARLGEGARLRVIEQFTLRQNIDGFRGIYTELLGTARWMPGGVVAVTDEVPSPDWEPRLTAVPPQHSEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q3</accession>
    <name>A0A1E7N1Q3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82040">
        <property type="protein sequence ID" value="ARF82040"/>
        <property type="gene ID" value="B6264_26965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34596">
        <property type="protein sequence ID" value="OEV34596"/>
        <property type="gene ID" value="HS99_0008830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8157" checksum="13C26DD84D668D42" modified="2017-01-18" version="1">MPLPGHGDVLTLGGEPQAVAWLPDHLVFAGGATRTRTRASRAVAEATARDEGWEDAVTVELSGGRYLLTDASYEGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D2</accession>
    <name>A0A1E7N2D2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557739.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7606"/>
    <dbReference type="EnsemblBacteria" id="ARF81786">
        <property type="protein sequence ID" value="ARF81786"/>
        <property type="gene ID" value="B6264_25395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34852">
        <property type="protein sequence ID" value="OEV34852"/>
        <property type="gene ID" value="HS99_0010325"/>
    </dbReference>
    <dbReference type="OMA" id="RVDTWNL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="789" mass="85780" checksum="468AEADD91FE1ABD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L8</accession>
    <name>A0A1E7N2L8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">HS99_0035095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5896"/>
    <dbReference type="EnsemblBacteria" id="OEV34937">
        <property type="protein sequence ID" value="OEV34937"/>
        <property type="gene ID" value="HS99_0035095"/>
    </dbReference>
    <dbReference type="OMA" id="PHGELYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="26795" checksum="CAE22A4D54D8C3BC" modified="2017-01-18" version="1">MADAVIDLNADLGEGFGRWSLTDDEALLSVVTSANVACGYHAGDPSTMRRVCALAAERGVRIGAQVSYHDLAGFGRRAMDVPPEELADEIAYQIGALQVFARAAGSRVSYVKPHGALYNRVVGDSEQAEAVVAGVLRAGAVCDGPLPVLGLPGSRLLTVAEGVGLPVVTEAFADRAYTWAGTLVPRREPDAVVHDPESVITRAVGIARDSTVEAVGGEPIAVEARSLCVHGDTPGAAQLAWRIRGALASAGVRVEAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2X6</accession>
    <name>A0A1E7N2X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4728"/>
    <dbReference type="EnsemblBacteria" id="OEV35048">
        <property type="protein sequence ID" value="OEV35048"/>
        <property type="gene ID" value="HS99_0034515"/>
    </dbReference>
    <dbReference type="OMA" id="GGWTSRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="88"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="37853" checksum="CE973097FDFA8B3F" modified="2017-01-18" version="1">MNGVRGGGVGWSSMIEDDDRGWAGTRRWVQGVLAPGERIVGVRELKGGWTSRMRRLDVAPADNGGSVGRGGGGDGDGVGVGVGGQGYPLVLRSFVKPFYRRHAPGLLAREADVLRLLETRSIPAARLRAVDATGEHCEDPSLVMTHLPGSVRVHEDGDVARRTVLLAGQLAAVHAVAVPEQERPRAWQAWTSPERVQIPAATARPRLWERAVEAIDREAPAHRGCFLHRDFHPGNVLFTGSGEQLAVSGVVDWVETSWGPADLDVAHCSTALALLHGVPAGMAFADAYERAGGVLTTGGDHLYWRLLDALAFAPDAQKVAVPWRELGRTDLSAPVLAGRLEDYLQAVFERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y2</accession>
    <name>A0A1E7N2Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737923.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4703"/>
    <dbReference type="EnsemblBacteria" id="OEV35025">
        <property type="protein sequence ID" value="OEV35025"/>
        <property type="gene ID" value="HS99_0034390"/>
    </dbReference>
    <dbReference type="OMA" id="IMESHFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="18473" checksum="D86869794AEF7D9E" modified="2017-01-18" version="1">MASPRTGRTAALSLQLSQAHNELRRRLTGVRSALGRHQGAGGDSLTAHCLAFCTALTTHHQGEDDGLFADLLRERPDLAPTVAKLVEDHGLIAALLTRVRDLAEQAVGEDGAALEAIGRELDGLAAIMESHFGYEERAIGAALDTALDVSGRDEDGWIQPVLRLRTPQGPQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N344</accession>
    <name>A0A1E7N344_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367131.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene429"/>
    <dbReference type="EnsemblBacteria" id="ARF82695">
        <property type="protein sequence ID" value="ARF82695"/>
        <property type="gene ID" value="B6264_08065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35121">
        <property type="protein sequence ID" value="OEV35121"/>
        <property type="gene ID" value="HS99_0033970"/>
    </dbReference>
    <dbReference type="OMA" id="HGRQGYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21000" checksum="A66A9503A41B7ACB" modified="2017-01-18" version="1">MDGTLVNSDAVVERCWSRWAERHGLDPVAALAVVHGRQGHATMAELLPNRPVEVNLAENQQMLAEERADTEGVVEVPGADAFLASLTGLPHALVTSADLPLARIRMDAAGLPMPPVLVTAESVGASKPDPEGFLKGAAALGFAPADCLAFEDSGAGIAAARAAGMRVIGIGPRAAAHHPDALAPTLEAVTVTTAPDGTLTLTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N384</accession>
    <name>A0A1E7N384_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554098.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000815.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5867"/>
    <dbReference type="EnsemblBacteria" id="ARF77547">
        <property type="protein sequence ID" value="ARF77547"/>
        <property type="gene ID" value="B6264_00145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34913">
        <property type="protein sequence ID" value="OEV34913"/>
        <property type="gene ID" value="HS99_0034950"/>
    </dbReference>
    <dbReference type="OMA" id="DLCPLDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="29569" checksum="B6001B53DABA381E" modified="2017-01-18" version="1">MRRRLGGAFGAAVLAAAAELPPDGDTVASPPGANDWSCRPSAAHPDPVVLVHGTFANRYENWLALSPLLKGLGYCVFALDYGTVPGITSTGSGLLLPIGGLGAVPASAAQLAHFIDLVRTATGAAKVDIVGHSQGGMLPNYYLKFLGGASKVDKLIGLAPSNHGTTLDGITKLAPYFPGVADLIYTVCQACRDQAVGSDFNTTMASRPDTVPGVHYTVISTVYDEVVTPWRTQFLNGPDVDNEVLQDHCPVTLAEHVAIAFSPTALHLVTNALDPAHATPVFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B4</accession>
    <name>A0A1E7N3B4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285442.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000463.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4466"/>
    <dbReference type="EnsemblBacteria" id="ARF78435">
        <property type="protein sequence ID" value="ARF78435"/>
        <property type="gene ID" value="B6264_05430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35162">
        <property type="protein sequence ID" value="OEV35162"/>
        <property type="gene ID" value="HS99_0033825"/>
    </dbReference>
    <dbReference type="OMA" id="RRVNVGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9242" checksum="2836D25340297F94" modified="2017-01-18" version="1">MAERRVTIGWAEGLHARPASIFVRAVTATGVPITIAKPGGNPVNAASMLGLLGLGAQGGEEVILASDAPGADEALDRLAKLVSEGLDELPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H6</accession>
    <name>A0A1E7N3H6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="9" type="ORF">HS99_0032860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000132.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5265"/>
    <dbReference type="EnsemblBacteria" id="ARF80683">
        <property type="protein sequence ID" value="ARF80683"/>
        <property type="gene ID" value="B6264_18800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35259">
        <property type="protein sequence ID" value="OEV35259"/>
        <property type="gene ID" value="HS99_0032860"/>
    </dbReference>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="501" mass="50609" checksum="4F7E1B4BD45FAA1D" modified="2017-01-18" version="1">MTALSVSTSSAASLRADALVVGVAKGPKGIVLAPGAEAVNEAFDGKLAEVLGTLGATGAEGETVKVASPAGLKAALVLAVGLGEAAEAGYELEALRRTAGVAARALAGVKKAALALPAESAEEVEAVALGGLLGSYVFGTYKGNGNGKEPVGELVVLTVRKGSKDAKAAVERAAAIGEEMNRARDLVNTAPNDLTPKSFAAIAQAAGKEHGLKVEVLDEKALTKGGFGGLLGVGNGSANPPRLVKVAYTHPKAKASLAFVGKGITYDSGGISLKPAGHNETMKCDMAGAAAVFAAVVAAKRLGLAVNVTAWLALAENMPSGSATRPGDVLRMYGGKTVEVLNTDAEGRLVLADAIVKAGEDNPDVIVDVATLTGAMVLALGTRTFGVMANSDELRENLHALAGEVGEQSWPMPLPAELKKGMTDSTIADLANMGERMGGGLVAGLFLQEFVAEGIDWAHLDIAGPAFHESAPFGYTPKGGTASAVRTLVRFAEQTAANGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P2</accession>
    <name>A0A1E7N3P2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="7" type="ORF">HS99_0033150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282842.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000774.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5323"/>
    <dbReference type="EnsemblBacteria" id="ARF80731">
        <property type="protein sequence ID" value="ARF80731"/>
        <property type="gene ID" value="B6264_19090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35306">
        <property type="protein sequence ID" value="OEV35306"/>
        <property type="gene ID" value="HS99_0033150"/>
    </dbReference>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28035" checksum="3997CED4E5264294" modified="2017-01-18" version="1">MADDLLTIAGTAFSSRLIMGTGGAPSLEVLERALLASGTELTTVAMRRVDATTQGSVLDVLTRNGIRILPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIADERTLLPDPIELLDAAETLVDDGFTVLPYTNDDPVLARKLEDVGCAAIMPLGSPIGSGLGIRNPHNFQLIVEDAGVPVILDAGAGTASDVALAMELGCSAVMLASAVTRAQDPVLMAEAMRHAAEAGRLAHRAGRIPRRFHAEASSAMAGRADLDSRERPAFRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4A9</accession>
    <name>A0A1E7N4A9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552735.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5488"/>
    <dbReference type="EnsemblBacteria" id="ARF79415">
        <property type="protein sequence ID" value="ARF79415"/>
        <property type="gene ID" value="B6264_11220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35526">
        <property type="protein sequence ID" value="OEV35526"/>
        <property type="gene ID" value="HS99_0032030"/>
    </dbReference>
    <dbReference type="OMA" id="DWHTGYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="379" mass="40715" checksum="5426C56B351D020B" modified="2017-01-18" version="1">MTVLDHRHHTGVPGWMPGATAPRTDPAPLLPDVSPVRVLGTPALEKHDPALLRELYRRLVVGRRYNQQATTLTKQGRLAVYPASTGQEACQIAAALVLGERDWLFPSYRDTLAVVSRGVDPLEALTLLRGNAHTGYDPRASRTAPLCTPLGTQAPHAVGLAHAARLRGEPVVALAMLGDGGTSEGDFHEALNFAAVLRAPVVFLVQNNGYAISVPLSAQSAAPSLAHKAVGYGMPGRLVDGNDAPALHSVLTEAVERARAGGGPTLVEALTYRIEAHTNADDATRYRTEPEVDAWREHDPILLMDRALRELHLLDDGLAQDAADEAEALAARMRAEFHADPELDPMALFTHVYAEPTPQLREQAAQLSAELAAEAEVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H3</accession>
    <name>A0A1E7N4H3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="13" type="ORF">HS99_0006600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280411.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5378"/>
    <dbReference type="EnsemblBacteria" id="ARF80778">
        <property type="protein sequence ID" value="ARF80778"/>
        <property type="gene ID" value="B6264_19365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35585">
        <property type="protein sequence ID" value="OEV35585"/>
        <property type="gene ID" value="HS99_0006600"/>
    </dbReference>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="35726" checksum="CA490905CED1D5B4" modified="2017-01-18" version="1">MKIGIVGATGQVGGVVREILAERNFPVAQLRLFASARSAGRTLPWQGTEITVEDAATADYTGLDIVIFSAGGSTSKALAPKVAAAGAVVIDNSSAWRRDPEVPLVVSEVNPEAVADRPKGIIANPNCTTMAAMPVLRPLHEEAGLAALVVSTYQAVSGSGVAGVAELQDQAAKVVDGASALAHDGSAVEFPEPRVYRRPIAFNVVPLAGAIVEDGSNETDEEQKLRHESRKILGIPALKVAGTCVRVPVFSGHSLQINARFERPISPERAVELLTGAPGVELSDIPTPLQAAGRDPSYVGRIRADETVENGLSLFVSNDNLRKGAALNAVQLAELVAKELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H5</accession>
    <name>A0A1E7N4H5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">HS99_0006670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280443.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5393"/>
    <dbReference type="EnsemblBacteria" id="ARF80790">
        <property type="protein sequence ID" value="ARF80790"/>
        <property type="gene ID" value="B6264_19435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35597">
        <property type="protein sequence ID" value="OEV35597"/>
        <property type="gene ID" value="HS99_0006670"/>
    </dbReference>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="26942" checksum="5EA346D8D3E99AA1" modified="2017-01-18" version="1">MTLAVRVIPCLDVDAGRVVKGVNFQNLRDAGDPVEMAKLYDAEGADELTFLDITASSGDRETTYDVVRRTAEQVFIPLTVGGGIRAVEDVNKLLRAGADKVGVNTAAIARPELIREIAQRFGRQVLVLSVDARRCPEGTETASGYEVTTHGGRQGTGLDAVEWAGRAAELGAGEILLNSMDADGTKDGYDLEMIRAVRKAVSVPVIASGGAGKLGDFAPAVEAGADAVLAASVFHFGDLRIGEVKDALREAGHPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K0</accession>
    <name>A0A1E7N4K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0032825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550589.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000493.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2373"/>
    <dbReference type="EnsemblBacteria" id="OEV35393">
        <property type="protein sequence ID" value="OEV35393"/>
        <property type="gene ID" value="HS99_0032825"/>
    </dbReference>
    <dbReference type="OMA" id="LIMWRLS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="303"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="497"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="762"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="862" mass="89058" checksum="E36E133940FBD1FB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q8</accession>
    <name>A0A1E7N4Q8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malto-oligosyltrehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051746737.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene907"/>
    <dbReference type="EnsemblBacteria" id="ARF80864">
        <property type="protein sequence ID" value="ARF80864"/>
        <property type="gene ID" value="B6264_19865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35670">
        <property type="protein sequence ID" value="OEV35670"/>
        <property type="gene ID" value="HS99_0007095"/>
    </dbReference>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="827" mass="89391" checksum="693AB08C995A0050" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R2</accession>
    <name>A0A1E7N4R2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385538.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3882"/>
    <dbReference type="EnsemblBacteria" id="OEV35453">
        <property type="protein sequence ID" value="OEV35453"/>
        <property type="gene ID" value="HS99_0032355"/>
    </dbReference>
    <dbReference type="OMA" id="NQCELEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="48010" checksum="BF97EE030470DFC4" modified="2017-01-18" version="1">MELSRPPVTRENDVSSTTPGTADAAGRPQAAWLVLGGLHLLNGTAPLADADPVVLVPLDRPFEQTFPGNTVVVDWAALGTVRLEARDVAGTRTHGAVAQGAGLFPDMLPGAELRAAVAAVSDAANGPLVPLFYVSSDGTSAHVHSQIRFLAEDACFIRITEEPVPAAGIEELGWLPQALARHAEQFLFLNNHQRYYRKCFPGKELEYKYTLTPPVDAWTFTLELYRDVKGGALPGYLMEYRDEYQAWDYLNHLFEVTGPTEDERGYASFIPTTDGKHLLKRKWYAEDAFERRETHTYGLSLADDGGFERYVTEELKVEAVRLPSFRRVRYDINFESARTGHVYGIFFDHCSLVDARDVTLNQCELEYLRSRTAVEPDEADVSKEMAEIATWLESFLRERGLNSERGFYSKRTFLKDAVAARPELARPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U3</accession>
    <name>A0A1E7N4U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0007370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene853"/>
    <dbReference type="EnsemblBacteria" id="ARF80911">
        <property type="protein sequence ID" value="ARF80911"/>
        <property type="gene ID" value="B6264_20140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35709">
        <property type="protein sequence ID" value="OEV35709"/>
        <property type="gene ID" value="HS99_0007370"/>
    </dbReference>
    <dbReference type="OMA" id="GIFHQYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="813" mass="82463" checksum="A3C68274EC0BCDDE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W4</accession>
    <name>A0A1E7N4W4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386001.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene811"/>
    <dbReference type="EnsemblBacteria" id="ARF80945">
        <property type="protein sequence ID" value="ARF80945"/>
        <property type="gene ID" value="B6264_20355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35741">
        <property type="protein sequence ID" value="OEV35741"/>
        <property type="gene ID" value="HS99_0007585"/>
    </dbReference>
    <dbReference type="OMA" id="HWFLPGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21813" checksum="AFF9F119E4B8B28B" modified="2017-01-18" version="1">MTDTTDRTDTSARAAELAVLFPALHAPQYWAWGRYDAQFSTELPPDELVTNIHLVGFADGDVVLCRDDRDHWFLPGGTREQDESVTDCLERELREEAGARLLGEPGWLGAHRCHTEDAVPYRPWQPHPDKAWLWGWGEVVLDSTPTNPADGEQVVEVRAVPVDEAQRLLLTGHDAWWGELIELAAELRRRAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C3</accession>
    <name>A0A1E7N5C3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">HS99_0008545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286227.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7277"/>
    <dbReference type="EnsemblBacteria" id="ARF81108">
        <property type="protein sequence ID" value="ARF81108"/>
        <property type="gene ID" value="B6264_21320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35897">
        <property type="protein sequence ID" value="OEV35897"/>
        <property type="gene ID" value="HS99_0008545"/>
    </dbReference>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="7061" checksum="813914D6326086DD" modified="2017-01-18" version="1">MPKQKTHSGASKRFKISGSGKVLRERAGRRHLLEHKPSTLTRKLAGTVEMAPADAKKIKKLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5K8</accession>
    <name>A0A1E7N5K8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0008120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3376"/>
    <dbReference type="EnsemblBacteria" id="OEV35987">
        <property type="protein sequence ID" value="OEV35987"/>
        <property type="gene ID" value="HS99_0008120"/>
    </dbReference>
    <dbReference type="OMA" id="AVYFHFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="25041" checksum="8126F8D741118465" modified="2017-01-18" version="1">MWPTPKIQRSGATGPLLRQERAERTREQILHCAARIFAERGYQQTGIKDVADEVAMTKGAVYFHFPNKQALAIAVVDELYSRWPVTLEAVRGKGLSPLDTVIEMFNAATVAFLEDPIMQAGTRLQNERDAVDVELPPPYVDWTNLISMLMREAHQQGQLAQHVDPDVAARVAVAAFFGAQHISDNLNGRADFAERWREVRDTLFPALRARPSLAADPDRPVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P9</accession>
    <name>A0A1E7N5P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0031415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000230.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene503"/>
    <dbReference type="EnsemblBacteria" id="ARF78817">
        <property type="protein sequence ID" value="ARF78817"/>
        <property type="gene ID" value="B6264_07715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36020">
        <property type="protein sequence ID" value="OEV36020"/>
        <property type="gene ID" value="HS99_0031415"/>
    </dbReference>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42364" checksum="FC5133828F5DB3B6" modified="2017-01-18" version="1">MSLPPLVEPADELTVDEVRRYSRHLIIPDVGMAGQKRLKNAKVLCVGAGGLGSPALLYLAAAGVGTLGIVEFDVVDESNLQRQVIHGQSDVGRSKAESARDSVKEINPYVDVVLHEERLDNSNVMEIFSGYDLIVDGTDNFATRYLVNDAAVLLGKPYVWGSIYRFDGQASVFWAEHGPCYRCLYPEAPPPGMVPSCAEGGVLGVLCASIGSIQVNEAIKLLAGIGDPLVGRLMIYDALEMNYRQVKVRKDPNCAVCGENPTVTELIDYEAFCGVVSEEAQAAAAGSTVTSQQLKQWQDDEEDIYLIDVREPGEYEIVNIPGAVLIPKNEFLMGDALEKLPQDKKIVLHCKSGVRSAEVLAVVKAAGFANAVHLGGGVLGWVNQIEPHKPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Q2</accession>
    <name>A0A1E7N5Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000723.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene490"/>
    <dbReference type="EnsemblBacteria" id="ARF78828">
        <property type="protein sequence ID" value="ARF78828"/>
        <property type="gene ID" value="B6264_07775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36009">
        <property type="protein sequence ID" value="OEV36009"/>
        <property type="gene ID" value="HS99_0031360"/>
    </dbReference>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="30154" checksum="FB4045DE52398DF2" modified="2017-01-18" version="1">MRIDLHAHSNASDGTDSPAELVGAAVVAGLDVVALTDHDTVAGHAEAADAVHALPDGTRLTVVPGAELSCVVDGISMHLLAYLFDPEEPEFARERELVRTDRFRRGRAVVERCRELGADISWEQVQRIAGAGSVGRPHIASALVEAGVVGTVSDAFTPDWLANGGRADVRKHETDPVAAVRLVRAAGGVPVFAHPGAVKRGRTVPDQVIADLAAAGLAALEVDHTDHDEETRRRLRGLAGDLGLLVTGSSDYHGGRKTVRLGEHTTDPEVYEALLAQATGAKPITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R8</accession>
    <name>A0A1E7N5R8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287501.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000564.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene516"/>
    <dbReference type="EnsemblBacteria" id="ARF78804">
        <property type="protein sequence ID" value="ARF78804"/>
        <property type="gene ID" value="B6264_07645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36031">
        <property type="protein sequence ID" value="OEV36031"/>
        <property type="gene ID" value="HS99_0031480"/>
    </dbReference>
    <dbReference type="OMA" id="EGIAYTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="9080" checksum="C216CD390D867363" modified="2017-01-18" version="1">MSGTVTMYSTTWCGYCNRLKSQLDREGIGYTEINIEEDPASAAFVESVNNGNQTVPTVLVQPVGGGEQVVMTNPSLIQVKKALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z2</accession>
    <name>A0A1E7N5Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)H-quinone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281007.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4990"/>
    <dbReference type="EnsemblBacteria" id="ARF80057">
        <property type="protein sequence ID" value="ARF80057"/>
        <property type="gene ID" value="B6264_15050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36112">
        <property type="protein sequence ID" value="OEV36112"/>
        <property type="gene ID" value="HS99_0031070"/>
    </dbReference>
    <dbReference type="OMA" id="CLMAVGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="52590" checksum="8833C67088AF3F46" modified="2017-01-18" version="1">MGYVTRIVIIGGGPGGYEAALVAAQLGAEVTVVDRDGLGGSAVLTDCVPSKTLIATAEVMTTFDSSYEELGITVDQDGAGDRESKVIGVDLGKVNRRVKRLAIAQSHDITQSVTRAGVTVLRGRGRLGAGGQAVDGSREVLVDAPDGAVHSLRADAVLIATGAHPRELPDAQPDGERILTWTQVYDLEELPRELIVVGSGVTGAEFAGAYQALGSKVTLVSSRDRVLPGEDPDAAEVLEDVFRRRGMNVMGRSRAETVKRISARAEGTQGPSSPEAGEEGWIGDRVEVTLSDGTVIEGTHCLMAVGSIPNTADMGLEEAGVKLNDWGQIQVDRVSRTSAPGVYAAGDCTGVFMLASVAAMQGRIAMYHALGDAVQPLNLKTVASNVFTDPEIATVGYTAADVECGKMDAVVVKLPLRGNPRAKMQGIRDGFVKLFCRPGTGIVVGGVVVAPRASELIHPIALAVDANLTVEQVASAFTVYPSVSGSTAEAARQLHIRKRSAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N621</accession>
    <name>A0A1E7N621_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553191.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36135">
        <property type="protein sequence ID" value="OEV36135"/>
        <property type="gene ID" value="HS99_0031200"/>
    </dbReference>
    <dbReference type="OMA" id="EHHATFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="31779" checksum="13782BE33417EE65" modified="2017-01-18" version="1">MANRQNPTLRQRRLGAELRRMREQAGFAGSHLARLLGVTPALVTQMENGKSAVSVERLHEIAEACMCANAPLVDALAGMARERDRAWWDEYRNTLTAAPIDVAEMEGHAKRLKSFNIGFIPGLLQTVPYAAAVFARGFTPLPGREVDRRVGFRLRRQQTIRSGETPYVALVHEAALRIQYGGPAVLKEQLGSLVEDSQLPGVSLRVVPFDTADFPGPSENLIYAEGPVPELDTVQADSSHGSHIFDSPAQLAGYRAIFERIEAVALPESESRDYIRSIMKELNDRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N622</accession>
    <name>A0A1E7N622_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291246.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80086">
        <property type="protein sequence ID" value="ARF80086"/>
        <property type="gene ID" value="B6264_15210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36141">
        <property type="protein sequence ID" value="OEV36141"/>
        <property type="gene ID" value="HS99_0031230"/>
    </dbReference>
    <dbReference type="OMA" id="WCLGCAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="6926" checksum="1A7D86BDA4DD6E70" modified="2017-01-18" version="1">MADCTQCSAPAVIEDLDVQPPQPWCLGCATTLVRAGDPVLNYRSLSGGSEYQRILAGGSTQVLPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H3</accession>
    <name>A0A1E7N6H3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6343"/>
    <dbReference type="EnsemblBacteria" id="ARF78780">
        <property type="protein sequence ID" value="ARF78780"/>
        <property type="gene ID" value="B6264_07480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36053">
        <property type="protein sequence ID" value="OEV36053"/>
        <property type="gene ID" value="HS99_0031645"/>
    </dbReference>
    <dbReference type="OMA" id="APDWWNV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="35961" checksum="EAA3997FE82CF946" modified="2017-01-18" version="1">MRIFHRARHRPSATWRQTTDRAFTLIGDGRYEDAGALLVMAADLEPWLSDSWFNLALLHKFRRDWEQARSAGLRAVALLDREHGAPDWWNLGITATALQDWPLARRAWQAYGLKLPGGPGGDGPVSLDLGTTPVRLSPDGESEVVWGRRLDPARIEVLSIPLPSSGRRWGEVVLHDGAPHGERVTDGVAYPVFDEIELWAPSPVPTYVVLLQAATAGDRDALERLVAEAGYAAEDWTSSVRLLCRACSESRMASDDGVVAHHDPHDDGDAAHPGHLSHLSQGGAAGMSWLVERECGIAAPAYLVRVLLDRWVAAAPATRAYRDLEEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V5</accession>
    <name>A0A1E7N6V5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7727"/>
    <dbReference type="EnsemblBacteria" id="ARF82334">
        <property type="protein sequence ID" value="ARF82334"/>
        <property type="gene ID" value="B6264_28755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36374">
        <property type="protein sequence ID" value="OEV36374"/>
        <property type="gene ID" value="HS99_0029910"/>
    </dbReference>
    <dbReference type="OMA" id="QVTTCTN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="11359" checksum="FD609797D0226E67" modified="2017-01-18" version="1">MAATATSEAGTVACATVLNRPCITHQVDGDGIVGIAQVNADPTQLTMVQVEVRSQQAWGSPWETVASASAVRVGSVQATTPKVTGPAPHIICATAGPALDASKQVTTCTNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N729</accession>
    <name>A0A1E7N729_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387136.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1468"/>
    <dbReference type="EnsemblBacteria" id="ARF79186">
        <property type="protein sequence ID" value="ARF79186"/>
        <property type="gene ID" value="B6264_09865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36512">
        <property type="protein sequence ID" value="OEV36512"/>
        <property type="gene ID" value="HS99_0028715"/>
    </dbReference>
    <dbReference type="OMA" id="KVTVRYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="9900" checksum="B60BFF719D22934C" modified="2017-01-18" version="1">MGATTEPASGARARGTIRYWAAAKSEAGLAEEPYEAATLAEALAAAKERHADRPKLVQLLGHCSYLVDGAQVGGRDHAAVALTEGGTVEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N793</accession>
    <name>A0A1E7N793_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552623.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7901"/>
    <dbReference type="EnsemblBacteria" id="ARF79131">
        <property type="protein sequence ID" value="ARF79131"/>
        <property type="gene ID" value="B6264_09550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36566">
        <property type="protein sequence ID" value="OEV36566"/>
        <property type="gene ID" value="HS99_0029035"/>
    </dbReference>
    <dbReference type="OMA" id="DWHAELW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="31285" checksum="07BE59C948FE8CF1" modified="2017-01-18" version="1">MSTDFQQARIALGQRLRELRAEGGLTGRQLADRLDWAQSKVSKLETGRQTATHDDLKAWATGVGQPEAAAELSARLRSFESGTRSWRRQLAAGHRPVQDTLTAEHDRSTIMRAWESAMVVGILQTADYARHVFNAYVDLHQSPRDVEDAVRARIQRQESLYRPGRKYHVIMGEAALRALICPPAVMAAQLDRLSGVIGLDTVSLGIVPFEAPLKLPPANGFWIHDERLVVVEDWHAELWLDQPENVALYLRVWETLAGAAVYGADAHRVITRCRRALGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N867</accession>
    <name>A0A1E7N867_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4844"/>
    <dbReference type="EnsemblBacteria" id="ARF83144">
        <property type="protein sequence ID" value="ARF83144"/>
        <property type="gene ID" value="B6264_29245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36844">
        <property type="protein sequence ID" value="OEV36844"/>
        <property type="gene ID" value="HS99_0027765"/>
    </dbReference>
    <dbReference type="OMA" id="CYFAWAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="656" mass="71138" checksum="8C26E7A1A9D5249B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N869</accession>
    <name>A0A1E7N869_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281987.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000123.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6473"/>
    <dbReference type="EnsemblBacteria" id="ARF78665">
        <property type="protein sequence ID" value="ARF78665"/>
        <property type="gene ID" value="B6264_06830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36887">
        <property type="protein sequence ID" value="OEV36887"/>
        <property type="gene ID" value="HS99_0026855"/>
    </dbReference>
    <dbReference type="OMA" id="FHYDLDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021125">
        <property type="entry name" value="DUF2127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09900">
        <property type="entry name" value="DUF2127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="29530" checksum="DDE5A571B9066195" modified="2017-01-18" version="1">MFKRDWDRRTCAKRGHITYAPTEPELASRLHAATAVGDAWRCLRCGDFSLGAPHGSGPAANAPLVPRGKALRDLFILRFLAVERVLRGVIIILMAWGVWKFSNSQEAVQRVFEEDLTVFKPVTDHFHWDLDHAPIVETIRKTFGYQKKTLLIVAGAMIAYALIEIVEAVGLWLGRRWAEYLTVVATAAFLPLEGYELHEHISAVKICTLLLNIAAVLWIMLSKRLFGLRGGVVAFEAERHSASLLEVEQAAGAVPAPGHGHGAHARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C7</accession>
    <name>A0A1E7N8C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286995.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6815"/>
    <dbReference type="EnsemblBacteria" id="ARF78610">
        <property type="protein sequence ID" value="ARF78610"/>
        <property type="gene ID" value="B6264_06515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36942">
        <property type="protein sequence ID" value="OEV36942"/>
        <property type="gene ID" value="HS99_0027180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="411" mass="44641" checksum="A3C9B497E0415BE7" modified="2017-01-18" version="1">MTARNAVRDDFPVLRREFDGQSISYLDNAATTLKPRPVIRAITEYYETNGANIHRGKHRLSEEASDAYEGARVVIARHLGAAANEVVLLRNTTEALNLVAGGLDLPPDARVVGCLDAHHSQLLPWRRVGQLELTRLDEHGRLDRDHFRTLLRGRPHVVALTHCSNVTGVVHPVAELVAEIRAACDAVIVLDAAQSLPHQRIDVQELDVDFMAFSMHKMLGPTGVGVLFGRSERLARLRPASVGGGMVDWVDLDGSVDRRIPYRFEAGTPAIASIIGSAAAIRYLEAQDTPERHRHAQELGAALIGGAVARPGVRLIGPPDSTDRIALVSLRLDDSIPTGEVARLLSDSYGYMVRSGHMCAQPLVSGMAGGEVLRVAAYLYNDVSEIEGFYQALDELVSWIAPTAAMEGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T7</accession>
    <name>A0A1E7N8T7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366244.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6685"/>
    <dbReference type="EnsemblBacteria" id="ARF81627">
        <property type="protein sequence ID" value="ARF81627"/>
        <property type="gene ID" value="B6264_24405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37101">
        <property type="protein sequence ID" value="OEV37101"/>
        <property type="gene ID" value="HS99_0004585"/>
    </dbReference>
    <dbReference type="OMA" id="INRITRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="471" mass="49329" checksum="2F1E52E927DC56F0" modified="2017-01-18" version="1">MTSTRGRVAALVGAVAVAACTTLAAPAAGFAATAGPDRAGPGISTGGGITGQAPCPDAPEFVCGTLTVPLDHGGRTPGNLQLDVAMTGNADAPKGDLLFLTGGPGQPGVPTIKRMASKLEPVLKDYRLVVYDQRGTGRGALRCPGLQEDMGSSDLAVPRKRSIADCATALGPNARFYSTADTVADIDQLRRALGARRLTLDGVSYGTFVAERYALTHPAHVARLVLDSVAPQQGFDPLDLAALPATARVLRTACRATGCTTDPAEDLAATVRRYGNGAQILSALTGYEFIDPDYGGVPEILHEAAAGQPAKLQDFFDLVHREVDAASAEELSQGLHSAALCADSRFPWGTTDTPVADRTTALERTRQQLTAEQTWPYDPATATGLGSLLVCLDWPREQVPPAPSVHRKLPNVPVLLLGGDRDISTPYEVLQKVAETAHDPQIVIVPGAAHSVQNRAANPAGRQAVYDFLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U1</accession>
    <name>A0A1E7N8U1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0004665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555739.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6668"/>
    <dbReference type="EnsemblBacteria" id="ARF81615">
        <property type="protein sequence ID" value="ARF81615"/>
        <property type="gene ID" value="B6264_24325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37115">
        <property type="protein sequence ID" value="OEV37115"/>
        <property type="gene ID" value="HS99_0004665"/>
    </dbReference>
    <dbReference type="OMA" id="ILTVDHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="46759" checksum="9B5D6EE8F21901AF" modified="2017-01-18" version="1">MNGRGRAVAAVLLAATAVLGVVAAPGAVAAPGAVAEPERGTERQASAWLPQPTGPYPVGTTSLQLTDDRRDDPWKPGQHRKLMISFWYPTTRPATGDDRTPYMLPPAADHFGSAGSVGQSEHGFEPGRTDWKGIRTHARADAPAVPGGRRPVVLYSAGFGDPRTWGTGLVEDLASRGYTVVTVDHTYDASEVAFPDGDLATSVLPALMEQPGLDMGALLRKVLQTRVDDTRFVLDQLAGLHHDDGRHHDQQLPAGLAASLDLDRIGMVGHSGGGSTALQTMHDDPRLKAGVNLDGQLHFPGPDGRTGVFLPSVAEDGLTRPFLLMGTQDPDSGSYHRQPGWDALWQHSTGWHADVTLTGSRHGSYTDAQSLLPQLARQGAISGANLTADVGDVRPDRAVLATRSYVASFFDRWLRGHDDHLLDGPSPRFPEMIYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y4</accession>
    <name>A0A1E7N8Y4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="4" type="ORF">HS99_0027060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6838"/>
    <dbReference type="EnsemblBacteria" id="ARF78631">
        <property type="protein sequence ID" value="ARF78631"/>
        <property type="gene ID" value="B6264_06630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36923">
        <property type="protein sequence ID" value="OEV36923"/>
        <property type="gene ID" value="HS99_0027060"/>
    </dbReference>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13512" checksum="77FE391429318D54" modified="2017-01-18" version="1">MSNPQHLQYTKEHEWLTAAVDGVSTVGITKHAADALGDIVYVQLPEVGDTVTAGETCGELESTKSVSDLYSPVTGEVTEVNQDVLDDNALVNSAPFEAGWLFKVRVEATDELLSADEYDALTNPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z7</accession>
    <name>A0A1E7N8Z7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6202"/>
    <dbReference type="EnsemblBacteria" id="ARF81559">
        <property type="protein sequence ID" value="ARF81559"/>
        <property type="gene ID" value="B6264_23975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37176">
        <property type="protein sequence ID" value="OEV37176"/>
        <property type="gene ID" value="HS99_0005010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9716" checksum="1A015E2900791FA9" modified="2017-01-18" version="1">MNRTELVAAISERAGLPKKDADAVLSAFAEIAGEIVFKGDEKLLIPGFLTLERTHRAARKARNPQTGDPIEIPAGYSVKATAGSKLKEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N927</accession>
    <name>A0A1E7N927_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556589.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6182"/>
    <dbReference type="EnsemblBacteria" id="ARF81543">
        <property type="protein sequence ID" value="ARF81543"/>
        <property type="gene ID" value="B6264_23880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37189">
        <property type="protein sequence ID" value="OEV37189"/>
        <property type="gene ID" value="HS99_0005095"/>
    </dbReference>
    <dbReference type="OMA" id="EHIWDSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24563" checksum="8C640C9144FDFDEC" modified="2017-01-18" version="1">MRVLVIEDDAGLAPVVVRGLREAGFAVDLAGDLAEADLKLAVNAYDCMVADRSLPDGDALTLVAALRRAGSRLPVLLLTALDAVADRVAGFEHGADDYLVKPFAFAELNARVRALCRRDQPARLPELRVGDLELDFPRRRVRRAGVLLTLTAKEFAVLEVLMLRAGEVVTRSELIERCWDEHTEPLSNVVDVLIGQLRRRLGPPELIETVRGAGYRLADPADRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N941</accession>
    <name>A0A1E7N941_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557243.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene149"/>
    <dbReference type="EnsemblBacteria" id="ARF81744">
        <property type="protein sequence ID" value="ARF81744"/>
        <property type="gene ID" value="B6264_25145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36983">
        <property type="protein sequence ID" value="OEV36983"/>
        <property type="gene ID" value="HS99_0003870"/>
    </dbReference>
    <dbReference type="OMA" id="VGFFVRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="56" mass="6198" checksum="D0199ADB5CBBF150" modified="2017-01-18" version="1">MVPLLLVLLLALLLFGAGFALKALWWVAIVVLVVWLLGFVARGTGASGSRGRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B4</accession>
    <name>A0A1E7N9B4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37258">
        <property type="protein sequence ID" value="OEV37258"/>
        <property type="gene ID" value="HS99_0005515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8598" checksum="0F60648E35DE9353" modified="2017-01-18" version="1">MEDPPGLRRGFVPRGGRHGGTHLRQFLHGRVRRRRVVPAGRRAPRVVTEAMLVETGRAVEDADIQYLEFRGWIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M2</accession>
    <name>A0A1E7N9M2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5449"/>
    <dbReference type="EnsemblBacteria" id="OEV37344">
        <property type="protein sequence ID" value="OEV37344"/>
        <property type="gene ID" value="HS99_0006045"/>
    </dbReference>
    <dbReference type="OMA" id="VALYRWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198918" evidence="2">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21047" checksum="B61C1F54DBD4E5D8" modified="2017-01-18" version="1">MTAAPRARSAATATAVAGAPTLVFLAANGTGGPRAASVAATVTAVLVLGWRLRARQHVPHAVLGALLATGCAAVAAWTGQARGFFLLPMAVPAAATAACLLSLAADRPLAGLVANRVVGGPPGWRSNRVLHRFYTVSTVVIALVSFASLAAQVALYRWSDVTWLGLLHVLMGPLWAAITALSLLLARRTVTRERNAADADGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P8</accession>
    <name>A0A1E7N9P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556153.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7457"/>
    <dbReference type="EnsemblBacteria" id="ARF83049">
        <property type="protein sequence ID" value="ARF83049"/>
        <property type="gene ID" value="B6264_24750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37417">
        <property type="protein sequence ID" value="OEV37417"/>
        <property type="gene ID" value="HS99_0004255"/>
    </dbReference>
    <dbReference type="OMA" id="ANIMAME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="21583" checksum="91650BB0570BEC7B" modified="2017-01-18" version="1">MLRALAATGVATSLFGSPAFAGSPPPPQDRIVIDSVTASGTGCPTGTAAAAVSPDGTAFTVTYSNYLAQIGPGASPADAQKDCRLSLHVHAPGGFTYAVVSAGYSGFASLAPGASATQRASYHFQGDPRTTTSNHHFKGPFDNTWRTTDTVPVTAVVFAPCGEERSLDINTELQVAQGTSSPSATSFMEMDSTDGRISTVYRVALQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q9</accession>
    <name>A0A1E7N9Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386669.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6633"/>
    <dbReference type="EnsemblBacteria" id="ARF83040">
        <property type="protein sequence ID" value="ARF83040"/>
        <property type="gene ID" value="B6264_24150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37426">
        <property type="protein sequence ID" value="OEV37426"/>
        <property type="gene ID" value="HS99_0004840"/>
    </dbReference>
    <dbReference type="OMA" id="VVHCQGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="36471" checksum="219296DF876BF0B6" modified="2017-01-18" version="1">MTALDGRPLTLVHVQGRHPPTRGPVLVAHGAGVRAELFRPPLPRTFVDALIDDGWDVWLFNWRASIDLDPVPWTLDQAAAYDHPAAVAHVLAATGADRLKAVVHCQGSTSFMMALAAGLLPEVDTVVSNAVSLHPVVPGWSRFKIGRLAPLIARALPAISPGWGDKPEGPLSRLIVGFVRATHPECGNRVCRMVSFTYGTGWPALWSHENLDERTHDWIRGEFADVPMTFFAQMNRCIRAGHLVRTEPVATLPRSVVDRAPSTDARIVLLAGEQNQCFLAESQQRTFDFLQRHRPGRDSLHLLPGYGHLDVFLGRRAAADTYPLILKELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9S1</accession>
    <name>A0A1E7N9S1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385555.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37441">
        <property type="protein sequence ID" value="OEV37441"/>
        <property type="gene ID" value="HS99_0005305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198924" description="SLT domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="57"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13662" checksum="A78AA51574319B76" modified="2017-01-18" version="1">MPAFKLRMRTSAAILAGAAGVTALGAAVVPAVASAADASPQAVAARIVPADQLASFSQVVSHESGWNVTATNPSSGSYGLGQALPASKMASAGADWKTNPATQIKWTLDYMNTRYGSPNAAWAFWQNHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9S5</accession>
    <name>A0A1E7N9S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385701.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1310"/>
    <dbReference type="EnsemblBacteria" id="OEV37445">
        <property type="protein sequence ID" value="OEV37445"/>
        <property type="gene ID" value="HS99_0005520"/>
    </dbReference>
    <dbReference type="OMA" id="PRNGLMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="36206" checksum="CFC742EE15956D9C" modified="2017-01-18" version="1">MPGPPFRPVGPARRPELLQALRTGPFDLALRTAIRASGLSLEGIQRRLDRRGVQVSVSSLSYWQRGRSRPERPDSLAAVRVLEEVLGLHRDELVVLLGPRRPRGRWVEHVPGSLDYASTFGDPAVEGVLADLDPRTNARLETLHTRVDVHIGARREERRVDIVQVVRALAAGVDRLILLTQAKPEMSAGADLGLSDLVGCRLGRRRVDRERGLAAAELLLDLVLGPGQCTVVEYSYAYPSKQVATHYQRMVRFPGKNLVLRALFDPADLPAGCTALWRPQHDAPPSSDEQLRVSPVGHACAVFPDVTPGIYGLSWEWNEDLAPVPPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V8</accession>
    <name>A0A1E7N9V8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79103">
        <property type="protein sequence ID" value="ARF79103"/>
        <property type="gene ID" value="B6264_09400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37469">
        <property type="protein sequence ID" value="OEV37469"/>
        <property type="gene ID" value="HS99_0025955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="14399" checksum="9F61241753F7988F" modified="2017-01-18" version="1">MARALSDPDLHWAAQHYLSIPAELVESLHPADGLDLPLEDEIYYLPGQALVRVIEHALSVSQSVDPEARGEVLKEWRQYVALHVALDRLPLTSQHAYELSRQSDELARRLHRKGTSGAEALRAYGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG6</accession>
    <name>A0A1E7NAG6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="6" type="ORF">HS99_0025560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280765.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1682"/>
    <dbReference type="EnsemblBacteria" id="ARF79929">
        <property type="protein sequence ID" value="ARF79929"/>
        <property type="gene ID" value="B6264_14350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37672">
        <property type="protein sequence ID" value="OEV37672"/>
        <property type="gene ID" value="HS99_0025560"/>
    </dbReference>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="23680" checksum="E3C9F8A7368040A8" modified="2017-01-18" version="1">MSTIDILSPAGDKTGSLELPAEIFDAKVSVPLMHQVVVAQLAAARQGTHKTKTRGEVRGGGKKPYRQKGTGRARQGSTRAPQFAGGGVVHGPVPRDYSQRTPKKMIAAALRGALTDRARHNRIHVVTGVTATEAPSTKAAKGLFGKITDRKNVLLVVERSDELGLKSARNLPNVHILDAGQLNTYDVLVSDDVVFTQAAFERFVAGPAASAKAVAAEGELEGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ9</accession>
    <name>A0A1E7NAJ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280837.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1639"/>
    <dbReference type="EnsemblBacteria" id="ARF79969">
        <property type="protein sequence ID" value="ARF79969"/>
        <property type="gene ID" value="B6264_14565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37711">
        <property type="protein sequence ID" value="OEV37711"/>
        <property type="gene ID" value="HS99_0025775"/>
    </dbReference>
    <dbReference type="OMA" id="DEVYWGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22239" checksum="A57DD476AE22749E" modified="2017-01-18" version="1">MLLLAFDTATPAVTAAVHDGTAVLAETHQVDARRHGELLLPAIDQVLRAAGVDKHRLTGIAVGVGPGPYTGLRVGLVTAAALGHALGVPVHGVCTLDAIAFQARAEGLAGQPFTVATDARRKEVYWASYDADGSRTDGPGVDRPAELTPAARSVGAGALLYPDAFPGAHGPEHVSAGALAGFAAAELSAGRELLPNVPLYLRRPDAQVPAGYKAVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM3</accession>
    <name>A0A1E7NAM3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI</name>
        <name evidence="2" type="ORF">HS99_0026350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1162"/>
    <dbReference type="EnsemblBacteria" id="ARF79037">
        <property type="protein sequence ID" value="ARF79037"/>
        <property type="gene ID" value="B6264_09005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37533">
        <property type="protein sequence ID" value="OEV37533"/>
        <property type="gene ID" value="HS99_0026350"/>
    </dbReference>
    <dbReference type="OMA" id="VDTPHAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22322" checksum="C2FB966A16058E13" modified="2017-01-18" version="1">MSSDQTGRPERADRPSILGPAAGFGVTFRAMFKKRLTEQYPEQKKPTAPRFHGRHQLNRHPDGLEKCVGCELCAWACPADAIYVEGADNRDEERYSPGERYGAVYQINYARCILCGLCIEACPTRALTMTNEYELADSSRKDLIFTKEQLLVGLSEGMVDTPHAIFPGTDEGAYYRGEVTAAAPGTVQQERTDREKEVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAP9</accession>
    <name>A0A1E7NAP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3454"/>
    <dbReference type="EnsemblBacteria" id="ARF78098">
        <property type="protein sequence ID" value="ARF78098"/>
        <property type="gene ID" value="B6264_03455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37766">
        <property type="protein sequence ID" value="OEV37766"/>
        <property type="gene ID" value="HS99_0024545"/>
    </dbReference>
    <dbReference type="OMA" id="TATHEHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2081" mass="221002" checksum="1E34911BCAA59777" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC47</accession>
    <name>A0A1E7NC47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558043.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000326.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1723"/>
    <dbReference type="EnsemblBacteria" id="ARF80212">
        <property type="protein sequence ID" value="ARF80212"/>
        <property type="gene ID" value="B6264_15995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38269">
        <property type="protein sequence ID" value="OEV38269"/>
        <property type="gene ID" value="HS99_0022275"/>
    </dbReference>
    <dbReference type="OMA" id="VEGPRQW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="35275" checksum="FD3AE967424DDC4B" modified="2017-01-18" version="1">MALIELQDVHRTFTVRARTGRFSRVRREVRAVDGLSFTVEAGECVGYIGPNGAGKSTTIKMLTGILVPSSGRLRVAGVDPARERVALARRIGVVFGQRTTLWWDLPLRDSFELARRIYRIPDRRYRENLGRCVELLDLGGLLDTPVRQLSLGQRMRGDLAAALLHDPQVLYLDEPTIGLDVVSKGKVREFLREVNRDRGTTVLLTTHDLTDIEQLCGRVMVIDHGRVVHDGGLDGLHAAGRSERTLVVDLAEARPPIEVAGARVVKVEGPRQWLAFPARESAAPIVAEVAARYPLVDLSVREPAIEDVIARMYAEVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC62</accession>
    <name>A0A1E7NC62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387330.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000825.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3036"/>
    <dbReference type="EnsemblBacteria" id="ARF79726">
        <property type="protein sequence ID" value="ARF79726"/>
        <property type="gene ID" value="B6264_13160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38063">
        <property type="protein sequence ID" value="OEV38063"/>
        <property type="gene ID" value="HS99_0022940"/>
    </dbReference>
    <dbReference type="OMA" id="FREDHVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="18155" checksum="6B88F9C7DE1E92D7" modified="2017-01-18" version="1">MPITDDIKKTLTDPTPLYALAGAGDLAYEKLREVPGRVEALAADRQAAQDRATARLHEAQELLAGAPAKVSEAVTAFPTDLKVLQERAQDFALQQVARALELAVRAKETYDELAERGKVVVDKARPQNTPDTEAVDSADEPVRGELVDDAEAPAPQKSAKARKGGADASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC91</accession>
    <name>A0A1E7NC91_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283996.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4151"/>
    <dbReference type="EnsemblBacteria" id="ARF80161">
        <property type="protein sequence ID" value="ARF80161"/>
        <property type="gene ID" value="B6264_15675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38316">
        <property type="protein sequence ID" value="OEV38316"/>
        <property type="gene ID" value="HS99_0022600"/>
    </dbReference>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="536" mass="58777" checksum="F9B0FEED1FDE45E3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU5</accession>
    <name>A0A1E7NCU5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288370.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3096"/>
    <dbReference type="EnsemblBacteria" id="ARF82100">
        <property type="protein sequence ID" value="ARF82100"/>
        <property type="gene ID" value="B6264_27370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38501">
        <property type="protein sequence ID" value="OEV38501"/>
        <property type="gene ID" value="HS99_0021675"/>
    </dbReference>
    <dbReference type="OMA" id="CHLGFVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24249" checksum="0B6A636D4A6519C4" modified="2017-01-18" version="1">MSTTPTNTGDTSYSRTPRTTPTRYKDRATWEKEAIHAILDEAYVCHLGFVADGAPVVLPTVFARVGSRLYVHGSTGSRPMRGASDEQGMQVCVTVTHVDALVLTKSAFNHSVNFRSVVAHGTAYQVTDPEELDVALAALVDQVVPGRSGGIRPANPKELAATAVIRLELDEVSAKTRSDGANDDPEDADLPHWSGIVPVTTVHGTPEPYDRNIPLPAHMRRFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW7</accession>
    <name>A0A1E7NCW7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554982.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000583.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3086"/>
    <dbReference type="EnsemblBacteria" id="ARF82107">
        <property type="protein sequence ID" value="ARF82107"/>
        <property type="gene ID" value="B6264_27420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38494">
        <property type="protein sequence ID" value="OEV38494"/>
        <property type="gene ID" value="HS99_0021625"/>
    </dbReference>
    <dbReference type="OMA" id="CPFVNGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25165" checksum="F6EAE68E725D50A0" modified="2017-01-18" version="1">MNSSEAEVPEPTTADRVHSLLSATSSLTVRALGEHHDLDTPISVHGSRLRLRAPLDAPLTAAAAAAADGLAVVLDVTDVSPVAVRDRIRARLTLAGRLHLAHLADDGLSVHLRVDVAHAVLATPYGTGALTAADLALATPDPLARHEAALLTHLADDHADALELLTGLLDPALLTHHPAVRPLALDRHGLVLRLDHSHGHRDVRLVFPEPACDTEDFGHRMHELLTAAQHGLPVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY3</accession>
    <name>A0A1E7NCY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288340.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3111"/>
    <dbReference type="EnsemblBacteria" id="ARF82090">
        <property type="protein sequence ID" value="ARF82090"/>
        <property type="gene ID" value="B6264_27295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38514">
        <property type="protein sequence ID" value="OEV38514"/>
        <property type="gene ID" value="HS99_0021750"/>
    </dbReference>
    <dbReference type="OMA" id="IAVGVVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="22912" checksum="252F13AC161DD4E9" modified="2017-01-18" version="1">MSSTGDDAAVGGLCAVHMPRTARTVSDLPRVGRFPAVQPGQPAIERLAPTSELLGFRGPTACAAAGITYRQLDYWARTGLLEPSVRTAYPATSQRLYSFRDVLLLKIVKRLLDAGVSLQNIRVAVAHLQSADQADLTGLTLMCDGATVYECTTPQQVVDLLKGGQGVFGIAVGAVWQELELTLGRLHAERTDTGETLVGNDPADELAQRRNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND28</accession>
    <name>A0A1E7ND28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C(11)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0020250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281213.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene629"/>
    <dbReference type="EnsemblBacteria" id="ARF77626">
        <property type="protein sequence ID" value="ARF77626"/>
        <property type="gene ID" value="B6264_00665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38599">
        <property type="protein sequence ID" value="OEV38599"/>
        <property type="gene ID" value="HS99_0020250"/>
    </dbReference>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26594" checksum="AC5DCED0E16E3E05" modified="2017-01-18" version="1">MTVYFIGAGPGAADLITLRGQRVLARAEVCLYAGSLVPRELLEECPPGARLIDTAQLNLDQITAELVAAHRAGQDVARLHSGDPSVFSAVAEQMRRLDAAGVPYEVVPGVPAFAAAAAALKRELTVPTVGQTVILTRIAKRATPMPEGEDLATLGRSGALLVLHLAAGYVDDVVEQLLPHYGADCPAAVVAMASRPDELVLRGTLADIAGQVKEAGVVRTAVIIVGRTLAAEQFRDSHLYSADRERPHQPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND41</accession>
    <name>A0A1E7ND41_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551516.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene679"/>
    <dbReference type="EnsemblBacteria" id="ARF77588">
        <property type="protein sequence ID" value="ARF77588"/>
        <property type="gene ID" value="B6264_00405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38564">
        <property type="protein sequence ID" value="OEV38564"/>
        <property type="gene ID" value="HS99_0019990"/>
    </dbReference>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="38"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="507" mass="54161" checksum="99BA01DC68509755" modified="2017-01-18" version="1">MTVYQPPGTPGSIVAYRSRYDHWIGGGWAPPVRGEYFGNPTPVTGEVFTEVARGTAEDIEAALDAAHAAAPAWGRTSAAERAQVLLRIADRMEAHLEQLAVAESWENGKPVRETLAADLPLAVDHLRYFAGALRAQEGSLSQLDEDTVAYHFHEPLGVVGQIIPWNFPILMAIWKLAPALAAGNAVVLKPAEQTPASVLLLAELTADLVPPGVLNVVTGFGEEAGAPLAASKRVRKLAFTGETGTGRLIARAAADNLIPATLELGGKSPNLFFADVAADDDAFYDKAVEGFAMFALNQGEVCTCPSRALIESPVYERLLGDGLGRVRAMRQGDPLDTETQVGAQASAEQLKKILSYFEIGQAEGAKVLVGGERADLGGPLAGGYYVTPTVFEGVNSMRVFQEEIFGPVVSVTRFDGFDEAVALANDTQYGLGAGVWTRNINTAHRAGRAIQAGRVWTNCYHAYPAHAAFGGYKNSGIGRENHKALLEHYQQTKNLLVSYSPDAVGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND44</accession>
    <name>A0A1E7ND44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene625"/>
    <dbReference type="EnsemblBacteria" id="ARF77629">
        <property type="protein sequence ID" value="ARF77629"/>
        <property type="gene ID" value="B6264_00685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38601">
        <property type="protein sequence ID" value="OEV38601"/>
        <property type="gene ID" value="HS99_0020270"/>
    </dbReference>
    <dbReference type="OMA" id="NYMVQDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="513" mass="55940" checksum="481BB5C86BC40748" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDJ8</accession>
    <name>A0A1E7NDJ8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="9" type="ORF">HS99_0019080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291270.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7368"/>
    <dbReference type="EnsemblBacteria" id="ARF81185">
        <property type="protein sequence ID" value="ARF81185"/>
        <property type="gene ID" value="B6264_21815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38777">
        <property type="protein sequence ID" value="OEV38777"/>
        <property type="gene ID" value="HS99_0019080"/>
    </dbReference>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="38323" checksum="933ECE5FD0943934" modified="2017-01-18" version="1">MTDTTVRIHVGGSAGHDPYDVLIGHQLLGELAPLIGTRAKRVAIIHPEALAATADAIREDLAGEGYEAIALQVPNAEEAKSAEVAAYCWSVLGQTGFTRSDVVVGLGGGATTDLAGFVAATWLRGVRWISMPTTLLGMVDAAVGGKTGINIAEGKNMVGAFHPPVGVLADLGTLETVPRHDYVSGLAEVIKCGFIADPAILDLIEADPEGAKSPAGPHTVELIRRAIQVKADVVSGDLKESGRREILNYGHTLGHAIERNERYKWRHGAAISIGMVFAAELGRLAGRLDDETADRHRTVLASVGLPLSYRADAWPKLLDAMKIDKKSRGDLIRFIVLDGLGKTSVLEGPDPSLLVAAYAEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE75</accession>
    <name>A0A1E7NE75_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4386"/>
    <dbReference type="EnsemblBacteria" id="OEV39016">
        <property type="protein sequence ID" value="OEV39016"/>
        <property type="gene ID" value="HS99_0018095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25255" checksum="D5B21E788F3A05BA" modified="2017-01-18" version="1">MAPETHATPESCDHRLLRLEQAESPLIAQLAAAIGHLRTAGEHTDPDQNLAHYPGRTARDLTSWIGGNVQMITELLVPLIAPHTRVEITSYGVLHQDPPLGDALTLDLTTALRNPPEDPEVREVMLHSSGLDQVVYEYVLATPGAVEIAERTVLRVLAQAAALPGQPVALHVYCRGGKHRSVVLARKVAELLRGVGAAVAVTHRHVHLPVVENGLAVGTGSSAEISDDPTGAWTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU1</accession>
    <name>A0A1E7NEU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39219">
        <property type="protein sequence ID" value="OEV39219"/>
        <property type="gene ID" value="HS99_0000365"/>
    </dbReference>
    <dbReference type="OMA" id="MFARYVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="20615" checksum="EEC8BEFB43818B0B" modified="2017-01-18" version="1">MDSGGRTETVELRFTPTAGDFRAAFAARARGTVAGRAARRTTNLLAGCAAFTGTGAVLTAAANGVVRPPAVVMLVLALLVLGMPWLRGWQARRLAAGKGEFRVLVDAAGMTVTNAVSSTVLGWRELPYHLETPELFVLLGGNERTPTLTVLPKRGTDDSGRLGELIARHSSALPQELPTAFPTAFPKASPKAPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF62</accession>
    <name>A0A1E7NF62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550263.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3653"/>
    <dbReference type="EnsemblBacteria" id="OEV39312">
        <property type="protein sequence ID" value="OEV39312"/>
        <property type="gene ID" value="HS99_0000940"/>
    </dbReference>
    <dbReference type="OMA" id="SRWQFGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="53283" checksum="C77D60BA68802411" modified="2017-01-18" version="1">MTTTPAPGAAAPARPADPNVFERLRPVADAVLYEGYLLYPYRRSSAKNRVRWQFGVLAPRPWVEAGGPVAETVAGSAESWYQQTECLAEAAPGAVLHVRVRYLQVQHKSVQRRTADGRYEPVESLQAPDAVHLSFEEAVPRETDLVLPLAELLAGDRTFEVGAPGGEQTEELPDADGRAVRRCHPVEARTTVHAEPLDGRLYRLRVRTENTGRQVGPGATREEALRHTLVATHTFLGGSGLSFLSLTDPPERAAEHARACRNLHTYPVPADADRAVLSSPIILPDQPRIAPESPGDLHDAGEIDEILSLRTMLLTDEEKREARATDRRAAEILDRVDTMPPEVFTRLHGAIRSLRPAGRPEPGARPEPAARAPWWEEGGDDGLAPATDRVLVDGVSLARGSRVELRPHGRGSDAQDMFLAGRTAEVAAVFHDVDGSVHLAVTVDDDPGAELHGWYGRYRYFRPDEVRPLGTTPDETRSDGHHRTPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFB4</accession>
    <name>A0A1E7NFB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556012.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1538"/>
    <dbReference type="EnsemblBacteria" id="OEV39364">
        <property type="protein sequence ID" value="OEV39364"/>
        <property type="gene ID" value="HS99_0001255"/>
    </dbReference>
    <dbReference type="OMA" id="DCPWIVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="24958" checksum="C44B3EB35E73E45B" modified="2017-01-18" version="1">MQQPSPAPRKATGRPPRISREEVVDTARRIVTEEGVERLTMRRLASEVGSTPMALYHHVRNKEELLVLLLDDHAARTLRPTELPSEPRERVVAAAAAIHEALCACPWIVEVLTADDLMSTHALWFVEQLVDGLVDCGLSLERAVQGYRAIWYYTAGEIVVRTTAARRRAGNDRPTYREQVFAGLDADEYPRLAQVADRWEPLTAQDTYRDGLRALVAGLLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFB8</accession>
    <name>A0A1E7NFB8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286034.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000106_gene5842"/>
    <dbReference type="EnsemblBacteria" id="OEV39400">
        <property type="protein sequence ID" value="OEV39400"/>
        <property type="gene ID" value="HS99_0001470"/>
    </dbReference>
    <dbReference type="OMA" id="KGCFTIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C" evidence="2">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20966" checksum="8EB88B0448563036" modified="2017-01-18" version="1">MPRPREFDPETVLNQAMLRFWERGYRATSIEDLVKATGVKPGSIYSAFPGGKHALFVKSLERYSKLVVPRKLGELEAPGASVAEVRGYFDGLVRDLLSPEGRQGCLLVNTAIEKAAEDDEAAAVVRGHLARLERCMTRALENAVRRGEVRASLDASGSAKLLVATCQGLMVVGKANPDEAVLRAIVDNAFAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD4</accession>
    <name>A0A1E7NFD4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39382">
        <property type="protein sequence ID" value="OEV39382"/>
        <property type="gene ID" value="HS99_0001365"/>
    </dbReference>
    <dbReference type="OMA" id="VVLWLAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="16553" checksum="E288354ABB7E3AE3" modified="2017-01-18" version="1">MTQPPHDEPTASSPEELRAQVERTRAELGETVQALTAKAEEKAAEVKAQTAAKAGELKEQATLKAAELKARAADVAHQAQDRLPDPVRDKAAQAAGQARAKAAEVGHLWEEKAPEPVREKTARGAQLARDNRKVLVAAACVAVVLWLACRRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG18</accession>
    <name>A0A1E7NG18_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="3">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the degradation of xylan and is a key enzyme in the complete degradation of the plant cell wall. It has a specific arabinofuranose-debranching activity on xylan from gramineae. Acts synergistically with the xylanases and binds specifically to xylan. From small arabinoxylo-oligosides (ranging from arabinoxylotriose to arabinoxylohexaose), it liberates arabinose and, after prolonged incubation, the purified enzyme exhibits some xylanolytic activity as well.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385776.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2803"/>
    <dbReference type="EnsemblBacteria" id="OEV39659">
        <property type="protein sequence ID" value="OEV39659"/>
        <property type="gene ID" value="HS99_0003045"/>
    </dbReference>
    <dbReference type="OMA" id="STYRWNS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199105" description="Alpha-L-arabinofuranosidase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="38"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="50481" checksum="5C72AFBA7388F0AD" modified="2017-01-18" version="1">MRERRSCLRRPHKMLVAVVAAVAALAAVLVAGPAQAATSGALRGTGSGRCLDVANASRTDGAPLQVYDCWNGANQQWTLTPDNQLTVYGDKCLDVPGHATAAGTRVQIWTCTGAANQQWRVNADGTVVGVESGLCLDVAGAGTANGTAVDIWQCNGGSNQSWTGLSSSAPPGGSCALPSTYRWSSTGALAQPANGWVALKDFTDVVYNGKHLVYASNVSGSSYGSMAFAPFTNWSDMASAGQTGMNQNAVAPTLFYFAPKNIWVLAYQWGQWPFIYRTSSDPTNPNGWSAPQPLFTGGIPGAAPIDQTLIGDDQNMYLFFAGDNGSIYRASMPIGNFPGNFGSSYTTVMSDSVKNLFEAPQVYKVKDRNQYLMIVEARGANEQRYFRSFTATSLNGQWTPQAASESSPFAGKANSGATWTDDISHGDLVRNNPDQTMTIDPCNLQLLYQGKSPAATGPYDQLPWRPGLLTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG51</accession>
    <name>A0A1E7NG51_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285896.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5096"/>
    <dbReference type="EnsemblBacteria" id="OEV39473">
        <property type="protein sequence ID" value="OEV39473"/>
        <property type="gene ID" value="HS99_0001900"/>
    </dbReference>
    <dbReference type="OMA" id="NGPWAPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25832" checksum="D89313CDE36EACA9" modified="2017-01-18" version="1">MAVYVYSITAAGHPHDLTGLDTVGPVPAALRSLRAGPLAAVVSDAPAELRPKRRDLMAHQAVQERLVADGAVLPLRFGLTAPDDDAVRAALDQHREEYLQRLSHLEGCAEYHIKAAVEEDALLRQILRESPRARQLNDDIKAGNSNPELPLALGELVTQEVLARQQALAAGITEALRPHTREELASEPTGNDFLNISFLVDQEHRELFLTAEKGLADELGADCDVRLYGPLPAYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI3</accession>
    <name>A0A1E7NGI3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7555"/>
    <dbReference type="EnsemblBacteria" id="OEV39821">
        <property type="protein sequence ID" value="OEV39821"/>
        <property type="gene ID" value="HS99_0001710"/>
    </dbReference>
    <dbReference type="OMA" id="RCGRTIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="19752" checksum="F9882BDAA27443E5" modified="2017-01-18" version="1">MSDTGRIILDTTLDPYDPDQVWISLTRGEARQLAGMLLRQAAAVDRPLAPRAGRIEIDPVAGDLYAVGVRSHALAVGQPLDAGGADTAPTPVELCASTLASCTAHYTGGYLDRHGFSRDGLHVTAGFTVSQDRPARIASVSVEITALGLPPDREAGLLAVVRHCTVKNTLDHPPAVRVSLNGSPKASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP7</accession>
    <name>A0A1E7NGP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3571"/>
    <dbReference type="EnsemblBacteria" id="OEV39795">
        <property type="protein sequence ID" value="OEV39795"/>
        <property type="gene ID" value="HS99_0000535"/>
    </dbReference>
    <dbReference type="OMA" id="GEAGFHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="17632" checksum="DE3E07FE32E7F768" modified="2017-01-18" version="1">MAAVNADPDVMRWIGDGRVQTPEETRRAVERIERTWDTEGFGLFAVELRETGELAGFTGLAVPLFLPEVLPAVEIGWRLGRSFWGRGIATEAATAALRFGFEACGRDRIISIARIGNTASERVMAKLGLRPERETTVPGNGTAVRVHELTRADYLARPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGQ9</accession>
    <name>A0A1E7NGQ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2888"/>
    <dbReference type="EnsemblBacteria" id="OEV39867">
        <property type="protein sequence ID" value="OEV39867"/>
        <property type="gene ID" value="HS99_0003465"/>
    </dbReference>
    <dbReference type="OMA" id="RGTQIAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="42484" checksum="56EB37DB27A5953B" modified="2017-01-18" version="1">MDATATADPARPGRRGGGGSGGATAFWRYWTASTVSRLGDQVTTVALPLIAVVTLHASAFEVGLITGAAYLAWLVIGLPAGVLVQRLPLRGTQVAMDLVRAAAVASIPLAAALGVLGLTQLVVVALLVGFASVLFDVGNSTFLPTVVPKEQLTARNSLVSGSIAATDLAGPSLGGVLVQLVGGAASMLLDSASYVVSAALLGSLPQAGQPAARPSGGAGMREQIREGWRFVARHPVIRPCVADATAVNFVCGGLMTLTPVFLVRTLDAPAAAVGALMATGGLGSLLGAAATPRLVSRFGGGPSLRRAAVVSTVFALLLPLAGSGWGTLLFALGNAGFSAGVVVTSIVTRTHRQTHTPPELLSRVMATVRFVSWGAIPVGALAAGAAAAAWGPRTALLLVAIVSVASPAILLASPVRRMRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH99</accession>
    <name>A0A1E7NH99_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5049"/>
    <dbReference type="EnsemblBacteria" id="OEV39833">
        <property type="protein sequence ID" value="OEV39833"/>
        <property type="gene ID" value="HS99_0002130"/>
    </dbReference>
    <dbReference type="OMA" id="YMYNMAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="420" mass="44130" checksum="F0A6852BD5AA4CA5" modified="2017-01-18" version="1">MVRALVGGAAVLAAGGASAWYGLAGDAQATGDPEGVGPVTLATGRDTTHYLRGLLADWNAEHPDQPAELVELPEAADEVHAQLAGELSTGGSRFDVLNLDVVWTAEFAARRWTVPLDESDFALGSFLPPVVRTGRYDGRLYAVPFVANAALLYYRSDVLAAAGEQPPTTWPELVRQARTLAPAHGLSGYAGQLSPYEGLAVNALEAIRSAGGDLLAGDGTVVVDSPQALAGLEFLAGGVRDGWIPREVLGYQEEESRAAFGRGGLLFLRNWPYVYHAVGAAGSPVEGRFGVVPLPGPNGPGSGVLGGSGLAVSRFSRHQRTARALIGYLTSRRAQYRVLTDGGLPPVWADLYADPDLTARFPYLPVLRTAILAAGARPGVPQYQQLSLAFSETAFEVVSGRRTAEAALPRLAADLRAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV31</accession>
    <name>A0A1E7MV31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279693.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000687.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2995"/>
    <dbReference type="EnsemblBacteria" id="OEV32286">
        <property type="protein sequence ID" value="OEV32286"/>
        <property type="gene ID" value="HS99_0016365"/>
    </dbReference>
    <dbReference type="OMA" id="GMYRIAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13241" checksum="F004FA8795C047A7" modified="2017-01-18" version="1">MSNPDALLVDIAAMVESERSNQMPLTVVVPGAVITGRLAPERLWHERVAEVLAASDHLKPFATLFETSAADTAPPASRPTHLHLHVARILQGSFGLPHTGGMYRIAISDVSSWTVGDLSYSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV32</accession>
    <name>A0A1E7MV32_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289873.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6862"/>
    <dbReference type="EnsemblBacteria" id="OEV32290">
        <property type="protein sequence ID" value="OEV32290"/>
        <property type="gene ID" value="HS99_0016385"/>
    </dbReference>
    <dbReference type="OMA" id="REFMSGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="36062" checksum="05F353FBBEED5D02" modified="2017-01-18" version="1">MRGTVIHGPGDIRLETLDDPKILHPTDAVIRTALTCVCGSDLWPYRGVDTVAGPSPMGHEYVGFVEEVGSEVTGLRPGQFVVGSFATSDNTCPNCRNGFTSNCLHREFMSTCQADYVRIPNAQGTLVATEEVPGEEYWPGLLAVSDVMGTGWWAADAAEVKPGSTAVVVGDGAVGLCGVIAAKAMGAERIIAMSRHESRQRLAREFGATDLVTERGEEGVARIRQLTDGIGADSVLECVGTAEAMQQALRSARPGGNVGFVGVPHGVAVDGQELFFSHVGLRGGPAPVRRYLPDLIDHVLTRRIDPGKVFDLTLPLEQVAEGYRAMDERRAVKALLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV68</accession>
    <name>A0A1E7MV68_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6914"/>
    <dbReference type="EnsemblBacteria" id="OEV32326">
        <property type="protein sequence ID" value="OEV32326"/>
        <property type="gene ID" value="HS99_0016620"/>
    </dbReference>
    <dbReference type="OMA" id="ERIYMMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="115"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="39851" checksum="4F043ECF23E1DE04" modified="2017-01-18" version="1">MKVLVAGAGIGGLCLAQGLVRAGIDVRVFEREPAADSRYQGFRIGLDGPGIAALRECLPPRLHPLLEAVTGPLAGARRLVDRQLNELRHLSATVDGTAADRHVLRQLLLAGLGDRVEFGRAVTGYRERADGRAEARLADGGSAVGDLLVGADGVGSAVRRQLLPGAEVVDVPGNALLGRTPLTERLAALVPGSGTLVHGSGLNLLVGRMEFRRPPRLAAAELAPEVELPDAESYLRWVAMLPEPLGPEPGEWAQVRDRLLGLLDGWHPDLVELVRQSDTGNSSPLTIRYAEPVSHWGTGPVTLLGDAIHAMPPSAGQGANTAFRDAALLCRSLAAVHRGEAELTDAVEDYELQMLDRGFAAVAMGLDRLSEFTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV87</accession>
    <name>A0A1E7MV87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553810.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32346">
        <property type="protein sequence ID" value="OEV32346"/>
        <property type="gene ID" value="HS99_0016730"/>
    </dbReference>
    <dbReference type="OMA" id="HGHVLLC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10762" checksum="302F805D22D2AF14" modified="2017-01-18" version="1">MTGRRAALGWTFLTSHARVVVQIARDPGVRVRDIAARCLLTERAVQRIIVDLEEAGYLTHERRGRVNHYRVITGKQLRHPADAGPTLAELLAALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG6</accession>
    <name>A0A1E7MVG6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0017130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000107_gene5833"/>
    <dbReference type="EnsemblBacteria" id="OEV32414">
        <property type="protein sequence ID" value="OEV32414"/>
        <property type="gene ID" value="HS99_0017130"/>
    </dbReference>
    <dbReference type="OMA" id="HEDAGHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="21858" checksum="39916A4FFBFC0A21" modified="2017-01-18" version="1">MRELPALLHLPTHDGEHPELRSAVELLGAELATARPGAQLAAPALIDLLLVYLVRAWTTRPEAGGWGAALADPVVAAALAAVHTNPAHPWNAETLAARAGVSRATLNRRFTALTGRPPMAYLTWWRMTRAAALLRRGTDPLETVARQVGYSSGYALSHAFTRQFGTTPGRYRTATATATDETVGANTPAHAAAKAAQPGHVHEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW57</accession>
    <name>A0A1E7MW57_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554918.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3156"/>
    <dbReference type="EnsemblBacteria" id="ARF78295">
        <property type="protein sequence ID" value="ARF78295"/>
        <property type="gene ID" value="B6264_04620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32668">
        <property type="protein sequence ID" value="OEV32668"/>
        <property type="gene ID" value="HS99_0015465"/>
    </dbReference>
    <dbReference type="OMA" id="DPRPWEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="397" mass="42938" checksum="C1A3573D13AD6BAD" modified="2017-01-18" version="1">MTVETRPTPIYGPVFAADPQLVYERLRRHGAVAPVEIAPGVEALLVTDYQAALDLLRDTDTFSKDSRAWQATVPPDSPLLPVLGYRPTALFSDGATHARYRAVITDGLALFEPHRLQRQVAEAAHQLIDRFAGVGHADLIAEYARQLPAFVLTTWFGVPEEQHADVVAAITGLIESTARAGAAYGKLVAVVTAMVAERRERLRHDLASWFVTHPVGLDDDEVIRQITLTLIAGHEPTTNLIGNALLRLLTDARYAGSLFGGAMTAHQAIDEVLWHEPPMANLSAHYPRYDITFHGREIKAGSLVLVSYAAANSQAAPPTDGGELRSGESAHLAWAAGPHACPARDPALLIAITAIEQLTSRLSDLELATPAGELLWRPGPFHRALVHLPVRFAPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC4</accession>
    <name>A0A1E7MWC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285530.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000387.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7823"/>
    <dbReference type="EnsemblBacteria" id="ARF78215">
        <property type="protein sequence ID" value="ARF78215"/>
        <property type="gene ID" value="B6264_04160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32742">
        <property type="protein sequence ID" value="OEV32742"/>
        <property type="gene ID" value="HS99_0015925"/>
    </dbReference>
    <dbReference type="OMA" id="TRWIDDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="38771" checksum="7FDD9853A6B27F13" modified="2017-01-18" version="1">MSDGAVLHVRGRVLVGPEEVRDELWVVDGRVSFTRPPTVEDVRTVTGWVLPGLVDAHCHVGLDAHGAVDAETSEKQALTDRDAGTLLIRDAGSAADTRWIDEREDLPRIIRAGRHIARTRRYIRNYAHEIEPGDLAAYVRAEARRGDGWVKLVGDWIDRERGDLAACWPGDALAEAIAAAHEEGARVTAHCFAAESLPDLLTAGIDCVEHATGLTEELIPAFAERGVAIVPTLVNIATFPALAAGGEAKFPAWSAHMRRLHERRYDTVGAAHDAGIPVFVGTDAGGSLAHGLVADEVAELVKAGLSPAEALSAASWGARAWLGRPGLEEGAPADFVVYAEDPRADVRVLADPLLVVLRGRPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF0</accession>
    <name>A0A1E7MWF0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="5" type="ORF">HS99_0016035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285586.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000786.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6112"/>
    <dbReference type="EnsemblBacteria" id="ARF78195">
        <property type="protein sequence ID" value="ARF78195"/>
        <property type="gene ID" value="B6264_04045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32760">
        <property type="protein sequence ID" value="OEV32760"/>
        <property type="gene ID" value="HS99_0016035"/>
    </dbReference>
    <dbReference type="OMA" id="EIHHGVA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="506" mass="53605" checksum="35B82A19AB3BD96D" modified="2017-01-18" version="1">MSTSKALLVAGTTSDAGKSVVTAGICRWLARQGVRVAPFKAQNMSLNSFVTADGAEIGRAQAMQAQAARVEPEAAMNPVLLKPGADGRSQVVLLGRPVAEVGALDYRERKPVLLERALECLADLRRRYDVVVCEGAGSPAEINLRDRDIANMGLATAAALPVVVVGDIDRGGVFAAMYGTLALLSAEDQRHVAGWFVNKFRGDARLLAPGLEMLHELTGRPVLGTLPMLPGLWLDAEDSLDLSTVVDRADGPGPLGADVLRVAVVRFPRLSNFTDVDALAQEPGVLVRWATRPEELADADLVVLPGTRATVADLAWLRERGLEPALKARAAAGLPILGVCGGYQMLARSIEDEVESRAGLVDGLGLLPTDVRFGAEKVLARPVGEAYGQRVEGYEIHHGIVAVEGGETFLDGCRVGSVWGTTWHGALENDGFRRELLREVAELAGRAFVPAPDTSFAAAREARLDRLGDLIEEHADTDALWKLIEGGVPAAGTLPFLPPGAPGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ9</accession>
    <name>A0A1E7MWQ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene74"/>
    <dbReference type="EnsemblBacteria" id="ARF80130">
        <property type="protein sequence ID" value="ARF80130"/>
        <property type="gene ID" value="B6264_15455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32867">
        <property type="protein sequence ID" value="OEV32867"/>
        <property type="gene ID" value="HS99_0039770"/>
    </dbReference>
    <dbReference type="OMA" id="GVTWVRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22391" checksum="6149E3E721B6E582" modified="2017-01-18" version="1">MPNGRYSLHDTHDHVLLGEERFSCAPGAAGWRYVSKTYAPDGRVIGSVDLTLDSRARPLRMELRAGGWQVRGGAVDGVAWVRTDAADPGGEHATEGHDRAHGFTGSSSAFLVATARMLRLREGASARVRLVAFTEPVLAPRTFDQGWLLEGVDTHETDSGPLVVERYQVADLETGEQQVVHLAGDVVLAAAGIELEELASPPNAWAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ6</accession>
    <name>A0A1E7MWZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81349">
        <property type="protein sequence ID" value="ARF81349"/>
        <property type="gene ID" value="B6264_22745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32939">
        <property type="protein sequence ID" value="OEV32939"/>
        <property type="gene ID" value="HS99_0013725"/>
    </dbReference>
    <dbReference type="OMA" id="CDEREFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11503" checksum="12E955EF6CE3FFAC" modified="2017-01-18" version="1">MTAAPSPNPRIPFDQELCGLVLGTAPRLFAVVQVCDEGREDADGWVAAWGLADHAGPTHVISLDGRARMTLPSPERALRHFTNQPGITARLVWLAQPDAAAIDRPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX97</accession>
    <name>A0A1E7MX97_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5622"/>
    <dbReference type="EnsemblBacteria" id="ARF81484">
        <property type="protein sequence ID" value="ARF81484"/>
        <property type="gene ID" value="B6264_23515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33068">
        <property type="protein sequence ID" value="OEV33068"/>
        <property type="gene ID" value="HS99_0014485"/>
    </dbReference>
    <dbReference type="OMA" id="ELETEYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046156">
        <property type="entry name" value="DUF6158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19655">
        <property type="entry name" value="DUF6158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10646" checksum="F3CD16E5EE74566F" modified="2017-01-18" version="1">MRHVNDPHIRPEGISPHALGNDTLLHELEQLHRTRHETFLYGSEEALKRHTLRTGELEAEYLHRFPGRHVTAARTRAGARAREAAARVESLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ5</accession>
    <name>A0A1E7MXQ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557602.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7098"/>
    <dbReference type="EnsemblBacteria" id="OEV33216">
        <property type="protein sequence ID" value="OEV33216"/>
        <property type="gene ID" value="HS99_0039205"/>
    </dbReference>
    <dbReference type="OMA" id="GMQGAWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="525" mass="55871" checksum="E11AF33D9511E18E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR5</accession>
    <name>A0A1E7MXR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290304.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000088.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7111"/>
    <dbReference type="EnsemblBacteria" id="OEV33226">
        <property type="protein sequence ID" value="OEV33226"/>
        <property type="gene ID" value="HS99_0039265"/>
    </dbReference>
    <dbReference type="OMA" id="RWQGPSF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15188" checksum="E558857111A013DF" modified="2017-01-18" version="1">MTDNIFASSVFFSLTIGGNDLGEFTTCSGLGAQVEIEQYAEGGNNGFSWQLPGRITWSNITLTRAVTADSAKIARWLGEIVRKVEPKDGEIVALRPDLSRIIGWQVLGIVPVRWEGPSFDPASSQAAVESLEIAHAGLRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXW1</accession>
    <name>A0A1E7MXW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene528"/>
    <dbReference type="EnsemblBacteria" id="OEV33259">
        <property type="protein sequence ID" value="OEV33259"/>
        <property type="gene ID" value="HS99_0039020"/>
    </dbReference>
    <dbReference type="OMA" id="TGMMTHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="19286" checksum="33019C9AD422C8DB" modified="2017-01-18" version="1">MKVARPVLRGDSAPRGQGPTRHTYTRGVMELTGWREALDAAAALLARARSAGATVIHVINDGGPGTPYDVRAEIGQIHPDVAPVEGERVVVKQAPDAFVGTDLGALVDVAGHQDVVIAGFMTHMCVAFTTAGAFLRGNRPTVVADACATRPLRSGATELTAAQIHRGALATVGDLYGVVAESAADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE1</accession>
    <name>A0A1E7MYE1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555527.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80556">
        <property type="protein sequence ID" value="ARF80556"/>
        <property type="gene ID" value="B6264_18040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33452">
        <property type="protein sequence ID" value="OEV33452"/>
        <property type="gene ID" value="HS99_0012820"/>
    </dbReference>
    <dbReference type="OMA" id="NWHEAED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="20437" checksum="120AC9CB87353BE8" modified="2017-01-18" version="1">MTGIRLVDEAFDDGFTQFVKEVRPRLRRNAFVLVGDWFEADDLVQRTLIAVYRRWDRLEQRDDLNAYTRTVMVRQFISERRGHRWSRELIQNPLPEPEPAPEDVACVGDRVLLLGALAELAPRQRSLVFLRYWEDLSIEETARTVGCSPATVRSSTSRTLRILRERLGALYSDDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ77</accession>
    <name>A0A1E7MZ77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288013.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7690"/>
    <dbReference type="EnsemblBacteria" id="ARF78555">
        <property type="protein sequence ID" value="ARF78555"/>
        <property type="gene ID" value="B6264_06185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33755">
        <property type="protein sequence ID" value="OEV33755"/>
        <property type="gene ID" value="HS99_0038085"/>
    </dbReference>
    <dbReference type="OMA" id="AAVTWEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="30688" checksum="8E16DD003B80012A" modified="2017-01-18" version="1">MIIGLVTAVAASACYGTGSVLQAVGSRRSAREEEARGATTSTTEHGGPSLSSTAKAAVTWEFILGTVLDLIGFGLGALAARLLPLFLSQTIISANLVITAVLSIKLLGIRLRQLEWASIGVLCSALVLLAVSAGPEGGHHASTAFHWGLLIITTVLLAGGSLLVRRMGSKGAIVAGLLSGLGFGGLGVGVRILNGLDPFQLGTLLSDPALYAVLVGGLGGMYIHTVALQIGSVNGATAALVVGETVLPGAVGVLWLGDSSKAGLGWLGVAGFLLAVVSAVGVAYFGQSEHGAPGEASAEHPELARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ92</accession>
    <name>A0A1E7MZ92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3777"/>
    <dbReference type="EnsemblBacteria" id="ARF78397">
        <property type="protein sequence ID" value="ARF78397"/>
        <property type="gene ID" value="B6264_05210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33770">
        <property type="protein sequence ID" value="OEV33770"/>
        <property type="gene ID" value="HS99_0037815"/>
    </dbReference>
    <dbReference type="OMA" id="EKTVFNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="24647" checksum="0DB02C96EA63F021" modified="2017-01-18" version="1">MATHHGFDLGPHRDLDALPLRERKKIQTGIRIFRTAVVLFAERGFDQVSVAEIAAAAEVSKMTVFNYFPTKEDLVMGPMEQHLDEPARAVRDRAPGTSAVVALREHFLAALERKDPATGLNDDRVVLDVIRLIHATPALAVRATAGFGQQAQTLLAAELCAQDPAHDELTARVAAAQLLAVRLTLIGGNHRRMLDGESADAALPAALDEARRAFASVEHGLGDYGAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF5</accession>
    <name>A0A1E7MZF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557942.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80394">
        <property type="protein sequence ID" value="ARF80394"/>
        <property type="gene ID" value="B6264_17080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33814">
        <property type="protein sequence ID" value="OEV33814"/>
        <property type="gene ID" value="HS99_0037705"/>
    </dbReference>
    <dbReference type="OMA" id="ERLCWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045929">
        <property type="entry name" value="DUF6348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19875">
        <property type="entry name" value="DUF6348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="27659" checksum="9AA471FA759FBDC9" modified="2017-01-18" version="1">MGPQERLAVIQRCVIREMARLGQVFLPDGEVVRGPGSTAVAVREHPGDDGGAGHVDLGFVLQLGRADAPVVWDCAAGLGKTEEEKLANAVKMWATTTASVLVELADGHGVHADRPDLPQLPGWRAVQGPAAVFGFGNEHLAAWLAEHRVLPALAPALRGELAGPGPVGVKLFLGGKAGDDVAEVRVDGEVSEAASAALRALDWPRGERLCWARLFVLLTAERAAPFAAAPAGAVAPVPVRPPAPAAARPRGLFARWREARRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH0</accession>
    <name>A0A1E7MZH0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4391"/>
    <dbReference type="EnsemblBacteria" id="ARF80309">
        <property type="protein sequence ID" value="ARF80309"/>
        <property type="gene ID" value="B6264_16595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33850">
        <property type="protein sequence ID" value="OEV33850"/>
        <property type="gene ID" value="HS99_0037575"/>
    </dbReference>
    <dbReference type="OMA" id="VFDAEQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23706" checksum="12983CC96F604A45" modified="2017-01-18" version="1">MRVVLAEDLYLLREGLIRLLEAHGFTIAAAVETGPELLEALLTHRPDVAVVDVRLPPTLTDEGLQAALKARREIRGLPVLVLSQHVQQLYARELLADGTGGIGYLLKDRVFNAAQFIDAVRRVAAGGTAMDPDVIAQLMQTTSRRPGPLLGLSPREREVLELMAEGCSNSAIAARLSVSDGAVAKHIANIFSKLELAPDEDANRRVMAVLAYLNGTAGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ0</accession>
    <name>A0A1E7MZQ0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="10" type="ORF">HS99_0038370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557089.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000169.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4289"/>
    <dbReference type="EnsemblBacteria" id="ARF80355">
        <property type="protein sequence ID" value="ARF80355"/>
        <property type="gene ID" value="B6264_16840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33693">
        <property type="protein sequence ID" value="OEV33693"/>
        <property type="gene ID" value="HS99_0038370"/>
    </dbReference>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26280" checksum="1E83029411375271" modified="2017-01-18" version="1">MTLRVAVIGAKGRIGSEAVKAVEAAPDLELAAALGRGSKLEELTESGAQVAVELTHPDSVMGNLDYCVHNGIHVVTGTTGWTDERLATVRGWLADAPDLGLLIAPNFSIGAILGMKFSQIAARYFESVEVVELHHDRKADAPSGTATRTAQLIAAARAEAGRPKQQDPTTHSLPGARGADVDGVPVHAVRLRGLLAHQQVMFGDTGETLTIRHDSLHHSSFMPGILLGVRKVVETPGLTFGLEHFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ2</accession>
    <name>A0A1E7MZQ2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0010550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1848"/>
    <dbReference type="EnsemblBacteria" id="OEV33914">
        <property type="protein sequence ID" value="OEV33914"/>
        <property type="gene ID" value="HS99_0010550"/>
    </dbReference>
    <dbReference type="OMA" id="WKHIKLT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023107262" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="222"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="371"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="56668" checksum="D0B0D83D597C4472" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0C9</accession>
    <name>A0A1E7N0C9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2190"/>
    <dbReference type="EnsemblBacteria" id="ARF82557">
        <property type="protein sequence ID" value="ARF82557"/>
        <property type="gene ID" value="B6264_01770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34157">
        <property type="protein sequence ID" value="OEV34157"/>
        <property type="gene ID" value="HS99_0010925"/>
    </dbReference>
    <dbReference type="OMA" id="AWASGCY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041261">
        <property type="entry name" value="R2K_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18299">
        <property type="entry name" value="R2K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27727" checksum="D0B97DE99ED8B10B" modified="2017-01-18" version="1">MLTSAQATSTTGLLTAAATRRGLATAVLTGPGTVEELTGRPVHWYGGPLAAARIAAPLGLALLEPEDDWLARLPEEFTRRRIELTTLAEAWTLRHPAFVKPPADKSVPPAVYPDGSRLPRTGERIGPDTPVLVSEPVTFAAEYRLFLLDGEVLTGSRYARFGRLDPAPLTAAATAFARRLLDAVGDTLPSAVALDVGPIADPYDPAEHWAVVEANLPWFAHCYAADPDRVLDIVLRAAGPSAQLAGPDRRFVRTLRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D4</accession>
    <name>A0A1E7N0D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552271.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000642.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1879"/>
    <dbReference type="EnsemblBacteria" id="ARF77784">
        <property type="protein sequence ID" value="ARF77784"/>
        <property type="gene ID" value="B6264_01545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33933">
        <property type="protein sequence ID" value="OEV33933"/>
        <property type="gene ID" value="HS99_0010705"/>
    </dbReference>
    <dbReference type="OMA" id="RNLYWRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012646">
        <property type="entry name" value="RNA_ligase_DRB0094"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02306">
        <property type="entry name" value="RNA_lig_DRB0094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="37918" checksum="8A3AD20E123016D9" modified="2017-01-18" version="1">MSTLRVTAESLVILEHPNADALELAQVGLYRAVVAKGVYRTGDHAVYIPEQAVLPDGLIDELGLTGKLAGGAANRVKAVRLRGELSQGIVCRPAALTGTDLAGAAERGEDFAELLGIVKWQPPVPTSMSGEVVSAPDLLPWVDIENLKRHPDVFEPGEPVVLTEKLHGSCCLVTYTAATGEVKVSSKGIGAQGLALVEDERNLYWRAVRAYDLPAVAARLAERLGAERVGIFGEVFGEGVQDLTYGASALTDRPGYAAFDVSAVVDGQLSWLPAAELLEGELPLVPELWRGPFDASTVLAYAQGRETYSGRELHLREGVVVRPVVERWSPLLGGRAIAKAVSDAYLTRKGGTEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R0</accession>
    <name>A0A1E7N0R0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pntB</name>
        <name evidence="18" type="ORF">HS99_0036755</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2587"/>
    <dbReference type="EnsemblBacteria" id="OEV34278">
        <property type="protein sequence ID" value="OEV34278"/>
        <property type="gene ID" value="HS99_0036755"/>
    </dbReference>
    <dbReference type="OMA" id="AMTSMPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="9"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OEV34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="50220" checksum="B444EDB0495494F4" modified="2017-01-18" version="1">MTSTTASHAADLVAALLFILSLAGLSQHRTSRAGVVYGIAGMALALVATVVVAAQSVTAGAVALIVVAMAIGGAAGLWRARRVEMTQMPELIAVLHSFVGLAAVLVGWNSYLEVESHGSGQTRIAGDLLGIHHAEVFIGVFIGAVTFTGSVVAFLKLSARIASRPLTLPGKNALNLGALAAFLGLTVWFTAGPGPVPMVAVTLLALALGWHLVASIGGGDMPVVVSMLNSYSGWAAAASGFLLDNNLLIVTGALVGSSGAYLSYIMCKAMNRSFLSVIAGGFGIEGPSGGGGEQGEHREVHAEEVAGLLDRARSVVITPGYGMAVAQAQHPVAELTQRLRERGVEVRFGVHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFAATSVVLVIGANDTVNPAATDDPASPIAGMPVLRVWEAEQVIVFKRSMASGYAGVQNPLFFRDNTGMLFGDAGQSVEAILRALPGRDPEDALPAAGRAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Z6</accession>
    <name>A0A1E7N0Z6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553512.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3900"/>
    <dbReference type="EnsemblBacteria" id="OEV34352">
        <property type="protein sequence ID" value="OEV34352"/>
        <property type="gene ID" value="HS99_0036110"/>
    </dbReference>
    <dbReference type="OMA" id="YVRWTER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="50"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="727" mass="76680" checksum="E1B03D3B8ACDB0A3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Z7</accession>
    <name>A0A1E7N0Z7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283339.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3919"/>
    <dbReference type="EnsemblBacteria" id="OEV34368">
        <property type="protein sequence ID" value="OEV34368"/>
        <property type="gene ID" value="HS99_0036205"/>
    </dbReference>
    <dbReference type="OMA" id="GQREYGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14109" checksum="7F41750219A1A03B" modified="2017-01-18" version="1">MRIGDAAAAAGTTPRALRFYEQRGLLPPPTRTPSGQREYGPGEVARVRAIRQLLAAGLTVDDLVSRAHRFDLLDEDPPRRCCAADSGPETFAPVVSARLAALDAEITRLTSLRNKLARLAATGDTDEPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N187</accession>
    <name>A0A1E7N187_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290805.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1056"/>
    <dbReference type="EnsemblBacteria" id="ARF78944">
        <property type="protein sequence ID" value="ARF78944"/>
        <property type="gene ID" value="B6264_08455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34457">
        <property type="protein sequence ID" value="OEV34457"/>
        <property type="gene ID" value="HS99_0035740"/>
    </dbReference>
    <dbReference type="OMA" id="VKGGWEK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="26247" checksum="75FCF69C38B38ED8" modified="2017-01-18" version="1">MLLVGSGRHRRRTQAEKAIAVAGVAGVGLALPLLTATGASAAPASAWDSVAQCESGGDWSINTGNGFYGGLQFTSSTWKAYGGTAYAAQANQASRAQQISVAEKVLASQGPGAWPVCSVKAGLSKGGAPAAVDTSSDTRAQKQQAAPKQQAPKQQAQKAAPKPVQQYAPKHAAPKKAEQPVEQPAQQYTPKHAAPRAAQPAPTPQTGHDYTVRSGDTLSGIAAAQGVSGGWQALYDGNRGTVGGDPNLIVPGQVLHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B3</accession>
    <name>A0A1E7N1B3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286571.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene361"/>
    <dbReference type="EnsemblBacteria" id="ARF78935">
        <property type="protein sequence ID" value="ARF78935"/>
        <property type="gene ID" value="B6264_08405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34466">
        <property type="protein sequence ID" value="OEV34466"/>
        <property type="gene ID" value="HS99_0035790"/>
    </dbReference>
    <dbReference type="OMA" id="REPRIMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="12002" checksum="7982C3E5A7C868C6" modified="2017-01-18" version="1">MHDVQPLVEAVDKLADRFRSLPQSKLLGAVPGHPSRAAAALALARRLAALALAAEGGPEREFPDAGAFAAGDQLAVAGHDLAAALAALPEGAAVALPDGPAAAAEVLAGAVAAVRETAELCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J2</accession>
    <name>A0A1E7N1J2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552813.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5576"/>
    <dbReference type="EnsemblBacteria" id="ARF79343">
        <property type="protein sequence ID" value="ARF79343"/>
        <property type="gene ID" value="B6264_10795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34552">
        <property type="protein sequence ID" value="OEV34552"/>
        <property type="gene ID" value="HS99_0035265"/>
    </dbReference>
    <dbReference type="OMA" id="RRQFNVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="17307" checksum="49BAFBEA680977D0" modified="2017-01-18" version="1">MARTEFYDDPNAPKPNRLVVAASAVVTDEEGRILLQRRTDNGLYALPGGTMDLGESLPGTAVREVREETGLDVEITGLVGTYTDPRHVIAYSDGEVRQQFNVCFTARITGGELRISNESTDLQFVAPSDIGELPMHHTQQLRLRHFLEHRATPYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1P4</accession>
    <name>A0A1E7N1P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558152.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82032">
        <property type="protein sequence ID" value="ARF82032"/>
        <property type="gene ID" value="B6264_26925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34602">
        <property type="protein sequence ID" value="OEV34602"/>
        <property type="gene ID" value="HS99_0008865"/>
    </dbReference>
    <dbReference type="OMA" id="HECPSAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27532" checksum="BA557AB373D1D52D" modified="2017-01-18" version="1">MPSPGRRKALPAVGAVVALAALSAVVRYADREPRADAGLFSQVLLSADGRTLTTPVMWAPCQEAEPRLFARETPQTVAADLKTGRTVDQTHECPSAGRLVSLTLHASLGTRQLSEANTGKPFVPFPAARLADVGYLPPGFTAISDVPQVFGSVAGPWTPNPYNRSDTVPSWTRYYATVGKPALSITQNLPAAGTHDPAPGTHAGPPMSVNGHSASLVCDTDSERALTWSDGVSTFTVVSIDPHHAALSPSELLRVANGLRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N291</accession>
    <name>A0A1E7N291_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385563.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3228"/>
    <dbReference type="EnsemblBacteria" id="ARF81837">
        <property type="protein sequence ID" value="ARF81837"/>
        <property type="gene ID" value="B6264_25710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34802">
        <property type="protein sequence ID" value="OEV34802"/>
        <property type="gene ID" value="HS99_0010030"/>
    </dbReference>
    <dbReference type="OMA" id="RAHFARD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22661" checksum="09F4B128ABD43C63" modified="2017-01-18" version="1">MPLPRFDRLPAERREHILGVARRHFAEHGAEGASYNKIIEAAEVSKTAAYHYFDGREDLLTAVLDGVLDRLLDALGPWDPARDEEDFGARFTAGCAALAAHLRDHPEDLALADAAIGRSDGSLWLDWFGALVTDGRRLGMIRTDVDHALMVSVTAAVVRAADAWAVALMTSGSLEGLPEGAPPDQLWRLLRGLWGAAATPAPGQEPNDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2C5</accession>
    <name>A0A1E7N2C5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557730.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7599"/>
    <dbReference type="EnsemblBacteria" id="ARF81780">
        <property type="protein sequence ID" value="ARF81780"/>
        <property type="gene ID" value="B6264_25360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34858">
        <property type="protein sequence ID" value="OEV34858"/>
        <property type="gene ID" value="HS99_0010360"/>
    </dbReference>
    <dbReference type="OMA" id="STYLVCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24533" checksum="D27492CA7639CBF4" modified="2017-01-18" version="1">MRVVFVHGACVRDGSWWWHRTAELLRERGMRSVAPALPSCGEAGLPGGRGGPGLAEDVAAVRQVLLDGDEPTVVVAHSYGGIITAEAAAGVGAVRHLVLISSYLPEVGQSLSDFGDGSPAPFLDVDSDAGTFGVRSGLLVDTFLQDCDPEIQAQAADHLARQSVQVTGQPVRAAAWHQVPSTYLVCAQDRGTPPRLQREFARRASSVVELDAGHHPFLSQPDTVRDLLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H0</accession>
    <name>A0A1E7N2H0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387352.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000838.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7590"/>
    <dbReference type="EnsemblBacteria" id="ARF81773">
        <property type="protein sequence ID" value="ARF81773"/>
        <property type="gene ID" value="B6264_25315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34865">
        <property type="protein sequence ID" value="OEV34865"/>
        <property type="gene ID" value="HS99_0010405"/>
    </dbReference>
    <dbReference type="OMA" id="PGYNEFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="727" mass="77289" checksum="9A986536E2D3D97B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L4</accession>
    <name>A0A1E7N2L4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288648.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5900"/>
    <dbReference type="EnsemblBacteria" id="ARF82064">
        <property type="protein sequence ID" value="ARF82064"/>
        <property type="gene ID" value="B6264_27130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34939">
        <property type="protein sequence ID" value="OEV34939"/>
        <property type="gene ID" value="HS99_0035115"/>
    </dbReference>
    <dbReference type="OMA" id="MAFPRPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30699" checksum="AC7C2F6AAE9760C2" modified="2017-01-18" version="1">MTTNHDTSWAAETEPAAPAPITPADVADAARLVSFGLQAKLLPARDAEYAELVRRHREDPPFARLADAIATGMGLVVLEVSPRAGMAVAAAEDSLFAVRMGDYSRRAASESTDRFLHGLAHLAVAALAFPRPEDLADDGYLGRITVNGVDSFVRQACRRLEEQADADGANTDPASDAPGLEAAWRVWARRTATGATKDARRLSGSTIGIVAKAVMFLVDSGFLQKVSDDSGGTYRTTARYQLQVRDLAGSAAMAELLDLGIVPVSDGTASLLPPDTGDELVADAGLPFHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F0</accession>
    <name>A0A1E7N3F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366650.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1396"/>
    <dbReference type="EnsemblBacteria" id="ARF79253">
        <property type="protein sequence ID" value="ARF79253"/>
        <property type="gene ID" value="B6264_10290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35194">
        <property type="protein sequence ID" value="OEV35194"/>
        <property type="gene ID" value="HS99_0033260"/>
    </dbReference>
    <dbReference type="OMA" id="WFHRRST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="502" mass="53342" checksum="6559A6FE68CAD6C6" modified="2017-01-18" version="1">MTTALDEIHLPAAARTVRRLRLRPDGALAPLGPRAVRLTAPVGALSLPDLAPGAMEAVAALAAGEQTEEELAALVAARDGDAGLLRWQLTRRRLGTAGMLEHSVHLAGEAAEEPLARLRPVGRGAAEPGPTPDPTGQVKLSRFASASVEGGALLVRAPGSPLAVQLTTRAAGLLAALAGWTSPAALAQLPGGLPLDAVRQTLRLFAAAGLLAYGSPGAEPEAEEQRFAQWTAADLAFHSRTRRPTSVAGYGGTYRFGDRFAPEPASPAPFAGRKVALPVPDLDELVRTDRPFTEVLEQRRSVRDHDERAPITLEQLGELLHRSARRRQTFTGGDGQELADRPYPSGGAVHELELYPLVTSCTGLEPGLWHYATDRHELELVSEPSAATAQLVKSARESSLMQTDPQVVLLVTARFGRVMWKYETVAYPLILKHVGALYQTLYLVGTAMDLAVCGLGGGDAADFAAASGLDYFTEGSVGELVIGSRPPTLRQDVGVPRREARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3N9</accession>
    <name>A0A1E7N3N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine-specific anthranilate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282829.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5317"/>
    <dbReference type="EnsemblBacteria" id="ARF80725">
        <property type="protein sequence ID" value="ARF80725"/>
        <property type="gene ID" value="B6264_19060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35300">
        <property type="protein sequence ID" value="OEV35300"/>
        <property type="gene ID" value="HS99_0033120"/>
    </dbReference>
    <dbReference type="OMA" id="RKEVPYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="652" mass="69749" checksum="B10850162D384BA9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N454</accession>
    <name>A0A1E7N454_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">HS99_0032305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737913.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35444">
        <property type="protein sequence ID" value="OEV35444"/>
        <property type="gene ID" value="HS99_0032305"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="301"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="60525" checksum="F9800E9A8C445734" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N456</accession>
    <name>A0A1E7N456_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387236.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5545"/>
    <dbReference type="EnsemblBacteria" id="ARF79369">
        <property type="protein sequence ID" value="ARF79369"/>
        <property type="gene ID" value="B6264_10940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35481">
        <property type="protein sequence ID" value="OEV35481"/>
        <property type="gene ID" value="HS99_0031745"/>
    </dbReference>
    <dbReference type="OMA" id="QGAQVYH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="28327" checksum="EB6AA13D32C45963" modified="2017-01-18" version="1">MTSTAHPIGGDLPYRLVATDLDGTLLTSAETVSERTRAALAAATGAGALHIIVTGRSAVWARPVFDEIGYTGIAVCGQGAQVYDAGAHRLLTSLTLDRRLAALAIEKIEAETGPLAVASNQDGLDGQVLAGPGYELLIGSDLPVVRVGRGELLASPVAKLYIQHPGLTDDSLAEAARRAAGDLVGVVMAGAGVVELLPLGLSKATGLAVAARRLGVRSADTIAFGDMPNDVPMFGWAAHGVAMAGAHEELLAVADEVTAGNDEDGVALVLERLFPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N460</accession>
    <name>A0A1E7N460_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278144.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5551"/>
    <dbReference type="EnsemblBacteria" id="ARF79365">
        <property type="protein sequence ID" value="ARF79365"/>
        <property type="gene ID" value="B6264_10910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35479">
        <property type="protein sequence ID" value="OEV35479"/>
        <property type="gene ID" value="HS99_0031715"/>
    </dbReference>
    <dbReference type="OMA" id="CPLTMNN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="23814" checksum="53B84075D1EC3C46" modified="2017-01-18" version="1">MPRTTRTARTTRLAGAAALALAAALTLSACGSSGGGSTAAKVTQQKDDSPYQGTKLAKNFEKPDLQLTDTSGQPYDLRQQTNGKATLLFFGYTSCPDVCPTTMGDIGVAMKALSPEDRKKINVVFVSTDPQRDTPKVLRTWLDSMGTDFIGLTGDLSKVKTAARSLGIMIEDPVVNADGTVTSTHGAQVLAFLPSDDKAHVLYMSGTEEKTYEHDLPLLAKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N496</accession>
    <name>A0A1E7N496_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552748.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000271.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5507"/>
    <dbReference type="EnsemblBacteria" id="ARF79399">
        <property type="protein sequence ID" value="ARF79399"/>
        <property type="gene ID" value="B6264_11125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35510">
        <property type="protein sequence ID" value="OEV35510"/>
        <property type="gene ID" value="HS99_0031935"/>
    </dbReference>
    <dbReference type="OMA" id="AIDWHFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="21214" checksum="799DA9F775A9E219" modified="2017-01-18" version="1">MEKNTYKLVVLVGSVREGRFGPVVSSWVAEQALAHGGFEVEVVDLAEFELPLALPAAPPKFAGADYPRPAGMAGLTRALDGADAVLIVTPEYNHSYPASLKAAIDWHFTQWTAKPVAFVSYGGAAGGRHAVLHLENVLTELHAVTIRDGLSFPNYFTAWTDGRPDDPQAAGYAKAMLDQLVWWAGALKNARAAAPYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J1</accession>
    <name>A0A1E7N4J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gltD</name>
        <name evidence="5" type="ORF">HS99_0006765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene972"/>
    <dbReference type="EnsemblBacteria" id="ARF80807">
        <property type="protein sequence ID" value="ARF80807"/>
        <property type="gene ID" value="B6264_19535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35611">
        <property type="protein sequence ID" value="OEV35611"/>
        <property type="gene ID" value="HS99_0006765"/>
    </dbReference>
    <dbReference type="OMA" id="DCVGTAH"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="52687" checksum="10D3DC727D26B7FF" modified="2017-01-18" version="1">MADPKGFLTTPKQLAERRPVDVRIRDWNEVYVERSLLPIISKQAGRCMDCGIPFCHNGCPLGNLIPEWNDLAYRDDFTGAIERLHATNNFPEFTGRLCPAPCESACVLGINQDAVTIKNVEVTIIDKAWDRGGVTPQIPERLSGKTVAVVGSGPAGLAAAQQLTRAGHTVVVYERADRIGGLLRYGIPEFKMEKRHINRRIEQMRAEGTRFRTGVHVGEDITGQQLRERFDAVVVAAGATTARDLPVPGRELKGVHQAMEYLPLANKVQEGDLVDSPISAKGKHVVVIGGGDTGADCVGTAHRQGALSVTQLEIMPRPGEERPGHQPWPTMPMTYKVTSAHEEGGERVYSVNTTHLTGDEDGNVQELHLVEVEFKDGRFEPVPGTERTIPAQLVTLAMGFTGTDVRNGLVEQLGVDLDARGNIARDGRFATNVDGVYVCGDAGRGQSLIVWAIAEGRSAAAAVDRYLGGKTPLPAPIRPTDRPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R8</accession>
    <name>A0A1E7N4R8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0007245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene877"/>
    <dbReference type="EnsemblBacteria" id="OEV35691">
        <property type="protein sequence ID" value="OEV35691"/>
        <property type="gene ID" value="HS99_0007245"/>
    </dbReference>
    <dbReference type="OMA" id="AHRGPYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="536" mass="56426" checksum="E33C1D11E93DD4C4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T2</accession>
    <name>A0A1E7N4T2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfatase-modifying factor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene914"/>
    <dbReference type="EnsemblBacteria" id="ARF80857">
        <property type="protein sequence ID" value="ARF80857"/>
        <property type="gene ID" value="B6264_19830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35664">
        <property type="protein sequence ID" value="OEV35664"/>
        <property type="gene ID" value="HS99_0007060"/>
    </dbReference>
    <dbReference type="OMA" id="EWQYACK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="24102" checksum="DE1A6674DEB8DB74" modified="2017-01-18" version="1">MEPSTGLIAVPPGRVMLSDRRTQRTWGVEVAPFELAVCPVTREQYEGVAGDRRPAHSVSWLDAVRYCNELSRREGLAPAYRVDGEDVSWDRSADGYRLPTEAEWEHACRAGTDGPRYGPLDEIAWYRGNSGERPHSVGELRPNAYGLYDLLGNVWEWCWELYDPEVYGSYRVLRGGGWFDEHWSCRASVRRRSHPTLRIDDVGFRLARSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T9</accession>
    <name>A0A1E7N4T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551109.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene860"/>
    <dbReference type="EnsemblBacteria" id="ARF80907">
        <property type="protein sequence ID" value="ARF80907"/>
        <property type="gene ID" value="B6264_20105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35706">
        <property type="protein sequence ID" value="OEV35706"/>
        <property type="gene ID" value="HS99_0007335"/>
    </dbReference>
    <dbReference type="OMA" id="AAAWFNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="38460" checksum="FFA2BA05B7A3A7E5" modified="2017-01-18" version="1">MKLSDIPLGWAVTGVVGLLVSALLLALARSRGSAAGGDSWERSEERRRNKESLYGAASYTLLFCCAGVAAALSFHGLVGFGVQNLGLSGGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRLLVWLFAGASAWFNWVHAPRGFGHAGAPQFFSGMSLSAAVLFDRALKQTRRAALREQGLVPRPLPQIRIVRWLRAPRETYAAWSLMLLEGVRSLDEAVDEVRDEKRERALEKERRKLAGRRERAEIRAINRGSSHWRGRGGAARQLEPAGSEPAIAGGPGAELPAGAREVGAPAAAEPGAREVEAAEGTVVQPGLPARPERRTIDLTVDEDTVTLPRLDSLERKLKDLEQQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B1</accession>
    <name>A0A1E7N5B1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0008445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286191.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000764.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7257"/>
    <dbReference type="EnsemblBacteria" id="ARF81091">
        <property type="protein sequence ID" value="ARF81091"/>
        <property type="gene ID" value="B6264_21220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35880">
        <property type="protein sequence ID" value="OEV35880"/>
        <property type="gene ID" value="HS99_0008445"/>
    </dbReference>
    <dbReference type="OMA" id="LGMPAFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34935" checksum="1EE9B64E8182E9A6" modified="2017-01-18" version="1">MILYLGRRLLGALGILLAICAITFTIFYLLPADPAVAACGKTCSPERVAEVKAAMGLDQPVWEQFATYVTGIFAGRDYGSGAGATHCGFPCLGYSYEYSLPVWGLLTDRLPVSVSLAVGASVLWLVLGLGAGVTSALRKGGAVDRTLMVFSVGAASLPVYFTSIMLIWGVVRTAGLLPYPSYHAFTDGPVAWASNLLLPWIALALLYAAMYARQSRNSMIEAMAEPYIRTARAKGLPPRTVTVKHGLRSGMTPILTIFGMDLGGLLAGAVITESIFGLPGVGRLFYDALVRSDQPVILGVTLLAATFIVAANLLVDVLYAYVDPRVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D5</accession>
    <name>A0A1E7N5D5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="15" type="ORF">HS99_0008570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286236.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7282"/>
    <dbReference type="EnsemblBacteria" id="ARF81113">
        <property type="protein sequence ID" value="ARF81113"/>
        <property type="gene ID" value="B6264_21345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35902">
        <property type="protein sequence ID" value="OEV35902"/>
        <property type="gene ID" value="HS99_0008570"/>
    </dbReference>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV35902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="833" mass="88009" checksum="4EB26F94C71E4E7C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U7</accession>
    <name>A0A1E7N5U7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280945.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4952"/>
    <dbReference type="EnsemblBacteria" id="ARF80020">
        <property type="protein sequence ID" value="ARF80020"/>
        <property type="gene ID" value="B6264_14860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36076">
        <property type="protein sequence ID" value="OEV36076"/>
        <property type="gene ID" value="HS99_0030880"/>
    </dbReference>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="29099" checksum="5083CFD27BE414AB" modified="2017-01-18" version="1">MSTPTVEHSAALDAAEAGGIQLITVTFRIRRFNPEEHPDPVWVDYQLTLDPKERVLDALNKIKWEQDGTLTYRRSCAHGICGSDAMRINGRNRLACKTLIKDVNPEKPITIEAIKGLTVLKDLVVDMDPFFQAYKDVMPFLITKGNEPTRERLQSAEDRERFDDTTKCILCAACTSSCPVFWNDGQYFGPAAIVNAHRFIFDSRDEGAEQRLEILNDREGVWRCRTTFNCSEACPRGIEVTKAIQEVKRALVTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V6</accession>
    <name>A0A1E7N5V6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">HS99_0031650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6344"/>
    <dbReference type="EnsemblBacteria" id="OEV36071">
        <property type="protein sequence ID" value="OEV36071"/>
        <property type="gene ID" value="HS99_0031650"/>
    </dbReference>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21805" checksum="AD888577A7675FFA" modified="2017-01-18" version="1">MEGAASEAPVKVIGEEPDLSKGTARPITVVGNPVLHREVKDVTAFDGELSALIDDMFQSMYAAEGVGLAANQIGVDLKVFVYDCPDDEGVRHIGHVINPKLEEYPADRRRVLDDGNEGCLSVPTAYAELPRPDYAAVTGVDKDGKPIRVEGTGFFARCLQHETDHLYGTLYIDKLSKRDRKDALKQMAEGTAKYATVPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X3</accession>
    <name>A0A1E7N5X3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase hydrophobic membrane anchor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0030890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Membrane-anchoring subunit of succinate dehydrogenase (SDH).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280950.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4954"/>
    <dbReference type="EnsemblBacteria" id="ARF80022">
        <property type="protein sequence ID" value="ARF80022"/>
        <property type="gene ID" value="B6264_14870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36078">
        <property type="protein sequence ID" value="OEV36078"/>
        <property type="gene ID" value="HS99_0030890"/>
    </dbReference>
    <dbReference type="OMA" id="WLFMRLS"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014312">
        <property type="entry name" value="Succ_DH_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02968">
        <property type="entry name" value="succ_dehyd_anc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV36078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="18009" checksum="8D0D727D34419EBA" modified="2017-01-18" version="1">MSTEISDALVVPSKHAHTGKGLGTGNPADAFVIEPPRKRTAKTPRRTRTNFEMLAWLFMRLSGVVLVVLILGHLLIMLVLDGGVSKIGFAFVAGRWASPFWQGWDLLMLWLAMLHGANGMRQVINDYAEKDSTRLWLKGLMGTATVFTVLLGTLVIFTFDPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N614</accession>
    <name>A0A1E7N614_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0031270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366747.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5030"/>
    <dbReference type="EnsemblBacteria" id="ARF80091">
        <property type="protein sequence ID" value="ARF80091"/>
        <property type="gene ID" value="B6264_15250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36146">
        <property type="protein sequence ID" value="OEV36146"/>
        <property type="gene ID" value="HS99_0031270"/>
    </dbReference>
    <dbReference type="OMA" id="FWSYRTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20766" checksum="5F7AFD91E2705E20" modified="2017-01-18" version="1">MATTAASKPPLVQKLRGLTGEVVKFGIVGLSGVVINFAVFWVCINGLGLASLRSNIAATVIAIATNYLGYRYWLYRDRDAASRKREITLFLVFSGIGMLIETGVLAFTVYVLHLDSHYEQLGAKVIGLAVATVFRFVSYRTWVFTALPEPEPAAVASTADAAHAAHTADGQELAAQAELMLVTEQIRYAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N644</accession>
    <name>A0A1E7N644_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4999"/>
    <dbReference type="EnsemblBacteria" id="OEV36155">
        <property type="protein sequence ID" value="OEV36155"/>
        <property type="gene ID" value="HS99_0031110"/>
    </dbReference>
    <dbReference type="OMA" id="LQPMWQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="176"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="373" mass="39965" checksum="D25CDC34310A3C73" modified="2017-01-18" version="1">MAEDGSSGTAGNHDPTVALELERLILDAPRRYTPYQAARAADVPMELATRFWRAMGFPDIGQSRALTDGDVIALRRLAGLVESGLLSESMAIQVARSTGQTTARLAGWQMDTFLENLTQSAEPGLTRADVAYPLVELLLPELEQFLVYVWRRQLAAVTGRVVQAAEDNEITSGRLAVGFADLVGFTRLSRRLEEEELGELVETFENTCSDLIAGQGGRVIKTLGDEILYVTEDPSTAAEIALSLIEALAEDDTIPALRVGMAFGTVTQRMGDVFGTTVNLASRLTSIAPKDAVLIDGEFAAALEQHGSVGPAESEGPGLAEALSVAAGMPASGLPVPAPDTGARFHLQPMWRRPVRGLGLVEPWLLSRRTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H7</accession>
    <name>A0A1E7N6H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550854.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2627"/>
    <dbReference type="EnsemblBacteria" id="OEV36292">
        <property type="protein sequence ID" value="OEV36292"/>
        <property type="gene ID" value="HS99_0030255"/>
    </dbReference>
    <dbReference type="OMA" id="ENTHNVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="36786" checksum="518C6A0404FAF303" modified="2017-01-18" version="1">MIEMRSDTFTLPTPEMLTAMTEAELGDDVYGEDPTVNELERRSAELTGKEAACFFPSGTMANLASVMAHAPRGTKAVVGTESDIWLYEAGGASVCGGVVYEPVPNRPDGTIALADLAASFPADPDDPQFALPSLICLENTHNRCGGAVLPLDYLAEVRRFADERGVAVHLDGARVVNAAIAAGVEVAEITAHVDSVQFCLSKGLGAPVGSMVAGSAEFVGKVRRLRKMLGGGMRQVGLLAAAALVALDTRERLAEDHANARRLAEGLALIPGVEMDPDTVKTNIVIFKVTDERFTWRTFLASVHQQGLAVTEFGHGRIRAVVHNGVSAEDVTAAVGIVARVLKEGPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6S5</accession>
    <name>A0A1E7N6S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurium resistance protein terZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284454.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000715.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4904"/>
    <dbReference type="EnsemblBacteria" id="ARF82367">
        <property type="protein sequence ID" value="ARF82367"/>
        <property type="gene ID" value="B6264_28950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36344">
        <property type="protein sequence ID" value="OEV36344"/>
        <property type="gene ID" value="HS99_0029710"/>
    </dbReference>
    <dbReference type="OMA" id="GGWEMAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="20860" checksum="1401FA3D735EB003" modified="2017-01-18" version="1">MTVSLAKGQKISLEKPGGGQLSLVRMGLGWKAVQRKGFLAKLLSAGREIDLDASAVLFSGGRSVDVVYFQHLTSNDGSVRHSGDNLVGGAGDATDDESITVDLTRVGAEVDQILFTVNSFTGQTFQEVEAAFCRLVDETTGIELARYTLTDGGPYTAQIMAKVQRTPAGWQMVAIGRPAGGRTFKDLMPELLKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N765</accession>
    <name>A0A1E7N765_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferric nitrobindin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks the conserved His residue that binds heme iron in the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1460"/>
    <dbReference type="EnsemblBacteria" id="ARF79179">
        <property type="protein sequence ID" value="ARF79179"/>
        <property type="gene ID" value="B6264_09830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36518">
        <property type="protein sequence ID" value="OEV36518"/>
        <property type="gene ID" value="HS99_0028750"/>
    </dbReference>
    <dbReference type="OMA" id="EKCNFGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="2">
        <location>
            <begin position="12"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21615" checksum="FAE859AFC3BEAFCF" modified="2017-01-18" version="1">MIEIPSDLHKDVVPLAFLLGTWEGAGVYDFPGTEKCNFGQEIVIRHDGRPFLEFRSRTWVLNEEGEKVRPLENEHAFWRITSNHDGTTGARGIEISSVRDDGTVEIWYGELADGKPQVDVSTDAVARIEGSPEYSGGKRLYGFVNGELLWVGEKAAPNVPLRPYMSAQLKKVLSPAQLIKDINDLPDDGIAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N818</accession>
    <name>A0A1E7N818_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480742.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4778"/>
    <dbReference type="EnsemblBacteria" id="OEV36831">
        <property type="protein sequence ID" value="OEV36831"/>
        <property type="gene ID" value="HS99_0027450"/>
    </dbReference>
    <dbReference type="OMA" id="RKTPKRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="319"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="525" mass="55683" checksum="4FB505DC0649960E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N871</accession>
    <name>A0A1E7N871_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551378.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6483"/>
    <dbReference type="EnsemblBacteria" id="ARF78655">
        <property type="protein sequence ID" value="ARF78655"/>
        <property type="gene ID" value="B6264_06780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36896">
        <property type="protein sequence ID" value="OEV36896"/>
        <property type="gene ID" value="HS99_0026905"/>
    </dbReference>
    <dbReference type="OMA" id="DIGDLHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="47857" checksum="5D49BEF0D59A51F8" modified="2017-01-18" version="1">MTGPAEQAESTAVPAQRSGRHAAPRTPVRVRLRGRALAMAAVPTALLMAAAYTPNPAVAESAAGKPCGNAPVTVPDVAPIETPVPKSELPEPPPAPSGTAGTSGAASTGAPSAGPGSVPTTTPTQAPTKAPTTAPVKPSATGTATTPPAVRSAATGGSGAVSAVYQGTADGTATASRAGLIDDLVGGINHLLNPGGSASPTPTATPSATPQAPAAPAPRVGTPAQPSQSQPQAPSTGAQSSAGQSSGTQSSGAQPSAGQPSPGATPSGGKSSTKAAPSATPSSDVPATPAATATPSASPTANPNCDVDARNLTAGKATAEQVVPEQNWTLRSSRLGLHGAAFHGVYDVKTPTGTKRVLKFVVDSVDIENLDMSTLEGNGVTFHVQGAPGSTSTMRNGQVTMYVERLSGHLSKVLGLPIPIDLGEITLTPDTLPRWLYDLIGSVPIPLDLELTGVTAKQAGQFGGTLHIPGMHLFNDNAPYSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N894</accession>
    <name>A0A1E7N894_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mini-circle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366975.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2475"/>
    <dbReference type="EnsemblBacteria" id="OEV36693">
        <property type="protein sequence ID" value="OEV36693"/>
        <property type="gene ID" value="HS99_0028450"/>
    </dbReference>
    <dbReference type="OMA" id="AYATWQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="19148" checksum="5ACC02BB64165BF2" modified="2017-01-18" version="1">MTELTPRVDPPMAADEAAMLTSWLDYHRSTLALKCEGLTDDQLRLRSVPPSTLSLLGLVRHMAEVERHWFQGVLLGEEFATGHYWTEADPDGDFDHVDTADVAADFATWRAEIEAASRAVAGQPLDTVGKRARQDQEVTLRWILVHMIEEYARHNGHADLLRELVDGSTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X6</accession>
    <name>A0A1E7N8X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555691.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6642"/>
    <dbReference type="EnsemblBacteria" id="ARF81594">
        <property type="protein sequence ID" value="ARF81594"/>
        <property type="gene ID" value="B6264_24205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37139">
        <property type="protein sequence ID" value="OEV37139"/>
        <property type="gene ID" value="HS99_0004790"/>
    </dbReference>
    <dbReference type="OMA" id="NWITSEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046176">
        <property type="entry name" value="DUF6185"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19683">
        <property type="entry name" value="DUF6185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="891" mass="97988" checksum="3A8A472A8BF0DC95" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z6</accession>
    <name>A0A1E7N8Z6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6225"/>
    <dbReference type="EnsemblBacteria" id="OEV37159">
        <property type="protein sequence ID" value="OEV37159"/>
        <property type="gene ID" value="HS99_0004895"/>
    </dbReference>
    <dbReference type="OMA" id="TRIHERH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="40361" checksum="48755ED71741E76C" modified="2017-01-18" version="1">MGVGVRRADDERLGRRNRMLVLIPVALIVLITVVDIHSSKDIHLGPLLVIAPALTPSFAGPRATAAIGALAVAAQVFIAVLHGGLTTSNHLAQIAALTVLSALIVVFTLVREHRNRQLVRAQSVSEAAQRALLRPLPDRIGPLELATTYLAAEDETHIGGDLYTATRTDDGTRVLIGDVRGKGLAAVGEAALLLSAFRLVAARHRDLADLARTLHRHVERYLVDFADSGDETGEHFITALLLDIPDDEPVVSLTNCGHPPPLLLRQGRVRVLEDTEAAPPLGVPVAAPDAHRSRTTPFRSDDTLLLYTDGVTEARDRDGVFYPLAERTARWATCAPEALVAHLRRDLLSHCGGRLGDDAAIIAIRRTPTAGHPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B8</accession>
    <name>A0A1E7N9B8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555246.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1340"/>
    <dbReference type="EnsemblBacteria" id="OEV37234">
        <property type="protein sequence ID" value="OEV37234"/>
        <property type="gene ID" value="HS99_0005375"/>
    </dbReference>
    <dbReference type="OMA" id="FVLWREV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15189" checksum="A9743417FD0D4672" modified="2017-01-18" version="1">MSTKHRSAGSPPPFVLWREVLVAYAMPAVMAAAGGVASGQPHLVIAALTTIAGTSAVVAGALGARLRRRPDGSWAARAPRLPLAAGAGLGAAVLAALLGWAGARWLPDVPALAGSPWPARLRLDLPISATIAATMITWRWRGTRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9I5</accession>
    <name>A0A1E7N9I5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556438.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82474">
        <property type="protein sequence ID" value="ARF82474"/>
        <property type="gene ID" value="B6264_29610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37360">
        <property type="protein sequence ID" value="OEV37360"/>
        <property type="gene ID" value="HS99_0006135"/>
    </dbReference>
    <dbReference type="OMA" id="YRQHRAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="14917" checksum="79B867030CE765B3" modified="2017-01-18" version="1">MHGELQELGRAVKQAQYRQHRALDSALSAIGTTLAQWDALRAISRSPGASARELAEATFQTGQAFGTLVGRLAAQGLVERRPGHGRRIEHHLTPAGEQVLTVGHKVADEVLAACFSSLSDADRATLLDLLQRLTAGRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y1</accession>
    <name>A0A1E7N9Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0026145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287155.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7972"/>
    <dbReference type="EnsemblBacteria" id="ARF79072">
        <property type="protein sequence ID" value="ARF79072"/>
        <property type="gene ID" value="B6264_09210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37501">
        <property type="protein sequence ID" value="OEV37501"/>
        <property type="gene ID" value="HS99_0026145"/>
    </dbReference>
    <dbReference type="OMA" id="DAQLMYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24979" checksum="46CC4A9DD8A11F82" modified="2017-01-18" version="1">MSGLIDTTEMYLRTILELEEEGIVPMRARIAERLEQSGPTVSQTVGRMERDGLLQVAGDRHLELTEEGRRLAVRVMRKHRIAECLLVDVIGLEWEQVHEEACRWEHVMSETVERKVLAMLGHPTQSPYGNPIPGLDELGDTKAEGEGFDAALVPLDSVKPGETGADVVVRRIGEPIQTDSALMSTLRRAGIRPGSTVKVTTGVGGVLVGSGENAAELGKDIAQHVFVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA01</accession>
    <name>A0A1E7NA01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287174.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000738.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7984"/>
    <dbReference type="EnsemblBacteria" id="ARF79061">
        <property type="protein sequence ID" value="ARF79061"/>
        <property type="gene ID" value="B6264_09150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37512">
        <property type="protein sequence ID" value="OEV37512"/>
        <property type="gene ID" value="HS99_0026205"/>
    </dbReference>
    <dbReference type="OMA" id="GYKEVGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="19461" checksum="CA24DAACCE9F7058" modified="2017-01-18" version="1">MALTFTLDPKLDPDLRTAVVRLWTDVTNAGGAVGFVAPVTEDEVWDTADHQFAGVHPDGPDRLLVAHESATGRLVGVLFFASMRFAPMEHWRMLKRVMVHPDFQGLGYGAELLAEAERVARAWGLESLRLTARGGLGLERFYTRCGYREVGRVPAAIRVAPGDDRDDITMWLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA25</accession>
    <name>A0A1E7NA25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552365.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1147"/>
    <dbReference type="EnsemblBacteria" id="ARF79026">
        <property type="protein sequence ID" value="ARF79026"/>
        <property type="gene ID" value="B6264_08930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37545">
        <property type="protein sequence ID" value="OEV37545"/>
        <property type="gene ID" value="HS99_0026425"/>
    </dbReference>
    <dbReference type="OMA" id="IGRIANW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16111" checksum="9BB74130F5E6BA57" modified="2017-01-18" version="1">MDGFEQRMDSAWEWWGAAIEGSQEGRWIRTDDERRIIDDIAAAAVGCPPSPDELPWRARLARIVRWAAVLRLAAGAGGWELAPVAGAAPPRPAGMAALLSAVYAVGEQGEIWLRGLPADGPPPVAEVLKAEAFLFGPGSVEDLRQFFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA38</accession>
    <name>A0A1E7NA38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286508.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79022">
        <property type="protein sequence ID" value="ARF79022"/>
        <property type="gene ID" value="B6264_08910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37549">
        <property type="protein sequence ID" value="OEV37549"/>
        <property type="gene ID" value="HS99_0026445"/>
    </dbReference>
    <dbReference type="OMA" id="GRHCADA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046053">
        <property type="entry name" value="DUF6011"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19474">
        <property type="entry name" value="DUF6011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="7447" checksum="3D1BE49A0EF7D4E9" modified="2017-01-18" version="1">MTSPEPEPLPGTDTTRALRPRVTCRRCHRPLHDPESRMLRLGPECRDPAERVARFEVEQETLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA45</accession>
    <name>A0A1E7NA45_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5426"/>
    <dbReference type="EnsemblBacteria" id="OEV37363">
        <property type="protein sequence ID" value="OEV37363"/>
        <property type="gene ID" value="HS99_0006150"/>
    </dbReference>
    <dbReference type="OMA" id="TRAYVAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="276"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="361"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="530" mass="51944" checksum="D1AB83F5EDAE3D5E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD5</accession>
    <name>A0A1E7NAD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280698.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1714"/>
    <dbReference type="EnsemblBacteria" id="ARF79899">
        <property type="protein sequence ID" value="ARF79899"/>
        <property type="gene ID" value="B6264_14185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37642">
        <property type="protein sequence ID" value="OEV37642"/>
        <property type="gene ID" value="HS99_0025400"/>
    </dbReference>
    <dbReference type="OMA" id="PLEICNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25584" checksum="45CC960C3836B423" modified="2017-01-18" version="1">MANTPPGGPGPATGHGLDDRVPFLARLDHADRTALLALGRRLDYPARTAALREGEPSDHVLLVLRGWLKVTAAAENGYEALLALRGPGDIVGESAALSGRPRAATVTALEQVETTAVDRAAFTAYLQRTPAASMQLLALSTDRLRAADHHRLKFASLTVSERLADLLLELARTHGRRTAEGIVVSVPLSQQELAGSVGASREAVARLLKSLRDRGIVVTSRRSLVIARPDLLRRPGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR6</accession>
    <name>A0A1E7NAR6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558070.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000545.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7560"/>
    <dbReference type="EnsemblBacteria" id="ARF78084">
        <property type="protein sequence ID" value="ARF78084"/>
        <property type="gene ID" value="B6264_03365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37781">
        <property type="protein sequence ID" value="OEV37781"/>
        <property type="gene ID" value="HS99_0024635"/>
    </dbReference>
    <dbReference type="OMA" id="HYYINDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="40432" checksum="68533820AB252774" modified="2017-01-18" version="1">MDDTTKHFTLAKLLASSRRWMHEAMRHAAAEPPAQDLAVHHAQVAAEHLLKGFIADKHPALIAANATMLMHATGALRDRTEHAAQRPLEAGASITAREAFDTAREFTKLLDRVSNQRWTAAVSARNGVAHVGLADPTTAEEHMVTCFDIVDALLDSLGRSREEYWGTWISMRDTLGKAYLDEATRRLQARLARARARFQEQFGGQDPRFGEPVTVAMLPLLWSQQGLLGPGTSGRSAPCPAKGHSGMLLGHNLPQHYDDTERARVFVSHSYFCQICGLTAQIDEFEPLGLPLSLDIAEDGRVVSPPDRDPSHWHEVLHSAREAKNAVLDQEIADGVWCGFPGLDCACDRGWPTPPACERQSKMETNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW9</accession>
    <name>A0A1E7NAW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558089.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000665.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7572"/>
    <dbReference type="REBASE" id="196753">
        <property type="entry name" value="SauDM1ORF3290P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78072">
        <property type="protein sequence ID" value="ARF78072"/>
        <property type="gene ID" value="B6264_03295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37794">
        <property type="protein sequence ID" value="OEV37794"/>
        <property type="gene ID" value="HS99_0024700"/>
    </dbReference>
    <dbReference type="OMA" id="TEKTHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037057">
        <property type="entry name" value="DNA_rep_MutH/T2_RE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015210">
        <property type="entry name" value="NaeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09126">
        <property type="entry name" value="NaeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="35278" checksum="A36B5CD0C8094E84" modified="2017-01-18" version="1">MTPADALFAVSPALPLDAELVRVRAAILAADPQGEIFAASLRRTFDMLLDGQHTGRFRWEDLHKTEKTHAGTLVEINLQRAFEFADGDKMDYSIDGIDVDCKYSQDLGRWMIPPEAMGHLCLGVWANDNAGLWSAGLFRVTDEVLTKKDGNRDGKRSLTSAARKTAVHWLFEDAPLPENILLRLPEEDIAAIFASRYGTQRVHELFRRTQGRIVSRGVVATVAQQDDFMKRVRYNRGSREALRPEGIVILGQYKNHQAVARALGLPVPGVGESVSVRLAPWTPEHVDAQWVELEGIKWVVARENDPAVEAPLLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF3</accession>
    <name>A0A1E7NBF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278296.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2072"/>
    <dbReference type="EnsemblBacteria" id="OEV38019">
        <property type="protein sequence ID" value="OEV38019"/>
        <property type="gene ID" value="HS99_0024035"/>
    </dbReference>
    <dbReference type="OMA" id="WWERLND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="38649" checksum="D928B18C73C4BFCA" modified="2017-01-18" version="1">MGTLSPPVPRSALVEVLARFRVGRLLTAEPVAEGLLNRGYRVTTEAGDYFLKCYVDTATASRPKILAHHRAMTDLNALGLPVVPPLSCADRGGTVAAPNGRMFALFPWVDGRHRHGTELEPARCDALGTLLGRLHGALDDVCAPLDPPAGYRSADPLDSAELARELRRRAREHRPYDDLDALVEQRLGERLELLAEHAHRRPDPLDAPPTGWTHGDFHGLNLLYDEGPDGERVAAVLDWDKLGPQPRAEEAVRAATLLFNDRTTGTLDLVRVRRYSQAYRASGAATAEHLAAAVHRVWWERLNDFWMLQWRYQRADHRADPLYPASAGQLAWWCQEYEQVLDAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP3</accession>
    <name>A0A1E7NBP3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2132"/>
    <dbReference type="EnsemblBacteria" id="ARF79443">
        <property type="protein sequence ID" value="ARF79443"/>
        <property type="gene ID" value="B6264_11390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37893">
        <property type="protein sequence ID" value="OEV37893"/>
        <property type="gene ID" value="HS99_0023725"/>
    </dbReference>
    <dbReference type="OMA" id="PICPECM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="31285" checksum="B2D7E7DAB3571529" modified="2017-01-18" version="1">MLPDEPRQSTDRSPEGGPPGCYRHPQTATGISCTRCERPICPRCMVGAAVGFQCPECVGGGHAGTRRATTRFGGALTVDGGVVTRALVGINIVVWVLAAYVLNPRLGEVWSLASAGRAHPGGPYGVADGPAQWYRLLTATFLHLQWWHVGLNMLVLLWLGPPLEEALGRLRYLALYLLAGLGGSTFAFLVAGDWMNSVGASGAVFGLIGATIVMQLRNRGPLAPAVAFLVFNLVVTFSRQNIDWRAHIGGLVVGGLVALGLMYAPRERRGAVQALTVVGAVAVEAAMLLSGMALYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR8</accession>
    <name>A0A1E7NBR8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3000"/>
    <dbReference type="EnsemblBacteria" id="OEV38094">
        <property type="protein sequence ID" value="OEV38094"/>
        <property type="gene ID" value="HS99_0023120"/>
    </dbReference>
    <dbReference type="OMA" id="QCATREL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="17247" checksum="188BB49DC7492DDC" modified="2017-01-18" version="1">MRSREEWLASLPRIYAAAGCLLRDESGRILIVKAGYREHWQFPGGTIDLGEGPVECAVRELEEETGIVKEAGDLLAISWTHASAELDHPAQHFMFDFGTVPDGTPVTVPAGELDTHRWASTQEAMELLGPARSARLRAALEAAVDGRVRIVTTHVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT1</accession>
    <name>A0A1E7NBT1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000474.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7129"/>
    <dbReference type="EnsemblBacteria" id="ARF82795">
        <property type="protein sequence ID" value="ARF82795"/>
        <property type="gene ID" value="B6264_12645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38150">
        <property type="protein sequence ID" value="OEV38150"/>
        <property type="gene ID" value="HS99_0023445"/>
    </dbReference>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15815" checksum="73F49550CF804D94" modified="2017-01-18" version="1">MTTLKEQLQEDLTAAIKDRDELRSSTIRLTLSAVTSEEVAGKEKRELSDAEVLKVITREAKKRREAAEAFDQGGRVDQAARERAEGEVLAGYLPKQLSDEELAAIVAAAVAESGASGPQAMGAVMKLVKPKVDGLAEGGRVAAAVKAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC23</accession>
    <name>A0A1E7NC23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1758"/>
    <dbReference type="EnsemblBacteria" id="OEV38240">
        <property type="protein sequence ID" value="OEV38240"/>
        <property type="gene ID" value="HS99_0022095"/>
    </dbReference>
    <dbReference type="OMA" id="EGPNAWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="253"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="686" mass="75400" checksum="C49BE2D86754F0CF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC29</accession>
    <name>A0A1E7NC29_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1738"/>
    <dbReference type="EnsemblBacteria" id="ARF80227">
        <property type="protein sequence ID" value="ARF80227"/>
        <property type="gene ID" value="B6264_16085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38256">
        <property type="protein sequence ID" value="OEV38256"/>
        <property type="gene ID" value="HS99_0022195"/>
    </dbReference>
    <dbReference type="OMA" id="APEKEFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="25100" checksum="83721CA5F29A354F" modified="2017-01-18" version="1">MTPENPVLPLRERKKLRTRQALIDTALELFGEHGFDRVTLDQLCESVEVSKRTFFRTFSSKEDVAAAPTQDLWTAFLEVLEDHPPQGRPLVSLYEEALVEAIGRMPSDTWAQRALASRRLAARTPSMDAHGLAFCNRVSREAAAVTERRFTLDSAEKGTAEEGIAALRVRLALDMLLSAFHQALAAWVAQPAGHTREDLTRRLRAACAELPGALAATAEPRGEEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE1</accession>
    <name>A0A1E7NCE1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0301 protein HS99_0022610</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4149"/>
    <dbReference type="EnsemblBacteria" id="OEV38366">
        <property type="protein sequence ID" value="OEV38366"/>
        <property type="gene ID" value="HS99_0022610"/>
    </dbReference>
    <dbReference type="OMA" id="IYWGGDF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00758">
        <property type="entry name" value="UPF0301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="20591" checksum="55B377D76D9E6801" modified="2017-01-18" version="1">MCGMTAAHSHGGRSHTGRLLVATPVLTDPNFARAVVLLLDHDAEGALGVVLNRPTPVEVGSVLDGWGRLVGQPAVVFQGGPVALDSALGLAVAPGEPGSGEPLGWRRVHGAIGLVDLEAPPEVLAGELGSLRIFAGYAGWSPGQLEAELESGAWYLVDCEPGDVSSPEPERLWRSVLRRQRGPLALLATYPDDPTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF4</accession>
    <name>A0A1E7NCF4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="14" type="ORF">HS99_0022715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553234.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000788.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4129"/>
    <dbReference type="EnsemblBacteria" id="ARF80142">
        <property type="protein sequence ID" value="ARF80142"/>
        <property type="gene ID" value="B6264_15560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38334">
        <property type="protein sequence ID" value="OEV38334"/>
        <property type="gene ID" value="HS99_0022715"/>
    </dbReference>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="857"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV38334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="920" mass="103542" checksum="562FB6336E5FB833" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI9</accession>
    <name>A0A1E7NCI9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283188.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene275"/>
    <dbReference type="EnsemblBacteria" id="ARF82201">
        <property type="protein sequence ID" value="ARF82201"/>
        <property type="gene ID" value="B6264_27960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38409">
        <property type="protein sequence ID" value="OEV38409"/>
        <property type="gene ID" value="HS99_0021095"/>
    </dbReference>
    <dbReference type="OMA" id="NMVERTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="25119" checksum="932DE9A1AB352588" modified="2017-01-18" version="1">MSNELTGKAALVTGGSRGIGAAVAKRLAAEGAAVALTYVRAEEQARTVVKEIEAAGGRAVAIRADLVEPEAATRAVEETVRQLGGIDVLVNNAGFLTYGPLDEVSVEELDRVLAVDVRSVFLAAQAAARHMGEGGRIISIGSCFNGRVPGANFVLQATAKTALVGLTKGLARELGPRGITATVVDPGPIDTDMNPADGDSAAFQRSLTALDRFGEAEDIAAAVAFLAGPGGRYVTGTALAVDGGYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ0</accession>
    <name>A0A1E7NCJ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386992.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene276"/>
    <dbReference type="EnsemblBacteria" id="ARF82200">
        <property type="protein sequence ID" value="ARF82200"/>
        <property type="gene ID" value="B6264_27955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38410">
        <property type="protein sequence ID" value="OEV38410"/>
        <property type="gene ID" value="HS99_0021100"/>
    </dbReference>
    <dbReference type="OMA" id="RWVELVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="512" mass="51658" checksum="655F1CC74262496E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM0</accession>
    <name>A0A1E7NCM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0021275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene311"/>
    <dbReference type="EnsemblBacteria" id="OEV38439">
        <property type="protein sequence ID" value="OEV38439"/>
        <property type="gene ID" value="HS99_0021275"/>
    </dbReference>
    <dbReference type="OMA" id="CRQVIVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="36714" checksum="984EF1621AA7CD9A" modified="2017-01-18" version="1">MDEDDQRDERAADRSPLLEVRNLVKRFPVRHGLTQRLAGHVAAVDGVSLTVGPGETLGLVGESGCGKSTVAKLITRLERPTSGSIHFAARDLAGLNETALRPLRRDLQMVFQDPFSSLNPRHTVRQILAGAYRYQGLEPDQPAEELLARVGLEAGHADRHPHEFSGGQAQRIGIARALALRPKLVVCDEPVSALDVSVQAQILNLLRDLQDEYGLSYLFIAHDLGAVRQISTRIAVMYLGSVVETADRDTLFAQPAHPYTHALLSAVPLPDPDLEASRERIVLHGDLPSPLDPPSGCRFRTRCLKADELCAAERPQLRTIALGQQVACHYPERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND51</accession>
    <name>A0A1E7ND51_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0020380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene602"/>
    <dbReference type="EnsemblBacteria" id="OEV38620">
        <property type="protein sequence ID" value="OEV38620"/>
        <property type="gene ID" value="HS99_0020380"/>
    </dbReference>
    <dbReference type="OMA" id="WAITASF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="25"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="474" mass="49811" checksum="51CA08E8F4FA2240" modified="2017-01-18" version="1">MSVTQKPSGAAEATAPGRLGFVVFITAAAALGGFLFGYDSSVINGAVSGIQGKFGVGSGETGLIVSSALLGSAVGAALAGRFADRYGRIKVMKAGALLFAVSAVGSMLPFSPWDLALWRVLGGAAIGIASVIAPTYIAEVAPTKYRGRLASFQQAAIVLGIAISQLVNWVLADAAGGDTRGHLLGLEAWQWMLGICVVPAVVYFVLSSVIPESPRYLIQAERLDEARKVLTEVEGDGIDTDARIAEIQSLIASDHRPRFRDLLGGRFGLLPIVWVGIGLSVFQQLVGINVIFYYSSILWQSVGIDQSNSLLISFIGSVINILGTVIAILLVDRVGRKPLALIGSAGMAVTLAAAGWAFSSATGSGDNVSLPDLQGTVALISANAFVLFFAMSWGVVVWVMLGEMFPNRVRAAALSVAASAQWIANWVITVSFPSLSRWNLSATYLVYAAFAALSIVFVAKFMKETKGVRLEDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND91</accession>
    <name>A0A1E7ND91_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282918.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000440.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1764"/>
    <dbReference type="EnsemblBacteria" id="ARF77678">
        <property type="protein sequence ID" value="ARF77678"/>
        <property type="gene ID" value="B6264_00970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38645">
        <property type="protein sequence ID" value="OEV38645"/>
        <property type="gene ID" value="HS99_0020555"/>
    </dbReference>
    <dbReference type="OMA" id="YEVAHVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="29612" checksum="6DCF65133C6CC42C" modified="2017-01-18" version="1">MTVRIATWNINSVTARLPKLLEWLESARPDVLCLQELKCAADAFPYEQVRELGYETAAHGTGRWNGVAIVSRLGLEDVVRDLPGQPGYLADGALLPDVEPRAIAATCGPVRVWSVYVPNGREVDHAHYRYKLEWLEALRKAAAADAAGPRPFAVLGDFNIAPTDEDVFDVAAFEGLTHVTPVERAALEALGEIGLHDVVPRPLKYDRPYTYWDYRQLAFPKNRGMRIDLTYGNKPFVDAVTDSYVDREARKGKGTSDHAPVVVDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC9</accession>
    <name>A0A1E7NDC9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000703.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1815"/>
    <dbReference type="EnsemblBacteria" id="OEV38685">
        <property type="protein sequence ID" value="OEV38685"/>
        <property type="gene ID" value="HS99_0020805"/>
    </dbReference>
    <dbReference type="OMA" id="VFERTYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="522"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1030" mass="107587" checksum="7B6AFABF630445F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE40</accession>
    <name>A0A1E7NE40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557325.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83197">
        <property type="protein sequence ID" value="ARF83197"/>
        <property type="gene ID" value="B6264_30095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38971">
        <property type="protein sequence ID" value="OEV38971"/>
        <property type="gene ID" value="HS99_0017835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13926" checksum="4C71A63BDFB860C8" modified="2017-01-18" version="1">MLEEFEQTAEPWREAFEDLDEDVLAETAAEARSFGADPAAAVDELVRALLGQLDHWQQAIGEVGRALTAAAQERPLPEWAADAGRTEDVRWRRARQALLEAIARHHHGTLPAGRPAVVITGARRAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI4</accession>
    <name>A0A1E7NEI4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000112_gene4049"/>
    <dbReference type="EnsemblBacteria" id="ARF83353">
        <property type="protein sequence ID" value="ARF83353"/>
        <property type="gene ID" value="B6264_31025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39126">
        <property type="protein sequence ID" value="OEV39126"/>
        <property type="gene ID" value="HS99_0018755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="76" mass="8087" checksum="6448873CB9D01D1E" modified="2017-01-18" version="1">MSMTPVRPWRRNSLPVGVIGIVVIILLIGVLAVGEPSVLANPIISAAATGVVGAAAGFVTRRALRSRTRLRWQLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX1</accession>
    <name>A0A1E7NEX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285040.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3581"/>
    <dbReference type="EnsemblBacteria" id="ARF82448">
        <property type="protein sequence ID" value="ARF82448"/>
        <property type="gene ID" value="B6264_29440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39250">
        <property type="protein sequence ID" value="OEV39250"/>
        <property type="gene ID" value="HS99_0000575"/>
    </dbReference>
    <dbReference type="OMA" id="RMTEMCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="37871" checksum="E056A4F750FF1254" modified="2017-01-18" version="1">MDRPAALRLDANASGHPAGILDAAEQAERRGMDRLVVAETAYDPFLQLARAADRTESIELATGIAVAFARTPMTLAYQAWGLHAASGGRAVIGLGSQVKPHIEKRFGMPWDRPAARMREYVHAVRAIWHSWQTGERLRFRGEFYTHTVMTPVFSPDPVPAGVPRILLAGVGPLMTRTAGAVADGFLAHPFSSTAYLAEQVLPGLTEARRQAEAEGAGWTGRPFETVGNVLTAVGRTEEELAANRAGVRERLAFYASTPAYRPVLAQHGWEDLQEELHTHSVRGRWAEMTALISDEVFDAFAVSGTVEEAAREIHRRYAGLVTRLSVHLPEDADQVLGLDVLAAVRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX3</accession>
    <name>A0A1E7NEX3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550188.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82449">
        <property type="protein sequence ID" value="ARF82449"/>
        <property type="gene ID" value="B6264_29445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39251">
        <property type="protein sequence ID" value="OEV39251"/>
        <property type="gene ID" value="HS99_0000580"/>
    </dbReference>
    <dbReference type="OMA" id="KHPGWFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="30776" checksum="18C6A532A8D8EC9B" modified="2017-01-18" version="1">MTGLPLPPVPEPYHLPFHYGALHTIGVDYLVEPERARRLLAKRHPGLSVAAFDGGACVSLNYQLYFAQYPNGGGITQELEINLIAHPVFAEDRIPAVNYGQYARGYDQSKLLGSARLHVLCDNPLAIDAGRRLYAEPKHPGWFETTVPSLNAPAVRERWAVSCRRAVLGTEGLRRHQEEVIALDVDLVGLTPESVNSTPITGYGTDDEGKLLAGPLNAHQPYRYYALDDRSADRVRLDLGNPAEEPARDLAQLVGDAPAAGVWTYQSAPVAARNRAYYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEY4</accession>
    <name>A0A1E7NEY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000146.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39234">
        <property type="protein sequence ID" value="OEV39234"/>
        <property type="gene ID" value="HS99_0000460"/>
    </dbReference>
    <dbReference type="OMA" id="SVWAIFD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41104" checksum="44CD22A92CE8B87B" modified="2017-01-18" version="1">MSNNSAVVVGGGIGGLATAIGLRLAGWDVTVIERAAVLDDAGAGISLHANGMRSLGILGVGDAVEAASRRQYTGGTRTPDGRRLALMDGRALERELGAPIVGIPRADLHRILRDALPAESLVIGAEVTEIDATDPARVAVGYDGTTLKADLVVAADGVNSRIRHRLFPAHPGPVYSGSTVLRAITERPVDGLTADFELTWGHGAEFGHIAFPDGRAEWHAVLNAPAGVRYRDPLTEVRRRFARWHDPIPALLAATNPEAVLHHDVNELVTPLPSYVSGRIALLGDAAHAMTPHLGQGACQALEDAATLAAAVAGSPTVEAALARYDAARRPRSQTVARDARRAGRMGQQLANPLAVGLRNAAIRLTPPGAMMRTVLKHADWTPPRIAPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ8</accession>
    <name>A0A1E7NEZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3584"/>
    <dbReference type="EnsemblBacteria" id="ARF82451">
        <property type="protein sequence ID" value="ARF82451"/>
        <property type="gene ID" value="B6264_29455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39252">
        <property type="protein sequence ID" value="OEV39252"/>
        <property type="gene ID" value="HS99_0000590"/>
    </dbReference>
    <dbReference type="OMA" id="YELKARI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="20053" checksum="5DC3AD77E6606FB0" modified="2017-01-18" version="1">MLTLAILGFLYDQPLHGYELKSRITGLTGHVRPVSDGALYPAITRLEKAGLLHRRTEPGTGAAPRQTLELTEEGRAELLRRLADPEQAEITDQIRFFTLAAFLHHLADPLQQAEVLRRRLAFLEAPSSFFYDGDGRPVTAEREPNPFRRGMLLVARASTAAERAWLAETVTGLTGADGPKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF08</accession>
    <name>A0A1E7NF08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3626"/>
    <dbReference type="EnsemblBacteria" id="OEV39289">
        <property type="protein sequence ID" value="OEV39289"/>
        <property type="gene ID" value="HS99_0000805"/>
    </dbReference>
    <dbReference type="OMA" id="VWEIAYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20664" checksum="53A1BF2E60B7272F" modified="2017-01-18" version="1">MARWQPDAPGRLAAAALDLFEEHGYENTTVIEIAERAGLTKSTFFRYFPDKREVLFDKGTLTGVLVEGITSAPPAAGPLDAVADALDELGRTFFTADRREFSGRRQAVLNANSELREREALKRLDLTASMIEALGRRGVPSLTARVAAELGTLVWEIAYDRWIDTDNSEGFGPLARQALAEVRGAAGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD6</accession>
    <name>A0A1E7NFD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550140.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000410.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3517"/>
    <dbReference type="EnsemblBacteria" id="OEV39203">
        <property type="protein sequence ID" value="OEV39203"/>
        <property type="gene ID" value="HS99_0000270"/>
    </dbReference>
    <dbReference type="OMA" id="GDEFGHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="13"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="32923" checksum="1AE0E054D9FC851D" modified="2017-01-18" version="1">MPGAAVTSPASAVVVIGECVADIVRTDGAPDRVHPGGSPANLAYGLARLGRPAVLVTELGPDANGRLIRTHLESAGVEVRAAEVARTPSALVRLDGQGRAQYTFDIGWTLPPTELSEAPAAIHLGSIGAVTEPGAASVLALVRRWRGRTQVSYDPNVRPALMGERAEAVCRVERCVALSDLVKASDEDLGWLYPGEPVEAVAERWLTLGPAVVAVTLGAEGAVALTAEGRRERVAAVPVPVADTVGAGDSFMAAFLHARACGADLADCLTRAVTAAAVTVSRPGANPPSAAELADALGRLADADAVSSRTRPFDSATGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFP1</accession>
    <name>A0A1E7NFP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0001875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386379.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5101"/>
    <dbReference type="EnsemblBacteria" id="OEV39468">
        <property type="protein sequence ID" value="OEV39468"/>
        <property type="gene ID" value="HS99_0001875"/>
    </dbReference>
    <dbReference type="OMA" id="MWIYFSS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="35464" checksum="747F536D5AA03EDD" modified="2017-01-18" version="1">MNPVERTLRALDRAQQHHTVPGMVVGVIKKYGDDRGSLLTALIAYYGFMALIPLLLLLSTILSFILHGHPGAQKTIVNSALADFPIIGDQLRQNVHSVQGSGLALVVALLGLVYGALGIAQVLQHAMAEVWNVPGVVRPGYFPRLARSLLLFSTLAVGLLLATAAATLVATTLGGLAAHIGALVLSAVVNTGLCLACFRILTPKIISTRALLPGCAIAGPLFTVLQAFGAALVAHQLRHATAVYGFFATVIGLLSWLALAATITVYAAETNVVLHRRLWPRSILQPPLTEADEKVLESIANQEERRPEQHVDVDFDDDNTSPEDGRPHQDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFQ9</accession>
    <name>A0A1E7NFQ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0002090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5057"/>
    <dbReference type="EnsemblBacteria" id="OEV39504">
        <property type="protein sequence ID" value="OEV39504"/>
        <property type="gene ID" value="HS99_0002090"/>
    </dbReference>
    <dbReference type="OMA" id="ENDHYDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="163"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="713" mass="73114" checksum="CAC81393EBB7C11E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX1</accession>
    <name>A0A1E7NFX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-butyrolactone-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000784.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6712"/>
    <dbReference type="EnsemblBacteria" id="OEV39577">
        <property type="protein sequence ID" value="OEV39577"/>
        <property type="gene ID" value="HS99_0002545"/>
    </dbReference>
    <dbReference type="OMA" id="AFRNVCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="25150" checksum="29A782C52F836F1D" modified="2017-01-18" version="1">MVRQERALRTRRLILEAAATVFDEFGYEGATIGEVVSRAGVTRGAVYFHFASKRELAQGVVEEQFVQDGVPERSCKLQEFVDTGMTVAHLMPRNPLLSAGARLSLGQDASDDFGGGAIPGWIGRMEALLVAAGERGELLPHVVPADTAWLVTAAWTGVQIQSQKLCGRADLERRVSGLFQHLMPSVAVPGVLGSLQMGPDRGAQVVAEVAAARAAWEGGGGSSAKSRTGGEVVVNGAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG70</accession>
    <name>A0A1E7NG70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385608.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2827"/>
    <dbReference type="EnsemblBacteria" id="OEV39677">
        <property type="protein sequence ID" value="OEV39677"/>
        <property type="gene ID" value="HS99_0003165"/>
    </dbReference>
    <dbReference type="OMA" id="IHVMRFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="38472" checksum="43CEC8FEA49A3BBA" modified="2017-01-18" version="1">MKSDDSPPHPDRPAGAVRLEGLAKSFDGRVRAVDGVDLEIGEGEFFAMLGPSGSGKTTVLRMIAGFERPTAGRVLLGGVDVTALPPFDRDVNTVFQDYALFPHMTIEQNVGYGLMVRRVPKAERAERVRAALAMVRLEGFERRRPAQLSGGQRQRVALARALVNRPKVLLLDEPLGALDLKLRHEMQAELKRIQREVGITFVFVTHDQDEALTMSDRVAVFNAGRIEQVGSPAEVYEHPATAFVAGFVGTSNLLDGAAAEQVVGETGLFSVRPEKIRIAHPDDPAGPDELSATGRVAEVVYAGGHTRFLVDLEAGGRLTAVRQNLDEGSADVLRHRGTDVVLAWQRKHTVRVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL9</accession>
    <name>A0A1E7NGL9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoglucanase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0003090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2812"/>
    <dbReference type="EnsemblBacteria" id="OEV39861">
        <property type="protein sequence ID" value="OEV39861"/>
        <property type="gene ID" value="HS99_0003090"/>
    </dbReference>
    <dbReference type="OMA" id="TWNTWDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199132" description="Endoglucanase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="50527" checksum="358EE1FA3B4C8D6F" modified="2017-01-18" version="1">MAVLPLTASATTSSPTPASGTSCDVKYAVNDWGSGFTANLTITDTGTLPINGWTLGYSYTGNQTLQNGWNGTWSQSGQAVTVTNPGYAPTIDPGATYTTSANFSYNGTNTAPTAFTLNGTPCGPRSSPSPSPSPTPTSTPPTTPPPNGSAPAVHVAGRTLAKADGTPITLHGVDRSGAEFMCVQGHGFFDGPADQASVTTMKSWHVNSVRVPLNEDCWLGHSNVDPAYAGAAYIGAVRSYVDLLERNGLVAVLDLHWTDGVYTGPSAGCPDANATCQKPMPDAAGAIPFWTSVAQTFKGDDAVVFDLFNEPYPSRATGSEDSGWTCWRDGGSCPGIGYRVAGMQAMVDAVRSTGADNVLMLGGQEYANDLTQWAAHQPADPLHNLAASWHSYNFNACSTTSCWDGQIAPLTAQVPVIAGEFGENDCAHGYLDALLPWLDQHGVSYLAWTWNTWDCSNGPALISSYDGTPTAFGAGYRAHLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM2</accession>
    <name>A0A1E7NGM2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39844">
        <property type="protein sequence ID" value="OEV39844"/>
        <property type="gene ID" value="HS99_0002575"/>
    </dbReference>
    <dbReference type="OMA" id="HGSIRYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="29788" checksum="06A19120EC50BD33" modified="2017-01-18" version="1">MARPSAAPAAVRDGRVRRDGYARLSAADLGIDTETFATDFEGLTDACRDLPPDPYARRTNRFRRYSHAVHLPWTGELSYVPGAPDDEFGTATEYWQDEHNPEYPRMRRRLPDIPPALHGNRLLEALIRADLDHALWLEDLHRVPVYVGVHLIALAVRDREQVAVSSPNCLHQDGGSPATFTFAHLLGRRNVEGGENVIATPESAGRQPDDLPPGAVHDRFFLTEPLDGYGVHDQRVSHYVGPVRLGDEEGDGRREILIVGIAPYEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP2</accession>
    <name>A0A1E7NGP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2845"/>
    <dbReference type="EnsemblBacteria" id="OEV39864">
        <property type="protein sequence ID" value="OEV39864"/>
        <property type="gene ID" value="HS99_0003255"/>
    </dbReference>
    <dbReference type="OMA" id="VECYALV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14318" checksum="B11A486A4FD58BE5" modified="2017-01-18" version="1">MSTVRPLSVTFPESAAPDVPVEAELRFDASLPYAACLAFPLTPCQCTGDGARVSWYFSRELLNEGRLGPVGSGDVKVRPGVAGEVLISLRGPGGGSLVSAPEDLVTAFLSDSFTLVPAGSESDHLDIDAALARLLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGQ2</accession>
    <name>A0A1E7NGQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0003660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2929"/>
    <dbReference type="EnsemblBacteria" id="OEV39874">
        <property type="protein sequence ID" value="OEV39874"/>
        <property type="gene ID" value="HS99_0003660"/>
    </dbReference>
    <dbReference type="OMA" id="WDELTIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="388" mass="42094" checksum="6DF9CB8A45D9D133" modified="2017-01-18" version="1">MRVQLTERQAAAREEYESFTRQAVAPHADAWDRAERLPEEFLEEFAARGLLGAAVPAGYGGAELDPITFGLLNEELGRGCSSVRSLVTVHGMASYAVARWGGDRQREHWLPRFATGGAIGAFALTEPGAGSDVKALRTTARRTDDGFRLTGQKRWITFGQRADVYLLFARLDGREAAFLVPRDAPGLTVRPVTGMLGTKASMLAELSLVDCLVAPEALLGRPGFGLAAVAASALELGRYSVAWGCVGLAQACLDASLDHADRRETFGVRLRDHQLVQRMIADMATGTAAARLLCQQAGWLRQDRSTESLHATWLAKYHASRTAFRSASDAVQVHGAQGCGDGHPVQRYLRDAKVMEIIEGSTELQQTTIAESAYHSRTRTTPTERVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVH2</accession>
    <name>A0A1E7MVH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1173"/>
    <dbReference type="EnsemblBacteria" id="OEV32432">
        <property type="protein sequence ID" value="OEV32432"/>
        <property type="gene ID" value="HS99_0017255"/>
    </dbReference>
    <dbReference type="OMA" id="YEESASH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="31746" checksum="4BBB75DF821952EB" modified="2017-01-18" version="1">MGQPRPSVRRRRVASLLIRHREAADKTPDEAAARIDCHRSKISRMENAWLPISSSELRDLLTFYGVDDPAYVEEVVALNRQGSERGWAQRFDITPPSYVDYIDYEESASHIRSFQPMMVAGLLQTADYARAVYRASPFDIPPERIDELVAVRLQRQKVLDHAEPPRLSVILGEASLRGHVGGVHVLRKQLDHLRKLADRPNIDLQVLPFTAGAHAGIMGSFVLFSFSTAAFSDVACVEHQAGMLYMEKPEETSAYTLTFDSLRSSALSASESLDLLTRVIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK2</accession>
    <name>A0A1E7MVK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1209"/>
    <dbReference type="EnsemblBacteria" id="OEV32460">
        <property type="protein sequence ID" value="OEV32460"/>
        <property type="gene ID" value="HS99_0017420"/>
    </dbReference>
    <dbReference type="OMA" id="WPTPPGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="33217" checksum="D3AB73C5169785E8" modified="2017-01-18" version="1">MEVFECRGCGTALTGPLSRVPFPVYAGIPYGNGVAMPVLMESGTYALGIDLLDPADEGENEGSVLLAPGDAAGTRLIPGRNEGNCCGLDGYGGPNLACAGCGRPVAARIDECSAWQATWLEPDAARRVPAGPPRPVADWASVAGRWRAAALVEADGSRSIRWDVEAAVTLAHLVSAADGAPLALAPGPLAQAFRGLLGQLPPPQARPARRAALAGPGRPLPRPLPDIAVVPRHPQTGEPWPTPPGVAAAPLAAEYWAALAFHDERELAPATGRLPPGVERDDPLPPHPLYAGYLDRWVFRAVLNRLNGVDDTQDDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW20</accession>
    <name>A0A1E7MW20_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78340">
        <property type="protein sequence ID" value="ARF78340"/>
        <property type="gene ID" value="B6264_04885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32620">
        <property type="protein sequence ID" value="OEV32620"/>
        <property type="gene ID" value="HS99_0015195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="17350" checksum="5B7D0EEFEC6F64DD" modified="2017-01-18" version="1">MAVGGAVGARTAGPGLGVADHPGRLRCSGSRSTPGNRSARGTGSAPDDLTPRRPLGVELTAHRRKSPIERSPGTSGGCARCRSRAGTGRSCLMIRIAAWSAGQEAARSTLRTDLADPTPGTSSRSGTVPATANRARVRQGATGVGSTHTRSVLPSSGSSVVSRIVPSPASSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI6</accession>
    <name>A0A1E7MWI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurium resistance protein terZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3164"/>
    <dbReference type="EnsemblBacteria" id="ARF78288">
        <property type="protein sequence ID" value="ARF78288"/>
        <property type="gene ID" value="B6264_04585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32791">
        <property type="protein sequence ID" value="OEV32791"/>
        <property type="gene ID" value="HS99_0015500"/>
    </dbReference>
    <dbReference type="OMA" id="MTVNMTK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20568" checksum="6E8CD53A994CDD7D" modified="2017-01-18" version="1">MSVNLAKGQRVSLQKGAGGTLTVVRMGLGWQAAPKRGLFGSRTRKIDLDASALLYAEKTPTDVVFFQHLESTDGSVRHTGDNLEGGSGVEDDEAILVDLLHVPPHITQVVFTVSSYTGQTFAEVRQAHCRLLDETTGVELARYELAGGGPHTGQIMAKVVRDGNGGWEMQAIGAPAKGRTFQDLLPAIEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWN8</accession>
    <name>A0A1E7MWN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000082">
        <property type="protein sequence ID" value="OEV32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386051.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000205.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000098_gene26"/>
    <dbReference type="EnsemblBacteria" id="ARF82875">
        <property type="protein sequence ID" value="ARF82875"/>
        <property type="gene ID" value="B6264_16900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32855">
        <property type="protein sequence ID" value="OEV32855"/>
        <property type="gene ID" value="HS99_0039810"/>
    </dbReference>
    <dbReference type="OMA" id="WRTRNPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010219">
        <property type="entry name" value="UCP010219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24327" checksum="B12EEAB517407843" modified="2017-01-18" version="1">MDPAAAEAARRAASKEAADTVLQAFGGVRGMIDMTLPGLVFIVTYNVTHQVSAAAWAALGLSALFVVARLARRETIQHAFSGVFGVALGAWIAMKSGKAEDFYLPGLLWNVGYCIALAASALARWPMIGVMLGPITGEMFTWRKENPGRLAAYTKATWAWVVIMGLKPVILFPLYLTHNVNLLGWLKVALGIPPLLLAMYVTWQILLKAPPPIKAPVDDEEEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWT0</accession>
    <name>A0A1E7MWT0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0039635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387019.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000623.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78865">
        <property type="protein sequence ID" value="ARF78865"/>
        <property type="gene ID" value="B6264_07995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32888">
        <property type="protein sequence ID" value="OEV32888"/>
        <property type="gene ID" value="HS99_0039635"/>
    </dbReference>
    <dbReference type="OMA" id="THHPGRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="38260" checksum="1B4B27CCF651BEDF" modified="2017-01-18" version="1">MTTVIENDSQKSGRLEVGTPLLEVKDLHVEFHTRDGVAKAVNGVNYSVAAGETLAVLGESGSGKSVTAQTIMGILDMPPGKVTQGEILYRGQDMLKMSNEERRKIRGRKIAMIFQDALSALNPVLSVGYQLGEMFRVHQGVSKAEAKAKAIELMDRVRIPAAKERVNDYPHQFSGGMRQRIMIAMALSLQPDLIIADEPTTALDVTVQAQVMDLLAELQAEYNMGLILITHDLGVVADVADKIAVMYAGRIVETAPVHELYANPAHPYTKGLLRSIPRLDQKGQELYAIKGLPPNLLKVPAGCAFNPRCDVATDLCRTEIPALHHVTDKDGKELTGRRSACHLWKETLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX38</accession>
    <name>A0A1E7MX38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279861.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5695"/>
    <dbReference type="EnsemblBacteria" id="ARF81424">
        <property type="protein sequence ID" value="ARF81424"/>
        <property type="gene ID" value="B6264_23155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33006">
        <property type="protein sequence ID" value="OEV33006"/>
        <property type="gene ID" value="HS99_0014125"/>
    </dbReference>
    <dbReference type="OMA" id="VFQRPFV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="23993" checksum="ADD843B3082ADBA2" modified="2017-01-18" version="1">MTPVIEARDLALAFGETPALRGASLSVGAGEVLAIMGPSGSGKSTLLHCLAGILVPDAGEVLFNGQRLDSMSEARRSALRRDQFGFVFQFGQLVPELTAEENVALPLLLNGVRRGAALAQARPWFARLGLDGMENRRSGELSGGQAQRVALARGLVARPQVLFADEPTGALDSLTGEQVMELMVAAAREQGTTVILVTHEPRVAAYADREAIVRDGQARTLSAGPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX42</accession>
    <name>A0A1E7MX42_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0014090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552471.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5702"/>
    <dbReference type="EnsemblBacteria" id="OEV33000">
        <property type="protein sequence ID" value="OEV33000"/>
        <property type="gene ID" value="HS99_0014090"/>
    </dbReference>
    <dbReference type="OMA" id="ETRIGDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="339"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="913" mass="93060" checksum="AE685CB1ACEF405E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM9</accession>
    <name>A0A1E7MXM9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="10" type="ORF">HS99_0039490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738003.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000142_gene3681"/>
    <dbReference type="EnsemblBacteria" id="ARF78121">
        <property type="protein sequence ID" value="ARF78121"/>
        <property type="gene ID" value="B6264_03595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33186">
        <property type="protein sequence ID" value="OEV33186"/>
        <property type="gene ID" value="HS99_0039490"/>
    </dbReference>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
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        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
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        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
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        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="355"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
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            <position position="468"/>
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        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="545" mass="59556" checksum="A9B3187D9881BA9F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXN8</accession>
    <name>A0A1E7MXN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387642.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2695"/>
    <dbReference type="EnsemblBacteria" id="OEV33174">
        <property type="protein sequence ID" value="OEV33174"/>
        <property type="gene ID" value="HS99_0014795"/>
    </dbReference>
    <dbReference type="OMA" id="DWRYRAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
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        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198623" evidence="1">
        <location>
            <begin position="29"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="192"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="55653" checksum="5EF231659FFE2DC6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS2</accession>
    <name>A0A1E7MXS2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Gluconokinase</fullName>
            <ecNumber evidence="4 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0039115</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4 9"/>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386646.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000443.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5906"/>
    <dbReference type="EnsemblBacteria" id="ARF82070">
        <property type="protein sequence ID" value="ARF82070"/>
        <property type="gene ID" value="B6264_27160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33232">
        <property type="protein sequence ID" value="OEV33232"/>
        <property type="gene ID" value="HS99_0039115"/>
    </dbReference>
    <dbReference type="OMA" id="ENFIQVS"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="PTHR43442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19620" checksum="9D1165F814553A12" modified="2017-01-18" version="1">MALNVENRALPDAPRTVVVMGVSGVGKTTLARLLADRLDLPFAEADEFHPPANIAKMSAGIPLDDQDREPWLRAIGAWLKAHTEAGTGGVVTCSALKHSYRDILRADAPDAFFLHLSGGHELVGDRLSHRTGHFMPTSLLDSQYATLEPLGADENGAVLDVGPSPEELVEMAVALLRPVNGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY16</accession>
    <name>A0A1E7MY16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283877.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3407"/>
    <dbReference type="EnsemblBacteria" id="ARF80438">
        <property type="protein sequence ID" value="ARF80438"/>
        <property type="gene ID" value="B6264_17360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33337">
        <property type="protein sequence ID" value="OEV33337"/>
        <property type="gene ID" value="HS99_0012130"/>
    </dbReference>
    <dbReference type="OMA" id="QQMRGWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="34424" checksum="2BB506DC596B256B" modified="2017-01-18" version="1">MARKSAPDDLLAPLTLAVGQEELLLDRAVAQVVAAAKAADPDTDVRDLPPGGLQPGSLAELTTPSLFAERKVIVVRAAQDLSAESVKEVKAYIESPAEEVIMVLVHAGGAKGKGLLDAGRKAGGREVACAKLAKASERLAFVKGEFRALGRSATQEACQALLDALGSDLRELAAACSQLTSDVEGTIDETVVARYYSGRAEATGFEVADLAVTGRAAEALERLRWALAVGQPPTGITYALASGVRSIGRLATAGRNMRPADLARELGMPPWKVDRVRQQMRGWTGDGVATALTAIAQADAAVKGGSDDPAFALECAVVAVAKAARAGSRPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYG1</accession>
    <name>A0A1E7MYG1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0038965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283785.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000232.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4510"/>
    <dbReference type="EnsemblBacteria" id="ARF80409">
        <property type="protein sequence ID" value="ARF80409"/>
        <property type="gene ID" value="B6264_17185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33273">
        <property type="protein sequence ID" value="OEV33273"/>
        <property type="gene ID" value="HS99_0038965"/>
    </dbReference>
    <dbReference type="OMA" id="HDYQKKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="42243" checksum="FB45AF66A427038C" modified="2017-01-18" version="1">MSSYGSYRQLRLTPQRSGVSKALAKDSPLWRLDWILLLAGLALSAGSSMLVWSATRGRDNLTHGDPQYFLYRHLTNFVIGLVLCAVVIGIGARRVRTLVPFVYVGVIVLLLATLSPVGSTVNGAHSWIQLGGGFSVQPAEFAKIAILLAMAVVLSDQVDAGEREVPSHRAVFRGLFWACLPMGLVLLMPDAGSVMVMSAVVLGILLGSGAANRWVLGILALGVGGSIAIWKLGLLSQYQIDRFAAFANPQLDPNGVGYNTAQARIAIGSGGLTGKGLFHGTQTVGQFVPEQQTDFVFTVAGEELGFVGALAIIALVGVILWRACRIARQATDLYGTIVAAGIIAWFSFQAFENIGMCLGIMPVAGIPLPFVSYGGSSMFAVWIGIGLLQAVRSQRPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYH2</accession>
    <name>A0A1E7MYH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555553.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6611"/>
    <dbReference type="EnsemblBacteria" id="ARF80573">
        <property type="protein sequence ID" value="ARF80573"/>
        <property type="gene ID" value="B6264_18150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33469">
        <property type="protein sequence ID" value="OEV33469"/>
        <property type="gene ID" value="HS99_0012930"/>
    </dbReference>
    <dbReference type="OMA" id="TMTVFNY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22094" checksum="1410E976F23A92D5" modified="2017-01-18" version="1">MGLRELKKQQTRELLADTAMGLFAERGFEQVTVVEVARAAGVSPNTVFNYFPTKEDLFFDRQDEVVAHLAEVVRRRPAGSSAVDAVRADLLTGVADGDPTVGLNPGISAFWRIIADSPALRARLLELGERAEAALATALAEESGAGPEDPLPRIVAGAVAGAHRAVLVEIRRAMVAGEPAEAVRERIEAAVERAFGLLGSGLAGYPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG2</accession>
    <name>A0A1E7MZG2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">HS99_0037735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283759.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000513.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4495"/>
    <dbReference type="EnsemblBacteria" id="ARF80397">
        <property type="protein sequence ID" value="ARF80397"/>
        <property type="gene ID" value="B6264_17110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33817">
        <property type="protein sequence ID" value="OEV33817"/>
        <property type="gene ID" value="HS99_0037735"/>
    </dbReference>
    <dbReference type="OMA" id="GFKRQDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="24642" checksum="7E66DDC59C314433" modified="2017-01-18" version="1">MNIPSLSAAKARVEDMRAEGRYIVPRFVERTTQGIREYDPYAKLFEERIIFLGSQVDDVSANDIMAQLLCLESMDPDREIQMYINSPGGSFTALTAIYDTMQYVKPDITTVCMGQAASAAAVLLAAGTPGKRMALPNARILIHQPYTETGRGQVSDLEIQAKEIFRMREQLEEMLSKHSNKSVEQVRDDIERDKILTAEEAVEYGLVDQIISTRKTSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ6</accession>
    <name>A0A1E7MZJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551280.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000751.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6356"/>
    <dbReference type="EnsemblBacteria" id="ARF78768">
        <property type="protein sequence ID" value="ARF78768"/>
        <property type="gene ID" value="B6264_07415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33857">
        <property type="protein sequence ID" value="OEV33857"/>
        <property type="gene ID" value="HS99_0037230"/>
    </dbReference>
    <dbReference type="OMA" id="WRFVAQK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl_transf_3" evidence="1">
        <location>
            <begin position="53"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="2">
        <location>
            <begin position="448"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="737" mass="79109" checksum="EFF137D9FC6E0636" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV6</accession>
    <name>A0A1E7MZV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385746.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77820">
        <property type="protein sequence ID" value="ARF77820"/>
        <property type="gene ID" value="B6264_01760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33964">
        <property type="protein sequence ID" value="OEV33964"/>
        <property type="gene ID" value="HS99_0010915"/>
    </dbReference>
    <dbReference type="OMA" id="VKYLMST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="16694" checksum="BD9432E8D5B56CBC" modified="2017-01-18" version="1">MKGIVSKVALGVAGTGMAVAVAAVAIGPRVSEWYDGRHQEQASYDSGSQAKAERRSVPAWLPDNASSVKYLMSTTGDDRLLRATLPEGRLPAGCSTGVSGRGPHPLPVSLKAGWFPEGVAAKAVGTCGHYNVTLTGNQLYAWQDGATLQAALRAEHVAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV7</accession>
    <name>A0A1E7MZV7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2194"/>
    <dbReference type="EnsemblBacteria" id="ARF77825">
        <property type="protein sequence ID" value="ARF77825"/>
        <property type="gene ID" value="B6264_01790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33969">
        <property type="protein sequence ID" value="OEV33969"/>
        <property type="gene ID" value="HS99_0010945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="11481" checksum="37D910C82D4B4412" modified="2017-01-18" version="1">MVVEETVGVGRDRTWGSKVLGEVEGTREEAVAELRRIVPTYTPEHPMNSRRQTLLRDGDTYLLISQGSMRDYHCVFKVWEMLWDSKRPEVQAERLTEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N053</accession>
    <name>A0A1E7N053_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280045.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2323"/>
    <dbReference type="EnsemblBacteria" id="ARF77928">
        <property type="protein sequence ID" value="ARF77928"/>
        <property type="gene ID" value="B6264_02415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34070">
        <property type="protein sequence ID" value="OEV34070"/>
        <property type="gene ID" value="HS99_0011565"/>
    </dbReference>
    <dbReference type="OMA" id="EWARHIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="27041" checksum="8114BF5C8C148ACE" modified="2017-01-18" version="1">MDFPRALRGRRTDRRLSQLDLATRAGTTQRHLSFIESGRSTPGRGMVVRLAESLDLPLRERNELLLAAGYAPAYPESPLDGPRLAPVRAAIDHLLAGHLPYPALVVDRRGDVVAANEALDVITAGADPSLVGPGTNAYRLALHPDGLAPRILNFAAWARHIVEGTRHLGELHEELSAYVPEVAVGDQHLGFAVPLELRTSLGELHLMTTVTTFATAVDVTLAELKLEAFLPADARTAELLLRARGTGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N092</accession>
    <name>A0A1E7N092_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">HS99_0011750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289986.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2363"/>
    <dbReference type="EnsemblBacteria" id="ARF77962">
        <property type="protein sequence ID" value="ARF77962"/>
        <property type="gene ID" value="B6264_02605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34102">
        <property type="protein sequence ID" value="OEV34102"/>
        <property type="gene ID" value="HS99_0011750"/>
    </dbReference>
    <dbReference type="OMA" id="GTGFYYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="54" mass="6502" checksum="3E59B38DF48DE5FD" modified="2017-01-18" version="1">MARNDLRPIIKLRSTAGTGYTYVTRKNRRNDPDRLVLRKYDPVLGRHTEFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G6</accession>
    <name>A0A1E7N0G6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0011530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2316"/>
    <dbReference type="EnsemblBacteria" id="OEV34172">
        <property type="protein sequence ID" value="OEV34172"/>
        <property type="gene ID" value="HS99_0011530"/>
    </dbReference>
    <dbReference type="OMA" id="LVIMYLQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="467" mass="48598" checksum="1A8C1402B735C988" modified="2017-01-18" version="1">MLVVMIGVLIAAIDSTIVVLALPEIQHDLDVSLTAVTWVVVAYLLVVTVLATQVGRLGDMYGRVRMYEAGFVVFTVGSVLCALAWNAPSMIGFRVVQGLGAALIAANSGAVISELYPPQERGRAYGLNALVFSLGSVLGVLLGGVIVTYVSWRWIFWINLPVGLVALVLAARVLRDRGERVRRRLDPLGMATLGLGVFGISWAMTRLAVEPPDAAQIGALAGGAALLGVFVLVELRHPEPTLDLSLFRIPGMTPSLVASLLQSLGSFAVLFLVIMYLQGPRGLSPISASLLLVPGYLVGALVGPYTGRIADRLGPVVPATAGLGISVVALLLFAQMTTGSGLWLPAVGNAVIMIGGSFFYAANSSAVMKAAPPERLGIASGVLRTFASLGMVFSFTVAILVAAHAVPRSTAFAVFVGTTSLHGADAEAFTSGLSTAFYTLTGIMVLAAALSAVRGRPDAVRRTTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J8</accession>
    <name>A0A1E7N0J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278508.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000324.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1960"/>
    <dbReference type="EnsemblBacteria" id="ARF79592">
        <property type="protein sequence ID" value="ARF79592"/>
        <property type="gene ID" value="B6264_12305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34204">
        <property type="protein sequence ID" value="OEV34204"/>
        <property type="gene ID" value="HS99_0037155"/>
    </dbReference>
    <dbReference type="OMA" id="LAWDEVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18370" checksum="5E185B8D72321669" modified="2017-01-18" version="1">MSVRPPLPYEFLPRVPSFELSSRDITEGGTLGQEFIHGGGNLSPQLSWSGLPEGTRSIAVTCYDPDAPTGSGWWHWLALNLPADTTELPRGAGSSDESLPGAASFHGRNDFPDNKYDGAAPPPGAPHRYVFAVHALDVEKLDVTADTPAAQIGFNLTFHTLGRALLTAEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q4</accession>
    <name>A0A1E7N0Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6083"/>
    <dbReference type="EnsemblBacteria" id="ARF78172">
        <property type="protein sequence ID" value="ARF78172"/>
        <property type="gene ID" value="B6264_03900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34256">
        <property type="protein sequence ID" value="OEV34256"/>
        <property type="gene ID" value="HS99_0037000"/>
    </dbReference>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="57423" checksum="D9017A56560D499D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U7</accession>
    <name>A0A1E7N0U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835484.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000332.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6396"/>
    <dbReference type="EnsemblBacteria" id="ARF78735">
        <property type="protein sequence ID" value="ARF78735"/>
        <property type="gene ID" value="B6264_07215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34317">
        <property type="protein sequence ID" value="OEV34317"/>
        <property type="gene ID" value="HS99_0036320"/>
    </dbReference>
    <dbReference type="OMA" id="PMTDWGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="28605" checksum="220ECF0C616F069F" modified="2017-01-18" version="1">MAGLRRAVVRSASAGAPYGMLRYGLRAGVFEWLLERVPTPRRTPFTLGYLAVVGATTTFAGLADPELVQRLQEASSSDGHNLLQHPLRALVLSGFWVAGEVWMPYLWGFAFTLAPLERRVGTGRAAAVFAIGHVAATLLSQGVVIAAVEAGRMAPEAMDHLDIGVSYGVLACLGAVAGLLPWRGRALALGGVGLMIAQQIATEKDVVTAVGHPAAVLTGVVLSRWLRRIERRPPRSRAREAQARTVATAASAASTASSAAAAVRAGARPSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N165</accession>
    <name>A0A1E7N165_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386144.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000234.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1423"/>
    <dbReference type="EnsemblBacteria" id="ARF79230">
        <property type="protein sequence ID" value="ARF79230"/>
        <property type="gene ID" value="B6264_10160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34411">
        <property type="protein sequence ID" value="OEV34411"/>
        <property type="gene ID" value="HS99_0035980"/>
    </dbReference>
    <dbReference type="OMA" id="QDMTRGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="22707" checksum="59A9E9D306B15A12" modified="2017-01-18" version="1">MASANSAEAPASRPSGPQYLPSSVQGAVKILVTGPFGVGKTTLVGSLSEITPLRTEETMTAASSGVDDLTGRGDKTTTTVALDFGRITLNSRLALYLFGTPGQQRFWPLWDDLSRGALGAIAMVDLRRPDESFDVLGRLEEQRIPFAVAVNTFPDTPSYPEEELRSALDVLPEVPILYCDARDRRQSYDLLIDFVDHLHRSSLLELQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A8</accession>
    <name>A0A1E7N1A8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290793.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1062"/>
    <dbReference type="EnsemblBacteria" id="ARF78950">
        <property type="protein sequence ID" value="ARF78950"/>
        <property type="gene ID" value="B6264_08485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34451">
        <property type="protein sequence ID" value="OEV34451"/>
        <property type="gene ID" value="HS99_0035710"/>
    </dbReference>
    <dbReference type="OMA" id="ANTAHRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="24795" checksum="CB02776D9BFA9A22" modified="2017-01-18" version="1">MTGLPLSAYQADDRSAVKEIQARNALIVSCMHRAGFSAFTGDGLQAAQPPDNATALPAGAWGYLGAEAAATLGFHPPKRTPPRPNPAPAGSGEAYDGARVDCDRQAAERIGSPPAAGSRLVGRLFDESTKATAKDARVVAATRQWSACMTTAGFGATTPEELPQRYQTAPEVTPAELAAARADADCTAGTELAGLWFAVLAGYQRQLIDRNAEALTAQKEAVRAQDAKLTELIAGEGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1P5</accession>
    <name>A0A1E7N1P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77534">
        <property type="protein sequence ID" value="ARF77534"/>
        <property type="gene ID" value="B6264_00075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34586">
        <property type="protein sequence ID" value="OEV34586"/>
        <property type="gene ID" value="HS99_0008775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8752" checksum="8D2DA9731DC80A39" modified="2017-01-18" version="1">MRFLEEVDVQTVHPRRRRVFRRGEEEVMVQWGLAGRRVDRGIWWTSIDVNGAYIVMAPSVEVLEVLEEQPPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N215</accession>
    <name>A0A1E7N215_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4632"/>
    <dbReference type="EnsemblBacteria" id="ARF81911">
        <property type="protein sequence ID" value="ARF81911"/>
        <property type="gene ID" value="B6264_26190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34727">
        <property type="protein sequence ID" value="OEV34727"/>
        <property type="gene ID" value="HS99_0009585"/>
    </dbReference>
    <dbReference type="OMA" id="DMGSASY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21187" checksum="948B5EDAEE916C08" modified="2017-01-18" version="1">MHLTELPYRTLAIVRGSNRDAALRTVLVLAEEGITAAEVSLTTPDALWVIEQARRELGPHATLGAGTVLTGEDAARAADAGASFLVTPGFSEDLRRRTSELPWLIGALTPSEVISANENGALAVKLFPASLGGPGYLRALRDPFPGVPFIPVGGVDAALALTYLAAGAVAVGVGSPLIGDAASGGDLNALRGRAAGWRTALTEEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I1</accession>
    <name>A0A1E7N2I1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0009160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4241"/>
    <dbReference type="EnsemblBacteria" id="OEV34875">
        <property type="protein sequence ID" value="OEV34875"/>
        <property type="gene ID" value="HS99_0009160"/>
    </dbReference>
    <dbReference type="OMA" id="MAGSFRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12354" checksum="BE3BDCACD7CECF76" modified="2017-01-18" version="1">MSTGETVVCRLAGEIDQVQRPKLENALARAVNQRPHQLIVDMAAVSFCDSSGPNALLQTLQDAALTGTLLVLTALPPQVRRLLEVTGTDEVFTIRDSVYAALHGDRPHRRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N2</accession>
    <name>A0A1E7N2N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288638.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5895"/>
    <dbReference type="EnsemblBacteria" id="ARF82062">
        <property type="protein sequence ID" value="ARF82062"/>
        <property type="gene ID" value="B6264_27105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34936">
        <property type="protein sequence ID" value="OEV34936"/>
        <property type="gene ID" value="HS99_0035090"/>
    </dbReference>
    <dbReference type="OMA" id="HSMAWEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26775" checksum="D11926884ABC5E52" modified="2017-01-18" version="1">MREAPVTANGDRIRWVELPGAGPARLYLHGLGASSPVYFAAAVAHPLLTGRRSLLLDLLGFGISDRPTDFSYTLEAHADAVAAAVAAAGLRQVEVVGHSMGGAIAIVLAHRHPGLVSRLLLVDANLDPIESGRRRIGSSGIASYTEAEFLAGGRAEVADRVGAFWWSTMRLAGPEGLYRSAVHLARGSEPTMRELLLGLDLPRTFLHPEAEEPAGADELRAAGVRVVEVPDCGHNIMLDNPDAFAAAAAKALGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z5</accession>
    <name>A0A1E7N2Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284763.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4740"/>
    <dbReference type="EnsemblBacteria" id="OEV35068">
        <property type="protein sequence ID" value="OEV35068"/>
        <property type="gene ID" value="HS99_0034580"/>
    </dbReference>
    <dbReference type="OMA" id="RGLGGTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="47"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="415" mass="44286" checksum="88E5F83521FFC7E5" modified="2017-01-18" version="1">MPMPTPVSTPTPARLDVARQLLDLLADTRTEPRPDDQLEALTLAVAADLPVLLWGEPGIGKTAALNQLAEALDLPLTTVIASVHEPSDFSGLPVVGDDPAQQGVPLAPPDWAVRLVRAGRGLLFLDELSTAPPAVQAALLRLVLERRIGALQLPPGVRIVAAANPRSSAADGWELSPPLANRFVHLQWVHDHEVVVRGLGGVWPVAPLPRLDPGELSAAVVFARRAVCELLTVRPELVHRLPTNETKRGGAWPSPRSWDMTLRLIAFATAAGSSREVLSLLVRGTVGDGPGLELMASLDRMDLPDPEQLLADPACAVLPERGDLRQVVLDGVVAAVRSRPERARWDAAWAVLVRALETGAPDLLVVPATTLASLRREGWEVPAAIEHLASTVALSRRADRAAVRVAARTDVTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N382</accession>
    <name>A0A1E7N382_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0033625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285357.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000301.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4425"/>
    <dbReference type="EnsemblBacteria" id="ARF78466">
        <property type="protein sequence ID" value="ARF78466"/>
        <property type="gene ID" value="B6264_05630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35132">
        <property type="protein sequence ID" value="OEV35132"/>
        <property type="gene ID" value="HS99_0033625"/>
    </dbReference>
    <dbReference type="OMA" id="CNDFGGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22580" checksum="9C937F14491B3504" modified="2017-01-18" version="1">MASNGSDAPPTGRTPLRATADNALKIVVVGGFGVGKTTLVGSVSEIRPLNTEEVMTRAGEGIDPAGSWGKRSTTVAFDFGRITLSERQVLYLFGAPGQERFWFLWDRLFSGALGAVVLVDTRRLEDSWYAIDRLEHHGTPFIVARNNFGEPGHTLEQVREALDLPPEVPLVDCDARDRESGKRVLIELVHHLAALAGAPLTYEESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H2</accession>
    <name>A0A1E7N3H2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289489.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000681.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6148"/>
    <dbReference type="EnsemblBacteria" id="ARF79293">
        <property type="protein sequence ID" value="ARF79293"/>
        <property type="gene ID" value="B6264_10530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35230">
        <property type="protein sequence ID" value="OEV35230"/>
        <property type="gene ID" value="HS99_0033495"/>
    </dbReference>
    <dbReference type="OMA" id="NAHRAWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18942" checksum="71E131841B72C20E" modified="2017-01-18" version="1">MGAQKTARDDEFRAFAGSAWSRLLRTAYLLAGDRHGAEDLVQQALERAYVHWTKVRAADDPNAYVRRILVNEHARRFRRRPAEYLVEAFPDRPAPTGPDPDARAVLLAALAALPPRQREAVVLRYWEDLSESQTAAAMGCSVGTVKSQAARGLAKLRETSSLSELTTVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3M3</accession>
    <name>A0A1E7N3M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550020.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5326"/>
    <dbReference type="EnsemblBacteria" id="OEV35309">
        <property type="protein sequence ID" value="OEV35309"/>
        <property type="gene ID" value="HS99_0033165"/>
    </dbReference>
    <dbReference type="OMA" id="AWTVCWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="315"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="41414" checksum="465289014C77E154" modified="2017-01-18" version="1">MTGVAELSGTDQVVVVGAGLAGAQCALELRQGGWRGRIAVVGEEPHAPYDRPPLSKDVLLGKADATTLDIDYEGLGIELLTGRRATGLTPGVLHTDGGDLPYDSLVIATGATPRVLPGAERAHLLHTLDDALALRALLRPGLRLVLVGAGWIGAEVATAARQAGCEVTVVEAGPAPLPGALPTEIGSAMAAWYAEAGVELRCGVGVAAVEPGAVLLADGSHLPADEVVVGIGARPATGWLAGSGVELDASGAVLVDGRLRTTLPGVFAAGDCVSYPSARSGARLAVQHWDHALQSGGAAAAAVLGADEPYDPVPYFWSEQFGRMVQYAGRHAEGDELLWRGSPQDAGWSVLWLRDGVPGALLAVDRPRDLTQGRKLIERGAALDRALAADPSVALKSALRGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R1</accession>
    <name>A0A1E7N3R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0034090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene408"/>
    <dbReference type="EnsemblBacteria" id="ARF78895">
        <property type="protein sequence ID" value="ARF78895"/>
        <property type="gene ID" value="B6264_08180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35093">
        <property type="protein sequence ID" value="OEV35093"/>
        <property type="gene ID" value="HS99_0034090"/>
    </dbReference>
    <dbReference type="OMA" id="AGMTMLN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="729" mass="74697" checksum="36F301CA91DECC64" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T5</accession>
    <name>A0A1E7N3T5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278711.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2428"/>
    <dbReference type="EnsemblBacteria" id="OEV35350">
        <property type="protein sequence ID" value="OEV35350"/>
        <property type="gene ID" value="HS99_0032555"/>
    </dbReference>
    <dbReference type="OMA" id="RMIEAAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="22058" checksum="81E447D0E51C3694" modified="2017-01-18" version="1">MTAPPGRRERKKAATRQKIADTALRLFLERGYEAVGIRDVAAEADVAVTTLFSHFASKEALVFERDDDFEQRLTRAVTGRAPDQPLIPALRREIEALVRHCTADGAAPIWRMIDESPALREYEESMRLRHAESLAAAIAADPELSPTTTASRTIARFVIDAYSLAREAADPDAALDEIFGMIEAAWAVTRPSGEPDGRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Z0</accession>
    <name>A0A1E7N3Z0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2392"/>
    <dbReference type="EnsemblBacteria" id="OEV35408">
        <property type="protein sequence ID" value="OEV35408"/>
        <property type="gene ID" value="HS99_0032735"/>
    </dbReference>
    <dbReference type="OMA" id="YCPKEEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="173"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="572" mass="62223" checksum="8EB80707DD1DD546" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N439</accession>
    <name>A0A1E7N439_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289472.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1361"/>
    <dbReference type="EnsemblBacteria" id="ARF79284">
        <property type="protein sequence ID" value="ARF79284"/>
        <property type="gene ID" value="B6264_10465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35223">
        <property type="protein sequence ID" value="OEV35223"/>
        <property type="gene ID" value="HS99_0033430"/>
    </dbReference>
    <dbReference type="OMA" id="GEWYAGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12941" checksum="8DA9B6AC0E389997" modified="2017-01-18" version="1">MTREEFETLVGDALDRIPPHLAAMMDNVAVFVEDEPDPSDPELLGLYEGTPLTERGEWYAGVLPDRILIYRGPTLRHCETREQVVEEVRTTVIHEVAHHFGFDDHELDELGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4I4</accession>
    <name>A0A1E7N4I4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03085 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280449.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5395"/>
    <dbReference type="EnsemblBacteria" id="ARF80792">
        <property type="protein sequence ID" value="ARF80792"/>
        <property type="gene ID" value="B6264_19450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35599">
        <property type="protein sequence ID" value="OEV35599"/>
        <property type="gene ID" value="HS99_0006680"/>
    </dbReference>
    <dbReference type="OMA" id="GEMFIHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="22906" checksum="54F9DF7B6575A984" modified="2017-01-18" version="1">MSNHALAERHRLAELLTAAGPDAPTLCAGWTTRDLAAHLVIRERRADAAPGIRIGALAGWTRRVQDGYAERPYEDLVRLFRAGPPVYSLFALPGADEAANTVEYFVHAEDVARAGDDWTARPVPPGRSEALWRRLPLLARFEAGRHSPVRLTLARPDGRSLTVGPAGAPTVHLTGEPAELVLFAYGRGARTTLTVDGPPDAVEALRHVLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N542</accession>
    <name>A0A1E7N542_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0008065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550960.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene715"/>
    <dbReference type="EnsemblBacteria" id="ARF81026">
        <property type="protein sequence ID" value="ARF81026"/>
        <property type="gene ID" value="B6264_20840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35816">
        <property type="protein sequence ID" value="OEV35816"/>
        <property type="gene ID" value="HS99_0008065"/>
    </dbReference>
    <dbReference type="OMA" id="CAEPNLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="36618" checksum="15CF945F70A0A449" modified="2017-01-18" version="1">MQSEPQAVLSPLTGAAIFLVLTVEPGGEDAVRDLLPDLAGLRRSVGFRAPDGGLTCVTGIGSELWDRLFDGPRPADLRPFQELAGPRHRAPATPGDLLLHLRAERMDLCFELAGQLTTRLAGAATVADAVHGFRYFDDRDLLGFVDGTENPEGRAAAEATLVGAEDADFAGGSYVIVQKYLHDLDKWNALSVEQQEGAVGRTKLTDIELDDEAKPADSHVALTVITGPDGVEQKIVRYNMAFGSFDGGGEFGTYFIGYARDPGVTEEMLRNMFLGNPPGTTDRLLDFSTAVTGSLFYVPTADFLDSPPPPASRAADAVPADVAAAVPATEDRSDGSLGIGSLKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N578</accession>
    <name>A0A1E7N578_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063736263.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene728"/>
    <dbReference type="EnsemblBacteria" id="ARF81014">
        <property type="protein sequence ID" value="ARF81014"/>
        <property type="gene ID" value="B6264_20780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35804">
        <property type="protein sequence ID" value="OEV35804"/>
        <property type="gene ID" value="HS99_0008005"/>
    </dbReference>
    <dbReference type="OMA" id="TSANTWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16172" checksum="1B9AB93985425186" modified="2017-01-18" version="1">MHARTERLADSKYLLLTTFGDDGSRQDSQLWVVPDGTALGVWTPAHSGEAERIRRHPRVLIGPCDAHGRPTGRRLPARARLCDADATARYRTSLINKYGLTALIALARSRFRVGLDGTVGIRITLNELEQRLVGPEWLPPATYCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5W6</accession>
    <name>A0A1E7N5W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4951"/>
    <dbReference type="EnsemblBacteria" id="OEV36075">
        <property type="protein sequence ID" value="OEV36075"/>
        <property type="gene ID" value="HS99_0030875"/>
    </dbReference>
    <dbReference type="OMA" id="APLHAGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198794" evidence="1">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="530" mass="54390" checksum="5820EB4E9FD006A4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N690</accession>
    <name>A0A1E7N690_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386368.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36217">
        <property type="protein sequence ID" value="OEV36217"/>
        <property type="gene ID" value="HS99_0030720"/>
    </dbReference>
    <dbReference type="OMA" id="HFHFANK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21422" checksum="13B0041C885B7928" modified="2017-01-18" version="1">MVKQERAGRTRQAVLLAAADAFAQVGFEAASLVDISRRAGVSKGALYFHFVSKQALADGVRAAAGREIGSAALHALRAEGQAVQGLIDFSHELARLLREDVVVRAGVRLGRQGPRPGGGTCGPDTAWRSLTAVVHRLLDRADRAGELRPGADRHACAELLTAVVAGQVLLAADQAGRPAPEAVRRLWAAALPALVGPEGCAGYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6A0</accession>
    <name>A0A1E7N6A0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8053"/>
    <dbReference type="EnsemblBacteria" id="ARF79832">
        <property type="protein sequence ID" value="ARF79832"/>
        <property type="gene ID" value="B6264_13790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36220">
        <property type="protein sequence ID" value="OEV36220"/>
        <property type="gene ID" value="HS99_0030735"/>
    </dbReference>
    <dbReference type="OMA" id="PQNNREN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="533" mass="57873" checksum="1EBA2991FAB1A975" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F8</accession>
    <name>A0A1E7N6F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284219.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000574.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8039"/>
    <dbReference type="EnsemblBacteria" id="ARF79846">
        <property type="protein sequence ID" value="ARF79846"/>
        <property type="gene ID" value="B6264_13860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36234">
        <property type="protein sequence ID" value="OEV36234"/>
        <property type="gene ID" value="HS99_0030805"/>
    </dbReference>
    <dbReference type="OMA" id="QTQHLGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="33409" checksum="1021C41F1424F8B6" modified="2017-01-18" version="1">MALVGLEELRAARQRIAGVAVRTPLVPAPWAAEGERRLWLKPENLQPTGAFKTRGAYNRLSALSADERSSGVVAQSSGNHAQAVAYAAQLLGIKAVIVMPDTSPAVKVEATRSYGAEVILVPPAERDTLPGELADRHGYVWVPPYDDPFIIAGQGTVGLEIAEDAPAELDTVLVPVSGGGLIGGTAAALKLTRPGVRVIGVEPELAADARASLRSGRRVEWPAADTYRTIADGLRTPSVGVLPYEHITAYVDDIVTVTEDEIRATVALLARRGRLVAEPSGAVAPAAYFHRAAETGGQTVAAVVSGGNIDPGLLAELLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M4</accession>
    <name>A0A1E7N6M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82382">
        <property type="protein sequence ID" value="ARF82382"/>
        <property type="gene ID" value="B6264_29035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36328">
        <property type="protein sequence ID" value="OEV36328"/>
        <property type="gene ID" value="HS99_0029625"/>
    </dbReference>
    <dbReference type="OMA" id="PCAVTVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15027" checksum="9F945396A66CCCDB" modified="2017-01-18" version="1">MCHYGHTGTMDCDDEVMLTVRIAAAERALLRDLARGQGGDVSGVAVDGLLEVIPALHDDGSVLPLLRVLARPAPCAVTLWLPSEVADLLPLLGERLVHTGGSALGPASAALSAALRLWLAGDRAVLAAGLARLHGGCRVARMPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P2</accession>
    <name>A0A1E7N6P2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin acylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2658"/>
    <dbReference type="EnsemblBacteria" id="OEV36314">
        <property type="protein sequence ID" value="OEV36314"/>
        <property type="gene ID" value="HS99_0030100"/>
    </dbReference>
    <dbReference type="OMA" id="FNDASFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043147">
        <property type="entry name" value="Penicillin_amidase_A-knob"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023343">
        <property type="entry name" value="Penicillin_amidase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002692">
        <property type="entry name" value="S45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34218">
        <property type="entry name" value="PTHR34218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01804">
        <property type="entry name" value="Penicil_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198817" evidence="2">
        <location>
            <begin position="23"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="916" mass="96422" checksum="A418AD1F4446B6D8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P6</accession>
    <name>A0A1E7N6P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557556.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7163"/>
    <dbReference type="EnsemblBacteria" id="ARF82360">
        <property type="protein sequence ID" value="ARF82360"/>
        <property type="gene ID" value="B6264_28900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36349">
        <property type="protein sequence ID" value="OEV36349"/>
        <property type="gene ID" value="HS99_0029755"/>
    </dbReference>
    <dbReference type="OMA" id="SGAYDHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="520" mass="55069" checksum="D287363F12882A83" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C9</accession>
    <name>A0A1E7N7C9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000727.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7763"/>
    <dbReference type="EnsemblBacteria" id="ARF82305">
        <property type="protein sequence ID" value="ARF82305"/>
        <property type="gene ID" value="B6264_28585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36612">
        <property type="protein sequence ID" value="OEV36612"/>
        <property type="gene ID" value="HS99_0027930"/>
    </dbReference>
    <dbReference type="OMA" id="RPFVNAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="510" mass="55918" checksum="93C6DE83203FEDEE" modified="2017-01-18" version="1">MFDTSFAFPRALLNPVAGARGRVAVIGAGIAGLVCAYELERRGFDVVVHERSNRPGGRVRTHRFWDGTHVDLGAMRIPGNHHCVLHYVSQFHLETRPFVNANPRAYYHLRGQRVRVQDVAVLYPAYALRPGERQAPTPVLDRLLGPVWRSLTVEQQEHTLAGHWDDPALERAASVSLWQFVHEHLSQDAWDLIGHASGLAHYEQSSLLEVLVDYFGLFHEGQVELVDGLEALVHAFVRALRPGTLRLSSRIDELTLTTDGVRIHGKRLGAPLEDHADYVVCCVPAPALDQIAVSPGLPHSQRHAVRGISYASSSKTVLHLTRRRWELEDGIHGGGSFTDLPIQQCWYPSDNAMPVTDGVNGSADHRWAARDPLRSAEPTALLGAYQWGANARRFAALPPADRDALVLDCLERLHPGISADVDDILHCDWDVQTGMGGGAFAHLTPGEHTRYLTVLGSPHPADDPRIFFAGEHLSGAHAWCQGAARSALDAVAAVLDRAGHPRIATRVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U0</accession>
    <name>A0A1E7N7U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284695.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000482.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4775"/>
    <dbReference type="EnsemblBacteria" id="OEV36751">
        <property type="protein sequence ID" value="OEV36751"/>
        <property type="gene ID" value="HS99_0027435"/>
    </dbReference>
    <dbReference type="OMA" id="TGMTKSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="21719" checksum="145A9549CD46C660" modified="2017-01-18" version="1">MADEEFENVLTTVGPRLRALRRERGTTLAKLAAATGISLSTLSRLESGQRKPTLELLLPLAREYRVPLDELVGAPATGDPRIHPRPVTRNGQTIVPLTRHLGGLHAYKHIVPPGRNTGPELDLKVHEGYEWLYVLSGRLRLVLGPHDLELTAGEAAEFDTRTPHAFGNAGSQPVEFLSLFGPQGERIHVRARPGTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X4</accession>
    <name>A0A1E7N7X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82424">
        <property type="protein sequence ID" value="ARF82424"/>
        <property type="gene ID" value="B6264_29290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36795">
        <property type="protein sequence ID" value="OEV36795"/>
        <property type="gene ID" value="HS99_0027720"/>
    </dbReference>
    <dbReference type="OMA" id="PRDDLYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12835" checksum="5F2A2E646A19037C" modified="2017-01-18" version="1">MSHHPPDDHRSPEQLVAAGVLRRHADGRPHPALNHSPIAYVSTALWAELAALAIAPSAAEATAAALLRALADRAVDAALAPGNESAPRDDLYVTDPAHIGPHRRAVWFQRSGPGGPVTAAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N820</accession>
    <name>A0A1E7N820_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ohr subfamily peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284587.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4833"/>
    <dbReference type="EnsemblBacteria" id="ARF82426">
        <property type="protein sequence ID" value="ARF82426"/>
        <property type="gene ID" value="B6264_29300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36794">
        <property type="protein sequence ID" value="OEV36794"/>
        <property type="gene ID" value="HS99_0027710"/>
    </dbReference>
    <dbReference type="OMA" id="YSACFDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="13860" checksum="BF40FCB811F112B2" modified="2017-01-18" version="1">MDALYTAVATANGREGRAVSSDGQLDLALAMPPALGGSGQGTNPEQLFAAGYAACFASALGLVGRQARVDTSEVSVTAEVSIGKDDAGFGLSVVLRVELPDALAGESGLQLVKQAHEVCPYSRATRGNIPVELVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N825</accession>
    <name>A0A1E7N825_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367095.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36829">
        <property type="protein sequence ID" value="OEV36829"/>
        <property type="gene ID" value="HS99_0027420"/>
    </dbReference>
    <dbReference type="OMA" id="QYGDENF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="100"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="388"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="52860" checksum="F26FB9B1BE47136A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N848</accession>
    <name>A0A1E7N848_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="11" type="ORF">HS99_0026710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282052.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6443"/>
    <dbReference type="EnsemblBacteria" id="ARF78693">
        <property type="protein sequence ID" value="ARF78693"/>
        <property type="gene ID" value="B6264_06975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36861">
        <property type="protein sequence ID" value="OEV36861"/>
        <property type="gene ID" value="HS99_0026710"/>
    </dbReference>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="524" mass="56158" checksum="37F7F4A04EFA8D3D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8B0</accession>
    <name>A0A1E7N8B0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0027080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287034.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6834"/>
    <dbReference type="EnsemblBacteria" id="OEV36927">
        <property type="protein sequence ID" value="OEV36927"/>
        <property type="gene ID" value="HS99_0027080"/>
    </dbReference>
    <dbReference type="OMA" id="VPTYFRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="118"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="34961" checksum="035149BBE98651FF" modified="2017-01-18" version="1">MTAPMTTAGNAPEAPASPSPAKTIEGRSLGRIAWTRFKRDKAAVAGGIVVILLILLALLAGPLESLFGLDPDQPNTDLLDADLGGLPLGDWGGMSADHPLGIDPLQGRDLLARVVDGSWVSLLVAFGATVLSNTLGTVLGVMAGYYGGWVDTVISRLMDVFLAFPLLLFAIAISASLQGGAFGLHGLPLHIMVLIFVIGFFNWPYMGRIVRGQTLSLREREFVHAARSLGARGPFILFKELLPNLVGPILVYSTLLIPTNILFEAGLSFLGVGIQPPQSSWGGMLADAKNYYQVDPQYMVVPGLAIFITVLAFNLLGDGLRDALDPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N4</accession>
    <name>A0A1E7N8N4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556168.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7463"/>
    <dbReference type="EnsemblBacteria" id="ARF83050">
        <property type="protein sequence ID" value="ARF83050"/>
        <property type="gene ID" value="B6264_24790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37039">
        <property type="protein sequence ID" value="OEV37039"/>
        <property type="gene ID" value="HS99_0004215"/>
    </dbReference>
    <dbReference type="OMA" id="HAPQAAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12324" checksum="365639EC9AF6ADD5" modified="2017-01-18" version="1">MPSVLVLGIDPHAVPGMDGAVIRAALDQELARFGAHAIDASMALIALDESAESTMITALSEREWDVVVIGGGIRKPEPLLPLFEQVVNLVRRHAPKASIAFNTSGGDSVEAAKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q4</accession>
    <name>A0A1E7N8Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556133.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7445"/>
    <dbReference type="EnsemblBacteria" id="ARF81670">
        <property type="protein sequence ID" value="ARF81670"/>
        <property type="gene ID" value="B6264_24680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37059">
        <property type="protein sequence ID" value="OEV37059"/>
        <property type="gene ID" value="HS99_0004320"/>
    </dbReference>
    <dbReference type="OMA" id="VWPRFEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="18002" checksum="08A15B26A41E0E02" modified="2017-01-18" version="1">MADDWQDDRIGSALKGTNPTVLRRLDAGFAVIGDVQFLPGYSVLLTDEPGVERLSDLSRGRRTAFLADMDRLGEAVERVCRRLDPEFRRVNLEILGNTDGFLHAHVWPRFEWEPPDLVRRPVWLYPAENWCDPASALGPEHGLLREAIGRELDVLSAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8V7</accession>
    <name>A0A1E7N8V7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555733.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6664"/>
    <dbReference type="EnsemblBacteria" id="ARF81613">
        <property type="protein sequence ID" value="ARF81613"/>
        <property type="gene ID" value="B6264_24310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37119">
        <property type="protein sequence ID" value="OEV37119"/>
        <property type="gene ID" value="HS99_0004685"/>
    </dbReference>
    <dbReference type="OMA" id="FYVSYFQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="35840" checksum="4C0BE22144FEA46E" modified="2017-01-18" version="1">MHQPAPSADLRHRTIEAPAGRLHLVEQGTGPLVLLVHGFPESWYSWRRQLPALATAGYRAVALDVRGYGRSSKPAATDAYRMLDLVEDNVALVRALGEEKAVIVGHDWGSGIAAASALLHPEVFRAVGLLSVPYAPPGGPRPTDVFAQMGGDQEFYVSYFQEPGRAEAEMEPDLRGWLAGFYAAMSADTMPTPGEPDPHFVARTGGRLRDRFPGGSLPAWLTEDDLDVYAGEFERTGMTGALNRYRNMDRDWEDLAPYGGAPIEQPSLFIGGALDASTTWMADAIDAYPATLPGLTSSHILDGCGHWIQQERPEEVNRLLTSWLDSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y3</accession>
    <name>A0A1E7N8Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556667.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81577">
        <property type="protein sequence ID" value="ARF81577"/>
        <property type="gene ID" value="B6264_24105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37157">
        <property type="protein sequence ID" value="OEV37157"/>
        <property type="gene ID" value="HS99_0004885"/>
    </dbReference>
    <dbReference type="OMA" id="LYDYFRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17306" checksum="A08BF5559BCE9495" modified="2017-01-18" version="1">MGVMTDYFRAADAAVVRRVLEAADGGSPLLGPQRALDGVEAKGLDPTVVLGQLVAAVRQVPWAVDLVGDTPVWPATPPPGRDGPEDEDDPWLTGPWVFELDAGTRDTLAAIPDEDIPAVAARWARAEELHGASAESLCPVVGDLAGLARRARVAGDLLYCWTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N969</accession>
    <name>A0A1E7N969_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0005390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481053.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1336"/>
    <dbReference type="EnsemblBacteria" id="OEV37237">
        <property type="protein sequence ID" value="OEV37237"/>
        <property type="gene ID" value="HS99_0005390"/>
    </dbReference>
    <dbReference type="OMA" id="TIQHADH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="586" mass="62338" checksum="7CE68767C4D44EB1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N998</accession>
    <name>A0A1E7N998_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0005535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555181.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1307"/>
    <dbReference type="EnsemblBacteria" id="OEV37261">
        <property type="protein sequence ID" value="OEV37261"/>
        <property type="gene ID" value="HS99_0005535"/>
    </dbReference>
    <dbReference type="OMA" id="ARCIAHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198906" description="Phospholipase C" evidence="6">
        <location>
            <begin position="36"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30114" checksum="4A318DC14C975F31" modified="2017-01-18" version="1">MPFPTARSRTTLVLAAAVAGATTAAALTAGTSASAAATLPSPDHIVVVMLENHAYGQIIGSSDAPFLNSLATGGALLKASYGITHPSQPNYFAVFSGSTQGITDDSCYSPGFSKAPNLASELSAAGKSWGSYSEALPSQGSTTCSSGNYARKHAPWVGFGNIPGSTEHTFAQFPSDYGTLPKVSFVIPDLCGDMHNCSVGTGDSWLKNKLGGYASWARSHNSLLVVTYDEDDRNSGNHIPTLIYGQPARAGATSSTSYNHYDLLHTLEDLAGTGAHAGKSTSATDITGVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H9</accession>
    <name>A0A1E7N9H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556488.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5454"/>
    <dbReference type="EnsemblBacteria" id="OEV37339">
        <property type="protein sequence ID" value="OEV37339"/>
        <property type="gene ID" value="HS99_0006020"/>
    </dbReference>
    <dbReference type="OMA" id="YGTDWSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28909" checksum="5947ECA8CC96FCE8" modified="2017-01-18" version="1">MKTWFITGASRGFGRIWAEAALDRGDRVAATARDPETLRPLLDAHGDAVLPLRLDVTDRTGVTAAVRSAAETFGRLDVVVNNAGYGLFGMVEETTEEQARAQLDTNLFGPLWVTQAALPYLRAQGSGHILQVSSLGGLAAFPTLGLYNASKWALEGMSEALAQEVAPFGIHVTLVEPGPYGTDWSGASAVHTEPLPAYEPVRAARRAGASARTPQDARDTAAVVLELVDTDAPPLRLFLGTYPYPVVEAAYRKRLDTWNDWRHLASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M7</accession>
    <name>A0A1E7N9M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556608.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000238.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6193"/>
    <dbReference type="EnsemblBacteria" id="ARF81552">
        <property type="protein sequence ID" value="ARF81552"/>
        <property type="gene ID" value="B6264_23925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37183">
        <property type="protein sequence ID" value="OEV37183"/>
        <property type="gene ID" value="HS99_0005055"/>
    </dbReference>
    <dbReference type="OMA" id="KLCDAAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="196" mass="20736" checksum="92C6D65675843667" modified="2017-01-18" version="1">MTTKPSALRADARRNRERILEVAVRAFAEKGPNVAIDAIAKAAGVGSATLYRHFPTREALVEAAYRNELARVCDSAGKLLAGHAPDRALRLWMDDFIDYVAAKQGMADALRAAVASGADPFAETLDRLGAALGTLLRTGAEAGLLRPDVDPLDVGFSLAGVALITSAPDQRERAGRLLDLLLDGLRYGADRPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P6</accession>
    <name>A0A1E7N9P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385396.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7474"/>
    <dbReference type="EnsemblBacteria" id="OEV37415">
        <property type="protein sequence ID" value="OEV37415"/>
        <property type="gene ID" value="HS99_0004150"/>
    </dbReference>
    <dbReference type="OMA" id="MARRIQM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37621" checksum="5FA4E1F07FFA3E87" modified="2017-01-18" version="1">MAEDVILGVDTHKDIHVAAVITTLGASLAHQEFPTTAVGYRQLISWAKSFGIVRRAGIECTGSYGVALTRALRREHIDVIEINQPDRATRRKRGKTDAIDADAAARAVLSGRATTIPKTADGPAADLRVLRLAKESAVKARTQAMNQLKAVLLAVEPDLRELLTGLTNPALVATCVALGEDRGEAVFTMRLLARRIQNLGQEIKELTRRMTAAVRSSRPQLLDLVGVGPDSAAVLLSAAGDNPDRLTDEASFAALCGVSPVEQSSGKTQRRRLNRGGHRQADAALYRIVQSRLRWDERTQAYLQRRTAEGMSRREIIRCLKRYVARELYRHIRPSASPVTPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Z6</accession>
    <name>A0A1E7N9Z6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnA</name>
        <name evidence="4" type="ORF">HS99_0026235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287186.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000571.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7990"/>
    <dbReference type="EnsemblBacteria" id="ARF79055">
        <property type="protein sequence ID" value="ARF79055"/>
        <property type="gene ID" value="B6264_09120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37517">
        <property type="protein sequence ID" value="OEV37517"/>
        <property type="gene ID" value="HS99_0026235"/>
    </dbReference>
    <dbReference type="OMA" id="WGLARTG"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="33143" checksum="4094B72437CA652A" modified="2017-01-18" version="1">MAAPDAQKREPDQPEENTPVRPRVGHIQFLNCVPLYWGLARTGNLLDLDLTKDTPEKLSDQLVGGSLDIGPITCVEYLRNADDLLVMPDIAVGSDGPVMSCLIVSKVPLADLDGRRVALGSTSRTSVRLARLLLEEREGVRPDYFSCPPDLSAMLAEADAAVLIGDPALRAYLGQAADLGLTVHDLGEMWKEWTGLPFVFAVWAVRREFAERRPELTAAVHRAFLESRDLSLVEAAKVAEQAARWEAFGADVLERYFSEALDFSLGERQLAGVAEFARRVAHDSGFAPDVAVRLLEPTALPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA22</accession>
    <name>A0A1E7NA22_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ORF">HS99_0026345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286547.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1163"/>
    <dbReference type="EnsemblBacteria" id="ARF79038">
        <property type="protein sequence ID" value="ARF79038"/>
        <property type="gene ID" value="B6264_09010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37532">
        <property type="protein sequence ID" value="OEV37532"/>
        <property type="gene ID" value="HS99_0026345"/>
    </dbReference>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="445" mass="48788" checksum="802C6CBB2674C274" modified="2017-01-18" version="1">MTSQPYETLHFFGQDPWWLVLLKAVFCFAFLVLTVLVAIVWERKVVAWMQLRIGPNRHGPWGLLQSLADGVKLALKEDLVVKGSDKVVYVLAPIVCAIPAFMAFAVIPFGPPGNEVSVFGTRTPLQLTDFPVALLYVLATASVGIYGIVLAGWSSGSTYPLLGGLRSSAQMISYEIAMGLSFAAVFIYSGSMSTSEIVAHQQPTWFAALLPVSFIVYIIAMVGETNRAPFDLPEAEGELVGGFNTEYSSLKFAMFMLAEYVNMVTVSAVASTLFLGGWRAPWPVSTFWEGANHGWWPMLWITLKIQLLLFFFIWLRGTLPRFRYDQFMKLGWKVLIPVSLVWLVLITSVRALRNEGYGFGQVVLYVGAPVGAVLLLALVRDALRKQPEEAAASEDGPAEAFDPMAGGYPVPPLPGQVLPPVPRRPSRAPKQLQDALNGADHSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA28</accession>
    <name>A0A1E7NA28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1154"/>
    <dbReference type="EnsemblBacteria" id="ARF79031">
        <property type="protein sequence ID" value="ARF79031"/>
        <property type="gene ID" value="B6264_08965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37539">
        <property type="protein sequence ID" value="OEV37539"/>
        <property type="gene ID" value="HS99_0026390"/>
    </dbReference>
    <dbReference type="OMA" id="GMPTRTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="665" mass="70368" checksum="3F5C045207A367DD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA92</accession>
    <name>A0A1E7NA92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene140"/>
    <dbReference type="EnsemblBacteria" id="ARF83054">
        <property type="protein sequence ID" value="ARF83054"/>
        <property type="gene ID" value="B6264_25100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37413">
        <property type="protein sequence ID" value="OEV37413"/>
        <property type="gene ID" value="HS99_0003915"/>
    </dbReference>
    <dbReference type="OMA" id="HSDEQHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="27068" checksum="E3B39DA6327A66DB" modified="2017-01-18" version="1">MTREQARLDWETGTIFRPIRTGNAFEETVERLLQAIKLGVFGPGDRLPAERDLAARLGVSRETLREALRTLQQADCVAPRRGRYGGTFVTYRMPEPDVADLRRAARDLGGALEDALTYRQVLEVGAAEAAARRPLSPEQRAHLEDRLTELDAAPAEQYRQLDSRFHLAIGELTGSPSLAAAIAEARMRLNDLLNAIPMLDRNIEHAAEQHRAMVRAILDGDGDAARRATEEHLAATASLLRGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN2</accession>
    <name>A0A1E7NAN2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558204.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000938.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7092"/>
    <dbReference type="EnsemblBacteria" id="ARF78113">
        <property type="protein sequence ID" value="ARF78113"/>
        <property type="gene ID" value="B6264_03545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37755">
        <property type="protein sequence ID" value="OEV37755"/>
        <property type="gene ID" value="HS99_0024465"/>
    </dbReference>
    <dbReference type="OMA" id="VEPMVKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="12910" checksum="D6B6AB45343156CB" modified="2017-01-18" version="1">MILHLAPLDDWLADPGRPYATASLLTDGFIHCSADEQTALAVANAFYADTPDPLMVLLIEEALVEPMVKWEAPHGAPPPGATPGVLFPHIYGRLNRTAVVGLEKVERGPDGSWSALIPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAX4</accession>
    <name>A0A1E7NAX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000254.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5991"/>
    <dbReference type="EnsemblBacteria" id="ARF78005">
        <property type="protein sequence ID" value="ARF78005"/>
        <property type="gene ID" value="B6264_02840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37856">
        <property type="protein sequence ID" value="OEV37856"/>
        <property type="gene ID" value="HS99_0025120"/>
    </dbReference>
    <dbReference type="OMA" id="SVDGGCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="34540" checksum="0BE3BCAF897982F9" modified="2017-01-18" version="1">MFRTPRPTLFRAAATVLVGAMALTLTACGSGSKGSTAAGSSGGTVKVGLITKTDTNPFFVKMKEGAQKAAQEDGVTLTTAAGKFDGDNAGQIAAIENMVASGVKGILITPSDSKAILPAIKKARDKGVLVIALDSPTDPQDGTDALFATDNKKAGELIGQYAKAAMAGKPAKIATLDLAPGVAVGQLRHDGFLAGFGVAAGDPSIVCSQDTGGDQAKGQTAMENCLQKAPDINLVYTINEPAALGAYTALKAKGREKDVLIVSVDGGCTGTQAVKDGKIAATSQQYPMLMAEKGVKAVADFAKTGTKASGYTDTGVTLISDTPQTGVDSKDTGFGLTNCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB75</accession>
    <name>A0A1E7NB75_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HS99_0023810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278252.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2118"/>
    <dbReference type="EnsemblBacteria" id="ARF79454">
        <property type="protein sequence ID" value="ARF79454"/>
        <property type="gene ID" value="B6264_11480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37904">
        <property type="protein sequence ID" value="OEV37904"/>
        <property type="gene ID" value="HS99_0023810"/>
    </dbReference>
    <dbReference type="OMA" id="ERYKNDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="302"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV37904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="41935" checksum="D6224D95ECB9DBC1" modified="2017-01-18" version="1">MTFGFLNPLYTAVSWIIVQFHSLYSHVFNPDGGWAWGLAIASMVVVIRICLIPLFVKQIKATRAMQAIQPKMKAIQERYKNDRQRQSEEMMKLYKEAGTNPFSSCLPIIVQAPFFTALYGVLSKVAKGQDIGVIHGSLLVSAGKAHIFGAPLSATFLGSPETSVKIVTAVMIVMMSLSQFVTQRQLMTKNVDLTVKTPFMQQQKMLMYVFPVMFAVMGINFPVGVLVYWLTTNVWSMGQQLVVIHNNPTPGSKAFQERQERLKKAGRLRADGTEIKGALWGMLPPSKAAIAEAASASAVIEESVRASRQQPRRQTKAQRQHGGATQAAEPGGDTPVEQPAEEAVAADPGTKPAAAKQTAGKPAGTKQGTRQQPKRGGQRPKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB92</accession>
    <name>A0A1E7NB92_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0024140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278333.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2051"/>
    <dbReference type="EnsemblBacteria" id="ARF79511">
        <property type="protein sequence ID" value="ARF79511"/>
        <property type="gene ID" value="B6264_11815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37957">
        <property type="protein sequence ID" value="OEV37957"/>
        <property type="gene ID" value="HS99_0024140"/>
    </dbReference>
    <dbReference type="OMA" id="WFRWEPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="29290" checksum="4220D620CE99E063" modified="2017-01-18" version="1">MTTAAPAPATVTGPQSTTAGRLLALGRAEATLLLRNRAALFTAVVLPVVLISTLHGLLKKQSEDNPGLDVHSLLVYGSVGMVLAFVVYYNLTAAYVGRRGELVLKRLRTGEARDLEILLGTAVPSLVLGLFMAALIGIGGSLGLHLAVPVNPVLMLVGLLMLLATMIALAALSSAFTKTVESAGITTLPVMLVMQFGSGLYFPLEVMPSQLADVCRLLPTTPAFQLIRVGWFGTDGSAAATDFLGSWGAAAPHLVTGAVWLGLAVWGAVRYFRWEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBB4</accession>
    <name>A0A1E7NBB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386398.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000348.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2030"/>
    <dbReference type="EnsemblBacteria" id="ARF79529">
        <property type="protein sequence ID" value="ARF79529"/>
        <property type="gene ID" value="B6264_11925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37975">
        <property type="protein sequence ID" value="OEV37975"/>
        <property type="gene ID" value="HS99_0024250"/>
    </dbReference>
    <dbReference type="OMA" id="APFYGCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="40181" checksum="746B86E09A0CD7A6" modified="2017-01-18" version="1">MSTSADVPPLTSPAAATSPAAATVPAVAAGAVGSAALPAASAVGSPLSRLDLAQLGPNWYAAVMGTAIVANGAAALPVRVPGLIGFGEAMWGLGAAALLVLAAARLVHLTRHREAARTQLLDNPATAVFYGCPPMALLAVGLGTLLLGSRVIGTGPAVALDAVLWGVGTLYGLAVAAGIPYLMITRHPVSALEANPTWLLPVVAPLVASACGPALVPHLPAGLPQQAMLYGCWALFGVGLLATLVLLPVVFTGLFHSKVPALALTPALFLVLGPLGQSVTAIHQLADAARPVLPALAPVMLPLAELYGVAVIGVAMLWLAVALTANLRARRAGMPFAMTWWAFTFPVGTCVTGASALAGHTRFGGFTGLAAVLYLLLGAAWLLAAGGTVAGLLRGRLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM6</accession>
    <name>A0A1E7NBM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386526.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000388.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5954"/>
    <dbReference type="EnsemblBacteria" id="ARF79685">
        <property type="protein sequence ID" value="ARF79685"/>
        <property type="gene ID" value="B6264_12920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38106">
        <property type="protein sequence ID" value="OEV38106"/>
        <property type="gene ID" value="HS99_0023180"/>
    </dbReference>
    <dbReference type="OMA" id="PEERMRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="33030" checksum="8D86DE1A7346B1B6" modified="2017-01-18" version="1">MCGCGPAGSISGVTELQILDLTKEYRGGKRAVDSFTLTLRPGVLGLLGANGAGKSSLMRILATVTRPTSGRVLWEGVDITRRPGPLRRAVGYLPQDFGVYPQLTAREFLAYLAAAKGLRRRSARARIEELLELVNLSDAAGQRLGAMSGGMRQRVGIAQALLNDPALLIVDEPTVGLDPEERLRFGSLLSGMGAERIVVLSTHIVPDVAATADRIAVMGGGRLLHHGSTEELLLSAEGSVWELTVPADQLPPLRSRFLLGGTTRTPQGVRARVLSRHAPAAGARPVPPRLEDAYLLLTADRSATEQVAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBQ4</accession>
    <name>A0A1E7NBQ4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="4" type="ORF">HS99_0023235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737816.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000540.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5943"/>
    <dbReference type="EnsemblBacteria" id="ARF79677">
        <property type="protein sequence ID" value="ARF79677"/>
        <property type="gene ID" value="B6264_12870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38115">
        <property type="protein sequence ID" value="OEV38115"/>
        <property type="gene ID" value="HS99_0023235"/>
    </dbReference>
    <dbReference type="OMA" id="LDRRWTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="540"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1139" mass="118872" checksum="A569E7B876867BEB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR9</accession>
    <name>A0A1E7NBR9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0023390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000895.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7142"/>
    <dbReference type="EnsemblBacteria" id="ARF79651">
        <property type="protein sequence ID" value="ARF79651"/>
        <property type="gene ID" value="B6264_12700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38139">
        <property type="protein sequence ID" value="OEV38139"/>
        <property type="gene ID" value="HS99_0023390"/>
    </dbReference>
    <dbReference type="OMA" id="MKLCGPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="21617" checksum="675BDCF86E29FCB6" modified="2017-01-18" version="1">MDGDFKDFADIPTTTLADVLGRAQVMDIGLRPLWSGMPRVAGPAFTVQCPPGDNLMLHAAIYRAEPGSVIVVESGDLDHALAGGNVCAVAQRRGVAAFVADGLIRDLGEVRELGFPVVARGVIPIPGAKKQLGTHGAPVRCGGVLVAAGDIVVADEEGVVVVPATERVTALEAARVKLAKESAETLDDWQAAHHARIEQSLAELGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC0</accession>
    <name>A0A1E7NCC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283975.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4140"/>
    <dbReference type="EnsemblBacteria" id="ARF80151">
        <property type="protein sequence ID" value="ARF80151"/>
        <property type="gene ID" value="B6264_15615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38325">
        <property type="protein sequence ID" value="OEV38325"/>
        <property type="gene ID" value="HS99_0022660"/>
    </dbReference>
    <dbReference type="OMA" id="CANCAAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6695" checksum="184524E8A2780551" modified="2017-01-18" version="1">MTCDHLVCANCNGRVSDGRCSVCRANRARLQEQQGPFAALSPAMLLALLAGLLAVALIARQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ2</accession>
    <name>A0A1E7NCQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554959.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000653.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3068"/>
    <dbReference type="EnsemblBacteria" id="ARF82124">
        <property type="protein sequence ID" value="ARF82124"/>
        <property type="gene ID" value="B6264_27510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38480">
        <property type="protein sequence ID" value="OEV38480"/>
        <property type="gene ID" value="HS99_0021535"/>
    </dbReference>
    <dbReference type="OMA" id="RGKLWGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="23994" checksum="791598304BF309D7" modified="2017-01-18" version="1">MARGKLWGYVASGARALGAFGGAGGAGGAERKGAAGTPGGLGPYPPVAMAGPRTLSRTELDQLRWTGRQAGCEPQARHVQVAEVVRRVLRGGGRAAAVTVRLAPGLPVVAGDARRMEAAVAGLVDHAIRRSPLGGRVLVRADIRRTGPTAPRTGVGRGTTAHRRERVEIRISDRGTYEPPEAREWLLTGVRPSEPVGPALHSLVLAAGGRLVVEPTPGGGLTVVLLLTVAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ6</accession>
    <name>A0A1E7NCZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348413.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene688"/>
    <dbReference type="EnsemblBacteria" id="ARF77579">
        <property type="protein sequence ID" value="ARF77579"/>
        <property type="gene ID" value="B6264_00360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38557">
        <property type="protein sequence ID" value="OEV38557"/>
        <property type="gene ID" value="HS99_0019945"/>
    </dbReference>
    <dbReference type="OMA" id="IMPLAYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="36553" checksum="03D36262906B6053" modified="2017-01-18" version="1">MVAIGSGTVTTARLSDIAAQAGVSEATVSRVLNGKANVSAATRQTVLAALDVLGYERPTRLRQRSAGLIGLITPELSNPIFPALAQVIEQVLSRHGFTPVLCTQTPGGSTEDELVEMLVDRGVAGIVFVSGLHADSTADHDRYARLAGRGVPFVLINGFSEKIDAPFISPDDRSAMWMAVQHLAELGHERIGLAVGQRRYVPVLRKIEGFTAAMREVLGLGQEEAEGLVHHTLFSVEGGHAAAGALLDKGCTAIVCGSDMMALGAIRAVRQRGLSVPHDVSVVGFDDSPLIAFTEPPLTTIRQPVEAMATAAVDALLEEVGGNAAQRGEFMFQPELVMRGSTGACAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND65</accession>
    <name>A0A1E7ND65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldedh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551484.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38594">
        <property type="protein sequence ID" value="OEV38594"/>
        <property type="gene ID" value="HS99_0020215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="8519" checksum="E5C15F49F6E56429" modified="2017-01-18" version="1">MRRRFLAALRGLRIPVAVLNPATERVLTTVPAGGAADVDAAVTAARRAAPGWAATTRFLQYKPLQYCPARARGCRTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC7</accession>
    <name>A0A1E7NDC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene681"/>
    <dbReference type="EnsemblBacteria" id="OEV38699">
        <property type="protein sequence ID" value="OEV38699"/>
        <property type="gene ID" value="HS99_0019980"/>
    </dbReference>
    <dbReference type="OMA" id="FCREVWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="4"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_MalT" evidence="2">
        <location>
            <begin position="610"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="973" mass="107113" checksum="10D59A51773B4B70" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT3</accession>
    <name>A0A1E7NDT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556362.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5142"/>
    <dbReference type="EnsemblBacteria" id="OEV38860">
        <property type="protein sequence ID" value="OEV38860"/>
        <property type="gene ID" value="HS99_0019550"/>
    </dbReference>
    <dbReference type="OMA" id="SLWLDTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1695" mass="189694" checksum="C3F68990937B580F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDW5</accession>
    <name>A0A1E7NDW5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GFO_IDH_MocA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556368.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5147"/>
    <dbReference type="EnsemblBacteria" id="ARF81269">
        <property type="protein sequence ID" value="ARF81269"/>
        <property type="gene ID" value="B6264_22310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38864">
        <property type="protein sequence ID" value="OEV38864"/>
        <property type="gene ID" value="HS99_0019575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="34473" checksum="1DC9D98AB6A19D0D" modified="2017-01-18" version="1">MTGPAHVDPVRVGLVGVGIIAETHLAVLAERDDVVMEFTVDSRPVEPVEFRGATPPHYSSLAQALEAHQPDLVVLATPTETHAELAVLALLRSTARVLVEKPLVHDLASLMELCELDGKVDVRGRVFTAHHFAFSPEVDWASELIGVNSGWGPITAVTSAFYDPYVLRGPEAFASYVSSWTDSGVNQLSMLTRFVDLTEITSARQTDGGASAWCTVDFRSYGEVGTARLRSSWLTGSSSKESSLVFGRSGVEVWIDHTAMTGFAARQGELLGSFGNDGRTARKIAHYRPLYASLLSGRPDPVLGFDAAATITAIHRAVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ9</accession>
    <name>A0A1E7NDZ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">HS99_0019085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7369"/>
    <dbReference type="EnsemblBacteria" id="ARF82992">
        <property type="protein sequence ID" value="ARF82992"/>
        <property type="gene ID" value="B6264_21820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38919">
        <property type="protein sequence ID" value="OEV38919"/>
        <property type="gene ID" value="HS99_0019085"/>
    </dbReference>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15382" checksum="AA9CC76725BDF373" modified="2017-01-18" version="1">MVLNGPNLGRLGSREPDVYGATSYTGLVERCTALGKEFGFEVEVHETNSEQQMVEWLHEAADGKVPVVINPGAFTHYSYAMRDAAAQRTAPLIEVHISNPYARETFRHTSVIAAVASGTIAGFGIGSYELALRALAEQLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE14</accession>
    <name>A0A1E7NE14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7328"/>
    <dbReference type="EnsemblBacteria" id="OEV38912">
        <property type="protein sequence ID" value="OEV38912"/>
        <property type="gene ID" value="HS99_0018885"/>
    </dbReference>
    <dbReference type="OMA" id="GMGTRWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="543" mass="59420" checksum="8A3422ED69BFC2EA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE96</accession>
    <name>A0A1E7NE96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737775.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83250">
        <property type="protein sequence ID" value="ARF83250"/>
        <property type="gene ID" value="B6264_30385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39020">
        <property type="protein sequence ID" value="OEV39020"/>
        <property type="gene ID" value="HS99_0018115"/>
    </dbReference>
    <dbReference type="OMA" id="MFTDMKE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30619" checksum="C1A1EB954356F620" modified="2017-01-18" version="1">MPSDTANPATVLIAAESIDLSPTEPQQDADAAVRTARHARDEEDLVLLLTALGLPSGENDLARLAPHLATQAGTAGRPDQTHGGTPVSDTLTTVEQADVLANLDPMTREVALSMRYRGDSPLKILAATGLTEDELQALAARNPQTETGDAGPEFGTAVDELLAWGAQHPQAKVQRAAEQARQALEKLTAQREADQAVAAYEAKVATLKAQLASAEQALRDAKAGKPTTSAPSTRAGAAAGSAELAQPADKTVRNTIRAWANLHGHPVADRGVIPQAVLRAWYDAHPDTLAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF8</accession>
    <name>A0A1E7NEF8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83312">
        <property type="protein sequence ID" value="ARF83312"/>
        <property type="gene ID" value="B6264_30770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39077">
        <property type="protein sequence ID" value="OEV39077"/>
        <property type="gene ID" value="HS99_0018480"/>
    </dbReference>
    <dbReference type="OMA" id="ADFGICF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="31739" checksum="35269C7AACC174FD" modified="2017-01-18" version="1">MLNLERLRVLHAVSTTGSVVGAAQLLHVTTSAISQQIARLEQEIGTNLTERQGRGIRLTEAGTLLAGQAADLLAQVERVMATMAQHRGAVTGSLTIAAFPTAARALLPLTLRALRSRYRDLMVSAREQEPYEAIPAVQRGLLDLAVVEDWTDEPLALPQGLDHRVLFEDTYDIALPADHRLAGLPVLSLADLGAEDWITSSKGQLCHDWLLRSLKTARIAHTASEHPTQIALVAAGLGVAIIPHLGRERTSAPVRFIPLADAPRRRVLAIWRSTSAARPAVGVVVNALMEACSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV1</accession>
    <name>A0A1E7NEV1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000770.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3552"/>
    <dbReference type="EnsemblBacteria" id="OEV39231">
        <property type="protein sequence ID" value="OEV39231"/>
        <property type="gene ID" value="HS99_0000445"/>
    </dbReference>
    <dbReference type="OMA" id="VHPWADV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="459" mass="49072" checksum="D2BD7FFEF00B3BF3" modified="2017-01-18" version="1">MTEQPDHLLPTTRRALLHRVAVAQAEGRTPSLVAGVVREGRLVWSGARSMIDGHAPDADVQYRIGSLTKTFVAVLVLRLRDEGLLDLADPLGRHLPGTPADDVTVAQLLAHSGGLAAETPAPWWERTDGALRPELGDLLEEESPLKHPAGRCHHYSNPGYALLGALVEKVRGEPWGEVLRREVLAPLGLDRTTLLPEHPHAGGFAVHPWADVMLPEPLTDTGLMAPAGQLWSTGADLARWAAFLAAGDDKVLSADTLAEMSRPAIGPADADWTSGYGLGLQLRRHEGRLLYGHTGSMPGFTAGLWVSAEDGLAAFALSNATSGANTPLLAAQLIGITAAHEPRLPAPWRPLTEVDQELLALTGPWYWGAAPNVLRLHADGVLELTPDAGGHRGSRFRPQPDGSWLGLDNYYAGETLRVVRHADGTVSHLDVGSFVYTREPYGPAGAVPGGFDPQGWQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ7</accession>
    <name>A0A1E7NEZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480290.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000464.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3535"/>
    <dbReference type="EnsemblBacteria" id="OEV39218">
        <property type="protein sequence ID" value="OEV39218"/>
        <property type="gene ID" value="HS99_0000360"/>
    </dbReference>
    <dbReference type="OMA" id="MTHARTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199069" evidence="2">
        <location>
            <begin position="47"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="53045" checksum="FF1D6CC4863B69CD" modified="2017-01-18" version="1">MTHARTTPTRTTSTRTTPTHRRLLRAACALGAAAALALTGTQAAQADPGRHRTPGTERVSVGLGQAQPDSASHAAGLSADGRYAAFTSTAANLVPGDTNGKSDVFVRDLRTGRTERVDTGPDGVQADGASFEAAISADGRYVAFSSSATNLVAGANLGSDDVYVHDRRTGETTLVSVGEEPGQPQKDKFSGHPSISRDGRYIAFQSNRSDLAPGTVTWQGANIYVHDLRTGENRLVSTGADGKEANGSSASPVISADGGTVAFISKATNIIAPDRPGALSPDAATRLGAESDQESDEQFVRDSLRSPGSPRSADRPQLLKPHLYPLYVRDLRSEETTLASPDGKNGWRGADYPSLSADGRYAVYSAWVQHGDNWPDHHFEVYVRDLAKGTETLVSAGLPGTTTTGDSLNGRMTADGRWTYFDSTAANLVPGDTNGAGDVFRRDLCSGRTERVSLAADGSQSAGASYDPYVDDRGTTVVFTSEDGTLVPGDTNQAPDVFALRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF31</accession>
    <name>A0A1E7NF31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550225.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000713.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3619"/>
    <dbReference type="EnsemblBacteria" id="OEV39282">
        <property type="protein sequence ID" value="OEV39282"/>
        <property type="gene ID" value="HS99_0000770"/>
    </dbReference>
    <dbReference type="OMA" id="NGPSRQK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="6">
        <location>
            <begin position="321"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="51346" checksum="929BCCE2E3898B78" modified="2017-01-18" version="1">MSARPGSPQVRHLGPARLTAGLDRFQRLDLAAHLRVHPPLPRLTRDDLLELAERIDLRGRGGAGFPFARKARAAVAAATRTGAAPVIVVNGSEGEPPSAKDRMLLARAPHLVLDGALLAAAAFGAEEIVVGVAAGSPGEASVPAALDERELPCPARTVCVPERFVSGESSALIRGANGLPVQPAAVKARAAEGGAGGVRRRPTLLSNAETWAQLAVAARLGPGPYAAVGTDAEPGTVLLTVNRPGADPLVVETPFGTPLGDVLDACRLRPGDGVLVGGYHGAWLDPASAVGAPLSRTGLAELGGTLGAGAIVALPAGTCPLGEVARVATWLAGESAGQCGPCRRGLPDAAEALGALAAGTGGQTALEDARRALGGAQGGGACSHPDGTARFVLSALDVFARDVEAHLFGPGCGRPVLDVLPLPPAQGAHLEVDWSRCTGHGLCAVLAPGLVRLGPHGYPASTTIPVAPWQEHGARRAVNQCPALALRMRHPERSTDRRRRRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI2</accession>
    <name>A0A1E7NFI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367026.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7543"/>
    <dbReference type="EnsemblBacteria" id="OEV39432">
        <property type="protein sequence ID" value="OEV39432"/>
        <property type="gene ID" value="HS99_0001655"/>
    </dbReference>
    <dbReference type="OMA" id="GSWPEDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="30510" checksum="97240B3ECB587D09" modified="2017-01-18" version="1">MHADTRPTLAVWKFASCDGCQLTLLDCEDELLGLADQVRISHFLEMSGAEDGREPATLNGIGPYDLSLVEGSVTTEEDVRRIHHIRRISRRLVTIGACATAGGVQALRNFADVEQFRATVYASPQYIATLATSTPISAHVPVDFELRGCPIDRRQLLEVITAFLAGRKPNIPDHSVCFECKRRGNTCVTVAHGTPCLGPVTHAGCGALCPTYGRGCYGCFGPVANPNLVAMVRQLRQDGMTGRDIVRIFRTFNAASPEYAPVAELATQEPPEDPHPPETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG06</accession>
    <name>A0A1E7NG06_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550301.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39602">
        <property type="protein sequence ID" value="OEV39602"/>
        <property type="gene ID" value="HS99_0002705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="7200" checksum="86BDBFC8925BB6B0" modified="2017-01-18" version="1">MVPVDAESAQLLATRPQFGIPAGPWAHLAVLAAEVSRDGGLFWWHDWEQSATSLRTVERALSEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG41</accession>
    <name>A0A1E7NG41_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CADG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2831"/>
    <dbReference type="EnsemblBacteria" id="OEV39681">
        <property type="protein sequence ID" value="OEV39681"/>
        <property type="gene ID" value="HS99_0003185"/>
    </dbReference>
    <dbReference type="OMA" id="YDWATAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199107" description="CADG domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="CADG" evidence="3">
        <location>
            <begin position="395"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="628" mass="63837" checksum="1A69DDB294DFDD94" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA0</accession>
    <name>A0A1E7NGA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2860"/>
    <dbReference type="EnsemblBacteria" id="OEV39707">
        <property type="protein sequence ID" value="OEV39707"/>
        <property type="gene ID" value="HS99_0003335"/>
    </dbReference>
    <dbReference type="OMA" id="TSESTWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="15710" checksum="690B9D203CE82FE7" modified="2017-01-18" version="1">MGLPLLAGHVLVRLTDGAPEVAGAVLDALETAFPTHTGRGRTRIGNVWDVPPTLTSESTWTVAEAGPEGTRTIPGPGPAVSTSQAFDVQSPAPPPGPPALTGEATAELLGAPEHVETMLRALSELCPVDEEGREEQGPQLAVRLRLGCAAPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA7</accession>
    <name>A0A1E7NGA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387084.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000659.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2899"/>
    <dbReference type="EnsemblBacteria" id="OEV39736">
        <property type="protein sequence ID" value="OEV39736"/>
        <property type="gene ID" value="HS99_0003520"/>
    </dbReference>
    <dbReference type="OMA" id="QIVIHEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="19151" checksum="897478779E188976" modified="2017-01-18" version="1">MVFPRGLRRRCEQRLSGLSLPAPFTVEGFRAALERERGRRIVMEPLPALGPDLPCGLWIALPSIDVVYYEERTSPAHQDLIKLHELGHVLCGHTGTLELSRLTALLPDLTPELIAQLMGAGRTSYHTAEEQEAEMIALLLADLVGATTDPGPVSDRLAASLLHPIRQPRWRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI0</accession>
    <name>A0A1E7NGI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3477"/>
    <dbReference type="EnsemblBacteria" id="OEV39782">
        <property type="protein sequence ID" value="OEV39782"/>
        <property type="gene ID" value="HS99_0000085"/>
    </dbReference>
    <dbReference type="OMA" id="ICLARTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9517" checksum="FF8454DA1804B6C2" modified="2017-01-18" version="1">MVRTPLTPWERERGERFGALLREARGERSMVEVAAVAGVSAETLRKIETGRAPTPSFFTIAALAFALDLSLDELAGACVLPEDGEALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK7</accession>
    <name>A0A1E7NGK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555647.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6771"/>
    <dbReference type="EnsemblBacteria" id="OEV39836">
        <property type="protein sequence ID" value="OEV39836"/>
        <property type="gene ID" value="HS99_0002250"/>
    </dbReference>
    <dbReference type="OMA" id="LWSAFKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18443" checksum="7E145A08788D21F0" modified="2017-01-18" version="1">MTETRSLEPEEWEFWDTWMRAQRLLTKELERGLQRDCDISKPEFSVLVTLWQAAGSEMRVGELSESLDWDKSRVSHQLTRMEKRGFVKRTQYGADGRRAGIGLTAQGRRAAQSAILVHGGNIRRHFLDSLTPEQASVIRAWSEQAVDRLESHRSETAGDGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM7</accession>
    <name>A0A1E7NGM7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000236.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2949"/>
    <dbReference type="EnsemblBacteria" id="OEV39775">
        <property type="protein sequence ID" value="OEV39775"/>
        <property type="gene ID" value="HS99_0003760"/>
    </dbReference>
    <dbReference type="OMA" id="GGTHIYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="34954" checksum="FF96F54DC88674F9" modified="2017-01-18" version="1">MKPFDYLAPADAAEAVRSVAANPDAVFLGGGTNLVDHLKLGVAEPGLVVGLAGLLPSGIEELDDGALRIGAGVSNSDLAADPRVRERFPVLSQALLSGASGQLRNMATVGGNPLQRTRCVYFQDVTTPCNKREPGSGCSAIGGWTRHHAVLGASEHCIAVHPSDMAVAMAALDARVRTLGPAGERAIPFVELHRLPGDAPERDTALEHGELITAIDLPAQPIARRSAYHKVRDRASYAFALVSVAAAIEVEGGVIRDARIAFGGVAHAPWRARRAEEALRGAPASDGSYRAAADAELTDARPAEGLDGGNAFKIPLLRRTLTATLRDLAGEDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGN6</accession>
    <name>A0A1E7NGN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385962.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39866">
        <property type="protein sequence ID" value="OEV39866"/>
        <property type="gene ID" value="HS99_0003410"/>
    </dbReference>
    <dbReference type="OMA" id="NIPAYGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="372" mass="39520" checksum="9BBA024CF7D50FBA" modified="2017-01-18" version="1">MLPLVEELVRRGHQVVYATEAAHAATVTGAGARWLELPSPPPFTPPSTFGPEAVAGWLRHYFAALSGTYPVLRRHCLSEPVDAVCYDTTNWPGRIAARSLGIPGVQCFPHLASNEKYSLDRQLTAGIDADGPEFVALAADCAAFSREYGVPLGVADTMTVADGLNLVFVPREFQPAADSFDERFHFVGPSLESRERSESWSPRDPDAPLLYVSLGTVVDGHADFYRACVAAVADRPWQVAVSVGGAPRSALGAVPGRVEVRSWFPQLAVLRRAAAFVSHAGMNSVMEALTYGVGIVAVPRTPEQAANAGRLAELGLGVRLDAEAAGAGELRAAIDRVASDPAVRAALAEMRRAIRRGGGAARGADLVEGYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV04</accession>
    <name>A0A1E7MV04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2963"/>
    <dbReference type="EnsemblBacteria" id="OEV32260">
        <property type="protein sequence ID" value="OEV32260"/>
        <property type="gene ID" value="HS99_0016205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16128" checksum="3AFFFA06BCC57CBE" modified="2017-01-18" version="1">MTGDGAARGPVVWAMAVREAVQGPPIAELIVEVGANLHADLFEAAVDSGFTVAAGEPPATTGVIEVGGGRVERLLLVGGRQGWEPGSRVEVSPRWLAAAEGRGEAVVVVVPPPDWPLGPVAEDLGTRVDAFTRWVEEQRVAGRVLHGAVSVRGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV44</accession>
    <name>A0A1E7MV44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553765.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6878"/>
    <dbReference type="EnsemblBacteria" id="OEV32301">
        <property type="protein sequence ID" value="OEV32301"/>
        <property type="gene ID" value="HS99_0016455"/>
    </dbReference>
    <dbReference type="OMA" id="RTEMDYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="117"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="374"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="557" mass="60011" checksum="026BCD1C4BADCFCC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV96</accession>
    <name>A0A1E7MV96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6933"/>
    <dbReference type="EnsemblBacteria" id="OEV32345">
        <property type="protein sequence ID" value="OEV32345"/>
        <property type="gene ID" value="HS99_0016725"/>
    </dbReference>
    <dbReference type="OMA" id="DHHVKEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18955" checksum="F97B23655B18D3B8" modified="2017-01-18" version="1">MSNDAIVLLREDHKEVRRLFREYQGLADGDDGARRRTVQRIVEELTVHTYLEDELVYPRIRQELPGLAEEMDRAEQEHHVADLLCEELHGMSPDDNGYDAKTAVLIDAVERHIEHEESEVFPKVRAALGRTELRELGERMQAVRETAPRQPTAGGVLHRIADALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVA7</accession>
    <name>A0A1E7MVA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553823.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6948"/>
    <dbReference type="EnsemblBacteria" id="OEV32358">
        <property type="protein sequence ID" value="OEV32358"/>
        <property type="gene ID" value="HS99_0016800"/>
    </dbReference>
    <dbReference type="OMA" id="FVVQIHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigD_N" evidence="2">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="23303" checksum="9BD9617ED7E31D71" modified="2017-01-18" version="1">MAAHDALDRYHRRRDFTRTAEPRGAEPGEPGDRPRFVVQIHDARTLHFDFRLEADGVLKSWAVPKGPSTDPHDKRLATPTEDHPLEYRTFEGVIPEGEYGAGAVIVWDEGTFRNLTTDRDGRPVPFAEALDRGHASFRLEGHKLHGGYALTRIRTDRDPARRGGGNREAWLLVKRADARASTQGTPDPYRARSARSGHTLRQVAAGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG0</accession>
    <name>A0A1E7MVG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32416">
        <property type="protein sequence ID" value="OEV32416"/>
        <property type="gene ID" value="HS99_0017145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="12189" checksum="20E9D9CA58ECD40F" modified="2017-01-18" version="1">MIEVYGTGAGACGFSSSPGVGLGGGAGRDRSESPGPVLAGGAARFTVRAGQRACAVIGLDCSGAITGTVQGVNEINVLVDQDGVSVPLAGIRSFPLPGGVRVLGPWMGLYRAGVAEAAACAATAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP7</accession>
    <name>A0A1E7MVP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000184.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6921"/>
    <dbReference type="EnsemblBacteria" id="OEV32333">
        <property type="protein sequence ID" value="OEV32333"/>
        <property type="gene ID" value="HS99_0016660"/>
    </dbReference>
    <dbReference type="OMA" id="IGGHMSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="194"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="31256" checksum="779F35EF9A841260" modified="2017-01-18" version="1">MDTSALHTHRWSRRLRRALEAPAHWEVLDTPAQPLADAFQSLPLGPYRDALHGVWLGHPLHPALVQLPIGCWTSAGLLDLAPGRRRSADVLVAAGLLAAGPAALAGWVDWSRLDAPRRRTGLVHALANTGGVLLYTGSLLARCRGHRGRGRLLGWAGMTAVAVGGVLGGHLAYRQAAGPDRAAAVPRLAPPDWATLGPVEDFPVGQPVRRRVGELAVVVVRDGERCHVLAERCAHLSGPLSEGSVVDGCLRCPWHGSKFRLRDGEVAGGPATAPQPVLETRVLSGHLEVRLPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVX9</accession>
    <name>A0A1E7MVX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289067.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78376">
        <property type="protein sequence ID" value="ARF78376"/>
        <property type="gene ID" value="B6264_05080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32586">
        <property type="protein sequence ID" value="OEV32586"/>
        <property type="gene ID" value="HS99_0015000"/>
    </dbReference>
    <dbReference type="OMA" id="EVTMRQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="33893" checksum="645A4235D09CECCF" modified="2017-01-18" version="1">MRTVGCLIFDGVRAFDYAVIGEVWANRATRPGVPAFDLRVCGPVGARVRLGGGLERVPDLGLAALAACDLVVVPGVEDPAARRPAEVLDALRAVSSAGVPVASLCAGAFVLAEAGLLDGREATTHWALAPELARRHPAVTVRPEVLFTGGDGVWTSAGVAAGIDLCLHLVRTAHGQQAAAAIARAMVTAPFRAGGQAQFIPSPVPPVDEDDPLARVRAEILAALDTPWTVRRMAAAALMSERTFARRFTATTGTTPLRWLLDQRILTVQRLLEETDLPVDTVATRCGFASAVSLRPVFVKRVGVAPREYRRTFRGREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW39</accession>
    <name>A0A1E7MW39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000156.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3864"/>
    <dbReference type="EnsemblBacteria" id="ARF78318">
        <property type="protein sequence ID" value="ARF78318"/>
        <property type="gene ID" value="B6264_04755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32640">
        <property type="protein sequence ID" value="OEV32640"/>
        <property type="gene ID" value="HS99_0015325"/>
    </dbReference>
    <dbReference type="OMA" id="IAGLCMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7591" checksum="CE969EBB42F40F97" modified="2017-01-18" version="1">MDKRNALRAGAVCATVTLMMLLSSPAMALTRDDGDDPGTGLSVGQTVGLYVLIPLAAFAIIAGLAALPYGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWB9</accession>
    <name>A0A1E7MWB9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78232">
        <property type="protein sequence ID" value="ARF78232"/>
        <property type="gene ID" value="B6264_04250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32728">
        <property type="protein sequence ID" value="OEV32728"/>
        <property type="gene ID" value="HS99_0015835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="9711" checksum="2527070E3C3D2146" modified="2017-01-18" version="1">MAAMVAMASETATPTDAAVATMPAAVAAAMAAEMLKVTMARAAPTTRVPPTIAASSSSFLIALSTSWTKSRSALARARQASAVSGSQPLPLPAASLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWN3</accession>
    <name>A0A1E7MWN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288228.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3141"/>
    <dbReference type="EnsemblBacteria" id="ARF78306">
        <property type="protein sequence ID" value="ARF78306"/>
        <property type="gene ID" value="B6264_04690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32653">
        <property type="protein sequence ID" value="OEV32653"/>
        <property type="gene ID" value="HS99_0015390"/>
    </dbReference>
    <dbReference type="OMA" id="CPECAGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="14469" checksum="210D9F78C5ED3F5E" modified="2017-01-18" version="1">MEPIVVSACLAGVPCRYDGRAKTADGAVRLVAEGRAVVVCPEGAGGLPTPRPAAEIVGGDGADVLDGRARVVDATGADCTAEFLSGARAALAAAQEAGARRAVLMARSPSCGCGQVYDGTFSGELRPGDGVTAALLRRSGIEVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWT5</accession>
    <name>A0A1E7MWT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287361.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene441"/>
    <dbReference type="EnsemblBacteria" id="ARF78868">
        <property type="protein sequence ID" value="ARF78868"/>
        <property type="gene ID" value="B6264_08010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32891">
        <property type="protein sequence ID" value="OEV32891"/>
        <property type="gene ID" value="HS99_0039650"/>
    </dbReference>
    <dbReference type="OMA" id="TMLDTMH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="91"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="547" mass="59146" checksum="05A08D51232F7E4E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW6</accession>
    <name>A0A1E7MWW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552568.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5782"/>
    <dbReference type="EnsemblBacteria" id="ARF81342">
        <property type="protein sequence ID" value="ARF81342"/>
        <property type="gene ID" value="B6264_22710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32932">
        <property type="protein sequence ID" value="OEV32932"/>
        <property type="gene ID" value="HS99_0013690"/>
    </dbReference>
    <dbReference type="OMA" id="WNQMRMS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="87"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="277"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="2">
        <location>
            <begin position="418"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="531" mass="56128" checksum="30851A1D8DE13462" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX23</accession>
    <name>A0A1E7MX23_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="8" type="ORF">HS99_0015575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386076.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3179"/>
    <dbReference type="EnsemblBacteria" id="ARF82622">
        <property type="protein sequence ID" value="ARF82622"/>
        <property type="gene ID" value="B6264_04510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32793">
        <property type="protein sequence ID" value="OEV32793"/>
        <property type="gene ID" value="HS99_0015575"/>
    </dbReference>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="25482" checksum="5B1E9BC49731893D" modified="2017-01-18" version="1">MAQAAAARLITRIVDAQAARGTASVVLTGGRNGNALLAAIAASPARDAVDWGRLDLWWGDERFVPAADGDRNAVQARAELLDAVPLDPARVHEMPASDGVDGSDVEAAAARYAQELARAAGPGDRLRVPAFDVLLLGVGPDTHVASLFPEHPGVRETELTVVGVRGAPKPPPTRISLTLPAIRAAREVWLLAAGEDKAGAVALALSGPGELQAPASGAYGRSRTLWLLDRAAAERIPAQLYPPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX52</accession>
    <name>A0A1E7MX52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine 5-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279857.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5691"/>
    <dbReference type="EnsemblBacteria" id="ARF81428">
        <property type="protein sequence ID" value="ARF81428"/>
        <property type="gene ID" value="B6264_23175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33010">
        <property type="protein sequence ID" value="OEV33010"/>
        <property type="gene ID" value="HS99_0014145"/>
    </dbReference>
    <dbReference type="OMA" id="TYDDVFM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="479" mass="50513" checksum="2DFCFA84C3CE5ECC" modified="2017-01-18" version="1">MRFLNDLKPSYDLTYDDVFMVPSRSAVGSRQGVDLSSNDGTGTTIPLVVANMTAIAGRRMAETVARRGGLVAIPQDIPTEVIADVISWVKRRHLVVDTAITLTPGATVAEALSLLHKRAHGALVVVEDDKPVGVVSESDCQGVDRFTGLADIMSRDLLVLDEDIDPRAAFDKLTEAHRKLAPVVDREGKLVGLLTRKGALRATLYTPAVDANGKLRIAATVGINGDVAGKAKALIEAGADVLVVDTAHGHQESMISALRAVRGLDPQIPIVAGNVVSAAGVRDLVEAGADILKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEARRLGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQTTADGRQYKESFGMASARAVSNRTAQDSSYDRARKALFEEGISHSRMFLDPARPGVEDLIDSIVAGVRSSCTYAGASSLEEFHEKAIVGIQSAAGYAEGKPLHSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX59</accession>
    <name>A0A1E7MX59_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0014095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385420.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5701"/>
    <dbReference type="EnsemblBacteria" id="OEV33001">
        <property type="protein sequence ID" value="OEV33001"/>
        <property type="gene ID" value="HS99_0014095"/>
    </dbReference>
    <dbReference type="OMA" id="ELFPYLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="27730" checksum="4F9CD16A5456C9EF" modified="2017-01-18" version="1">MQLNSSRGGTVSHIDPSRPAPVLQLSGVSRVHGHGAAEVHALRGVDLTVHAGEFVAVMGPSGSGKSTLLTLAGGLDLPSDGQVLVEGVALRGLSRGRLADLRRRSVGYVFQDYNLIPALTAAENIALPRELDGVSGRTARREALAALEELGIGELADRFPDDMSGGQQQRVAIARALIGERRLVLADEPTGALDSATGDAVLAVLRARCDAGAAAMMVTHEASHASWADRVVHLRDGAVASESVGRRSGGCRAAVHRPNSLDEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE6</accession>
    <name>A0A1E7MXE6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558010.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3426"/>
    <dbReference type="EnsemblBacteria" id="OEV33099">
        <property type="protein sequence ID" value="OEV33099"/>
        <property type="gene ID" value="HS99_0014680"/>
    </dbReference>
    <dbReference type="OMA" id="DWAREGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="45099" checksum="25354CB8CB0CA439" modified="2017-01-18" version="1">MSQRSGSPHEAPESGEDIREQAVRLVARLEPRINQLARLVVERQRAQVPGFDRLPDDLQDLEAASTARQAIRDFLRCTQGLADAEAEVFRERAAQRAAEGVPLIGLIKSYHVGAEVLTDALCAAARSGEDAALLWLVRRHFRAVNAMVEQVTEAYLLGAADQQAAGRELAAALIRGDAPQEVAARYGLPLEPGYLVLSVRSPTPQEPVAARRLLHQVLGRLAPTAAGRALSLPDEQGGHILLPLGTPHADLVRHLSTGLPRPAIAGAALAATPQDVPAAAEQARRIAAIARTPGVHRLQDVLLDYHLAGSKDSAAELSALLDPLDRHAGLVETVAAFLDCDLDRRRTAQALNVHPNTVDNRLARAAQLTGLDPHTTHGVQHFGAALTLRRLAEGSATGRIPGSAVETNWPDGGQGMLPWGPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT3</accession>
    <name>A0A1E7MXT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron reverse transcriptase/maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558097.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000141.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33260">
        <property type="protein sequence ID" value="OEV33260"/>
        <property type="gene ID" value="HS99_0039025"/>
    </dbReference>
    <dbReference type="OMA" id="DQCFKCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="585" mass="66495" checksum="B22ED19349F8D273" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT8</accession>
    <name>A0A1E7MXT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554176.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene174"/>
    <dbReference type="EnsemblBacteria" id="OEV33246">
        <property type="protein sequence ID" value="OEV33246"/>
        <property type="gene ID" value="HS99_0038995"/>
    </dbReference>
    <dbReference type="OMA" id="MTAGTFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33321" checksum="1B93AEBA61A956DD" modified="2017-01-18" version="1">MDLRIFTEPQQGASYDTLLRVARTAEELGVFSAFFRSDHYLKMGDVDGLPGPTDAWITLAGLARDTSTIRLGTLMTAGTFRLPGVTAIQVAQVDAMSGGRVEFGLGAGWYEAEHTAYGIPFPKEKFGRLEEQLEIITGLWRTKLGDTFDFAGKYYTLTDSPALPKPVQERIPVLVGGLGPKRTPALAARFADEFNLPFASLDDTVAQFARVRAAVEQAGRSADDLVYSNALVLCVGRDDAEVARRAAAIGREVDELKENGLAGTPDEVVEKIGRYAAAGSQRVYLQVLDLGDLDHLELVASRVAPQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXV0</accession>
    <name>A0A1E7MXV0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554263.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene173"/>
    <dbReference type="EnsemblBacteria" id="OEV33256">
        <property type="protein sequence ID" value="OEV33256"/>
        <property type="gene ID" value="HS99_0039000"/>
    </dbReference>
    <dbReference type="OMA" id="ICWLVRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045647">
        <property type="entry name" value="DUF6401"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19939">
        <property type="entry name" value="DUF6401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10723" checksum="9951AA11EA031723" modified="2017-01-18" version="1">MPGIVAAFTPRLAEFAFEPGFVAAVDQHAAMLRELLYAQGPELAPRPLDREELSDYALGFLDALTEIGWREPVGYDYAVTRLTAICWLVREQGRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY29</accession>
    <name>A0A1E7MY29_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0012035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737962.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7032"/>
    <dbReference type="EnsemblBacteria" id="OEV33324">
        <property type="protein sequence ID" value="OEV33324"/>
        <property type="gene ID" value="HS99_0012035"/>
    </dbReference>
    <dbReference type="OMA" id="WRLDTPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="508"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="600" mass="62820" checksum="B68DF4A87B13CC94" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC6</accession>
    <name>A0A1E7MYC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366804.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6580"/>
    <dbReference type="EnsemblBacteria" id="ARF80549">
        <property type="protein sequence ID" value="ARF80549"/>
        <property type="gene ID" value="B6264_18005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33445">
        <property type="protein sequence ID" value="OEV33445"/>
        <property type="gene ID" value="HS99_0012780"/>
    </dbReference>
    <dbReference type="OMA" id="NYHRITR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="39438" checksum="E7D17EC5D5CD0F56" modified="2017-01-18" version="1">MISSPPKLREELEVIRGMDDIPLIFDPVTGNYHRITRASEVVLTYLDGTRTRDDLVDFFASHGRSGSEAFTRQLDSFLASLEKSGLLEGSQPPEKPGGNRVRTSMLMPRIVLTKSLPTVLEPVARLLRAAPARLLVSVAVLAALVGYATGFHTLFTATPSLQQLAGPAFLVATGVMLFLVLLHETAHALVAQMLRAPIRGLGVALLFYFMPVAYVDRTDAYRVRARSGRVVLALAGILSDGVFCGLTGVVATHSTGFVQHTATFVLGMQLLMLIVNLNPLMPSDGYTALEAASGRTNARGRAFALLRGILKRQPLPPHLENLTTRARAAYVVYGLFSVGYVCFLAFSMIRAVPVSIHLALSAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ38</accession>
    <name>A0A1E7MZ38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene437"/>
    <dbReference type="EnsemblBacteria" id="OEV33698">
        <property type="protein sequence ID" value="OEV33698"/>
        <property type="gene ID" value="HS99_0038290"/>
    </dbReference>
    <dbReference type="OMA" id="LYRREHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="810" mass="87191" checksum="7C9DBE772B3A4628" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB1</accession>
    <name>A0A1E7MZB1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ORF">HS99_0037780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3783"/>
    <dbReference type="EnsemblBacteria" id="OEV33790">
        <property type="protein sequence ID" value="OEV33790"/>
        <property type="gene ID" value="HS99_0037780"/>
    </dbReference>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="315"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="547" mass="60921" checksum="DF2C6F6B8CD31BDF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF0</accession>
    <name>A0A1E7MZF0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name evidence="2" type="ORF">HS99_0037455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289881.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000902.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4314"/>
    <dbReference type="EnsemblBacteria" id="ARF80331">
        <property type="protein sequence ID" value="ARF80331"/>
        <property type="gene ID" value="B6264_16715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33830">
        <property type="protein sequence ID" value="OEV33830"/>
        <property type="gene ID" value="HS99_0037455"/>
    </dbReference>
    <dbReference type="OMA" id="TEHRHYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19696" checksum="175A61D641A8AD27" modified="2017-01-18" version="1">MSTTHTDRLRALLEPLAAQAGLDLEDVKVTRAGNRRQVQIDVDTDGGVDMDTIAEFSRVVGEALDASDVMGDEPYLLEVGSPGAERPLVLPRHWQRAEGRLAKIHLVDGGEIVARVLEADEDGALVEVQPVKGRGRPKERRLEYAEVARARVQVEFNRKDDEQLLDEAADFDEGDDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP6</accession>
    <name>A0A1E7MZP6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="8" type="ORF">HS99_0010430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552220.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000744.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1824"/>
    <dbReference type="EnsemblBacteria" id="ARF77734">
        <property type="protein sequence ID" value="ARF77734"/>
        <property type="gene ID" value="B6264_01270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33891">
        <property type="protein sequence ID" value="OEV33891"/>
        <property type="gene ID" value="HS99_0010430"/>
    </dbReference>
    <dbReference type="OMA" id="TSGNHDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="42198" checksum="0B5F38674DB0E5A1" modified="2017-01-18" version="1">MRLLHTSDWHLGRSFHRESLHDAQRAFLDHLVAVVRSEGVDAVLVAGDVYDRALPGLDAVALFDDVLHRLADLGVPTVFISGNHDSARRLGVGAGLIGQAGIHLRTDPGECAEPVLLADRHGPVAVYGLPYLEPTLVRERFGLAKGGHAAVLGAAMDRVRADLAMRPEGTRAVVLAHAFVTGGAPSDSERDIAVGGVAAVPASVFDGVYYAALGHLHGCQTLAPHLRYSGSPLAYSFSEARQRKTMWLVDLAADGSVTAERVDCPQPRPLATLRGTLEALLTEEAYAEHEQSWVQVTLTDAARPSEPMEKLRRRFPHTLQLLFDPEDGGAEPSRSYAARVSGRDDLEIAEGFLRHVRPGAEPEPDELGWLREGFERVREGADRKADLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ1</accession>
    <name>A0A1E7MZQ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0010585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387176.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1855"/>
    <dbReference type="EnsemblBacteria" id="OEV33920">
        <property type="protein sequence ID" value="OEV33920"/>
        <property type="gene ID" value="HS99_0010585"/>
    </dbReference>
    <dbReference type="OMA" id="LDEARFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198591" evidence="8">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="31590" checksum="066B25EAE31A045F" modified="2017-01-18" version="1">MGALVLCAALSLALGSRSVPLATVVDALTGAAHGGDADVVTGLRVPRTLIGLAVGAALGVAGAVAQGVTRNPLASPITLGINAGASLAVVAAIYTLDLSRPAEYVWFAFAGAAVAAVAAYAMSRRGGDLDPVRLALGGTVLTVVLTSWTSALMLASHRTLDEARFWLAGSIAGRHLDTLTPVLPFLVLGLVAAFAISPALNALALGDETAQSLGVPVARIRVVGGLAVVLLAGSAVAVSGPVAFIGLAAPHLVRPLLGNDHRWLLPGCLITGPLLLLAADVLGRLVVRPSEIEVGIVTAFLGAPLLAVLARKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N030</accession>
    <name>A0A1E7N030_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2298"/>
    <dbReference type="EnsemblBacteria" id="ARF77905">
        <property type="protein sequence ID" value="ARF77905"/>
        <property type="gene ID" value="B6264_02290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34048">
        <property type="protein sequence ID" value="OEV34048"/>
        <property type="gene ID" value="HS99_0011440"/>
    </dbReference>
    <dbReference type="OMA" id="ETWLIGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="37497" checksum="7CE3932F59FD3DAD" modified="2017-01-18" version="1">MQLDSHTTWATGYQVTVTGPHVRFTPVVVSHDDRRGKQWTELPLPAPDFKMRSNTIAGSSTHDAWVFGDREPTTGRILAEHWDGAHWASTPIEPPPGELYDLNLLGSSAPRPDSAWAVGAASIVTGRTPGPNGGTIINTRTAGLIEHWDGSAWHRMSADGIDGDWWLNSVTEIARDDVWAVGNTAAPDDKPVLLHYDGQAWSRVAAPAFTGLAGEYQSVAASGPKDVWVVGRTILADKDRGHPLVAHFDGRTWTTVQAPEGVAGKLWSVTAVPGGMATVGWDPSGAQDRPIGFRYTHGRWQNLDLSVTGYEDVSYLAVVAAPDNRLTALGTGSTPKSQDYQPLALTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N090</accession>
    <name>A0A1E7N090_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289994.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2369"/>
    <dbReference type="EnsemblBacteria" id="ARF77968">
        <property type="protein sequence ID" value="ARF77968"/>
        <property type="gene ID" value="B6264_02635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34108">
        <property type="protein sequence ID" value="OEV34108"/>
        <property type="gene ID" value="HS99_0011780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24313" checksum="236E5F0323D86A62" modified="2017-01-18" version="1">MSHILVVDDEPALLRTLRINLQARHYSVLTAATGQEALDSAGQAPPDAILLDLGLPDLDGVNVIVGIRSTLSVPIIVLTGRDGIEDKLRAFDAGADDYVTKPFIVDELMARLRAVLRRPAAPALQSAARIGPNAVDLDAGTVTGPDGPVRLTPTEWRILALLLANPGRLVPGRQILTEVWGPEAESRGNYLRVYFSGLRRKLEPDPARPRHLITEPGIGYRYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q9</accession>
    <name>A0A1E7N0Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550823.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2603"/>
    <dbReference type="EnsemblBacteria" id="OEV34264">
        <property type="protein sequence ID" value="OEV34264"/>
        <property type="gene ID" value="HS99_0036675"/>
    </dbReference>
    <dbReference type="OMA" id="RIAQWAP"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2021"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2091"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2107"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2148" mass="225843" checksum="C01C8F08A17F711F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S4</accession>
    <name>A0A1E7N0S4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0036745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2589"/>
    <dbReference type="EnsemblBacteria" id="OEV34276">
        <property type="protein sequence ID" value="OEV34276"/>
        <property type="gene ID" value="HS99_0036745"/>
    </dbReference>
    <dbReference type="OMA" id="PARMLTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198627" description="Histidine kinase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="187"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="251"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="458" mass="48703" checksum="AC0C016CC690D35D" modified="2017-01-18" version="1">MTAHARWRRRRPLRTRLALACTAAVALVAVGVSAAAFTVVRYELEHQLDLHLVQQATLVQQQHRGQGPQVVYGECGYLAAPACAQIVPADPAKDPAQPYLLPVTAATRQVAARERGGRFTDLTIGGHPARMLTTPMTTTPAGIRQAVQVALRADTVQEGVRQAGELMAAVAAAGVLLAAALGHTVARTGLAPVTRLTRTAERIADTRDAGLRIELPPGRREDELTRLAGSFNTMLGELEQSVAAQRRLVADASHELRTPLTALRTNAELLARADRLTDGQRERAAAALGRQLREVTGMVNDLIELARDEEPQPLLEEVRVGPLVAHSVDAAREHWPAIGFTLVDTAGERTVPGVPARLARLLSNLLDNAAKFSPAGGTVEVRLTAGLELTVRDHGPGITPEDLPYVFDRFYRASAARALPGSGLGLAMARQIARAHGATLTAENAPGGGALFRLALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N113</accession>
    <name>A0A1E7N113_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553553.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3933"/>
    <dbReference type="EnsemblBacteria" id="OEV34379">
        <property type="protein sequence ID" value="OEV34379"/>
        <property type="gene ID" value="HS99_0036275"/>
    </dbReference>
    <dbReference type="OMA" id="NAKSYGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198636" evidence="2">
        <location>
            <begin position="32"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="24630" checksum="C41C5DE0C1893D4E" modified="2017-01-18" version="1">MPAPARGAIAIAAAVLLAAAAGCSSGGGHTAKDGSHSKDGAHGSAPAAAGDAAQPAPAKIVTGPGPKSSYDAQPQPAAGSCHYHYTADKQPLPDPNCTPGAISPAVNQGNINDTICKPGGYTSTIRPPANITGKEKAENAKSYGYTGPMGDAEYDHLISLQLGGDPNDPRNLWIQPPSPGHVPGKGPNNPKDSVETHLHTAICKGQVTLTAVQQAIATDWTTAEVKLGISKGATAAPTAEADADGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L7</accession>
    <name>A0A1E7N1L7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552808.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5569"/>
    <dbReference type="EnsemblBacteria" id="OEV34577">
        <property type="protein sequence ID" value="OEV34577"/>
        <property type="gene ID" value="HS99_0035295"/>
    </dbReference>
    <dbReference type="OMA" id="AAHITNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="52006" checksum="F4B00538C21CF8CC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V6</accession>
    <name>A0A1E7N1V6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000831.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81973">
        <property type="protein sequence ID" value="ARF81973"/>
        <property type="gene ID" value="B6264_26560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34662">
        <property type="protein sequence ID" value="OEV34662"/>
        <property type="gene ID" value="HS99_0009215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="9474" checksum="5F384272669B1434" modified="2017-01-18" version="1">MGTVTVSNGDAALGVGGGIANLGGSVTITAGAVRGSHASYGGGIYTDTALTMTASSVTGNTASVNGGVIYRNAGSITLLASIVAGNAPNNCAATTPLTAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y0</accession>
    <name>A0A1E7N1Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555962.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4665"/>
    <dbReference type="EnsemblBacteria" id="ARF81938">
        <property type="protein sequence ID" value="ARF81938"/>
        <property type="gene ID" value="B6264_26360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34698">
        <property type="protein sequence ID" value="OEV34698"/>
        <property type="gene ID" value="HS99_0009420"/>
    </dbReference>
    <dbReference type="OMA" id="ARRDKYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="415" mass="45042" checksum="C98F379644B53751" modified="2017-01-18" version="1">MSAFRVAVVDAFGTSFGFTGAFGAVGGEVIQVRSTPDPPVGVDPVDDRSFAHVLLHDGELDVLAAQLAALGPVAVLAGRETGVELADALSERLELASNGTALSSARRDKYVQIETIKAQGVPGMRQLRTGDEAELLAWHEKVGGTVVVKPLRGYWGAGVSFCDLPQDSVAALRRLRSHRTVLGEPITEVVAQEYLVGAEYIVNTVSCAGVHQLTDAWRTERIEANGVRDLVTAQVLLRSDEQPVGELFDYGRRVLDALGIRYGAAHLEIKLTPDGPRLVEVGARVSGLPYYTAEVLGEGQLEWTVDAYARPERFRARAGRPYRRRQAFAWAALVAPASGRLRGYRALDRLEQLASFHSLTVQVRPGDAITATTYDREYPATLTLSHPVDAVLQRDLNTVRYLDGPGMYEITPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D6</accession>
    <name>A0A1E7N2D6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557752.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7615"/>
    <dbReference type="EnsemblBacteria" id="ARF81794">
        <property type="protein sequence ID" value="ARF81794"/>
        <property type="gene ID" value="B6264_25440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34844">
        <property type="protein sequence ID" value="OEV34844"/>
        <property type="gene ID" value="HS99_0010280"/>
    </dbReference>
    <dbReference type="OMA" id="RWGDLQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20502" checksum="3CF12015BE8C813C" modified="2017-01-18" version="1">MSARATTRPGGRSARVQQSVHQAVRDLEAELGRDALTVPLIAARAGVTPSTVYRRWGDLRELLSDVAVERLRPDALPADHGSLRADLEAWAAQFADEMSSAAGRTYIRDALLGDPEQGNAARCSDYAAEQLKAIGVRAAGRGEAVPGVETLLDVVVAPLMYRILFRPSDLSEGYTGHLVAAALGGDSAPSAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2V0</accession>
    <name>A0A1E7N2V0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0034365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290526.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4697"/>
    <dbReference type="EnsemblBacteria" id="OEV35021">
        <property type="protein sequence ID" value="OEV35021"/>
        <property type="gene ID" value="HS99_0034365"/>
    </dbReference>
    <dbReference type="OMA" id="YEEHGRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20588" checksum="E13A67240B8DB2FA" modified="2017-01-18" version="1">MARTRPGGPQDAADEALIRTLYEQHGGALLAYAVRLTGDRAAAEDAVQETLIRAWRNPEALTEARGSVRGWLLTVERNLITDRFRARAARPAEVAEVSEATATVPVERDHAEGVVETLVMSQALDRLSPEHRDVLRSIYFQRLSVTEAAEQLGIPAGTVKSRAHYALRALRRSYTDRTGTWQEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2W3</accession>
    <name>A0A1E7N2W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35005">
        <property type="protein sequence ID" value="OEV35005"/>
        <property type="gene ID" value="HS99_0034270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8506" checksum="38928BA44208083D" modified="2017-01-18" version="1">MLDSPFGVRLIKTGSLGEYALCLLWGLRAAGLVRGWEAGDVCGAGRVRRCRLAGGWRGCREVGEGRGEGVGGGGEEGAGGGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N302</accession>
    <name>A0A1E7N302_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552913.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35056">
        <property type="protein sequence ID" value="OEV35056"/>
        <property type="gene ID" value="HS99_0034555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="22786" checksum="FF4F9A4735F07121" modified="2017-01-18" version="1">MAGGRDETVAQAGGQGSFDVVRRGYDTAAVDAYLALPPELRPTAPRFEVARRGYDRAQVDRAVAAARTVVGLDPASAPVAAPVPGEASAGGAGRRGFDLVRHGYDTAAVDAYLAQAPDRRQPRPRFRVVARGYAPGQVDRAVTEAFDAQTAALPLPVFATAWRGYDTGAVDAFLALAPHHRPDTPVFAVVRGGYRRTQVDAYLHATTHRPMPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N331</accession>
    <name>A0A1E7N331_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">HS99_0034015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene421"/>
    <dbReference type="EnsemblBacteria" id="ARF78884">
        <property type="protein sequence ID" value="ARF78884"/>
        <property type="gene ID" value="B6264_08110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35082">
        <property type="protein sequence ID" value="OEV35082"/>
        <property type="gene ID" value="HS99_0034015"/>
    </dbReference>
    <dbReference type="OMA" id="AKVCQRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9396" checksum="88902F292481CFA0" modified="2017-01-18" version="1">MAEQQGQQEPQAATAPTPDDALGYEHARDALLEVVRQLENGGISLEESLALWERGEQLAKVCQRWLDGARARLDAALAAEEGAGPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H7</accession>
    <name>A0A1E7N3H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555325.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1390"/>
    <dbReference type="EnsemblBacteria" id="ARF82746">
        <property type="protein sequence ID" value="ARF82746"/>
        <property type="gene ID" value="B6264_10320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35251">
        <property type="protein sequence ID" value="OEV35251"/>
        <property type="gene ID" value="HS99_0033290"/>
    </dbReference>
    <dbReference type="OMA" id="WTMATAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="37286" checksum="8DC932F06F92B078" modified="2017-01-18" version="1">MTGIFSVVTTEILPIGLLTPIGDTFRISDGTAGLMMTLPGIVAAVAAPVVTVAVRRADRRRVLCGLMLALALADLVSALAPGYWAVLAARIVLGVVIGGFWSVGAGLAPRLVAGAEWQARANTVIFSAVPLGSVLGVPAGVLLGHLAGWRAAFAAMALLTLAVFAALAATLPPLPPEAPTRLAVLRGLLRTRSVRAGLVVTLLLVSAHFGTYTYVTPFLEDVTQAGPDAVTALLLVYGAAGVVGNVVGGVWAGRRRATFTLAIGLLAAAVLLLPALGTTWPVAALLLAAWGLAYGAVPVCAQTWFVRAAPHAPEAATVVFTSSFQAAISLGALVGGAVVDASSPSTVLLLGGCVALVAAAVAHVSAAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R9</accession>
    <name>A0A1E7N3R9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550644.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2446"/>
    <dbReference type="EnsemblBacteria" id="OEV35338">
        <property type="protein sequence ID" value="OEV35338"/>
        <property type="gene ID" value="HS99_0032465"/>
    </dbReference>
    <dbReference type="OMA" id="FETNTRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198735" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="213"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1163" mass="117259" checksum="D6A1A43A4487B25E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N441</accession>
    <name>A0A1E7N441_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283408.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3886"/>
    <dbReference type="EnsemblBacteria" id="OEV35457">
        <property type="protein sequence ID" value="OEV35457"/>
        <property type="gene ID" value="HS99_0032380"/>
    </dbReference>
    <dbReference type="OMA" id="GYNGWHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="441" mass="46945" checksum="8CD049C041047399" modified="2017-01-18" version="1">MDAEEFSLPRSRSANERLHALVPGGAHTYAKGDDQYPDGLAPVISHGRGAHVWDVDGNRYVEYGSGLRSVSLGHAHPRVLEAVRRELDRGSNFVRPSVVEVEAAEHFLATVPTAEMVKFAKNGSDVTTAAVRLARAVTGRRLVAVCGDQPFFSVDDWFIGTTPMSAGIPAATTELTVAFPYGDLAATEELLTRYRGEVACLVLEPAGHTEPPPGYLAGLRELADRHGCVLVFDEMITGFRWSEAGAQGLYGVAPDLSTFGKALGNGFAVSALAGRRDLMERGGLRGVGDRVFLLSTTHGAETHSLAAAMAVQTTYVEEGVTARLHALGERLAAGVREAAAATGVGDHVVVRGRASNLVYATLDERRQPSQPYRTLFLRQLLAGGVLAPSFVVSSALDEADIDHTVDVVAGACAVYRKALDAGDPTPWLGGRPVKPVFRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K5</accession>
    <name>A0A1E7N4K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched chain amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene955"/>
    <dbReference type="EnsemblBacteria" id="ARF80821">
        <property type="protein sequence ID" value="ARF80821"/>
        <property type="gene ID" value="B6264_19625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35627">
        <property type="protein sequence ID" value="OEV35627"/>
        <property type="gene ID" value="HS99_0006855"/>
    </dbReference>
    <dbReference type="OMA" id="YGVGFEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="414" mass="43225" checksum="CE1C2DFB9A2BE873" modified="2017-01-18" version="1">MRHRSAIVVSIAVIGALSLSACGSRGGKSGDNAGSKDNNAATTTVVIGVDAPLTGDLSALGLGIRNSVDLAVKTANATNEVPGVKFEVKALDDTAKPAPGQQNATQLVSDSKVLGVVGPLNSSVAQSMQQIFDDAGLTEISPANTGVALSQGEKWATGDKKRPFKSYFRTATTDAVQGPFAAQFLYNDAKKTKVFLIDDQKTYGAGLAATFKGQFTKLGGTLAGEEHVNPDDRDFSAIVTKVKASGADAVYYGGEYPAAGPLSLQLKDAGVNIPLMGGDGIQSDEFIKLNPKSQGDFATAVGLPVETLDTAKKFIADYKAANYKDAYETYGGYSYDSAWAIIEGVKNVVAANNGKLPSGDARKAVRDAVQKVSFNGVTGKVSFDEFGDTTNKQLTVYTVKDGKWAVEKSGTFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P8</accession>
    <name>A0A1E7N4P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386780.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene911"/>
    <dbReference type="EnsemblBacteria" id="ARF80860">
        <property type="protein sequence ID" value="ARF80860"/>
        <property type="gene ID" value="B6264_19845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35666">
        <property type="protein sequence ID" value="OEV35666"/>
        <property type="gene ID" value="HS99_0007075"/>
    </dbReference>
    <dbReference type="OMA" id="TRCALYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="19252" checksum="94D617C0D3D6F48E" modified="2017-01-18" version="1">MTAIPDGGRTTGPRSGDLLTIGQLAARSGLAASALRYYESLGLIHATRTSGGQRRYLRGTLRRIAFVRAAQRVGLSLDEARVALDRLPERPAPSGAEWTAVAASWQGRIDEQIAELELLKAKLTGCIGCGCLSLTRCALYNADDRAAQAGPGARYLLTRDPATGPEPAPADVPGGGGRRDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U6</accession>
    <name>A0A1E7N4U6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0031755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278152.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5543"/>
    <dbReference type="EnsemblBacteria" id="ARF79371">
        <property type="protein sequence ID" value="ARF79371"/>
        <property type="gene ID" value="B6264_10950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35483">
        <property type="protein sequence ID" value="OEV35483"/>
        <property type="gene ID" value="HS99_0031755"/>
    </dbReference>
    <dbReference type="OMA" id="AWMPTIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="41731" checksum="0413ACD11548C696" modified="2017-01-18" version="1">MAVTRAPQPVATTPAPLPVRTRLAHPALLLAGILLVALNMRACLAAVSPMVAEIQRTFGLSSTASGLITTVPVLFQGVGAPLTPRLTRRFGAERVVLGAVLVLGAGVLLRVLPSVFALYAGCVVIGVAIAVLNVSMPGLVKREFPDRAATMTGVYSTTMLVGATLAAGTSVPLEHALGGGWRASLGAWSLLALVAAVAWLPQVLRSRQEKAAVAAAAQPGKPIENLWKSPLAWQISLFMGISSLLVYTLVAWMPTILADHGMDRGQAGLVFAFSNLVQVAGAFLVPLLAGRMTSQRALAVTMAALNGLGIALLLVAPVSGAWVSAAILGVAQGGSLGLGLAFIVLRTGTAAGAAQLGGMSQAIGYLVAAAGPVGAGALHQLTGGWEATLVLMLVLVAVVGAAGLGAGRNRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X8</accession>
    <name>A0A1E7N4X8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80953">
        <property type="protein sequence ID" value="ARF80953"/>
        <property type="gene ID" value="B6264_20400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35746">
        <property type="protein sequence ID" value="OEV35746"/>
        <property type="gene ID" value="HS99_0007625"/>
    </dbReference>
    <dbReference type="OMA" id="LGRICHS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="18873" checksum="B30DEAA7869D8823" modified="2017-01-18" version="1">MISAVLGGMPNFWPGLLLSLVPAALLNRPVGRLLRAHWVVGFLLLLGLGGVVVATLLPEAFRPSVLRHAAEAARHCSVAGARPRSPYELLHVRHIELKLATYAPVGFAAALAGTRRRAAVALLGTAMLPFAVSGLQYAVPALGRACDVQDVWDGVQGVVLGAALGLVVGPVARAMTRARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B3</accession>
    <name>A0A1E7N5B3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0008490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553604.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7266"/>
    <dbReference type="EnsemblBacteria" id="ARF81098">
        <property type="protein sequence ID" value="ARF81098"/>
        <property type="gene ID" value="B6264_21265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35887">
        <property type="protein sequence ID" value="OEV35887"/>
        <property type="gene ID" value="HS99_0008490"/>
    </dbReference>
    <dbReference type="OMA" id="HDLHIWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="359" mass="37688" checksum="B4245E6C12C96639" modified="2017-01-18" version="1">MAGHEHHDDHAHDHQTPPGRSHNHSHGHGGHGHGGHGGHSHGVAADADRRWLVSALALIVVFMAGEVVVGFAARSLALISDAAHMLTDAASIVLALVAMRLAARPARGGYTYGLKRAEILSAQANGVTLLVLSAWLGYEAITRLIEPPEVTGSLVLVTALVGIVVNLAAAWCMSKANRSSLNVEGAFQHVLTDLYAFIATAVAGAVMLTTGFVRADAIASLIVVALMLKAGIGLVRDSGRIFLEAAPAGIDPDAVADRLVTQPLVEEIHDLHIWEITSNQPALSAHILVTPGGDCHAVRRALQRRLAEEYGITHSTLQVDHVGEDEAGALLQIAGPDDTPAEHCADAHGPVHRAGPHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F3</accession>
    <name>A0A1E7N5F3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553645.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7313"/>
    <dbReference type="EnsemblBacteria" id="ARF81141">
        <property type="protein sequence ID" value="ARF81141"/>
        <property type="gene ID" value="B6264_21500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35927">
        <property type="protein sequence ID" value="OEV35927"/>
        <property type="gene ID" value="HS99_0008725"/>
    </dbReference>
    <dbReference type="OMA" id="GYHVHRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28476" checksum="A4D56936961AC537" modified="2017-01-18" version="1">MSEPSTITDPADPRLADYTGLTDVELRRRREPAEGLFIAEGEKVIRRALSAGYRMRSMLLTAKWLDVMADVIADADADAPVHVVEPALAEAVTGYHVHRGALASMERKPLPDAASLLTGARRVAVLEGLVDHTNLGAIFRSAAALGMDAVLLSPDCADPLYRRAVKVSMGAVFAVPYARLDPWPAALDTVRDAGFTLLALTPAETAVDLATLTPHTLPRTALLLGAEGDGLTPRAIAAAHHPVRIPMAHGIDSLNVGAAAAVAFYAVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N9</accession>
    <name>A0A1E7N5N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737903.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene765"/>
    <dbReference type="EnsemblBacteria" id="ARF80984">
        <property type="protein sequence ID" value="ARF80984"/>
        <property type="gene ID" value="B6264_20595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35773">
        <property type="protein sequence ID" value="OEV35773"/>
        <property type="gene ID" value="HS99_0007820"/>
    </dbReference>
    <dbReference type="OMA" id="KRTMIWC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="477" mass="48424" checksum="B2BF5EE75C5CAE9E" modified="2017-01-18" version="1">MRPDSLWRIPDFRVLFAATALTQLGTNVGYVAVPLVAVAALGAGPGQAGLLATLSTLAFLLIGLPAGAWVDRMRHRRVLVVADLVKAVLYASVPLAWWFGGLSLGQLYAVALLTGGATVFFDVGAQSVLPGLVGRRHLVDANAAVVGLMAIGNVAGRGAGGILVQLLTAPLAIAVTALSHLGSALRLTALRRTTTPATTTPATPTAAPTPATPVPTAPTPMAPTPGLGAQITEGLRHVLGAPELRALAVTAALNNLGSQLFNTLLPVLFVRELHLPAGALGLFWAVGGVGILLGSRCARPICARLGDGRTLALAGLCLAPAGLLVPLIGDGPRLLLAGAGWLLVSLKTGMDNVLGVSLRQRMTPDPLLGRMNATFRFLLFGALAVGSAISGLLGELFGTHATLWLGGAVLATAFLPVYLSPLRTRRRPPVAPPVAPPGVLPGAPPAVDAATSPGRRRAPAASPVPGSGADEGCAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X1</accession>
    <name>A0A1E7N5X1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280970.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4968"/>
    <dbReference type="EnsemblBacteria" id="ARF80036">
        <property type="protein sequence ID" value="ARF80036"/>
        <property type="gene ID" value="B6264_14940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36092">
        <property type="protein sequence ID" value="OEV36092"/>
        <property type="gene ID" value="HS99_0030960"/>
    </dbReference>
    <dbReference type="OMA" id="LYCVQPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="43618" checksum="321024B681CF20F6" modified="2017-01-18" version="1">MQPSDTRASAPAPDASTARTPGALGLGHDDRHRPGQRDFRRANLALFAAGIATFVLLYSTQGLLPVLSADLDLTPGQASWTASAATLGLALGLLPASALSDRYGRTAVMTASTLAASALAVALPFAPDLTTLVALRVVQGAALAGLPATAMAYLAEEVHPSALASAMGLYVAGNSIGGMGGRLLSGWTAAALGWRWGLAASAALALLAALAFRLLIPAARHFTPAPVDARALARTVGRHLRNPLLVRLYALGMLFMAVFGAVYNTVGYRLIAAPFHLPESIAASIFVVYLVGTGTSAAAGRLSARLGRRGALYVAIGVTAAGLLLSLADSLPCALLGLVLITAGFFAGHATASAAVGRTATEGRAQASALYLIAYYLGNSLGGTLGADAYHSTGWPGAATVGLTAMTLAAAVTLYATHQAHTTRRAVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N603</accession>
    <name>A0A1E7N603_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553180.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000457.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5003"/>
    <dbReference type="EnsemblBacteria" id="ARF80068">
        <property type="protein sequence ID" value="ARF80068"/>
        <property type="gene ID" value="B6264_15110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36122">
        <property type="protein sequence ID" value="OEV36122"/>
        <property type="gene ID" value="HS99_0031130"/>
    </dbReference>
    <dbReference type="OMA" id="VYFSIEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="42449" checksum="2351EEBB9C14B268" modified="2017-01-18" version="1">MNRPAHILMVSVPAHGHVNPSLAVITELVARGYRVSYVNDPSFREIVESTGASFVPYATALPLTDDPAGWPEDPVAIQEVFLDDALSMWSALLEAFEDDHPDLVLYDIAGFAGRALGERLGVPVVQLSSSFVGWDGGEEDLAEVFEAIRSGPGGPEHHRRFADWLAGAGAVQRDVEAFKNRPERCIALVPRALQPNADRVDERRVSFVGPCFGDRAHQGRWERPAGAEKVLLVSLGSAYTNQPAFYRACIEAFGDLPGWHTVLQIGRHTDLAALGEVPDTVEVHRWVPQLSVLAQADAFVTHAGMGGSSEGLFHAVPMIAVPQAVDQFANADALVGLGVARRLDTEQATAEALRAALLELVDDPAVAERLAVLSAAGRAEGGTVRAVDLIEAELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N679</accession>
    <name>A0A1E7N679_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8096"/>
    <dbReference type="EnsemblBacteria" id="ARF79797">
        <property type="protein sequence ID" value="ARF79797"/>
        <property type="gene ID" value="B6264_13570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36185">
        <property type="protein sequence ID" value="OEV36185"/>
        <property type="gene ID" value="HS99_0030520"/>
    </dbReference>
    <dbReference type="OMA" id="ADVTFVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="43986" checksum="752411D1624529CA" modified="2017-01-18" version="1">MLDEEFVRSATVKEQSGRTRMLAARWKHTPPVDPGGRRSVNDGPATPKRRFGRRPELRVVDPWGNPRPARRRGGWWRTPLVVLLVVAGLLASLNVNAVSNWVSGLRSSKADAPVPVVAPETARPTTAPPDTPDDQPTVDHPWKASPAAGWPTGTEAMVLPEAKATGVFSADEVAAQLQQVKDYLAAANLDPKVIAGARPDAALAMLDHEDRKDAADALDHPGKDHDPLSWFSRFDPREAVLVGDAVKVQGRLSYEGDGDGGVLIHTDFTFVYPLQPGPDARKLAEDRPAPSATPSAPQGGSARPVGLVEPAAASSGDTWTTRTIVRRVGDYRFYDPDRHQVDAKKIVLGKAMSDVGNNACSVYDGFVHPQFRQFARPHPEQTGPTTDPYDRSHDLAPSGQCGTTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6B2</accession>
    <name>A0A1E7N6B2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551612.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8093"/>
    <dbReference type="EnsemblBacteria" id="OEV36246">
        <property type="protein sequence ID" value="OEV36246"/>
        <property type="gene ID" value="HS99_0030535"/>
    </dbReference>
    <dbReference type="OMA" id="NIFNYVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="40396" checksum="7EA58F4385A8B34D" modified="2017-01-18" version="1">MAPGLRVGRAALAVSFLLQGTTFALLVTCIPEIQHRYGLSDGMLPVFLAAVPILAGVGSILSEQLVKRTGARAVLRVVQPAVCLSLAGAGLGGSLWQLALALGAFGLLVGALDASMNMLGVGLQHRYGRSIMIGFHAAFSLGGILGAGIAGLGSHYDLGLPVLFGTAGAVIAPLAVLTGTLPQPSAGGTPTAGPAELGDAVREAAEAAARSIPWRPLLPLCLAMACAYIADASVSNYSVKYLTDVLGSREDLAKLSYLGYMVAMLLGRALGDRAVQRFGTVAVVRGGAALAALGFGLAAVAPAAWAGIASFTVLGFGICAIIPQVFAAGGRLFPADSDAAVARLNLFNYVGFLIGSPLVGAVADASSYRWALLAPMLLVLAVLPLAERFAPAPVAAPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J0</accession>
    <name>A0A1E7N6J0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0031680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6350"/>
    <dbReference type="EnsemblBacteria" id="ARF82683">
        <property type="protein sequence ID" value="ARF82683"/>
        <property type="gene ID" value="B6264_07445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36073">
        <property type="protein sequence ID" value="OEV36073"/>
        <property type="gene ID" value="HS99_0031680"/>
    </dbReference>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="806" mass="87780" checksum="8F6E291B9E83AA26" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6S4</accession>
    <name>A0A1E7N6S4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554791.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7743"/>
    <dbReference type="EnsemblBacteria" id="ARF82319">
        <property type="protein sequence ID" value="ARF82319"/>
        <property type="gene ID" value="B6264_28675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36390">
        <property type="protein sequence ID" value="OEV36390"/>
        <property type="gene ID" value="HS99_0029990"/>
    </dbReference>
    <dbReference type="OMA" id="ELWHATT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="24384" checksum="BDADB852A102B0FE" modified="2017-01-18" version="1">MTTVRTVQLPEVTLAYRESGHPDGPPLVLLHGLGERAAGWDTVLPDLAPHHHVYALDLRGHGDSGRTAAYGLEAMREDVLAFLDALGLDRIALVGHSMGGAVAYLVAQAAPERIDRLVLEEIAALYPRPSSVPPEGADEPAHFDWAMVRAVKAQLDTPDPAWREGLTRITAPTLAVAGGPSSHVPQERIAELARLIPDCRLVSIEAGHLVHNARPAEFVAAVAPFLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W5</accession>
    <name>A0A1E7N6W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280540.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82325">
        <property type="protein sequence ID" value="ARF82325"/>
        <property type="gene ID" value="B6264_28705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36384">
        <property type="protein sequence ID" value="OEV36384"/>
        <property type="gene ID" value="HS99_0029960"/>
    </dbReference>
    <dbReference type="OMA" id="GAKCCTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="30439" checksum="6E231A6A16285BE1" modified="2017-01-18" version="1">MSTHTPARTARPRRYLMCRPTHFTVDYAINPWMDPAQPTDTELAVRQWERLYRTYRRLGHTVELIDPVPGLPDMVYAANGATVLDGRALVATFRYPERAAESEAYQSWFRLHGYRAVRRAGHVNEGEGDHLVVGRRVLAGTGFRTSRAAHAEAEQLFGVPVVSLTLVDPRFYHLDTALAVLADDHVMYYPEAFDANSRSVLRSLYPDAVLADRADAEVFGLNAVSDGRRVLLPEAAKNLAGRLAEHGYEPIPVDVSELLKGGGGAKCCTLELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N755</accession>
    <name>A0A1E7N755_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386507.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000382.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1474"/>
    <dbReference type="EnsemblBacteria" id="OEV36508">
        <property type="protein sequence ID" value="OEV36508"/>
        <property type="gene ID" value="HS99_0028685"/>
    </dbReference>
    <dbReference type="OMA" id="VQPFTNM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009028451" evidence="1">
        <location>
            <begin position="32"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="46"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="385"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="599" mass="62389" checksum="E0F44A6A81F040BC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J8</accession>
    <name>A0A1E7N7J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554820.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000727.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82303">
        <property type="protein sequence ID" value="ARF82303"/>
        <property type="gene ID" value="B6264_28575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36614">
        <property type="protein sequence ID" value="OEV36614"/>
        <property type="gene ID" value="HS99_0027940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10283" checksum="A9D08978E14071E9" modified="2017-01-18" version="1">MLAVLAVLAVLAVLAVLATGEMPLSLTEFTAEGARTELSARWPVVGPDSPDSPDGWTVRARARAEPVDAAAPLDQCQGESPKPRTGWREPDHGHRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K7</accession>
    <name>A0A1E7N7K7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835464.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36671">
        <property type="protein sequence ID" value="OEV36671"/>
        <property type="gene ID" value="HS99_0028305"/>
    </dbReference>
    <dbReference type="OMA" id="WIGHNGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198850" description="Beta-lactamase domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="50601" checksum="3AF9DA3178DDDB1A" modified="2017-01-18" version="1">MTKTRRPRPAESRTAATRMAATRTAGRAAAAALALTGLLAAAGCSGDSKPARQGGREVTAEPAALGPSGGTAGSGGSPSGSASSNAVVALTPAVTGRLDDAIQRVQKQTGVPGVSVGIITPSGTYQKSFGVADKSANTPMDPGMYSRIGSESKTYTATAVLRLVDQGKVGLDDPISKYVDGVPGGDGITVRQLGEMRSGLFPYTSDQDFVNAFINDPNHVFTPDELLAYGYRHPAVFPPGSKFQYSNSNYILLGKLIEQVGGQSAGDFLQAQVFSPASLGKTSFPTDATLPDPHAHGYTNQTPDGSVQDATGWNPSWAWTAGAVITTLGDLESWAKTVATGSVISPASQTERMKTLPTDAPNVSYGFGLFNNNGWIGHNGSMPGYESVAVYMPDAQATLVMLLNTDVLSQGQEPSTLFANEITKIISPKHVYALPAETASPSAPGSASGSPSGSPSGSPSGSPSGSPSGSPSGAPSGSPSGSPSASLPTNTASTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N9</accession>
    <name>A0A1E7N7N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550683.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2481"/>
    <dbReference type="EnsemblBacteria" id="ARF81517">
        <property type="protein sequence ID" value="ARF81517"/>
        <property type="gene ID" value="B6264_23705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36689">
        <property type="protein sequence ID" value="OEV36689"/>
        <property type="gene ID" value="HS99_0028420"/>
    </dbReference>
    <dbReference type="OMA" id="WLMQRAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="533" mass="55959" checksum="3D954795875968DB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P7</accession>
    <name>A0A1E7N7P7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388142.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000907.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2466"/>
    <dbReference type="EnsemblBacteria" id="ARF81529">
        <property type="protein sequence ID" value="ARF81529"/>
        <property type="gene ID" value="B6264_23780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36699">
        <property type="protein sequence ID" value="OEV36699"/>
        <property type="gene ID" value="HS99_0028495"/>
    </dbReference>
    <dbReference type="OMA" id="RIVRTEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="38705" checksum="0A7C707A77F7A49D" modified="2017-01-18" version="1">MTVLGTRALSRALLARQHLLARTDRTPLEVIHHLGGLQAQAAPQPPYLGLLSRLDGFAPEQLTGLIEQRAVVRIALQRGTIHLVTAEDCLTLRPLLQPVLDQALRTTYGKRLAGLDLAVLAAEARALVEEEPRTFQRLGALLAATRPDRDPAALAQAARCLLPLVQVPPRGLWGRGGPAAHTTAEAWLGRPLDPEPSPDGLVLRYLAAFGPAGAADLRKWCGLPGLGPVLQRVAPRLLTFRDEQGRLLYDLPQAPRPEPDAPAPVRLVAPFDNLLLSHADRSRVLPEEYKGRVMTRNGLVPGTLLVDGLVAGTWGLTGEREVAVQPFVRLAPADREAAEAEAHRVLAFAGGGGAVRIEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T3</accession>
    <name>A0A1E7N7T3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829715.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4767"/>
    <dbReference type="EnsemblBacteria" id="OEV36745">
        <property type="protein sequence ID" value="OEV36745"/>
        <property type="gene ID" value="HS99_0027395"/>
    </dbReference>
    <dbReference type="OMA" id="AGNCYAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198943" evidence="2">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="17361" checksum="11B21E767063D60C" modified="2017-01-18" version="1">MTSRIARRRAAGLAGFAGLVLTVGLTLTGCDPSAADGKASSAPTASAGSTVPPTPSAPPATTPAQAAPAITPSTPPTSPSTPPPSASSAPSAAHPQTPAAKPQPKVTTAQPPTDPETQRTQAAAGGSGCEIRSNAGNCYAAGQFCRNDDLGRSTHDANGRVIYCRVVSGKPHWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N883</accession>
    <name>A0A1E7N883_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6461"/>
    <dbReference type="EnsemblBacteria" id="OEV36878">
        <property type="protein sequence ID" value="OEV36878"/>
        <property type="gene ID" value="HS99_0026800"/>
    </dbReference>
    <dbReference type="OMA" id="ESYLMHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="26414" checksum="FDD3C0F791F2FEAB" modified="2017-01-18" version="1">MSVRESGSGTPLVLLHAFPLNASMWSAQLDALPGPTGDEARVLAPDQRGFGGTELGADEPSLDLVADDLALLLDAAGIDRAVVGGLSMGGYVALAFARRHPDRLAGLLLSNTRATADTDAARANRERIAAAVTARDSVQLLLDERVAAGQLGPDSQHLVERVQAMVAAAPPAAVAWAQRAMAARPDSLDVLAGLRVPLAVVAGALDALAPLEEAERMVQAGPDAELTVVPGVGHLSALESPGAFDAAVRRLLARVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R6</accession>
    <name>A0A1E7N8R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555775.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000796.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6690"/>
    <dbReference type="EnsemblBacteria" id="ARF81631">
        <property type="protein sequence ID" value="ARF81631"/>
        <property type="gene ID" value="B6264_24430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37096">
        <property type="protein sequence ID" value="OEV37096"/>
        <property type="gene ID" value="HS99_0004560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6374" checksum="F40504D985BB8390" modified="2017-01-18" version="1">MTQPDHTGHPAETVTARPATDPLTLVVGVHLVLADDGAVLLGRRRNTSYAAGLWHLPAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N955</accession>
    <name>A0A1E7N955_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555254.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1343"/>
    <dbReference type="EnsemblBacteria" id="OEV37230">
        <property type="protein sequence ID" value="OEV37230"/>
        <property type="gene ID" value="HS99_0005355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="43482" checksum="2EC82C4A62E438DB" modified="2017-01-18" version="1">MRAPAFVPRPAAIVRWREAPSRTLRLPRAPWLSLPEWSTTALTRSVKGLMAALLAWQTASWWLPGHQQYLAVATALAMVNAPTIYRSVTQALRSVAARAAGLSLAVVVVWLLGPAAGSIAAIPAIALVAGGRRGSDSRLQIASTATLTLAAATAFPVGHVITLTLAALTGAAAGIAVNALILPPVHLGASDASVRELAAAMGELLGDMGRGLRERQHADRAHLWLERGRRLDALALQAEEDLRQSQESLRWNTRCIVHGQQEPTDHSKALRALHRVSFQVRGIARTLADTVDDRPTGHDLNRLFLDRYAATLETAERAMESFAAPGHAAGPGLDSFCGPLRRAIDDATTWHRTMTEEIRHGTLAEPGAWHVYGSLITDIERLLADLERANRPAPTTPGPRPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C1</accession>
    <name>A0A1E7N9C1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555116.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37292">
        <property type="protein sequence ID" value="OEV37292"/>
        <property type="gene ID" value="HS99_0005730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198904" evidence="3">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="14639" checksum="A28198ED2DCAB572" modified="2017-01-18" version="1">MAGALRLTVMGAVLLLGGLLWGGMPVEAKGGDCGSLWSHSRIHTTMTRDENGMTITSTPEPVECPDAREHRNVLVILVIIMGAAALAAGVAETVRKLLLWSRSVHRRTPPGPRSAPNPPTAPPLGTAPFDPRTPKPPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N4</accession>
    <name>A0A1E7N9N4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5408"/>
    <dbReference type="EnsemblBacteria" id="ARF82492">
        <property type="protein sequence ID" value="ARF82492"/>
        <property type="gene ID" value="B6264_29725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37378">
        <property type="protein sequence ID" value="OEV37378"/>
        <property type="gene ID" value="HS99_0006250"/>
    </dbReference>
    <dbReference type="OMA" id="TAICKVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="44732" checksum="2B1AAA4789B812D6" modified="2017-01-18" version="1">MTPGTITAQITDYANRADPYPLYAELREQPVRREDDGTYLVSTYYEVRNLANDPRLSNDTRNRPPGYARVGHPAEETGLPPSFIFTDPPVHDRLRDTINRPFGPPHSPRFLDGLRADLATVVTELLDAFEGKDQVDIVEDFSYPLPVTAICKVLGVPREDEPRFHIWADALASSLDPRPGGDDGQEKAQRARQDMGAYLSDLIETKRRHPGPGILSALAPDMTPADLEATAVLLLVAGHETTVNAITNTTLTLLRHPDVLERFQKDPDLAVPLIEEVLRFEPPVQFVPWTTALADIDVAGTTIPKGSPVWLMLAAANRDPKRFEDPDRFDPDRKDNEHLGFYTGIHYCFGAPLARIELHAAVPELFRRVKFSGLLEDPPPYRTNAVLRGPRHLPVAIEGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R1</accession>
    <name>A0A1E7N9R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37384">
        <property type="protein sequence ID" value="OEV37384"/>
        <property type="gene ID" value="HS99_0006295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16342" checksum="B93C63260911F3AA" modified="2017-01-18" version="1">MLQPAHDLAQRGGVEVVGEVADGLAVVVGEGVDAGAVEGGVEGLGCGAGEASVGEVGGLVGLVGGLAGTVGDVLPVVLTAQRVLEVIRPSTSTTSPRLRPGTFLPASSPVVVFGTPAAARTDWVSMITRDGSSNRLALSRTWQRSSSCIRWSRPSCRHSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA29</accession>
    <name>A0A1E7NA29_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1144"/>
    <dbReference type="EnsemblBacteria" id="ARF79024">
        <property type="protein sequence ID" value="ARF79024"/>
        <property type="gene ID" value="B6264_08920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37547">
        <property type="protein sequence ID" value="OEV37547"/>
        <property type="gene ID" value="HS99_0026435"/>
    </dbReference>
    <dbReference type="OMA" id="NNRVAYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="25806" checksum="1716065193053092" modified="2017-01-18" version="1">MMTFSRALSAVASAAVLSTIALTGPTATLASAAGSFVVSEAQFNQMFPNRNPFYTYKGLTDALSAYPKFAATGDSATRKREAAAFLANVSHETGGLRYVVEQNTANYGHYCDTTQPYGCPAGRSAYYGRGPLQISWNFNYKAAGDALHIDLLHDPAKVEKDPAVAWKTALWFWDSQKGAGTMTPHDAVVNNKGFGETIRSINGDLECNGKNPDERNDRINLFKRFVGVLGTNVGGGNISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA99</accession>
    <name>A0A1E7NA99_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284170.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8016"/>
    <dbReference type="EnsemblBacteria" id="ARF79864">
        <property type="protein sequence ID" value="ARF79864"/>
        <property type="gene ID" value="B6264_13975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37611">
        <property type="protein sequence ID" value="OEV37611"/>
        <property type="gene ID" value="HS99_0025190"/>
    </dbReference>
    <dbReference type="OMA" id="CVNPFLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="2">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="33394" checksum="AB6FA9F8B0E64344" modified="2017-01-18" version="1">MGFFVFLPLILPLTAVPIARLTEQHLHPRGAARLMTVISAVMAVCSVLCLGLIGVVGTAQIPGNPLPDSWSDPVVRHALPYHETVGTAAMWLLVLVAFTCCRTVVRHLRVRSRARRALAGLPEGSAGEEGLAVLPDRNPYAYALPGSPGRVVVSTGMLDGLAEDEREALLAHERAHLRHRHHRYLLTTQLAACVNPFLRPLQAAVAFSAERWADEESAQAVGDRRITARAVARAALVSHAAPAPGFAAFAAPAAAQPGPVPRRVAALLGPVPTARNWPPAKTPAGLAAMVAAAGTAASALCALNAAVALLVVLKAVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK8</accession>
    <name>A0A1E7NAK8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplB</name>
        <name evidence="5" type="ORF">HS99_0025570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280770.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1680"/>
    <dbReference type="EnsemblBacteria" id="ARF79931">
        <property type="protein sequence ID" value="ARF79931"/>
        <property type="gene ID" value="B6264_14360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37674">
        <property type="protein sequence ID" value="OEV37674"/>
        <property type="gene ID" value="HS99_0025570"/>
    </dbReference>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="30366" checksum="4EB27A9688F7F6E1" modified="2017-01-18" version="1">MGIRKYKPTTPGRRGSSVADFVEITRSTPEKSLVRPLHSKGGRNNAGRVTARHQGGGHKRAYRVIDFRRHDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPRGIAQGDRIENGAGADIKPGNNLPLRNIPVGTTIHAVELRPGGGAKLARSAGSGIQLLAREGRMAHLRMPSGEIRLVDARCRATVGEVGNAEQSNINWGKAGRMRWKGVRPTVRGVAMNPIDHPHGGGEGKTSGGRHPVSPWGKPEGRTRRPNKASDKLIVRRRKTNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAP8</accession>
    <name>A0A1E7NAP8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366513.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3446"/>
    <dbReference type="EnsemblBacteria" id="OEV37761">
        <property type="protein sequence ID" value="OEV37761"/>
        <property type="gene ID" value="HS99_0024500"/>
    </dbReference>
    <dbReference type="OMA" id="NGQGWVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="22433" checksum="D4126B7E576F461A" modified="2017-01-18" version="1">MYSYDVSAPAGRPTTPTRSIPGMRPSYDAEHPHSTTPIYDELYSEYRRLFRALPGDRSGEEDLRFTGFAIRDGYPLRGEQRPHQPQQQAFHTYAGQPSGLPQFVPAQSQPTHPTSHPGHIPAPAPAPAPAATTSDGDGQSHGHAPPPSPQFTNGQGWVAAGYLGPLPHATPAPPPTPAPVLGTATGLAAAQSPGGRHRQLLSLPPGRAGDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV3</accession>
    <name>A0A1E7NAV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3735"/>
    <dbReference type="EnsemblBacteria" id="ARF78043">
        <property type="protein sequence ID" value="ARF78043"/>
        <property type="gene ID" value="B6264_03130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37821">
        <property type="protein sequence ID" value="OEV37821"/>
        <property type="gene ID" value="HS99_0024860"/>
    </dbReference>
    <dbReference type="OMA" id="HADTVWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="40122" checksum="A2423A589736821C" modified="2017-01-18" version="1">MNPATVALTDRAHEVSSEIVDDIMTLVGQETSSYDLAGLAAGRDLLHDLAVHRLGQPGEEHRHRGGERGDTLTLTYPGTAPGHVALVGHYDTVWPTGTLAGWAPPQADGREKLSGPGIFDMKTGLAQGIWALKLAREYGVPVPTVTFVFNGDEEVGSRSSRPVIEEVAHHADVTLVLEPSAHGAVKTARKGNGTFRVTASGVEAHAGLAPEDGASAITALSEFVVAAAAVAAPELGTTINPGLITGGSAANVVAGLATASVDIRVSSEAERERVDAELEAIKVSDPRVRIDIDHAWNRPPMTLNAASAPLLGLAREVAREQGRDGLPAAAVGGASDANFVAALGLPVLCGMGAVGDGAHAQGEFIYPDTVPTQTALVAGLLGRLAEPLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB48</accession>
    <name>A0A1E7NB48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367115.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6005"/>
    <dbReference type="EnsemblBacteria" id="ARF82585">
        <property type="protein sequence ID" value="ARF82585"/>
        <property type="gene ID" value="B6264_02910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37874">
        <property type="protein sequence ID" value="OEV37874"/>
        <property type="gene ID" value="HS99_0025055"/>
    </dbReference>
    <dbReference type="OMA" id="IMERWIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="31344" checksum="1961BD1B1639E1E1" modified="2017-01-18" version="1">MRLPVRPDTVPRWHRDLVARRHAARSRPKRPGRPRTVRSVRALVLRLAAENPAWGYRRLHGELLVLGVKVAASTVWQILKEAGIPPAPERTSSTWASFLRSQADALLACDFFETVTLSGARLHVLAVIEHATRRIRILGATAHPTASWVAQAAKNLVTDLEDAGYRARYMLPDRDGKFPELFDAVLADAGIQVVLSGVRMPRMNSILERWVQTCRRELLDRTLIWDQRHLLHALREFERFYNDHRPHQAIANARPLRPLPAPIDTPEQIARLNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD9</accession>
    <name>A0A1E7NBD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein TraC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7562"/>
    <dbReference type="EnsemblBacteria" id="ARF78082">
        <property type="protein sequence ID" value="ARF78082"/>
        <property type="gene ID" value="B6264_03355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37783">
        <property type="protein sequence ID" value="OEV37783"/>
        <property type="gene ID" value="HS99_0024645"/>
    </dbReference>
    <dbReference type="OMA" id="KRRFMRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="457"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="596" mass="64300" checksum="5AD88923CA7DCB57" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBH9</accession>
    <name>A0A1E7NBH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385853.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000143_gene3680"/>
    <dbReference type="EnsemblBacteria" id="OEV37823">
        <property type="protein sequence ID" value="OEV37823"/>
        <property type="gene ID" value="HS99_0024880"/>
    </dbReference>
    <dbReference type="OMA" id="LPNGPHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22900" checksum="C521AC16BD73A9AB" modified="2017-01-18" version="1">MNDTQSIENPWGMSVFGAASVDAAPDLARLRVAINQTRQKPGEAFEVTRAAVNQVREALRNHNVPDSAVSTSQLDLKSSWTYGGERKFLGYECTASFVIELRELDRLETVLVDVVDAGANQVDGVTFDVQAKKELRAMARAAAVAAAREKAALYAEAAGARLGPVIHIKDIDSDHLQNSYRSHRSSGDGSGDGDLTPGKISISAGVVIGFSLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT9</accession>
    <name>A0A1E7NBT9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2304 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287384.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene458"/>
    <dbReference type="EnsemblBacteria" id="ARF78855">
        <property type="protein sequence ID" value="ARF78855"/>
        <property type="gene ID" value="B6264_07935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38161">
        <property type="protein sequence ID" value="OEV38161"/>
        <property type="gene ID" value="HS99_0023520"/>
    </dbReference>
    <dbReference type="OMA" id="GHAVVCM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6630" checksum="A162C3C7A9AFC507" modified="2017-01-18" version="1">MAMNVSAAVLMLVIVVVMVRRAGLKLSHAIVCALLGFYLASSSIAPSITQVTSNLAGMINGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC02</accession>
    <name>A0A1E7NC02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3314"/>
    <dbReference type="EnsemblBacteria" id="ARF80268">
        <property type="protein sequence ID" value="ARF80268"/>
        <property type="gene ID" value="B6264_16335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38222">
        <property type="protein sequence ID" value="OEV38222"/>
        <property type="gene ID" value="HS99_0021945"/>
    </dbReference>
    <dbReference type="OMA" id="GARFMDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23453" checksum="070CA0600D55414A" modified="2017-01-18" version="1">MPRSFPEQLADLPYAELLRPHAGPLRSDARYDTTHFDGGGHTDESAAGAVFLECAFTGVSLSGVKLRQARFNEVWVQAGRWVACDLSDTEWQDSAFLGGVLAGVAGYGSALRRVVFRGCKLEAVNLRAAVLRDVVFEDCLLRDVDFGEAKLTGVSFPGSTLEEVRLRGAVLSGTDLRGAARLGLADGHQGLRGAVISSAQLLELAPQFAHALGIEVKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC64</accession>
    <name>A0A1E7NC64_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0022330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284104.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4204"/>
    <dbReference type="EnsemblBacteria" id="ARF80206">
        <property type="protein sequence ID" value="ARF80206"/>
        <property type="gene ID" value="B6264_15940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38277">
        <property type="protein sequence ID" value="OEV38277"/>
        <property type="gene ID" value="HS99_0022330"/>
    </dbReference>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21019" checksum="D894B769F29BE42E" modified="2017-01-18" version="1">MSTRLILATRNQHKVAELRAILGDAGLDVELVGADAYPEIPDVPETGVTFAENALLKAHALARATGLPAVADDSGLCVDVLNGAPGIFSARWSGKHGDDRANLDLLLAQLSDIAEPHRGAHFFCAAALALPDGTERVVEGRLLGTLRTTPAGDGGFGYDPILQPLGEARTCAELTADEKNAISHRGQAFRALAPVVKDLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC67</accession>
    <name>A0A1E7NC67_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4206"/>
    <dbReference type="EnsemblBacteria" id="OEV38275">
        <property type="protein sequence ID" value="OEV38275"/>
        <property type="gene ID" value="HS99_0022315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009470">
        <property type="entry name" value="Chi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06483">
        <property type="entry name" value="ChiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="38570" checksum="0F90AB6B8F1F6A6B" modified="2017-01-18" version="1">MWHAKNLEKGILPDYLAGYGVTDTALRGSYTRNYSNSLVAPWLWNDTKKVFLSTEDEQSVGAKADYIVDQGAGGAMIWELAGDYRWDTTANGGKGEYVPGSTLTSLMYDKFKAASPYGAARSTVPLPQQTLPIDVSFTNFALGDSNYPINPKLHIVNNSTLTLPGGTEFQFDYSNSAPGNAKDRAGFGLQVIRQDNPGPGNAGGLKGTYNRVSVKLPGWQSLAPGASVDMDFVYYLPVSTPSNWTVNVAGTLYGIKGDLTRGALDSGTPTPIPTPTQTPTPTPTGTPTGTPTPTPTGTPTGTPAPTPTPAPGTCTAAPGWDAGTTYATPTKVSWKGHYYQNKWWTKGDDPAAGGAWGVWSDLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC73</accession>
    <name>A0A1E7NC73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284073.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4188"/>
    <dbReference type="EnsemblBacteria" id="ARF80192">
        <property type="protein sequence ID" value="ARF80192"/>
        <property type="gene ID" value="B6264_15865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38290">
        <property type="protein sequence ID" value="OEV38290"/>
        <property type="gene ID" value="HS99_0022405"/>
    </dbReference>
    <dbReference type="OMA" id="KPMVMAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20125" checksum="8489CF6576511DE8" modified="2017-01-18" version="1">MAGLFESAGGGGAAIALDEVEASILRSLEVQMLELIGPGPGGDDGDDPLAALFAEGPSEAPADPALARLFPDAYGGPAAPQDEETRAAAAEFRRYTELDLRARKRDDALQVVRALDGLGGAGVLKLAAADCLHWLGALNDLRLTLGVRLEVSEEDEQGLYELPDGDERKPLVMAYLWLGALQESLLEAITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI6</accession>
    <name>A0A1E7NCI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0021020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386119.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene260"/>
    <dbReference type="EnsemblBacteria" id="ARF82214">
        <property type="protein sequence ID" value="ARF82214"/>
        <property type="gene ID" value="B6264_28035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38395">
        <property type="protein sequence ID" value="OEV38395"/>
        <property type="gene ID" value="HS99_0021020"/>
    </dbReference>
    <dbReference type="OMA" id="NAIQEDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="474" mass="50404" checksum="102773E5A8CE83D5" modified="2017-01-18" version="1">MTTEDFRSAARATADLVSDYLAELPARPVWQPMGDTARKTLLDAPLPAEGRPLGELLAAIERDVLPHPMGNGSPRFFGWVNSAPAPAGVLATLAAAAMNPSSAGGDHADIHLERAVVRWIAELVDFPHPPGGGLLTSGTSMATIVCLAAARNRAARRAGHDVREEGLAGLPPLIGYVTGETHSCVRKAAELLGLGSRHLRTVATGPDGRFDPVELGAAVERDRAAGLLPFLVVASAGTVGTGAVDEFGPIADLCEEQGLWLHVDGAYGAFGRLDPAIAHRYAGLERADSLALDPHKWLGVPVDCGCALVRDTDELRATFSLVPSYLRDEAAGALGWFSEYGTEQTRPFRALKVWATIAHRGRTGLARDIAHCTALARRLGELVEADDELELLAEVQTSIVAFRHRTTGLDGTELNALNRDLPVAVQRRGRVFVTGARFGGQEMLRACLLNAATTEEDLHLLLAEVKAAARTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCV8</accession>
    <name>A0A1E7NCV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000612.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3073"/>
    <dbReference type="EnsemblBacteria" id="OEV38484">
        <property type="protein sequence ID" value="OEV38484"/>
        <property type="gene ID" value="HS99_0021560"/>
    </dbReference>
    <dbReference type="OMA" id="WTGGWSN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PTHR31104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199008" evidence="2">
        <location>
            <begin position="39"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="559" mass="59982" checksum="DE7EEC8485BA993B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY7</accession>
    <name>A0A1E7NCY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3095"/>
    <dbReference type="EnsemblBacteria" id="OEV38541">
        <property type="protein sequence ID" value="OEV38541"/>
        <property type="gene ID" value="HS99_0021670"/>
    </dbReference>
    <dbReference type="OMA" id="VEDPGWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="44148" checksum="3F748392A17F4B3D" modified="2017-01-18" version="1">MEQGVSSGQLAPGTALPPLRDLAAELGVNPNTVAAAYRLLRDRGVIETAGRKGSRILPRPALTPRDLIRIPVPAQASDLSTGNPDPALLPDLGPALAAAAEALRAEPVLYGHPRIDAGLLDLARTSFEADGLHGPIAVASGALDTVERALGAWLRPGDAVAVEDPGWGSLLDLLPAMGLRPEPVRLDDQGLLPDSLAAALAEGARAVVVTSRAQNPTGAALTARRAAALRAVLAGHPGVLLIEDDHGHGMVDQPYHPLVGAGPRHWAVVRSAAKAYGPDLRVSVMVGDEETVGRVAGRLRLGAGWVSHLLQRTVAELWRTDAAPAASVAAAYRTRREALLGELAARGIEAHGVSGLNVWVPVPDETSALAALVQRGWVAAPGARYRIQSPPGLRFTAARLEAADARRLAEDLAEVLGSGGGGSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH1</accession>
    <name>A0A1E7NDH1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">HS99_0018960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7343"/>
    <dbReference type="EnsemblBacteria" id="OEV38756">
        <property type="protein sequence ID" value="OEV38756"/>
        <property type="gene ID" value="HS99_0018960"/>
    </dbReference>
    <dbReference type="OMA" id="WPRARRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="615" mass="62241" checksum="B696227AB263EC5C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV2</accession>
    <name>A0A1E7NDV2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0019410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557916.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6290"/>
    <dbReference type="EnsemblBacteria" id="ARF81238">
        <property type="protein sequence ID" value="ARF81238"/>
        <property type="gene ID" value="B6264_22145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38835">
        <property type="protein sequence ID" value="OEV38835"/>
        <property type="gene ID" value="HS99_0019410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="544" mass="56087" checksum="EFC0A7C90A6A925D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDY7</accession>
    <name>A0A1E7NDY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7390"/>
    <dbReference type="EnsemblBacteria" id="ARF81204">
        <property type="protein sequence ID" value="ARF81204"/>
        <property type="gene ID" value="B6264_21925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38921">
        <property type="protein sequence ID" value="OEV38921"/>
        <property type="gene ID" value="HS99_0019190"/>
    </dbReference>
    <dbReference type="OMA" id="MAIPQLS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11566" checksum="AC795BE1FEFE3494" modified="2017-01-18" version="1">MALPPLTPEQRTAALAKAAEARRERAEVKNRLKHSGASLHEVIKAGKNDNDVIGKMKVSALLESLPGVGKVRAKQIMERLGISESRRVRGLGTNQIASLEREFGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ2</accession>
    <name>A0A1E7NEQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4067"/>
    <dbReference type="EnsemblBacteria" id="ARF83384">
        <property type="protein sequence ID" value="ARF83384"/>
        <property type="gene ID" value="B6264_30765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39152">
        <property type="protein sequence ID" value="OEV39152"/>
        <property type="gene ID" value="HS99_0018475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="27234" checksum="41509D75DC2C71BE" modified="2017-01-18" version="1">MTYEGIRNWDEFDPARHPFPWDEDEETRLRELIREWVPPVLSGMAGWWQAEHWCERQVDAVIRERYGSWAWGWNWCYRHGGPVGSWVSGPSSVTTPDETATRAVAALLEWREWLERLAQRFTELAPPPHTCPEDRSWYLERACVRLVTHVLDSGAEAGWQGLASVVLTWFLTATGMGRAEAGQAVERAIGGRFKSWVNPGRTLIESVGEDLAADLTGHIPYPDHRQWADLEELHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW1</accession>
    <name>A0A1E7NEW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285265.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000221.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3564"/>
    <dbReference type="EnsemblBacteria" id="OEV39240">
        <property type="protein sequence ID" value="OEV39240"/>
        <property type="gene ID" value="HS99_0000505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199064" evidence="2">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6107" checksum="525184866624B9BF" modified="2017-01-18" version="1">MTWLRVLTALGILTLAAAALLVFARCTAPSRGEHAAGAAPPDVREDAEGSGLFPRMGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF64</accession>
    <name>A0A1E7NF64_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284889.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3656"/>
    <dbReference type="EnsemblBacteria" id="OEV39314">
        <property type="protein sequence ID" value="OEV39314"/>
        <property type="gene ID" value="HS99_0000950"/>
    </dbReference>
    <dbReference type="OMA" id="EEVTHSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="600" mass="67573" checksum="C6BC3FF50295556A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF95</accession>
    <name>A0A1E7NF95_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3646"/>
    <dbReference type="EnsemblBacteria" id="OEV39305">
        <property type="protein sequence ID" value="OEV39305"/>
        <property type="gene ID" value="HS99_0000905"/>
    </dbReference>
    <dbReference type="OMA" id="CPHYLGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="147"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="371" mass="40428" checksum="30F794491C5352C3" modified="2017-01-18" version="1">MTDPVQVDHLAVHAFTVPTDGPDGTEQDGTLEWDSTTMVLVEARGGGRTGIGYTYADVSTAVFAESKLVPLAVGADALAPPAVWQRMRRATRNAGQPGAGAMAVSAVDHALWDLKARLLELPVVDLLPSFHDRVPVYGSGGFTNYPLDRLADQLSGWAAQGIPRVKLKTSRHPDQDPERLRAVRRAVGDDTELFADANGALNRTEAVHWARRFAEEWDVRWFEEPVSSLNPRGLRTVREHTAGRPEITAGEYGYLLTDFATLLEADAVDCLQADITRCGGITGLLQVAGLAAAHDIDLSGHCAPALSAHGFCAVDRLRHLEYFHDHVRLEGMLLDGTLRPEGGALRPDRDRPGFGLDVRWADAERYRVHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA5</accession>
    <name>A0A1E7NFA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550264.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3657"/>
    <dbReference type="EnsemblBacteria" id="OEV39315">
        <property type="protein sequence ID" value="OEV39315"/>
        <property type="gene ID" value="HS99_0000955"/>
    </dbReference>
    <dbReference type="OMA" id="HDVHPEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17460" checksum="93E730C895461C9B" modified="2017-01-18" version="1">MAEGRLDAQAVEQRLARLDELLERVEAVPGPGGEAALAAVRTLTEVYGEALARVLDLVPPEPLLDDELLGHLLVLHDLHPEPPERRAARALQALRERGVQAELAGVDGGVAEVRLTVKGCGSSAGAVEAAVREAVLAAAPELSEVRRAPERAFVPVDSLLLPRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL0</accession>
    <name>A0A1E7NFL0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000137.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39273">
        <property type="protein sequence ID" value="OEV39273"/>
        <property type="gene ID" value="HS99_0000715"/>
    </dbReference>
    <dbReference type="OMA" id="PRIAIYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199092" evidence="1">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17827" checksum="2FFD08F56250AA56" modified="2017-01-18" version="1">MPLRTIPRRALVLTVAVLTALPIAVLTAPAQAASAPPTASAAAAAPVRFVDLPDTALPTDRAPHRITFMYRNDTPADQTIAPQILVESPQQGPFLSPSDVRLEQLGRDGRWHTLPLGSQTGTLYTQLIPAKIVLHSHHTLTENYRLTVLHAPARGTIEPRIAIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL5</accession>
    <name>A0A1E7NFL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285835.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5062"/>
    <dbReference type="EnsemblBacteria" id="OEV39500">
        <property type="protein sequence ID" value="OEV39500"/>
        <property type="gene ID" value="HS99_0002065"/>
    </dbReference>
    <dbReference type="OMA" id="VWNGFLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="36651" checksum="2E5FCBB1C73CB82A" modified="2017-01-18" version="1">MTTAPTTPGARAVTRYRLFWPAAVLAVLLLANLAFTPDFFAVHLKDGHLYGSTIDILHFGAPLILVSLGMTLVIATGGIDLSVGSTVAIAGALACLHISEAADPASLGTVLGAVGIALGTAVLLGLANGVLVARVGVQPIIATLILMVAGRGVAQLITDGQIITITSEPYKLIGGGYWLAMPFAILLSGLVALLTALLTRSTALGLLLESVGGNPVASRLVGIRAMRLVGLVYVFSALCAALAGLMVSSNVSAADGNNAGLWIELDAILAVVIGGTSLNGGRFSIGGTVLGALIIQTLSTTVYTIGIPPETTLVFKAFVVITVCLIQSPNFRAKLARRGAGRRAGVRPSPATTTNREVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFQ8</accession>
    <name>A0A1E7NFQ8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpB</name>
        <name evidence="8" type="ORF">HS99_0002310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6759"/>
    <dbReference type="EnsemblBacteria" id="OEV39539">
        <property type="protein sequence ID" value="OEV39539"/>
        <property type="gene ID" value="HS99_0002310"/>
    </dbReference>
    <dbReference type="OMA" id="GFKIKPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="7">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="6">
        <location>
            <begin position="134"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="48708" checksum="701AA99571DD9EF9" modified="2017-01-18" version="1">MRWSEVECTDVRELRGPLAVVGGVTGVGWDEFVRITLGSGERRHGLVLEVDRDLAVLQVLEGTAGIDPTAVRVAFASSPLRIPVGPGWLGRVCNGRGEPIDGGPPVFGAAEAEVGGTPINPVRRVPPSEPVLTGVGAIDVLTTLVRGQKLPIFSAAGLPHLELAVQIAAQSTAGGEEFSVVFAGMGLTHADASFVRGALAERSAAGELVLLLNTADDPVIERLLTPRLALTVAEHLAFDGGRHVLVVMTDMTAYAEALREVSAARGEIPARRAYPGYLYSDLASLYERCGRIRDRSGSVTVLPVLTMPAGDITHPVPDLTGYITEGQIVLTREAHARGVYPPVDALSSLSRLMRKGAGPGRTREDHLDVAAQLLAALARARQVRELADLIGRPALSPTDLRYLELDEAFQLGFLAQRPDENRPLDASLALAWEVLRTLPRGQLAMIPSELLDRHGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG12</accession>
    <name>A0A1E7NG12_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0003005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2795"/>
    <dbReference type="EnsemblBacteria" id="OEV39651">
        <property type="protein sequence ID" value="OEV39651"/>
        <property type="gene ID" value="HS99_0003005"/>
    </dbReference>
    <dbReference type="OMA" id="SNWQLQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="7">
        <location>
            <begin position="688"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="950" mass="105162" checksum="9EE5228D8FA841A4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD2</accession>
    <name>A0A1E7NGD2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480399.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2931"/>
    <dbReference type="EnsemblBacteria" id="OEV39760">
        <property type="protein sequence ID" value="OEV39760"/>
        <property type="gene ID" value="HS99_0003670"/>
    </dbReference>
    <dbReference type="OMA" id="HFIASGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="28471" checksum="23D2ECA0A2786EA0" modified="2017-01-18" version="1">MTAAGSSWVVRTEPNPAARLRLICFAHAGGGSSAFADWPRALPDDVEVCAVRLPGRESRIFQPAYTDVEDLLPDLTAPLADHCRPPYALFGHSMGALIAFSFARRLRELGAPAPDHLVVSGRRAPQLAHNRPLIHHLPQDQFLNRIRELGGTPESLLADARVMRLVLPGLRADFQLNDCYTHRPQEPLPVPITAFGGRADPHVDPEGLAAWARQSTGAFTMRMFDGGHFFLHSAQQEVLHELSRLLRRPTDRIAGAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI4</accession>
    <name>A0A1E7NGI4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387336.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000828.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39573">
        <property type="protein sequence ID" value="OEV39573"/>
        <property type="gene ID" value="HS99_0002520"/>
    </dbReference>
    <dbReference type="OMA" id="SLRTHWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="17185" checksum="F6496AE72C214CC2" modified="2017-01-18" version="1">MDSETPAPSDGLPPTLLELSTFLLARIGRTARGRLGEQLAERGLRLWDMAVLAALADFGPQAQRDLVRRLGIDPSDLAKVADQLGAAGYVERSRDRADRRRVSVSVTEAGRALLAELEARARAVQDEVLAPLDEGERRVLQGLLRRVNEGAALRRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK5</accession>
    <name>A0A1E7NGK5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0001825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5111"/>
    <dbReference type="EnsemblBacteria" id="OEV39824">
        <property type="protein sequence ID" value="OEV39824"/>
        <property type="gene ID" value="HS99_0001825"/>
    </dbReference>
    <dbReference type="OMA" id="AQVVIMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="8">
        <location>
            <begin position="573"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="711" mass="74893" checksum="63D34C44238A7C32" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP6</accession>
    <name>A0A1E7NGP6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DPBB_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2769"/>
    <dbReference type="EnsemblBacteria" id="OEV39852">
        <property type="protein sequence ID" value="OEV39852"/>
        <property type="gene ID" value="HS99_0002875"/>
    </dbReference>
    <dbReference type="OMA" id="ANWFSIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="SSF49590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199133" description="DPBB_1 domain-containing protein" evidence="2">
        <location>
            <begin position="45"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="3">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="33890" checksum="CB3679C7EEA59C41" modified="2017-01-18" version="1">MRATKHAVPRARRGRGLGMGGPLALVAVGLLVCVALGLTGVSGAGSGQPAGAAAGATAQSMPTTADGPDGATPSAVPPSPTAPSPSPTPSTGTASPSAPATSKPSVASKPSATATPSPSAAGSARTAAAAAAQAGRIEPGTSYQGVATSYDAADGNGACSFGPSGDLMIAAMNHTDYETSRACGAYVRVRTANGASVTVRIVNECPLPCAPGQLDLSHEAFAKLADLSVGRLPITWTLLSPGEPDGMSVRYKTGSSQWWCGIQVIGHRNPVAALEVRTAGGWRQLTRTDYNYFLSPDGGGCGGPIRVTDIYGEQLTVDGIALRPDVVQSTRVQFARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV14</accession>
    <name>A0A1E7MV14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550565.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000240.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2976"/>
    <dbReference type="EnsemblBacteria" id="OEV32270">
        <property type="protein sequence ID" value="OEV32270"/>
        <property type="gene ID" value="HS99_0016270"/>
    </dbReference>
    <dbReference type="OMA" id="RAGQWRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="35109" checksum="D724A22633FE8025" modified="2017-01-18" version="1">MESDYDDLDRRLVHALQVDGRAPFSTIAAVLGVSDRTVARRYARLRSTGAVRVLGGIDPTALGAVLWLLRVRCAPSAAVAVAEALARRPETAWVSLSSGGTEITCTVRAESEADSEALLLARLPRTPRVEGVSAHSVLHTFYGGPDSLIAKLGPLDAQAVEALRPAPPPHRPEPVGPLPDRPVRLDDGDRKLLAALAADGRAGFEQLAGLTGWSPTTVRRRMAELRERGVLYLDVDCDRRLLGAGTRTLLWLSVAPPHLEAAGRALAGHPEVAFAAATTGPTNLYATVVCADQRALYRYLTTRVAALPAVLQVETAPVIRTVKQAANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD6</accession>
    <name>A0A1E7MVD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553868.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000655.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32384">
        <property type="protein sequence ID" value="OEV32384"/>
        <property type="gene ID" value="HS99_0016955"/>
    </dbReference>
    <dbReference type="OMA" id="DTAHPYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="51762" checksum="EC03F17CEE00EF4A" modified="2017-01-18" version="1">MIDVIVVGGGPTGLMLAIELRLQGVQVVVLERLTEPTGESRGQGLHVRSVEMMDQRGLLDRFLAVGGKFKVGGFFGHIHKPWPETMDTAHPYGLTVEQPVTERLLHEYALDLGAEIRRGQEATGLSQDEDAVTVELADGTRLRSRYLVGCDGGRSTVRRQLGIAFPGEPSRVDTLLGELSLAEDPATIEAVVTEVRRTELRFGAIPRGEGAYRVIVPATDVAEDRAEAPTLEEFRQQLRAIAGTDFGAHSPRWLSRFGDATRQAEQYRLGRAFLAGDAAHIHPPTGGQGLNLGIQDAYNLGWKLAAAVRGHAPADLLDSYHAERHPVGARVLANTRAQMTLLGAEPGAVALRELLSTLMDFEEVNRYITEMVFGVGVRYDLGEGHELLGRRLRDVRLKQGRLYERMHGGRALLLDATGGSLSVAGWADRVDRVVDPLEELDAPAVLLRPDGHVAWVGAEQQSLNGALARWFGAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU4</accession>
    <name>A0A1E7MVU4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000095">
        <property type="protein sequence ID" value="OEV32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289923.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene103"/>
    <dbReference type="EnsemblBacteria" id="ARF82846">
        <property type="protein sequence ID" value="ARF82846"/>
        <property type="gene ID" value="B6264_15310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32545">
        <property type="protein sequence ID" value="OEV32545"/>
        <property type="gene ID" value="HS99_0040230"/>
    </dbReference>
    <dbReference type="OMA" id="PGGHRDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13780" checksum="097B0551F32BB0D4" modified="2017-01-18" version="1">MRIGELARRTGVSERSLRYYEQQGLLVARRTAGGHREYPEMAVDRVVHIQELFAAGLHSRTIYKILPCMRDSDGGPSETATPLLVEELTSERDRIDRMITDLLRSREVLDEVIAGATGRPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVY5</accession>
    <name>A0A1E7MVY5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553343.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3799"/>
    <dbReference type="EnsemblBacteria" id="ARF78378">
        <property type="protein sequence ID" value="ARF78378"/>
        <property type="gene ID" value="B6264_05090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32584">
        <property type="protein sequence ID" value="OEV32584"/>
        <property type="gene ID" value="HS99_0014990"/>
    </dbReference>
    <dbReference type="OMA" id="APWWRDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="18535" checksum="9BC117A425AD98D3" modified="2017-01-18" version="1">MSFLERLRATPATVDYLLWPGDFSLDAYSHVEEVVLASGERLEEVAKCGAGGTFFLCGEGGDERPVLYADSEGGAALLAVGLEEMVRLVLAVPWWRDCVRLTEEESAEAAEDHLAEEPDLLADRDAAAAAIGLEVPTAAEALARLREVVVGLGASYVLLNAVEGNAYEPIFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW04</accession>
    <name>A0A1E7MW04_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0015180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366545.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3836"/>
    <dbReference type="EnsemblBacteria" id="OEV32617">
        <property type="protein sequence ID" value="OEV32617"/>
        <property type="gene ID" value="HS99_0015180"/>
    </dbReference>
    <dbReference type="OMA" id="FGVSRIW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34648" checksum="F163F2A73195FC73" modified="2017-01-18" version="1">MAELKPYPKIPARGRSGAPGSREWTAAEKVHGAHFAVVCQDPSVRPAKRRDLLADEELDAFFGVSRIWPQLLVAARRFAAALRATRGESAVVTVYGELAGGRYPHPGVPAVPGAEPVQTGVWYAPGLRWLPFDATVETAAGRCWIADRELRSAASAAGLTCVPLLGHGALKTLQELPVAFPSRVPALLGLPELPDNLAEGYVLKPAGEWHESDAARPVVKVKQRAFAEDDRYDGARPYLPPPEGAAGVPAWLLVQASAFLTPARAAAAVSKLGPRAGTDAVAAEVAHDVADELSEALGGLEPSTLTALRHALRPATLSLAAFDAADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM2</accession>
    <name>A0A1E7MWM2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000084">
        <property type="protein sequence ID" value="OEV32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32828">
        <property type="protein sequence ID" value="OEV32828"/>
        <property type="gene ID" value="HS99_0039920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16869" checksum="EFFEBBA7427F0A6E" modified="2017-01-18" version="1">MRCDTTASMDYVEEQFSAIVAQLFSTVQVVEPVPCEAPPERYETAESISRAMSDIRAEKDMGLYEYEGGHGEYLQRINSLAERRKSVAQALQPKPRALRPTGSTFASQWDDSDVASRRRLLLKSKVKAYVAKNTLSFLFPDDLEKELTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY1</accession>
    <name>A0A1E7MWY1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552557.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81348">
        <property type="protein sequence ID" value="ARF81348"/>
        <property type="gene ID" value="B6264_22740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32938">
        <property type="protein sequence ID" value="OEV32938"/>
        <property type="gene ID" value="HS99_0013720"/>
    </dbReference>
    <dbReference type="OMA" id="QHPGKGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="18258" checksum="95D34D1C89A6B62E" modified="2017-01-18" version="1">MAPGTSDGKAWTRWLLGVFLTACVLVTVGCVWWGVVEMRRSFDRPETDYDRAERLAGLHYKQHPGKGRYYIPTAAALSRAADGSPVAYLHFGIAGGDSANIDDFLHTYDLPRPGSVAPLPQDLRAALSGDEPAEGLLLPVGQAGRQIFVVMRPCDVEGAGDVYVRATGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX83</accession>
    <name>A0A1E7MX83_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbpA</name>
        <name evidence="2" type="ORF">HS99_0014360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279777.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5648"/>
    <dbReference type="EnsemblBacteria" id="ARF81462">
        <property type="protein sequence ID" value="ARF81462"/>
        <property type="gene ID" value="B6264_23390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33048">
        <property type="protein sequence ID" value="OEV33048"/>
        <property type="gene ID" value="HS99_0014360"/>
    </dbReference>
    <dbReference type="OMA" id="VWECRCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="14184" checksum="52497169FD80AFFF" modified="2017-01-18" version="1">MSERALRGTRLGATSYETDRGIDLAPRQTVEYACQNGHRFEVPFSVEAEIPPVWECRFCGQEAALLDGDEPEEKKVKPTRTHWDMLMERRTREELEEVLAERLAVLRSGGMNLAVHPRDTRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL9</accession>
    <name>A0A1E7MXL9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="7" type="ORF">HS99_0014000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552492.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5720"/>
    <dbReference type="EnsemblBacteria" id="ARF83010">
        <property type="protein sequence ID" value="ARF83010"/>
        <property type="gene ID" value="B6264_23030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33151">
        <property type="protein sequence ID" value="OEV33151"/>
        <property type="gene ID" value="HS99_0014000"/>
    </dbReference>
    <dbReference type="OMA" id="ANRMEHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="35087" checksum="0C652E33F411F333" modified="2017-01-18" version="1">MVLGIESSCDETGAGLVRGGVLLGQAVASSMDEHARYRGVVPEIAARAHVHAVAPVVRVALDRAGLALADVGAVAVTTGPGLAGALQVGVAAAKAYAFSLGVPLYGVHHLAGHVAAATLDGGPLPDPCVVLIVSGGHTSLLLVRDLARDPILHLGDTLDDAAGECFDKVARILGLPYPGGPAIDRAARTGDPTAVRLPRPLTGPRDDPYAFSFSGLKTAAARWVEAQPEPHVPDAAAALQEAVADVLTRKAVRACTDHGIGTLVVVGGVAANSRLRALAEQRCAAAGITLRVPPLRLCTDNGAMVAAIGDLLVRSGAEPAPARLSVDPSAPLEFAALSPVPVPAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR2</accession>
    <name>A0A1E7MXR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366920.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5678"/>
    <dbReference type="EnsemblBacteria" id="ARF81439">
        <property type="protein sequence ID" value="ARF81439"/>
        <property type="gene ID" value="B6264_23240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33023">
        <property type="protein sequence ID" value="OEV33023"/>
        <property type="gene ID" value="HS99_0014210"/>
    </dbReference>
    <dbReference type="OMA" id="WFDVIDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1226" mass="132629" checksum="F0E364D53B7E3AE7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXW9</accession>
    <name>A0A1E7MXW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291321.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000170_gene544"/>
    <dbReference type="EnsemblBacteria" id="ARF78584">
        <property type="protein sequence ID" value="ARF78584"/>
        <property type="gene ID" value="B6264_06370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33288">
        <property type="protein sequence ID" value="OEV33288"/>
        <property type="gene ID" value="HS99_0038885"/>
    </dbReference>
    <dbReference type="OMA" id="AMCRQVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14610" checksum="63633F13259CE042" modified="2017-01-18" version="1">MTPPSTPAGPYGNGYGSGYGGQQSDGYEQQPLVRPYAMTGGRTRPRYQLAIEALISTTGSAERTTGLLPEHARIVNLCREVKSIAEISALAGVPLGVARILVADLAEAGLVAIHQPAAAGESGGTPDVTLLERVLSGLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR2</accession>
    <name>A0A1E7MYR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386013.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3974"/>
    <dbReference type="EnsemblBacteria" id="ARF82893">
        <property type="protein sequence ID" value="ARF82893"/>
        <property type="gene ID" value="B6264_17805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33590">
        <property type="protein sequence ID" value="OEV33590"/>
        <property type="gene ID" value="HS99_0012580"/>
    </dbReference>
    <dbReference type="OMA" id="AFTEWFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="43165" checksum="0E4BD25643A55B6D" modified="2017-01-18" version="1">MTAQERRNAAERAERRAATLKRLEKSSGKLATAAIARMDDQLGWYRRMPPEHRSWIGLVAQAGIAAFTEWYRHPEAARAISTDVFGTAPRELTRAITLRQTVELIRTTIEVMEEAIEEVAAPGDEADMRESVLVYAREIAFATAQVYAQAAEARGAWDARLEALVVNSLLSGDADEGVLSRAAALGWGQPSQVRVVMGSAPDGDSELVVEAIRRAARYAKLNVLTGVLGKRLVVVVGGDKEPVHAARALIGQFAPGPVVIGPTVPDLLSATRSAHAAAAGLRACAAWPDAPRPVLADDLLPERALAGDQAARRQLVEEIYTPLDEAGSALLETLSVYLEQASSLEGAARMLFVHPNTVRYRLRRVTDVTGYAPSDVRSAFTLRIALALGRLTSAAEPGRAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX8</accession>
    <name>A0A1E7MYX8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552324.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1100"/>
    <dbReference type="EnsemblBacteria" id="ARF78984">
        <property type="protein sequence ID" value="ARF78984"/>
        <property type="gene ID" value="B6264_08695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33636">
        <property type="protein sequence ID" value="OEV33636"/>
        <property type="gene ID" value="HS99_0038530"/>
    </dbReference>
    <dbReference type="OMA" id="CNTAFIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="583" mass="58528" checksum="B2791EF7A0C49070" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ81</accession>
    <name>A0A1E7MZ81_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549948.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5213"/>
    <dbReference type="EnsemblBacteria" id="ARF80636">
        <property type="protein sequence ID" value="ARF80636"/>
        <property type="gene ID" value="B6264_18545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33533">
        <property type="protein sequence ID" value="OEV33533"/>
        <property type="gene ID" value="HS99_0013325"/>
    </dbReference>
    <dbReference type="OMA" id="LCHDHAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="39009" checksum="899012CF1DBBE50D" modified="2017-01-18" version="1">MIERLPKFPWDVLFPYRRRAAAHLDGLVNLALGDPVDPTPEAVRAALAAAADAPGYPSTEGTPALRAAAAAWLLRREGVSVEPEAVIPAVGTKELIAWLPTMLGLGPGDVVLAPQLSFPTYEVSARLAGATFVRTDDPLSYDGPAPRLLWLNSPSNPEGRVLDAAELRAVVEWARERGTLVVNDECYLDHVWERSTRSVLHAEVTGGDHHGVLAVHSLSKRFNLAGYRAGFAAGDPAVIATLLEVRKHAGHMVPAPVQAAMVAALGDDAHLAAQRQRYARRRELLRGALVDAGFRIEHSAGALFLWATRDEPCWTTVGALADRGILVAPGEFYGAAAARHVRVAVTETDERVEQAVKRLAEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ9</accession>
    <name>A0A1E7MZJ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282198.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6367"/>
    <dbReference type="EnsemblBacteria" id="ARF78758">
        <property type="protein sequence ID" value="ARF78758"/>
        <property type="gene ID" value="B6264_07360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33865">
        <property type="protein sequence ID" value="OEV33865"/>
        <property type="gene ID" value="HS99_0037285"/>
    </dbReference>
    <dbReference type="OMA" id="WYAAMSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="45239" checksum="7149EE3A5C866F24" modified="2017-01-18" version="1">MALAVGLTACSSSGSPSGDKSAAADPKAATGTVTVWLMDDAQKNWPDLVQRVNDEFAAKYPGVNLKLVYQGWADKVGKLDKALADGSAPDVVELGNTETMKYVLSGALAPVDRTTFDNSDSWIKALANTCTYQDKLWCVPYYAGARVAIYNSSAFQQATGSTEFPRTENDLLTALDKISDRNRSDRTFSPLYLPGPYWYAAMSYVAAYGGSIAKFDSSGNWHGTLHDAKSQQGIGHFVDLVRKYNKGDLTQNEQDQYVAMARGHAASFYGNGFEAAGVTAPGTGDPGLKDAVKVATMPGPDGKPLPTFIGGSDLAVTAKSKQLAPATDWIRMFTSSRSEQALADKDILPNNLNQLNPLKNKPTTAAAANAVPDAWFTPLAPGWGAVEKQKIIPDMLTAILKGKPVDQATKDADAAIDQLINNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR7</accession>
    <name>A0A1E7MZR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283134.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000288.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77777">
        <property type="protein sequence ID" value="ARF77777"/>
        <property type="gene ID" value="B6264_01510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33929">
        <property type="protein sequence ID" value="OEV33929"/>
        <property type="gene ID" value="HS99_0010670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13027" checksum="08F7214D174E5538" modified="2017-01-18" version="1">MRGCITRKIATFGMAAAAALGMLGTATLPAAAAPADDQTITPSAAAASPHVAAAPYHCVITANYGWRWEGYCNVYSGQLRTITYCANGSYTVGLWIGARPDAWAVWGNCPGSTWTKIVFQWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N028</accession>
    <name>A0A1E7N028_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">HS99_0037730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4494"/>
    <dbReference type="EnsemblBacteria" id="ARF82878">
        <property type="protein sequence ID" value="ARF82878"/>
        <property type="gene ID" value="B6264_17105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33823">
        <property type="protein sequence ID" value="OEV33823"/>
        <property type="gene ID" value="HS99_0037730"/>
    </dbReference>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21881" checksum="DDFFD27F544FAD3C" modified="2017-01-18" version="1">MPGPMAPHAAAGDVLGGLGDQVYNRLLNERIIFLGQQVDDDIANKITAQLLLLAADPEKDIFLYINSPGGSISAGMAIYDTMQYIKNDVVTIAMGMAASMGQFLLTAGAKGKRFSLPNANILMHQPSAGLGGSATDIRIQAEQLLRTKKRMSELIAFHSGQSFEQITRDSDRDRWFTPEEALEYGLIDAIMHSAADVPGGGGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N042</accession>
    <name>A0A1E7N042_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2311"/>
    <dbReference type="EnsemblBacteria" id="ARF77916">
        <property type="protein sequence ID" value="ARF77916"/>
        <property type="gene ID" value="B6264_02355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34059">
        <property type="protein sequence ID" value="OEV34059"/>
        <property type="gene ID" value="HS99_0011505"/>
    </dbReference>
    <dbReference type="OMA" id="FVARPHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="46065" checksum="C7B65192A2E5D761" modified="2017-01-18" version="1">MRGGAVAVVGGSIAGSAFAGAAARLGAERVVVLERSPGRLEDRGLGICTHNDRFAELVDAGHLAPDTRRHRLTVRSWVTRAPAGRGDGDGGTRGRGRLLWAQPFPFHSHHWAVLWQALRESAPAAVEYRLGSTVTAVGDEGGASEAGGNEGGGNESGASAGAWIEEADGTRTPYDLVIGADGYRSVVRAAVCPQAVPEYAGYVCWRGSFDSALLAELPGGAGVWPEEECITVCYRGGQVVIYRIPGLTPGTTQVNWVFYAPTPDWLRLDGPTAVAAGALSDQQLDGMREFAERQLPSYWAGVIALTPRERTLLQPVYDLATPHRTAGRLLIGGDAATVVRPHNTSGAVKALQDAHAFEQAGRRLGGGSWSPLLAAYDRERTAAGLELVNLGRTLGRAQVTGAPDWSVMDEASMAAWWREQLTGSGGFGGHALRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N076</accession>
    <name>A0A1E7N076_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2324"/>
    <dbReference type="EnsemblBacteria" id="ARF77929">
        <property type="protein sequence ID" value="ARF77929"/>
        <property type="gene ID" value="B6264_02420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34071">
        <property type="protein sequence ID" value="OEV34071"/>
        <property type="gene ID" value="HS99_0011570"/>
    </dbReference>
    <dbReference type="OMA" id="ARHLVCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="313" mass="33843" checksum="DA189B861C95E2A7" modified="2017-01-18" version="1">MDIGVFLPTGQSQWQPAGDPRDLIGFARRAEQLGFASLFVNDSLLTPRIEPLTMLAAVAPVTERIRLGTGALLPVLRRPVQAAQALASVDLLSGGRLTVAVGAGFPGRFGQPLHELSQVPWERRFARLDETVALWRELWAGATEFHGEFHDFPELPSTTRPFALPGPPVWLGGATPAALARTGRHYDGWLPYPPDPADYATGLAAVRRAAHGAGRAPEAVTPALFVNVRIDEDPEAARRTMDAYARSNYGLPLEEVARIQAIAMGTPAQVAATLRGYTEAGAEHVVARLGALDLDGQYEQLERLAELTRPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N099</accession>
    <name>A0A1E7N099_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289989.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77965">
        <property type="protein sequence ID" value="ARF77965"/>
        <property type="gene ID" value="B6264_02620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34105">
        <property type="protein sequence ID" value="OEV34105"/>
        <property type="gene ID" value="HS99_0011765"/>
    </dbReference>
    <dbReference type="OMA" id="EFAIAWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="37590" checksum="08001416AA3B0E06" modified="2017-01-18" version="1">MRYRSLGRTGIKVSPYALGAMMFGALGNPDHDDCVRIIHRALDAGINLVDTADRYAHGESEEIVGRALKGRRADVVLATKARSPMSDEPNHQGASRRWLVRALEDSLRRLDTDYVDVYQIHRPDPDTDIEETLAALTDLQRAGKIRTFGTSALPASDIVRAHWVAERRGLARPRTEQPVYSILNRGIECEVLPVAQEFGMGTLVWSPLGGGLLTGRYRKGRAAATHRSRYGFRHLADDRRLDVVEQLIPLAEEAGLPLTHLAMGFVLAHPGVTSALLGPRTMEHLEDLLAGVDVALTDDVLDRIDAIVPPGTDTGTLDMAYQPPALQRPELRRRPSGERAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q2</accession>
    <name>A0A1E7N0Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554601.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6078"/>
    <dbReference type="EnsemblBacteria" id="ARF78167">
        <property type="protein sequence ID" value="ARF78167"/>
        <property type="gene ID" value="B6264_03875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34251">
        <property type="protein sequence ID" value="OEV34251"/>
        <property type="gene ID" value="HS99_0036975"/>
    </dbReference>
    <dbReference type="OMA" id="GDIGARC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12088" checksum="F6A144C62FD5ADD8" modified="2017-01-18" version="1">MGTSVPAPAPAPGTARRGRLRVADRVYARIAGKAAREVLAEAWAGRSVRGAPPRVTVARPGSTVTVRVAVDAPFPADLAGLARAVRERVATRVVGLTGTRVSEVVVEVEKLVAGGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R8</accession>
    <name>A0A1E7N0R8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PAS domain S-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1891"/>
    <dbReference type="EnsemblBacteria" id="OEV34287">
        <property type="protein sequence ID" value="OEV34287"/>
        <property type="gene ID" value="HS99_0036510"/>
    </dbReference>
    <dbReference type="OMA" id="RYGSARM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="297"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="461"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="630"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="853" mass="91414" checksum="DCB15B848D5AD110" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0X1</accession>
    <name>A0A1E7N0X1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="11" type="ORF">HS99_0036465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551357.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6424"/>
    <dbReference type="EnsemblBacteria" id="ARF78710">
        <property type="protein sequence ID" value="ARF78710"/>
        <property type="gene ID" value="B6264_07070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34340">
        <property type="protein sequence ID" value="OEV34340"/>
        <property type="gene ID" value="HS99_0036465"/>
    </dbReference>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="551" mass="60043" checksum="D820490C94868171" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N101</accession>
    <name>A0A1E7N101_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">HS99_0036470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551359.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6425"/>
    <dbReference type="EnsemblBacteria" id="ARF78709">
        <property type="protein sequence ID" value="ARF78709"/>
        <property type="gene ID" value="B6264_07065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34341">
        <property type="protein sequence ID" value="OEV34341"/>
        <property type="gene ID" value="HS99_0036470"/>
    </dbReference>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="332"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="49370" checksum="4F72180C73018EB1" modified="2017-01-18" version="1">MSRSAHPAGPRHGDVLPEGHYQAPPADLNALDPKVWSCTVARNAEGAATVGGIDVRRLAAEFGTPAYVLDEEDFRARARAWRDAFGAGADVYYAGKAFLSKAIVRWLHEEALNLDVCSVGELAVALAAGMPPERIALHGNNKSADELEHAVKTGVGHIVVDSYEEIERLAAIAARHGVRQQVLIRVTVGVEAHTHEFIATAHEDQKFGLSLNGGAAAEAVRRVLGHDSLELRGIHSHIGSQIFDMAGFEVAARRVVGLLAGIRDEHGVELPEIDLGGGLGIAYTSEDDPREPAEIAAALAEIVRRECAAANLNAPRLSVEPGRAIVGPTAFTLYEVGTVKPLEGLRTYVSVDGGMSDNIRTALYDAEYSVALVSRTSEAAPMLVRVVGKHCESGDIVVRDAFLPSDLAPGDLIAVPATGAYCRSMASNYNHALRPPVLAVRDGAARVIVRRETEEDLLRLDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1C1</accession>
    <name>A0A1E7N1C1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asp_Arg_Hydrox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2604"/>
    <dbReference type="EnsemblBacteria" id="OEV34263">
        <property type="protein sequence ID" value="OEV34263"/>
        <property type="gene ID" value="HS99_0036670"/>
    </dbReference>
    <dbReference type="OMA" id="HIPEHRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018193">
        <property type="term" value="P:peptidyl-amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asp_Arg_Hydrox" evidence="1">
        <location>
            <begin position="70"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="28122" checksum="283735802AD83C3A" modified="2017-01-18" version="1">MDVQSVMMELHGALGTEGLERVEECLRILTGEQAPEYLHEDQEPTRLFFPGISALPWHDTAELPWVARVEESYEAIKAEFLALREEQARFAPYEDLYTKELGWQGWDTYQLYRNGEWRDEVRERCPETHAAVSATPHGPRDGMFTILNPGVHITPHTGGVNLLLTAHLPLIVPPGCAIKVADDERGWEEGKVILFDDSFIHEAWNKGTQQRAVLLWDVWHPELTPVEVRALEILMPRFQRYLMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N223</accession>
    <name>A0A1E7N223_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366115.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4620"/>
    <dbReference type="EnsemblBacteria" id="ARF81901">
        <property type="protein sequence ID" value="ARF81901"/>
        <property type="gene ID" value="B6264_26125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34737">
        <property type="protein sequence ID" value="OEV34737"/>
        <property type="gene ID" value="HS99_0009645"/>
    </dbReference>
    <dbReference type="OMA" id="AITIFAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="13700" checksum="EC81A1219A6DFC24" modified="2017-01-18" version="1">MLGWWEAAACGAGGGLIAEAVVTYGRLKTWQQARHAARATAAPLPRLVVFVDPLADSIAALLRVLLGGAAGWLLHVQITGVYAAVAVGASAPALLAQVGRAATPTEALRGPDSGEADTPPPNDTEAARPRSGEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N225</accession>
    <name>A0A1E7N225_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555892.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4626"/>
    <dbReference type="EnsemblBacteria" id="ARF81906">
        <property type="protein sequence ID" value="ARF81906"/>
        <property type="gene ID" value="B6264_26160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34732">
        <property type="protein sequence ID" value="OEV34732"/>
        <property type="gene ID" value="HS99_0009615"/>
    </dbReference>
    <dbReference type="OMA" id="ITHRFPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="531" mass="57496" checksum="892B09F73A5AEEE7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N286</accession>
    <name>A0A1E7N286_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3210"/>
    <dbReference type="EnsemblBacteria" id="ARF81821">
        <property type="protein sequence ID" value="ARF81821"/>
        <property type="gene ID" value="B6264_25610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34820">
        <property type="protein sequence ID" value="OEV34820"/>
        <property type="gene ID" value="HS99_0010135"/>
    </dbReference>
    <dbReference type="OMA" id="QVTYYFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16914">
        <property type="entry name" value="TetR_C_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23493" checksum="2793A245763A3721" modified="2017-01-18" version="1">MEKKRTEDRSTSARSRDRGRATRRRLIEATARLCKERPGAEVSVAEIANAAGVFPNQVTYHFGSKDSLLVHAAFLGLLHDARRIERIGRQAPDAAAFRRNIARAVLAMPSLPSVTRALAAGISRPELASVVDQHLQLLFRQSERFVSQLIDSRGWRTRRPLNVEARTFWSTALGAVLLVRAGAHGTADDLDLAGALTIHDEPDPGDVAGTRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2C0</accession>
    <name>A0A1E7N2C0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556943.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3203"/>
    <dbReference type="EnsemblBacteria" id="ARF81815">
        <property type="protein sequence ID" value="ARF81815"/>
        <property type="gene ID" value="B6264_25560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34825">
        <property type="protein sequence ID" value="OEV34825"/>
        <property type="gene ID" value="HS99_0010165"/>
    </dbReference>
    <dbReference type="OMA" id="EMGGFQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="23321" checksum="026BA9A1CBAAEC20" modified="2017-01-18" version="1">MRAVIAEDSVLLRVGLTKVLEMGGFQVPAEVGDAEGLLAAVAEHRPELALIDVRMPPDFTDEGVRAAMEIRRRWPGTAVVLLSQYVEERYAADLLSANTSGVGYLLKQRVADVADFVAAVRRVADGGTALDPQVVAQLLLRRDNDPLARLTPREREVLGLMAEGRSNAGIAQALVVSESAVAKHINNIFAKLDLPVVDADHRRVLAVLRFLGASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L9</accession>
    <name>A0A1E7N2L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hyaluronate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033354918.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5856"/>
    <dbReference type="EnsemblBacteria" id="ARF82522">
        <property type="protein sequence ID" value="ARF82522"/>
        <property type="gene ID" value="B6264_00200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34941">
        <property type="protein sequence ID" value="OEV34941"/>
        <property type="gene ID" value="HS99_0034900"/>
    </dbReference>
    <dbReference type="OMA" id="GEWAVRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42125" checksum="FDD65DB2DC18CC46" modified="2017-01-18" version="1">MPPDGVWDVVVVGAGPAGASAAYAAAAQGRRVLLLDKAEHPRYKTCGGGIIGPSRDSLPPNFELPLQDRVSAVTFAYDGRYTRTRRARRMLFGLVNRDEFDLRLVQAAKQAGAVLVTGVTVTGVEQRGGEHRTALVTAADGRSFEARAVVGADGSASRIARHVGVTFDQIDLGLEAEIPVPPQVAADWSGRIHLDWGPLPGSYGWVFPKTETSSLTVGVISARGDGERTKQYLADYIRRLGLSGFAPRVESGHLTRCRAEDSPLSRGRVLVAGDAAGLLEPWTREGISYALRSGRLAGEWAVRVAEAGDAASVRREALNYAFAVKAGLGVEMRAGKQLLGAFERRPYLFHAAVCLVPAAWRAFARTTQGHTTFAQLLRQNRAARKLMAMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U0</accession>
    <name>A0A1E7N2U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35019">
        <property type="protein sequence ID" value="OEV35019"/>
        <property type="gene ID" value="HS99_0034345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7610" checksum="965FBB42C29FE851" modified="2017-01-18" version="1">MAQLAGPSVDYHARLEQRRGPQPSPQLLAAPARALRLSENELDHLYHLAGHEPPRRHGPLTRAAPRGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U1</accession>
    <name>A0A1E7N2U1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0034265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387508.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000982.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000130_gene3385"/>
    <dbReference type="EnsemblBacteria" id="OEV35004">
        <property type="protein sequence ID" value="OEV35004"/>
        <property type="gene ID" value="HS99_0034265"/>
    </dbReference>
    <dbReference type="OMA" id="TFEPHEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="34435" checksum="4825E35203F972E8" modified="2017-01-18" version="1">MAGSAGSADVAQAAQAAGYRPLLFSIAYGMTGSVGDAEDLVQDTFLNLARAEQAGTTVTNLKAYLTTSVTRLGINHLGSARVRRETYVGEWLPEPVVAFAERPGDTPAEHAELADSLSMAFLVMLEALSPVERAVFLLREAFGYGYPQLAQLTGKSEANCRQILTRARKHLAATTGDTPPPPPARRAQGDELARRFFEVAAGGDPQELLGMLAPDVVLHGDGGGKARAIGRRVTTPLPVAKLIVSAVRRTTELGARLVPARVNGHPGMVAYDAQGRVLNVLALDITQDGTVREIHAVANPDKLAHLGEVSDLGLRTPRKRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3D0</accession>
    <name>A0A1E7N3D0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289436.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1378"/>
    <dbReference type="EnsemblBacteria" id="ARF79269">
        <property type="protein sequence ID" value="ARF79269"/>
        <property type="gene ID" value="B6264_10375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35209">
        <property type="protein sequence ID" value="OEV35209"/>
        <property type="gene ID" value="HS99_0033345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6380" checksum="8BF3104D46A2AE26" modified="2017-01-18" version="1">MHPKVKIFITIFCYISAVAGLVTAVMDASQKPADTTSAVVAGVLGVAFLLGGLALTRKPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3D5</accession>
    <name>A0A1E7N3D5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385445.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1394"/>
    <dbReference type="EnsemblBacteria" id="ARF79255">
        <property type="protein sequence ID" value="ARF79255"/>
        <property type="gene ID" value="B6264_10300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35196">
        <property type="protein sequence ID" value="OEV35196"/>
        <property type="gene ID" value="HS99_0033270"/>
    </dbReference>
    <dbReference type="OMA" id="CACVVIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022514">
        <property type="entry name" value="NHPM_micro_ABC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03796">
        <property type="entry name" value="NHLM_micro_ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="547"/>
            <end position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="755" mass="81759" checksum="2D660C2F21F0303C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J9</accession>
    <name>A0A1E7N3J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-diaminopropionate biosynthesis protein SbnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289514.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6133"/>
    <dbReference type="EnsemblBacteria" id="ARF79308">
        <property type="protein sequence ID" value="ARF79308"/>
        <property type="gene ID" value="B6264_10610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35245">
        <property type="protein sequence ID" value="OEV35245"/>
        <property type="gene ID" value="HS99_0033575"/>
    </dbReference>
    <dbReference type="OMA" id="PVMGLKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023866">
        <property type="entry name" value="SbnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03944">
        <property type="entry name" value="dehyd_SbnB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="35518" checksum="CB65DF7C5A786738" modified="2017-01-18" version="1">MFEFRVIDGTTAREVIAGARPRIVQEVRETYLTHGAGESVNPDSYFLRFPAKPDARIIALPAYLGGSVGLAGIKWISSFPANIERGFPRASAALLLNDYETGYPFAVLEASQISAARTAASAVLAAEVLSGGRTAGRLAVVGAGIIARNILEFFGAQEWAIDELVVHDREATYAQALVDHADAQLGYPARVVEDLGEALKGADVVVLATTAGEPYILDPETFTPGQLVLNISLRDLAPEIIGGAYNVLDDVEHCMKANTSPHLAEQLYGNREFVTGTLAQVIEGEVAVGTDRPVVFSPFGLGVLDLAVGALVHAEAVAAGKATEIPGFFAETTRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T7</accession>
    <name>A0A1E7N3T7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HS99_0032530</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550632.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2433"/>
    <dbReference type="EnsemblBacteria" id="OEV35347">
        <property type="protein sequence ID" value="OEV35347"/>
        <property type="gene ID" value="HS99_0032530"/>
    </dbReference>
    <dbReference type="OMA" id="EPYPYRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="13 14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="16">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="194"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="distal binding residue" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OEV35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="425" mass="46728" checksum="9031AD8A9D2248FE" modified="2017-01-18" version="1">MDNSRTADAATATAEYDRLIARHHAMRLRRQLLTPAGPSEAAPGADPGSAGHEGYDGSVDQQVIRRDLDLVAPLSELIDHLYAVMFRRRPYLRALFPASMEFQQSHLERVLQHLVDHLHRPAELARTLRQLGRDHRKLGVRPVHYEAFEEALCAAIRHRAGEHWTDGLEAAWVRMLRFAVGAMVAGADSALAEPPYWHAVVTGHERRRPDLAVLRVRTGEPYPYRAGQYGTVEHPALPHTWRQYSIGCAPRGGNELEFHVRRTGPGGVSAALVERTAVGDRLRLGPPRGGLLPEGDGRGGSRDLLLVAGGTGLAPMKAIVEQQVLHRPPGRRVHLFVGARDRADLYDWSALAELGLHKPWLAITPVTVGRLADTVAAAGDWREHLACVSGPAGMVASVRSELLTAGLPSARVRYDQVLSRWSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N420</accession>
    <name>A0A1E7N420_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylglycinamide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385496.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1619"/>
    <dbReference type="EnsemblBacteria" id="OEV35441">
        <property type="protein sequence ID" value="OEV35441"/>
        <property type="gene ID" value="HS99_0032290"/>
    </dbReference>
    <dbReference type="OMA" id="DIAERAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="122"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="428" mass="44786" checksum="BE6225C13FF278B8" modified="2017-01-18" version="1">MKPPHEHPAGTSPLLVLISTGPQKYREYLLASISTRYRIHLVNTTEPSWESPYLVGSTVVPTTDLEHVSAAAAAVAAREPVHGVLSWDEARVHQAAAVAAGLGLPTTDADAVWRCRDKHQTRAALAAADLPQPGFALVGGAAEALAAADRIGYPVVVKPRAAAASYGVSLVRSAEAMTACFDFAAEATVPHMPDYDQAVLVEEYLDGPEVSVDSVIVDGKVRPLFVGHKRTGFPPYFEETGHTVSHDDPLLADPEFLDVLQDVHTALGFTTGWTHTELKLSPSGAAKVIEVNARLGGDLIPYLGRLASGIDPGLVAAAVACGREPDLTADRNLVGAVRFLYVEHDDTVIDRVEFDASALPPQIDRTVVLAAPGDVVSPPPRGLLTGRVALATAVAPTAAECETALDAAAAALRIVERAADGRAGGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H4</accession>
    <name>A0A1E7N4H4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366828.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5382"/>
    <dbReference type="EnsemblBacteria" id="OEV35589">
        <property type="protein sequence ID" value="OEV35589"/>
        <property type="gene ID" value="HS99_0006620"/>
    </dbReference>
    <dbReference type="OMA" id="WVVYLKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="25901" checksum="F0EB157D1B055701" modified="2017-01-18" version="1">MTVPNTPPEPARADAAAEPGAAPDPFAPPPVSDGEPPAGLPAAPPAAQHPLPAELRIGSGVVLACLLLGLVMAGLWAWLAPKVPLVVDGDRILYVDPEGEQRAGADAVFVLIGLGAGILTALGAFLLTRKRGGGISVALGLAIGGLLGSIGAWKLGRWLGPSDNLIAEARRVGNGGHFDAGIDLGALGALLVWPMAAMVVLLALSAAFGKREEDPPPYWGVPAGTYGPPAEGAPAPGLDPATGPAPVDVRPGAEEQGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J8</accession>
    <name>A0A1E7N4J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glutamate synthase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0006760</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551220.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene973"/>
    <dbReference type="EnsemblBacteria" id="ARF80806">
        <property type="protein sequence ID" value="ARF80806"/>
        <property type="gene ID" value="B6264_19530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35610">
        <property type="protein sequence ID" value="OEV35610"/>
        <property type="gene ID" value="HS99_0006760"/>
    </dbReference>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1552" mass="166807" checksum="7F3AC1333855BE5C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4N0</accession>
    <name>A0A1E7N4N0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0032185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1597"/>
    <dbReference type="EnsemblBacteria" id="OEV35423">
        <property type="protein sequence ID" value="OEV35423"/>
        <property type="gene ID" value="HS99_0032185"/>
    </dbReference>
    <dbReference type="OMA" id="LQWKAFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198757" evidence="4">
        <location>
            <begin position="19"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="758"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="910" mass="96323" checksum="E887808A2806364C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y4</accession>
    <name>A0A1E7N4Y4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366868.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene781"/>
    <dbReference type="EnsemblBacteria" id="OEV35761">
        <property type="protein sequence ID" value="OEV35761"/>
        <property type="gene ID" value="HS99_0007735"/>
    </dbReference>
    <dbReference type="OMA" id="WVCRIAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="36009" checksum="CE5D7301D98A8CBB" modified="2017-01-18" version="1">MTGRQHGTPSDGTAEGIGAALERRGFTTRALRARAAVVGVALAVVAAGVGAFLVGNLSNAFGPGSVCEGAVSADALHDALGPGTVGEQKYGDGSLHSGTAFCTATVSYGVFGNERSVTVELRKDTGLSILADNADEAEARMFGASANGGAAGAAFDHRAWALLPEDCGSGLRVAVRSGGSDRPGARKLAGLAVSAANRVAMQRACGKAPMPAPRELSEAGKEHDLDRNAVCGLPGLTLAEAPGSTGLRETVTTATDPLWACRIHSTGDPTSSAAFTIGTEPRLLTVGAPKDEPGLGRARWVEPGEMVTTCHGKPAYFRMSWDGIQKLVPDSDETWKQFLTAGGRAIGCEPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z4</accession>
    <name>A0A1E7N4Z4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281466.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000880.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene768"/>
    <dbReference type="EnsemblBacteria" id="ARF80983">
        <property type="protein sequence ID" value="ARF80983"/>
        <property type="gene ID" value="B6264_20580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35771">
        <property type="protein sequence ID" value="OEV35771"/>
        <property type="gene ID" value="HS99_0007805"/>
    </dbReference>
    <dbReference type="OMA" id="MAIEAKH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="28041" checksum="2B3F8816FDE88C1D" modified="2017-01-18" version="1">MAWPIAEVARMSGVTARTLRHYDEIGLLPPAWIGSNSHRYYEERQLLQLQQILVLRALGVGLAEIARIIGDQVDELESLRSHHRRLVVERDRLDALATTVSRTIADLERSRKDGTPMTSINRPENLFEGIQPADVDASLRDFPEHAEATRRATAAMTPAEIEAGQRERTARMVRLAELMAAGHPADAEPVQHMIDEEYQLLSGLRTVAVADYLAIARSCTDNEQWSAAYEAIAAGLAGYQRAAMEAYAAARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N5</accession>
    <name>A0A1E7N5N5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotran_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7261"/>
    <dbReference type="EnsemblBacteria" id="ARF82978">
        <property type="protein sequence ID" value="ARF82978"/>
        <property type="gene ID" value="B6264_21240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35995">
        <property type="protein sequence ID" value="OEV35995"/>
        <property type="gene ID" value="HS99_0008465"/>
    </dbReference>
    <dbReference type="OMA" id="DDHRANG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="63"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="386" mass="41448" checksum="68DD31062C46FAFC" modified="2017-01-18" version="1">MSSAEPPVPLPAAEGLFSVSPQAAHLNHGSFGAVPLPVQRAQHALRTEHELDPDLFFADLPDRIAAARVRIAAELATDPDRLAMVANVTEAAAIALDSIPFAPGDRILVTDHGYGAVTRAAARRAAETGAELVVAELPVDAPDERAVREAVLAAVDGRTTVAILDRITSPTARTVASPALVAELRERGVTTLVDGAHAPGMLPDPVDPNADFWFGNLHKWAFAPRATGVLSVRPEWTARVRPLALSWEHHRGFPYNVEWRGTCDYTPWLAAPAGFELLRELGTEAVAAHNTGLAAYGQRVLVERAGLRALPAAPGVWMRAVRLPEGRFDTEESARALVTGVWQRLGVRVAVKPWPGGGVLRVSAQLYNRAAEYERLADGLLEVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R0</accession>
    <name>A0A1E7N5R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0008090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367176.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000156_gene6562"/>
    <dbReference type="EnsemblBacteria" id="ARF82969">
        <property type="protein sequence ID" value="ARF82969"/>
        <property type="gene ID" value="B6264_20865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35984">
        <property type="protein sequence ID" value="OEV35984"/>
        <property type="gene ID" value="HS99_0008090"/>
    </dbReference>
    <dbReference type="OMA" id="NMATWML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="41474" checksum="05B3E46A3BABB795" modified="2017-01-18" version="1">MSQDFDLFRISEEHEMLREAVRSLAEAKIAPFAAEVDEQGRFPQEALDALRGNDLHAVHVPEVYGGAGADALATVIVIEEVARVCGSSSLIPAVNKLGSLPVQLSGSEELKAKYLGALARGEGMFSYCLSEPEAGSDAAGMKTRAVRDGDFWVLNGVKRWITNAGVSEFYTVMAVTDPSMRSKGISAFVVEKGDEGVSFGAPEKKLGIKGSPTREVYFDNVRIPADRMIGAEGSGFQTAMRTLDHTRVTIAAQAVGIAQGALDYAKGYVRERKQFGKAIAEFQGIQFMLADMAMKLEAARQMTYVAAAKSQRGDADLTFFGAAAKCFASDVAMEVTTDAVQLLGGYGYTRDYPVERMMRDAKITQIYEGTNQVQRIVMARNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N605</accession>
    <name>A0A1E7N605_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0031055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553167.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4987"/>
    <dbReference type="EnsemblBacteria" id="ARF80054">
        <property type="protein sequence ID" value="ARF80054"/>
        <property type="gene ID" value="B6264_15035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36109">
        <property type="protein sequence ID" value="OEV36109"/>
        <property type="gene ID" value="HS99_0031055"/>
    </dbReference>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="572" mass="60101" checksum="2CAD6B19A94F01CB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N677</accession>
    <name>A0A1E7N677_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene827"/>
    <dbReference type="EnsemblBacteria" id="ARF82953">
        <property type="protein sequence ID" value="ARF82953"/>
        <property type="gene ID" value="B6264_20275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35963">
        <property type="protein sequence ID" value="OEV35963"/>
        <property type="gene ID" value="HS99_0007505"/>
    </dbReference>
    <dbReference type="OMA" id="CLDACEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="12400" checksum="65E71674AF60332A" modified="2017-01-18" version="1">MTVTVCRGCCCGTEAKHPGVDHAGQYERLRTAVGSAGRVRAVTCLDVCTQSNVVVVGPSSEGRAAGGRPVWLGFVLMDEMIDDIAAWAHAGGPGLADPPGLLDLQLISVSRRVREGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6D8</accession>
    <name>A0A1E7N6D8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0030835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284203.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8033"/>
    <dbReference type="EnsemblBacteria" id="ARF79850">
        <property type="protein sequence ID" value="ARF79850"/>
        <property type="gene ID" value="B6264_13890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36238">
        <property type="protein sequence ID" value="OEV36238"/>
        <property type="gene ID" value="HS99_0030835"/>
    </dbReference>
    <dbReference type="OMA" id="KVMTGQY"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34582" checksum="C0F20FB5CD796FBB" modified="2017-01-18" version="1">MTWLITGGAGYIGGHVVRQLLDAGERVAVLDDLSTGDASRVPDGVPLIEGSTLDRAVLDTAIREHGIEGVLHFAAKKQVGESVEQPFLYYRENMIGLQTVLEAAAGGGVKRFLFSSSAAVYGMPDVDLVTESTPCAPMSPYGETKLAGEWLVAAAGKAYGMSTVALRYFNVAGAASPELSDAGVFNLIPMVFERLTAGEAPRVFGDDYATPDGSCVRDFIHVSDIASAHVAAAKRLAADPAGETALVLNIGRGEGVSVKEMIEVIGKVTGYDVTAEVTPRRPGDPARVVAAADLIHRELGWSASHDVADMVSSAWEGWCSRHPEARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F5</accession>
    <name>A0A1E7N6F5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550887.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2649"/>
    <dbReference type="EnsemblBacteria" id="OEV36272">
        <property type="protein sequence ID" value="OEV36272"/>
        <property type="gene ID" value="HS99_0030145"/>
    </dbReference>
    <dbReference type="OMA" id="KHDARMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="192"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="689" mass="74000" checksum="261A3D659424A8CC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I2</accession>
    <name>A0A1E7N6I2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0030305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2616"/>
    <dbReference type="EnsemblBacteria" id="OEV36301">
        <property type="protein sequence ID" value="OEV36301"/>
        <property type="gene ID" value="HS99_0030305"/>
    </dbReference>
    <dbReference type="OMA" id="FWHELVL"/>
    <dbReference type="UniPathway" id="UPA00582">
        <property type="reaction ID" value="UER00644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="499"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="605" mass="64130" checksum="6FCA092EA72D2EAF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M8</accession>
    <name>A0A1E7N6M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0031075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4991"/>
    <dbReference type="EnsemblBacteria" id="OEV36113">
        <property type="protein sequence ID" value="OEV36113"/>
        <property type="gene ID" value="HS99_0031075"/>
    </dbReference>
    <dbReference type="OMA" id="MFQTVPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="32324" checksum="56389A3DD6FD90CF" modified="2017-01-18" version="1">MVRANGAVSLRELARVVQTSEVTVRRDVRALEAEGLLDRRHGGAVLPGGFSREPGYPQKTHLSAAEKSAIADLAAGLVEEGDAVVVGAGTTTQELARRLARVPGLTVVTNSLLVAQALAHANRVEVVMTGGTLRGSNYALVGSGAEQSLQGLRVTKAFISGSGLTAERGLSTANMLSASVDRAMVLAAAEVIVLADHTKLGAAGMFQTVATETITRLVTDEQATADDATARELDALADCGVQIDLAPLGVASGGDAPVHGTGSGPVHQTQPGPVGRRPVPPPGGAPLPGQRRPGTHGGPVGPGGMPVRLAEMGLPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q4</accession>
    <name>A0A1E7N6Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7740"/>
    <dbReference type="EnsemblBacteria" id="ARF82322">
        <property type="protein sequence ID" value="ARF82322"/>
        <property type="gene ID" value="B6264_28690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36387">
        <property type="protein sequence ID" value="OEV36387"/>
        <property type="gene ID" value="HS99_0029975"/>
    </dbReference>
    <dbReference type="OMA" id="NAPDLFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021257">
        <property type="entry name" value="DUF2809"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10990">
        <property type="entry name" value="DUF2809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="14861" checksum="1D79A1078B698892" modified="2017-01-18" version="1">MGPARSLGRVNDLRKALTARLPAAVAVLLTVAAGLGVRAATDGDPAKCAGDALYTVLVYALVVLVAPRVRPVRAALVAAGVSWAVELFQATGLPDAWGRRSGLVHLVLGSTFNPPDLFWYLVGGAGAALLHRVLRSGGTAAPGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N713</accession>
    <name>A0A1E7N713_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-hydroxy-acid oxidizing enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0029275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene233"/>
    <dbReference type="EnsemblBacteria" id="ARF82260">
        <property type="protein sequence ID" value="ARF82260"/>
        <property type="gene ID" value="B6264_28340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36434">
        <property type="protein sequence ID" value="OEV36434"/>
        <property type="gene ID" value="HS99_0029275"/>
    </dbReference>
    <dbReference type="OMA" id="DPSLDWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="38560" checksum="8F1C09F4385C5CDA" modified="2017-01-18" version="1">MSAPTATDRRPPLSVAEFAGPARSALSPEVWDWLAGGAEQEHTLAANRAAFDRLAVVPRVLADVSACDTTATLVRSRSALPVAVAPVAYHRLFHPEGELASARAAAAAGVPFTVGTLSSVGFEELAATGATLWFQLYWLRDRGRLLDLVAAAAAAGSECLVVTADVPYMGRRLRDARNAFALPGDVRAALLEGGAAGRAHRAGAEVSAVAAHTAELLSPAVTWADLAWLHERTELPLVVKGLLDPADALRAAELGAEAVVVSNHGGRQLDRAVPSLTALPAVAEALAGRDCQVLLDSGVRGGSDVLTALALGASGVLLGRPLIWGLAAGGEPGCARVLELLAAELRHALGLAGCADLGAAAELRTTPMPCPAWSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N767</accession>
    <name>A0A1E7N767_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2662"/>
    <dbReference type="EnsemblBacteria" id="OEV36313">
        <property type="protein sequence ID" value="OEV36313"/>
        <property type="gene ID" value="HS99_0030080"/>
    </dbReference>
    <dbReference type="OMA" id="KWVVREH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="4"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="36088" checksum="8E951F113ABB1E2F" modified="2017-01-18" version="1">MYRKVVEQVPVRLAEDEMLLRTRWVSVDPYLQGIALDTPVGDHMGADSIMEVVQAGPAARFAVGDLVQGFGGWRSHVIGNGGSRLWQTGTFPMVFPAYRRLDRADYDEAMPVTTALGLLGGPGMTAWGTVEKFLDVRPGQTVLVSGASGAVGSVVGQLAKHRGARVIGTTATPAKAGWLEELGFDAVLNYRDGDDPERLAKELADLAPDGVDRYFDSLGGTLTDAVFGMLAVDSRVAVCWQWGSQVGGEWAGPRLLPMIMFPRTLIRGIFALEWFTEENWSALRRDLGALVRSGDLRYRQTVHRGFDSIPAAYRSLYADRSASRGKVLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H7</accession>
    <name>A0A1E7N7H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278905.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2521"/>
    <dbReference type="EnsemblBacteria" id="OEV36657">
        <property type="protein sequence ID" value="OEV36657"/>
        <property type="gene ID" value="HS99_0028230"/>
    </dbReference>
    <dbReference type="OMA" id="DNVWGYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24745" checksum="4672ED946B5464CE" modified="2017-01-18" version="1">MHILVVEDEHRMATALRRGLEADGHTVDTAHNGPEGLALAERHPYDVIVLDIMLPGLNGYRVCARLRAGGCRAGILMLTAKDGEWDEAEALDTGADDYLSKPFSFVVLLARLRALHRRIDRQRPRLHTLGDLVLDANARTCTRAGTPTHLTAREFAILEHLAARAGTVVSKREILDHVWDADHDADPSIVEVHVHALRRKIDAPFGRAALQTMRGAGYRLDPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K1</accession>
    <name>A0A1E7N7K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278928.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2533"/>
    <dbReference type="EnsemblBacteria" id="OEV36649">
        <property type="protein sequence ID" value="OEV36649"/>
        <property type="gene ID" value="HS99_0028175"/>
    </dbReference>
    <dbReference type="OMA" id="WVAACPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="246"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="548"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="607" mass="67300" checksum="F6C2404DFC46440E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Q9</accession>
    <name>A0A1E7N7Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550664.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000304.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2460"/>
    <dbReference type="EnsemblBacteria" id="ARF83029">
        <property type="protein sequence ID" value="ARF83029"/>
        <property type="gene ID" value="B6264_23810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36725">
        <property type="protein sequence ID" value="OEV36725"/>
        <property type="gene ID" value="HS99_0028525"/>
    </dbReference>
    <dbReference type="OMA" id="LEHEFAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="567" mass="59791" checksum="2D705F86C1A7C1DB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7W2</accession>
    <name>A0A1E7N7W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386611.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4824"/>
    <dbReference type="EnsemblBacteria" id="ARF82434">
        <property type="protein sequence ID" value="ARF82434"/>
        <property type="gene ID" value="B6264_29345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36786">
        <property type="protein sequence ID" value="OEV36786"/>
        <property type="gene ID" value="HS99_0027665"/>
    </dbReference>
    <dbReference type="OMA" id="AGVDQWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="23229" checksum="A3B7919D052FFA7A" modified="2017-01-18" version="1">MTVRTAPRRTAGLLPLLLDLVLPLGVYYGLRLAGVDQWWSLLWSAAVPAATVVVRLIRTRRVDFLALLILSMIGLGLLLSTLTGDPRTLLVREAWTGMLGGLIGVWLLASVGYGRPALMVLFRSFVQVKAGEDGLRAWEGRWHQDAAFRRGLRVLTTVWGAASLLNALAQLVFAHLLPVDAAPAAMQACWPVIAVPLFLFHLAYTKRQGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Y2</accession>
    <name>A0A1E7N7Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7896"/>
    <dbReference type="EnsemblBacteria" id="ARF79133">
        <property type="protein sequence ID" value="ARF79133"/>
        <property type="gene ID" value="B6264_09570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36563">
        <property type="protein sequence ID" value="OEV36563"/>
        <property type="gene ID" value="HS99_0029015"/>
    </dbReference>
    <dbReference type="OMA" id="GGNALMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30929" checksum="FD8BEA8FE810F6A1" modified="2017-01-18" version="1">MRISEFRNGKAEARFRAAYEHAFTQLWPGRRTPLDVPTRFGTTRVHRTGPAHGQPIVLLPGSGGNALMWHAYVEPLAEHHPVLAVDTLGEPGASVQSAPIEGGHDAADWLEDLLAALDVPAAHVVGCSYGGWIALHHQIRHPGRTAALTLVDPAGLADAGRRFYTWLVLGGLAALAPRPLRPRLAGAVGNSAVLETELMTLMRASMGFRRRLPLADTLGDEQLSRLSAPALFLLGERSALNDPRTVSERLHRLAPAARVEVVPGAGHALPTDDPAAVLAGILSMSATHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F8</accession>
    <name>A0A1E7N8F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557261.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000468.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene163"/>
    <dbReference type="EnsemblBacteria" id="ARF81757">
        <property type="protein sequence ID" value="ARF81757"/>
        <property type="gene ID" value="B6264_25215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36972">
        <property type="protein sequence ID" value="OEV36972"/>
        <property type="gene ID" value="HS99_0003800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11183" checksum="D1F3BB031923675A" modified="2017-01-18" version="1">MPESVPHGDQPRPPRATEGIADDTAEQLSALDEQLIAQLVHRIRLARGHQLSRRAAGLPTTSLAQENAMLLRYAARLGDQGAGIALAILELSRPPASPAPAPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8G3</accession>
    <name>A0A1E7N8G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557235.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene144"/>
    <dbReference type="EnsemblBacteria" id="ARF81740">
        <property type="protein sequence ID" value="ARF81740"/>
        <property type="gene ID" value="B6264_25120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36986">
        <property type="protein sequence ID" value="OEV36986"/>
        <property type="gene ID" value="HS99_0003895"/>
    </dbReference>
    <dbReference type="OMA" id="PMPIAAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="48540" checksum="AE13D6866AA80101" modified="2017-01-18" version="1">MTEPDLFEVVNPATEEVITTVELAGTAETDAAVARARAAFDTWRRVAPADRARLLRAFAAAVDADREHLAALEVANAGHTIGNARWEAGNARDVIEYYAAAPERLFGRQIPVAGGIDVTFQEPIGVVGVIVPWNFPMPIAAWALAPALAAGNTVIVKPAELTPLTALRLAELALEAGIPEGVLQVLPGRGPVVGQRFVTHPDVRKVVFTGSTRVGKEIMAGCAAQVKPVTLELGGKSANIVFADADLAKAAATAPYAVFDNAGQDCCARSRILVEHSAFDDFMALLEPAVRGVRVGDPADEKTEMGPLISAAHRERVSSYVPDASAVAFRGSAPDGPGFWYPPTVLAPVRHEDRAFTEEVFGPVVAVVPFRDEQDALRIANATEYGLSGSIWTRDLGRALRVSRGVEAGNLSVNSHSSVRYTTPFGGFKQSGLGRELGPDALDAFTQTKNVFISTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8J9</accession>
    <name>A0A1E7N8J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386355.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5969"/>
    <dbReference type="EnsemblBacteria" id="ARF81715">
        <property type="protein sequence ID" value="ARF81715"/>
        <property type="gene ID" value="B6264_24960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37011">
        <property type="protein sequence ID" value="OEV37011"/>
        <property type="gene ID" value="HS99_0004050"/>
    </dbReference>
    <dbReference type="OMA" id="TWGEYAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="20852" checksum="E79787650E23FDF0" modified="2017-01-18" version="1">MNVNLTIEATYVLGPALAAFLALAAVRHHRAQPGWTGRHVVLRAAACLYAAAVLSITVFPLEVTWGKYANQMPWWNQINFVPLVTADMTAMPNILMFVPLGVTLPLLTRVSSTVRAVGVSALASLCIESTQLLSYVLFNNGRAVDINDLLANTLGGLFGYLLVRLSLGRPSARELLRRFALPGSAAGRPVVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N949</accession>
    <name>A0A1E7N949_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557216.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81733">
        <property type="protein sequence ID" value="ARF81733"/>
        <property type="gene ID" value="B6264_25070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36993">
        <property type="protein sequence ID" value="OEV36993"/>
        <property type="gene ID" value="HS99_0003945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20497" checksum="2FCC9BCDB9EBA5B5" modified="2017-01-18" version="1">MPSWTVYLTEPGTRHAVLALPRAMAAPDHGVHFIACSFGPVPDPTRMLMVVQHRDLPRVRTVDLRTLPSAGHGALSWLATPGALRGTGPEPAHVWHCGLLRTPSLVFTHLEANPSVPDALAAPGWELSPYRSGGRSGPLAADFTPSRLLHGTSTGGDRFSSYDAIFEAPEAAASFTWTCVPLELSTTQSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA08</accession>
    <name>A0A1E7NA08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552700.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7993"/>
    <dbReference type="EnsemblBacteria" id="OEV37519">
        <property type="protein sequence ID" value="OEV37519"/>
        <property type="gene ID" value="HS99_0026250"/>
    </dbReference>
    <dbReference type="OMA" id="EQAYHPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="24021" checksum="A7A7D6E63425E0F4" modified="2017-01-18" version="1">MLTLHRAALVLPDPADPTAPSIADGAVVVRGELVEAVGPYGELAAAHPSARVRDWGTAAVLTPGLRNPWGQRLLERDYHPDPREEIGVEPVVDGLVGCTDETRYGASARRGLQRMLGFGVTAVAGPFERAAVRTAVARSGLAALPGASDAGAGAGAGAAAGAGSLDPLAVLPLPLAVHGRVAAGGRADFAVFPGLPVLSGLSGLSGVSGLSGLAVGGGDGVLPAAGGCLATVLGGRLVYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAA3</accession>
    <name>A0A1E7NAA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290453.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000592.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6257"/>
    <dbReference type="EnsemblBacteria" id="ARF79874">
        <property type="protein sequence ID" value="ARF79874"/>
        <property type="gene ID" value="B6264_14035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37619">
        <property type="protein sequence ID" value="OEV37619"/>
        <property type="gene ID" value="HS99_0025250"/>
    </dbReference>
    <dbReference type="OMA" id="VIMEHIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24283" checksum="C89A5440FB8DCC9A" modified="2017-01-18" version="1">MSEILIVDDEPAILRTLRINLSARQYAVRTAATGGEALDRAAHSAPDAVLLDLGLPDLDGMDVLCGLRTRSTMPVIVLSGRSDAADRIGALDAGADDYLTKPFLMDELLARLRAVLRRPLGAVPPERAVIGDHTVDLAATTVLGPGGPVRLTPTEWRILGLLLATPGRLVPGRQILREVWGPAQETRGNYLRVYLAGLRRKLEPDPARPRHLITEPGIGYRYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC5</accession>
    <name>A0A1E7NAC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555225.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1328"/>
    <dbReference type="EnsemblBacteria" id="OEV37443">
        <property type="protein sequence ID" value="OEV37443"/>
        <property type="gene ID" value="HS99_0005425"/>
    </dbReference>
    <dbReference type="OMA" id="DAYWVKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="3">
        <location>
            <begin position="259"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="54854" checksum="6E403A2F6108998C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG3</accession>
    <name>A0A1E7NAG3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">HS99_0025595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030232478.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1675"/>
    <dbReference type="EnsemblBacteria" id="ARF79936">
        <property type="protein sequence ID" value="ARF79936"/>
        <property type="gene ID" value="B6264_14385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37679">
        <property type="protein sequence ID" value="OEV37679"/>
        <property type="gene ID" value="HS99_0025595"/>
    </dbReference>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8385" checksum="9EB432C222E9FA48" modified="2017-01-18" version="1">MSAATKAAELRSLDNEGLVAKLREAKEELFNLRFQAATGQLDNHGRLKLVRKDIARIYTLMRERELGIETVENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN5</accession>
    <name>A0A1E7NAN5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290150.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000820.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3442"/>
    <dbReference type="EnsemblBacteria" id="ARF78110">
        <property type="protein sequence ID" value="ARF78110"/>
        <property type="gene ID" value="B6264_03530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37757">
        <property type="protein sequence ID" value="OEV37757"/>
        <property type="gene ID" value="HS99_0024480"/>
    </dbReference>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="37135" checksum="A74E002A291057CC" modified="2017-01-18" version="1">MRTAVVVGTGLIGTSAALALAARGLTVHLEDADPDAARTAESLGAGTTEPAEGPVDLAIIAVPPALVGKVLADCQRRNLAHWYTDVASVKSGPGSEIAALGLDTVHYIGSHPMAGRERSGPLAARADLFEGRPWVLTPTADTDTDTLNAALELVALCGAMPIVMDADAHDRAVALVSHAPQLVSSLVAARLENADETAIRLSGQGVRDVTRIAASNPALWVDILSANAGAVADVLEEVAGDLGETVVALRALAAEEEGERRAGALGIEAVMRRGNTGQARIPGKHGAPPTRYETVAVVLGDQPGELGRLFGEVGEAGVNIEDVLIEHSDGQQVGFVQLSVAPTSVKRLTAALRAGGWSVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB16</accession>
    <name>A0A1E7NB16_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0232 protein HS99_0023770</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0232 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278245.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2125"/>
    <dbReference type="EnsemblBacteria" id="ARF79446">
        <property type="protein sequence ID" value="ARF79446"/>
        <property type="gene ID" value="B6264_11440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37896">
        <property type="protein sequence ID" value="OEV37896"/>
        <property type="gene ID" value="HS99_0023770"/>
    </dbReference>
    <dbReference type="OMA" id="RWPQIVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00630">
        <property type="entry name" value="UPF0232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023007">
        <property type="entry name" value="UPF0232_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="18910" checksum="A1DA784CA4427FED" modified="2017-01-18" version="1">MSESAETSPGPGAEGPTGADLARSALRAARAQARQRGEQVQQKREAKRHGLRSGARSDGRDPVPLGAALNRLLTERGWESSAAVGGVMGRWPQIVGPDISAHCHPSSYDEAAAVLTVQCDSTAWATQLRWLARQLVARLNHELGHGTVRTIKVLGPAAPVRGYGRLRAPGSKGPGDTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB99</accession>
    <name>A0A1E7NB99_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2035"/>
    <dbReference type="EnsemblBacteria" id="OEV37970">
        <property type="protein sequence ID" value="OEV37970"/>
        <property type="gene ID" value="HS99_0024225"/>
    </dbReference>
    <dbReference type="OMA" id="SVAMTGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="397" mass="43153" checksum="391F056E849D808E" modified="2017-01-18" version="1">MALTTSREEPPMGTRPLLNRRLAGMGTTIFAEMSALATATGSINLGQGFPDTDGPEEVREAAVRALREGRGNQYPPGPGIPELRHAIAEHQQRFHGLTYDPDTEVLVTAGATEAIAAALLALLEPGDEVIALEPFYDSYAACIAMAGATRRPLTLRAPHFRPDLDELRALITPRTRLLLINTPHNPTGTVLAPGELAAIAALAVEHDLLVITDEVYEHLVFGATHHPLAALPGMRERTVTISSAGKTFSFTGWKVGWVTASPALVSAVRTAKQYLTYVSAGPFQYAVAEALRLPDDYFRTLRTDLLRKRDLLLDGLTAAGFRAFTPEGTYFITTDITPLGEKDGIDFCRSLPERCGVVAIPNAVFYDNTDAGRSLVRFTFCKKDEVLTEAVTRLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC6</accession>
    <name>A0A1E7NBC6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="9" type="ORF">HS99_0024125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278326.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2054"/>
    <dbReference type="EnsemblBacteria" id="ARF79508">
        <property type="protein sequence ID" value="ARF79508"/>
        <property type="gene ID" value="B6264_11800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37954">
        <property type="protein sequence ID" value="OEV37954"/>
        <property type="gene ID" value="HS99_0024125"/>
    </dbReference>
    <dbReference type="OMA" id="TKFEFGF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="33322" checksum="AF0CD20B08263CE0" modified="2017-01-18" version="1">MSGFVTKPEPVQVPGLVHLHTGKVRDLYRTGTGELVMVASDRMSAHDWVLPNEIPDKGRVLTQLSLWWFERIADIVPNHVISTEVPAGAPADWKGRTLICKSLDMIPVEAVARGYLAGSGLTEYRESRTVCGIALPEGLENSSELPAPIYTPALKAEVGEHDENVPYEETARRIGAELAAQVRRTTLDVYARARDIARDRGIILADTKFEFGLLDGELVIGDEVLTPDSSRYWPADEYHPGRSQASFDKQLIRDWLVSPASGWDRYSEQPPPELPAEVVEQTRAKYIEVYERLTGTSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD8</accession>
    <name>A0A1E7NBD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2115"/>
    <dbReference type="EnsemblBacteria" id="ARF82771">
        <property type="protein sequence ID" value="ARF82771"/>
        <property type="gene ID" value="B6264_11495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38010">
        <property type="protein sequence ID" value="OEV38010"/>
        <property type="gene ID" value="HS99_0023825"/>
    </dbReference>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="31"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="33176" checksum="F6F620E01A6DAA9C" modified="2017-01-18" version="1">MDDTPIARAAQAAVQAIGRAGEGLPRPAATRVIVVANQKGGVGKTTTTVNMAASLAMHGLRVLVVDLDPQGNASTALGIDHHAEVPSIYDVLVEGKPMADVVQPVVDVEGLFCVPATIDLAGAEIELVSLVARESRLQRAIAAYEQPLDYILIDCPPSLGLLTVNALVAGREVLIPIQCEYYALEGLGQLLRNVELVRAHLNPALHVSTILLTMYDARTRLAAQVAEEVRTHFRNEVLSTAIPRSVRISEAPSYGQTVLTYDPGSTGALSYLEAARELAQRAVGPGGGSLVGQQRGGSSTGHGAPVAQHGTTEGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP7</accession>
    <name>A0A1E7NBP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835591.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3022"/>
    <dbReference type="EnsemblBacteria" id="ARF79715">
        <property type="protein sequence ID" value="ARF79715"/>
        <property type="gene ID" value="B6264_13090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38074">
        <property type="protein sequence ID" value="OEV38074"/>
        <property type="gene ID" value="HS99_0023010"/>
    </dbReference>
    <dbReference type="OMA" id="RTSRDQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015064147" evidence="4">
        <location>
            <begin position="26"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="46586" checksum="AF9D6A2E8F0E24A0" modified="2017-01-18" version="1">MARRILPTLLLSLTALLGLLPAAQADPADPDPATGRPPGGQPSEVRSPSVRSPAGQAPAGQPPVGQDPYPSTEEIDRSRTEADGNAVSAAALEAALTAARAELDRAGRSAEQAVEAYNGARLALTRARTEETAANRRAAAAETERSEAAEDAARLAAETYRQGAGAELSALNALLGAHGPREAGDRAAAVGVVSERTRQILDAATSTAAAARSASAAARTATEAAEKAAAEVGAARTRAQQRLAAQQGEVAAADRRRERLLAELAAARNTTVELERERREALEAIAAREAEAGAAARASAEQAARDAETAAAAARAQAVLPEPRPWSAEGAAAAVAFAKSKIGLPYVWGGEGQEGYDCSGLTMMAWREGGKQLNHFAADQYAQSTPIGYGQLRPGDLVFWTDTGRAADIHHVGLYIGDDQMIEAPRVGMPVKQASLWIMGIPDYYARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY7</accession>
    <name>A0A1E7NBY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552044.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2020"/>
    <dbReference type="EnsemblBacteria" id="ARF79538">
        <property type="protein sequence ID" value="ARF79538"/>
        <property type="gene ID" value="B6264_11975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37983">
        <property type="protein sequence ID" value="OEV37983"/>
        <property type="gene ID" value="HS99_0024295"/>
    </dbReference>
    <dbReference type="OMA" id="EMHRHKE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="740" mass="81350" checksum="9C96302CD391AD21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC58</accession>
    <name>A0A1E7NC58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284078.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000103.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4194"/>
    <dbReference type="EnsemblBacteria" id="ARF80197">
        <property type="protein sequence ID" value="ARF80197"/>
        <property type="gene ID" value="B6264_15890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38286">
        <property type="protein sequence ID" value="OEV38286"/>
        <property type="gene ID" value="HS99_0022380"/>
    </dbReference>
    <dbReference type="OMA" id="DPVLWDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16296" checksum="213D0FFD554E87F9" modified="2017-01-18" version="1">MTGIWVVLAVAGVAVLAAVAAALARRTRPAARPTGPTGPRPRPGTKAGPEPQEIWWAEVPFEDGPGSKDRPCLVLRVHGRAATVAKITSKHHAERPGVLPLPPGSVGDRQGRTSWLETDELREVPLSAFRRRAGTVDRQVWARAQRALQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC78</accession>
    <name>A0A1E7NC78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284079.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000103.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4195"/>
    <dbReference type="EnsemblBacteria" id="ARF80198">
        <property type="protein sequence ID" value="ARF80198"/>
        <property type="gene ID" value="B6264_15895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38285">
        <property type="protein sequence ID" value="OEV38285"/>
        <property type="gene ID" value="HS99_0022375"/>
    </dbReference>
    <dbReference type="OMA" id="AHIRVQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="62" mass="7445" checksum="F95E2ED32FE3A6ED" modified="2017-01-18" version="1">MEDPELWSYAEIARHINVRPETVRNYRRHGLLPDPDVTDGSGHPRWYPGTIRSWARNRPRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCK9</accession>
    <name>A0A1E7NCK9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000276.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene287"/>
    <dbReference type="EnsemblBacteria" id="ARF82188">
        <property type="protein sequence ID" value="ARF82188"/>
        <property type="gene ID" value="B6264_27895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38421">
        <property type="protein sequence ID" value="OEV38421"/>
        <property type="gene ID" value="HS99_0021160"/>
    </dbReference>
    <dbReference type="OMA" id="LGNVQYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="552" mass="58398" checksum="A60F0E73F573138F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ3</accession>
    <name>A0A1E7NCZ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281317.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene685"/>
    <dbReference type="EnsemblBacteria" id="ARF77582">
        <property type="protein sequence ID" value="ARF77582"/>
        <property type="gene ID" value="B6264_00375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38559">
        <property type="protein sequence ID" value="OEV38559"/>
        <property type="gene ID" value="HS99_0019960"/>
    </dbReference>
    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="37292" checksum="EAA5555115EDD091" modified="2017-01-18" version="1">MSVAVQGATGKGSRERDQRPGLLERLKRSYARHWYAYAMIAPVVLVLGVLVFYPLVQGIWLTLTDANSLNVARHIGVNEIPASYQYIGFHNYADILWGPGSYDRFWSHFVWTIAWTVICVCLHYTLGLGLAVLLNKKLRGRAAYRMLLILPWAVPTFVTVFSWRLMLSDGGVVNTVLSGLHLPEPGWLTDPWAQKAAAILVNTWAGVPFMMISLLGGLQSIPAELYEAAEMDGATRWQQFRHITLPGLRSVSSTVVLLGVIWTFNQFNVIFLLFGKGAPDAQLLVTWAYRLAFGQIPQDFAQSASYGVILLSILIVFTAFYRRWLARNEQANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND02</accession>
    <name>A0A1E7ND02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551505.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000379.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene670"/>
    <dbReference type="EnsemblBacteria" id="ARF77595">
        <property type="protein sequence ID" value="ARF77595"/>
        <property type="gene ID" value="B6264_00450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38570">
        <property type="protein sequence ID" value="OEV38570"/>
        <property type="gene ID" value="HS99_0020035"/>
    </dbReference>
    <dbReference type="OMA" id="DHRVWGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="2">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20876" checksum="F9E6BF46D1429CEC" modified="2017-01-18" version="1">MTPPATVGSDRLTERMAALVSEIRAVVDRGLPPELTAYLVGERLAPHLLTAPDGSDALLTPAQREGDPQRYRQHVLHAEADGSFSVVALVWLPGQHTPIHDHVSWCVAGVHQGQESETRYRLVSDGRSSRLVETEHVAGPAGTVAAFAPPGDIHLVRNSCSTTAISIHVYGADVSRLGTSIRRVYRLPADQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND93</accession>
    <name>A0A1E7ND93_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="2" type="ORF">HS99_0020370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551442.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000383.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene604"/>
    <dbReference type="EnsemblBacteria" id="ARF77648">
        <property type="protein sequence ID" value="ARF77648"/>
        <property type="gene ID" value="B6264_00785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38618">
        <property type="protein sequence ID" value="OEV38618"/>
        <property type="gene ID" value="HS99_0020370"/>
    </dbReference>
    <dbReference type="OMA" id="FSHNGAV"/>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26346" checksum="40981EE2598CE703" modified="2017-01-18" version="1">MCRHIAYLGEPLAPQELLVHPPYALYRQSWAPRTQQYGTVNVDGFGLGWYADGDELPARYRRAGPIWADATFADLARVIRTGALLAAVRSATEGCAAGEGAAAPFAAGRWLFSHNGAVAGWPGKLDALAALLPPAELLELEARSDSALLWALTLHRLRRGADLGEALAGTVADVAAHTTGRLNLLLTDGTSLAATTWGDDLHHRGLPGLGTVVASEPYDDDPGWTSVPDGSLLLADAGGVRVRQLPSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE5</accession>
    <name>A0A1E7NDE5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Squalene--hopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385648.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene651"/>
    <dbReference type="EnsemblBacteria" id="ARF82532">
        <property type="protein sequence ID" value="ARF82532"/>
        <property type="gene ID" value="B6264_00545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38705">
        <property type="protein sequence ID" value="OEV38705"/>
        <property type="gene ID" value="HS99_0020130"/>
    </dbReference>
    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="674" mass="74943" checksum="1D1BC0DF57DBEBCA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDK6</accession>
    <name>A0A1E7NDK6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TesB-like acyl-CoA thioesterase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7379"/>
    <dbReference type="EnsemblBacteria" id="ARF81194">
        <property type="protein sequence ID" value="ARF81194"/>
        <property type="gene ID" value="B6264_21870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38787">
        <property type="protein sequence ID" value="OEV38787"/>
        <property type="gene ID" value="HS99_0019135"/>
    </dbReference>
    <dbReference type="OMA" id="GWFGLAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="29059" checksum="51C01581E9232D9D" modified="2017-01-18" version="1">MTTAIRSEFDLGIALTGHPEEAGRYEAELGAGWQIGGGVNGGLLLAVAGHALSLEHGQHPDPVSISGYYLSASTPGPATVRTEVLRTGRGLSTGTASLSQDGVERLRVVASHGDLGTVDGEVRTSATPPQLPPPDQCIGVEHAPKELIEQAALLERFDLRLDPATVGWALGQPSGQGRIQGWFRLADGREPDPLLLLLVADALPPVTFDLGLPGWAPTVELTVHLRAKPAPGWLRVVHSTRNLAGGYFEEDAEVWDSAGRLVAQSRQLARAPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT2</accession>
    <name>A0A1E7NDT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6267"/>
    <dbReference type="EnsemblBacteria" id="ARF81220">
        <property type="protein sequence ID" value="ARF81220"/>
        <property type="gene ID" value="B6264_22035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38815">
        <property type="protein sequence ID" value="OEV38815"/>
        <property type="gene ID" value="HS99_0019300"/>
    </dbReference>
    <dbReference type="OMA" id="VRIMYLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046187">
        <property type="entry name" value="DUF6215"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19721">
        <property type="entry name" value="DUF6215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="26436" checksum="B99ADCC50BE8604A" modified="2017-01-18" version="1">METGAEGAGTAAGTETAAEPDGGGATPRVGLQVGAAVVPVGVLFAGLWVLAGRERDGVAPAKCTAATEKDSPKYPALCAALNRPDQPVLVGVPEERVLVAQPGLSAALGPGLTKEDYGSAEVQFRELYVELADHGDVDVADFPSPGDPTIARTPVLGHQALVYRSPTISFSIPLGGGKSTTGTGSAAHSLAVAKNQDGTGGTFEVSIWRKDSGPIDDATLYRVAEAVLPGLQGWAGETVGGTPTGGSPTAGSPTAGSPTGRPTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV8</accession>
    <name>A0A1E7NDV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556343.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5135"/>
    <dbReference type="EnsemblBacteria" id="ARF81256">
        <property type="protein sequence ID" value="ARF81256"/>
        <property type="gene ID" value="B6264_22240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38852">
        <property type="protein sequence ID" value="OEV38852"/>
        <property type="gene ID" value="HS99_0019505"/>
    </dbReference>
    <dbReference type="OMA" id="MNDIHIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="11320" checksum="5B8DEEC671C0A284" modified="2017-01-18" version="1">MNDIHIRTDVLRQSAAGLQAAAAAVGPAGHWLDTSFTAAATMTAWESGPALKDCATAWQTHMKSALDQLHVYAEQLRNSAHSYDKAEQEAARRLTAAVTDLQGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE84</accession>
    <name>A0A1E7NE84_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="9" type="ORF">HS99_0019230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290285.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000241.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7398"/>
    <dbReference type="EnsemblBacteria" id="ARF81211">
        <property type="protein sequence ID" value="ARF81211"/>
        <property type="gene ID" value="B6264_21965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38803">
        <property type="protein sequence ID" value="OEV38803"/>
        <property type="gene ID" value="HS99_0019230"/>
    </dbReference>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32968" checksum="D98CAF1336B99C65" modified="2017-01-18" version="1">MRLVFAGTPEVAVPALDALLASDRHEVVAVVTRPDAPAGRGRKLVASPVAQRAEEAGIEVLKPAKPSDPDFVARLTELAPDCCPVVAYGALLRPGTLEIPVHGWVNLHFSLLPAWRGAAPVQHAVLAGDEVTGASTFLIEQGLDSGPVYGVITEEIRPSDTSGELLTRLSHSGARLLAATMDGIEDGSLYAVPQPAEGVTLAPKISVEDARIEWNHPALRIDRVVRGCAPAPGAWTEFRGERLKVTGPVKLLPDTAELAPGEVAMVGKNSVRVGTGSHDIELGEVRPQGKKEMRAADWARGARLEAGERFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC7</accession>
    <name>A0A1E7NEC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557501.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1011"/>
    <dbReference type="EnsemblBacteria" id="ARF83284">
        <property type="protein sequence ID" value="ARF83284"/>
        <property type="gene ID" value="B6264_30585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39050">
        <property type="protein sequence ID" value="OEV39050"/>
        <property type="gene ID" value="HS99_0018305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13926" checksum="568C7F2C29629409" modified="2017-01-18" version="1">MDTIHLGAAPGTTWALSPLEAEDHLRARFPDLQAGQEHSPTTGKNYVSFYVELAGESRHGAYFERGHLVLDDGDADLWADTAAWFLGLLPADARAVAMVESSPDSVRTIPPGADTAQVREILQSLLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NET9</accession>
    <name>A0A1E7NET9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3538"/>
    <dbReference type="EnsemblBacteria" id="OEV39221">
        <property type="protein sequence ID" value="OEV39221"/>
        <property type="gene ID" value="HS99_0000375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7340" checksum="81E7C92CA70CEFBD" modified="2017-01-18" version="1">MTAIPLQIADLTGSPPAAGAVGAVELVPTVLFGLYGGVLADRADRRTVALATEVALTVLSTLLLANALIGTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ4</accession>
    <name>A0A1E7NEZ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285270.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3568"/>
    <dbReference type="EnsemblBacteria" id="ARF82442">
        <property type="protein sequence ID" value="ARF82442"/>
        <property type="gene ID" value="B6264_29390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39244">
        <property type="protein sequence ID" value="OEV39244"/>
        <property type="gene ID" value="HS99_0000525"/>
    </dbReference>
    <dbReference type="OMA" id="WHAEVER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7728" checksum="0360A981F12D4370" modified="2017-01-18" version="1">MPFPSEAVRFDAPCGIGPDGHWQCWFALRVDAEVLRPLGLHPDQPTSAANPTGPPGWWHAEVERLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF87</accession>
    <name>A0A1E7NF87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556016.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39369">
        <property type="protein sequence ID" value="OEV39369"/>
        <property type="gene ID" value="HS99_0001280"/>
    </dbReference>
    <dbReference type="OMA" id="QREICAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199169" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8041" checksum="22632455E1AEB4F8" modified="2017-01-18" version="1">MTVTQRLTTVAVLAAAAFALGGVPAFAIEHVRHLDPPVTALQCEEGRGFVAADIRTRREFCVGGEFNDHFVAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI8</accession>
    <name>A0A1E7NFI8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285938.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3129"/>
    <dbReference type="EnsemblBacteria" id="OEV39447">
        <property type="protein sequence ID" value="OEV39447"/>
        <property type="gene ID" value="HS99_0001740"/>
    </dbReference>
    <dbReference type="OMA" id="HLVHGYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="144"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="29949" checksum="AEDE437EBFD97354" modified="2017-01-18" version="1">MTEPVIVGVDGSGRSLRALMWATHEAALHNAALRVVHVLPTWEHDIPFHPPGMWLSVRDHGVDILTEAATIAKESRPGLDVSAELMVGHPAAVFVDLSKQASAVVLGARGEGGLSNVLLGSVSLQVSGHAEAPVVVVGYVSGGNDRILVGTDGSESSSAALAYAFEEASLRRAALHVLRAWGLPTPPDDSTVPDPEQIAEDYRQECERGLAVLRARYPDINVQVELVRSRPSDALIRASGRADLAVVGSRGKGGFHGLAVGSVSHALLQDASCPVAVIRSKSPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK7</accession>
    <name>A0A1E7NFK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0002000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367038.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5075"/>
    <dbReference type="EnsemblBacteria" id="OEV39489">
        <property type="protein sequence ID" value="OEV39489"/>
        <property type="gene ID" value="HS99_0002000"/>
    </dbReference>
    <dbReference type="OMA" id="QYIEWLE"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2040"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3102"/>
            <end position="3177"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4144"/>
            <end position="4219"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5165"/>
            <end position="5240"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6599"/>
            <end position="6674"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="7640"/>
            <end position="7715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3083"/>
            <end position="3105"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2075"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3137"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4179"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="5200"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="6634"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="7675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="7992" mass="857104" checksum="802F548B17464402" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM7</accession>
    <name>A0A1E7NFM7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Gas vesicle structural protein</fullName>
            <shortName evidence="4">GVP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gvpA</name>
        <name evidence="7" type="ORF">HS99_0001895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
            <location evidence="4">Gas vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the gas vesicle protein type A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5097"/>
    <dbReference type="EnsemblBacteria" id="OEV39472">
        <property type="protein sequence ID" value="OEV39472"/>
        <property type="gene ID" value="HS99_0001895"/>
    </dbReference>
    <dbReference type="OMA" id="ITIDARI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033172">
        <property type="term" value="C:gas vesicle shell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00576">
        <property type="entry name" value="Gas_vesicle_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018493">
        <property type="entry name" value="Gas-vesicle_GvpA_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00234">
        <property type="entry name" value="GAS_VESICLE_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00669">
        <property type="entry name" value="GAS_VESICLE_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15896" checksum="C800D8ADC3FBCF99" modified="2017-01-18" version="1">MTVVPQSAAGVSRSGNTGSLYDVLELILDRGLVIDVFVRVSLVGIEILKIDIRIVVASVDTYLRFAEACNRLDLESGRKAPAQLTDIVGEVTEGGARGKSKGALSGAVDAVTDALHLGDANEEEEEEEEPAPRRTRPARRPTRRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN1</accession>
    <name>A0A1E7NFN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5115"/>
    <dbReference type="EnsemblBacteria" id="OEV39458">
        <property type="protein sequence ID" value="OEV39458"/>
        <property type="gene ID" value="HS99_0001800"/>
    </dbReference>
    <dbReference type="OMA" id="DADRRCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17234" checksum="E16AC753B49959C6" modified="2017-01-18" version="1">MDGAGPDADRRCLFLLWFMGAVRDYVGHRADRLFATLFLGGGLLSAAMPFVLAAMAERLVGAPGGTQPQLWGFDRHLALTVLVVSQAMRMALVFTRSATTVRCGLALFPRSLGRLGCLVALVPLFVVTSLPWSEPAFPAWVLAVSGQILRSSFGAPQAMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG00</accession>
    <name>A0A1E7NG00_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0002840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550332.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2762"/>
    <dbReference type="EnsemblBacteria" id="OEV39626">
        <property type="protein sequence ID" value="OEV39626"/>
        <property type="gene ID" value="HS99_0002840"/>
    </dbReference>
    <dbReference type="OMA" id="DIWIMLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="8">
        <location>
            <begin position="151"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="9">
        <location>
            <begin position="252"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="6">
        <location>
            <begin position="434"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV39626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="552" mass="56222" checksum="983A6F10A78CD3EB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG17</accession>
    <name>A0A1E7NG17_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HPr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279216.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2763"/>
    <dbReference type="EnsemblBacteria" id="OEV39627">
        <property type="protein sequence ID" value="OEV39627"/>
        <property type="gene ID" value="HS99_0002845"/>
    </dbReference>
    <dbReference type="OMA" id="APHGIHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="9043" checksum="D92BF2ADCBB7F086" modified="2017-01-18" version="1">MPSIQITVGSSSGLHARPASLFVQAASRRQAKVTVGRPGQAPVDARSLLSVLALAARCGDTLELTASGDGAEEALEALADLLSSDLDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG39</accession>
    <name>A0A1E7NG39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550395.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2811"/>
    <dbReference type="EnsemblBacteria" id="OEV39666">
        <property type="protein sequence ID" value="OEV39666"/>
        <property type="gene ID" value="HS99_0003085"/>
    </dbReference>
    <dbReference type="OMA" id="RFFAEPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="36753" checksum="6DE78670CDA45517" modified="2017-01-18" version="1">MSRAAQQPPAARPTLEAVAARAGVGRGTVSRVVNGSSKVSAKARAAVEQAIAELGYVPNQAARSLVTSRTDAVALVIPESVAKLSSEPYFSDIITGVSAELADSDLQLLLVLVRDEHERERLSRYLTARRVDGVLLVSVHQDDPLPELLERLELPAVLGGRRSERETLSYVHADNAGGARAAVRHLLSRGRTAIGTVTGPLDIEGAAARLAGYRQALAEAAVPADEGLVAHGDFTERGGREGMRELLARRPGLDAVFCASDLMAAGALQALREAGRRVPQDVAVVGFDDSVVARHTEPPLTSVRQPIEETGRLMVRSLLKEIAQPGRFRRQTVLPTELVVRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG7</accession>
    <name>A0A1E7NGG7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kanamycin biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3588"/>
    <dbReference type="EnsemblBacteria" id="ARF83151">
        <property type="protein sequence ID" value="ARF83151"/>
        <property type="gene ID" value="B6264_29480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39800">
        <property type="protein sequence ID" value="OEV39800"/>
        <property type="gene ID" value="HS99_0000615"/>
    </dbReference>
    <dbReference type="OMA" id="GHEDQAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="58" mass="6629" checksum="EAFA5B46554F66C6" modified="2017-01-18" version="1">MSMLDKLKNMLKGHEDQAEKGVDKAGDTFDERTQGKYSSQTDVAQDKLKDQFRDQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP3</accession>
    <name>A0A1E7NGP3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6697"/>
    <dbReference type="EnsemblBacteria" id="OEV39847">
        <property type="protein sequence ID" value="OEV39847"/>
        <property type="gene ID" value="HS99_0002625"/>
    </dbReference>
    <dbReference type="OMA" id="GGEWFAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018681">
        <property type="entry name" value="DUF2165_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09933">
        <property type="entry name" value="DUF2165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17753" checksum="BD9F163536617EE7" modified="2017-01-18" version="1">MLELGSPRAAAAVLTGTNALYLLLVVFGNVTDFATNQQFVQHVLAMDTTFRDQDLMWRAVTSPGLQNAAYVAIIAWEALSALVLTAGTFAWWLRPAVARRLSTLGLLLMLLLFGAGFIGIGGEWFAMWQSKAWNGLDAAIRNVTLAGLALVVVNLPHRTRAPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGR9</accession>
    <name>A0A1E7NGR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2941"/>
    <dbReference type="EnsemblBacteria" id="OEV39877">
        <property type="protein sequence ID" value="OEV39877"/>
        <property type="gene ID" value="HS99_0003720"/>
    </dbReference>
    <dbReference type="OMA" id="GLWYAFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="89"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="242"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="574" mass="61680" checksum="79F8AE059AB0C161" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV60</accession>
    <name>A0A1E7MV60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289819.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6906"/>
    <dbReference type="EnsemblBacteria" id="OEV32320">
        <property type="protein sequence ID" value="OEV32320"/>
        <property type="gene ID" value="HS99_0016580"/>
    </dbReference>
    <dbReference type="OMA" id="IYLSHDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16071" checksum="6D779C62F4A97C67" modified="2017-01-18" version="1">MAITDPLRRGTGLVLRNVRTGRFQRSLALATGVGSVITAAEIYLEHDRAGFGNRVMWWPVWLGPVGAVAGVAGALSPRAARTLLPVASASIVANGLQGTWLHVRGIAEKPGGWEMARYNVEMGPPLFAPLLMSFVGGMGLVAAVLRRESPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV80</accession>
    <name>A0A1E7MV80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553795.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000621.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6916"/>
    <dbReference type="EnsemblBacteria" id="OEV32328">
        <property type="protein sequence ID" value="OEV32328"/>
        <property type="gene ID" value="HS99_0016630"/>
    </dbReference>
    <dbReference type="OMA" id="ITVSYWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13732" checksum="ED78EF9971983FF1" modified="2017-01-18" version="1">MSDHPEAPAVPVEAFEPPYYVAVFTAVRTPDQSGYSETDARMKELVRDIPGYLGMDYAQSPGGLAITVGYFRDAEALAAWRTDVEHRAAQQRGRAEWYQRYSLHVAKVERSHGFVRTEAPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD3</accession>
    <name>A0A1E7MVD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480867.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6991"/>
    <dbReference type="EnsemblBacteria" id="OEV32392">
        <property type="protein sequence ID" value="OEV32392"/>
        <property type="gene ID" value="HS99_0017005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="802" mass="85841" checksum="65462E2E20BA5AF1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVF4</accession>
    <name>A0A1E7MVF4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32405">
        <property type="protein sequence ID" value="OEV32405"/>
        <property type="gene ID" value="HS99_0017075"/>
    </dbReference>
    <dbReference type="OMA" id="GLYADWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="31346" checksum="5DCCBC18ADE3564E" modified="2017-01-18" version="1">MANTSMITSSLGDYLRARRALVSPADAGLPETGRRRVPGLRREEVAELVGLSADYYVRLEQGRADRPSDEVLDALGRALRLGPAERAHLYDLARPPRRASAKAATAGRGEALRPALRQIVEAIPVTPALIMNDRNDVLAWNRPAAALIADFPRLAPPERNMARRIFLDPDAREVHLDWDEAARTTVGILRMAAGRHPHDPELVRLVGELSLGSETFRRLWAGHHVHEKNHGPKRFRHPSVGEVTLDYETFHVPGAAHHLLVVYTAPPGSPAEEALHLLGSLTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVJ3</accession>
    <name>A0A1E7MVJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831553.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1190"/>
    <dbReference type="EnsemblBacteria" id="OEV32445">
        <property type="protein sequence ID" value="OEV32445"/>
        <property type="gene ID" value="HS99_0017335"/>
    </dbReference>
    <dbReference type="OMA" id="CGCVVWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7886" checksum="7614A2C516D5F38C" modified="2017-01-18" version="1">MVGAVLVGVLVLVLAGCGCVVWAERGGPRWARAVAALTLAAGDLLRSAEQRRRRRERRERWLLGKGGSGESSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP2</accession>
    <name>A0A1E7MVP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2965"/>
    <dbReference type="EnsemblBacteria" id="OEV32501">
        <property type="protein sequence ID" value="OEV32501"/>
        <property type="gene ID" value="HS99_0016215"/>
    </dbReference>
    <dbReference type="OMA" id="ILFWLSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="28180" checksum="00E961C2D20FACC3" modified="2017-01-18" version="1">MGIAAMVLGIVGTALSLAVILFWLSWLPALLALVFGFIGLGYARRGVATNRGMALAGVVLGITGLVVSIGAGVFVVARVHTVNEERRAEADAARARADAEQRAADERLAKAKERLEAARKKAEADRRAAAADERARRLSFGQSYTYGDGLKVTMAAPEPYVPSRTVFEPPKDATIVQVKITVVNTGSKEVSLHGSGLPFVHDAKGGLVTTLIDGSDRMKILGGSLAPGQDATGVSAYALPNGAADTFSVEFDYGSGLERKNVIWTGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV7</accession>
    <name>A0A1E7MVV7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32403">
        <property type="protein sequence ID" value="OEV32403"/>
        <property type="gene ID" value="HS99_0017060"/>
    </dbReference>
    <dbReference type="OMA" id="LVACSCI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13309" checksum="BAD27F82F82582CF" modified="2017-01-18" version="1">MGPVARPFLVRGRAVPLARYLAEEGIEGLVACSCIGNEVTIDLADTRILVSLADVGGVVGLTFHMVQDGPAKARSWTRRLPSDTAPRELAASIARDVRTLERELAPLRRRPPEGTERRWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVY3</accession>
    <name>A0A1E7MVY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289060.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000942.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3804"/>
    <dbReference type="EnsemblBacteria" id="ARF78374">
        <property type="protein sequence ID" value="ARF78374"/>
        <property type="gene ID" value="B6264_05065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32588">
        <property type="protein sequence ID" value="OEV32588"/>
        <property type="gene ID" value="HS99_0015015"/>
    </dbReference>
    <dbReference type="OMA" id="EMVIGPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="22605" checksum="0098DA21CFEC4E93" modified="2017-01-18" version="1">MTHGTTSPHPAEPAPAPRRGRPRDAARDRALLDATLAVLAENGYGGLTTAAVAARAGVSTATLYRRWSSKEELVIAAAALHGESSYEQPGTGTLEGDLRVVLREKAAAMTGEPGRLIRALIGEAAHNTALAEALVTAFLQPLYDRVAEVVRRAVERGEIPPLDGVELLGEVVVGPVMTHFLLTPRLPEDVDQATARETADRLLPFALRAVGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVY4</accession>
    <name>A0A1E7MVY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-oxalocrotonate tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287947.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000114.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3808"/>
    <dbReference type="EnsemblBacteria" id="ARF78370">
        <property type="protein sequence ID" value="ARF78370"/>
        <property type="gene ID" value="B6264_05045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32592">
        <property type="protein sequence ID" value="OEV32592"/>
        <property type="gene ID" value="HS99_0015035"/>
    </dbReference>
    <dbReference type="OMA" id="VQVWIHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6842" checksum="16A0528C216424BD" modified="2017-01-18" version="1">MPIVTIQQGPRNVEQKRELVKKVTEAFVEALEVPAESVYVWIQEYQPENWGAAGKLTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD2</accession>
    <name>A0A1E7MWD2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285540.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000387.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7820"/>
    <dbReference type="EnsemblBacteria" id="ARF78212">
        <property type="protein sequence ID" value="ARF78212"/>
        <property type="gene ID" value="B6264_04145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32745">
        <property type="protein sequence ID" value="OEV32745"/>
        <property type="gene ID" value="HS99_0015940"/>
    </dbReference>
    <dbReference type="OMA" id="DRRPNAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="37463" checksum="0226BF7C0B389A0C" modified="2017-01-18" version="1">MAIKAEYIWIDGTKPTAKLRSKTRVLPNADKIPTWGFDGSSTNQAEGHASDRVLEPVKVVKDPIRGGDNILVLCEVLETNGTPHESNTRALLREVEEKYTAQESIFGIEQEYTFFKGSRPLGFPEGGFPAPQGGYYCGVGAEEVFGREIVELHLDRCIDAGLAICGINAEVMPGQWEFQIGPVDALTVSDDLWIARYLLYRTAEEFGIDATLDAKPARGDWNGAGAHTNFSTKAMREGYDAIITACESLGASQEKVLEHVTQYGADIESRLTGKHETAPWNVYSYGVSNRGASVRIPWQVEVEQKGYIEDRRPNANVDPYVVTRLLINTCCEALEKAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG6</accession>
    <name>A0A1E7MWG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285613.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6096"/>
    <dbReference type="EnsemblBacteria" id="ARF78183">
        <property type="protein sequence ID" value="ARF78183"/>
        <property type="gene ID" value="B6264_03965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32771">
        <property type="protein sequence ID" value="OEV32771"/>
        <property type="gene ID" value="HS99_0016115"/>
    </dbReference>
    <dbReference type="OMA" id="QADNPGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="51618" checksum="A85AC5E711BA4B77" modified="2017-01-18" version="1">MRVPRISRTRYAAVGLVLATAGALALPAGTAVAAPTGDSTTGPLLSYVVNTKANHGQVQKVEKAITGLGGTVVQSYEQVGVVVARSNDTKFAEKLRLAKGVDSVGASRTKGILASDQGNADVAAEPTGAAAAADGQEPYEPNQWDMRQIGVDKAHKLSLGSRNVTVGVLDSGIDATHEDLAANVDASQSVSCIDGRTNTDWKAWQPTTSDHGTHVAGTIAAAKNGKGVIGIAPNVKLAAVKVVDDGGFIYPENAVCGFVWAGEHGFKVTNNSYYVDPWMFNCPNDKDQAAISDAIRKAVAFSQRKGVLNVAAAGNENIDLAHKTTDVSSPDDTKPGSRPITNDCLSLPTELPGVVAVSAVGVNGDKSYYSSYGKGVVTVAAPGGDARYQIPNTPDKNGRILSTIRGNKYGYMQGTSMATPHVTGVVALLASTFPWASPDELTELLTNQAESHACPKGVYNPGNTGQFTATCEGGADDNGFYGAGIINAEKAVQWWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWK2</accession>
    <name>A0A1E7MWK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7825"/>
    <dbReference type="EnsemblBacteria" id="OEV32808">
        <property type="protein sequence ID" value="OEV32808"/>
        <property type="gene ID" value="HS99_0015915"/>
    </dbReference>
    <dbReference type="OMA" id="PCTATIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="530" mass="55921" checksum="5A0A0B33EF8879AC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV1</accession>
    <name>A0A1E7MWV1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0039500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000077">
        <property type="protein sequence ID" value="OEV32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738004.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000113_gene3868"/>
    <dbReference type="EnsemblBacteria" id="OEV32908">
        <property type="protein sequence ID" value="OEV32908"/>
        <property type="gene ID" value="HS99_0039500"/>
    </dbReference>
    <dbReference type="OMA" id="VQVWPEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1588"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2787"/>
            <end position="2810"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1623"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="2810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2810" mass="291226" checksum="79E3939F8D9F9374" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX29</accession>
    <name>A0A1E7MX29_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0014065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279876.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000645.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5707"/>
    <dbReference type="EnsemblBacteria" id="ARF81412">
        <property type="protein sequence ID" value="ARF81412"/>
        <property type="gene ID" value="B6264_23095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32996">
        <property type="protein sequence ID" value="OEV32996"/>
        <property type="gene ID" value="HS99_0014065"/>
    </dbReference>
    <dbReference type="OMA" id="PWGGSAY"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="733" mass="79562" checksum="93D34F69ED58CAF9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX30</accession>
    <name>A0A1E7MX30_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanosine monophosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0013900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5740"/>
    <dbReference type="EnsemblBacteria" id="ARF81383">
        <property type="protein sequence ID" value="ARF81383"/>
        <property type="gene ID" value="B6264_22930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32969">
        <property type="protein sequence ID" value="OEV32969"/>
        <property type="gene ID" value="HS99_0013900"/>
    </dbReference>
    <dbReference type="OMA" id="HDYHMTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Thioimidate intermediate" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="498" mass="53643" checksum="C8B05648D0650E58" modified="2017-01-18" version="1">MAQIIAEVSRTFNEYLLLPNRTRTDCRPAAVDLRTPLVRHRAGEASAIELHAPFASAIMQAVSSPELAIALARNGGLSFIHHNQSIEEQAAAVRKVKNFKAGFVTSDTNVRPDDSLRDLVGLMGRTGHSTAAVTHDGSATGRLLGLVTSRDFHPQRHDLEGPVSGRMTAVGDLPHAGVDVTLSEANARLWEERLDCLPVLDDEGHLQHLVFRSDYADNKRFPNQVVDADKRLRVGAGVNTHDYRDRVPALLEAGADVLCFDSSDGYSDWQAEALTWTKKHYPEIPIGGGNVVDGEAFTFLAEAGADFVKIGVGGGSICITRDQKGIGRGQASAVLDVAAARDAFLERTGDYVPLCSDGGLVEDYHVALALAMGADFVMMGRYFARFDQAPGAKIPTRDGFVKEYWGEGSNRARNWQRYGQGGQGLVFEEGVDGYVPYAGDLNEGLATTIAKIKSTMVSCGSVTLPEFQSSARLTLVSEQSLQESHASVALRDTSGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA0</accession>
    <name>A0A1E7MXA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0039750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289951.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene78"/>
    <dbReference type="EnsemblBacteria" id="ARF80126">
        <property type="protein sequence ID" value="ARF80126"/>
        <property type="gene ID" value="B6264_15435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32863">
        <property type="protein sequence ID" value="OEV32863"/>
        <property type="gene ID" value="HS99_0039750"/>
    </dbReference>
    <dbReference type="OMA" id="HMRTLHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="33766" checksum="FC7BE9B993A5E55B" modified="2017-01-18" version="1">MSTEGGTRALVAALSANLAIAAAKFAAFGFTGSSSMLAEGVHSVADSGNQVLLLIGGRRARRAADEEHPFGYGRERYIYGFLVAIVLFSVGGLFAVYEGWHKVNHPEALESWGWAVGVLLFAVAMEGWSFLTAVRESAKAKGGQGWVQYIRTAKAPELPVVLLEDTGALIGLVLALLGVSLTVVTGNGVWDGVGTLCIGVLLVLIAVVLALETKSLLLGESADRESVRRIRAALVDGEAVTGVIHMRTLHLGPEELLVAAKIAVNAEDSAARVALAIDAAEERVRAAVPIARAIYLEPDVYSAEKAAAGEDPAATPGGPGPAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY07</accession>
    <name>A0A1E7MY07_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597856.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000912.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7039"/>
    <dbReference type="EnsemblBacteria" id="ARF80431">
        <property type="protein sequence ID" value="ARF80431"/>
        <property type="gene ID" value="B6264_17315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33330">
        <property type="protein sequence ID" value="OEV33330"/>
        <property type="gene ID" value="HS99_0012085"/>
    </dbReference>
    <dbReference type="OMA" id="GALRHWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063893" evidence="2">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="28348" checksum="C556CFAEAABF73BE" modified="2017-01-18" version="1">MDVFGVMIGLVLLFGIATLVLAVVGTVKAAKAVAAKVEKHEANARRAVETATLKAKTYTKVGPPAQIASVRLKLRTSLDGTRQVLEGGLAQDGQLGESLALLTRLDAHAAELDGELRVLEREPDTARVAAKLPELRERAERITHAAETMRWAAQDRMHRFADDELSRLSQECESEAGALRHWDTGAGSGSASGAASGTAAASAAASAAASGGGSAGVGGAAGAAGSSGGGAGSSGGGAVRAGLTDGKGRPSAEDLLGLADPLTKLAQRLRKPSTGPSAGPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY30</accession>
    <name>A0A1E7MY30_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5757"/>
    <dbReference type="EnsemblBacteria" id="OEV33143">
        <property type="protein sequence ID" value="OEV33143"/>
        <property type="gene ID" value="HS99_0013820"/>
    </dbReference>
    <dbReference type="OMA" id="ARTERYC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16419" checksum="771CDD64BC7055A8" modified="2017-01-18" version="1">MIVGLSGSLSSLAALYHSVGEAARHGAVLVPVAAWTVGDRDGLRPRSELEHAARRRLDVAFGQAYGGYPSGLVIRPLVVNSEPGPALVAAVTGPEDLLVLGAPTRRRFDRLRGTSVARYCRHRAGCRVVEVSPSALLTRLELPARTGAPLPLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC4</accession>
    <name>A0A1E7MYC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0012740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6573"/>
    <dbReference type="EnsemblBacteria" id="OEV33437">
        <property type="protein sequence ID" value="OEV33437"/>
        <property type="gene ID" value="HS99_0012740"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="41602" checksum="B563930C8AD34800" modified="2017-01-18" version="1">MVALAVGGVLLMSAACGDGDGRDKGADAAGPVTSATPATPGAPGGTAATAAPKTSTAVLDVEPKDGARGVAPTALQVSVSHGKLTAVDVTDKDGKPVQGSITADGTGWKPAAALAPGVAYTVNAQAKDAEGLIAAATSAFTTALPGKQVSTDDNIADGHTYGVGMIVKVEFSSGIVNKDAVAKAITFETDNGTEVKGHWFGDNRIDFRPADYWKPNTKVTVHYRLKNVEVAPGVWGDVDKDEPFTIGRSQVTTADAAAHQMTIRRDGKSTTVPATLGDDKHPSWGGTMVIMSKEKVTHMNSQTVGLGDEYDIPDAPHAMRLTTSGTYVHGNYWYKVDLFGKANTSHGCVSLKDVEGGSDTSPAGSFFNSSLIGDVVTVVNTKEKTVSPDNGLGGWNVSWANW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE7</accession>
    <name>A0A1E7MYE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555517.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6579"/>
    <dbReference type="EnsemblBacteria" id="ARF80548">
        <property type="protein sequence ID" value="ARF80548"/>
        <property type="gene ID" value="B6264_18000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33444">
        <property type="protein sequence ID" value="OEV33444"/>
        <property type="gene ID" value="HS99_0012775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="809" mass="88581" checksum="8B49E1A38D765F2B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYG8</accession>
    <name>A0A1E7MYG8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6623"/>
    <dbReference type="EnsemblBacteria" id="ARF80582">
        <property type="protein sequence ID" value="ARF80582"/>
        <property type="gene ID" value="B6264_18210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33478">
        <property type="protein sequence ID" value="OEV33478"/>
        <property type="gene ID" value="HS99_0012990"/>
    </dbReference>
    <dbReference type="OMA" id="CYGQFES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="45027" checksum="132E315593CC7090" modified="2017-01-18" version="1">MCTVTGTVKQQRQQRRGAGGPLRRVQIGNALSAFGSGFTMPYMFVYVDQVRGLGSLAAGMVFTVFALAALAVLPFTGRGIDRYGPRPVLLAGAGLAGTGAFAFGHATGTPTLLVSSFLFGAGVTTCQPALATMIVRCSTAATRSHAFALQFTLVNLGMGIGALVGGQIVNVADPASLTRLFTIEAATFLGLALVTGTARIPTAQLSVVQGKNDGPTGLRALFADKAMVRLSILAGLIFFTCYGQFESGVAAFATDTVGTAPSTLGFAIGANAVTIVVLQMFMVRITARRRRTTAMAAAGLVWLGAWAMALVAGLIRTEAMAATVAIVSIYALFGVGESLLAPTMGPIVADLAPARLLGTYNAGYALVKQIAIAIGPAVGVLLVGSGTWPLYLAAMAGSTLLIVLLALRLRPYLTAEQDNAAPAVVRTPAPVRELQTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS6</accession>
    <name>A0A1E7MYS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033349027.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82890">
        <property type="protein sequence ID" value="ARF82890"/>
        <property type="gene ID" value="B6264_17715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33587">
        <property type="protein sequence ID" value="OEV33587"/>
        <property type="gene ID" value="HS99_0012490"/>
    </dbReference>
    <dbReference type="OMA" id="FAGKAYH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10580" checksum="CA53298E052CC08F" modified="2017-01-18" version="1">MMWKLSLAVGFAAGYVLGSRAGRQRYEQISKVTRQIARNPAVQGAADRARQQAGAVAGKAAGAVADRVGDRLPNAVTDRVPYFSRSRTEDDGWGTFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ02</accession>
    <name>A0A1E7MZ02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386291.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000303.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4930"/>
    <dbReference type="EnsemblBacteria" id="ARF79999">
        <property type="protein sequence ID" value="ARF79999"/>
        <property type="gene ID" value="B6264_14745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33662">
        <property type="protein sequence ID" value="OEV33662"/>
        <property type="gene ID" value="HS99_0038415"/>
    </dbReference>
    <dbReference type="OMA" id="DIDWNRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42986" checksum="D7619E49FBA1C9F7" modified="2017-01-18" version="1">MATTTDERLRRWRLVLGGEADGTGCTLRGRDAAMDGALAALYRGAPDDAARTGRGRRSAGLGGSAPQVARWLGDIREYFPSTVVQLMQQDAITRLGLDRLLLEPEMLEAVEPDVHLVGTLLSLKHALPETTRETARAVVGKVVADLERRLADRTRATLGGALDRSARVNRPRHRDIDWDRTIRANLKNYLPEHGTVVPERLVGYARAQRAVKKDVILCVDQSGSMAPSVVHSAVFGAVLSSMRTLDTRLVVFDTSVVDLTEQLTDPVDVLFATQLGGGTDINRALAYCQSRITRPSETIVVLISDLYEGGIRDGMLRRVAAMKAADVQFIALLALSDEGAPAYDHAHAAALAALGAPAFACTPDVFPEIMAAAIEKRPIPQHLVKGADRGEAQLHSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ04</accession>
    <name>A0A1E7MZ04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555529.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80557">
        <property type="protein sequence ID" value="ARF80557"/>
        <property type="gene ID" value="B6264_18045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33453">
        <property type="protein sequence ID" value="OEV33453"/>
        <property type="gene ID" value="HS99_0012825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6457" checksum="46D1A48C48FE4555" modified="2017-01-18" version="1">MGNSQHHPLSGDGREGEQPLRRLLKSVLGSAPAPIPDLSDEELVAEVRKASAEGGPERASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZT7</accession>
    <name>A0A1E7MZT7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280323.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000829.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2170"/>
    <dbReference type="EnsemblBacteria" id="ARF77802">
        <property type="protein sequence ID" value="ARF77802"/>
        <property type="gene ID" value="B6264_01665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33949">
        <property type="protein sequence ID" value="OEV33949"/>
        <property type="gene ID" value="HS99_0010825"/>
    </dbReference>
    <dbReference type="OMA" id="HPQMIAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041478">
        <property type="entry name" value="TetR_C_27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17935">
        <property type="entry name" value="TetR_C_27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="21740" checksum="8F353BD57BB31EC1" modified="2017-01-18" version="1">MTTDTALTAEQILIAAEEVLRRFGPAKATVVDVARELGVSHSSVYRHFPSKAALREAVTQRWLDQAHFELKAVMDDSGGAAERLERWLTTLFAAKRKKALDDPELFATYMVLVEENSRTVEEHIDTLVTQIAEIFQDGVDGREFKPAHVLTTARAVFDATAPFHDPAYASTWAEPTADERFRAVWKLVLGGLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU2</accession>
    <name>A0A1E7MZU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine/betaine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280297.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2183"/>
    <dbReference type="EnsemblBacteria" id="ARF77815">
        <property type="protein sequence ID" value="ARF77815"/>
        <property type="gene ID" value="B6264_01735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33960">
        <property type="protein sequence ID" value="OEV33960"/>
        <property type="gene ID" value="HS99_0010890"/>
    </dbReference>
    <dbReference type="OMA" id="KDPAWKN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="32174" checksum="A9D4A3B833600409" modified="2017-01-18" version="1">MNRSRRAVLLGTLAALALGATACGSSASSSNPLGGGSSAAASGAGSTAGGGSGGTVVVGSANFPENVLLGSIYSQALKAKGVNVEEKFNIGSREVIYGQLQSGNLTVLPEYNGSLLAYLDAKNTAVTTQDVNAALAKALPSSLAVLDSSPAEDKDSLSVAQETADKYNLKSISDLAAKAGEFTIGGPPEFKSRREQQFKDVYGLTFKEWKPTADTTANALKDGSIQVGNVFTTDPKIVQYKLVALSDPKNVFGAQNITPLVNKAGLDATATAALNAVSAKLDTAGLTGLMKRVSVDKEDPSTVARDWLKANGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N049</accession>
    <name>A0A1E7N049_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366481.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2321"/>
    <dbReference type="EnsemblBacteria" id="ARF77926">
        <property type="protein sequence ID" value="ARF77926"/>
        <property type="gene ID" value="B6264_02405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34068">
        <property type="protein sequence ID" value="OEV34068"/>
        <property type="gene ID" value="HS99_0011555"/>
    </dbReference>
    <dbReference type="OMA" id="EPPYEGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12638" checksum="B3C1E6A5F4B8DF4E" modified="2017-01-18" version="1">MTLPLPSCRAHGPGLDCAALVGRRSVRLASGTDRCLMVDAEPPYEGYDMGDWGRIEVLPADTGSAFDAHLGEPVLAIRDECEQMTGRMALELDFPSGTVRCESYGGELIVRAVLTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N085</accession>
    <name>A0A1E7N085_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551896.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2360"/>
    <dbReference type="EnsemblBacteria" id="OEV34099">
        <property type="protein sequence ID" value="OEV34099"/>
        <property type="gene ID" value="HS99_0011735"/>
    </dbReference>
    <dbReference type="OMA" id="SETEMFS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="10025" checksum="7F6333B141604070" modified="2017-01-18" version="1">MVEECGPWLASLPDASWELYPPQRRAAAALDWDPVHGDRVQQLCFTAEGLDADGIVELLDSCLLTDEELASGEEGWKHLPDAFDDMLDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N118</accession>
    <name>A0A1E7N118_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283354.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3913"/>
    <dbReference type="EnsemblBacteria" id="OEV34387">
        <property type="protein sequence ID" value="OEV34387"/>
        <property type="gene ID" value="HS99_0036175"/>
    </dbReference>
    <dbReference type="OMA" id="MVHALHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="27065" checksum="634B32FC7531F08F" modified="2017-01-18" version="1">MESGYLVLPGLLPEALRERLVPEVDRWVDEGLRARSIAACTDPDRHGPPPLLELELPAHGELLAHPPLLLALTGLIGPSFVFHHLHSDRQSPGIPGKPWHHDCEPHDGSDPSLLMVHALHYLGGLDAKVGSLAVLPGSHRHAAGKDAYAHHGTAELPGEVVLDRLPPGTTVLLNSALFHTRRPAPEGPGHPRYFIDASYCQVGARWRPVKPHWRLMLARARELDLADGQWPELFAEHHFTEYTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N146</accession>
    <name>A0A1E7N146_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7192"/>
    <dbReference type="EnsemblBacteria" id="OEV34391">
        <property type="protein sequence ID" value="OEV34391"/>
        <property type="gene ID" value="HS99_0035860"/>
    </dbReference>
    <dbReference type="OMA" id="GIWSALN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="114"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="27285" checksum="F1E537D40C44ABBA" modified="2017-01-18" version="1">MPAPAPPTPAPTSAAPAPVPVPAAPERPAPSPSASPSPKPTPKQIPPPVATRAPRHEPTPEPTTEAPVVPIPAPAPALPALPTLPPLPTPEVPVVPTPTVPPVPEPTVTPPGPPAPTGFWGDSLPVWKPGNHRVPPEGPSIRRKGSDRFWQRDGGWIGGDYHPHAITVHAPATTLVDLNRSCTSFDAVAGVDDATLSPGGVVFTVQSGDGSTLWRSRPIGAGDDAVPVHVPLAGQKSIRLVVTPVHGIWSALNVADWAQARFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G1</accession>
    <name>A0A1E7N1G1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0035595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2563"/>
    <dbReference type="EnsemblBacteria" id="OEV34528">
        <property type="protein sequence ID" value="OEV34528"/>
        <property type="gene ID" value="HS99_0035595"/>
    </dbReference>
    <dbReference type="OMA" id="HDDLEME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10934" checksum="CB7991B3995EC273" modified="2017-01-18" version="1">MRPPTEPEVLAELAGMLTVVLDDCGLGDAEVTMQTRFTEDLGLESIDLVTLAGQLRERWGDRINFAEFVAGMELDEIIGLTVGRLVEYVVDRLQPGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H2</accession>
    <name>A0A1E7N1H2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285313.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7645"/>
    <dbReference type="EnsemblBacteria" id="ARF82652">
        <property type="protein sequence ID" value="ARF82652"/>
        <property type="gene ID" value="B6264_05745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34313">
        <property type="protein sequence ID" value="OEV34313"/>
        <property type="gene ID" value="HS99_0036635"/>
    </dbReference>
    <dbReference type="OMA" id="SGRAPWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="23077" checksum="6C8E35E2B60D4BF0" modified="2017-01-18" version="1">MLVAAAVCPCPPLLVPEVAAGAAPELDALRAACDEALAALVAAEPQLVVAVGAGPEAEVWTEGGAGSFHRYGVPLIAKLPGGRVEGPELAPSLTVGAWLLERAGVTLPTHACAVPADAPADRMLGLGQGLAGLADRVALLVLGDGSACRSLKAPGYLDERAEGFDTSLAAALGSADLPALAAVDPALAAELKAEGRAPWQVLAGAAEGAGLTARLGYQDAPYGVGYFVASWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H5</accession>
    <name>A0A1E7N1H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6121"/>
    <dbReference type="EnsemblBacteria" id="ARF79320">
        <property type="protein sequence ID" value="ARF79320"/>
        <property type="gene ID" value="B6264_10670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34534">
        <property type="protein sequence ID" value="OEV34534"/>
        <property type="gene ID" value="HS99_0035150"/>
    </dbReference>
    <dbReference type="OMA" id="TRAACHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="35007" checksum="CD05D5CD76A9531D" modified="2017-01-18" version="1">MSPSTIHRDAPLITAWSAVSPFGLGREAFAAGVGRGEPAHEVPDFDTRKVLGKAGTRTFDRATGLAVTAVRELLDEAEAAQSPIATGGGTALVLGTTLGSAHSSAGFSRASFEGDKPYDVPAQLMPNVLMNGPAAATAIRFDLKGPNTTLAGGAAGGLLALGYARRLLAADRAERAVVGAVEEQSTTREWLAGLAEQPLGEGSVVLLMETARTLPPGRRVLAELLALDVRLDIDDDPARALADVVREALDQAGATPDEVWAAAVTGQPARDQLAALVGAEAVDRVPALFGDTGSAGTVFSLTTVLSLAEHDPTATGRVAVIASLDHQGLAACAVLRLTGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1R4</accession>
    <name>A0A1E7N1R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554744.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000470.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4275"/>
    <dbReference type="EnsemblBacteria" id="ARF82011">
        <property type="protein sequence ID" value="ARF82011"/>
        <property type="gene ID" value="B6264_26800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34624">
        <property type="protein sequence ID" value="OEV34624"/>
        <property type="gene ID" value="HS99_0008995"/>
    </dbReference>
    <dbReference type="OMA" id="DERVAWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="17159" checksum="D175CE73CBAF3B1C" modified="2017-01-18" version="1">MSRVQETIDVDVPVSTAYNQWTQFEQFPMFMEGVEEITQIDDRHNHWKTKIAGVSREFDTEIVDQVPDDHVAWRTVTGEVKQSGMVSFQPLDASHTRIVMSMDYQPEGLAEKAADMMNMLDRQVKGDLKRFKNFIEKRGAETGGYRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N241</accession>
    <name>A0A1E7N241_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555827.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81878">
        <property type="protein sequence ID" value="ARF81878"/>
        <property type="gene ID" value="B6264_25985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34759">
        <property type="protein sequence ID" value="OEV34759"/>
        <property type="gene ID" value="HS99_0009775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7413" checksum="7F9E79B4FADF1A2C" modified="2017-01-18" version="1">MHRSAGRSFRPHRGRPAPLTLAGNLWRNNVTGDTYSSATTRRSMAGATLVEVARVDNPAALIAPRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H8</accession>
    <name>A0A1E7N2H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7628"/>
    <dbReference type="EnsemblBacteria" id="OEV34894">
        <property type="protein sequence ID" value="OEV34894"/>
        <property type="gene ID" value="HS99_0010220"/>
    </dbReference>
    <dbReference type="OMA" id="VNCGHAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="36198" checksum="17630ACE6FED4F85" modified="2017-01-18" version="1">MARWSHGVTIGGYVLVAVAVALDLASGPDVTFAPMLAALPVLAGVGVRRASVPLAAGAVACAIVVGLAAYDADVPAVVMATAAATVVVVTFFSCANVAVVTAQERELARVRTVAEAAQRALLRLVPRRMGPLVVAVRYVAAEAEARIGGDLYEVMPTPYGVRLFLGDVCGKGLAAVETAADVLGVFREAARAEPDLAKVAGRLDSALVRRPASEEFVTAVLVSIPDAPGPAVVVNCGHPPPLLCHDGQVSTVEPPVEAPPLALLGLVGGDYHARSIAFERRDLLLLYTDGVSEARDTANRFYPLAQRLAALPHGEPDALLDELLLDVRAYVGSGLTDDAALLAVRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P1</accession>
    <name>A0A1E7N2P1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288635.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5894"/>
    <dbReference type="EnsemblBacteria" id="ARF82061">
        <property type="protein sequence ID" value="ARF82061"/>
        <property type="gene ID" value="B6264_27100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34935">
        <property type="protein sequence ID" value="OEV34935"/>
        <property type="gene ID" value="HS99_0035085"/>
    </dbReference>
    <dbReference type="OMA" id="TDENRWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19319" checksum="D2F407DBDFFC16A5" modified="2017-01-18" version="1">MLKLAILGFLYDRPLHGYELRRHLAALTGHVRPISDGSLYPAIKRLEADGLLVRETEPGSAAAPRHTLHLTGAGRTALLDRLRAPEPLDISDGNRWTALVSFLRHLDDPAAQAAVLRRRIAFLSEPASFFYEGDRPRAAEEFTDPFRRGLLLTARATTEAELSWLRAAVDELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q4</accession>
    <name>A0A1E7N2Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598790.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5899"/>
    <dbReference type="EnsemblBacteria" id="ARF83095">
        <property type="protein sequence ID" value="ARF83095"/>
        <property type="gene ID" value="B6264_27125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34950">
        <property type="protein sequence ID" value="OEV34950"/>
        <property type="gene ID" value="HS99_0035110"/>
    </dbReference>
    <dbReference type="OMA" id="YRTVQYS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="494" mass="54023" checksum="4555C163AEAB0D8B" modified="2017-01-18" version="1">MPAPRPAPGPAADEGLARRLKALACTAPLHDLDNRKVNLAGEYGGYAMAEVGLAAIDLVTLNMDFDTGADRETVLARMLPRVAAQAPHRHALEHERVARWVLESLINVGSVDRGFRAVYGTFGPDGEYVRRDYDFKLIEEVPGPDGGVYLRTTDEAVNVLVGALDTDVTSAQIAAEVKLEVLIRRGRLADAQLAAEQARYRTVQYAETLRRALDATRRNVRAVDWMKAVPDLIDEALDHIADRYRHENAILTNIRKARDEAEDPEHKRRAAELVDIVKDCIRRHTQLQTRLLEAGPLFRAEQDRQAFATPGARSGIDLYGQLLAPVLRLPVEQAVRPTGAFFARGAGLRTPVSVRVADLVDLLLTPPVEREHLGAELPDPDLVATPDDSRFSEAQLESALELLDLPPDAPRRLSGLLADARKRDPELPYLVALLAVHAASPPVGTAYRQGEERLLFAVDDGTPLRDREFGGADLIVGSALLDAVGMAADRKDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N325</accession>
    <name>A0A1E7N325_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386360.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene388"/>
    <dbReference type="EnsemblBacteria" id="ARF78912">
        <property type="protein sequence ID" value="ARF78912"/>
        <property type="gene ID" value="B6264_08270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35109">
        <property type="protein sequence ID" value="OEV35109"/>
        <property type="gene ID" value="HS99_0034180"/>
    </dbReference>
    <dbReference type="OMA" id="ETSLYWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="24289" checksum="39F49489E0BE4816" modified="2017-01-18" version="1">MTPEQPNAILPDAPTNPVQALLEAPLSLRERKKLKTRQTVRREAYRLFVEQGYENTTVEQIAAAAEVSPSTFFRYFATKEDLVLTDEYDPAMIASLMARPAGEPFLRSCRETLIGLIRTLLQHERQELLTRMRLVTQVPALRAGLFRIGNSPHELYLDVLTRRAGLDEPTYDMRVTAAAIGAATTEAVLQWAAGDGREDIADLVDRTFALLESGFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N373</accession>
    <name>A0A1E7N373_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="13" type="ORF">HS99_0034880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000839.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5852"/>
    <dbReference type="EnsemblBacteria" id="OEV34903">
        <property type="protein sequence ID" value="OEV34903"/>
        <property type="gene ID" value="HS99_0034880"/>
    </dbReference>
    <dbReference type="OMA" id="AMDSIPF"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="8"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="29740" checksum="7C9647D7499E3F6B" modified="2017-01-18" version="1">MKLLPAGRVIVIGSVNTDRILRCPVLPAPGETVLAADATLGFGGKGGSQAVAAARMGAATHLVAKVGRDADGEAALADLRGAQIETGAVHTHPDAPTGQAIVMVEPGGENSIVVVPGANARLTPEEVTAALARLHLLPVDVVLTSNEVPAECIRATAAALPAAGPNGGTRWLHNTAPAGDLPGPGPTGRRPLVVANAVEARQLTGAATATEAARALARLAEGAVVTLGGEGAVVVTGEGLTRLPAPAVQVVDTTGAGDVFCGALAARLARGAALAEAAATAVAAGAFAVTALGARGALPRPADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J5</accession>
    <name>A0A1E7N3J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6136"/>
    <dbReference type="EnsemblBacteria" id="ARF79305">
        <property type="protein sequence ID" value="ARF79305"/>
        <property type="gene ID" value="B6264_10595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35242">
        <property type="protein sequence ID" value="OEV35242"/>
        <property type="gene ID" value="HS99_0033560"/>
    </dbReference>
    <dbReference type="OMA" id="RTLACNC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="31762" checksum="68E29EFC21FE3F7B" modified="2017-01-18" version="1">MPPRLSPTVRQQRLGIELRKMRERVGVTPKSLAATIGTDLPKISQMENGKSGISAERLRTWAHTCGCPEGPYLDALLAMTQDRRKYWWDGYRGRMPSGIVDIAEMEHHAASLSILNSTFIPGLLQTSDYAAAVFERLPAHYRQEAEVRKAFRIRRQQIFVDHPKPYSAILHESALRMQFGGPEVLREQLRSLLENSERPGVEIRVIPFSVPTYTGSGESLYLARGPVPELDTVQIDLSHGPKFVHSEAELASYRRIKEKTAAIALGTAESRDFIRALLKDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3X2</accession>
    <name>A0A1E7N3X2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278622.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000871.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2382"/>
    <dbReference type="EnsemblBacteria" id="OEV35386">
        <property type="protein sequence ID" value="OEV35386"/>
        <property type="gene ID" value="HS99_0032785"/>
    </dbReference>
    <dbReference type="OMA" id="KHGAWQQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="322" mass="34427" checksum="739A114445138F29" modified="2017-01-18" version="1">MTLPILRCAVLDDFQGVATSSADWSSLADRVEVTSFREHHGSEDELAAALAGFDIVVTLRERVPFPATLFARLPRLKLLIASGMRNSVIDHAAAAAHGVTVCGTASSGTPPVELTWALLLGLARGIVQENTALREGGPWQSTVGADLHGRTLGLLGFGRIGALVARVGLAFGMEVLVWSRSLTDERAAEAGVRRARSKEELLRESDFVSVHLASNAETHGLIGAAELALMKPDAYLVNTSRAAIVDQDALLAALTEGRIAGAALDVFDVEPLPADHPLRTAPRLLATPHLGYVSQDNYRRYFGEAVEDIEAFLEGEPIRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N491</accession>
    <name>A0A1E7N491_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0032960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282758.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5285"/>
    <dbReference type="EnsemblBacteria" id="ARF80700">
        <property type="protein sequence ID" value="ARF80700"/>
        <property type="gene ID" value="B6264_18900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35273">
        <property type="protein sequence ID" value="OEV35273"/>
        <property type="gene ID" value="HS99_0032960"/>
    </dbReference>
    <dbReference type="OMA" id="WAMMSIG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="591" mass="65093" checksum="C8BAF74BE6ECB6B9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N499</accession>
    <name>A0A1E7N499_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="1">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TenA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278198.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5496"/>
    <dbReference type="EnsemblBacteria" id="ARF79410">
        <property type="protein sequence ID" value="ARF79410"/>
        <property type="gene ID" value="B6264_11180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35521">
        <property type="protein sequence ID" value="OEV35521"/>
        <property type="gene ID" value="HS99_0031990"/>
    </dbReference>
    <dbReference type="OMA" id="FYIIQDY"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="24760" checksum="F00FF98001F124DB" modified="2017-01-18" version="1">MSTRTLTEELWASIEPIYAEILAHPFLGGLTDGTLPREAFRHFVVQDSHYLRDYARALAVCAAKAPGEEDVRAFADDAVGALAAEQGMHAEFLTAFGGSAEEAAAEPVLPTTRAYTSYLLATVYGGSFAEALGAVLPCYWIYARVGEALLAQGSPDPLYAKWIATYGDEAFQSVVRRVLALTDRLGEELSTAERRRVVEHFRTTSRYEWMFWDAAWRGERWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X7</accession>
    <name>A0A1E7N4X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281566.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80938">
        <property type="protein sequence ID" value="ARF80938"/>
        <property type="gene ID" value="B6264_20310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35735">
        <property type="protein sequence ID" value="OEV35735"/>
        <property type="gene ID" value="HS99_0007540"/>
    </dbReference>
    <dbReference type="OMA" id="DMVETDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23553" checksum="32ADDB790D3DE339" modified="2017-01-18" version="1">MPQPNVTELVRMWISGWVASRGAADPVGQPWGWTIDVGAPTGEVARHVLPEPTEAEVRKLAETTTAPTTWLKLFAEDDTVRPWLGPQWRLDQPGFLMTTPLTVEEPAPPAGYTLTTWARGGVLRALVRSEEGHLAARGQAGLAGAVAVPDQIVTAPDHRRRGLGSVVMRALQSGAYEAGARTGVLVGTAAGQGLYTALGWTTRAPMASLVLEAETPEGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N501</accession>
    <name>A0A1E7N501_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene797"/>
    <dbReference type="EnsemblBacteria" id="ARF80959">
        <property type="protein sequence ID" value="ARF80959"/>
        <property type="gene ID" value="B6264_20430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35752">
        <property type="protein sequence ID" value="OEV35752"/>
        <property type="gene ID" value="HS99_0007655"/>
    </dbReference>
    <dbReference type="OMA" id="WYRMLAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22581" checksum="C182CD734C1949A9" modified="2017-01-18" version="1">MSETDPRAAEQAPSARPHTGRRRNEAAHRAILDAALHLLADSDGTPVTIDAIARTAGVGKQTVYRWWPSKGAVLLDALTDRADRDVSDQPDTGSLRTDLRAFIETTFDAAQRSTTASALRTVVREAARDPHLAELMQTFTATRRTALHELLARGRERGELDGGADLDLIVDQVYGLFWYRFLLGHAPLDAAAAERLAATLTEGNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N594</accession>
    <name>A0A1E7N594_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286152.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7240"/>
    <dbReference type="EnsemblBacteria" id="ARF81075">
        <property type="protein sequence ID" value="ARF81075"/>
        <property type="gene ID" value="B6264_21130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35862">
        <property type="protein sequence ID" value="OEV35862"/>
        <property type="gene ID" value="HS99_0008350"/>
    </dbReference>
    <dbReference type="OMA" id="GWCQGRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017224">
        <property type="entry name" value="Opine_Oxase_asu/HCN_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037495">
        <property type="entry name" value="Opine_OX_OoxA/HcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="47572" checksum="C07DD2C056ABF26B" modified="2017-01-18" version="1">MPTSPSELFDLAVVGAGPAGLAAAVTAADLGLRCVLLDGADRTGGQYYRHPAPGLGAARPDRLHHGWAAYTGLAARLTAHRRAEFRGGHQVWALERTEDGFAVHVTLGPEAAERTTVRARTVLLATGAYERQLPFPGWTLPGVVTAGGAQAMLKAGLVLPGRRIVVAGSGPLLLAAASSLVGAGADVPAVVEASGYLGYARRPGVLAAVPAKLVEGAGHGSALLRHGVRLRPRSAVVEAHGDERVTGVTVARLGADWRPLPGTERRIDCDALAVGHGLLPQIELATELGAQTRTGPDGAVALRVDARLRTTVPGLWSAGETNGVGGADLALAEGELAAHAIAGEPPERALLRRRARLRAFAELMAAAHRPGPGWTGWLRPDTDVCRCEEVPVARIREAVEELGAGDPRTVKLLTRAGMGWCQGRMCGPAVACLSGATGAGPDRRPLACPVPLSQLAAGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L0</accession>
    <name>A0A1E7N5L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0007615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene805"/>
    <dbReference type="EnsemblBacteria" id="OEV35969">
        <property type="protein sequence ID" value="OEV35969"/>
        <property type="gene ID" value="HS99_0007615"/>
    </dbReference>
    <dbReference type="OMA" id="GRWPSAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198788" evidence="7">
        <location>
            <begin position="26"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="257"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="396"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="647"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="749" mass="76937" checksum="696C49D4D5C17EBA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U8</accession>
    <name>A0A1E7N5U8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HS99_0030885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553151.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4953"/>
    <dbReference type="EnsemblBacteria" id="ARF80021">
        <property type="protein sequence ID" value="ARF80021"/>
        <property type="gene ID" value="B6264_14865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36077">
        <property type="protein sequence ID" value="OEV36077"/>
        <property type="gene ID" value="HS99_0030885"/>
    </dbReference>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OEV36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="580" mass="64182" checksum="D4C372D22027E903" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y5</accession>
    <name>A0A1E7N5Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280974.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4972"/>
    <dbReference type="EnsemblBacteria" id="ARF80040">
        <property type="protein sequence ID" value="ARF80040"/>
        <property type="gene ID" value="B6264_14960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36095">
        <property type="protein sequence ID" value="OEV36095"/>
        <property type="gene ID" value="HS99_0030980"/>
    </dbReference>
    <dbReference type="OMA" id="GPQFLIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6801" checksum="59E7D37D9AAA8AD7" modified="2017-01-18" version="1">MTARLARPRHNRVIAGVCAGIAERFGLAPFTVRLIFLLSCLLPGPQFLIYLALWVLLPQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H4</accession>
    <name>A0A1E7N6H4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737892.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2629"/>
    <dbReference type="EnsemblBacteria" id="OEV36290">
        <property type="protein sequence ID" value="OEV36290"/>
        <property type="gene ID" value="HS99_0030245"/>
    </dbReference>
    <dbReference type="OMA" id="IVHWKEV"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="518"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="629" mass="65763" checksum="E6AD1880DDB978B2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N731</accession>
    <name>A0A1E7N731_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386925.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1483"/>
    <dbReference type="EnsemblBacteria" id="ARF79198">
        <property type="protein sequence ID" value="ARF79198"/>
        <property type="gene ID" value="B6264_09940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36500">
        <property type="protein sequence ID" value="OEV36500"/>
        <property type="gene ID" value="HS99_0028640"/>
    </dbReference>
    <dbReference type="OMA" id="VPADKWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="30589" checksum="8CAD640585AFF2A6" modified="2017-01-18" version="1">MTDQQRTGRPARRPRPHLRSAAGAALLAAALAAGAAGCSGRSGGGSSDQQSAAADHLAADPVTAVRNAADITGRTGSAHAATELVTESADKKASFSGSGGYDYVKRIGRLEVQVPPGAATTGKIVEVVLPGTVYLQNSGAKVPEGKWVKLDVRQLPDGNLVSSGATDPASAAGALRGVQKADLVGTETVDGVPLHHYRGTLDLAKAADATGGRGGDGLRTGGQTFTVKEVPYDAWLDDHGRLHKVVEVFTFAGVAGSKEAKDQVKVTSTTSLSDFGKPVEAAEPPASDIYQMKPSESPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D1</accession>
    <name>A0A1E7N7D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000302.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1445"/>
    <dbReference type="EnsemblBacteria" id="OEV36600">
        <property type="protein sequence ID" value="OEV36600"/>
        <property type="gene ID" value="HS99_0028825"/>
    </dbReference>
    <dbReference type="OMA" id="MFVYLPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="41557" checksum="E6D47FB9217AC3B6" modified="2017-01-18" version="1">MELTSEALVNSLLALGVVALVSTLWVWPRLASQRPLPVLGRIGLLTVVQVSILAVLALSVNNSFGFYTSWDDLLNPGGAKRVLTSNENHKGGTPVSDQLVQPTDEGGLEGVGNLPKGAPEEVGKIESVRVNGKETGFSDQMFVYLPPEYFDPKFALVRFPVVLALAGFPGTTLNLLKELPLLQTAVELQHSGKMPPTVLVLARPAVVPARDTECVDVPGGPRTETWFVKDVPAALHSAYRLGRSAGSWGLFGYSTGGSCAMRLSMRFPNVYGNAAGLHGDFAVRQDQYTGGDLFNGDKTLTQQHDLDWRLQNLPAPPLNLLVVSTRKEADYPQTVQFVEQAAQVSAANPQFKVESLYLDDGGHNFDSWTRELPASLEWLGSHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M1</accession>
    <name>A0A1E7N7M1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386296.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2461"/>
    <dbReference type="EnsemblBacteria" id="ARF81532">
        <property type="protein sequence ID" value="ARF81532"/>
        <property type="gene ID" value="B6264_23805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36702">
        <property type="protein sequence ID" value="OEV36702"/>
        <property type="gene ID" value="HS99_0028520"/>
    </dbReference>
    <dbReference type="OMA" id="IMLDDHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="25123" checksum="49F9AFDCB71BCD32" modified="2017-01-18" version="1">MATMAEGAEASAPVRVFLLDDHEVVRRGVYDLLDGEPDLVVVGEAATAEQALVRVPALRPDVAVLDVRLGDGDGVSVCRELRSRMPDLACLMLTSFDDEEALLDAVMAGAAGYVLKQISGTDLVAAVRTVASGRSMLDPGAATRLLNRLRSDAEPARPVTAGPALTAREQEVLALIGEGLTNRQIGERLYLAEKTVKNHVSRLLAKLGVERRVQAALIATELRQSAAARPSPLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P3</accession>
    <name>A0A1E7N7P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0028405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550690.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2484"/>
    <dbReference type="EnsemblBacteria" id="ARF81516">
        <property type="protein sequence ID" value="ARF81516"/>
        <property type="gene ID" value="B6264_23690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36688">
        <property type="protein sequence ID" value="OEV36688"/>
        <property type="gene ID" value="HS99_0028405"/>
    </dbReference>
    <dbReference type="OMA" id="MMQKAAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="41261" checksum="D5EB6CC82A362C74" modified="2017-01-18" version="1">MSGIGSQLLETPERTALRKAVGDLGRRYGSAYYLAKARAGEPADELWAEAGKAGYLGVNLPAEYGGGGGGISDLAIVLEELGTAGCPLLLLIVSPAICGTVIARYGTEEQKQRWLPGLADGSRRMAFGITEPDAGSNSHRISTVARRDGEDWLLTGRKVFVSGIDHSDAVLFVARTEDARTGKLKPCLFVVPRDTPGFEYRAIPMELVAPEKQFQVFLDDVRLPADALVGDENAGLLQLFAGLNPERVLTAAFSLGLARQALGKAVEYAKTRTVWSTPIGAHQGLAHPLAQCAVEIELARLMTQKAGLLYDAGEDVAAGEAANMAKYAAGEAAARTVDQAVQTLGGNGLTQEYGLGALLAATRVGRVAPVSREMVLNYVAQHTLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7S6</accession>
    <name>A0A1E7N7S6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278794.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81524">
        <property type="protein sequence ID" value="ARF81524"/>
        <property type="gene ID" value="B6264_23750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36694">
        <property type="protein sequence ID" value="OEV36694"/>
        <property type="gene ID" value="HS99_0028465"/>
    </dbReference>
    <dbReference type="OMA" id="FHALACD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="19541" checksum="45D54EC7C6C07250" modified="2017-01-18" version="1">MLGFLKTDDETLVSCLGDPQRTVAAYHELLRRGPGALGAIRAGLSHDHSAVREGCCRLLDHLVDTDSMDLLVAMADDPDAEVRVAAFHALACDRCKDDACAPGAGLVLEPALRHLADDPDPRVRARAAELVGKFAHSDARAVAALQACQAGDPSPAVRKKAGWYAPGGPIHRRTAPRAGRSLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T2</accession>
    <name>A0A1E7N7T2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">HS99_0028785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030059594.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000953.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1453"/>
    <dbReference type="EnsemblBacteria" id="ARF79174">
        <property type="protein sequence ID" value="ARF79174"/>
        <property type="gene ID" value="B6264_09795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36523">
        <property type="protein sequence ID" value="OEV36523"/>
        <property type="gene ID" value="HS99_0028785"/>
    </dbReference>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="18434" checksum="D7C632E60A38EC6A" modified="2017-01-18" version="1">MEFDVLIEIPKGSRNKYEVDHETGRLRLDRMLFTSTRYPADYGYVEGTLGEDGDPLDALVILDEPTFPGCLIKCRAIGMFHMTDEAGGDDKLLCVPATDPRWEHLRDIHHVSEFDRLEIQHFFEVYKDLEPGKSVEGANWVGRAEAEAEVTASIKRLAEQGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U1</accession>
    <name>A0A1E7N7U1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4780"/>
    <dbReference type="EnsemblBacteria" id="OEV36755">
        <property type="protein sequence ID" value="OEV36755"/>
        <property type="gene ID" value="HS99_0027460"/>
    </dbReference>
    <dbReference type="OMA" id="WIRFRAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="22163" checksum="380FADD256B00E0E" modified="2017-01-18" version="1">MKDMNTTRTARTPATPALNGCGTSRRRPRARIGLAATATALSLLPIAPSTASAAPHLPLTQIVREAKVKAQQEHPGSQFYDADAVLLTPTTNPNDVQAWWIRFRAKDSEPSFEYKYSTTGQYQSTQPWSVPIGIQAISPFTMTEVQAHDLAVKAGHTGAFKPLYLNEPVVQNPHPTYYFCIPSEGRTVAVDTVTGHVTTPWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U3</accession>
    <name>A0A1E7N7U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284627.1">
        <property type="nucleotide sequence ID" value="NZ_JNWR01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4814"/>
    <dbReference type="EnsemblBacteria" id="OEV36777">
        <property type="protein sequence ID" value="OEV36777"/>
        <property type="gene ID" value="HS99_0027615"/>
    </dbReference>
    <dbReference type="OMA" id="DDPMMQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24726" checksum="33853D2028F92235" modified="2017-01-18" version="1">MADNTAAGAGDPVKVFLLDDHEVVRRGVHDLLDSEPGFTVVGEASTVAQALTRVPALRPDVAVLDMRLPDGDGVTVCRELRSRMPELACLILTSFDDEEALLDSIMAGAAGYVLKQISGTDLVSAVRTVASGQSMLDPGAATRLMARLRGEAAQQPSDGPHLTDREREILALVGEGLTNRQIGQRLYLAEKTVKNHISRLLAKLGVERRVQAAIIATQVLSGRNQTGARTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N898</accession>
    <name>A0A1E7N898_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6456"/>
    <dbReference type="EnsemblBacteria" id="ARF78680">
        <property type="protein sequence ID" value="ARF78680"/>
        <property type="gene ID" value="B6264_06910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36874">
        <property type="protein sequence ID" value="OEV36874"/>
        <property type="gene ID" value="HS99_0026775"/>
    </dbReference>
    <dbReference type="OMA" id="LPYAWEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="14530" checksum="71A5D3356D26B6E8" modified="2017-01-18" version="1">MSLDVSPALLEKAERGEVDEREFVDCVRVSLPYAWDLISSLVAQAKVDGTDFADNQVPPPSEQARGQLLRALASDAIRGALQRHFGVRLAFQNCHRVAVFLPSEANAARYDRFTSVREQLLNQSEELRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H6</accession>
    <name>A0A1E7N8H6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557250.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81750">
        <property type="protein sequence ID" value="ARF81750"/>
        <property type="gene ID" value="B6264_25175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36979">
        <property type="protein sequence ID" value="OEV36979"/>
        <property type="gene ID" value="HS99_0003840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18796" checksum="C37A4CBE81EFF6F7" modified="2017-01-18" version="1">MLRLGVRRQGKWGEVKGIDLRRATGALAIALLGGGWLLSGCAGDPEPAPDPLSHPCLLLSASQATDVLHRSPGPAKEITQEEVSECAYQEAELYVSVAHASYDRQSFRDVVDRTKGQPATEAGLADAAYSFHVQEESRDFVLLDILKGSRLVQITAPTAEDARQTALLVLPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H9</accession>
    <name>A0A1E7N8H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557876.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5986"/>
    <dbReference type="EnsemblBacteria" id="ARF81728">
        <property type="protein sequence ID" value="ARF81728"/>
        <property type="gene ID" value="B6264_25045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36997">
        <property type="protein sequence ID" value="OEV36997"/>
        <property type="gene ID" value="HS99_0003970"/>
    </dbReference>
    <dbReference type="OMA" id="TDGHARI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="29174" checksum="C1EEC7D6A5F33FBE" modified="2017-01-18" version="1">MEAADLTRVRYEKRGRVAHVTLDRPDRANAMDLRMHEELAFVWDDFESDDELWLAVLTGAGQRAFSAGQDLKELAASIEEGSNAPSTFGSRGKPGWPRLTERFDLAKPVVARVNGAAFGGGFELALACDVIVAADTATFALTEAKLGLTAGAGGVFRLTRQAPYRVALGHLISGRPMTADRAYELGLVNEVVPAADLDSAVDAWVADILGCAPLAVRAVKQAAAAAATMPLQQAFQTRFPWEERRMHSEDADEGPRAFVEKRPPRWQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K4</accession>
    <name>A0A1E7N8K4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0004130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7479"/>
    <dbReference type="EnsemblBacteria" id="OEV37026">
        <property type="protein sequence ID" value="OEV37026"/>
        <property type="gene ID" value="HS99_0004130"/>
    </dbReference>
    <dbReference type="OMA" id="IALVIPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="262"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="717"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="818" mass="84438" checksum="76EDEECB6CC93FC4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N3</accession>
    <name>A0A1E7N8N3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7443"/>
    <dbReference type="EnsemblBacteria" id="OEV37060">
        <property type="protein sequence ID" value="OEV37060"/>
        <property type="gene ID" value="HS99_0004330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="92"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="603" mass="66628" checksum="F1BE2E110E69C4D7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q3</accession>
    <name>A0A1E7N8Q3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556083.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7414"/>
    <dbReference type="EnsemblBacteria" id="ARF81648">
        <property type="protein sequence ID" value="ARF81648"/>
        <property type="gene ID" value="B6264_24525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37080">
        <property type="protein sequence ID" value="OEV37080"/>
        <property type="gene ID" value="HS99_0004465"/>
    </dbReference>
    <dbReference type="OMA" id="RAWNDRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35542" checksum="DCC6898E35D78D4B" modified="2017-01-18" version="1">MEQRVLGRTGRPVSIVGLGTWQLGADWGDVREEDALAVLEASVEAGVTLFDTADVYGDGRSERLIGRFLKERPDAEVFVATKFGRRVEQRPQHYHLANFRAWADRSRENLGVERLDLVQLHCPPTPVYSSDEVFDALDTLVAEERIAAYGVSVESCAEALTAIARPGVASVQIILNAFRLKPLERVLPAAEAAGVAILARVPLASGLLSGRYSERTVFAPDDHRTYNRHGEAFDQGETFSGVDFATGVEAAREFAALAPEGATAAQTALRWVVQQPGVTTVIPGARNVAQARANAAAAALAPLPPATLDAVRELYDRRIRPQVHDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R5</accession>
    <name>A0A1E7N8R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556067.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7407"/>
    <dbReference type="EnsemblBacteria" id="ARF81641">
        <property type="protein sequence ID" value="ARF81641"/>
        <property type="gene ID" value="B6264_24490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37087">
        <property type="protein sequence ID" value="OEV37087"/>
        <property type="gene ID" value="HS99_0004500"/>
    </dbReference>
    <dbReference type="OMA" id="PPHWHEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17702" checksum="5ED4DA7320AE066A" modified="2017-01-18" version="1">MTEDTKNSEAQNRPALSVVGPGEGETIVLGTTRMRVLEDGSHTGHRLAIAESVLAPHTQGPPQHRHARHDEGFYILSGTVRFTVGDQDHEAAAGTLVMVPPGTPHTFANLTDEPAVMLSTFTPDLYVQYFRDLQDALDGGRPLTPQANIDAMSRYATEPATDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z9</accession>
    <name>A0A1E7N8Z9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0004915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37162">
        <property type="protein sequence ID" value="OEV37162"/>
        <property type="gene ID" value="HS99_0004915"/>
    </dbReference>
    <dbReference type="OMA" id="MIMAHEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198890" evidence="5">
        <location>
            <begin position="42"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="41984" checksum="3FF69FF4B100D349" modified="2017-01-18" version="1">MNTTSNRKRRISAVAILSLAASVAATGTGLAATTPPSTVHATAVTAAAAPPRSFQGTLPAPTGPYAAGEDVIHLTDESRPDPWVPSSGPRQLTITMVYPAVPGTGTPAPYMTLGEAAGILQHRKMPASSGITPQNLAGVTTHAFDGARPQRGKHPLVVLSAAAENPRMMLTSLATELASHGYVVALVGHTYEDTGETLADGQTPPCAICDHPETLDFDSVAASRARDVSFVIDQLTHGNGAWRLAHLIDKHEIGMAGHSLGGAATAATMVADPRVGAGVDMDGTFFPVPTPGQINRPFLMLGRADGHTPGGGGDDVVWKQAWDALGGYKKWLTVAGADHFSFADQDVLQEQAGVPSASPLSPERGVEITREYVTAFFDQTLKGSDSPLLDGPSPNNPEVLFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G8</accession>
    <name>A0A1E7N9G8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555075.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1247"/>
    <dbReference type="EnsemblBacteria" id="OEV37308">
        <property type="protein sequence ID" value="OEV37308"/>
        <property type="gene ID" value="HS99_0005835"/>
    </dbReference>
    <dbReference type="OMA" id="RYAEYGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20452" checksum="3DDBD4ECD5B61817" modified="2017-01-18" version="1">MSTAHASPGDYSQVPNPEQALKYAIQHIAGDRVEIVEGVITPVSPSWAHETAVDLIREQIGPRMRELGLRAGSGNLDLPGTENFYVPDLAVVPAELAKTEGALLPDQTVLVVEVTSPSNGDTDRTSKRRRYSQFGAPVYLLVDRQERTCTLFSQPGQLGYTRVEGPHPFGTPLQLPSPFNLELDTAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K6</accession>
    <name>A0A1E7N9K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556406.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82485">
        <property type="protein sequence ID" value="ARF82485"/>
        <property type="gene ID" value="B6264_29690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37372">
        <property type="protein sequence ID" value="OEV37372"/>
        <property type="gene ID" value="HS99_0006220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14521" checksum="44520CE382236484" modified="2017-01-18" version="1">MLDHIVTGRLDDVAPEPADEDVLDQLTRTTDNAHVYLEAWLTAAYLDGTGCYADPAVRAASQLPELLLGHANRRHSCPPGCPGTSAQCDGCAQACGGDAHRRQALMSRLFAHILADRQQEARRLLVVPVAGPDAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M8</accession>
    <name>A0A1E7N9M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481686.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000093_gene112"/>
    <dbReference type="EnsemblBacteria" id="ARF82511">
        <property type="protein sequence ID" value="ARF82511"/>
        <property type="gene ID" value="B6264_29845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37397">
        <property type="protein sequence ID" value="OEV37397"/>
        <property type="gene ID" value="HS99_0006365"/>
    </dbReference>
    <dbReference type="OMA" id="DWGHPVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="39065" checksum="4A020AFEB7280C0E" modified="2017-01-18" version="1">MPLPFTPVTESELEDLHRRLAATRRPPLASGAGWERGMDADFLAHLLDSWRERYDWRTHEARILSLPWARAGRGDRTLHLVHQRAGADAPAVVLLHGWPDSALRFERLLPLLTDLNVVVPALPGYPFSNGPAQPGTTTATMASLVADAVDALGYHRYVVSGGDVGADVAEQLAAMHPDRVTALHLTNISPLHAVFADRSSLGAEELAYLDTAAAWQRAEGGYIAEQSTKPHTLAPALADSPAGLAAWIVEKLHSWSHTPFEEDDLLTWTSAYWFTNTIGTSFAPYSELAPPVPYMATPTVVSAFAHDTKPAPRSFVSRFVNVHEFVEHQDGGHFAAWEQPLRYVQDLRRAVALANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q4</accession>
    <name>A0A1E7N9Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556402.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82487">
        <property type="protein sequence ID" value="ARF82487"/>
        <property type="gene ID" value="B6264_29700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37374">
        <property type="protein sequence ID" value="OEV37374"/>
        <property type="gene ID" value="HS99_0006230"/>
    </dbReference>
    <dbReference type="OMA" id="WRDEDWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="15228" checksum="B18B481A744FB016" modified="2017-01-18" version="1">MGGSGWAETGPYQEDLGAAFRQAQARELAKDDHGFPGQSISELWRDEDWQEYILTGGTGTVLDFYALIDAEGGDDVAMMRPLTGSEVRSWAPNGRPTREQWEAALPQLLNPVGRGMGRCTVLYQDGEPAEIAYWGCTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA27</accession>
    <name>A0A1E7NA27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552685.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7964"/>
    <dbReference type="EnsemblBacteria" id="ARF79080">
        <property type="protein sequence ID" value="ARF79080"/>
        <property type="gene ID" value="B6264_09250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37494">
        <property type="protein sequence ID" value="OEV37494"/>
        <property type="gene ID" value="HS99_0026105"/>
    </dbReference>
    <dbReference type="OMA" id="INIRTVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33763" checksum="A4DF9D12826113E8" modified="2017-01-18" version="1">MRASRLVNLLLLLQNRGRMTARQLAEELEVSARTVYRDVEALAAAGIPLYGEAGHAGGYRLVDGYRTRLTGLTADEAQAAFLAALPGTAAELGLGEALATAQLKLRAALPAELREHAGRIQERFLLDAPGWYGDADETPHLAAVAAAVWGRRAVVLRYRRWRAPEEIERRVEPYGLVLKAGRWYLVAGGPSGTRTYRVDQIIELGEQREEFAVPGGFGLAAYWQGYLADFRARLHTGEALVRLTPEGARRLGVAPAEGGWTRARVPIESVDHAHGEFLRLGAEVEVLEPAELRDRIAGTVRALAARYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA54</accession>
    <name>A0A1E7NA54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556403.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82486">
        <property type="protein sequence ID" value="ARF82486"/>
        <property type="gene ID" value="B6264_29695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37373">
        <property type="protein sequence ID" value="OEV37373"/>
        <property type="gene ID" value="HS99_0006225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13431" checksum="955EE0161E38A1D9" modified="2017-01-18" version="1">MSSPAAVEFAVRFLEADEINALLLRAGSLPGADLRMLMYYATAVPIGEAVTKTTTDIGRELGLSTTSASRSIGRLAAAGWLELSHSAVGSRFYVLGRAALGIETDEKDEVAGEDGQLAKVHQLRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA80</accession>
    <name>A0A1E7NA80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286498.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1137"/>
    <dbReference type="EnsemblBacteria" id="ARF79017">
        <property type="protein sequence ID" value="ARF79017"/>
        <property type="gene ID" value="B6264_08885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37554">
        <property type="protein sequence ID" value="OEV37554"/>
        <property type="gene ID" value="HS99_0026470"/>
    </dbReference>
    <dbReference type="OMA" id="QPYLFPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30246" checksum="77B9138929C751B2" modified="2017-01-18" version="1">MSQAETVLVAGRRPQTTSGFLALFRNELHLTFRRMRTKVLLAILAALPILIGVIVKLNTDSPRGGGGGAPSFIAQTTQNGLFLVFTALAVALPVFLPMTVGVVAGDSVAGEAATGTLRYLLVAPAGRTRLLAAKFTAGLVFCLAATAAVAVTALATGATLFPLGEVTLISGDTIGFTDALLRAVLVAGVVAVSLAGLVAIGLFVSTLTGSGIAAMAATVGLVITVQILDAFPQLDAVRPFLFTHYWMSFSDLLREPMYWDGVWKDLGLQAAYVAVFGSAAWARFSSRDISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ0</accession>
    <name>A0A1E7NAJ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287159.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7974"/>
    <dbReference type="EnsemblBacteria" id="ARF79070">
        <property type="protein sequence ID" value="ARF79070"/>
        <property type="gene ID" value="B6264_09200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37503">
        <property type="protein sequence ID" value="OEV37503"/>
        <property type="gene ID" value="HS99_0026155"/>
    </dbReference>
    <dbReference type="OMA" id="VCELWRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="458" mass="49872" checksum="008E14308B6EC6ED" modified="2017-01-18" version="1">MAARPLVARQPNERLQQLIQEASCSNAGLARRVNLCGAEHGLDLRYDKTSVARWLRGQQPRGQAPAVIAEALGRKLGRSVSVEEIGMADGKNLSSGIGLQFAPTLGAALEQVCELWRSDVGRRDFLTGATVAASALVEPSRDWLITPPDPVVARGGGPRVGPTDVAAIRATTTMLVDLDHRFGSGHVRPVVVHYLNSVVSGLLGGAYREETGRQLFAAVARLTELAGYMAVDTGQPGLAQRYYIQALRLAQAADDRGYGGYVLAASMSHLAATLGNPREIAQLARAAQEGARSVATPTAMAMFYAAEARGHALLGDARSCEAVSAKALEMMEKRRPEDDPDWIAHFDDAYLADELAHCHRDLEQAGPAEHYARRALDLHPPTRVRRRAVDLVLLATAQLQQRDLERACETGTQAVRLLSGLRSNRGVEYLDEFRRRLEPYREQRVVREFHARADAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ2</accession>
    <name>A0A1E7NAJ2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="6" type="ORF">HS99_0025645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030055835.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1665"/>
    <dbReference type="EnsemblBacteria" id="ARF79945">
        <property type="protein sequence ID" value="ARF79945"/>
        <property type="gene ID" value="B6264_14435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37688">
        <property type="protein sequence ID" value="OEV37688"/>
        <property type="gene ID" value="HS99_0025645"/>
    </dbReference>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6981" checksum="F277307B753619FF" modified="2017-01-18" version="1">MARLKITQTKSYIGSKQNHRDTLRSLGLKRMHDVVVKEDRPEIRGMAHTVRHLVTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ7</accession>
    <name>A0A1E7NAJ7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">HS99_0025810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280849.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1632"/>
    <dbReference type="EnsemblBacteria" id="ARF79974">
        <property type="protein sequence ID" value="ARF79974"/>
        <property type="gene ID" value="B6264_14600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37717">
        <property type="protein sequence ID" value="OEV37717"/>
        <property type="gene ID" value="HS99_0025810"/>
    </dbReference>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV37717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="542" mass="56688" checksum="661FD58FF76AE9B6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY6</accession>
    <name>A0A1E7NAY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3448"/>
    <dbReference type="EnsemblBacteria" id="OEV37860">
        <property type="protein sequence ID" value="OEV37860"/>
        <property type="gene ID" value="HS99_0024510"/>
    </dbReference>
    <dbReference type="OMA" id="QGLDWHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198950" evidence="3">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="22501" checksum="6041D249FB1EC687" modified="2017-01-18" version="1">MAVVAGAAVAALPVAGLVTATSASAAPVSTWDAVAQCESGGNWAINTGNGFFGGLQFTSSTWAAYGGTAYAAQANQATKAQQISVAEKVLASQGPGAWPVCSVKAGLSKGGAPAAVDTTAGSSAAKPAQAPAPKAATPKAAAAPKAAAAPKADAPKAAAPKADAAPKADAAKSWTGSNDAKPAKGSYTVKSGDTLSSIAAAQGLDWHDLYKNNAKVIGGNPDLIFPGQTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB50</accession>
    <name>A0A1E7NB50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0023700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2137"/>
    <dbReference type="EnsemblBacteria" id="OEV37888">
        <property type="protein sequence ID" value="OEV37888"/>
        <property type="gene ID" value="HS99_0023700"/>
    </dbReference>
    <dbReference type="OMA" id="FAIMHIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="38599" checksum="EF755FE81816593D" modified="2017-01-18" version="1">MTAVRPEGRYQSGADPYGGAQQYGGAQPYDAPSYGVGSPHPQEHPVQSASEDGWGVYEQAEQPVEGGPEYPWLPDQTLQLRLPADGAEPVTEPAPPTGGRAERRRAAQGRTSVRAGGGRRRAKGRGAGGPRPKESAAVVAARFVGELCITLGVVMLLFVAYQLWWTNVQADEAASGARNQLEQQWDAQPPGAGQPAPDPNKPEVFEPGKGFAIIYLPKLGLKFPIAEGTSKSAVLDKGLVGHYTGTAMPGDQSGNFALAAHRNTHGEPFRYINELGKGDKVVVETAFGYYTYELTGGIPQTSPNNVSVIKPVPNGSGYTGPGRYITLTTCTPEFTSKFRLILFGKLVEERPRSQGKPAAITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB58</accession>
    <name>A0A1E7NB58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552135.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2142"/>
    <dbReference type="EnsemblBacteria" id="ARF79433">
        <property type="protein sequence ID" value="ARF79433"/>
        <property type="gene ID" value="B6264_11340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37884">
        <property type="protein sequence ID" value="OEV37884"/>
        <property type="gene ID" value="HS99_0023675"/>
    </dbReference>
    <dbReference type="OMA" id="ITQDHTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="550" mass="57799" checksum="D05B5B83BC12F63F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS5</accession>
    <name>A0A1E7NBS5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598964.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7144"/>
    <dbReference type="EnsemblBacteria" id="ARF79653">
        <property type="protein sequence ID" value="ARF79653"/>
        <property type="gene ID" value="B6264_12710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38137">
        <property type="protein sequence ID" value="OEV38137"/>
        <property type="gene ID" value="HS99_0023380"/>
    </dbReference>
    <dbReference type="OMA" id="LDLAMYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="562" mass="57955" checksum="2B04F9D48641CFAF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC25</accession>
    <name>A0A1E7NC25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat-shock protein HspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2024"/>
    <dbReference type="EnsemblBacteria" id="OEV38023">
        <property type="protein sequence ID" value="OEV38023"/>
        <property type="gene ID" value="HS99_0024275"/>
    </dbReference>
    <dbReference type="OMA" id="GRRYSEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="17270" checksum="75795BC196C07716" modified="2017-01-18" version="1">MPGNAPRRPRRAAAPPQYVLTEETPVYVISVAAELSGLHPQTLRQYDRLGLVSPDRTAGRGRRYSARDIQQLREVQRLSQDEGINLAGIKRIIELENQVAALQARITELADSLDSAAAALQQREAAVHASYRRDLVPYQPPTPQSSALVVWRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC63</accession>
    <name>A0A1E7NC63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284095.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4201"/>
    <dbReference type="EnsemblBacteria" id="ARF80203">
        <property type="protein sequence ID" value="ARF80203"/>
        <property type="gene ID" value="B6264_15925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38280">
        <property type="protein sequence ID" value="OEV38280"/>
        <property type="gene ID" value="HS99_0022345"/>
    </dbReference>
    <dbReference type="OMA" id="DIEACIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="7879" checksum="EE21F521EB41C3CE" modified="2017-01-18" version="1">MASKAEKIVAGLGGIDNIEEVEGCITRLRTEVKDAALVDEAALKAAGAHGVVKMGTAIQVVIGTDADPIAADIEDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI7</accession>
    <name>A0A1E7NCI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366400.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82193">
        <property type="protein sequence ID" value="ARF82193"/>
        <property type="gene ID" value="B6264_27920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38416">
        <property type="protein sequence ID" value="OEV38416"/>
        <property type="gene ID" value="HS99_0021135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="10934" checksum="69E65973BA6F9FAF" modified="2017-01-18" version="1">MARVVWHVPVTTNATGSTTALRLFRTRDGRRCAVGFSSPEALAALLGPEQAYTELGEPALRTLTSPLGVDTLVLDPRLVAPPVPTPAAAPAAAPAPTSATQLQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND52</accession>
    <name>A0A1E7ND52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene279"/>
    <dbReference type="EnsemblBacteria" id="ARF82197">
        <property type="protein sequence ID" value="ARF82197"/>
        <property type="gene ID" value="B6264_27940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38413">
        <property type="protein sequence ID" value="OEV38413"/>
        <property type="gene ID" value="HS99_0021115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23021" checksum="C4F10B8FB1FF9A5B" modified="2017-01-18" version="1">MAVMAAAARAGTDRIVHLSTTAVYGEGPHTGVGVDEVLAAPLSEASRTRLLGEGHALAAGAVVLRPALVTGTGDRWVVPGLAELARRVPGRWAGGDVRISLVDRTDLARLITALALDAPAPVAGVHHAAHPEPVRSGDLLDALAGLGLLPALDGPALSWEECRRLLAARPGTVSERQLAMIARDHWYRSDDVWRLAACPPGPGPLARLAGAAPWYRAALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND84</accession>
    <name>A0A1E7ND84_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737794.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000704.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1780"/>
    <dbReference type="EnsemblBacteria" id="ARF77693">
        <property type="protein sequence ID" value="ARF77693"/>
        <property type="gene ID" value="B6264_01050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38660">
        <property type="protein sequence ID" value="OEV38660"/>
        <property type="gene ID" value="HS99_0020635"/>
    </dbReference>
    <dbReference type="OMA" id="GYANRHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="34719" checksum="38CAB5D8392CF550" modified="2017-01-18" version="1">MPPTAPTAPTVKATPAFPYTERDLARFRETQQLAYHCAEQVAAWIEPGVTERQATAELRRRLITAGVQDFFHVPFAWFGDRTAFRHFHTPLQFFAGNRRLEEGMPYVLDCAPVVDGYTADIGYGGKIGENRVWDRLAADLQVYRELILAEVRARRPLNEVYAAVDAQIAAHGYDNRHQVYPGRVIGHQVTRTTVRGPAGVNVLGFGVRTLQTLGRELISERLHGRSPLWADGRSSRHAPTPGLWAVEPHIGFRGVGIKFEELLVVTEDDAHWLDDDLPHVRRWSAGTAAATEPTERTEPTDEPTTLEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL1</accession>
    <name>A0A1E7NDL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene590"/>
    <dbReference type="EnsemblBacteria" id="OEV38718">
        <property type="protein sequence ID" value="OEV38718"/>
        <property type="gene ID" value="HS99_0020440"/>
    </dbReference>
    <dbReference type="OMA" id="AHQKVEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15664" checksum="ECB505DE752E7EBC" modified="2017-01-18" version="1">MRRPDRPDRSDRSDRGGIAIEAAIVVPGVIGLVLLAIAAGRVQTAAGTVEAAARAGARTGSLQRSVAGVDKPARDSALATLHQQGVTCRHEDVRVTTDELTLDDGPVVTVKVTVDCDVELADLLGGPSGLPVTKHLSAEFISVMDRYRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDY1</accession>
    <name>A0A1E7NDY1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290502.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6538"/>
    <dbReference type="EnsemblBacteria" id="ARF81307">
        <property type="protein sequence ID" value="ARF81307"/>
        <property type="gene ID" value="B6264_22525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38899">
        <property type="protein sequence ID" value="OEV38899"/>
        <property type="gene ID" value="HS99_0019790"/>
    </dbReference>
    <dbReference type="OMA" id="EMWWCLS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="7434" checksum="0466C830EFB5166A" modified="2017-01-18" version="1">MSGRLTWARIEMWWCLSAQFSRPVRALSPRRRSAHTEMQFWAATPGNAEALLRAVLRQAARHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG1</accession>
    <name>A0A1E7NEG1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557537.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83259">
        <property type="protein sequence ID" value="ARF83259"/>
        <property type="gene ID" value="B6264_30435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39028">
        <property type="protein sequence ID" value="OEV39028"/>
        <property type="gene ID" value="HS99_0018165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9255" checksum="C5BD84B6BC0D9429" modified="2017-01-18" version="1">MVLLDVESVRPDVTGLIDLTLPAVLRQAGHDTSPDRVLGLYLDAASARRRLDGPLVEVRPVRVRGGNRVEKPSRPGPVNAEGPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER1</accession>
    <name>A0A1E7NER1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase</fullName>
            <ecNumber evidence="5">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0000180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285147.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3497"/>
    <dbReference type="EnsemblBacteria" id="OEV39187">
        <property type="protein sequence ID" value="OEV39187"/>
        <property type="gene ID" value="HS99_0000180"/>
    </dbReference>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="8">
        <location>
            <begin position="287"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="54570" checksum="B3DF5156BF25C8A3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW8</accession>
    <name>A0A1E7NEW8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550178.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000840.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3560"/>
    <dbReference type="EnsemblBacteria" id="OEV39237">
        <property type="protein sequence ID" value="OEV39237"/>
        <property type="gene ID" value="HS99_0000485"/>
    </dbReference>
    <dbReference type="OMA" id="VHARGMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="28"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26652" checksum="EB6F7B670F7FF5A6" modified="2017-01-18" version="1">MTRHQAADSTPTTTGATATSATATGPMVAVTDLRRSFGTGERTVHALRGISFSVGRGELTALKGRSGSGKTTLLNLVGGLDAPTGGSIALDGIDLGGLDEDGRLALRRERIGFVFQSFGLIPMLTAAENVGVPMRLRKVLPAEREERAHTLLALVGLADHANQRPGELSGGQQQRVAIARALANGPGLIIADEPTGQLDSETGRSIMELLRAVVRSEGVTVLVATHDPTLMELADRVIELHDGRIVEEDVEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW9</accession>
    <name>A0A1E7NEW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3589"/>
    <dbReference type="EnsemblBacteria" id="OEV39256">
        <property type="protein sequence ID" value="OEV39256"/>
        <property type="gene ID" value="HS99_0000620"/>
    </dbReference>
    <dbReference type="OMA" id="YRVNNCV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199071" evidence="3">
        <location>
            <begin position="33"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="5">
        <location>
            <begin position="257"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="519" mass="53292" checksum="54D269EFD26A8D97" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEY7</accession>
    <name>A0A1E7NEY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829890.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3523"/>
    <dbReference type="EnsemblBacteria" id="OEV39208">
        <property type="protein sequence ID" value="OEV39208"/>
        <property type="gene ID" value="HS99_0000300"/>
    </dbReference>
    <dbReference type="OMA" id="PWLTTAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="12249" checksum="B3F502A9AAA01E2A" modified="2017-01-18" version="1">MNSRVGVARIEGYLAWEAEVAAAERAARAFAAQFPWLPDAERENLELAYTADRLRYAEEVVDRAVQRCRRLAARYRAECRRICTRWAALCLSATIVAALLAVLPAALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF18</accession>
    <name>A0A1E7NF18_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737757.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39301">
        <property type="protein sequence ID" value="OEV39301"/>
        <property type="gene ID" value="HS99_0000885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="29834" checksum="06263A1C2658C73A" modified="2017-01-18" version="1">MRRLGPGRAPADLERVVAAVRAVTGLPYELLGHSAGAALALATAAARNSDRALRRVLVLDTTGPYDPGTEPELVARAGALTDLFQRQLAAGVLTVDPGLKGLFARAAAAPDAPSGLPRPQSAPGAGQFSNLGLLHYALTHTRELPGPANWIHHRGHSGGSYAFGATPEEDRFALTHTPLAVWQEAVARLGSGLQPTALLRDLAAVWAGRTDVHRIDWAAIRADVVWVNAEFGRGDHDLGARLVRRGGARVDYRVVPGYGHGDVAWSATAERDVWEPLLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV4</accession>
    <name>A0A1E7NFV4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285745.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6714"/>
    <dbReference type="EnsemblBacteria" id="OEV39576">
        <property type="protein sequence ID" value="OEV39576"/>
        <property type="gene ID" value="HS99_0002535"/>
    </dbReference>
    <dbReference type="OMA" id="LAQWWGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="18152" checksum="845D749F2A790440" modified="2017-01-18" version="1">MTSTSTHETRIEADPTLPTIRIVREFDAPQERVFRAWIEPQLVAQWLGPEDLDMKIDDWDGRTGGHYRYSMHRDGQEVAAFYGSFHEVRPATRLVQTFTFEGVPDGVSLDTAVFEAVGEGRTRVTVLSVVDSLAARDAILASGMEHGVVEGYRKLDALLAGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG49</accession>
    <name>A0A1E7NG49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550426.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2841"/>
    <dbReference type="EnsemblBacteria" id="OEV39691">
        <property type="protein sequence ID" value="OEV39691"/>
        <property type="gene ID" value="HS99_0003235"/>
    </dbReference>
    <dbReference type="OMA" id="HRPDKFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="28179" checksum="F0B768EA729E2D5C" modified="2017-01-18" version="1">MKTSEDLPLHQRLGAEFQRRIESGEWPEGEPVPSESQLCAEFGTSRGPVRQALAMLRSAGSLVGGRGKPPVARRTTPSQPFDTFLSFTQWARSIGREPGQHTLEVARRRASPEAAVRLGLAQDEPVVELVRLRLLDGVPAMLERSTFVHEVGRILFDFDPDTGSVYQELLRREVDLHHARHTIDAVAAGPRDAELLRVDAGAPLLRVRRLTTSRLGVPLEDADDRYLPAMATFTIENTIEGRTVIGRYRTEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB2</accession>
    <name>A0A1E7NGB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550446.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000628.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2865"/>
    <dbReference type="EnsemblBacteria" id="OEV39712">
        <property type="protein sequence ID" value="OEV39712"/>
        <property type="gene ID" value="HS99_0003360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1036" mass="107462" checksum="7AEBCBC14F3F1243" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK4</accession>
    <name>A0A1E7NGK4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550296.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2727"/>
    <dbReference type="EnsemblBacteria" id="OEV39849">
        <property type="protein sequence ID" value="OEV39849"/>
        <property type="gene ID" value="HS99_0002665"/>
    </dbReference>
    <dbReference type="OMA" id="GGMEYAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199144" evidence="1">
        <location>
            <begin position="22"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="2">
        <location>
            <begin position="320"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="458" mass="49835" checksum="1C7828F3568366A0" modified="2017-01-18" version="1">MFAVLAVLLTAAAAPPGRAVATTPAATAGDPTRTPGAPAYTVDLSSDATGAHWHGHERITFSNVSPDPLQEVYLRLWDNFRGGCANPSVRVTGLGTTQVTQATLLPQDTRGRYEVGCTALRVPLPHPLTQGSSGTVEFDLTIDVPDGIDRFGRDGSFSFIGNALPVLAVRDEAGWHLDPYSELGESFYGLSSDFAVTLDHPTDLLVPATGTAVDTPGEPGRTLTRIGARKVREFAWAAGPFSRIAGRSADGVRIAVYSVADITPKDAQDMLDLSLRTIDAHSASYGAYPYGDLALVLDNRFDFAGMEYPGFVLDWIRPSAVIHELAHQWWYGIVGDDQYRAPWLDESFTEYAMAVAMGDTGEGCTTRTPWRSADERLTNPMSYWDTHPDRYVPVIYDHGSCALHELRRLIGADTMAGLLRDYARAHWYGVSTTADFKAAAQAATPVDLTPFWREHRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGU3</accession>
    <name>A0A1E7NGU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline D-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550416.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2833"/>
    <dbReference type="EnsemblBacteria" id="OEV39683">
        <property type="protein sequence ID" value="OEV39683"/>
        <property type="gene ID" value="HS99_0003195"/>
    </dbReference>
    <dbReference type="OMA" id="AHAYYRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="40009" checksum="473611715D6DFE1B" modified="2017-01-18" version="1">MSTTLSTATTSSDQDRPELRQAIEEIVESGVLGVQLLVTDERGEWVGSAGARELGSGAGPLTDGHFRIGSSTKSFVAGSVLLLVAEGRIELDAPAAQYLPAFGLDGRITVRMLLQHTSGVFSHTGELLADGTVVPGVAWQGKAWVDDRFRTYRPEELVRLSLSKEPRFAPGEGWSYSNTNYVLARLVIEEVTGRSFAEELQRLILGPLGMTGTVAPGASPELPEPHHHSYYRYQDGGQERTLDVTRHNPSWVAAGGDMISTTRDLHTYFSALMGGRLLPAELLGEMRTPEATIGYGLGVFAQETEGGTVYHHNGATIGSAALMYGSADGSRILTAGLNYVDDADLSLAGAFQKAQQLLVAEVFCGGQADPAPSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q75UM9</accession>
    <name>Q75UM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein tch-ORF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tch-ORF4</name>
        <name evidence="2" type="ORF">HS99_0039560</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2004" name="Biosci. Biotechnol. Biochem." volume="68" first="1345" last="1352">
            <title>Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Nakano T."/>
                <person name="Miyake K."/>
                <person name="Endo H."/>
                <person name="Dairi T."/>
                <person name="Mizukami T."/>
                <person name="Katsumata R."/>
            </authorList>
            <dbReference type="PubMed" id="15215601"/>
            <dbReference type="DOI" id="10.1271/bbb.68.1345"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">HP77</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AB125899">
        <property type="protein sequence ID" value="BAD16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289938.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000078.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene90"/>
    <dbReference type="EnsemblBacteria" id="OEV32900">
        <property type="protein sequence ID" value="OEV32900"/>
        <property type="gene ID" value="HS99_0039560"/>
    </dbReference>
    <dbReference type="OMA" id="EPFRGHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAD16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33748" checksum="A75D3595591B0EA6" modified="2004-07-05" version="1">MTGGSEAVRRWRPGFPLDPVRTLLPLRRGPADPSYRTTGDGAVWRASRTPAGIGTLRVLPRPAAGEVEATAWGPGAQWLLERLPVLLGAEDHPEALVLPPGPLRDAQRRTAGVRLTRTGLVLESLVPAILEQKVTTDEAYRAWRTLLRDFGTPAPGPAEGMRVAPSAREWAMVPSWEWHRAGVDPKRSATVIRAVRLAPRLEEASTMPHEQAFTRLTAVPGIGVWTAAETLQRSNGDPDAVSVGDFHLPNLVGWALAGRPRSDDSQMLALLEPYRPHRHRICRLLLATTAHAPRYGPRLTPNDHRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUZ9</accession>
    <name>A0A1E7MUZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550537.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2958"/>
    <dbReference type="EnsemblBacteria" id="OEV32256">
        <property type="protein sequence ID" value="OEV32256"/>
        <property type="gene ID" value="HS99_0016180"/>
    </dbReference>
    <dbReference type="OMA" id="WWAYSRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14661" checksum="445B288FC5220124" modified="2017-01-18" version="1">MTSTDLNRPDTRRAFRTVRRLVLAYLGVSALTLVAAFALRDHTDLITPAVWVRGTIVLAGAAVALLLTVRAARGSRGAFRRLRVVSGAMLVAIAAIIAVPGVFPVWMKIEQGFCGLALLGVAVVLNGRQLRALFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV97</accession>
    <name>A0A1E7MV97_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6952"/>
    <dbReference type="EnsemblBacteria" id="OEV32362">
        <property type="protein sequence ID" value="OEV32362"/>
        <property type="gene ID" value="HS99_0016820"/>
    </dbReference>
    <dbReference type="OMA" id="DHDSAHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13758" checksum="3AB522C217D712AB" modified="2017-01-18" version="1">MVDDRVSVRVVTVAGELDHDSAHVLRAALAQPLHDGVRRIVVDLAELRFCDSTGLNILLRARLDADAAGRTLEVSRPRPIVARLFEITGTDTLLRVRLDRDAEPGPPAPEAATDASPPASPPAASPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM2</accession>
    <name>A0A1E7MVM2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387134.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000691.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1230"/>
    <dbReference type="EnsemblBacteria" id="OEV32481">
        <property type="protein sequence ID" value="OEV32481"/>
        <property type="gene ID" value="HS99_0017535"/>
    </dbReference>
    <dbReference type="OMA" id="PWHKAAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="3">
        <location>
            <begin position="327"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="415" mass="43199" checksum="3D90BA6121A46A08" modified="2017-01-18" version="1">MTALREVAVVGAGAAGLHAAEALRRAGYDGRLTLIGAEDEPPYDRPPLSKHLLDGQWQPDRLALRSPDALAELRLDLRLGVPAERLDRQARTVHLADGHQVRCQAVVLATGVRPRRLPGAEAPLPGAHVLRTLADALALREELRPGTRLLVAGGGLLGAEAAATAVGLGAEVVWLVSAAAPLAAVLGAETAALLTGLHREHGVRIHRGTAAAVVRRRGRAAGVRLADGSELAADAVLMAIGSEPATEWLAGSGVPLDAGGGVACDAHCAAGPGVWAAGDAASWPDPRTGRRRRLEQRTNATEQALHAARNLLAGPDGARQAYAPVPYLWTDQYGLRIQAFGSPGTADRFELVDGSPADHRFAAACLHRGRVTGAVGIACARALRQLRAQVAAHAPWPPADPVTRQTADHAPARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS2</accession>
    <name>A0A1E7MVS2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385797.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1180"/>
    <dbReference type="EnsemblBacteria" id="OEV32530">
        <property type="protein sequence ID" value="OEV32530"/>
        <property type="gene ID" value="HS99_0017290"/>
    </dbReference>
    <dbReference type="OMA" id="HSHEEVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14570" checksum="9DFA161CB91AF0F6" modified="2017-01-18" version="1">MEALFHTVRRPDREQYTNEEVARACREATGESFSTTYLWQLRTGRRDNPTKRHLEALAHFFQVPPAYFFDERQGAEIAKELALLGALRDAGVRSLALRAVGLSPEGLDTVSELVDVIARRDAARKRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW01</accession>
    <name>A0A1E7MW01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290563.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1188"/>
    <dbReference type="EnsemblBacteria" id="OEV32443">
        <property type="protein sequence ID" value="OEV32443"/>
        <property type="gene ID" value="HS99_0017325"/>
    </dbReference>
    <dbReference type="OMA" id="MPDEWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="13698" checksum="9ACE8C6E44C5D925" modified="2017-01-18" version="1">MQEETARSAIDTFISAFNASDDSYVTALLPQALTSDVVFWGPLGRSEGIAAVERFVLDIRRHPAGTGTMVRCSAVDMPDEWARYRWVFTTPDGGPRLAGTDVVHLRRSLIDQIIVFAGEIEPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW50</accession>
    <name>A0A1E7MW50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000415.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3146"/>
    <dbReference type="EnsemblBacteria" id="ARF78302">
        <property type="protein sequence ID" value="ARF78302"/>
        <property type="gene ID" value="B6264_04665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32658">
        <property type="protein sequence ID" value="OEV32658"/>
        <property type="gene ID" value="HS99_0015415"/>
    </dbReference>
    <dbReference type="OMA" id="MRHPAVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="35690" checksum="F7AED99B5C6DAAE3" modified="2017-01-18" version="1">MWHNSYFVVPTVLLVAAVLYAAGTHQRVRHVARPQGLPGRGLPLLDTAFLAGGPGRVFDTALVRMHLSEQVVISRSNLVTLTGAKPYDAVDQAVHDAVGATGSRELGALRRMVMRSAAVQEIGDRLADRGLLRRPERMQRARTARRLLWLAMLDVVLFAGLALLLDDNDALHERPNLLIPGFLLLLGALGLATSTPAKGRITPAGQRQLSLMQGSTPWTPSSGVSPRLAGGAVLGALALGGLAVAGLENQELEQAMTAAAAQDEAMRQAQASSSFFSSSSSSSSSSSWSSSSSSSSSSSCSSSGYSCSATDSGSTHHHSSCGSSHSSCGSSHSSCGSSCGGGCGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWB8</accession>
    <name>A0A1E7MWB8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32721">
        <property type="protein sequence ID" value="OEV32721"/>
        <property type="gene ID" value="HS99_0015795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="12507" checksum="D9AB29D651FC96D5" modified="2017-01-18" version="1">MHRRAVRMPFYRGAPGSCWAASTVRCRSAVASRVAAQAAGEGEGVGAFVVEHGELVPDGLPQQGQGRPEPAGGACAAHGGAQGAHVRMLDTGGAVGRVRTGAFVGRIRTVGGQRAQCGPCGRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD5</accession>
    <name>A0A1E7MWD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285543.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000387.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7819"/>
    <dbReference type="EnsemblBacteria" id="ARF78210">
        <property type="protein sequence ID" value="ARF78210"/>
        <property type="gene ID" value="B6264_04135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32746">
        <property type="protein sequence ID" value="OEV32746"/>
        <property type="gene ID" value="HS99_0015945"/>
    </dbReference>
    <dbReference type="OMA" id="GLYWKTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="20299" checksum="A22B26ADBA7B834A" modified="2017-01-18" version="1">MTRQPLLLLDVDGPLNPYAAPRLRRPAGYRSHELMPAWWAERQARRAEGEAKPLRVWLNPAHGVELLALPYELVWATTWMAEANALIGPNLGLPELPYIAWTELFGSDPDGLHWKTRDVVAWADGRPFVWLDDELGPQDIEWIAANHPGEALPLWVDPRAGLHELHFAALREWAEEAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP5</accession>
    <name>A0A1E7MWP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fic family toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000082">
        <property type="protein sequence ID" value="OEV32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291066.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000205.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000098_gene33"/>
    <dbReference type="EnsemblBacteria" id="ARF80367">
        <property type="protein sequence ID" value="ARF80367"/>
        <property type="gene ID" value="B6264_16935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32851">
        <property type="protein sequence ID" value="OEV32851"/>
        <property type="gene ID" value="HS99_0039845"/>
    </dbReference>
    <dbReference type="OMA" id="RHQAEIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15285" checksum="AD6A8430622851A4" modified="2017-01-18" version="1">MKLEVDLSWLLMTAEQYTPGDPQVTDYGSLLAAVTRHQAEIFDISVYPEPQDRAAALMHQLIRVPALEKTNELFATAVAYAYLVASGCTVATTAREVRSLSRAIREGRLGVSGVAERLAAWVVDEAEGEGVSGADDEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY4</accession>
    <name>A0A1E7MWY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552528.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000640.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5758"/>
    <dbReference type="EnsemblBacteria" id="ARF81366">
        <property type="protein sequence ID" value="ARF81366"/>
        <property type="gene ID" value="B6264_22845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32956">
        <property type="protein sequence ID" value="OEV32956"/>
        <property type="gene ID" value="HS99_0013815"/>
    </dbReference>
    <dbReference type="OMA" id="ECEDVPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="41129" checksum="FCBC93EB04EAE09E" modified="2017-01-18" version="1">MGLTSHKLLALAALLAVFTVLGTLWVWPKLAVRSWPAMFLRLGTLAVTQLSLLVVFGLAVNDYFVFYSSWSDLLGHEHGAGVIQGAGGTPRATTPSGGPAAPSGPAAPTGPAGVQVLGTAKITGAGSVSRDPARIGRLDRVRLPGGTTGLSTDGYVYLPPQYFQPGNETEHFPAVLVMTGFPGDAANLVTKLRYPATELDLLDKGTMKPTVLVLMRPSPSMPRDSECEDVPYGPQAQTYFSTDVPADLRAGYRVLGGAGSLGVMGDSTGGYCAVKLGMAHPGTFPAAVSLSGYFKAAEDVTTGDLFGGSQQRRSEADLNWRLTHLPVPALAVLLADSKQDGRTYADSTAFAAAARPPLVVAQATVGTGGHNFTTWDRLIPPSLSWLSARLPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ8</accession>
    <name>A0A1E7MXZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7026"/>
    <dbReference type="EnsemblBacteria" id="ARF80421">
        <property type="protein sequence ID" value="ARF80421"/>
        <property type="gene ID" value="B6264_17245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33320">
        <property type="protein sequence ID" value="OEV33320"/>
        <property type="gene ID" value="HS99_0012015"/>
    </dbReference>
    <dbReference type="OMA" id="RWHRPVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20443" checksum="8BE442EF0DDB4A84" modified="2017-01-18" version="1">MAEDVGGLPYPDGADHGGADDEFATVVFDEAFVRSAAVHEPTARERQLAAAEARFEPDTAGSGWSFDFPAGDGLPLELRPYPSGLDEDHLYPDPWSGPVRATGCRGRRWGRRYDPVRARGRYVAQQRWHRPVAWVLAVIMGVSLVAVAVAAVYQGVGGAAGAPRRPESGSSSPGADPRSAPAEPLPVVTARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY74</accession>
    <name>A0A1E7MY74_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366801.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3995"/>
    <dbReference type="EnsemblBacteria" id="ARF80497">
        <property type="protein sequence ID" value="ARF80497"/>
        <property type="gene ID" value="B6264_17685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33395">
        <property type="protein sequence ID" value="OEV33395"/>
        <property type="gene ID" value="HS99_0012460"/>
    </dbReference>
    <dbReference type="OMA" id="EDSRWIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063897" evidence="2">
        <location>
            <begin position="33"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="336" mass="33616" checksum="264D2848A0B7A346" modified="2017-01-18" version="1">MPRTTRPAVVVTAGLAALLLAGLAGCSGGGGADGSDGSDRGFAGALPGRAPAGATPTPTPTPPSGPYVALGDSYTAGPKIAPQVGEPGGCGRSGVNYPALVAKALALAPGQFRDVSCSGARTGDLKAVQKTDDGANPAQLDALTPATRLVTLGIGGNDAGFMQVMTECAKDTLVGAVKDLVGGKTSAAPCREHYASGGADQLQARVDEAGGKVADVLREIRRRSPQARVYVVGYPALLPTDPVSCGPVLGTTIAAADLGFLAEKERQLNGMLKQRAEAAGAVFVDTAGPSAGHDMCAGEDSRWIEPPFPAHGLTPIHPNAKGQEAVAGVVLKAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY90</accession>
    <name>A0A1E7MY90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0012535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553436.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3983"/>
    <dbReference type="EnsemblBacteria" id="ARF80506">
        <property type="protein sequence ID" value="ARF80506"/>
        <property type="gene ID" value="B6264_17760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33402">
        <property type="protein sequence ID" value="OEV33402"/>
        <property type="gene ID" value="HS99_0012535"/>
    </dbReference>
    <dbReference type="OMA" id="YHFGGYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="31661" checksum="CC5010E71886A629" modified="2017-01-18" version="1">MLEPALLPTPLVDCTDEAFARAGVELRLKRDDLLHPSVPGNKWRKLAPNLAVAVEHGHTRLLTFGGAYSTHLRAVAAAAGALGLESVGLVRGEELADRPRNWSLRAAEESGMRLEFLTRAAYREATGRAGDGDGAEVQRRWGPCLVLPEGGSNALAAVGAAAIPAELPDLDRRDVVCCPVGTGGTLAGIAAGLPPGARALGVAVLRGGEGYLEAEVARLHRAGFGREFANWRIDHGHHGGGYGKVPPELAAFAGEFERRHGIPVERRYVAKLLAALADLAGAGAFPRGTRLTAVVTGLPDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC8</accession>
    <name>A0A1E7MYC8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386994.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000607.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3962"/>
    <dbReference type="EnsemblBacteria" id="ARF80526">
        <property type="protein sequence ID" value="ARF80526"/>
        <property type="gene ID" value="B6264_17865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33421">
        <property type="protein sequence ID" value="OEV33421"/>
        <property type="gene ID" value="HS99_0012640"/>
    </dbReference>
    <dbReference type="OMA" id="HHMSVIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="47346" checksum="5D604E9167D3C39D" modified="2017-01-18" version="1">MKTLTTADARGFAMRQLRTLRHHLTTPSDDHTPLLGDSRRPWVRRLPYIVVVILQAVLIPTGIANLVNFYGLVLPVAAALTVSQTIPLFLAITRPLAAWWISAATLVTTAAITARHHQVEGSWPWTAPMILSYLFLLLALGLRERRATVIAVWVATFLLTVLTTTLGLPRAGDGTTVLLIALSGAVLLLGWAVRDRTVARRLLTEQEQISEVERERRTLLEERARIARELHDVVAHHMSVIAVQAASAPYRIEGVPAAAAEEFTAIAGTARESLAEMRRLLGVLRSEESAGETAPQPGVGQLAQLVETVGRAGVPAELTVDEGLTERVPQAVGLSAYRIVQEALANVVRHAPGARTWVSLSADGPELRLTVVNAAPPQRTESLEASVEGTGHGLVGMRERVRLVDGRLDTGPLPDGGFKVAAVLPLDPSDRPGTPGEKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYH9</accession>
    <name>A0A1E7MYH9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282358.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000252.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5172"/>
    <dbReference type="EnsemblBacteria" id="OEV33500">
        <property type="protein sequence ID" value="OEV33500"/>
        <property type="gene ID" value="HS99_0013120"/>
    </dbReference>
    <dbReference type="OMA" id="CQGCRQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="27348" checksum="17960135D4065C82" modified="2017-01-18" version="1">MNAAPADQIRLLDLQAIDSKLDQLAHRRRGLPEHAEIDKATADHTALKDLVIAAEAQKGDTARELAKAEQDVEQVRARAARNQQRLDSGAITSPKDLENLQHEIGSLAKRQGDLEDVVLEIMERQESARTRVEELSARLEHSTVVLKEAEARRDAAFAEIDGEADKVRRDRETVAAVIPADLLKLYAKLRETQGGVGAARLYQRRCEGCRTEFSITELNAIKAEPADKVVRCENCSRILVRTADSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI2</accession>
    <name>A0A1E7MYI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside/nucleotide kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289995.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000630.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3272"/>
    <dbReference type="EnsemblBacteria" id="ARF80306">
        <property type="protein sequence ID" value="ARF80306"/>
        <property type="gene ID" value="B6264_16565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33293">
        <property type="protein sequence ID" value="OEV33293"/>
        <property type="gene ID" value="HS99_0038745"/>
    </dbReference>
    <dbReference type="OMA" id="WRIEYND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24714" checksum="1E9E75C3C8293C5D" modified="2017-01-18" version="1">MNEDRLTALALGLLRGPGSNARTILGLAGPPGAGKSTLARHLVAEVERVEGPGTAAYLPLDGFHLSAAQLDRLGLTHRKGAPATFDAHGYVALLRRVAADRFQDIYVPDFDRTLDEPVAARHVVRPHTRLVITEGNYLASAETPWPDARRLLRELWYVDTEDTVRRERLLRRHREGGRDEATALHWVTTNDHPNGEYVKQGRALCTRTVPGAGLRRAEHGGSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYL1</accession>
    <name>A0A1E7MYL1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="4" type="ORF">HS99_0013185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282535.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000357.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5185"/>
    <dbReference type="EnsemblBacteria" id="ARF80612">
        <property type="protein sequence ID" value="ARF80612"/>
        <property type="gene ID" value="B6264_18405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33509">
        <property type="protein sequence ID" value="OEV33509"/>
        <property type="gene ID" value="HS99_0013185"/>
    </dbReference>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="30729" checksum="902586EA788B8119" modified="2017-01-18" version="1">MALVPGIQSPTRKVPAHIARPEYVGKPAPTPYTGPEVQTAETIEKMRIAGRIAARAMEEAAKLIAPGVTTDALDAVAHAYMCDHGAYPSDLGYRGFPKSVCTSINEVICHGIPDSTVLQDGDIVNIDATAYIHGVHGDLNATYLVGDVDEESRLLVERTRESLNRAIKAVKPGRQINVIGRVIESYAKRFDYGVVRDFTGHGINTSFHSGLIVPHYDSERATEVIKPGMTFTIEPMLTLGTYDYEIWPDGWTVVTKDRKRTAQFEHTLVVTADGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYW6</accession>
    <name>A0A1E7MYW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737980.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33626">
        <property type="protein sequence ID" value="OEV33626"/>
        <property type="gene ID" value="HS99_0038680"/>
    </dbReference>
    <dbReference type="OMA" id="DPRTWET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="22250" checksum="FF3B3C0172A09776" modified="2017-01-18" version="1">MALTLDEAVEQLGHRLSPKRRSAATRLRRLADPVAGPPLLDALEREVRDPRTWETQYQMVMALGMCGHRPALGLLRDLAQRPFEATMVYTALGDAIMRLSAPEATADSLRWCLDSGTPMLADGALRAVAMQRLRPDTTTIDHVLDLLGPLGPHDGLRFWAAAAAAGWPGPRVQEFLRDCAAGPRTDVASAAASSLRGKYQTCTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYY6</accession>
    <name>A0A1E7MYY6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="10" type="ORF">HS99_0038550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286425.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1096"/>
    <dbReference type="EnsemblBacteria" id="ARF78981">
        <property type="protein sequence ID" value="ARF78981"/>
        <property type="gene ID" value="B6264_08675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33639">
        <property type="protein sequence ID" value="OEV33639"/>
        <property type="gene ID" value="HS99_0038550"/>
    </dbReference>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="8">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="8">
        <location>
            <begin position="161"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="9">
        <location>
            <begin position="389"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="314"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="539" mass="59554" checksum="CA22B2A56D95C3D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ76</accession>
    <name>A0A1E7MZ76_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7708"/>
    <dbReference type="EnsemblBacteria" id="OEV33738">
        <property type="protein sequence ID" value="OEV33738"/>
        <property type="gene ID" value="HS99_0037995"/>
    </dbReference>
    <dbReference type="OMA" id="QYNTGRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30384" checksum="AA8E35BE41B479D4" modified="2017-01-18" version="1">MARRSYAKFGNADYGIWYRFAAVLVKPVTTALVKPDWRGWEHIPKEGGFIAAVNHNSIIDPVIYAHWQYNSGRPPRILGKSSLFSIPFIGFMLRKTGQIPVFRESTDAAQAFRAAIDAVNNGQCVQFYPEGTLTRDPDLWPMTGKNGVARVALMTGAPVIPVAHWGAHEIIPPYGRAGYGKGKFNLFPRHRVTVAAGPAVDLSRYRGQELTAQVLNDATEDIMAAITAVLAGIRGEQPPAERYDMRRAARERAAAALAERRRAKGGPDDNDGEGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA1</accession>
    <name>A0A1E7MZA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554873.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7689"/>
    <dbReference type="EnsemblBacteria" id="ARF78554">
        <property type="protein sequence ID" value="ARF78554"/>
        <property type="gene ID" value="B6264_06180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33756">
        <property type="protein sequence ID" value="OEV33756"/>
        <property type="gene ID" value="HS99_0038090"/>
    </dbReference>
    <dbReference type="OMA" id="REVPVCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063904" evidence="2">
        <location>
            <begin position="34"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="450" mass="47292" checksum="5CEAC9621B02139E" modified="2017-01-18" version="1">MRTLARRSRGAGPLALVAALLGLLLLLAPAASAAGGLSDAAATLKKGQVYVAPTMQDRFSQAQADALTKKIEKADKPIFIAVVPDAANKDTVLTDLRTLVGIDGVYGVWRGTSGFMARSDRGAMAAGAADRIGGAVARADKGDINATLNDFVDQAAPQTKGTGVNHSTSIAWVIIPVVLVALAGAGVFFLFRRAKKRKEEQARAELEQLRRVVDEDITAFGVELERLDFNPGAADADDAQRTDYSHALDSYEKSKRLMAEARKPEDVKQVTEAIEDGRFQLATLAARREKRPLPERRPPCFMDPRHGPSVKDVDWAPAGGSARPVPVCQADADRVAAGLDPAVRTVDTEYGPQPYWNAGPAYAPYAGGYYSGFGGGGLLPGLLVGTVLGSMMSSPAYAAAPMMEGGHGGHGGYQDQYEGGDYTGADFNAADFGGSDWSGGGDFGGGGDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM6</accession>
    <name>A0A1E7MZM6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="1">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="1">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sucC</name>
        <name evidence="2" type="ORF">HS99_0038420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000303.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4931"/>
    <dbReference type="EnsemblBacteria" id="ARF80000">
        <property type="protein sequence ID" value="ARF80000"/>
        <property type="gene ID" value="B6264_14750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33663">
        <property type="protein sequence ID" value="OEV33663"/>
        <property type="gene ID" value="HS99_0038420"/>
    </dbReference>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="1">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="40755" checksum="6A64C01C0BF0DEA4" modified="2017-01-18" version="1">MDLFEYQARDLFAKHGVPVLDGDVIETAADAAAIAERFGGRAVVKAQVKVGGRGKAGGVKLAADPQDAVAKAEQILGMDIKGHTVHKVMLAQTADIKDEYYVSFLLDRTNRTFLAMASVEGGVEIEVVAEQNPEALAKIPVDANEGCTPEKAAEIVAAAKFPAEVADQVAEVLQKLWKVFIAEDALLVEVNPLIKSGDGKIIALDGKVSLDENADFRQPEHEALEDKAAANPLEAAAKAKGLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMANGLEIILGDPDVKSVFVNVFGGITACDAVANGIVQALELLAGKGENVTKPLVVRLDGNNAELGRKILDDANHPLVQRVDTMDGAADRAAELANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV3</accession>
    <name>A0A1E7MZV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0010835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280319.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000829.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2172"/>
    <dbReference type="EnsemblBacteria" id="ARF77804">
        <property type="protein sequence ID" value="ARF77804"/>
        <property type="gene ID" value="B6264_01675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33951">
        <property type="protein sequence ID" value="OEV33951"/>
        <property type="gene ID" value="HS99_0010835"/>
    </dbReference>
    <dbReference type="OMA" id="FYDTATW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9290" checksum="EB28AA6CF2FB4286" modified="2017-01-18" version="1">MSIIAWIVLGLVAGALAKLLLPGRDPGGLIVTTLIGIAGSFVGGWIASHFMHRSITARFFDGPTWVSAIGGALVLLIAYRLLFGNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L8</accession>
    <name>A0A1E7N0L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285680.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6066"/>
    <dbReference type="EnsemblBacteria" id="ARF78156">
        <property type="protein sequence ID" value="ARF78156"/>
        <property type="gene ID" value="B6264_03815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34240">
        <property type="protein sequence ID" value="OEV34240"/>
        <property type="gene ID" value="HS99_0036915"/>
    </dbReference>
    <dbReference type="OMA" id="NPKIHTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="8323" checksum="B2066582D9B606B3" modified="2017-01-18" version="1">MDTPQTPICSAKGCRADARWVLVWNNPKLHTPDRRKTWLACEEHREHLSQFLGVRGFLKEVVAFADWTSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W5</accession>
    <name>A0A1E7N0W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000251.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6406"/>
    <dbReference type="EnsemblBacteria" id="ARF78727">
        <property type="protein sequence ID" value="ARF78727"/>
        <property type="gene ID" value="B6264_07165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34326">
        <property type="protein sequence ID" value="OEV34326"/>
        <property type="gene ID" value="HS99_0036370"/>
    </dbReference>
    <dbReference type="OMA" id="TFNPVRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="761" mass="82901" checksum="9F2DA7564703474D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y8</accession>
    <name>A0A1E7N0Y8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 6-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0036135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.132" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283370.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3905"/>
    <dbReference type="EnsemblBacteria" id="OEV34357">
        <property type="protein sequence ID" value="OEV34357"/>
        <property type="gene ID" value="HS99_0036135"/>
    </dbReference>
    <dbReference type="OMA" id="KYADNAF"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047919">
        <property type="term" value="F:GDP-mannose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028358">
        <property type="entry name" value="GDPman_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500135">
        <property type="entry name" value="GDPman_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="10">
        <location>
            <begin position="317"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500135-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="46560" checksum="CC4476C8DD17692C" modified="2017-01-18" version="1">MRISVLGLGYVGCVSAACLAGLGHEVIGVDVNQVKVDLVNDGRAPVVEERIGELIAEVVRTGALRATGDVREAVMGSEVSLVCVGTPSEPNGSLCTTYLERVAEQIGAAVAGRGGRHTVVFRSTMLPGTCLNLLVPILEKHAGGTAGTDFGVAVNPEFLREGTSVRDFFDPPKTVIGELDPASGDVVAALYEGLPGEVFRVPVPTAEAIKYADNAFHGLKIGFANELGAVCQALGVDSHQVMDVFLADRKLNISPAYLRPGFAFGGSCLPKDLRSLVHAAQRADVSVPILSHVLPSNSDHLQRAVELVERTGKRRVGLFGLSFKPGTDDLRESPLVELAERLFGKGYELRIYDPNVNLSRLLGANREYIETRLPHLAQLLAQSVGEVLDHAEVCVVGTRDPAVLSALPHGDDPVIVDLVHLPDADARRAEPGYAGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N170</accession>
    <name>A0A1E7N170_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289794.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1406"/>
    <dbReference type="EnsemblBacteria" id="ARF79243">
        <property type="protein sequence ID" value="ARF79243"/>
        <property type="gene ID" value="B6264_10240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34425">
        <property type="protein sequence ID" value="OEV34425"/>
        <property type="gene ID" value="HS99_0036060"/>
    </dbReference>
    <dbReference type="OMA" id="WIDLMAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="27828" checksum="95E495BB9E228BA1" modified="2017-01-18" version="1">MPVVTDPYKPGTPCWIDLMASDQQAALDFYRDLFGWQGEIGPAEFGGYAVCTLGGRPVAGIMAQSGPEGQPLPPVAWTTYLASDDVDAARAAIAGAGGTVLYDPMDVGALGRMMVAADPTGAVFGVWQAMDFIGAGVVNEPGALVWNELNTADTGAAGGFYQSALGLRPATIQGMDGYYSLNVGDRTVGGMQEIPKYLDAGTPSHWMPYFSVDDTDSVVDALVKQNGTVVQPPFDMQSGRMAVVKDPQGAVFAVIQAPEAQLPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B6</accession>
    <name>A0A1E7N1B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597002.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7062"/>
    <dbReference type="EnsemblBacteria" id="OEV34489">
        <property type="protein sequence ID" value="OEV34489"/>
        <property type="gene ID" value="HS99_0035410"/>
    </dbReference>
    <dbReference type="OMA" id="RVFCDAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="35833" checksum="FD2BF6DF0B5CC0CC" modified="2017-01-18" version="1">MNEVDIAVVGGGIIGCLTARELLARRPERTVAVLDRDSVGSGASRRSAGLHFPRGATGRVRGMAAYSQQYYAELSSHRPELPIHQVGMDVVGAEQTVRRSYLASARPTPATAGVWQVEGGQYADVSGLTGRLASELRGGAVVHEGTGVTAIGLDPERITLALSSGGELTVGQVVLAPGPWIAAPAWRELVAPLGVRVKKVVALHIDLVPAPTDRVVVFQAEDAFLLPLHDRGHWLFSYTCQEWGVDPDALGEGLSDQDLGDALAVLRAVAPEYAAHCASGRVFCDAYSGTGEPIVCPLPADPRVVFAGAANGSGYRLAPAIAAQAADLIDIPFLTSPTRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1T7</accession>
    <name>A0A1E7N1T7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000792.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4257"/>
    <dbReference type="EnsemblBacteria" id="ARF81994">
        <property type="protein sequence ID" value="ARF81994"/>
        <property type="gene ID" value="B6264_26705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34641">
        <property type="protein sequence ID" value="OEV34641"/>
        <property type="gene ID" value="HS99_0009085"/>
    </dbReference>
    <dbReference type="OMA" id="TWARERF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="44925" checksum="5728630CAB1F5D0E" modified="2017-01-18" version="1">MRQRPKLVLVGQFSALPWVFEGAERAGVDLILAPRGDDDPERARKAPGVVELLPLDVDGDPDAAVAALVERFARQPFDGIMAGNEKVVPFVARAARVLGLTGLTEEAAAVVRDKRSMRRLLAAAGLAVPGFVAVGHPDDWADAAGLRFPVVVKPADGYSSLGVIRVDSAGELEQAVRTTWALCDTHLGYDDGAADGTGVLVEEYLDGPEISAESLVHRGRVRVCAVSYKGELNGPYFEETTLRAPARLPADVLAAVEREVVGAHHAFGVTEGTTHTELRLVSGTRPVLLEMGARIGGGGFMHHLVHVSSGIDLAAEAVRIHLGREPECWSTEPVGTGHAAAYLVPVGGGGRIARVHGLDEVREEPCVDHVVRTVGPGALLRPYPDWSGYPAIVLSHHASDAAAVEFRDHLARTLRVEYDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W2</accession>
    <name>A0A1E7N1W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34656">
        <property type="protein sequence ID" value="OEV34656"/>
        <property type="gene ID" value="HS99_0009175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8783" checksum="E31DA364519F0C4A" modified="2017-01-18" version="1">MPRQHVEEIPDGDGGTVEVKLGLWISNTNSRRAKLAGEQLDQFVRSGSTGAETGRAQRPPRRAPGRPCPPVPVVSEEQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W7</accession>
    <name>A0A1E7N1W7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558402.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34688">
        <property type="protein sequence ID" value="OEV34688"/>
        <property type="gene ID" value="HS99_0009370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10904" checksum="42BE163DB41FDD0A" modified="2017-01-18" version="1">MLVARRPDGWEVSGVIDVENAIAADPLIDLAKTDYYSLGRGEPECSALFEGYGPLPADAVERLELYRLYHAVELWDWFRSIGTVGPVGGIADDIVRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N234</accession>
    <name>A0A1E7N234_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4611"/>
    <dbReference type="EnsemblBacteria" id="ARF81890">
        <property type="protein sequence ID" value="ARF81890"/>
        <property type="gene ID" value="B6264_26070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34747">
        <property type="protein sequence ID" value="OEV34747"/>
        <property type="gene ID" value="HS99_0009700"/>
    </dbReference>
    <dbReference type="OMA" id="HITYFAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="SSF48056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="33387" checksum="64B089056319C1F7" modified="2017-01-18" version="1">MTIDQTTTAERPFGGRFPDRAELRRLQDSWGLQPTLDPEAAAVRFDRHVASFQPEPNGTIPEQVPAEVARNFVMQLASSLTRVRIDHRNLDQAGRDRFNRALQQVHASGAYEQLAAVHADMSHRMHSMSGPVGTQRFLPWHRRYLLELEDLLRSVQPALTVPYWDYANDHARPDWVWRPPNVVRDTPGAAGGSLPTQAIIDGLLARPRYNPFTSHLETDAHNQVHNWCNGTISDIMESAHDPIFWLLHANVDHIWDGWQLNHTGKPSLTGKDAVLDPWTSTASDVNSTTILGYSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N252</accession>
    <name>A0A1E7N252_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Group II intron reverse transcriptase/maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555849.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4605"/>
    <dbReference type="EnsemblBacteria" id="ARF81886">
        <property type="protein sequence ID" value="ARF81886"/>
        <property type="gene ID" value="B6264_26040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34751">
        <property type="protein sequence ID" value="OEV34751"/>
        <property type="gene ID" value="HS99_0009725"/>
    </dbReference>
    <dbReference type="OMA" id="WVFGDRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="600" mass="66913" checksum="E9C1BE2D5BE096EE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N270</accession>
    <name>A0A1E7N270_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3251"/>
    <dbReference type="EnsemblBacteria" id="ARF81855">
        <property type="protein sequence ID" value="ARF81855"/>
        <property type="gene ID" value="B6264_25830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34784">
        <property type="protein sequence ID" value="OEV34784"/>
        <property type="gene ID" value="HS99_0009915"/>
    </dbReference>
    <dbReference type="OMA" id="CFVTASW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="491" mass="49188" checksum="CA5D3C580088FD9B" modified="2017-01-18" version="1">MAAGGGTLAALLPGGWGAVGFAVPAVLLAVAGAARLRRRPLDSPVVPVGLLTVAGAVLLVTSAASLAQLFPGVVEPAAHWQAAWEGTRAVQGSQSTPAAALTALWLLVAAGVAVHLLGLRGSATAGAEAALSAVASFALALLPVAFGLSPVMAVGFVTALALVGGWFLPVRAALIAGVILSGTLALLWALANRPSTIVVLALAAGLTVALTVRGCPAPAVTAVLAVAALGGEAAAVAVTAGLERPDHLLAVLAVALATAPVAARLAARTDSAVPAAVEFAGYGMAALVLLLSADVPGRLSFELAVTGAAALGVGLRADRRRSAPAVGVALLIAASWLWLALADVHAPEAYSLSLAVAALVFGHLRRGRFAEEGLGSWPVYGPGLAVGLLPSLWALFLDGYWLRPLLLGVAALVVTVLGVRLRLQCPLVLGGGVLVLVAGHELAPTVVQVLGLLPRWVPLAAAGVLQLALGATYEQRLRDARRLHGALRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G5</accession>
    <name>A0A1E7N2G5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0008850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34870">
        <property type="protein sequence ID" value="OEV34870"/>
        <property type="gene ID" value="HS99_0008850"/>
    </dbReference>
    <dbReference type="OMA" id="DHVTLWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198686" evidence="2">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="48453" checksum="6D6CDB4E0293809C" modified="2017-01-18" version="1">MILATALLASVSAIAPAIAISGGGAPSPAPTRPGSSSNKKIPAGGTTAAALAEVTKPETLELMKKQEALDKVVDRIVGGREEHARDRIPGFSEVEVDPGANRITLHWKGELPDAVRGVLQDLPGGVSVQVVPAKYSKAELHAAREKLLSNGKPVPLAAKRASHISSIGPSLDGSGLDLGYEADDERVPGALLAPLSTEELTPQVEAIASAVAGVEVHARHQKTVVDLSRGADSEPWYGGAGVLTPGGTICSTGFGVYKPADMYKSLVTTAWHCGAGSYNTWYSQQYMGYANEGDGNAADDTIGIVPRDSQKSGGYVYTLAWNEPSDYAMQVSGSGGNNVGDYVCQSAANSGAHCNIRVAQVDRQILGPNGVWRKFADEAVQTDPNNIAAANGDSGGPVFVTSDNGTKIQARGTITSLESEQDCAGRQTADGGWRTPWCFHGMWYVPISQTLADMGWVLRTSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H2</accession>
    <name>A0A1E7N2H2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4226"/>
    <dbReference type="EnsemblBacteria" id="OEV34876">
        <property type="protein sequence ID" value="OEV34876"/>
        <property type="gene ID" value="HS99_0009225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198701" evidence="1">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="21016" checksum="ADE7B4686F2EC884" modified="2017-01-18" version="1">MFGTGAVGALILTAPAAHAQTARAAYTVIVPCSETALVSAVNAANAAGGGALILAPFCTYSLTSAHSSGGAGGPAGLPNITTPVTMTGLATQITRAPGAAAFRIIEVDGPSHLPADNGQLALTAVAISNGDAGFGVGGGIANLGGSVVLIGGGVSNSRASFGGGIYTDTALTMTTSSVTGNTATVDGGGIYQNAGSVALVGTNASGNTPDNCAATPPLTAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N6</accession>
    <name>A0A1E7N2N6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830700.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7677"/>
    <dbReference type="EnsemblBacteria" id="ARF78542">
        <property type="protein sequence ID" value="ARF78542"/>
        <property type="gene ID" value="B6264_06115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34958">
        <property type="protein sequence ID" value="OEV34958"/>
        <property type="gene ID" value="HS99_0034645"/>
    </dbReference>
    <dbReference type="OMA" id="WGPPERC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="24840" checksum="0950D5B48E6AE182" modified="2017-01-18" version="1">MLVPLYEAVYDRLEVGPASSVLGLGCRSGLALLLAAGRGAQVSGQEPREELRELARDRRLRVCAGARPAAAVPRSAHSLVTVFDQLPGAADPGRVVAEAARLTLPGGHVVLAAWGPQERCESAPVLDAARRMAGRTTARDPFELSVPGALEDLLAPVGLRPAGSGRVSCPFAYPDLDSAVRGLLSTGLFEPAEEFSGAPLVAKELEEALQPYLRPDGSVRMENVFRYLVAERPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z9</accession>
    <name>A0A1E7N2Z9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366595.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene433"/>
    <dbReference type="EnsemblBacteria" id="ARF78872">
        <property type="protein sequence ID" value="ARF78872"/>
        <property type="gene ID" value="B6264_08045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35071">
        <property type="protein sequence ID" value="OEV35071"/>
        <property type="gene ID" value="HS99_0033950"/>
    </dbReference>
    <dbReference type="OMA" id="GDREITC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4190" evidence="1">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="238"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="478" mass="50417" checksum="70F2DC98F91A67BA" modified="2017-01-18" version="1">MSKPESELPAAPGPDPRVDFRKDPDTAEPKAGEPKAGIPDTAEPEAATPDAEEPQDPADPWAPPADRPAQAAPAPSQAPPQPPPPPLPAGGWASVPPSAESGFRPGDPYPNPDPRSNQHPYPPYAHHPYNPQPEPRTNGFAVGSLATGLSLLSPVALVFGIVALVQINRRGQRGRGMAVTGLVLGVAGTLLLSLALGAGDFGPARGGPGGGYAQKPPAGSVRWSALKAGDCYNSPDVTGKTDENGDETVYWVRRVVCSDPHHGEVAGTARIPDSSGPYPGATVVRERATTLCRTVLDDYALDQWAVPDGMDDVYLYPSAGNWAAGERYVTCAFEDRDDQHLGTVRTDRRTLTSVQLAYLDAVRGFGAVYADEPKKDVAVAEAEYRSWARRMAAASRAEAAALRKPTAEWPTDIQPKVDKLAATQTQAATAWDAAASGDDVPGDLRRARALTAKTVPVSVEIRRALGLSTGEQVPDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N343</accession>
    <name>A0A1E7N343_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0034105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554318.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000600.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene405"/>
    <dbReference type="EnsemblBacteria" id="ARF78898">
        <property type="protein sequence ID" value="ARF78898"/>
        <property type="gene ID" value="B6264_08195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35095">
        <property type="protein sequence ID" value="OEV35095"/>
        <property type="gene ID" value="HS99_0034105"/>
    </dbReference>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="20421" checksum="3276832336863A30" modified="2017-01-18" version="1">MLTIGDKFPEFDLKACVDLDAAGAFADIDHKTYEGKWKIVFFWPMDFTFVCPTEIAAFGKLNDEFADRDAQILGVSGDSEFVHHAWRKDHKDLRDLPFPMLADIKHDLMRACGVEGEDGTAQRAVFIVDPNNEIQFVMVTAGSVGRNPKEVLRVLDALQTDELCPCNWNKGEDTLDAQALLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N353</accession>
    <name>A0A1E7N353_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">HS99_0034160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene392"/>
    <dbReference type="EnsemblBacteria" id="ARF78908">
        <property type="protein sequence ID" value="ARF78908"/>
        <property type="gene ID" value="B6264_08250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35105">
        <property type="protein sequence ID" value="OEV35105"/>
        <property type="gene ID" value="HS99_0034160"/>
    </dbReference>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="22"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="389"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="275"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="517"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="608" mass="66673" checksum="0204F1B8DE07D7F0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B0</accession>
    <name>A0A1E7N3B0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386694.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000463.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4476"/>
    <dbReference type="EnsemblBacteria" id="ARF78427">
        <property type="protein sequence ID" value="ARF78427"/>
        <property type="gene ID" value="B6264_05380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35170">
        <property type="protein sequence ID" value="OEV35170"/>
        <property type="gene ID" value="HS99_0033875"/>
    </dbReference>
    <dbReference type="OMA" id="WFPEAGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="418" mass="42099" checksum="2798312C68A207AF" modified="2017-01-18" version="1">MLSSYRRIFAAPGTLAFSSAGFVARLPISMAGIGIVTMLSQLTGSYGLAGAVSATMAVAAAALGPAVSWLVDRRGQRHVAVPATALTVAAATGLLLCAHFHAPSWTLFLFAVGLGVMPSAGAMVRARWAHLYRDAPAKLHTAYSFEAVVDEVCFIVGPILAIGLATNVFPESGVLVAVVALAVGIALFTAQRRTEPPVHPASAHGGGSAILNGGLIVLVLTFVATGAIFGSVEIVTVAFADAQGHKGLSSIVLAVWAVGSGLAGVVYGALKPRSPLSTRFFVGVVMMALSMVPILLVASTVHGVGGLVAAGAALLIAGVAISPTLISAMALVERLVPAAKLTEGMAWTTTGLALGVAFGSSVGGWVVDASGAPSGYWVPLTAGALGVLVALTGLGRLRAGVTANEQVEAVERPVDAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N428</accession>
    <name>A0A1E7N428_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000602.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1373"/>
    <dbReference type="EnsemblBacteria" id="ARF79274">
        <property type="protein sequence ID" value="ARF79274"/>
        <property type="gene ID" value="B6264_10405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35213">
        <property type="protein sequence ID" value="OEV35213"/>
        <property type="gene ID" value="HS99_0033375"/>
    </dbReference>
    <dbReference type="OMA" id="QWFTAFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="43008" checksum="233C03D77DBBDCDF" modified="2017-01-18" version="1">MQHAPLPETVGVERLRAWWSHRQWLDRPHTGASAAEVLAATGWARSVGGAAPYLGLFARAGLGRAAVDAAVAGLQVHELPAARGCTYVLPAADFALGLAVGAAAPEGELAAAAKHLGVGRDEVEQLCLAVERVLSDGGPLDPTAIREAVGDAVRPLGEAGRKRGLSTTLPLALGLMQSRGRIRRVPVNGRLDQQRYGYVGWDQPVAGNAVDLARRYFSWAGPATLGHFRWFSGFTAATARRAVAEAGAVPLTPGSELLLLPELAEAFAEFEVPSEPHYTLLAGIDGIHLLHRDLSRLLDPADAARPLPAGRAGRTFGGEADPQTHLVLDRGRIVGLWEYDTERAEIVHQSFVPPDDALREAVARTEAFVRDELGDARGFSLDSPKSRAPKIAALRAAALARQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4E0</accession>
    <name>A0A1E7N4E0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ORF">HS99_0006430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597105.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5344"/>
    <dbReference type="EnsemblBacteria" id="OEV35558">
        <property type="protein sequence ID" value="OEV35558"/>
        <property type="gene ID" value="HS99_0006430"/>
    </dbReference>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="128"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="349"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="424"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="424"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="521" mass="53948" checksum="67E8DE5E52D0F86B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C4</accession>
    <name>A0A1E7N5C4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286218.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7272"/>
    <dbReference type="EnsemblBacteria" id="ARF81103">
        <property type="protein sequence ID" value="ARF81103"/>
        <property type="gene ID" value="B6264_21295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35892">
        <property type="protein sequence ID" value="OEV35892"/>
        <property type="gene ID" value="HS99_0008520"/>
    </dbReference>
    <dbReference type="OMA" id="KYRALDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="31391" checksum="8A1D586FE415E673" modified="2017-01-18" version="1">MSIKRSALSVGAVGAAVLAVAAATAGTAAAHGTMTGPVSRIAACYAEGPEHPVSQVCKDLVAAGGTQPLYDWNEVNIANANGNHQALIPDGRLCSANRDKYAALDWPRTDWPATPVSAGKFTFQFRTTAPHVGTQTVYITKPSYDPTKPLKWSDLDPTPVAQAQVDRTAVNGYYTYSGTLPQRTGRQLLYTVWQRSDSPEAFYSCSDVDFGAAGAAGAPAVSSLAAPAGPGDAQIAADAAKSTVAHHGHGGDANAPAGQPLPTSSAAVAGTSATGPLLLAGAAALGVGWAGMVLRRRRIEAVRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E5</accession>
    <name>A0A1E7N5E5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553623.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7293"/>
    <dbReference type="EnsemblBacteria" id="ARF81124">
        <property type="protein sequence ID" value="ARF81124"/>
        <property type="gene ID" value="B6264_21400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35912">
        <property type="protein sequence ID" value="OEV35912"/>
        <property type="gene ID" value="HS99_0008625"/>
    </dbReference>
    <dbReference type="OMA" id="LCITAHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032330">
        <property type="entry name" value="EF-G-binding_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16571">
        <property type="entry name" value="FBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="18018" checksum="0857B7CF3911F204" modified="2017-01-18" version="1">MEPLSDPEIRASFVNCSKGEAGRLNLPRGLAELPWESLDFLGWRDQGAPDRAYLVAPYGGELVGVTLRSPTVRRSLTKTNVCSLCITAHAGSGVALLAARRAGAAGREGNTVGTYICADLACSLYVRGLKKSTLVTRPDESMPLEDQIARTVLNLDAFLARVLTDTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5S5</accession>
    <name>A0A1E7N5S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6348"/>
    <dbReference type="EnsemblBacteria" id="ARF78775">
        <property type="protein sequence ID" value="ARF78775"/>
        <property type="gene ID" value="B6264_07455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36056">
        <property type="protein sequence ID" value="OEV36056"/>
        <property type="gene ID" value="HS99_0031670"/>
    </dbReference>
    <dbReference type="OMA" id="AMNINGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17006" checksum="52EBB9AD59EABF0E" modified="2017-01-18" version="1">MSKLHQRVIDGPFGPIQVSHDRWPSVVARVQGSGMPTVTVVPDRDHGAMNINGHNVPTTRKSRTRTAVVGDRSYELRSTSLRGAELRRNGTLIAHARGTFRSYAPGRTIPGLDAKVTWSQGIDPTDVAVGQAMVIAFGAGGPGAVLRTIFFWYDNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V5</accession>
    <name>A0A1E7N5V5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0031690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366581.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6352"/>
    <dbReference type="EnsemblBacteria" id="ARF78772">
        <property type="protein sequence ID" value="ARF78772"/>
        <property type="gene ID" value="B6264_07435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36059">
        <property type="protein sequence ID" value="OEV36059"/>
        <property type="gene ID" value="HS99_0031690"/>
    </dbReference>
    <dbReference type="OMA" id="GSASPFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="484" mass="52228" checksum="2D80E96CEF145E3E" modified="2017-01-18" version="1">MALPSALRGKSAVLAAAGIVVVAGTFALLDRGDRTGVSGPLRVPVSVGAPGRTLPPDVGRDLLARDPKASPNARAVDQFLTDLETQARTGQSGGTVIGQHVEAHNERNNPGYGDYRGTKQVGYYYKKAADITGRLPGFLETDLGPGYGQNAWGVGNPRSYSAGRWPTCRTGWQYTDDAVDLMTAVWSGHPRADDGTYDSSGVQQNCDGSSTDLPDNGGAPAGIVGMSFHEPYPGSDVKSFDRVLCSNSPAAKDPGWFGRVVDAADGTPEYRALITDLSYLADHLEYLAAHDVPVLLRPYHEMNVQDCSSRFWWAGQKPADYQALWKITYKYLVETRGLHNLLFVWTPVSWDGAPGVDPWDYYPGSQYVDVVGVDDYSGSPAHPIGTGEVWTKRYYDGLAAYDKPRMLAESFAVPVNSRQPDTLRRTPWTIWTVWGQSLTAGNLAPDQPRNSTADVNATYHSPLAITGGSGSSGGSIDWGGLHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X8</accession>
    <name>A0A1E7N5X8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0031045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4985"/>
    <dbReference type="EnsemblBacteria" id="OEV36107">
        <property type="protein sequence ID" value="OEV36107"/>
        <property type="gene ID" value="HS99_0031045"/>
    </dbReference>
    <dbReference type="OMA" id="RYSGPDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="34844" checksum="53424940BC426E35" modified="2017-01-18" version="1">MTMSTVAANAPGVAGSGLADVAASEASLRRFLHGLPGVDQVGLEARAATLGTRSIKTTAKAYAIDLAISMIDLTTLEGADTVGKVRALCAKGRTPDPTDPTTPRVAAICVYPDMVATAKDALRGTDIQVASVATAFPAGRAALPVKLADTADAVAAGADEIDMVIDRGAFLSGRYFDVYNEIVAVKEACKRPDGTYAHLKVIFETGELQTYDNVRRVSWLAMLAGADFIKTSTGKVAVNATPPVTLLMLEAVRDFRAATGVQVGVKPAGGIKTTKDAMKYLVMVNETLGDDWLSPHWFRFGASSLLNDLLMQRQKLATGRYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N624</accession>
    <name>A0A1E7N624_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80085">
        <property type="protein sequence ID" value="ARF80085"/>
        <property type="gene ID" value="B6264_15205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36140">
        <property type="protein sequence ID" value="OEV36140"/>
        <property type="gene ID" value="HS99_0031225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8339" checksum="8FCD15C95254A94F" modified="2017-01-18" version="1">MVPAIREPRCHRRERQPVPGRDDSFGHFGDPQARYPDQLSGQVARDVRPACEVAVQASELVVGDGGGEGVDAELEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N698</accession>
    <name>A0A1E7N698_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284355.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8109"/>
    <dbReference type="EnsemblBacteria" id="ARF79785">
        <property type="protein sequence ID" value="ARF79785"/>
        <property type="gene ID" value="B6264_13500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36174">
        <property type="protein sequence ID" value="OEV36174"/>
        <property type="gene ID" value="HS99_0030455"/>
    </dbReference>
    <dbReference type="OMA" id="WVLGDSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="44091" checksum="503D46130EF8D858" modified="2017-01-18" version="1">MHRLNAWLRRHPMVVDAAWASIVLFLGLLPDGSLPDTGWRHDSVILVAVLLPLLMVFRRRFPDVTVAAAAGVAVGQVAADVDPGGSSIAYLVFAYTGAAFGQKWTSRLALLAGLAAGPLVFWRMHLVKTSTDHTGIYVSRPYGLGEAVLITLLMSTPFILCWAWGRLTRVRRAYLTELEDRAARLERERDAQSKVAVAAERARIARELHDVVAHNVSVMIVQADGAAYVLDNSPAQAKEALGTIASTGRQALVEMRRLLGVLRTADTAEEYVPQPGVEELPDLLEQVRTAGLAVDYATSGHPRELPRGVELTVYRIVQEALTNVRKHGGPDAHARVAVDFGERELAVLVEDDGRGSTDEQLTAGGADGLGHGLIGMRERVGMVSGSLDVGPRPGGGFRIRAVLPLKAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H1</accession>
    <name>A0A1E7N6H1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387566.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000349.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2641"/>
    <dbReference type="EnsemblBacteria" id="OEV36279">
        <property type="protein sequence ID" value="OEV36279"/>
        <property type="gene ID" value="HS99_0030185"/>
    </dbReference>
    <dbReference type="OMA" id="AFFGHCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="27463" checksum="1F5E5580FB60302B" modified="2017-01-18" version="1">MQTDAGKWLFRQPSEDAPARIFLFPYSGTGASMYRAWPERIGEVEVCLVQLPARENRLREPHPVTYQNLAAAAAAALAPLVDRPTGFFGHCGGALSAFATALELERAHGKELTALFMSSQLAPDEEPFGRWLWLGRDELAVELNILAQAAGTRMDPDFLDVALDVLEEDLAAQRRYRLDAPEPLACAVHTVGWKQDVEIRPEQLGGWTRYVPPGRHHEHLLDGGHHAFLAAPQPLLDLMGRAMAQAGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I1</accession>
    <name>A0A1E7N6I1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythronolide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550846.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2617"/>
    <dbReference type="EnsemblBacteria" id="OEV36300">
        <property type="protein sequence ID" value="OEV36300"/>
        <property type="gene ID" value="HS99_0030300"/>
    </dbReference>
    <dbReference type="OMA" id="FHYAVHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="593" mass="63495" checksum="DEC1CB0A70980925" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M6</accession>
    <name>A0A1E7N6M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835526.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000502.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N6M6"/>
    <dbReference type="STRING" id="1894.JOER01000017_gene4887"/>
    <dbReference type="EnsemblBacteria" id="ARF82381">
        <property type="protein sequence ID" value="ARF82381"/>
        <property type="gene ID" value="B6264_29030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36329">
        <property type="protein sequence ID" value="OEV36329"/>
        <property type="gene ID" value="HS99_0029630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="817" mass="89296" checksum="1693F4705EE829A4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6U2</accession>
    <name>A0A1E7N6U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7161"/>
    <dbReference type="EnsemblBacteria" id="ARF83133">
        <property type="protein sequence ID" value="ARF83133"/>
        <property type="gene ID" value="B6264_28910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36410">
        <property type="protein sequence ID" value="OEV36410"/>
        <property type="gene ID" value="HS99_0029745"/>
    </dbReference>
    <dbReference type="OMA" id="PLNLQGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="38580" checksum="6DBDF476E684D74B" modified="2017-01-18" version="1">MAAVVLATAGTALDGCQRGLSTRAGAPVAGPSRAGCPPATLARAKAGVQQAEQVDVPWDGPTSGPRAVPGRTIVYVAQTMTNPGVVGVAKGVIEAATVIGWSVRVIDGQGTPAGIQAALAQAVNLEPSGIVIGGFDPGLTAQQVAQADTAHIPLIGWHAVAAPGPSTSPPLFSNITTSVGDVARLSADWVIAESDGRAGVVVFTDDSVPFARNKSELIKDELATCPGVRLLASENIPIPDATSRTPQAVSALLARFQGQWTHSVAINDLYFADAAPALRAAGRPGNAAPYNIGAGDGDPSAFQRIDSRQFQAATVPEPLSEQGWQIVDEFNRAFSHQPASGYVAPVHISTAANSGGATFWDPGGYRQAYRTIWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W6</accession>
    <name>A0A1E7N6W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfonate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554232.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene212"/>
    <dbReference type="EnsemblBacteria" id="ARF82248">
        <property type="protein sequence ID" value="ARF82248"/>
        <property type="gene ID" value="B6264_28235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36447">
        <property type="protein sequence ID" value="OEV36447"/>
        <property type="gene ID" value="HS99_0029370"/>
    </dbReference>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="579" mass="62791" checksum="B9068D7EE74B40E2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Z1</accession>
    <name>A0A1E7N6Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554206.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene196"/>
    <dbReference type="EnsemblBacteria" id="OEV36460">
        <property type="protein sequence ID" value="OEV36460"/>
        <property type="gene ID" value="HS99_0029445"/>
    </dbReference>
    <dbReference type="OMA" id="PDFRAWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="43855" checksum="B9C5E58F2A1E4610" modified="2017-01-18" version="1">MTPLDPTVKSLLIDPYGTYAELRAEAPVQRIVGPDGLPVWLVTRYPDVRQALADPRLALDRAHAAPGNYRGFALPPALDANLLNMDPPDHTRIRRLVAQAFTPRRMAALRAPIERVAEQLLDAVEDTAGPSRRVDLLARYAAPLPITVICDLLGVPEDDRHDFRAWTDTLITPDPDRPEQARDAVRAMLAFFTGLIGRKRAEPADDLLSDLIAVRDEQDRLSEEELTSLAFLILFAGYENTVHLIANAVLALLTHPEQLATLRAEPELVAGAVEEFARFDGPAPLAIRRFPREDVTIGGVTVPAGETVLLSLASANRDPEQFGEPDRLDLRRRESGHLALGHGIHYCLGAPLARMETALAITALLRRFPALALGVPAEQLRHRPTMRARGLLELPVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N711</accession>
    <name>A0A1E7N711_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554245.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene226"/>
    <dbReference type="EnsemblBacteria" id="ARF83122">
        <property type="protein sequence ID" value="ARF83122"/>
        <property type="gene ID" value="B6264_28305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36480">
        <property type="protein sequence ID" value="OEV36480"/>
        <property type="gene ID" value="HS99_0029310"/>
    </dbReference>
    <dbReference type="OMA" id="SGVYKET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14980" checksum="10C1360988F786C9" modified="2017-01-18" version="1">MAGFAESPAPADVVRRQYLASARGDLAALRSTLAEDVEWTEMAGFPLAGTYRTPKGVIAHVMERLAAEWDHWTAHDDTYVVDGENVVVLGRYTAVHRDTGKPLSVRVAHHFTVRGGRIVRFEQFTDTALVRDATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N716</accession>
    <name>A0A1E7N716_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8063"/>
    <dbReference type="EnsemblBacteria" id="ARF82822">
        <property type="protein sequence ID" value="ARF82822"/>
        <property type="gene ID" value="B6264_13740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36253">
        <property type="protein sequence ID" value="OEV36253"/>
        <property type="gene ID" value="HS99_0030685"/>
    </dbReference>
    <dbReference type="OMA" id="DPRKRQC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="24032" checksum="2D21A400FE245FD3" modified="2017-01-18" version="1">MRHGEVHNPEGVLYGRLPDYHLSELGRQMADRVAEDLADRDITHVVASPLERAQETAAPIAKAHGLDLAVDERLIEAENVFEGKTFGVGDGSLRNPGYWKYLTNPFKPSWGEPYLDQAVRMMGALGAARDAARGHEAVCVSHQLPIWILRSFVERRRLWHDPRNRQCSLASLTSFTFEGDRIVSVGYREPARDLLPAHLVGKGRKGDKPVGKSFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N777</accession>
    <name>A0A1E7N777_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289665.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7883"/>
    <dbReference type="EnsemblBacteria" id="ARF79145">
        <property type="protein sequence ID" value="ARF79145"/>
        <property type="gene ID" value="B6264_09635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36551">
        <property type="protein sequence ID" value="OEV36551"/>
        <property type="gene ID" value="HS99_0028950"/>
    </dbReference>
    <dbReference type="OMA" id="IWQKERG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7357" checksum="6D617B24540F8A68" modified="2017-01-18" version="1">MAQGTVKWFNAEKGYGFIAVDGGADVFVHYSAIQMDGYRTLEEGQRVEFEISQGQKGPQADMVRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F4</accession>
    <name>A0A1E7N7F4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1458"/>
    <dbReference type="EnsemblBacteria" id="ARF82732">
        <property type="protein sequence ID" value="ARF82732"/>
        <property type="gene ID" value="B6264_09820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36598">
        <property type="protein sequence ID" value="OEV36598"/>
        <property type="gene ID" value="HS99_0028760"/>
    </dbReference>
    <dbReference type="OMA" id="RHHELGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="4">
        <location>
            <begin position="243"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="34372" checksum="B145BDCC9050B533" modified="2017-01-18" version="1">MKSPLLALPGAVPAEGADEGVAAHYGDIFREQRNLSQGTGFVDLSHRGVVTVTGADRLSWLHLLLTQHVSQLEPQHATEALVLSPNGHVEHALYLVDDGTTTWAHVEPGTQGALVAYLESMKFFYRVEVADATADYAVVHLPAGSTGSVDGAAAVRELPYGRDLFVPRAGLEGVTAGFGPAAGVWAYEALRIEGHRPRLGFETDHRTIPHEVDWLSTAVHLQKGCYRGQETVARVHNLGRPPRRLVFLHLDGTEETLPPHGTEVRLASDPDGRSLGFVTSSARHHELGPIALAIVKRNVPVDAVLLAGTVPGTQDVIVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L4</accession>
    <name>A0A1E7N7L4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2494"/>
    <dbReference type="EnsemblBacteria" id="ARF81507">
        <property type="protein sequence ID" value="ARF81507"/>
        <property type="gene ID" value="B6264_23645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36680">
        <property type="protein sequence ID" value="OEV36680"/>
        <property type="gene ID" value="HS99_0028360"/>
    </dbReference>
    <dbReference type="OMA" id="IHWTFLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15208" checksum="E01E2CB1D8F78C26" modified="2017-01-18" version="1">MNDITIHWTFLPHTDPEASLAFYRDLLGFEVRQDVGGGPMRWITVGPADQPGVSLVLEPPFADPGITEDERRTITEMMAKGTYARLVLATADLDGVFDRLKSGGAELVQEPTLQPYGIRDCAFRDPAGNMVRFNEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V4</accession>
    <name>A0A1E7N7V4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0028900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366637.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1431"/>
    <dbReference type="EnsemblBacteria" id="ARF79154">
        <property type="protein sequence ID" value="ARF79154"/>
        <property type="gene ID" value="B6264_09685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36543">
        <property type="protein sequence ID" value="OEV36543"/>
        <property type="gene ID" value="HS99_0028900"/>
    </dbReference>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="40518" checksum="E389991DE39A94B9" modified="2017-01-18" version="1">MTTADRDRTALAGARLVLPGGVVEGDRLAVEGSRIAAITSGGTEPGDLDLTGHTVVPGFVDLHVHGGGGASYASGIAEEALLAARTHLEHGTTTTMASTVTGEIDDVARQAAVLSELVEDGILAGVHFEGPFISHNRCGAHRPDLLRDPDPALVRKLVDAARGHARMVTLAPELPGGLDSVRMLADLGVIAAVGHTDSDYPTTLEAIDAGATVATHLFNAMPGIAHRAPGPIVALLEDERVTVELINDGVHLHPSVLDLAYGTAGPGRVALITDAMGAAGMGDGLYPLGPLQVRVESGVARLVEGGAIAGSTLTLDVAFKRSVTVNGLTLDQTVESLCTTPARLLGLTDSVGSLETGKLADLVVVDSTSYDLVAVMHRGRWVLGGDRFPIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8B6</accession>
    <name>A0A1E7N8B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2545"/>
    <dbReference type="EnsemblBacteria" id="OEV36713">
        <property type="protein sequence ID" value="OEV36713"/>
        <property type="gene ID" value="HS99_0028115"/>
    </dbReference>
    <dbReference type="OMA" id="RAGMSKQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="15405" checksum="E245185E761DF074" modified="2017-01-18" version="1">MTDRFHALLAERGREPLRPAHGYTFRYLASHPHATTVDLAAHLGVTKQATSKAVAELEDWGYVERRPHTTDKRAQVLALTTRGREYLELADELWTTVEGQLADVIGTERLAALDRDLRTYIAAVHADQEVSFRPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E5</accession>
    <name>A0A1E7N8E5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552956.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4764"/>
    <dbReference type="EnsemblBacteria" id="OEV36743">
        <property type="protein sequence ID" value="OEV36743"/>
        <property type="gene ID" value="HS99_0027380"/>
    </dbReference>
    <dbReference type="OMA" id="LCHAFYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="21084" checksum="66C979C3A18E2AC2" modified="2017-01-18" version="1">MTPADHRSPSTPAWSHVEEFLRAHDADRIPHPGGTLLEHLTRVAALLAEWGTDSAVQAAGLCHAAYSTDGFDGALLALDERGTLVDVVGERAEALVYLYASCGRTAVYPRLGRDEVPLFHDRFTGRDHTPPEEDLRAFLAITAANELDVFTHNAELADRYGPVLYELLSRNRELLPAAAWQAWHDKYGQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z1</accession>
    <name>A0A1E7N8Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555715.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6653"/>
    <dbReference type="EnsemblBacteria" id="ARF81604">
        <property type="protein sequence ID" value="ARF81604"/>
        <property type="gene ID" value="B6264_24260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37128">
        <property type="protein sequence ID" value="OEV37128"/>
        <property type="gene ID" value="HS99_0004735"/>
    </dbReference>
    <dbReference type="OMA" id="CAEYKIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20599" checksum="1F001B75C88D86F4" modified="2017-01-18" version="1">MDSLKLLAHPIRLRIVHAMGGGRLLTTAQLCARIPEASKATVYRHIDLLVNGGILEVAEEHRVRGAVERHYRLCQDRAAVGAGVVRTLTPEDHRQAFATAMTALLAEFNAYLDREEADPVADQVGYRQHALWLSPAELAELIGELRTAIVPRLANSPGPERAQYLLSPIHFPVEAPQQPAGRPATGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N975</accession>
    <name>A0A1E7N975_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1325"/>
    <dbReference type="EnsemblBacteria" id="OEV37245">
        <property type="protein sequence ID" value="OEV37245"/>
        <property type="gene ID" value="HS99_0005440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="9979" checksum="4FDD39F7618B3F33" modified="2017-01-18" version="1">MVHHGGNNSFTECLHAGVPALVLPFSSDQFAIAHDAERAAAGRCLDPNTLTPAAAGHAVAALLADRAHGTAALGVRLRPHGPARAASALLRCMPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A5</accession>
    <name>A0A1E7N9A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1288"/>
    <dbReference type="EnsemblBacteria" id="OEV37277">
        <property type="protein sequence ID" value="OEV37277"/>
        <property type="gene ID" value="HS99_0005635"/>
    </dbReference>
    <dbReference type="OMA" id="HRTELIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="19911" checksum="2D0DB32F22EA05A2" modified="2017-01-18" version="1">MEATIEDLKALGHPLRWRILRLCLDRALTNKELSVELDLAPATTLRHVRALVKTDFLVAEPVSTGEHGALQRPYRATARTRGLIITPDDSGLAQQVDLAVLGAHRTELIAAGKDSGRGANRGVLRLRPESVESLRRRIQDLIAEYPDEPDGEPLSYLWSLAARPQPDPDSRESAEDPIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H7</accession>
    <name>A0A1E7N9H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0006060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556469.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5445"/>
    <dbReference type="EnsemblBacteria" id="OEV37347">
        <property type="protein sequence ID" value="OEV37347"/>
        <property type="gene ID" value="HS99_0006060"/>
    </dbReference>
    <dbReference type="OMA" id="RWFTPCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="29332" checksum="4F5599352E2DB9C0" modified="2017-01-18" version="1">MSWSVGQVSGFAGVTVRTLHHYDRSGLLSPSERSPAGYRLYNAADLARLQQILFYRELGFPLEEIATILADPLANALDHLLARRDALTEQIARLQKLVDVAERAIEVQRTGIELTPEERFEVFGDVVFDLSYAADAHLKWGNQQGHQEALARAANHTKEDWRRLMAEAADWRGRLLAAFDQGLPADGEEALDLAEEHRQHITRWFTPCPPETHCRIADDYEADARAFALVVPPAEQRPGLAGYLRAAIGANAEQRAATGSEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M6</accession>
    <name>A0A1E7N9M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82509">
        <property type="protein sequence ID" value="ARF82509"/>
        <property type="gene ID" value="B6264_29825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37395">
        <property type="protein sequence ID" value="OEV37395"/>
        <property type="gene ID" value="HS99_0006350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="7675" checksum="82E45AE606A54B3C" modified="2017-01-18" version="1">MVVVGEGVDAGAVEGGVEGLGCGAGEAAVGEVGGLSGLVGGLAGTVGDVLPVVLTAQRVLEGGVVVGVVALGACWRAVSWSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P9</accession>
    <name>A0A1E7N9P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0004435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7421"/>
    <dbReference type="EnsemblBacteria" id="OEV37420">
        <property type="protein sequence ID" value="OEV37420"/>
        <property type="gene ID" value="HS99_0004435"/>
    </dbReference>
    <dbReference type="OMA" id="FAFWRRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="500" mass="55280" checksum="7EE459B7038D5D59" modified="2017-01-18" version="1">MPSVRAQAGPVSQAGSKAVRQEGRQEGRDGRQEGAQASQHGLLPDSLSDRGNAKLFVHLYGRDYRHVPGIGWYRWATHRWQLDEDDTVLWAAGEMAESIATHDARGLYTNTDLRRHRRRALSTSGMNAMLAQAKSAPGMVLNAALLDADAYALCTPGGVVDLRTGAIVPPDPKVHHHSRSTTLAPARMPTPRWDRFLTDTFGDDKEGRQTRDFLHLLLGYSISGDVGAQVMPFLYGQGKNGKSVLLDVMIQLLGDYADAAPPGFLMAKTFDGHPTDLAELHGRRIIVCSELKPGDRFDEARVKLLTGGDKIKARRMRQDFFSFEPTHKLWLLGNHRPEVGTGGFAFWRRMRLIPFERVVPEERKIDNLAHVLVAEEGPGILAWLIDGARRYFAGEKDLAGPQAVQTATTAYAETEDHVGRFLKEACVTGEGMRAEQSQLFGAYTRWCGFEGANPVSGRAFAARVRETLGMTSPKEMVLSNSRKYYPGIGLITDDTEEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R5</accession>
    <name>A0A1E7N9R5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6156"/>
    <dbReference type="EnsemblBacteria" id="OEV37435">
        <property type="protein sequence ID" value="OEV37435"/>
        <property type="gene ID" value="HS99_0005205"/>
    </dbReference>
    <dbReference type="OMA" id="ARPSPQN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="26887" checksum="41AA3316114B0975" modified="2017-01-18" version="1">MNGDRDAIRLSLGGYVLGTLSPAEAEQVRAHLAECAECRAEHAELAGLPALLARVSEAEAEAAGEAPPAPSGELADRLVQRAAARERAQPEPPPAATAAAGVQQQTGQSRLDRLLQQAASRRRTAVRRQLVGVTAAATIVAAAASGGTWLATVATTSSQVAQPAPTSPAPVRTFSGTDPTTGVSASIKVSPAAWGSALQVSARGAPAGITCSLQAVGITGSTATAATWQAGDYPGGAAISGTVPMSPGMISHFDIYAGNGQRLLTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC3</accession>
    <name>A0A1E7NAC3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280718.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1706"/>
    <dbReference type="EnsemblBacteria" id="ARF79907">
        <property type="protein sequence ID" value="ARF79907"/>
        <property type="gene ID" value="B6264_14225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37650">
        <property type="protein sequence ID" value="OEV37650"/>
        <property type="gene ID" value="HS99_0025440"/>
    </dbReference>
    <dbReference type="OMA" id="QEMISTC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="45059" checksum="64E0BB029399F755" modified="2017-01-18" version="1">MTTTAKFDPWSAAFVAHPYDVYAELREHAPVTYHEPTNQWLVSRHEDVSALLRDRRLGRTYTHRFSHQEFGRPEPDPAHEPFHTLNDHGLLDLEAPDHTRIRRLVSKAFTPRMVEGLRPTVQRLAGELVDGLLAAGGGDLIAAVAEPLPVAVIAEMLGVPEGDRHLLRPWSADITGMFELNPSEEVARRAVTASTEFSDYLRALIRERRANPGEDLISALIQAQEGSDALSEQEMVSTCVLLLNAGHEATVNTTGNGWWALFRNPGELARLRGDVDGLLPTAVEELMRWDTPLQMFERWVLEDIEVRGVTVPRGAEIALLFGSANRDPERFADPDRLDLGRTDNPHITFGAGIHFCLGAPLARLELTESFGALLRRAPGLRLVREPEWNPGYVIRGLKELLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC7</accession>
    <name>A0A1E7NAC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8007"/>
    <dbReference type="EnsemblBacteria" id="ARF79871">
        <property type="protein sequence ID" value="ARF79871"/>
        <property type="gene ID" value="B6264_14020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37618">
        <property type="protein sequence ID" value="OEV37618"/>
        <property type="gene ID" value="HS99_0025235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7614" checksum="F0D9106C7BEF47C5" modified="2017-01-18" version="1">MASGAVTRRRSVLVVPVTAITRLTVLIPEVEPAHWWQCARQNRSGAVIDRALRRHADAVVRRLRMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK5</accession>
    <name>A0A1E7NAK5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0025890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737872.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4918"/>
    <dbReference type="EnsemblBacteria" id="OEV37730">
        <property type="protein sequence ID" value="OEV37730"/>
        <property type="gene ID" value="HS99_0025890"/>
    </dbReference>
    <dbReference type="OMA" id="CTHSGCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="244"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="35237" checksum="43D6A85791BE2BCF" modified="2017-01-18" version="1">MSEVSSSEAVGGEAADRAVRAERWRALASRHALLPLRLFLGITFVYAALDKLSDAHFLAGAGDQASFVSQTRAAKDGGSPIAFLLGPALDHPTLSALAIAFGELAVGLGTLLGLWGRVAALGGALINLSLWLTVSWNVSPYYLGNDLGYLMAWTPLLLAGTPDLSVDGYLARRAGRDRERGLAEDHVKRRALVDGGIAAVAIGGAGLLTGSLTRTFGWGRQAAAPVQSAPVPSAAPVPSGTAPAPTVAAASVPVGGSAQVKDPATGDAVYIVQPKAGQYCAFSSVCTHSGCAVDAPKNGQFYCPCHGSRFDAATGAVVNGPAVKPLPRYGVGKDGDKLTLGPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL3</accession>
    <name>A0A1E7NAL3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0025750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280827.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1644"/>
    <dbReference type="EnsemblBacteria" id="ARF79965">
        <property type="protein sequence ID" value="ARF79965"/>
        <property type="gene ID" value="B6264_14540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37708">
        <property type="protein sequence ID" value="OEV37708"/>
        <property type="gene ID" value="HS99_0025750"/>
    </dbReference>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="41934" checksum="24CA0035EBF57605" modified="2017-01-18" version="1">MTTANTTGTATLTDGVRAEATIDLAALRGNLAALQERVGSTAVMLAVKADAYGHGAVECAREAVANGVGWLGCATPDEALALRAAGIRPEQARILCWLWTPGGPWREALRADLDISVSGRWALEELLTAVRETGIPARVHLKADTGLGRNGCQPHDWPQLVAEVRRAEAAGLLKAVGIWSHFAAADEPGHPSIQAQLDSYRAALAHAELAGLRPEVRHLANSPATLLLPETHFDLVRTGLAAYGLSPVPEVGSPADFGLRPVMALTARLALVKHVPGGHGVSYGHHYVTPGPTTLGLVPVGYGDGVPRHASGTGPVQIDGKWRTVAGRVAMDQFVVDLGGDTPEAGDEVLLFGNGERGEPTAEDWARASGSISYEIITRIGARVPRRYLGGSHDGSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT3</accession>
    <name>A0A1E7NAT3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0024770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557071.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3753"/>
    <dbReference type="EnsemblBacteria" id="ARF78059">
        <property type="protein sequence ID" value="ARF78059"/>
        <property type="gene ID" value="B6264_03220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37806">
        <property type="protein sequence ID" value="OEV37806"/>
        <property type="gene ID" value="HS99_0024770"/>
    </dbReference>
    <dbReference type="OMA" id="DWVMIAS"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV37806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="369" mass="41239" checksum="8AF88F5D38EA6EB9" modified="2017-01-18" version="1">MHKTATKLADGRELFYYDQEPTAVRDDTVDERPLEPAASLSEIRLDPVLGEWVTVAAHRQQRTYHPPAGECPLCPSREGRLSEVPAADYEVVVFENRFPSLAPDSAAHVAAHDDDPLRTLRPGNGRCEVVCFAPDHDASFADLDEPGARLVLDAWTDRTAELSALPDVRQVYCFENRGEEIGVTLAHPHGQIYAFPFVPSRTARMINRAQAHRANTGRNLFEDLLAAERATPERLVLQGEHWTAFVPFAARWPYEVHLYPNRRVRDLTALDEAERDEFPGLYLDLLRRFDRLFPAPDGAAPNRTPYISAWHQAPKDGGDELALHLELFTIRRAPGKLKYLAGVESGLDAFVTDVSPEAAAERLRAAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU0</accession>
    <name>A0A1E7NAU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558025.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000965.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3451"/>
    <dbReference type="EnsemblBacteria" id="ARF78100">
        <property type="protein sequence ID" value="ARF78100"/>
        <property type="gene ID" value="B6264_03475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37764">
        <property type="protein sequence ID" value="OEV37764"/>
        <property type="gene ID" value="HS99_0024525"/>
    </dbReference>
    <dbReference type="OMA" id="CAFADHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012467">
        <property type="entry name" value="DUF1684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41913">
        <property type="entry name" value="PTHR41913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07920">
        <property type="entry name" value="DUF1684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27950" checksum="4B870D13179DFE5A" modified="2017-01-18" version="1">MTATAAEDWKHWSDRRAASVSAPHGQLALTGTHWLEPEPVEIPGLPGRWWADAEGVRVRAAAADGITVGGADGPVDGEVLLRPDTDPAADTATVGELLLVPIEREGELALRVFDPASPGRTGFAGISAYPYAPEWAVPAVYTPFEEEGQSVLVPNADGKDRPLAVTGTIEFTVAGEHRTLTVSRAGQRLTGVIADATSGIDTYRFRFITLPAPDGDGRTVLDFNRAYLPPCAFADHFICPFPPPGNRLDFAVEAGEKQVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU6</accession>
    <name>A0A1E7NAU6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557059.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3746"/>
    <dbReference type="EnsemblBacteria" id="ARF78054">
        <property type="protein sequence ID" value="ARF78054"/>
        <property type="gene ID" value="B6264_03190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37811">
        <property type="protein sequence ID" value="OEV37811"/>
        <property type="gene ID" value="HS99_0024800"/>
    </dbReference>
    <dbReference type="OMA" id="VSFGMIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="34539" checksum="12474E611CF09365" modified="2017-01-18" version="1">MSTSHTSTTSSQSRSRSRPRPAARADRSRHGAVGFAFFAPFLVVFVIGIAAPLGYAAYLSFFQDRMIGGNVFVGFDNYRRALGDELFRAGLWRVLLFLLVQVPVMLGLALVAALAVDSGRLRKPGLFRIGIFVPYAVPAVVASLMWGYLYGDRFGLVGQIGDLLHVDMPDFLGSSWMLASIGNVVTWEYVGYNMLILYAALRTVPHELYEAAEMDGAGEFRKAWSIKLPAVRSALVLATVFSIIGTFQLFNEPNVMQSLAPGVISTSYTPNMYAYNLAFNGQQFNYSAAVAVVLGGVTAIVAYAVQIRSMRKEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB22</accession>
    <name>A0A1E7NB22_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polynucleotide adenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5989"/>
    <dbReference type="EnsemblBacteria" id="OEV37879">
        <property type="protein sequence ID" value="OEV37879"/>
        <property type="gene ID" value="HS99_0025130"/>
    </dbReference>
    <dbReference type="OMA" id="IRWEHDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21433" checksum="2AD055CEC0C48514" modified="2017-01-18" version="1">MLDLPPTARTAVAWLPPAELWPAIQAVREVHDRQIRRWPPHVNVLFGFVPEDAFPAAAPLLAEAAAEIRPFAARLSGVHSFRHRHDSTVWLDPAATGTGPWVRLHRAFSARFPHCRTHGDRFTPHLSLGRTRDPRHLAPDLAARLGSTTARVDELSLLSRRAGGPMCVRATVALGTGTVHWLPHPDADPPWPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD6</accession>
    <name>A0A1E7NBD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2038"/>
    <dbReference type="EnsemblBacteria" id="ARF79523">
        <property type="protein sequence ID" value="ARF79523"/>
        <property type="gene ID" value="B6264_11885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37968">
        <property type="protein sequence ID" value="OEV37968"/>
        <property type="gene ID" value="HS99_0024210"/>
    </dbReference>
    <dbReference type="OMA" id="HARRTMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="35819" checksum="0201260A4C7932A7" modified="2017-01-18" version="1">MSAELVRQALQDPALLARSVPGLSTEPAAVGAGPAEEIGGRLKLRIGGSTITFKGVLSLIEGRNGVLTVLAEGQEARGSGEATATVRVSVTDGTEDGTAAVRFTGDLSATGRLAEFDAETLDAAGRRLLDRFATALTSPDAPDALDAPEEGDEELTDGTGDEGPDDAAAETGTDAEIVFIEELQDQPGDDLDDDLSDLIAFSDADAERFGLPTGSSDDDADEEDDVDDHDDSADAAGNAGDGPQDGVAEELPAEPLFAYEDEPELTGPVRRSIVGRSAEEVDHAPPRGRYAPALPARSARARAASRWGGEAGGIVVPGTGGRSAVPWVIGGSVALLGGAVVLVRALRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU1</accession>
    <name>A0A1E7NBU1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="1">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="1">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mshB</name>
        <name evidence="2" type="ORF">HS99_0023515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MshB deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287381.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene457"/>
    <dbReference type="EnsemblBacteria" id="ARF78856">
        <property type="protein sequence ID" value="ARF78856"/>
        <property type="gene ID" value="B6264_07940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38160">
        <property type="protein sequence ID" value="OEV38160"/>
        <property type="gene ID" value="HS99_0023515"/>
    </dbReference>
    <dbReference type="OMA" id="YWNRVPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32100" checksum="437E90991F8A8E3D" modified="2017-01-18" version="1">MTATTGRRLLLVHAHPDDESIGNGATMARYAAEGARVTLVTCTLGEGGEVIQPELAHLTADRDDTLGAHRIGELTEAMRALGVTDFRFLGGPGRYRDSGMMGVPDNDAPGCFWQADVDEAADHLVAVVREVRPQVLVTYDENGGYGHPDHIQAHRVAMRAYELAADPAHRPELGAPWRIAKVYWNRMPRSVLDAGLAATAAEAAFPGTAQPADVPGVVADEVVTTVLDGTAHAGRKAAAMAAHATQITVNGSSFALSNHLGQPLFATEYYQLVHGQAGPGRPERDLFAGLDTTAPTPSEGNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX9</accession>
    <name>A0A1E7NBX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4442 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290018.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3290"/>
    <dbReference type="EnsemblBacteria" id="ARF80290">
        <property type="protein sequence ID" value="ARF80290"/>
        <property type="gene ID" value="B6264_16465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38201">
        <property type="protein sequence ID" value="OEV38201"/>
        <property type="gene ID" value="HS99_0021815"/>
    </dbReference>
    <dbReference type="OMA" id="VWTLRPN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15569" checksum="5624160129798D59" modified="2017-01-18" version="1">MTTPSIGQMLDATVPMAHTLKLEYLETTPERAVLRLPDQPAYHNHVGGPHAGAMFTLAESASGCIVLAAFGDQLSRAVPLAVNAEIAYKKLAMGEVTATAVLGRPATEVVAELDAGGRPEFPVTVEITRTDGAVTGVMTVTWTLRPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBZ0</accession>
    <name>A0A1E7NBZ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0021915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598351.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3308"/>
    <dbReference type="EnsemblBacteria" id="OEV38216">
        <property type="protein sequence ID" value="OEV38216"/>
        <property type="gene ID" value="HS99_0021915"/>
    </dbReference>
    <dbReference type="OMA" id="NIDRRWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="40308" checksum="C3A2FA7993AC3760" modified="2017-01-18" version="1">MVPMATTQLTTTVSPKALPLPALLALATAVFVTALTETLPAGVLPGMSDALGVGESATGQAVTVYAIGTAATAIPLTAATAGWGRKRLLLTAMAGFALANTVTAASTSYPLTLAARFLAGVAAGLAWALLAGYARRLVPVDQQGRAMAVAMAGVPVALSLGVPIGTFLGQVLAWWVPFLAMTALALGVIGWIAALLPEQSGRPGGGRAPVRSALGVPGVVPVLAVTVLFVLAHTILFTYVTPFLARAGLGGSADSVLLVFGLASLAGVWLVGAHIHRRLRQLTIGGALLVAVTATLLGLGSHSAPLVYPAALLWGLGWGGVPTLLQTAVSDAGGERADAAQAMLVTLWNAAMAGGGLVGGLVLGRLGTGALPWTVLALLLSVLALTLAARRHGFPAVRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC90</accession>
    <name>A0A1E7NC90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4181"/>
    <dbReference type="EnsemblBacteria" id="ARF80185">
        <property type="protein sequence ID" value="ARF80185"/>
        <property type="gene ID" value="B6264_15830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38297">
        <property type="protein sequence ID" value="OEV38297"/>
        <property type="gene ID" value="HS99_0022440"/>
    </dbReference>
    <dbReference type="OMA" id="WDQDATA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="21081" checksum="938DE3B1285F779A" modified="2017-01-18" version="1">MSTSENHASPADAIVPDTKDWTWVLERPCPECGLDTPAVAATAVAGMVRDNARSWLAVLAGDEDGLRRRRSPEVWSDLEYACHVRDVFRLFLVRLDLMLDQDGPLFPNWDQDETAAAERYWEQRPQVVAGELAEAGEALAAAFEAVSGEQWRRTGDRSDGARFTVESFARYLIHDPVHHLFDVTGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN0</accession>
    <name>A0A1E7NCN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287764.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000832.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene325"/>
    <dbReference type="EnsemblBacteria" id="ARF82155">
        <property type="protein sequence ID" value="ARF82155"/>
        <property type="gene ID" value="B6264_27705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38449">
        <property type="protein sequence ID" value="OEV38449"/>
        <property type="gene ID" value="HS99_0021345"/>
    </dbReference>
    <dbReference type="OMA" id="EIDGCIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="13044" checksum="7D1870924DE6EF19" modified="2017-01-18" version="1">MTDAAGALKQAMTSIEGAIGAALVDYNSGMALATLDGPGGLDLNVAAAGNTDVVRAKMRTMDMLGLQDGIEDILITLTSQYHLIRPLGGRTGKGLFLYLALDKSRANLAMARHQLTRVEADLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN1</accession>
    <name>A0A1E7NCN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287771.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000814.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene328"/>
    <dbReference type="EnsemblBacteria" id="ARF82153">
        <property type="protein sequence ID" value="ARF82153"/>
        <property type="gene ID" value="B6264_27690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38452">
        <property type="protein sequence ID" value="OEV38452"/>
        <property type="gene ID" value="HS99_0021360"/>
    </dbReference>
    <dbReference type="OMA" id="GGDHETT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13533" checksum="B715EF37EE012896" modified="2017-01-18" version="1">MPGIDECLSGAMAIAGARSASLVDWSSGLALGSLGDSPVGEHETAAAETTDLVRAAVESQTFTVAEDRHSPLEDIIVTAGRSYHLIRFIDTAFDSRLVLHLWLDRQSGNLAVARFRLQALAEDLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU6</accession>
    <name>A0A1E7NCU6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554555.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82130">
        <property type="protein sequence ID" value="ARF82130"/>
        <property type="gene ID" value="B6264_27550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38474">
        <property type="protein sequence ID" value="OEV38474"/>
        <property type="gene ID" value="HS99_0021495"/>
    </dbReference>
    <dbReference type="OMA" id="WSFFGPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15902" checksum="978DC4822EEAB7C1" modified="2017-01-18" version="1">MRLVHLLRGLTVELDLFGAEFAARSGLHPTDLRALIHLLDAARAGEVVTPGRLGEALRLNSAGTTGLVDRLERLGLIRRERDPEDRRRIRLMVEERAMELGQGFFGGLIGDLVAAMDRFDAAELATARRFLEAMTSVVAAARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD3</accession>
    <name>A0A1E7NDD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene673"/>
    <dbReference type="EnsemblBacteria" id="OEV38700">
        <property type="protein sequence ID" value="OEV38700"/>
        <property type="gene ID" value="HS99_0020020"/>
    </dbReference>
    <dbReference type="OMA" id="IMREWGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="117"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="36950" checksum="84693D2546886DF0" modified="2017-01-18" version="1">MDGGTPSERIAAELRRRIAAGELKPGARVPSTRRIMREWGVAMATATKVLNRLREDGLVRAVPGVGTVVAARRAPAGAPAQGRAVAGREAGREVGREAERVPGAAGVVQRAKGGERELGRERIVEAAVRVADHEGLAALSMRRVATELGVATMSLYRHVPGKDELLRLMTDRVFGEQPLAAAPAPAWRPGLEEVSRLQWRIYRSHPWLASTMSFTRPVLAPDAALHTERAISALAGLGLSWEEMAQASVSLAAFTCGLAVHFEREAQAEQDSGMSAEEWMERLDDEDHDRLMSDPERFPMFDALNRGPEIDLGLDALFEFGLARMLDGVGALIAARGGATGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDF9</accession>
    <name>A0A1E7NDF9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene240"/>
    <dbReference type="EnsemblBacteria" id="OEV38523">
        <property type="protein sequence ID" value="OEV38523"/>
        <property type="gene ID" value="HS99_0020920"/>
    </dbReference>
    <dbReference type="OMA" id="HNIHIAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="42068" checksum="FB1870D75CF93E8E" modified="2017-01-18" version="1">MIGDARVVGLGEATHGSHEFFTMKQRVFRYLVEEKGFTTFALEASWSAGLLIDAYVQGEAEGDGDARRLVRRTLAGSPWQRREFADLIEWMRAYNRSHPQRPVHFVGTDLGFPGIGEQPFAEVTAYVRKAAPASLSSVEQLYAGLRPFDDAIGYLTRVPLPQRQRNADLAQQALDLVTAAGKDGDAQYEWAVQHARNIARTFAFSTMRADDAPSVTAAQLLRDRAMADNTLWWQRRLGGKVLLSAHNGHIGYRSSAPALYPTTQGSHLRDALGDGYVSIGFTFGGGSFLTGTDPFAGNWQSTTVPPATLGMNEYLLDRVRPRDYYLDLRQAPPAARTWLDTAHPTYDAGTTFSRDPLPTLALGAGYDVLIHLHRVRAAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR9</accession>
    <name>A0A1E7NDR9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556315.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5121"/>
    <dbReference type="EnsemblBacteria" id="OEV38840">
        <property type="protein sequence ID" value="OEV38840"/>
        <property type="gene ID" value="HS99_0019435"/>
    </dbReference>
    <dbReference type="OMA" id="YESEWHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="876"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="965" mass="101367" checksum="01767DB0AA225011" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB8</accession>
    <name>A0A1E7NEB8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366270.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4384"/>
    <dbReference type="EnsemblBacteria" id="ARF83244">
        <property type="protein sequence ID" value="ARF83244"/>
        <property type="gene ID" value="B6264_30355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39014">
        <property type="protein sequence ID" value="OEV39014"/>
        <property type="gene ID" value="HS99_0018085"/>
    </dbReference>
    <dbReference type="OMA" id="WHTIDEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017101">
        <property type="entry name" value="P-loop_ATP/GTP-bd_All4644_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037081">
        <property type="entry name" value="P-loop_All4644_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18158" checksum="676D0C130804330E" modified="2017-01-18" version="1">MKHSTAPEGVLGPIKPGDLVVMVGCSASGKSSLLAAVPAHQIVSLDRLRAVASAPGDQDATADAVLLQHQILGMRLRRARTSIVDNTSVEQLHRLQLVELAHQYGRRCVAAWVDAPLPTCLARNALRPDHERVPEDVLRWQHAMARAARLTLPNEGFDEIRHHRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG7</accession>
    <name>A0A1E7NEG7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000342.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4084"/>
    <dbReference type="EnsemblBacteria" id="ARF83323">
        <property type="protein sequence ID" value="ARF83323"/>
        <property type="gene ID" value="B6264_30850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39090">
        <property type="protein sequence ID" value="OEV39090"/>
        <property type="gene ID" value="HS99_0018570"/>
    </dbReference>
    <dbReference type="OMA" id="PWRRFDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="26210" checksum="A724F31B98D38401" modified="2017-01-18" version="1">MANFVLVPGAWLGAWAWEDTARALGEHGHTALALTLTGLAERAEEGGPQTDLDTHIADITEFVERNDLRKVTLVAHSYAAAPVTGAAGRLSDRLERVVYVDSAPFAAGMRMLDLMPPEAADQLGQQVTAHGDGWRLPMPPFEVLSLSSSLDGLDEDQRDVLTARATPQPFGTYTQRLADHAAPGPGVDRVLIACRDFTGLLDTGVPMLAFLNNAPWRRFDLPTGHWPMLSAPADLASILHTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ4</accession>
    <name>A0A1E7NEJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000292.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7329"/>
    <dbReference type="EnsemblBacteria" id="OEV38913">
        <property type="protein sequence ID" value="OEV38913"/>
        <property type="gene ID" value="HS99_0018890"/>
    </dbReference>
    <dbReference type="OMA" id="GDCAFCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15745" checksum="F41FD96442C5BA97" modified="2017-01-18" version="1">MKGVAVKDPVLVFDGDCAFCSSCVRWGEKYLRQTLASGGWEAVPFQFAELAELDALAGGRAEVSPERAEREVLWVTPAGRVYGGAQAVARLLMRSGGAWAYLGALMALGPVRPVAGVVYRWVSRNRHRMPGGTAACALPRRGPVQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ3</accession>
    <name>A0A1E7NEZ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550219.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000389.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3612"/>
    <dbReference type="EnsemblBacteria" id="ARF82473">
        <property type="protein sequence ID" value="ARF82473"/>
        <property type="gene ID" value="B6264_29600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39276">
        <property type="protein sequence ID" value="OEV39276"/>
        <property type="gene ID" value="HS99_0000735"/>
    </dbReference>
    <dbReference type="OMA" id="AVRIYHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="25305" checksum="B47D4F6C3A2DD7E0" modified="2017-01-18" version="1">MSERVVPEPRRRRRRPTKQGVVLSQELIIDTALRLIEQHGAEALTVRRLGAALGADPSAVYRYFHSTDDLLLAIADELIGLAQADWRATGDWRADLRAIGLRIHSAYLAHPQAAVLAAHRTTGRTHETAAVEAILSVLRTAGFPDQEAVRIYHAFVDQSLGFAALDAAALALPAAAATADLRVWQSSYARLDATTHPHIAATAHLLTADMRSSGYPYALDLLIDAAGARLAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF32</accession>
    <name>A0A1E7NF32_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284896.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3652"/>
    <dbReference type="EnsemblBacteria" id="OEV39311">
        <property type="protein sequence ID" value="OEV39311"/>
        <property type="gene ID" value="HS99_0000935"/>
    </dbReference>
    <dbReference type="OMA" id="PRVVMGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="182"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="36037" checksum="6B5BB97B2676983F" modified="2017-01-18" version="1">MADTLQTAPDFSGWSCPLPLRDHPVVVMGHGGGGALSAELVRHLFLPAYGGEQLEGLGDSAQLTLGGARLAFSTDSYVVRPLFFPGGSIGDLAVNGTVNDLAMSGAVPAYLSCAFVLEEGTELATVGAVAQAVGAAARAAGVTVATGDTKVVDAGHGDGVYLTTAGIGLIPDGVDIRPQRARPGDVIMVSGPIGQHGIAIMSVREGLEFGAEVTSDTAALGSLVQAMLAVTPELHVLRDPTRGGLAASLNEIAAASGTGVVLEDRAVPVPEAVANACAFLGLDPLYVANEGRLVAFVPREHAEAVLAAMRAHPDGRGTVIVGECVADHPGVVVARTGLGGTRIVDLPLGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF66</accession>
    <name>A0A1E7NF66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284981.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000389.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3611"/>
    <dbReference type="EnsemblBacteria" id="OEV39275">
        <property type="protein sequence ID" value="OEV39275"/>
        <property type="gene ID" value="HS99_0000730"/>
    </dbReference>
    <dbReference type="OMA" id="RDHHGAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="545" mass="57989" checksum="65B47CBBAC972868" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE1</accession>
    <name>A0A1E7NFE1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="14" type="ORF">HS99_0001435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000615.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1576"/>
    <dbReference type="EnsemblBacteria" id="OEV39394">
        <property type="protein sequence ID" value="OEV39394"/>
        <property type="gene ID" value="HS99_0001435"/>
    </dbReference>
    <dbReference type="OMA" id="KVMKGML"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="13">
        <location>
            <begin position="11"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="12">
        <location>
            <begin position="446"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="22"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="451"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="451"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV39394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="778" mass="84963" checksum="AF42143098DB14C5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ4</accession>
    <name>A0A1E7NFJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39457">
        <property type="protein sequence ID" value="OEV39457"/>
        <property type="gene ID" value="HS99_0001795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="7245" checksum="881E9209724B7AA1" modified="2017-01-18" version="1">MRRADERAPHEAVRSAARDDQARPADRVAHAEHHAPGWPATDSSLTYDRITLSREPTTHCSGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN8</accession>
    <name>A0A1E7NFN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39521">
        <property type="protein sequence ID" value="OEV39521"/>
        <property type="gene ID" value="HS99_0002190"/>
    </dbReference>
    <dbReference type="OMA" id="WELVEPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20304" checksum="6658700ECD6529F3" modified="2017-01-18" version="1">MSTHPSRRNPVRRTSDRIQWWLARVLLAVMVIGLPAAAVSAGLLTYRAQMHTGHVESSARHTVTAHLTAAAPVPSNNDYSRVPATAAWTAADGTTHTATVRMWPGERAGTPVPLWVDHQDTVTSAPLTRGQAAAAAWTTAAMTAGTLSLLCLAAWKGSVCVLDHHRYAQWDAEWSQVEPRWSKRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>S4S389</accession>
    <name>S4S389_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ctc5</name>
        <name evidence="6" type="ORF">HS99_0013390</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Metab. Eng." volume="19" first="69" last="78">
            <title>Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Cheng X."/>
                <person name="Liu Y."/>
                <person name="Deng Z."/>
                <person name="You D."/>
            </authorList>
            <dbReference type="PubMed" id="23800859"/>
            <dbReference type="DOI" id="10.1016/j.ymben.2013.06.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">F3</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762</strain>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="HM627755">
        <property type="protein sequence ID" value="AEI98641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282630.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5226"/>
    <dbReference type="EnsemblBacteria" id="ARF80648">
        <property type="protein sequence ID" value="ARF80648"/>
        <property type="gene ID" value="B6264_18610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33545">
        <property type="protein sequence ID" value="OEV33545"/>
        <property type="gene ID" value="HS99_0013390"/>
    </dbReference>
    <dbReference type="OMA" id="TFYTHPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="104"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AEI98641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="50680" checksum="9B5D4D6BEB95B23F" modified="2013-10-16" version="1">MGKQQQFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFEEGIGFDGSAIEGFARVYESDMIAKPDPTTFQILPWRSETPGTARMFCDILMPDGSPSYADPRFVLKRTLEKASDLGFTFYTHPEIEFFLLKNLPGDGTAPIPADQSGYFDHTPRGVGHDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNIMTFRLVMKEVALEQGVHASFMPKPFSEHPGSGMHTHVSLFEGDRNAFHESGAEYQLSKVGRSFIAGLLRHAAETAAVTNQWVNSYKRIWGGSQRTAGAGGEAPSYICWGHNNRSALIRVPMYKPGKQGSTRIEVRSLDTGCNPYLAYAVTLAAGLKGIEEGYELPPGADDDVWALTDSERRALGIQPMPQNLGEAIDLMQRSELVAETLGEHVFDFFLRNKRQEWEEYRSEVTPFELRKNLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUX7</accession>
    <name>A0A1E7MUX7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000101">
        <property type="protein sequence ID" value="OEV32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291207.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000696.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000123_gene6316"/>
    <dbReference type="EnsemblBacteria" id="ARF77564">
        <property type="protein sequence ID" value="ARF77564"/>
        <property type="gene ID" value="B6264_00250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32246">
        <property type="protein sequence ID" value="OEV32246"/>
        <property type="gene ID" value="HS99_0040330"/>
    </dbReference>
    <dbReference type="OMA" id="FGYCLGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14618" checksum="E4837E319D10249B" modified="2017-01-18" version="1">MQTDPRGPRFAAALTAVVLAAVLITGSGLLLAAQTLVFVLGAVGGPRVSPYSWLFHVFIAPHLTPPTETQDERPLRFTQGGGAVFAAVGTLGYLTGVTWLGLLSTGFALAAAFLNAVFGYCLGCEIYPIVRRAQGRLGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV08</accession>
    <name>A0A1E7MV08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2968"/>
    <dbReference type="EnsemblBacteria" id="OEV32264">
        <property type="protein sequence ID" value="OEV32264"/>
        <property type="gene ID" value="HS99_0016230"/>
    </dbReference>
    <dbReference type="OMA" id="YPGDGTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="29863" checksum="02C1C9BFED31F68C" modified="2017-01-18" version="1">MHVFVTGGTGLIGSAVIAELLGNGHSVLALARSDASALAAEAAGAEPLRGALADLDVLRSGAAQADGVIHLAFANDFSSPDAVARAVAEESAALATLGEELIGTGRPLVTCSGTPHVPGRASTEADPLPTDGPVGGRGRAVTAVLGLASRGVRSTAVRLPRTVHNQGTGGFAGLLTDIARRTGVSGYPGDGTQRWPAVHALDAAVLFRLALEQAEAGTSWHAVGDEGDQVRDIAAVIGRRLGLPVESVPPQTYGALGPIFANDQPSSSARTRQTLGWEPKHLSLLEDLENIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVA6</accession>
    <name>A0A1E7MVA6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5-oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553819.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6945"/>
    <dbReference type="EnsemblBacteria" id="OEV32355">
        <property type="protein sequence ID" value="OEV32355"/>
        <property type="gene ID" value="HS99_0016785"/>
    </dbReference>
    <dbReference type="OMA" id="TDCNVML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="PTHR11365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydant_A_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_A" evidence="2">
        <location>
            <begin position="203"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase_B" evidence="3">
        <location>
            <begin position="684"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1190" mass="126961" checksum="1A48539719A44513" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW45</accession>
    <name>A0A1E7MW45_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="12" type="ORF">HS99_0015345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3132"/>
    <dbReference type="EnsemblBacteria" id="OEV32644">
        <property type="protein sequence ID" value="OEV32644"/>
        <property type="gene ID" value="HS99_0015345"/>
    </dbReference>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="11">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="640" mass="68149" checksum="6910D404354BEB25" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW96</accession>
    <name>A0A1E7MW96_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="7" type="ORF">HS99_0015585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288298.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3181"/>
    <dbReference type="EnsemblBacteria" id="ARF78273">
        <property type="protein sequence ID" value="ARF78273"/>
        <property type="gene ID" value="B6264_04500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32689">
        <property type="protein sequence ID" value="OEV32689"/>
        <property type="gene ID" value="HS99_0015585"/>
    </dbReference>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="518" mass="58274" checksum="97CDCE3194C8890B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW98</accession>
    <name>A0A1E7MW98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288307.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3186"/>
    <dbReference type="EnsemblBacteria" id="ARF78268">
        <property type="protein sequence ID" value="ARF78268"/>
        <property type="gene ID" value="B6264_04475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32694">
        <property type="protein sequence ID" value="OEV32694"/>
        <property type="gene ID" value="HS99_0015610"/>
    </dbReference>
    <dbReference type="OMA" id="GPYEWSR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="11725" checksum="6F8A4BB12B5589B7" modified="2017-01-18" version="1">MSSAETATAAAPDARTERRAKRIAKHLTSFAQQHGGSADAVVEYVGAVATRIVVVGADGAWGDQVAPTYAVGRRAAELAGLTLHENFEGELGLKVKTSAYEWKRMAGIQLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWB0</accession>
    <name>A0A1E7MWB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7850"/>
    <dbReference type="EnsemblBacteria" id="ARF78242">
        <property type="protein sequence ID" value="ARF78242"/>
        <property type="gene ID" value="B6264_04305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32718">
        <property type="protein sequence ID" value="OEV32718"/>
        <property type="gene ID" value="HS99_0015780"/>
    </dbReference>
    <dbReference type="OMA" id="HEPARQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="428" mass="42268" checksum="2D714DB361F1CEB7" modified="2017-01-18" version="1">MRGETARDVQHEPARQGRHGRPRPFGGRLRLPTLRFSGAAMAMSTVVGISIATTLLLNEQQGIGRRAGVARVGTTPPPSPGATDQAEAASDRTTDTPAPPSGHPHGPKPPEHSSAHPSGPANAAATPPGGLRAGTAAPVTPSTGGQASAEHDPRSAAGTPANGTGTGGQPGTGASPSAQPSTPSPSFTPSTGQPGAGHAGAAQAGAGQADAGQSPLSPGLQPTTPARPGPAFPAPGRPLPPPPVTDAPDGHAPGTGTPTTGAPAADAPTTDAPAADGSAPEADQALTGAGLTTAVGRDGLRHALDLTVAEPVTALQAEFRLAPGQLAPGSGAAWTDLPSAVVTAQQERGTLVYRFTTPPGTDVEPGRYSFVVRGTRPADQAGPVRKPGPQETWNAAAFGIDHPRAVAALGGFGPLLPQSAQHLAHPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI2</accession>
    <name>A0A1E7MWI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3857"/>
    <dbReference type="EnsemblBacteria" id="OEV32788">
        <property type="protein sequence ID" value="OEV32788"/>
        <property type="gene ID" value="HS99_0015285"/>
    </dbReference>
    <dbReference type="OMA" id="TMQYYTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="34164" checksum="71B7B0CC44AAC3E7" modified="2017-01-18" version="1">MLRRKRRREAARTLAFLSPWLIGFGVFFVYPLVSTAYFSFTQYNGFGSPTFNGLKNWNYVLDELPTFWQGLRNTVWLVLVMVTLRVAFGLGIGLLITRVKTGAGFFRTVFYLPYLAPPVAATVAFAFLLNPGTGPLNHLLGELGLPQPGWFADPNWSKPALTLLAMWGIGDLMVIFMASLLDVPKEQYEAAELDGAGPFQRFRYVTLPNVSPIIMFAVVTGVIQTMQYYTQAIVAGKVASGIAGNSGQQFEPGFPQGSTWTLPQMVYNLGFQRFNYGAACVVALVLFAISMAVTSILLRRRSGFMSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWT4</accession>
    <name>A0A1E7MWT4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0039555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene91"/>
    <dbReference type="EnsemblBacteria" id="OEV32906">
        <property type="protein sequence ID" value="OEV32906"/>
        <property type="gene ID" value="HS99_0039555"/>
    </dbReference>
    <dbReference type="OMA" id="QDVETHN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGRP" evidence="3">
        <location>
            <begin position="161"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="36852" checksum="6BDCF215251AE6CA" modified="2017-01-18" version="1">MLLQPASAASAAPPPSGAERHVFPGGGTTTSLPLTSGHGLAPSTTRPYELLGVVWDGPAGALNGGSVRVRTRDAATGRWSDWHTLEADAEDGPDDAPHGATAPLWTGRSDGVAVDVRPGPAGLPPGLRVDLVDPGAGAPAAAAPRTLPAAPADGDHRAPRPGIVTRAGWGADESLREPGFEYTGPVREVFVHHTATATDYACSDAPRVIRSIYQYHVKTSGWRDIGYNFLVDRCGTIYEGRAGGVAQPVHGAHTLGFNTDSSGVAAIGTFVSDNPPQALLDGITAISAWKLGLTGQAADGHTKLTSGSDASRYPKGTVVEFDAISGHRDAFNTECPGEALYARLPALRTAAAKLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW5</accession>
    <name>A0A1E7MWW5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387605.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5779"/>
    <dbReference type="EnsemblBacteria" id="ARF81345">
        <property type="protein sequence ID" value="ARF81345"/>
        <property type="gene ID" value="B6264_22725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32935">
        <property type="protein sequence ID" value="OEV32935"/>
        <property type="gene ID" value="HS99_0013705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30543" checksum="CBBB8189FE21D616" modified="2017-01-18" version="1">MTIDQGTARAELGVIGGSGLYALLDEVTEVRVDTPYGPPSDALFVGEVAGRRVAFLPRHGRGHGLPPHRINYRANLWALHSLGVRQVLGPCAVGGLREEYGPGTLLVPDQFVDRTAGRVQTYYDGQPLPDGSVPGVVHVPMADPYCPAGRRAVLEAARESAWEPVDGGALVVIEGPRFSTRAESRWFTANGWSAVGMTGHPEAVLARELGLCYTSSALVTDHDAGVEAGDGVTHAEVLEVFAGNVGRLRTVLFKALERLPAERDCVCSHALDGVATGLPGVGEGLPGVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX25</accession>
    <name>A0A1E7MX25_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">HS99_0014025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5715"/>
    <dbReference type="EnsemblBacteria" id="OEV32988">
        <property type="protein sequence ID" value="OEV32988"/>
        <property type="gene ID" value="HS99_0014025"/>
    </dbReference>
    <dbReference type="OMA" id="DRTYKQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="26634" checksum="C58E0F6528665004" modified="2017-01-18" version="1">MTIDLNADLGEGFGRWTLTDDDALLSVVTSANIACGFHAGDPSTMRRVCELAAERGVRIGAQVSYRDLAGFGRRAMDVPPDELADEVAYQIGALQAFARGAGARVAYVKPHGALYNRTVHDEEQAEAVVRGVGLAAPGLPVLGLPGSRLHEAAGRAELPVVAEAFADRAYTPHGTLVPRREPDAVVHDPEAVVRRSVTIARDGEVTARTGDRIRLRARSLCVHGDTSGAADLARRVRTALRAAGVRVEAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ9</accession>
    <name>A0A1E7MXJ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0014635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33167">
        <property type="protein sequence ID" value="OEV33167"/>
        <property type="gene ID" value="HS99_0014635"/>
    </dbReference>
    <dbReference type="OMA" id="GFQRARD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13532" checksum="7AA34E703A025E40" modified="2017-01-18" version="1">MPAQETTVASPSAPTTATGLTVQVRRTADGAAVCSLTGDLDVETLTEARTALEGATVSRPTLLVADLEHVGFCDSSGLNLLLKTRMNASTAGIPFRLAAPSHAIMRLLDITGANSVFSLHTSVDEALSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX2</accession>
    <name>A0A1E7MXX2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="14">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HS99_0038850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 15">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="14"/>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286959.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000761.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6792"/>
    <dbReference type="EnsemblBacteria" id="ARF78590">
        <property type="protein sequence ID" value="ARF78590"/>
        <property type="gene ID" value="B6264_06405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33282">
        <property type="protein sequence ID" value="OEV33282"/>
        <property type="gene ID" value="HS99_0038850"/>
    </dbReference>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="40098" checksum="375AF47375B3AFF7" modified="2017-01-18" version="1">MSTPTQAPITFDLKPSAHPLPAAEREARLTNPGFGRVFTDHMVTIRWTEGRGWHDAQLVPYAPVEMDPANMTLHYGQAIFEGLKAYRQADGSIATFRPEANALRFQASARRLAMPELPVETFVEAVELLVQQEQGWVPSEPEQSLYLRPFMFATEVGLGVRPANSYLFMIIASPAGAYFQGGIKPVSVWLSKEYVRAAPGGTGAAKCAGNYAASLVAQAQAAEKGCDQVVWLDAAEHRWVEEMGGMNLYFVFGEGKDARIVTPELSGALLPGITRDSLLQLAADLGYAVEERKISTDEWQQANADGTLTEVFACGTAAVITPVGSVKSAAADWTVGNGEPGPITMELRRALLAIQGGQQPDTHNWLHKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY84</accession>
    <name>A0A1E7MY84_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553431.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3980"/>
    <dbReference type="EnsemblBacteria" id="ARF80509">
        <property type="protein sequence ID" value="ARF80509"/>
        <property type="gene ID" value="B6264_17775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33405">
        <property type="protein sequence ID" value="OEV33405"/>
        <property type="gene ID" value="HS99_0012550"/>
    </dbReference>
    <dbReference type="OMA" id="GKDKCDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="35535" checksum="26EE4CA0F40DE5A3" modified="2017-01-18" version="1">MAEQAAPATAREWHLAARPQGWPVPADFALVEAPVRTPGPGEILVRNTHLSVDPYMRGRMNDVKSYVPPFQLGRAMDGGAVGYVVASEAEGFAPGDAVLHGLGWREYATLDAKHAVKVDPEAAPLSAYLGVLGMPGLTAYAGLLAVGGLKEGDKVFVSGAAGAVGSLVGQIAKLKGASLVVGSAGSAEKVAKLVDEYGFDAAFNYKDAPVAEQLAKAAPEGIDLYFDNVGGDHLEAAIGALGVHGRAVLCGAIAQYNETTAPAAPRNLAMAIGKRLRLEGMLVRDHAALQPQFVTEVAGWLRSGELRTEETVVDGFENAAQAFIDLLRGVNTGKMVVRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYD5</accession>
    <name>A0A1E7MYD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0012835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288740.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6591"/>
    <dbReference type="EnsemblBacteria" id="ARF80559">
        <property type="protein sequence ID" value="ARF80559"/>
        <property type="gene ID" value="B6264_18055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33455">
        <property type="protein sequence ID" value="OEV33455"/>
        <property type="gene ID" value="HS99_0012835"/>
    </dbReference>
    <dbReference type="OMA" id="KRYITDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="854" mass="92707" checksum="CD6281FC1E3B11E4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYD9</accession>
    <name>A0A1E7MYD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4190 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6598"/>
    <dbReference type="EnsemblBacteria" id="ARF80563">
        <property type="protein sequence ID" value="ARF80563"/>
        <property type="gene ID" value="B6264_18090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33460">
        <property type="protein sequence ID" value="OEV33460"/>
        <property type="gene ID" value="HS99_0012870"/>
    </dbReference>
    <dbReference type="OMA" id="DTDGMAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10044" checksum="5F0C692A4BFB9604" modified="2017-01-18" version="1">MSTATDRGITDPAGTDRRRTAEAEADSLAVASFLLGLPGLLLFNIVLGPIAITLATLALVRGTSRRGRAFLGLALGIASLAILAVTTATSHGVLIDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE9</accession>
    <name>A0A1E7MYE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288694.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6612"/>
    <dbReference type="EnsemblBacteria" id="ARF80574">
        <property type="protein sequence ID" value="ARF80574"/>
        <property type="gene ID" value="B6264_18155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33470">
        <property type="protein sequence ID" value="OEV33470"/>
        <property type="gene ID" value="HS99_0012935"/>
    </dbReference>
    <dbReference type="OMA" id="VQICEEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="34728" checksum="4EA92E264B02A120" modified="2017-01-18" version="1">MTFTFGIYPGGSLGDETGLIEPVRPDDPERITAALRELQGDAEEFLVRAYRSYAADEHRTPERPERYATDGRKLDLVLQFGVRSGELDGWTDYVRQVVRTEGPRLAVVQICEEPNLDLPILDGSIPNVLRALVEGVIAAKEEALTCGYGHLAVGFNAVPSFDPADTFWPELGELADECFHRSLDYVGLDFFPDVFRAVPEGRLVDSVGAVLTGFRENALPRAGIGPAVPLRVCENGWPTGPGRSEERQAEVVEQVVRTVVGLAGRLGVRSYSFFGLRDADSAGPGLFHHFGLLRDDWTPKPAFDVYRKLVGELTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR8</accession>
    <name>A0A1E7MYR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282681.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5247"/>
    <dbReference type="EnsemblBacteria" id="ARF80666">
        <property type="protein sequence ID" value="ARF80666"/>
        <property type="gene ID" value="B6264_18710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33561">
        <property type="protein sequence ID" value="OEV33561"/>
        <property type="gene ID" value="HS99_0013490"/>
    </dbReference>
    <dbReference type="OMA" id="GRSPFGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="22501" checksum="E81B07595EA88C8A" modified="2017-01-18" version="1">MGNKRRVTPTVYVSVDVEADGPIPGPYSMVSFGAVVAGWDDGEGFRRAEVGAAGFYRELRPISAEYVPEALAVSGLERAALEAGGAEPGVALQEFGRWVERVRTGPEGRRYRPVMVAYPAVYDWQFLYWYLMRFTGSSPFGHSGCLDLKTLYAARAGVPFAGIGKRSMPAELLPDLPHTHHALDDAREQAVLFANLWEWPGPGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYW4</accession>
    <name>A0A1E7MYW4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetracenomycin C resistance and export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553415.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3960"/>
    <dbReference type="EnsemblBacteria" id="ARF80528">
        <property type="protein sequence ID" value="ARF80528"/>
        <property type="gene ID" value="B6264_17875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33423">
        <property type="protein sequence ID" value="OEV33423"/>
        <property type="gene ID" value="HS99_0012650"/>
    </dbReference>
    <dbReference type="OMA" id="IWGMVIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="534" mass="54556" checksum="BE5979C9CF39DB6A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ1</accession>
    <name>A0A1E7MYZ1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000100_gene7486"/>
    <dbReference type="EnsemblBacteria" id="OEV33631">
        <property type="protein sequence ID" value="OEV33631"/>
        <property type="gene ID" value="HS99_0038710"/>
    </dbReference>
    <dbReference type="OMA" id="PYREMAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="228"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="843"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1459" mass="153667" checksum="E1408A42B03A3A12" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ7</accession>
    <name>A0A1E7MYZ7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name evidence="3" type="ORF">HS99_0038560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286421.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1094"/>
    <dbReference type="EnsemblBacteria" id="ARF78979">
        <property type="protein sequence ID" value="ARF78979"/>
        <property type="gene ID" value="B6264_08665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33641">
        <property type="protein sequence ID" value="OEV33641"/>
        <property type="gene ID" value="HS99_0038560"/>
    </dbReference>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="31030" checksum="2DF793AB900D8A26" modified="2017-01-18" version="1">MSTTDPTPDSHLLGAADIRELAAAFGVKPTKQRGQNFVIDGNTVRRIVRAAEVTEQDAVVEVGPGLGSLTLALLEVARHVTAVEIDPVLAQHLPDTVAARMPGKADSFDLVFSDAMEVTELPGPAPTALVANLPYNVAVPVLLHMLATFPSIERTLVMVQSEVADRLAAKPGNKVYGVPSVKANWYAEVKRAGAIGRNVFWPAPNVDSGLVSLVRREPPKTSASRAEVFAVVDAAFAQRRKTLRAALAGWAGSAAGAEQALAAAGIDHKLRGEMLTVEQFAAIAEHKPVRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS1</accession>
    <name>A0A1E7MZS1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280352.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2157"/>
    <dbReference type="EnsemblBacteria" id="ARF77792">
        <property type="protein sequence ID" value="ARF77792"/>
        <property type="gene ID" value="B6264_01600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33940">
        <property type="protein sequence ID" value="OEV33940"/>
        <property type="gene ID" value="HS99_0010760"/>
    </dbReference>
    <dbReference type="OMA" id="GEWPLPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33929" checksum="4D41FE308BE73C93" modified="2017-01-18" version="1">MGERSDHPQGPGAAEYSGAPEIEATVVLGLRITDWPALRAAAIRAVEELDFEGIDPAGQRRELLREVAEDANAALGALLHPDRLVAAIPGVEAIGGTLEISVTEDFTPDFAELFPLDGEDEDGGAGADWTLTPRTACLLHAQLLGLADAAYDDLDEHGDDPVVDGEDVDWTVFARLPQRTWRLHRGWRRAMARAFDDLADDLALGEWPLPRCLAEEIALRMALVDARTLLGSQPESVADMMGDLPADLYDYDWDGCHDELFGVYGPDDGDPELGAEQRTELLLAATHPEGWFLMYEDAEERDPQRGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS6</accession>
    <name>A0A1E7MZS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000642.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1878"/>
    <dbReference type="EnsemblBacteria" id="ARF77783">
        <property type="protein sequence ID" value="ARF77783"/>
        <property type="gene ID" value="B6264_01540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33932">
        <property type="protein sequence ID" value="OEV33932"/>
        <property type="gene ID" value="HS99_0010700"/>
    </dbReference>
    <dbReference type="OMA" id="IAGRTMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="50181" checksum="1178041F27F912BF" modified="2017-01-18" version="1">MATAAAVPGPAGNPLVGSLFDLTRRPLRTYLAARRDHGDVVRFLAGPPGLRVEFYGVFSPEGVHQVLGSEVANFRKENNFYDELRTSVGNGLLTSQDEVYQRQRRLIQPLFTRRRVDGYADALAQEAQALAERWRAVPDGVVDAAEEMSRFALRAVARILFGADVEEAVEVVNRSFPAVGEYIMERGFAPVRLPRTWPTPGNRRGLAAQRALYEVCDRIIAERAARGGGDEDADDLLTLLGRARGEDGERLDPAELRDQVLVFLLAGHETTATSLAFALHLLAKHPEQRKLAQEEARTVLAGRAPTAADLERLPYITRVLKEAMRLFPAASLVGRRAVEETVIDGYVIPAGAQLVVAPLVTHRHPDHWAEPERFDPDRFLPEAEKARHRYAWFPFGGGPRACIGQHFSMLESVLTLGVLLRDFEVEVVDRRVALAQGITLRAASAMRVRVSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D8</accession>
    <name>A0A1E7N0D8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2198"/>
    <dbReference type="EnsemblBacteria" id="OEV34160">
        <property type="protein sequence ID" value="OEV34160"/>
        <property type="gene ID" value="HS99_0010965"/>
    </dbReference>
    <dbReference type="OMA" id="QPYNYPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016899">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015213">
        <property type="entry name" value="Cholesterol_OX_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09129">
        <property type="entry name" value="Chol_subst-bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198613" evidence="2">
        <location>
            <begin position="32"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="609" mass="65116" checksum="C53A5739F5919E7A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K5</accession>
    <name>A0A1E7N0K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551754.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000765.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2241"/>
    <dbReference type="EnsemblBacteria" id="OEV34003">
        <property type="protein sequence ID" value="OEV34003"/>
        <property type="gene ID" value="HS99_0011165"/>
    </dbReference>
    <dbReference type="OMA" id="RLLGYWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="110"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="41945" checksum="36CA1A82A387AD02" modified="2017-01-18" version="1">MTATETPTTAANTVTAARTTTAANTATAERQIVPPEEKHAAELEFLAAHDSGPRPPGWRLTPRAVVTFVMGSGGEKLKAGRRSLVIEPKFVGERALVERCVVTLAGERGLLLVGEPGTAKSMLSELLAAAVCGTSALTVQGTAGTTEDQLKYGWNYALLLAKGPSREALVPSPVLTAMTTGAVARVEEVTRCLPEVQDALVSLLSERRIAVPELAGTPDGQLHAAAGFTLIATANLRDKGVSEMSAALKRRFNFETVGPIGSLAAEVELVRRQSTTAVARAGAGYAVDDAVLEALVTAFRDLRTGRSTEGWDVERPSTVMSTAEAVSVATALGVTAAYLPDGGDLLGRLPGQLLGVVRKDDPADAARLLGYWDGPVRRRAEQGAATWRTLWDLRSALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N1</accession>
    <name>A0A1E7N0N1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554596.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6075"/>
    <dbReference type="EnsemblBacteria" id="ARF78165">
        <property type="protein sequence ID" value="ARF78165"/>
        <property type="gene ID" value="B6264_03860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34248">
        <property type="protein sequence ID" value="OEV34248"/>
        <property type="gene ID" value="HS99_0036960"/>
    </dbReference>
    <dbReference type="OMA" id="DNTDEQW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="25791" checksum="159440CE290A11E3" modified="2017-01-18" version="1">MDLGLKNKAYVVTGATRGLGLATARELVAEGAHVLVSGRTQDAVDAAVTELAALGTAHGLVADNAGPDTADRLIAEANERFGRFDGILISVGGPQAGPVETTPESAWRDAFESVFLGALRLARTAAAALPSGGVIGFVLSSSVRQPIPGLGISNGLRPGLAMAAKSLADELGPRGIRVLGLLPGRIDTDRVRELDALAPDPAAARAEAGATIPLRRYGTPQEFGRVAAFLLSPAASYLTGVMVPVDGGALRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Z2</accession>
    <name>A0A1E7N0Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387109.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3725"/>
    <dbReference type="EnsemblBacteria" id="ARF77997">
        <property type="protein sequence ID" value="ARF77997"/>
        <property type="gene ID" value="B6264_02795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34133">
        <property type="protein sequence ID" value="OEV34133"/>
        <property type="gene ID" value="HS99_0011940"/>
    </dbReference>
    <dbReference type="OMA" id="IELRIAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005509">
        <property type="entry name" value="AfsA_hotdog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03756">
        <property type="entry name" value="AfsA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="AfsA" evidence="1">
        <location>
            <begin position="223"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="35151" checksum="0C27E2F85AE69A8E" modified="2017-01-18" version="1">MSDSGTLLEPAACHAVTGKLVHKLDPDEAFLTMWRRTGPDTFSVIAHWPSDRPFYRSADGGFDFLLPSETVRQLFPLISHVGYDTPFEHHLVWEHYRYDLDPALLRADSGPVALELRVTCSDLVRRRTGLAGMTMDVDILRNGIRLASATSRFTVQAPAIYRRLRGSNSDRARAMASAPPAPEGIPAPLTGRPDQADVVLSEIPPVDVPERIADEMSGLLRPNSGSWWLRVDATHRTYFDHPVDHVPGALLLEAARQATQALRYPTPAPPLAMSAAFLRYVDLDAPCRITARVESPTLVRVTAEQHDRLCFTSEVGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N131</accession>
    <name>A0A1E7N131_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="3" type="ORF">HS99_0035895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7199"/>
    <dbReference type="EnsemblBacteria" id="OEV34397">
        <property type="protein sequence ID" value="OEV34397"/>
        <property type="gene ID" value="HS99_0035895"/>
    </dbReference>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="30126" checksum="B030FFFBFAC5A785" modified="2017-01-18" version="1">MTATAPIPQQSPSARLSAAPAAYPAPMYPHKATEEQHRERRIRSFQPRRGRMTNAQASALDRSWERYGVPIDGTPLDLAELFGGLPVTLEIGFGMGETTAAMAAADPSMGILAADVHTPGHGNLLGMLERDGSQNVRLAAGDAVILLRDMLPDASLAGLRVYFADPWPKPKHHKRRLVQASFLDLVLPRLAPGALVHCATDWEPYAEQMLEVLSASPELENLHPEGDGTGWLEPADHPDGSVPGYAPRPDWRPVTKFERAGIAKGHVVHDLLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B5</accession>
    <name>A0A1E7N1B5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0035825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene368"/>
    <dbReference type="EnsemblBacteria" id="OEV34472">
        <property type="protein sequence ID" value="OEV34472"/>
        <property type="gene ID" value="HS99_0035825"/>
    </dbReference>
    <dbReference type="OMA" id="HISWARR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20925" checksum="1699DCFC4D88F19A" modified="2017-01-18" version="1">MGVKREQRQRQDAEFSAFVAGSGRQLLRLAELLTGDPERAKDIVQSALERAYLHWHRITGDDPIAYVRRIVVNQHRDWWRRLRNRELPTDHAPDRPLAEDLAERQAERALLHQALGTLTRRERTVVVLRYYGDLTEAAVAAELGIARGTVKSTLNRAMSKLRAHPELADRTGGPAGATTHIEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W4</accession>
    <name>A0A1E7N1W4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81959">
        <property type="protein sequence ID" value="ARF81959"/>
        <property type="gene ID" value="B6264_26475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34677">
        <property type="protein sequence ID" value="OEV34677"/>
        <property type="gene ID" value="HS99_0009305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9925" checksum="446ED09FE6CB2362" modified="2017-01-18" version="1">MGRRGHRTDEAHCDGWRTDDGGLCGRRAVPALRFDARVSVVLAFGMGIGTTAVVVPGAFSAGEMTAITLRGPRRSRPQAHFTFDAWSITPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J9</accession>
    <name>A0A1E7N2J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000104_gene7212"/>
    <dbReference type="EnsemblBacteria" id="ARF81953">
        <property type="protein sequence ID" value="ARF81953"/>
        <property type="gene ID" value="B6264_26435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34683">
        <property type="protein sequence ID" value="OEV34683"/>
        <property type="gene ID" value="HS99_0009345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25781" checksum="9B42C6C06FB7B0D8" modified="2017-01-18" version="1">MYESTDTTFVPRYASGFAPNDEVIHNHPLWPPVGQSSPEAPYPVVDGWTNASVQSRTVGVEALMQEIGLPAAGFHPQVIDDRPEHRSRTARPAGRRADVMGSLIGFLTAAVVTVACILGWAISYHPLQNVALSRLPRNLSQYWPVVIYGPWMAASLSVLRAALGGRKVANSWTIILVFAGIASALCIVDTPSTMPEAVVAGLPPVTAVVCLQQMVRQLLAARQVSQDDVRQAPSHRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M1</accession>
    <name>A0A1E7N2M1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288632.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5893"/>
    <dbReference type="EnsemblBacteria" id="ARF82060">
        <property type="protein sequence ID" value="ARF82060"/>
        <property type="gene ID" value="B6264_27095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34934">
        <property type="protein sequence ID" value="OEV34934"/>
        <property type="gene ID" value="HS99_0035080"/>
    </dbReference>
    <dbReference type="OMA" id="AITPDGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="238" mass="25790" checksum="4182C88F6FE4781A" modified="2017-01-18" version="1">MGNDTHLRNKRREGYDGTGAGAITPDGCAVEVWTRLPVGDAPDVIEAAVPPGARILELGCGVGRMTHPLVERGFAVTAVDESAEMLARVREGVRTVRSPIERLDLGERFDVVVLASFLVHAGDPAVRQGLLETCRRHVAEDGCVLVQREGEDWHRNVPRESRIAGTDGVARIVSATPVGSGVNSVHAEYVFPDGTWTQTFLSRPLSTEAFEQALADAGLRVETYLTEDRTWVRARPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M6</accession>
    <name>A0A1E7N2M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0035055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389504.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5888"/>
    <dbReference type="EnsemblBacteria" id="OEV34948">
        <property type="protein sequence ID" value="OEV34948"/>
        <property type="gene ID" value="HS99_0035055"/>
    </dbReference>
    <dbReference type="OMA" id="NTHDVVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="233"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="40022" checksum="3564F7C2399DA106" modified="2017-01-18" version="1">MSGLPRVVDLLAARAEEHDRDATFPYQGIEAVHEAGLLTLTVSPRYGGPGGTLADTVRVLTQLGRGDASVAVVTAFTLLQHAEQARRATWPAAGYRRLLTESRRGPALVNTLRMEPGGRPDALPATLARRDGDGWLLTGRKTYCTGAEALAWMAVTARTDEPEPRVGTFLVRGESEGLEIDPTWDQLGLRASASHDVVLDGVRVPVELALGLRTPGREDVAEAELARAWQDLALAAVAIGVARAAGAWLVRFLNQRTPANLTEPLGTLPRYRCALGEIEAQLIGAEELLHGLAPRVDRGEPDAVARTGPAQLLATRAATAAVQQAVALTGNPGLSRRHPLERYLRDVLSSRVHLAPEEAVLDAAGRAALERGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S6</accession>
    <name>A0A1E7N2S6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287958.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7659"/>
    <dbReference type="EnsemblBacteria" id="ARF82658">
        <property type="protein sequence ID" value="ARF82658"/>
        <property type="gene ID" value="B6264_06025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34998">
        <property type="protein sequence ID" value="OEV34998"/>
        <property type="gene ID" value="HS99_0034735"/>
    </dbReference>
    <dbReference type="OMA" id="LCEVDFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20436" checksum="C2F259C206CAB00E" modified="2017-01-18" version="1">MAEHRQLQRAALLDAARTLLIEGGMEALTFPSLAARTGLARSSVYEYFRSRAAVVEALCEVDFPLWAAEIEAGMASCDTAAGRIEAYVRGQLALAGDPRHRAVMAISAVELDEAARERIRAAHAGLAGLVVQALEDLGHERPRLAAALLQGVVEAAVRRAEQFAAGDRAGCPVESAEAIADAAVSLALHGLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N338</accession>
    <name>A0A1E7N338_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554289.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene384"/>
    <dbReference type="EnsemblBacteria" id="ARF78914">
        <property type="protein sequence ID" value="ARF78914"/>
        <property type="gene ID" value="B6264_08290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35111">
        <property type="protein sequence ID" value="OEV35111"/>
        <property type="gene ID" value="HS99_0034200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20255" checksum="D8DB8AAF8CCA5F02" modified="2017-01-18" version="1">MAAAAVLAAGCGLFYNGYGPMALMDRGSIRSAGEAKGQLDDTLQTAMGAVSPSLSYFGGVYVVERAPEHADGEPSLRSSVTASVSVRTKVAPAKVPVLLDRMKQVWGGECRPEVTTEAGAKRYTDLNCSGRGDTLFTLSVVSSPTVPTEQVLMSAEAFVVRYQPAGDYGASPVGPQLTGHEPGPDLDDPYWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F2</accession>
    <name>A0A1E7N3F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737918.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35217">
        <property type="protein sequence ID" value="OEV35217"/>
        <property type="gene ID" value="HS99_0033395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="10525" checksum="B27CDC2C16C35D28" modified="2017-01-18" version="1">MRADSTVAAAEAAATTPVTANTEGQAPIRFASGCEPPKAATYRPVSAAAAAVPELRRHCRPGRAEQPADQAEGRPEALVVAGRDHRLQFGHRLQEGGLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3M4</accession>
    <name>A0A1E7N3M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282796.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5301"/>
    <dbReference type="EnsemblBacteria" id="ARF80713">
        <property type="protein sequence ID" value="ARF80713"/>
        <property type="gene ID" value="B6264_18980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35287">
        <property type="protein sequence ID" value="OEV35287"/>
        <property type="gene ID" value="HS99_0033040"/>
    </dbReference>
    <dbReference type="OMA" id="VMVHAST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="39311" checksum="D8C4F6815BB62069" modified="2017-01-18" version="1">MASHRRPKPAGRARVSILTGFAAAAVALSAQTGAHADPQPTKEQVKEQVDQLNEQAEQATEKYNAAQEKQQELEKQVSGLQDQVARQQAQVTDLQGGLAEIASEQYRNGGISPTVQLMFSSSPDNFLNQAGALNQAGDTQKNQLKQLQEQQRKLDQDRTEAQGKLAELESTTTQLKASKEDVQNKLKAAQDLLNTLTEQERQAIKAAEEKAAADAKAKADAAAQASQSGSSDRASRDSGRSDLGSGSSSAPVKIAPGSSHGAAALAAAASKVGSPYVWGATGPSSFDCSGLMVWAFNQANVSLPRTSQEQAGAGTRIGTDLSQAQPGDLLIFYSDAHHVGIYAGNGQVLHAPKPGASVRYEAVSNMPLASIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q4</accession>
    <name>A0A1E7N3Q4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550031.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5337"/>
    <dbReference type="EnsemblBacteria" id="ARF80744">
        <property type="protein sequence ID" value="ARF80744"/>
        <property type="gene ID" value="B6264_19160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35320">
        <property type="protein sequence ID" value="OEV35320"/>
        <property type="gene ID" value="HS99_0033220"/>
    </dbReference>
    <dbReference type="OMA" id="GFCVHFS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="812" mass="85968" checksum="09D55318DEF8B9BB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3S7</accession>
    <name>A0A1E7N3S7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2427"/>
    <dbReference type="EnsemblBacteria" id="OEV35351">
        <property type="protein sequence ID" value="OEV35351"/>
        <property type="gene ID" value="HS99_0032560"/>
    </dbReference>
    <dbReference type="OMA" id="AYMLDRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="30715" checksum="ADB00F204C453FEA" modified="2017-01-18" version="1">MSGGGERPELEQVPETALWTLWHRALEARRPDAVLHDPEAVELVDRIDFPFAERFGASGVQGQLQALRVACFDREVADFLAREPRGTVVCLGDGLETQYWRVDNGRAHWLSVDLPESVALREKLLPPGPRQRYLAADATDLDAWADEVDRDQAVLISAQGLLMYLPPARVRSLIAGCAERFPGGSLVLDAVPRWFGRLASAGRIRGRGYQVPPMPWAMDADERDKLRTASPAVVAVRDVRPTGGRGLLGALLPLAMTVPPLASRRLSVTVLDFAERTGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N406</accession>
    <name>A0A1E7N406_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1604"/>
    <dbReference type="EnsemblBacteria" id="OEV35428">
        <property type="protein sequence ID" value="OEV35428"/>
        <property type="gene ID" value="HS99_0032215"/>
    </dbReference>
    <dbReference type="OMA" id="TIVPWEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198742" evidence="1">
        <location>
            <begin position="26"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="44808" checksum="8B64BD49A0B20AFC" modified="2017-01-18" version="1">MKRRLLSLSAATLAGALALSGCSKGSNSGSTSADGVTTIKFVAADYGSNGQNPTQAYWQGVISAFEQQNPKIKVDLQVINWNDIDTQVKTMVQNGNQPDILQTGGYADFAKNGQLYPAQDVLSAGTTGDFLPAMAHAGEQEGTQYGIPFISSARMFLINNELFKKAGLDPANPPKTWADITADATALKKAGVEIPLGVPLGKEEAQGESFIWMLENHGGYQDDKGKYVINSQANIDTFTQLKSWVDAGLTEQSPASVNRTDLAKDFASGKVGMLNGIPTQLNDVKNMDVTWTSMPGKDGASKATLGVADWVMAFKKGGHKEQIKAFLDFAYSKDNTVKFDKEYSLLPVTQSALTALQADPDQKALTPFLQILPTAVFYPLSDPTWPAVSAQVKTQIGSAATDPKKTLDALQQAAQQAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N444</accession>
    <name>A0A1E7N444_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553501.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3885"/>
    <dbReference type="EnsemblBacteria" id="OEV35456">
        <property type="protein sequence ID" value="OEV35456"/>
        <property type="gene ID" value="HS99_0032375"/>
    </dbReference>
    <dbReference type="OMA" id="HYPTDAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="100"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="23514" checksum="12437F2BAC6C5B77" modified="2017-01-18" version="1">MTQTTLPPTPGTAVLPPALRGWLGPVAGSAASVVALLGVRYAGEGGPGRADARVGAAVEGVRPPWRSVALLLDSLGEPVGATALVMAVMTGCLLLRRPRAAVFTVAAVGATVGAATLLKHLVGRTIHGENLSYPSGHTAFATSLALTVALLATGRPGQDGHPSRYGFGLAAALVAGAAMGWAQVALGAHYPTDALAGWCTALALVPVTAWLVDRTADRRARRRADAGRQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C7</accession>
    <name>A0A1E7N4C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5553"/>
    <dbReference type="EnsemblBacteria" id="OEV35540">
        <property type="protein sequence ID" value="OEV35540"/>
        <property type="gene ID" value="HS99_0031705"/>
    </dbReference>
    <dbReference type="OMA" id="IPLWTLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="24739" checksum="0B346D1064BE74C9" modified="2017-01-18" version="1">MGAAWDLRLARAVPFALVCTLIAAAGHALAGGGNVPPTALATGFAAVLVLAVACGGRERSLAAIAGALGAGQLGLHCLFHGFGGSGMHHGSMSVPQAAGRLICNEARPGTLIGLPAGASPEQLVSSAGLDPHAYAAVPGWQGGVLGMTPSMLAGHLAAALVAGWWLRRGEAALWRLVRVAASAAREHWAAPLRSALVLVAALLRGLFGVAGPARRFGAGGGEDRLPASAVLRHSVVRRGPPCGAFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D5</accession>
    <name>A0A1E7N4D5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0032065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386799.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5481"/>
    <dbReference type="EnsemblBacteria" id="OEV35532">
        <property type="protein sequence ID" value="OEV35532"/>
        <property type="gene ID" value="HS99_0032065"/>
    </dbReference>
    <dbReference type="OMA" id="WANETVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198743" description="Peptidase S53 domain-containing protein" evidence="8">
        <location>
            <begin position="30"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="210"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="72792" checksum="EEBCEFFA6A05CCE6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M2</accession>
    <name>A0A1E7N4M2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene941"/>
    <dbReference type="EnsemblBacteria" id="ARF80833">
        <property type="protein sequence ID" value="ARF80833"/>
        <property type="gene ID" value="B6264_19695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35639">
        <property type="protein sequence ID" value="OEV35639"/>
        <property type="gene ID" value="HS99_0006925"/>
    </dbReference>
    <dbReference type="OMA" id="WIELIVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="21758" checksum="8CE187E94F23FF2E" modified="2017-01-18" version="1">MPLMRQPMVCNRVSLITLHAGAGQVARADDPAAVRETLGLIRGLGLQALTELRGLLGVLTPASDQAPSLRGLPTLVEESRRAGLAVGLTVTGPDDGLPAPGPKVQYAAYRIVQEALTNAHKHAPAAEVAVTVAVEPDGLRLAVVNSPAEPAQPAQPTDLAGPVASEGAGPGLPSGGHGLHGMRTRADDLGGTLHAGPTPEGGFAVRARLPLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q9</accession>
    <name>A0A1E7N4Q9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="7" type="ORF">HS99_0007170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281727.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene892"/>
    <dbReference type="EnsemblBacteria" id="ARF80878">
        <property type="protein sequence ID" value="ARF80878"/>
        <property type="gene ID" value="B6264_19940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35681">
        <property type="protein sequence ID" value="OEV35681"/>
        <property type="gene ID" value="HS99_0007170"/>
    </dbReference>
    <dbReference type="OMA" id="SCYPQRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="15187" checksum="EEC1A828C6E6F954" modified="2017-01-18" version="1">MIYLLDTSALVRLLREPKLQAAWYDAIDAESIASCYPQRAEFLYSARDGREYDEISEMFADLYPDVSVPKNAGRWIDTVQRRMALAGQHRSASAVDLMIAATAAHHGLTVLHDDADYRTVARCAPDLSEHSILDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T1</accession>
    <name>A0A1E7N4T1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">HS99_0007270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551114.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000646.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene872"/>
    <dbReference type="EnsemblBacteria" id="ARF80898">
        <property type="protein sequence ID" value="ARF80898"/>
        <property type="gene ID" value="B6264_20045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35696">
        <property type="protein sequence ID" value="OEV35696"/>
        <property type="gene ID" value="HS99_0007270"/>
    </dbReference>
    <dbReference type="OMA" id="SQWLGTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21087" checksum="15150F99C60C8FE0" modified="2017-01-18" version="1">MTTDAPWLIAGLGNPGPWFRLTRHNAGFLAVDRLAERYGARFRRRGIGAVVAEIEVDGRQVLLAKPLWWSINLSGRPVAALLRRYGVPVERLVVVQDDLDFAYGTGKLKRGGGPGGHNGVRSVGEVLGTRDFVRLRFGIGRPPKGQSVGDYVLKKFSDGELAAMPQVTDRCADALETLVRLGLNRAQDALNVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F8</accession>
    <name>A0A1E7N5F8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="12" type="ORF">HS99_0008710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553638.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7310"/>
    <dbReference type="EnsemblBacteria" id="ARF81138">
        <property type="protein sequence ID" value="ARF81138"/>
        <property type="gene ID" value="B6264_21485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35925">
        <property type="protein sequence ID" value="OEV35925"/>
        <property type="gene ID" value="HS99_0008710"/>
    </dbReference>
    <dbReference type="OMA" id="MVEQPGV"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02145">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1328" mass="135102" checksum="7B91D57DDC7C2BD2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5W2</accession>
    <name>A0A1E7N5W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4958"/>
    <dbReference type="EnsemblBacteria" id="ARF80026">
        <property type="protein sequence ID" value="ARF80026"/>
        <property type="gene ID" value="B6264_14890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36082">
        <property type="protein sequence ID" value="OEV36082"/>
        <property type="gene ID" value="HS99_0030910"/>
    </dbReference>
    <dbReference type="OMA" id="ERKFDGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="26047" checksum="745055D88FFC1D64" modified="2017-01-18" version="1">MTEQKVAVVTGASSGIGAATARRLADEGFEVVLTARRTERIEALAKEIGERGGSARAVTLDVTDRAAVDAFAAEVGRVDVLVNNAGGAIGAESVEHGDPADWRAMYEVNVLGVLHVTQALLPALRATGDGTVLVLSSTAALAAYEGGGGYVAAKHAAHTIAATLRLELCGEPIRVIEIAPGMVKSEGFAVTRFRGDEEKAAAVYAGVAEPLTSEDIADTVAWAVTRPSHVNIDLLVVRPRAQAANHKVHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6D9</accession>
    <name>A0A1E7N6D9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type cytochrome biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8059"/>
    <dbReference type="EnsemblBacteria" id="ARF79826">
        <property type="protein sequence ID" value="ARF79826"/>
        <property type="gene ID" value="B6264_13760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36214">
        <property type="protein sequence ID" value="OEV36214"/>
        <property type="gene ID" value="HS99_0030705"/>
    </dbReference>
    <dbReference type="OMA" id="WIAYAAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="42924" checksum="19370A898DDD38B6" modified="2017-01-18" version="1">MHLASGVDPQLADLSNKLIYSAMAVYTIAMFAHMFEWTFGSKGAVAVRSKEQSGNLAETVAAAETKAAKKVTVTVAGAKGGTTTLTRTVLAGEGATVVTGGRTDEDVDGPGAAGTSEKADLAGRIAISLTVLALLLHGGGIVARGLSVSRWPWGNMYEFSCAFAFAMTAAYVVLLAARKNVRWLGLPVTVAVLLTLGIATQVLYTDSEQLVPALHSYWLAIHVSTAIFCGGAFYAAFISTLLYLVQDSYRQRADEGKYEFLRPGALRSHDGQKYSQTRIALARIRVSVCNRLPAASTFDKLSYRINALVFPLWTFTIIAGAIWAEAAWGKYWEWDPKETWSFITWVAYACYLHARATAGWKGRKAAYLALAAFACWLFNYYGVNIFVTGKHSYAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E6</accession>
    <name>A0A1E7N6E6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386058.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8087"/>
    <dbReference type="EnsemblBacteria" id="ARF82817">
        <property type="protein sequence ID" value="ARF82817"/>
        <property type="gene ID" value="B6264_13620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36249">
        <property type="protein sequence ID" value="OEV36249"/>
        <property type="gene ID" value="HS99_0030565"/>
    </dbReference>
    <dbReference type="OMA" id="DSARMMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014298">
        <property type="entry name" value="RNA_pol_sigma-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02952">
        <property type="entry name" value="Sig70_famx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="30030" checksum="AEB8CA1E5FFE0B46" modified="2017-01-18" version="1">MRPRTGLGGRPTAERQISTGLDLLRTLLRSQLAASPQLVPAGVPFGHQHGPGLALRTTAAGSTGTGSRGRTGTTGIGRSRARTAPSPGFETEHNPIMELVERAQAGESEAFGRLYDHYADTVYRYIYYRVGSRATAEDLTSETFLRALRRIGTFTWQGRDFGAWLVTIARNLVADHFKSSRFRLEVTTGEMLDSNECERSPEESVLESLSNAALLDAVRRLNPQQQECVTLRFLQGLSVAETARIMGKNEGAIKTLQYRAVRTLARLLPPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6U5</accession>
    <name>A0A1E7N6U5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386685.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000461.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7800"/>
    <dbReference type="EnsemblBacteria" id="ARF82270">
        <property type="protein sequence ID" value="ARF82270"/>
        <property type="gene ID" value="B6264_28390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36426">
        <property type="protein sequence ID" value="OEV36426"/>
        <property type="gene ID" value="HS99_0029225"/>
    </dbReference>
    <dbReference type="OMA" id="NLSAIWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="162"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="413" mass="44101" checksum="F69F64A86868F0B3" modified="2017-01-18" version="1">MQRASSRTVTVDLTHGEEYFGQLGPFEADLGWWSSVDGVVARATELAGAPVLVTRLVDGHSEDPGHGGRVRYHAEALRRPTALEPRPLDGGTAALLAPADRRAAWATPEGLRAALAWADTQLGAIGRPAGAAARQIRTWNLSALFRLSTAAGTDAWLKTTSPRFNALEGEVIALLGAADPSLVPTVLAADPAHGRLLLDHVPGEDCWSPSTGTVADVVPRFVAAQAALAARPGALAGLRDRTPAALHAQFLALLDRLPAETDLTAAEQDRLRDFAAELPALLDGLAACGLPETLLHGDFHPGNWRTNDGSPVVVDYADACLGHPALDGLRPRAYLTPEAWQHAAVVWTAAWREHAPGSDPRRALELAEPLYHLSYALRYQEFLDHIEPSERPYHEGDPAAELRAVLAPGVSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N724</accession>
    <name>A0A1E7N724_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7798"/>
    <dbReference type="EnsemblBacteria" id="OEV36475">
        <property type="protein sequence ID" value="OEV36475"/>
        <property type="gene ID" value="HS99_0029215"/>
    </dbReference>
    <dbReference type="OMA" id="LEGQWNR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18476" checksum="D150C65D463EFED6" modified="2017-01-18" version="1">MAGTTGTTEASGSTGTTDTTGTTDTTGATDTTGATDTTGNTGTTEAPGTTGTTGTGGGPDEAGDRTIRAEEGEVPDQSDEGRSADREPLLPAAETQELRERWQQVQTDFVDDPRQAVHTADALVADLMQRLAASFADRRSSLEGQWNRGDEVETEELRVALQQYRTFFNRLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E9</accession>
    <name>A0A1E7N7E9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7772"/>
    <dbReference type="EnsemblBacteria" id="OEV36620">
        <property type="protein sequence ID" value="OEV36620"/>
        <property type="gene ID" value="HS99_0027980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="36067" checksum="2767BF4FF053E13E" modified="2017-01-18" version="1">MAHVDEEIASQPECWQRALELTPRHLPEPGERAAVIGCGTSLYIAQAYAALRESLGLGETDAFAASEFPADRRYDRVVALTRSGTTTEVLDALARVGTTETVAVTADPRTPVGAAARHLVALEFADEKSVVQTRFATTALALLRAHLGAAPADLPAQARAALDAPLPRGALEARQFTFLGAGWSCGVAPGRPASRRRPLRRRRWRGGGAGWKGRGGPAGGRRRGAQGWSGGLDGGEPVAADDPAAPAHDGDRVVARGVDHDEVGEAPDRVMRSVTVRASSVSAMSSVMRSRACACSKRHESKQLYAGIPGRRPERPGNGRGRAHSRRSSARAELHSVHAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T0</accession>
    <name>A0A1E7N7T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366332.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4743"/>
    <dbReference type="EnsemblBacteria" id="OEV36728">
        <property type="protein sequence ID" value="OEV36728"/>
        <property type="gene ID" value="HS99_0027270"/>
    </dbReference>
    <dbReference type="OMA" id="VMDLYPC"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="511"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="598" mass="62797" checksum="70A6210A5FF77366" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N810</accession>
    <name>A0A1E7N810_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1429"/>
    <dbReference type="EnsemblBacteria" id="OEV36603">
        <property type="protein sequence ID" value="OEV36603"/>
        <property type="gene ID" value="HS99_0028910"/>
    </dbReference>
    <dbReference type="OMA" id="GVADWMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198858" evidence="1">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="44954" checksum="12C71603DF6255E2" modified="2017-01-18" version="1">MRVLGTALAGALVLTTVSACGGQSGGPVTLKLVAADYGENAETSSKHYWDEVSKAFEAANPGIKVQVEVDSWTDIGKKVDDMIAAGKTPDLLQTGGFADQVAADRLYPAADVLSMDTQAKFMDNFSHAGQVLGTQYGIPFVSSSRVLFYNKAIFRQAGITQPPTTWNELRATAEKIKAKVPGVTPYGLPLGPEEAPAESMLWTLSGGGSLSDDVGNYTIDSDQNQATFSWLKNNLVSTGLTYPDPGKMNRTPAFQDFTAGKVAMLNGHPTLLRMASAANIEFGTAAIPKKDGVGRTGSLGVADWMMAFKANGHKNEIKKFLSFVYTKDYQLKFDEQYNLLPVTQDAFNQMSSDPKHADLKQFAVGLTNASFYPFGDPVWGEVSNRIKAGIGQAVTGDPKQVLGGLQDAAMKEAARVRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N899</accession>
    <name>A0A1E7N899_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553742.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78641">
        <property type="protein sequence ID" value="ARF78641"/>
        <property type="gene ID" value="B6264_06690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36912">
        <property type="protein sequence ID" value="OEV36912"/>
        <property type="gene ID" value="HS99_0027000"/>
    </dbReference>
    <dbReference type="OMA" id="ISAMETC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="29601" checksum="C3281688A1019823" modified="2017-01-18" version="1">MSWKYCGDQLKRWREKAGVTREQLSQAACYDIESVRSMEAGRRKPSLKLLQVADELCDAKGMLVGAAEFLKPEKFPSFSQDFMKYEPEAIVLSSYESQLIPGLLQTEAIARSLLNAHWPPLDDDTVEERVSARLARQAILGKQTKSFSFLIDEFALLRRFGTAPEHKEQLRHLLDASKPRHIDIQVVPARCVHPGVNGAFVLLETADHERFAYEEGQSMGFLYAEPEKVNLLWQRHAMILRQALSPEESARFISKLAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8B9</accession>
    <name>A0A1E7N8B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0027105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6829"/>
    <dbReference type="EnsemblBacteria" id="ARF78622">
        <property type="protein sequence ID" value="ARF78622"/>
        <property type="gene ID" value="B6264_06585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36932">
        <property type="protein sequence ID" value="OEV36932"/>
        <property type="gene ID" value="HS99_0027105"/>
    </dbReference>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="7">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="22725" checksum="BC38AE87B259494C" modified="2017-01-18" version="1">MTSQIFPSDVQQSLDLAGIFVFALSGGLLAVRKNMDIFGICVLAEATALGGGVIRDLVIGATPVAAFSNFGYFVTPLAAALVVFFLHPEVERINRAVQTLDALGLGLFCVTGTAKAHDYGLGAVAAIALGMVTAAGGGVIRDVLAGEIPSLLRWDREIYAVPALVGAALVAALIGANRLTGATGTAAALTAFGLRMLALRYGWRAPRAWHRNGSRTSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L1</accession>
    <name>A0A1E7N8L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81703">
        <property type="protein sequence ID" value="ARF81703"/>
        <property type="gene ID" value="B6264_24890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37022">
        <property type="protein sequence ID" value="OEV37022"/>
        <property type="gene ID" value="HS99_0004110"/>
    </dbReference>
    <dbReference type="OMA" id="WIEDHRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046003">
        <property type="entry name" value="DUF5959"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19384">
        <property type="entry name" value="DUF5959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="15193" checksum="B19A7B55DED82978" modified="2017-01-18" version="1">MMDDALDDLIYLADPPGTSGHVVALRVLQRPDPGGGFLECEFVVSTETVSGNFRVGISAFDLDMWEEALDSLAGNRFVSWLNSGRTVQLKIKPLSPRAIGVSISDDPSSQVTVSLPMSPPAGWIEDHRERLVKARQILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X4</accession>
    <name>A0A1E7N8X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386665.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6635"/>
    <dbReference type="EnsemblBacteria" id="ARF81586">
        <property type="protein sequence ID" value="ARF81586"/>
        <property type="gene ID" value="B6264_24160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37147">
        <property type="protein sequence ID" value="OEV37147"/>
        <property type="gene ID" value="HS99_0004830"/>
    </dbReference>
    <dbReference type="OMA" id="TRFCGNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="810" mass="87354" checksum="03C34B1A70931272" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N906</accession>
    <name>A0A1E7N906_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556614.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000238.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6197"/>
    <dbReference type="EnsemblBacteria" id="ARF81556">
        <property type="protein sequence ID" value="ARF81556"/>
        <property type="gene ID" value="B6264_23950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37180">
        <property type="protein sequence ID" value="OEV37180"/>
        <property type="gene ID" value="HS99_0005035"/>
    </dbReference>
    <dbReference type="OMA" id="PVHMRER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="43617" checksum="909B2235C78FB7DD" modified="2017-01-18" version="1">MDSATLLARITDYASRPNPYPLYAELREAGPVVPQADGSYLIGTYHHIAALLHDPRMSADPRTRGEMTHKPPFLRLDDPEHHRLRTLAMRPFGPPHSPGRVDGMRGEIDRITEALLEPFEAGHQVDIVDDFAYPLPVTVICRLLGVPHEDEPLFRAWSDAIVAAADVRPDDESAEPDKGGDQARMELGGYLLNLAEQRRGKPGEDMLSAFVNEPDPALRLTPEELAETAVLLLIAGHETTVNLIANGALTFLRQPEQLDRLRREPELLPRAVEELLRYEPPVHMRERIPHADMDIAGTPVPRGVPVILALASGNRDPQRFPDPDRFDPARQDNQHLGFGSGIHACYGGPLARLEAYAALGALLPHLATASLVQDPPPYRQNAMLRGPRHLPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H3</accession>
    <name>A0A1E7N9H3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556459.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5443"/>
    <dbReference type="EnsemblBacteria" id="OEV37350">
        <property type="protein sequence ID" value="OEV37350"/>
        <property type="gene ID" value="HS99_0006075"/>
    </dbReference>
    <dbReference type="OMA" id="WLTVNVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="51833" checksum="1E5C4F873C215259" modified="2017-01-18" version="1">MLTQPAVHTTGGSVRGLLDRGLAVFRGIPYAQPPVGQLRFAAPLQPEPWDGVRDAFEFGPVVPQSGPLPAEPTRGTDWLTLNVCTPDPGAAGLPVLVWIHGGGFISGTSGDPLYDPVGLARAGLVVVSVNYRVGAEGFALLEGAPANRAFLDQVAALEWVQRNIAGFGGDPGRVTIAGQSAGAASVAALLTMRRARGLFRRAVAHSVGGNLSTPALAAEVTAALAKRLGMASTAAALAEGDPWRLAAAVTDLGTALPEHLGRWGRLAQTGVATVPVVDGEVLSEEPWAALAAGRIPGTDLLVGHARDEFRLFSVLAGRHGTFTDDEARTALELLAPHPDGPDAYRAAHPGATAEDLLEAVTSDALFRMPSLHLAEGNAAAGGTSYVFELTYPAPAMGGVLGACHALDIPLAFGTLDTPMGRHFLGDPPGPEAVEVSCELQQAWIRFVSTGDPGWPAYEPTRQLTRMFDSRSETVRYPEQSSRDIWAGHTPTAYDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N5</accession>
    <name>A0A1E7N9N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6177"/>
    <dbReference type="EnsemblBacteria" id="OEV37193">
        <property type="protein sequence ID" value="OEV37193"/>
        <property type="gene ID" value="HS99_0005120"/>
    </dbReference>
    <dbReference type="OMA" id="AGATHRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="35094" checksum="A9E41C09F0FD5E55" modified="2017-01-18" version="1">MVHGMDLRRLRYFVAVAEELHFGRAAARLHMSQPPLSQRIRELENELGCQLFQRSAQGVRLTEAGSVLLGEAKELLDAAERARERVRETGRRRTIVVGTVAGAGLEFGPRAAAAFRRTHPDAQVRLCEADISDPTAGLRSGRVDVALTRLPFDTAGLAVRLLETEPLVAAVPADDPVARRPHLRVGDLLGRPWIRLPEDADAAWRRYWLGEADSGEAVERSAGTGSGPVVRTVSECLHAVVWQGAVGILPAGATHRHRTEGIAFVPLTDYPPSRVVLAWPSEVPDPAVLAFVEAVGARPVPDTDGAPGTAYDLFNRPPDLLNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q5</accession>
    <name>A0A1E7N9Q5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386562.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7420"/>
    <dbReference type="EnsemblBacteria" id="OEV37421">
        <property type="protein sequence ID" value="OEV37421"/>
        <property type="gene ID" value="HS99_0004440"/>
    </dbReference>
    <dbReference type="OMA" id="GRWCHGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="36840" checksum="3FB545C7CD844197" modified="2017-01-18" version="1">MAVARWCAAQGWPVHPLAPGRKTPPANCQPCQESPHSPAECLCPRVGRWCHGFHAATTDQEVISAWWRVNPGFGTGVACGPSGLVVIDVDSHPADVPARDRILPGIPIHDRVDLEGLENGYHTLALLAALRKAPDPSADAGTLRVRTPSGGLHIWYRDDAHHRFTCSTGSSTGRALAWQVDVRAHGGYIVAPSTVTTSGTYRPLPGATVPAPLPRWLAEELIRTGHLKDRPQQPGSPLPAVPDRARQAVVAAGGGRRGAEKVLDTVLQDVTDCATIPEGAGFTGKLNRAAYTVGGLVSAGHLTHAAAERLLTDAARTARPAQDRQSSAVIRSGLEAGARQPLHIGKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q8</accession>
    <name>A0A1E7N9Q8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556658.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37427">
        <property type="protein sequence ID" value="OEV37427"/>
        <property type="gene ID" value="HS99_0004910"/>
    </dbReference>
    <dbReference type="OMA" id="HAGAFLK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="18456" checksum="C8DD4F221F605B6F" modified="2017-01-18" version="1">MLPEITQEEQVELDKALYDALNPLASAIRSRETGLSADRMWDADPVAVALSVLAAWRAVDAEVKRLTANAAATAGSYGASYEQLGAVWGITRQGARKKWPGAITRPALATARPTSLEIFGGTAELVQAPSGGWSWRGEGADGAFGAADDGACYATAEEAAAHAGAFLKEHAADTAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC0</accession>
    <name>A0A1E7NAC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290440.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6243"/>
    <dbReference type="EnsemblBacteria" id="ARF79887">
        <property type="protein sequence ID" value="ARF79887"/>
        <property type="gene ID" value="B6264_14120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37631">
        <property type="protein sequence ID" value="OEV37631"/>
        <property type="gene ID" value="HS99_0025335"/>
    </dbReference>
    <dbReference type="OMA" id="YAMARTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="26392" checksum="35C621DD17034F40" modified="2017-01-18" version="1">MPPALRPAALAAALLLLGAATGCSMLAAPGTQVPGEPAPVPPKQVVLAAAQALDDTGGARIEVVREGPDGRRTASGTLVWGDRDEAALAVTDELGSGRLTLHDGAIDLVYQGAAPKHADRGTAESLDPKAGIDPGGYAGGWMSTLVTNPGSRAYAMARTDRLGSLGGEQLAGVTAAHYRGTVPVADYFGADGELSTQRLAALVDWYRQRGVAQIGYDVWVGPGRRLLRLRETARGSAGTTVTTTDVSVPGAGDTASAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM2</accession>
    <name>A0A1E7NAM2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">HS99_0025665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280803.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1661"/>
    <dbReference type="EnsemblBacteria" id="ARF82833">
        <property type="protein sequence ID" value="ARF82833"/>
        <property type="gene ID" value="B6264_14455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37745">
        <property type="protein sequence ID" value="OEV37745"/>
        <property type="gene ID" value="HS99_0025665"/>
    </dbReference>
    <dbReference type="OMA" id="HWEHSVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="29520" checksum="9DF94A663915636F" modified="2017-01-18" version="1">MVEIKTPEQIAKMRAAGLVVAEALKACRAAVAPGVTTQELNDIADKVITDHGATSNFRAHHGGLWFPGVICASVNNEVVHGIPGDRVLQEGDLISIDCGAILDGWHGDSAITVAVGEVSPEVEMLSRVTEGSMWAGIAQMKKSNRLVDVSKAIEGYIRRQPLPPKGKWGITEGYGGHGIGTAMHMEPHVLNYVERGRGKGPKLVPGTVLAIEPMVSLGTPHTTVLDDDWTVVTNDGTWASHWEHSVAVTEQGPLVLTAFDGGRAELAKLGITAAPDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAX9</accession>
    <name>A0A1E7NAX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0025045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556726.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6008"/>
    <dbReference type="EnsemblBacteria" id="ARF78015">
        <property type="protein sequence ID" value="ARF78015"/>
        <property type="gene ID" value="B6264_02925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37847">
        <property type="protein sequence ID" value="OEV37847"/>
        <property type="gene ID" value="HS99_0025045"/>
    </dbReference>
    <dbReference type="OMA" id="YFLVLRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="28035" checksum="8CEEF0EC9E92E11A" modified="2017-01-18" version="1">MTAVLTQTFFQHALLAGTFIAPACGLVGYFLVLRAQIFTGDALSHVAFTGAMAALAGGYDLRLGLFAATVGVGLLLGGLGRRGRPDDVVIGSVFAWILGLGAFFLTVYTTSRSAARGGAGTSVLFGSIFGLSSGQTTLAVLIAAGICVAVLLIARPLLFATLDEAVAAARGVPTRVLGLAFLALVGACAGEATQAVGSLLLLGLLAAPAGAAIRLTDRPFRALALSAALAVAEMWGSLLLSAEAPELPPSFAIMATASAVYAATFLVRPNRALRTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA6</accession>
    <name>A0A1E7NBA6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein MobA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552078.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2080"/>
    <dbReference type="EnsemblBacteria" id="ARF79487">
        <property type="protein sequence ID" value="ARF79487"/>
        <property type="gene ID" value="B6264_11670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37934">
        <property type="protein sequence ID" value="OEV37934"/>
        <property type="gene ID" value="HS99_0024000"/>
    </dbReference>
    <dbReference type="OMA" id="MARMRDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6457" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9134" checksum="4AC6B7457BBFE351" modified="2017-01-18" version="1">MERTLEDWIAEVKADLGIDLDVDVRGLLDTARVVAHGVARPAAPLTAFLIGYAAAQKGGGPAAVAEASRRTTALAERWQPADGPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD3</accession>
    <name>A0A1E7NBD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0024400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2000"/>
    <dbReference type="EnsemblBacteria" id="ARF79557">
        <property type="protein sequence ID" value="ARF79557"/>
        <property type="gene ID" value="B6264_12085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37999">
        <property type="protein sequence ID" value="OEV37999"/>
        <property type="gene ID" value="HS99_0024400"/>
    </dbReference>
    <dbReference type="OMA" id="GWADTEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="499" mass="54794" checksum="B10A910A4657D6DC" modified="2017-01-18" version="1">MSEDRTPAVAENPEAEGGEEPPQFKGRKNGLYGEISDELSASMKSGWADTELHGLAPIAQAGYAAERRAALSAAHPGVRLVVPAGNLRVRANDTDYNFRAASEYVHLTGDQTEDAVLVGEPTGDAGHEFTLYLLPRSDRENGEFWLDGYGELWVGRRYSLSEQEQRLGLPARDVRKAAEELAERAKGSAVPTRIVRGYDAGLEAALAEVLDADKDAELKEFLSGLRLVKDEWEIGELRAACDATVKGFTDVVRELGQAVATSERWIEGTFWRRARVEGNDVGYGTIAAAGPHATTLHWVRNDGDVRPGELLLLDAGVETHTLYTADVTRTLPINGTFTELQRKIYDAVYDAQEAGIAAVRPGARFRDFHEASQRVLAERLLAWGLLDASVHDVEKVLELGLQRRWTLHGTGHMLGLDVHDCAHSRREEHVDALLVPGMVLTVEPGLYFQQDDLTVPEEYRGIGVRIEDDILVTADGNENLSAGLPRRSEDVEAWMASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD7</accession>
    <name>A0A1E7NBD7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033346907.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1996"/>
    <dbReference type="EnsemblBacteria" id="ARF79561">
        <property type="protein sequence ID" value="ARF79561"/>
        <property type="gene ID" value="B6264_12105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38002">
        <property type="protein sequence ID" value="OEV38002"/>
        <property type="gene ID" value="HS99_0024420"/>
    </dbReference>
    <dbReference type="OMA" id="ACKHGRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="19884" checksum="6AAEF31D9B3DEB94" modified="2017-01-18" version="1">MVAREVPTSSTMAVPHGPSSVGVARRRLRRDLGDRQIPEPVIEDAVLILSELLSNACRYARPLGPLRALGRGARAEVVDQVLVGVPSGTHPAPGGPEREDGPAEPDGGVLVRWQMHADGVLTLEVTDGGAATRPAPASPSLTSRGGRGLGIVDQLASDWGVRDAPGEVTVWAALPARARHARRTGGDARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF0</accession>
    <name>A0A1E7NBF0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551647.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000801.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8145"/>
    <dbReference type="EnsemblBacteria" id="ARF79754">
        <property type="protein sequence ID" value="ARF79754"/>
        <property type="gene ID" value="B6264_13325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38036">
        <property type="protein sequence ID" value="OEV38036"/>
        <property type="gene ID" value="HS99_0022780"/>
    </dbReference>
    <dbReference type="OMA" id="EYRLQWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="31610" checksum="4687E44634A484CF" modified="2017-01-18" version="1">MAPPTPLRRRPGAVPAAALATLAALTVLGVLAFGHPAPGGLRDDGPRVAVTPPTSAKPLWPGLATAPPPATSATGSSTQAPPPQPVPDLTAPGHDLTAVDLHTLLAKDPAVSAEERRALDSCTGCEVRAPEFRDLTGDGLPELIAAVATPGQVALHVYTLTGDRVLPILRVQIKPDFGAATLDSDLWLYEPTTVTTRTTSHYQWDGTRLALVEKRVDGIGLLPPTDPGTDPPTGTGAVGAVPGPVRPSAEARPGAGAAVPTARPGRPQPQPAQPSQRYQPTPQYQQSSQYQSSQPSAPAVVPEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBH8</accession>
    <name>A0A1E7NBH8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">HS99_0022860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288536.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000553.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3052"/>
    <dbReference type="EnsemblBacteria" id="ARF79740">
        <property type="protein sequence ID" value="ARF79740"/>
        <property type="gene ID" value="B6264_13245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38050">
        <property type="protein sequence ID" value="OEV38050"/>
        <property type="gene ID" value="HS99_0022860"/>
    </dbReference>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="25356" checksum="98A31F6EF7CD2357" modified="2017-01-18" version="1">MNASGAVAAAVVPAAGRGERLGPGAPKALRELGGVPLLVHAVRALARSRAVGLVVVAAPADGVAEVVALLDSHGLDDKDIRVVAGGATRQESVRLGLAAIPEEVGIVLVHDAARPLVPVEVVDAVAAAVRAGCGAVVPAVPLADTVKRVEPNPGGPEPVVDTPERATLRAVQTPQGFDRATLVEVHAKALAEETAGGVAAPPVTDDAGLVERYGGTVVVVPGHEEAFKVTRPLDLVLAEAVLARRRAADAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBI1</accession>
    <name>A0A1E7NBI1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="9" type="ORF">HS99_0022855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288537.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000553.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3053"/>
    <dbReference type="EnsemblBacteria" id="ARF79741">
        <property type="protein sequence ID" value="ARF79741"/>
        <property type="gene ID" value="B6264_13250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38049">
        <property type="protein sequence ID" value="OEV38049"/>
        <property type="gene ID" value="HS99_0022855"/>
    </dbReference>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="16548" checksum="628EB13C36A1237D" modified="2017-01-18" version="1">MPTEPLIPRVGIGTDVHAFEAGRPLWVAGLEWPDAEFGLAGHSDADVAAHASCDALFSAAGIGDLGAHFGTDRPEWAGASGVKLLGEAARLVRAAGFEIGNVAVQVIGVRPKIGKRRAEAQAALSEAVGAPVSVSGTTTDGLGLTGRAEGLAAIATALVYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBL8</accession>
    <name>A0A1E7NBL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7573"/>
    <dbReference type="REBASE" id="196752">
        <property type="entry name" value="SauDM1ORF3285P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82592">
        <property type="protein sequence ID" value="ARF82592"/>
        <property type="gene ID" value="B6264_03285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37863">
        <property type="protein sequence ID" value="OEV37863"/>
        <property type="gene ID" value="HS99_0024710"/>
    </dbReference>
    <dbReference type="OMA" id="FALEAKC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041409">
        <property type="entry name" value="RE_AspBHI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18062">
        <property type="entry name" value="RE_AspBHI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="45148" checksum="7AD326E7A7881D1C" modified="2017-01-18" version="1">MPAPNAPVAVPGKPAVGFTHLQDADLQVDALYLGGTNGNTGDDPIAKLLRGVGNQGGFRYVGSPLRGDVRLVVLYTTGDQPDWPDALDPQTGAFTYYGDNRTPGHELHGTSRKGNLLLRDIFAASHETPEQRRRIPPFLLFEKAAAKGRDVRFRGLLAPGGPALTSDDELAAVWRTTAGRRFQNYRARFTVLNQAVVSRGWIDHLRSGGDPLSGGCPSAWRTWVHTRSYSPLTAPVTTLIRSQADQLPADREGQAVLEAIREHFRGREHDFEACAVALWRLLAPATGQVDITRRSRDGGRDAIGKYHLGPPADRIAIDFALEAKLYKPSNSVGIREGSRLISRLRHRNFGVLVTTSHFNGQFQEEVRNDGHPIILVCGRDIVELLRQHGYTTSDAVLSWLIHQFPSPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY0</accession>
    <name>A0A1E7NBY0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386771.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3297"/>
    <dbReference type="EnsemblBacteria" id="ARF80284">
        <property type="protein sequence ID" value="ARF80284"/>
        <property type="gene ID" value="B6264_16430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38206">
        <property type="protein sequence ID" value="OEV38206"/>
        <property type="gene ID" value="HS99_0021850"/>
    </dbReference>
    <dbReference type="OMA" id="WTLLDHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="43700" checksum="E138B3D3B20AAA58" modified="2017-01-18" version="1">MNVSTNVPLGGHAEPLAQRLAELRGPAPQRSLNARSLAALAANPGCRRRAVLDAAGVDKSVLAARLGRPAPFGQSPFAIARGLVFESRLKADGYAALLEPLRAHLGVPADDRAPLLVPDLLHRSGPAVRADRTAEALARAAADPDAWTLLDHPMLRLAVAGSTAYLEPDALVVHGGRCTVVEIKSFPVLDGGADPAKVGAAARQAAVYVLALQHAAAAAAGLPLADDPYTEQRLPGSPRTSVLLVCPKDFGNRPTAVAVDVRRELATTRRQLSRMTGIGRLLAALPPGTDFDLATDEDGAPARSTEQLTAAVEAVPAAYSPDCLSTCELGFHCRARARCDDRVEQLGRGVRGELGSIRTVAEALAAASGAGTPDTAALDADDTDGAHEAAERLAYAAALRAEALGTGHPGADRLGTERNPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC08</accession>
    <name>A0A1E7NC08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000369.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3323"/>
    <dbReference type="EnsemblBacteria" id="OEV38229">
        <property type="protein sequence ID" value="OEV38229"/>
        <property type="gene ID" value="HS99_0021995"/>
    </dbReference>
    <dbReference type="OMA" id="LAREHWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="24585" checksum="31A164A5A0179B27" modified="2017-01-18" version="1">MTPYQSPSPGDSRPLAEELLLLCAEPTRGLLRIPGTTFPTAITGAVLAELQLRGAITVEGRRITGFHPLGDHDELAARVLAELERAGKNQHRATLDHVLRRVPHRTDPQYYLDRLTGQGVLTVRTHRFLGLPYRRWTAVPPDAGALIAERVAATLARTAVSGPTSPAEERDHQLAGLIGAVRLEYRIYRGTAGTPTRRAVRRLSRSLPVAHAVKQAVARRTAAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF3</accession>
    <name>A0A1E7NCF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366391.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000516.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38371">
        <property type="protein sequence ID" value="OEV38371"/>
        <property type="gene ID" value="HS99_0020865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13734" checksum="73F8D29E0D516B68" modified="2017-01-18" version="1">MADLGGRPADGADSGDDVLVLKPKLANIRQSGRWTVPSRIVAECRMMHIEIDFTEAVCPHREVTVEATCGAGHIRLVVPAGWGVRVDGSSTNTGHIVNKATEAAEPGAPTVTVVGHPRSGLIKIKQRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM9</accession>
    <name>A0A1E7NCM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Salicylyl-CoA 5-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0021390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385929.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene335"/>
    <dbReference type="EnsemblBacteria" id="OEV38456">
        <property type="protein sequence ID" value="OEV38456"/>
        <property type="gene ID" value="HS99_0021390"/>
    </dbReference>
    <dbReference type="OMA" id="PMFTPFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="123"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="403"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="792" mass="84860" checksum="96A230CF204A21B9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND53</accession>
    <name>A0A1E7ND53_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551498.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000654.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene659"/>
    <dbReference type="EnsemblBacteria" id="ARF77604">
        <property type="protein sequence ID" value="ARF77604"/>
        <property type="gene ID" value="B6264_00505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38578">
        <property type="protein sequence ID" value="OEV38578"/>
        <property type="gene ID" value="HS99_0020090"/>
    </dbReference>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26035" checksum="E854515E2411D8EA" modified="2017-01-18" version="1">MTEQSTAPRVAVVTGAARGLGAATAVRLAADGYAVAVLDLDEAAGKDTVDRITAAGGRALAVGADVSDAEQVQAAVDRVVAELGAPVVLVNNAGVLRDNLLFKMSESDWDTVMNVHLRGAFLMTRAVQKHMVDAGFGRIVNLSSSSAQGNRGQANYSAAKAGLQGFTKTLAIELGKFGITANAVAPGFIATDMTAATAARVGVDFEDFKRAAASQIPVQRVGEPEDVANTISFLAGEGAGFVSGQVIYVAGGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI0</accession>
    <name>A0A1E7NDI0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="5" type="ORF">HS99_0018925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286348.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7336"/>
    <dbReference type="EnsemblBacteria" id="ARF81159">
        <property type="protein sequence ID" value="ARF81159"/>
        <property type="gene ID" value="B6264_21655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38750">
        <property type="protein sequence ID" value="OEV38750"/>
        <property type="gene ID" value="HS99_0018925"/>
    </dbReference>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32261" checksum="6E5D36E4AA1DF74B" modified="2017-01-18" version="1">MSTTPTTADQPQIGTARVKRGMAEQLKGGVIMDVVNAEQAKIAEDAGAVAVMALERVPADIRKDGGVARMSDPNMIEEIIEAVSIPVMAKSRIGHFVEAQVLQSLGVDYIDESEVLTPADEVNHSDKWAFTTPFVCGATNLGEALRRIAEGAAMIRSKGEAGTGNVVEAVRHLRQIKNEIGHLRALDHNELYAAAKELRAPYELVKEVAELGKLPVVLFSAGGVATPADAALMRQLGAEGVFVGSGIFKSGDPAKRAAAIVKATTFFDDPKIIADASRNLGEAMVGINCDTLPETERYANRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDS7</accession>
    <name>A0A1E7NDS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556364.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5143"/>
    <dbReference type="EnsemblBacteria" id="ARF81265">
        <property type="protein sequence ID" value="ARF81265"/>
        <property type="gene ID" value="B6264_22290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38861">
        <property type="protein sequence ID" value="OEV38861"/>
        <property type="gene ID" value="HS99_0019555"/>
    </dbReference>
    <dbReference type="OMA" id="IHYDIPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="949" mass="106025" checksum="1985CB0DAB6CCDF9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDY5</accession>
    <name>A0A1E7NDY5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290511.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6521"/>
    <dbReference type="EnsemblBacteria" id="ARF81292">
        <property type="protein sequence ID" value="ARF81292"/>
        <property type="gene ID" value="B6264_22445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38884">
        <property type="protein sequence ID" value="OEV38884"/>
        <property type="gene ID" value="HS99_0019710"/>
    </dbReference>
    <dbReference type="OMA" id="CSPAGHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="10141" checksum="B04BAE0633389CF6" modified="2017-01-18" version="1">MSETTVTVESSSTGGSCCGSCGTGAGKAPATAAAERAVFQVKGMTCGHCVSSVTAELEKVAGVTEVAVDLATGQVTVDSTAPLADTDVAAAIDEAGYALIGRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE06</accession>
    <name>A0A1E7NE06_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555417.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000546.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6498"/>
    <dbReference type="EnsemblBacteria" id="ARF81273">
        <property type="protein sequence ID" value="ARF81273"/>
        <property type="gene ID" value="B6264_22330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38868">
        <property type="protein sequence ID" value="OEV38868"/>
        <property type="gene ID" value="HS99_0019595"/>
    </dbReference>
    <dbReference type="OMA" id="SWGQLYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="56988" checksum="935A9A9F0790DEE2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE47</accession>
    <name>A0A1E7NE47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83167">
        <property type="protein sequence ID" value="ARF83167"/>
        <property type="gene ID" value="B6264_29925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38944">
        <property type="protein sequence ID" value="OEV38944"/>
        <property type="gene ID" value="HS99_0017670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="468" mass="49674" checksum="CF1302005B467460" modified="2017-01-18" version="1">MALFDLDGGQAEGARCEGPGCENTLPPRTGRGRRPVYCSQACKSRADRARVKARAAAVPPGPVAPDSAEAASGERTGGKRPASGLSVERQRVLGAADAIRDRAEAFLAAVDDDPLAAHAELARRVHGLASLLITSAREVRDQVRWPGLDADARTAARIREEWNLPDPDPNTDRGDFLVPSSPLPGTGEAHRGEKDSGAVPNPPAPKTPRDETGAAADEHAPLRSAVADPLSRFGRPDRHHDLSITFGQGWQLATWDSPQAGGARLLVRAGVPIGWTTLLPQGPWGLGGWIAVEHQGPGKPGRVVVGTLGRPQTFATADLALDVFHQSSRHLADAVPPRTPATAVRTPAAPMPNLTLGQTTSRTAPTERALGQAHRDYALDDGLVHLTWPTAPHIQALERRGRLLGWTEVYDDNTSWITLINGHPIADAADNLPLLSTNPTDALTLLRLAVERGLSGIAPGWVLPRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE73</accession>
    <name>A0A1E7NE73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385786.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83198">
        <property type="protein sequence ID" value="ARF83198"/>
        <property type="gene ID" value="B6264_30100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38972">
        <property type="protein sequence ID" value="OEV38972"/>
        <property type="gene ID" value="HS99_0017840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8599" checksum="4F6150CCF8D4D44C" modified="2017-01-18" version="1">MTSTQPLPRGISALIPNAHAQATPGELAAAQLLHLRSATVPVPVLAAAAALIAAQLEDPDPATREAAVAVHARLLAAIEDAEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA0</accession>
    <name>A0A1E7NEA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557532.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1037"/>
    <dbReference type="EnsemblBacteria" id="ARF83262">
        <property type="protein sequence ID" value="ARF83262"/>
        <property type="gene ID" value="B6264_30450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39031">
        <property type="protein sequence ID" value="OEV39031"/>
        <property type="gene ID" value="HS99_0018180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8757" checksum="29881865FEA9EAFA" modified="2017-01-18" version="1">MVSNNSQIVPPGMPASSVNLLPGVDGTRHKTGLSVLNQLLLDVLAPLDGVQDVALCGNGFLPPASLHGPFLYSDHPKMAEAANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV9</accession>
    <name>A0A1E7NEV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1044"/>
    <dbReference type="EnsemblBacteria" id="ARF83254">
        <property type="protein sequence ID" value="ARF83254"/>
        <property type="gene ID" value="B6264_30405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39023">
        <property type="protein sequence ID" value="OEV39023"/>
        <property type="gene ID" value="HS99_0018135"/>
    </dbReference>
    <dbReference type="OMA" id="KVSPGCK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="36141" checksum="B7D581008F11D14B" modified="2017-01-18" version="1">MSTGTRIEWTEATWNPATGCDRVSAGCDNCYALTLARRLKAMGSPKYQADGNPATSGPGFAVTVHPDALDEPLRWRRPRRVFVNSMGDLFHPRVPDEFIAKVFAVMARTPQHTYQVLTKRHDRLRALLSRAAFRETAAPGTAWPLPNVWVGVSVEDQHWAEIRVPALLATPAAVRFVSCEPLLGPVDLTRIPYQGDRDYVLDALDGRYGEREPRTLFSAGLAGLGQIDWVIAGGESGPGARPMHPAWARSLRDQCTNTRRPVPFFFKQWGGWAPSGYVGIGNTQPNHVLIGDPVDDLGHREKLVRVGKKAAGRELDGRTWDEYPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ6</accession>
    <name>A0A1E7NEZ6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0225 protein HS99_0000285</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0225 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829886.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3520"/>
    <dbReference type="EnsemblBacteria" id="OEV39205">
        <property type="protein sequence ID" value="OEV39205"/>
        <property type="gene ID" value="HS99_0000285"/>
    </dbReference>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199163" description="UPF0225 protein HS99_0000285" evidence="4">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16032" checksum="15049479162DBC70" modified="2017-01-18" version="1">MDGMSRRRSAPRPAVPRLLPSSPCPCGSSAAYGDCCGRLHRGQAKATTAESLMRSRFSAFAAQDEAYLLRTWHPDTRPAEVDFDPALRWTRLEVVSTSEGGAFHAQGTVAFRAHWTEGGEEGVLTEHSRFVRHEGAWVYLDALSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF27</accession>
    <name>A0A1E7NF27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3638"/>
    <dbReference type="EnsemblBacteria" id="OEV39297">
        <property type="protein sequence ID" value="OEV39297"/>
        <property type="gene ID" value="HS99_0000860"/>
    </dbReference>
    <dbReference type="OMA" id="WRNLHGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="223"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="36915" checksum="956543A3C9503DAD" modified="2017-01-18" version="1">MATVFRGEELPAEERFDCWRELLERTRACDATSAHAGDFRAELRRSELGEVVLLGTSFPSVRFRRTERMVRRSDEGVLHLSFLQEGTMTLTRGAGRTETLRPGDLHLVDSSTPYDLRTFGGPTAGRAEPRVSGVGIDFPAALLPLPPHRLRGLLGRAFSARAGSAALLSEFLLGLDRQAAALGPAEAARLGTVVLDLVAAWLARELDAEGAVPDDTRQRALVEGVRAFVRRNLHDPELSPATIAAAHHVSVSHLHRVFTRQSAGETVAAWIRGQRLERARRDLADPAQRATPIHAVAARWGIPRADDFSRSFRAAYGLPPREYRHRELAAIAGQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF34</accession>
    <name>A0A1E7NF34_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386752.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3621"/>
    <dbReference type="EnsemblBacteria" id="OEV39284">
        <property type="protein sequence ID" value="OEV39284"/>
        <property type="gene ID" value="HS99_0000780"/>
    </dbReference>
    <dbReference type="OMA" id="EMSRMYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199077" description="Histidine kinase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="4">
        <location>
            <begin position="331"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="518"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="864" mass="91480" checksum="8C6B5FB8DA0D3D21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF5</accession>
    <name>A0A1E7NFF5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1555"/>
    <dbReference type="EnsemblBacteria" id="OEV39378">
        <property type="protein sequence ID" value="OEV39378"/>
        <property type="gene ID" value="HS99_0001330"/>
    </dbReference>
    <dbReference type="OMA" id="LARCGPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16660" checksum="744472A1799C4F2B" modified="2017-01-18" version="1">MSADGGGLSAEAVVRLRLAIGRLNRQLVRASGDQDLTSAQLSALARVEQHGPLRLGELAAREGVAVPSMVRTVAPLVADGLIAKTPDPQDGRSQLLAPTGHGRDTLARIRRERTALLARRSTRLSPEQCRALEAALPLLELLLDESDTPARQRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG4</accession>
    <name>A0A1E7NFG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288801.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1569"/>
    <dbReference type="EnsemblBacteria" id="OEV39388">
        <property type="protein sequence ID" value="OEV39388"/>
        <property type="gene ID" value="HS99_0001400"/>
    </dbReference>
    <dbReference type="OMA" id="VPDLTCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199084" evidence="2">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22577" checksum="8BB7FFE5148392B9" modified="2017-01-18" version="1">MSWRTLTRTAAVAATVAALAAGTAAAAPVPAPSSARHDGNPEPASHSWPQRLLDRSPDLVQPKSLTVDRSIGARRAAQEVRLAQQLYTFWNTGRQRYLDAAISPQFRDNTLPPGRPQGPAGPLAASKTFRAAVPDLTCELSDVLVTGDRITARLVFRGHFTGTFNGVRGEGQSVEFNAIDIQHVGTDRIVEDWHIEDNQTLLTQLGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI6</accession>
    <name>A0A1E7NFI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285899.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5099"/>
    <dbReference type="EnsemblBacteria" id="OEV39470">
        <property type="protein sequence ID" value="OEV39470"/>
        <property type="gene ID" value="HS99_0001885"/>
    </dbReference>
    <dbReference type="OMA" id="GRTHRMK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30018" checksum="3B3B37025CC78ABB" modified="2017-01-18" version="1">MNDTTKVALAAAVVGGYVLGRAKKGRLAFAAATYLAGRRFGLDPRQLATEGIRKLAEVPQVAELNKQVRGELLETGKKAVAAAADRRIGELADSLRERTLNIGKPKRDEGQDEEEPYEAEAGEEEWDEEPEEEEEPDQAGEEDEYEEEPEEEEEPEEEEEPEETRPAKPARRRRTAEPAGDQPRSSRTAPSTSAPKTAARRPVRKAAPAGKKTTAKSPPAAKKSSARATTSKTAASKPAREKAPTPAKKTAAKKTAAKRTAASKSTAAKPSTRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFR9</accession>
    <name>A0A1E7NFR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285893.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5093"/>
    <dbReference type="EnsemblBacteria" id="OEV39475">
        <property type="protein sequence ID" value="OEV39475"/>
        <property type="gene ID" value="HS99_0001915"/>
    </dbReference>
    <dbReference type="OMA" id="WPPYHFV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009430">
        <property type="entry name" value="Gas-vesicle_GvpL/GvpF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36852">
        <property type="entry name" value="PTHR36852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06386">
        <property type="entry name" value="GvpL_GvpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="29501" checksum="93041817DCAA121F" modified="2017-01-18" version="1">MSDASLTYAYAVARDRTPALAAEAGTLTGVAGAPVRLLTPDRTTTPVAVVSHVPAEDFHEAALHRHLEDLGWLEALARAHHGVIEALAAHTTVLPLRLATVYLDDDRVRAMLDDNQKLFFDGLERLRGHVELGVKLYVEAEPRPPAATDAPPDPALSPGRAYLRRRRTEQDARHDAHRAAEEAAQRIAVIARAHAVQWARHRVQEGELATGPGQNVVNDAYLVPADHVRAFREETMHATDGLPGLRVDVTGPWAPYSFATLTPPEPGTASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV2</accession>
    <name>A0A1E7NFV2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6708"/>
    <dbReference type="EnsemblBacteria" id="OEV39581">
        <property type="protein sequence ID" value="OEV39581"/>
        <property type="gene ID" value="HS99_0002565"/>
    </dbReference>
    <dbReference type="OMA" id="CVDLHKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="49386" checksum="86B63C7A1800DDC0" modified="2017-01-18" version="1">MHPDLASDLDQLPALLEEARQRAVGFLAGLDDRPVIPRQADRPTPAGPLQENGGGLRAALAEFDERWEPRLSASTGPRYFGFVTGGATPAALVGDWLTATADQNSNSSLDPAGQHLERETVGWLRELFGLSSAHSGAFVSGATMSNTVGLAVAREWLGERLGVDVAEDGVAALGRVRVLSGSAHSSVSKALSVLGLGRAALTVVPTLPGREAVDVAALERALAEADGPCIVVANAGTVNTVDFDDLSAIAALREQYGFWLHVDAAFGAFAALSPEHARLVAGLDRADSVCVDLHKWLNVPYDSAVQFTRRRDLQARVFQNAAAYLGPIGEHPDLVHLTPENSHRLRALAAWFTLRAYGRAGHREIVERCTTGARALGEAIEAIDGLRLLAPVRLNVVCFTLAEDPTPERLAALAAELSGEAFLTPTRYAGLPALRAAFSNWRTTEADVRRTAEALAGAVRKLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW0</accession>
    <name>A0A1E7NFW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555568.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6696"/>
    <dbReference type="EnsemblBacteria" id="OEV39590">
        <property type="protein sequence ID" value="OEV39590"/>
        <property type="gene ID" value="HS99_0002630"/>
    </dbReference>
    <dbReference type="OMA" id="ECPEEPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12690" checksum="5FC1340AB0904E3A" modified="2017-01-18" version="1">MPLVDVTHAPTVPESSLRELGSVLPHLVSLAVECPEEPYDGDLRPGDVEIRFRSLGPLDRSGLAVVIEIKSKWFASREANRQERVDALHESIRAATGLVDFGVYLSLPIAAWSQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG31</accession>
    <name>A0A1E7NG31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558311.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3123"/>
    <dbReference type="EnsemblBacteria" id="OEV39453">
        <property type="protein sequence ID" value="OEV39453"/>
        <property type="gene ID" value="HS99_0001770"/>
    </dbReference>
    <dbReference type="OMA" id="ARIHHYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8595" checksum="3A53EC26FDBCC5BC" modified="2017-01-18" version="1">MKAAVGDRIIVQGTRPGAARRDGEIVGLHHPDGSPPYDVRWSDDNRVTEYFPGPDARIHHFDHEHAADPPHPHLFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM6</accession>
    <name>A0A1E7NGM6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0002940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550353.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2782"/>
    <dbReference type="EnsemblBacteria" id="OEV39856">
        <property type="protein sequence ID" value="OEV39856"/>
        <property type="gene ID" value="HS99_0002940"/>
    </dbReference>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV39856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="351" mass="37856" checksum="FC6C714500D1D170" modified="2017-01-18" version="1">MTVSQGVAATLPDGRSVTRWTIASPSGVRAEVLSLGARLQALYVPDREGRRANVVLGCERAGDLLGEGAYFGATIGRYANRIAHGVLPLDGTTHRLTTQPTGHTLHGGRDGFATRLWDGVPVRDGRRAGVRLRLHSPDGDQGFPGALTVETTYLLDPAGRLCIGYRATTDAPTVVNLTNHAYFNLAGEGNGTVLDHLLRVEARGYLPVDAELIPIGPAARVLGTPFDLREERRIGDRVVDGDQQIRRAGAGFDHNWVLDGNGLRPAAVLSHPASGRRVECLTTEPGLQVYTGNHFDGTLRGPSGRPYGTYAGVALETQHFPDSPNHPEYPSTVLRPGEEFRSMTVYRFSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGW6</accession>
    <name>A0A1E7NGW6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Cytochrome P450</fullName>
                <ecNumber evidence="8">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="8">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0003380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NADPH + 2 oxidized [cytochrome P450] = H(+) + NADP(+) + 2 reduced [cytochrome P450]</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="8"/>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2869"/>
    <dbReference type="EnsemblBacteria" id="OEV39865">
        <property type="protein sequence ID" value="OEV39865"/>
        <property type="gene ID" value="HS99_0003380"/>
    </dbReference>
    <dbReference type="OMA" id="WKKAHNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 8" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="499"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="677"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV39865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1066" mass="115586" checksum="F3E4AE20DDFEA391" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV16</accession>
    <name>A0A1E7MV16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0016265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550560.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000240.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2975"/>
    <dbReference type="EnsemblBacteria" id="OEV32269">
        <property type="protein sequence ID" value="OEV32269"/>
        <property type="gene ID" value="HS99_0016265"/>
    </dbReference>
    <dbReference type="OMA" id="TQKIGYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="24"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="54599" checksum="4D08B55FFAB06F3E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVA9</accession>
    <name>A0A1E7MVA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000462.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6958"/>
    <dbReference type="EnsemblBacteria" id="OEV32366">
        <property type="protein sequence ID" value="OEV32366"/>
        <property type="gene ID" value="HS99_0016845"/>
    </dbReference>
    <dbReference type="OMA" id="GMWMLLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14467" checksum="79E56584CC70483D" modified="2017-01-18" version="1">MLLLGLLLMAASGAFIGLLIADNLAGGPEYQATVLGTEFVKLNSLAIFLSGVALALLFCLGLALMGLARRATRRPVAAAGYRGRAARRVEPVAPPETLDRPGDAAPVTRDERAADQGGQAGAITPEPQRRRGRHLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK9</accession>
    <name>A0A1E7MVK9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386180.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32467">
        <property type="protein sequence ID" value="OEV32467"/>
        <property type="gene ID" value="HS99_0017455"/>
    </dbReference>
    <dbReference type="OMA" id="ANHPIEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198470" evidence="1">
        <location>
            <begin position="34"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="26093" checksum="29B09A90E0F92086" modified="2017-01-18" version="1">MSVLPQHRKLTVGALALATFAISCSSAAASSSAATGKVLWTPSTAKGPSSFVGVQCAAPSSFGVVKDPVKGSVWKAFQAANQERCETVGPDLKEGDTFYLGWSSKVEIGDDQSRYVFQLKCSPSEGTANHPIEIDLTTGRVRLQEWDTEHVAHPLWTAPVKNGEWHAYALKIHLGRSDGTIDFWFDGKKQTFSGGSGTFKGTTWDGDRNYLKWGSYHPNPGDATNTFTSPVMATTLETATAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR9</accession>
    <name>A0A1E7MVR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000793.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7522"/>
    <dbReference type="EnsemblBacteria" id="OEV32526">
        <property type="protein sequence ID" value="OEV32526"/>
        <property type="gene ID" value="HS99_0017170"/>
    </dbReference>
    <dbReference type="OMA" id="YHAVITY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="19051" checksum="892765956B18754F" modified="2017-01-18" version="1">MVWTRAAYPALVEVARRYHAVITYAELAEAVQQASGVRTSINQRHWIGKVLALVVREAHRRGDPPLTSLVVHAADGMVGTGYQDVLAVAGQPPIPDEMDREQHAAAARLACYRHFGADLPADGGIPALAPRLKTAATRRSTTTTTVAAAPAPRPPAICPTCFLELPATRVCDSCGAAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW72</accession>
    <name>A0A1E7MW72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Indole-3-glycerol phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3159"/>
    <dbReference type="EnsemblBacteria" id="ARF78292">
        <property type="protein sequence ID" value="ARF78292"/>
        <property type="gene ID" value="B6264_04605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32671">
        <property type="protein sequence ID" value="OEV32671"/>
        <property type="gene ID" value="HS99_0015480"/>
    </dbReference>
    <dbReference type="OMA" id="PHYVEEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18436" checksum="26E2330AD3B43DB2" modified="2017-01-18" version="1">MPGPGGRPLEGTHVFKTVLMIEKALSDADVELVTTLHSDEKVSFVVLMQPRGKQDELLRALDDVALGHLDKVVREHDESESGPTVASESLEHSLRHLRAAGAEAIGELVEDRPLERLRVAVEEHRADEVVVLTSPHFVEEFFHRDWASQARHKVGVPVLRLFASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWL5</accession>
    <name>A0A1E7MWL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738021.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1991"/>
    <dbReference type="EnsemblBacteria" id="ARF79565">
        <property type="protein sequence ID" value="ARF79565"/>
        <property type="gene ID" value="B6264_12135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32821">
        <property type="protein sequence ID" value="OEV32821"/>
        <property type="gene ID" value="HS99_0039975"/>
    </dbReference>
    <dbReference type="OMA" id="PRSYLLW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="43742" checksum="56F8B5A89B8D7BE3" modified="2017-01-18" version="1">MTTTAPPRPGPSRPGPPRPYLPRPYLFWLAGAQTGLLGDAVLGFALGWAASGYGGGAAGLVLTAITVPRTTLVLLGGAVADRFGARRVMLAGDAVMLAATVALTLAVAGSRGTPLWLLVAAAAVTGTVDAFHLPASGSMPRRLVPADRLPRALALRQAGGQAAVLLGAPLGGLLVAAGGLAGAAAADAVSFGVVLLVLLKVRPEGERPGALRRAGLLGEAAAGVRLAVGDPLLRAALLLTGAAAGALLPVVSLLGPLLARAHGWAAGTAGLVAGGQAVGVLAVAALVAWRGGLPRAGTGAAAGLCTASAGIGLLALSVGPVGAVAGSTVTGIGSGLFASHLGPLVLGGAPASHLSRIQALLTLVQSLPLVLSTGLLGLLADAAGAALPTLLCALATAAAGLTALATPALRRARPGPAATVCPPGPEAHLPAFGPPGRVRRWRRAAASGGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS8</accession>
    <name>A0A1E7MWS8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386331.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene97"/>
    <dbReference type="EnsemblBacteria" id="ARF80108">
        <property type="protein sequence ID" value="ARF80108"/>
        <property type="gene ID" value="B6264_15340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32895">
        <property type="protein sequence ID" value="OEV32895"/>
        <property type="gene ID" value="HS99_0039525"/>
    </dbReference>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28125" checksum="523BCC7D3B5DA34E" modified="2017-01-18" version="1">MTTAAAVYDPQLPGGPSAVAATARQVTKAYGSGETRVTALDAVDVDIQRGRFTAIMGPSGSGKSTLMHCLAGLDTVSSGRIWIGDTEITGLRDKQLTRLRRDKIGFIFQAFNLLPTLNALENITLPMDIAGRRPDQAWLDQVVETVGLAGRLKHRPTQLSGGQQQRVAVARALAARPEIIFGDEPTGNLDSRAGAEVLTFLRRSVDELGQTMVMVTHDPVAAGYADRVLFLADGVIVDEMHAPTADSVLERMRRFDGKRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW7</accession>
    <name>A0A1E7MWW7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0039505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000077">
        <property type="protein sequence ID" value="OEV32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366848.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000131_gene712"/>
    <dbReference type="EnsemblBacteria" id="ARF81758">
        <property type="protein sequence ID" value="ARF81758"/>
        <property type="gene ID" value="B6264_25225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32909">
        <property type="protein sequence ID" value="OEV32909"/>
        <property type="gene ID" value="HS99_0039505"/>
    </dbReference>
    <dbReference type="OMA" id="HNERCKE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2079"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2079"/>
            <end position="2093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="3409" mass="352635" checksum="EFDCAD362610610A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX64</accession>
    <name>A0A1E7MX64_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5692"/>
    <dbReference type="EnsemblBacteria" id="ARF81427">
        <property type="protein sequence ID" value="ARF81427"/>
        <property type="gene ID" value="B6264_23170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33009">
        <property type="protein sequence ID" value="OEV33009"/>
        <property type="gene ID" value="HS99_0014140"/>
    </dbReference>
    <dbReference type="OMA" id="CFLKDYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="499" mass="54528" checksum="A74247AC6B3DD82D" modified="2017-01-18" version="1">MSIEQTDIEQGQNEEEIDYGPGLDPERLRLCLEVLADLDELHVDHPDAITVRKAVGGIFRTLKQRRRQETRARKTANDREVTARTATGAPTRIDDETAGAFGLTTVTTTEIAGILERPRSCYTCKTRYVEVDAFYHNLCQKCAVLNRSRRDARADLTGKRALLTGGRAKIGMYIALMLLRDGAHTTITTRFPNDAIRRFKAMPDSAEWIHRLKIVGIDLRDPAQVMALADEVAADGPLDILINNAAQTVRRPPESYRELVNAESAPLPAGELPQATTIGRFNSGTVDLPALPRQASGGEQRLAAEDVTSLALVTGSATPARIEAGTAIDAGGLVPDLAPTNSWVQTVSEVGPVELLEVQLCNSTAPFILISRLRPAMAASASRRKYVVNVSAMEGVFQRGYKGAGHPHTNMAKAALNMLTRTSAQEMFETDGILMTAVDTGWITDERPHPDKMRLADEGFHAPLDLVDGAARVYDPIVRGEAGEDLYGCFLKDYERGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ6</accession>
    <name>A0A1E7MXJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550920.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000537.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2676"/>
    <dbReference type="EnsemblBacteria" id="OEV33134">
        <property type="protein sequence ID" value="OEV33134"/>
        <property type="gene ID" value="HS99_0014895"/>
    </dbReference>
    <dbReference type="OMA" id="LTRWVAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27031" checksum="4E6F2F328CDE0459" modified="2017-01-18" version="1">MILGLLDGRPLPRTALDERLAALRNGPRSTALPRPGSSEDRQLIRWVAQVLLTEALCEAVAAERELPVTASVTASGTESVAASATAPGPASVTAPGPARLDQRAAVELGSITAAAYEGSAAVRAVYDSVTAEVEPSPADVAHYRALTGRPPVTRWHLVLPDGTFEADPDTLPTALAEALRTAPPGEWVTVGPWTALLLATLAIPQDPDPAPALRDAARRVAFVRWLDRERAQRLTLVEGLEHPGDPAQPDNHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR1</accession>
    <name>A0A1E7MXR1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000074">
        <property type="protein sequence ID" value="OEV33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557779.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000555.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7653"/>
    <dbReference type="EnsemblBacteria" id="ARF78477">
        <property type="protein sequence ID" value="ARF78477"/>
        <property type="gene ID" value="B6264_05705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33191">
        <property type="protein sequence ID" value="OEV33191"/>
        <property type="gene ID" value="HS99_0039345"/>
    </dbReference>
    <dbReference type="OMA" id="LWDPDRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="41159" checksum="CE21C20B8221C33B" modified="2017-01-18" version="1">MPSIHRSALAAALVTGTLLAATACGPDGPGGVDRTAAPPPAADASASASPGGGVIGGITLPSGLPSSLLEGLPKSWDDLKKWKFDDWDKWASKHVFNNPVVKDFWNPDKMGDAKPADPAPPTASPAAADGVTDPEPPVVKAVQVPRPYLKQPSGKVFFSAQGGRGNCSATVIADPQHPGRSNLVWTAAHCVHEGKGGDFYKDLVFVPAYNNSGASSGGRKAPLSELAPLGTWWADQVVTSPQWMVEGGPTGDAANQYDFAVMRVHNQNDTGKSLEETVGSAAPVWFDAPRDQLRVSTVGYPLVKPFDGQELYKCDGGKPTRLSFDAKRPSMLTIGCNMTQGASGGGWFATMPDGRTALVSNTSIGTQEHTSLSGPYLETVAKQALDWISRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU8</accession>
    <name>A0A1E7MXU8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="10" type="ORF">HS99_0038910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283768.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000513.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4499"/>
    <dbReference type="EnsemblBacteria" id="ARF80401">
        <property type="protein sequence ID" value="ARF80401"/>
        <property type="gene ID" value="B6264_17130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33265">
        <property type="protein sequence ID" value="OEV33265"/>
        <property type="gene ID" value="HS99_0038910"/>
    </dbReference>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="535"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="878" mass="97382" checksum="B88EA8399119EB73" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY25</accession>
    <name>A0A1E7MY25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558031.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3396"/>
    <dbReference type="EnsemblBacteria" id="ARF80449">
        <property type="protein sequence ID" value="ARF80449"/>
        <property type="gene ID" value="B6264_17415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33348">
        <property type="protein sequence ID" value="OEV33348"/>
        <property type="gene ID" value="HS99_0012185"/>
    </dbReference>
    <dbReference type="OMA" id="FPVWGAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20880" checksum="6F88431E98446C69" modified="2017-01-18" version="1">MGFLDALFGRTKPVKPDLDQLFGLPSAALTLEAGAGFLPTGLGSVCFAAVEGAAFVQVEQQVRALLDADTERGGVPVEASKDGYGYSWLLARHTPDELPELVNDLHAVNSELEANGFGPQLLCSLVAFRNGEGQSLALVYLYKRGTFYPFAPMPGGGERRNSPLELQVNAMLGNDLRLEKDLSRWFPVWGAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY73</accession>
    <name>A0A1E7MY73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0012310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290783.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000590.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4025"/>
    <dbReference type="EnsemblBacteria" id="OEV33369">
        <property type="protein sequence ID" value="OEV33369"/>
        <property type="gene ID" value="HS99_0012310"/>
    </dbReference>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26699" checksum="F919348263511C0D" modified="2017-01-18" version="1">MTDPIPPAVRLRDAVASRGGRPVLRGVDLTVRPGEVVALLGANGSGKSTTVKAVIGSVPLEQGTLELFGTPYGSFRAWHRIGYVPQRTTAASGVPATVREVVSTGRLAQHRLLPFRRRDRAAVDRALDAVGMLDRAGDGVADLSGGQQQRVLIARALVGTPDLLIMDEPMAGVDAASQQVLADTLRSEVGRGASVLLVLHELGPLEPLIDRAVVLRDGCVAHDGPPVPNTGLHALPGHDHVHPHADLTPPRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYL2</accession>
    <name>A0A1E7MYL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80630">
        <property type="protein sequence ID" value="ARF80630"/>
        <property type="gene ID" value="B6264_18510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33526">
        <property type="protein sequence ID" value="OEV33526"/>
        <property type="gene ID" value="HS99_0013290"/>
    </dbReference>
    <dbReference type="OMA" id="DAPNIPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17203" checksum="9AF9597646632350" modified="2017-01-18" version="1">MTDLSPAAETLSDITTELFAVNGALLRAGDALSARFGLTSARWQVLGLLAEGPQSAAHLARERGLRRQAVQQTVVKLVEEGLVSTSPNPADRRAPLVSLTAKGTDALARIEPAERLWMEHLAGGLDPDDLKATLRLLRGLRAVLAEGLPPTAVGGADAADVTGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS2</accession>
    <name>A0A1E7MYS2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6620"/>
    <dbReference type="EnsemblBacteria" id="OEV33600">
        <property type="protein sequence ID" value="OEV33600"/>
        <property type="gene ID" value="HS99_0012975"/>
    </dbReference>
    <dbReference type="OMA" id="WESATAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198562" evidence="1">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="15565" checksum="819815F14D152022" modified="2017-01-18" version="1">MAAVVGASVLVGCSSSGKSASGTASSALSVAASAGSALASAASQAGSALASAEARASEAVSAASSAISGIKGGLDAKGDVTVGAVTTGTDGKSLAQLTVTNHGEQSYQYVIQVNFTDGNGKVLDATATTVQDLAAGQSVQATARSHLTLSGTVKAEVANAVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ50</accession>
    <name>A0A1E7MZ50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1941"/>
    <dbReference type="EnsemblBacteria" id="ARF79608">
        <property type="protein sequence ID" value="ARF79608"/>
        <property type="gene ID" value="B6264_12395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33707">
        <property type="protein sequence ID" value="OEV33707"/>
        <property type="gene ID" value="HS99_0038140"/>
    </dbReference>
    <dbReference type="OMA" id="QGHTNNE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="580" mass="61015" checksum="BCE06A2082D9514B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB8</accession>
    <name>A0A1E7MZB8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282685.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5249"/>
    <dbReference type="EnsemblBacteria" id="ARF80668">
        <property type="protein sequence ID" value="ARF80668"/>
        <property type="gene ID" value="B6264_18720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33563">
        <property type="protein sequence ID" value="OEV33563"/>
        <property type="gene ID" value="HS99_0013500"/>
    </dbReference>
    <dbReference type="OMA" id="PALIWDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16733" checksum="E473A88AA2EA2D2D" modified="2017-01-18" version="1">MDTREALGSWIDGPKAAAEKMGADFGYRGERLGLPKEGPGSIAGPGRRIGALFVDGWLVSLVSFGMLAKGDPAEANLWTLPLFFLVAVLLLSTTGTTLGKRLFGLRVVRLDGRRATIPQVLLRTLLLCLVVPPLVWDRDTRGLHDKAVGTVEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH5</accession>
    <name>A0A1E7MZH5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="8" type="ORF">HS99_0037490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557796.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000268.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4407"/>
    <dbReference type="EnsemblBacteria" id="ARF80324">
        <property type="protein sequence ID" value="ARF80324"/>
        <property type="gene ID" value="B6264_16680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33836">
        <property type="protein sequence ID" value="OEV33836"/>
        <property type="gene ID" value="HS99_0037490"/>
    </dbReference>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="42385" checksum="C4E705733E2651A9" modified="2017-01-18" version="1">MTSLAHPQLRFTPTVADPSGPRELVILGSTGSIGTQAIDVVLRNPDRFRVVALSAAGGRVELLAGQALQLGVHTVAVADPAAEPALRGALAAKAAGRALPAVLAGPDAATELAAMECHSVLNGITGSIGLRPTLAALRAGRVLVLANKESLIVGGPLVKAVAKPGQIVPVDSEHAALYQALAGGTRAEVRKLVVTASGGPFRTRTREQLAGVTPQDALAHPTWAMGPVVTINSATLVNKGLEVIEAHLLYDVPFDRIEVVVHPQSVVHSMVEFTDGSTLAQASPPDMRMPIALGLGWPDRVPDAAPACDWTKAATWEFFPLDDEAFPAVELAREVGTLGGTAPAVFNAANEECVEAFLKGRLAFTGIVDTVAKVVAEHGTPAAGTSLTVEDVLHAEDWARARARELAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI9</accession>
    <name>A0A1E7MZI9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000751.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6354"/>
    <dbReference type="EnsemblBacteria" id="ARF78770">
        <property type="protein sequence ID" value="ARF78770"/>
        <property type="gene ID" value="B6264_07425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33855">
        <property type="protein sequence ID" value="OEV33855"/>
        <property type="gene ID" value="HS99_0037220"/>
    </dbReference>
    <dbReference type="OMA" id="KARANHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="PTHR16779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="202"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="54602" checksum="A0C7BD320F557A2A" modified="2017-01-18" version="1">MTSTAPVRTVLTTSREAARLAERQMSWKPRVLPFYVAFLIIFSFSLWAYVPNPTPLGWAITVLWGMPVFGVLIGFQGVLMVRRRLRQVDRMTPPAPVEDDFLIVLVPTIGRHDTYPALERSVLSYVEHLPPYFPWMRVDILTEEGCAAAEKIDELAERHPLIRVVTVPKAYETANGTKFKARANHYSHELRIEEGEAEDDVWVLHMDDDTGVGPDTAAAVAQFVNRQRRAGDDAKHMAQGILTYPRENAVSTFTWLADAIRPADDIARFRAMTGTGTPIAGVHGELLIVRSSVEATIGWDFGPKTIVEDAQLALNFCQRYPGRSDWFNGRCYGASPAGVKDFLKQRERWAWGLVALCFNKTIPLRYRLFIGMGMVSWVLGPLQHVGLVLMVAWFTGTWNTSPVTQSVVLLWAINFAYVIWTYWEGLRLNVVSSANHRRKWWEPIVVVACIPLFSFLEGWGGLRGLIKFLKREENKFVVIAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK5</accession>
    <name>A0A1E7MZK5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386089.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6385"/>
    <dbReference type="EnsemblBacteria" id="ARF78744">
        <property type="protein sequence ID" value="ARF78744"/>
        <property type="gene ID" value="B6264_07270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33877">
        <property type="protein sequence ID" value="OEV33877"/>
        <property type="gene ID" value="HS99_0037375"/>
    </dbReference>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="31796" checksum="A0914884354A949D" modified="2017-01-18" version="1">MTARTQRTRLLAAGVAAVSVSLVLSGCSSSKSSEGGGAPNASATVNAVKADDKLVALVPADVKSAGKLVVGADASYAPDEFKDDSGKVIGMDVDLADAIAAKLGLKAEVQDSGFTAIIPGIQSNKFQLGMSSFTDNKEREQVVDMVTYFNSGSAIAVKKGNPNKIDPKDLCGKKVAVQTGTTQADEIKDTRNPDCAKAGKPGIQNDGDKFDLQTDVTNAVVSGRDDAMMADSQVVDYAIKQSGGQLEKLGDTYGVAPYGVALAKGSKLTPAVQGAIQSLIDDGTYKQILTKWGVEAGALDKSTVNGAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW5</accession>
    <name>A0A1E7MZW5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase class II</fullName>
            <shortName evidence="2">Fumarase C</shortName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aspA</name>
        <name evidence="2" type="synonym">fumC</name>
        <name evidence="3" type="ORF">HS99_0010975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280262.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2201"/>
    <dbReference type="EnsemblBacteria" id="ARF77830">
        <property type="protein sequence ID" value="ARF77830"/>
        <property type="gene ID" value="B6264_01820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33972">
        <property type="protein sequence ID" value="OEV33972"/>
        <property type="gene ID" value="HS99_0010975"/>
    </dbReference>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="2">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="468" mass="50113" checksum="7D4DB4026B4F8F42" modified="2017-01-18" version="1">MGDEREKPQEYRIEHDSMGEVRVPAAAKWQAQTQRAVENFPVSGQRLERAHIAALARIKAAAARVNARLGVLDEETAGAIAAAAEEVAEGRWDDQFPVDVFQTGSGTSSNMNANEVIATLAGERLGRPVHPNDQVNASQSSNDVFPSSIHIAATGAVTDDLIPALEHLAEALERKSVEFAQVVKSGRTHLMDATPVTLGQEFGGYAAQVRHGRERLLATLPRVAELPLGGTAVGTGINTPPGFPAAVIEEVARTTGLPLTEARDHFEAQGARDALVELSGQLRTVAVGFTKIANDLRWMGSGPRTGLGEINLPDLQPGSSIMPGKVNPVLPEVVLMVAAQVVGNDATVTLAGASGNFELNVMLPVIARNVLESVRLLANSARLLADRTVDGITANVERAREYAESSPSVVTPLNRYIGYEEAAKVAKQALAERKTIRQVVLERGYVERGELTEEQLDRALDVLRMTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N048</accession>
    <name>A0A1E7N048_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557789.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4398"/>
    <dbReference type="EnsemblBacteria" id="ARF80315">
        <property type="protein sequence ID" value="ARF80315"/>
        <property type="gene ID" value="B6264_16630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33843">
        <property type="protein sequence ID" value="OEV33843"/>
        <property type="gene ID" value="HS99_0037540"/>
    </dbReference>
    <dbReference type="OMA" id="ERWICQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33098" checksum="4985501B9FCD3645" modified="2017-01-18" version="1">MMDLGRLRALHAVAVHGSVGRAAAALGFTPSAVSQQIAKLERETRTVLLERQGRGVVLTDAARELAATARTVLGLMERAEVRLEEQRGQAVGRLLVAAFATGARGLMPGVLAELRRRCPEVDVRLLESDPYPAAELVGRGEVDLALVQDWPSVPLPVQEGLSRLDLGTDPVDLVLPADDDLAALDAVPVERLRGQRWISVPPGNICHDWLVRTLREAGEEPDVRYQVDDFETQIALVAAGLGMAVVPRLGRGPLPAGVAARPVASQPSRRVFALWRAQASRRPAITEALAVMKDCWAAVEEAQRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D3</accession>
    <name>A0A1E7N0D3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070043281.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3730"/>
    <dbReference type="EnsemblBacteria" id="ARF78000">
        <property type="protein sequence ID" value="ARF78000"/>
        <property type="gene ID" value="B6264_02815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34136">
        <property type="protein sequence ID" value="OEV34136"/>
        <property type="gene ID" value="HS99_0011960"/>
    </dbReference>
    <dbReference type="OMA" id="VNTSDNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="46156" checksum="C0730149BCE440A4" modified="2017-01-18" version="1">MSRSSRRSLRTAAALVATAAAASLFTAAPQAQATSSMGGQITRSEVLARAQYWVDNHVPYNQGGYAPDPQGSTYREDCSGYVSMAWHLNSSLVTSTLPSVSTHENFSDLKSGDILDYTAEHTFLFANWTNQSNGDFTYYAESNPNDPTHGPNSANINSSSLEGWPTSYYGAYRYNNIVDDAAPRPARVAAGDFNGDGKLDVVGVDANSNMQYYPGNGAGSVSGPGTPMLGTTGLWANFKAVAAGDFTGTGHTGVAGIDANNNMMFYTGDGAGHLSGGINMMPGTNGLWANFKAITAGDFTGTGKLGIAGIDANNNMMFYPGDGAGHLGTGIPMLGTSGLWAGFKAITAGDFTGTGKLGIAGIDANNNLKFYPGDGAGHVSSAAIAMLGTNGLWANFHAVMAGDFTGTGKLGIAGIDANNNLKFYPGDGAGHVSGGTQMLPGNGLWAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F5</accession>
    <name>A0A1E7N0F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carnitine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2216"/>
    <dbReference type="EnsemblBacteria" id="OEV34162">
        <property type="protein sequence ID" value="OEV34162"/>
        <property type="gene ID" value="HS99_0011050"/>
    </dbReference>
    <dbReference type="OMA" id="RFWRTAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="48522" checksum="3BF576D44E25E6CA" modified="2017-01-18" version="1">MEPAPRPTPGPADRPTADVWAALGGPAELLDRVGFHGPPDGLPSGLPVRQLARATVAACSLAAAELAAHRSGGPVPAVRVDEGAVATSFVSERHLEVDGRKPVSFAPLSGFWRTADGWVRTHANYPHHRARLLAVLDLAPDAGPEQLAGALGKLPAEQVQERAYAAGALAVAVAPVSGDVHPLMECREVGAAPVRPLPAAPVDRPATGIRVLDLSRVISGPVATRTLALLGADVLRIDSPRLPEADDAHTDTGFGKRSTRLDLADPADRAAFEGLLDTADVVVSAYRPGALDAHGLAPDALFARRPDLILAQLCAWGWTGPRAGRRGFDSLVQAGVGIAAHEASPDGRPGALPAQALDHGTGYLLAAAVLRALTEQRTRRPGGRHLRFSLAGTASWLLHGIRPEPADASGPDSRPYDASHWLTETDSAYGRLRYALPPIGYDGAPADWARPPGRWGTDAPVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N7</accession>
    <name>A0A1E7N0N7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280128.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2280"/>
    <dbReference type="EnsemblBacteria" id="ARF77891">
        <property type="protein sequence ID" value="ARF77891"/>
        <property type="gene ID" value="B6264_02195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34033">
        <property type="protein sequence ID" value="OEV34033"/>
        <property type="gene ID" value="HS99_0011345"/>
    </dbReference>
    <dbReference type="OMA" id="FNYGEGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="31694" checksum="B82E4469233CC143" modified="2017-01-18" version="1">MDVCVIGGSRYFGRRVVEELRDSGAAVTVLNRGSTPAPYGVTHLRADRDDEASLRAALADRRFDAVVDQVCYTPVQAAVAARVFAGRTPRYVLTSTVEVYAHLGQPGGPPLAEPELDLSAEPVDLQLLWDDVQFVADHYAEGKRQAEALLTRQAAFDLATVRTAHVLGGADFTGRLAHYVDRIGRGIPVAVHAAPQRASFVHEAEIARFLAWAAKADFTGPVNAASQGPMDVRELCAAVGRATGAEPRLTTGGGEAPSPFSFDRCYAMDTGRAARLGYRFSAVTDWLPQAVKEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P1</accession>
    <name>A0A1E7N0P1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="8" type="ORF">HS99_0036795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6041"/>
    <dbReference type="EnsemblBacteria" id="ARF82602">
        <property type="protein sequence ID" value="ARF82602"/>
        <property type="gene ID" value="B6264_03695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34258">
        <property type="protein sequence ID" value="OEV34258"/>
        <property type="gene ID" value="HS99_0036795"/>
    </dbReference>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="46265" checksum="CDB54AFE261ACB5E" modified="2017-01-18" version="1">MTDIVDELRWRGLIALSTDEDALRKAFADGPVTFYCGFDPTAPSLHLGNLVQILTMRRIQQAGNLPLGLVGGATGLIGDPKPTAERVLNDPETVAGWVERLRGQVSRFLDFEGPYAARMVNNLDWTSGMSAISLLRDVGKYFRVNNMIAKEAVARRLNSDAGISYTEFSYQILQGMDYLELNRRYGCTLQTGGSDQWGNLTAGTDLIRKADGKSVHALATPLIVKADGTKFGKTESGTVWLDPELTTPYAFYQFWLNADDRDVSNFLRIFSFRSKEEIEELERETAERPAARLAQRALAEELTTLVHGAEQYERAVAASKALFGQGDLADLEAPTLAAALAEVPKAEVTELQPVVDLLVAVGLAPSRSAARRTIKEGGAYLNNVKVTDEEAVPTEADLLHGRWLVLRRGKRNLAAAELVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N168</accession>
    <name>A0A1E7N168_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1080"/>
    <dbReference type="EnsemblBacteria" id="ARF78966">
        <property type="protein sequence ID" value="ARF78966"/>
        <property type="gene ID" value="B6264_08580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34437">
        <property type="protein sequence ID" value="OEV34437"/>
        <property type="gene ID" value="HS99_0035615"/>
    </dbReference>
    <dbReference type="OMA" id="WEFDVLT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="18477" checksum="0B1F4CAE2C8BAF09" modified="2017-01-18" version="1">MEDEVDRLVAAWRRERPDLDVEPLEVLSRVSRLARHLDRARRTAFAEHGLEPWEFDVLTALRRAGSPYQLSPGQLLTQTLVTSGTMTNRIDRLTGKGLVKRLPDPDDRRGVLVRLTDDGRDRADQALAGLLTHERELLAQLSSGQQGELAALLRLLVAPFDNIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N186</accession>
    <name>A0A1E7N186_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">HS99_0035745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290807.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1055"/>
    <dbReference type="EnsemblBacteria" id="OEV34458">
        <property type="protein sequence ID" value="OEV34458"/>
        <property type="gene ID" value="HS99_0035745"/>
    </dbReference>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="428" mass="45607" checksum="ACC6D2AF214929B7" modified="2017-01-18" version="1">MPSIDVVVAREILDSRGNPTVEVEVGLDDGSTGRAAVPSGASTGAFEALELRDGDKNRYFGKGVEKAVLAVIEQIGPELVGYDATEQRLIDQAMLDLDATPDKSSLGANAILGVSLAVAHAASEASDLPLFRYLGGPNAHVLPVPMMNILNGGSHADSNVDIQEFMIAPIGAESFSEAVRWGVEVYHTLKGVLKERGLSTGLGDEGGFAPNLDSNREALDLITEAIQKAGYVPGRDVALALDVAASEFFKDGAYQFEGKALSSAELIEYYAELVAAYPLVSIEDPLDESDWDGWKAMTDKLGDKVQLVGDDLFVTNPARLAKGIETGTANALLVKVNQIGSLTETLDAVELAQRNGYRCMMSHRSGETEDVTIADLAVATNCGQIKTGAPARSERVAKYNQLLRIEEILDDAAEYAGRGAFPRFRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I1</accession>
    <name>A0A1E7N1I1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552819.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5580"/>
    <dbReference type="EnsemblBacteria" id="ARF79336">
        <property type="protein sequence ID" value="ARF79336"/>
        <property type="gene ID" value="B6264_10760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34548">
        <property type="protein sequence ID" value="OEV34548"/>
        <property type="gene ID" value="HS99_0035240"/>
    </dbReference>
    <dbReference type="OMA" id="GWGQLKI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="56521" checksum="9E881DA01EBA8017" modified="2017-01-18" version="1">MHHHTLSDLYLRLSLDRDGKTAIERQEADCRAWAERHGLTVRKVHIDRGRSGFKDVERKGFDSALAAVTAGVVGTLIVWKLDRLSRKGIGQVGKVLDDIEKAGGRLVSVVDGLDTSNDSARMVVAMLAELARSESKNLGTRVAHAKRHLRRQGQWIGGQPPYGLLVDPTTKKLTHDPDTAVYARLIADGALAGKSLVQIARLLNEYDIPSARGGQWNAASIMNLVKSPAFAGLMPETETIEAEDGSRKFTSRVFPYRDPETLDTVSIGEGIITVGERERIIRQLESRTRVHAGKRMPKPNGTALLTSLVFCDVPGCGRRMHKVGNSYQCMARRAGNQCPGASAMADRVDEYVSERFLSMLPALELDDPMLVAIADRWVKRADPETFAKRGAIADEIADQEARLADLEDARYVRGEFDRPGALDRYDRLAARLQSRIDGLRADLTALPLPAVDITPLLDGELLRAAWAAATQDQKRDRLSLAIDGVFISKGQRGKRFIPEQRVRIKWAEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J7</accession>
    <name>A0A1E7N1J7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34551">
        <property type="protein sequence ID" value="OEV34551"/>
        <property type="gene ID" value="HS99_0035260"/>
    </dbReference>
    <dbReference type="OMA" id="VKDLCVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006448">
        <property type="entry name" value="Phage_term_ssu_P27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05119">
        <property type="entry name" value="Terminase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01558">
        <property type="entry name" value="sm_term_P27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15241" checksum="254FB07247C4CB90" modified="2017-01-18" version="1">MIVPRAILAEPNWRDIFKDSPTAQTQEANIRCRKVASAEWRRIVPILEFAAGLGEVDHTTVKDLCVCVARIDQAERDLSERGLMVTAERGTVKNGAATIATQYRSQLSRYIRELGLSPSARVAIAPTESEDDSDIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1S9</accession>
    <name>A0A1E7N1S9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81975">
        <property type="protein sequence ID" value="ARF81975"/>
        <property type="gene ID" value="B6264_26575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34660">
        <property type="protein sequence ID" value="OEV34660"/>
        <property type="gene ID" value="HS99_0009205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="62" mass="6541" checksum="A3AB7F003313246F" modified="2017-01-18" version="1">MISFLTRSMVETLSSPLHATYASSPSWLTATPKGMDSPVTVCTTVCVAVSMTSSLLPPYSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1T6</accession>
    <name>A0A1E7N1T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554711.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4256"/>
    <dbReference type="EnsemblBacteria" id="ARF81993">
        <property type="protein sequence ID" value="ARF81993"/>
        <property type="gene ID" value="B6264_26700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34642">
        <property type="protein sequence ID" value="OEV34642"/>
        <property type="gene ID" value="HS99_0009090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12600" checksum="8E27FC92F4DC285C" modified="2017-01-18" version="1">MRIDRGKDFLSRTVTSALGALAIPGHNLPAYSPHLKGTVENLNRCAERMLFASLPRYTHTPAPRCAARTGRRTPCGMSLSAHGQARRRSPLDRVPCLRRSPRADSAGLACRGAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1X2</accession>
    <name>A0A1E7N1X2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0035770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290820.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000867.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1050"/>
    <dbReference type="EnsemblBacteria" id="ARF78938">
        <property type="protein sequence ID" value="ARF78938"/>
        <property type="gene ID" value="B6264_08425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34463">
        <property type="protein sequence ID" value="OEV34463"/>
        <property type="gene ID" value="HS99_0035770"/>
    </dbReference>
    <dbReference type="OMA" id="LNIMYGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="17"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="6">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="498"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="6">
        <location>
            <begin position="751"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="851" mass="87682" checksum="CCBE1C3927AC8BE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N214</accession>
    <name>A0A1E7N214_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555915.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81916">
        <property type="protein sequence ID" value="ARF81916"/>
        <property type="gene ID" value="B6264_26220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34722">
        <property type="protein sequence ID" value="OEV34722"/>
        <property type="gene ID" value="HS99_0009555"/>
    </dbReference>
    <dbReference type="OMA" id="PTTIRLQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="18397" checksum="3B944411F79AC7D1" modified="2017-01-18" version="1">MPALRTGLAALTAAVLLGATTVAVQTSVTAAEAVPAPARGIAHLNTVVNLPPGVWTDTPLEVTLPLAGTYELDANVRGRLAGVPPVNTFITARLWDVTSGTAVAESERLVYQVIDLNPGNAQAGGNATAPISELIRVNKPTTIRLQGTRSDAVGTALVAQIYDDNAGHTSLRFDRVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N229</accession>
    <name>A0A1E7N229_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555906.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4633"/>
    <dbReference type="EnsemblBacteria" id="ARF81912">
        <property type="protein sequence ID" value="ARF81912"/>
        <property type="gene ID" value="B6264_26195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34726">
        <property type="protein sequence ID" value="OEV34726"/>
        <property type="gene ID" value="HS99_0009580"/>
    </dbReference>
    <dbReference type="OMA" id="CIGIEPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33164" checksum="E91131502BDAD974" modified="2017-01-18" version="1">MTSSPPLDVVTVGETMAALRATGPVRLGAPMRLSVAGAEANVAIGLARLGHRTGWVGRVGDDEFGALVLRTLRAEQVDVSHARVDTEGRPTGLLAREDRIADLVSVTYYRSGSAGSTLRPSDVLPALNPGVRILHLTGITPALSSEAAEAVHAAAARAGELGITVCLDVNYRARLWSPAEARDALLPLARLADVLVASADELDLVGEDSSLPEGEAIDALLAQGCGEVVITRGGDGASATTAQGTVSMIARRVPVVDVVGAGDAFVAGYLSGLLDGLDVEGRLHRATTTGAFAVTSRGDWEGLPTRRDLTLLDQPAGTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N3</accession>
    <name>A0A1E7N2N3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0035020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554119.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5881"/>
    <dbReference type="EnsemblBacteria" id="OEV34925">
        <property type="protein sequence ID" value="OEV34925"/>
        <property type="gene ID" value="HS99_0035020"/>
    </dbReference>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="25704" checksum="DD69AB45E49E5F41" modified="2017-01-18" version="1">MKIALMDSGIGLLAAADALRKLRPDVDLVLSSNPASMPWGPLTPEEVTELALGCCRAAAALEPDALVVACNTASVHALATLRAELEPGLPVIGTVPAIKPAAALGGRVAIWATPATTGSDYQRGLIRDFGGTADVTEVACPGLADAVEHGDEDATAAAIADAAARTPHGTDVIVLGCTHYELVADRIRAAVAPTASPALALLGSADAVAAQALRRVADPTRTGTGTLTVLHAGLPATLPPTATLYPQGLTLAPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2W7</accession>
    <name>A0A1E7N2W7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muramoyltetrapeptide carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0034375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290524.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4699"/>
    <dbReference type="EnsemblBacteria" id="OEV35022">
        <property type="protein sequence ID" value="OEV35022"/>
        <property type="gene ID" value="HS99_0034375"/>
    </dbReference>
    <dbReference type="OMA" id="YWSAPTC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198716" evidence="1">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="3">
        <location>
            <begin position="124"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26144" checksum="02C68ED7584772CF" modified="2017-01-18" version="1">MNRSSLDRRSILRYGTGVVAAAGLAAVAEVGLAGPAAAYGWSGPLGQGSSGAAVAELQIRVAGWAADSASQTYVAVDGSFGPGTAAAVRRFQAAYGLSADGVAGPQTFGVLNSLEKSDGSTAHFDWSEFTSHDGSGFGGGNVGSGEVQENVRRTMYKLEALRKKAGGHAITVNSGFRSTSYNAQVGGASNSMHTDGVAADIAVSGLSTLSVYRIAETCGFSGLETYTVSWQHVDSRVEHGNYGSGFWWWQDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3C9</accession>
    <name>A0A1E7N3C9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0033900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285475.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4481"/>
    <dbReference type="EnsemblBacteria" id="OEV35175">
        <property type="protein sequence ID" value="OEV35175"/>
        <property type="gene ID" value="HS99_0033900"/>
    </dbReference>
    <dbReference type="OMA" id="FPWLRPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="221"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="47321" checksum="5C802F8B6720ABF4" modified="2017-01-18" version="1">MSTPPRPAGGPSGVPAGGPRAVPPKPAHAPHQGRPRQPETYVPGDGLLAWLPFRPTIRMRLTLLYGGMFLMAGVVLLLVMYFFVQQALQQVGQPHLLLNGIPVRTPDGQIISNQSALDQWLNDYRSYQAGQALNTLLRKLLTVLVCLSVIAFAAGYAMAGRVLRPLGRITRTAREVASSDLHRRIELDGPDDELKELADTFDDMLDRLDRSFDSQRRFVANASHELRTPLAINRTLLEVQLSDPAASPDLQQLGRTLLATNERSEQLVEGLLLLARSENELTDRRSVELSEVATRALEQTRSEADKREVELRSKLDPAVVAGNGVLLERLALNLLQNAVRYNTPGGWVELATATVPGGGELVVSNTGPVVPGYELEHIFEPFRRIKGADRTRSDKGVGLGLSIVRSVVRAHGGTIEATPRAGGGLTMRVRIPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F7</accession>
    <name>A0A1E7N3F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent RNA helicase HrpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000681.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6147"/>
    <dbReference type="EnsemblBacteria" id="ARF79294">
        <property type="protein sequence ID" value="ARF79294"/>
        <property type="gene ID" value="B6264_10535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35231">
        <property type="protein sequence ID" value="OEV35231"/>
        <property type="gene ID" value="HS99_0033500"/>
    </dbReference>
    <dbReference type="OMA" id="YERVTLY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1326" mass="149034" checksum="E1756B6760B7378D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q6</accession>
    <name>A0A1E7N3Q6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0033145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5322"/>
    <dbReference type="EnsemblBacteria" id="ARF80730">
        <property type="protein sequence ID" value="ARF80730"/>
        <property type="gene ID" value="B6264_19085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35305">
        <property type="protein sequence ID" value="OEV35305"/>
        <property type="gene ID" value="HS99_0033145"/>
    </dbReference>
    <dbReference type="OMA" id="WYINSGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="592" mass="62342" checksum="218C8D92C1F8F5C6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y5</accession>
    <name>A0A1E7N3Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480479.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2391"/>
    <dbReference type="EnsemblBacteria" id="OEV35409">
        <property type="protein sequence ID" value="OEV35409"/>
        <property type="gene ID" value="HS99_0032740"/>
    </dbReference>
    <dbReference type="OMA" id="TECEQWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043968">
        <property type="entry name" value="SGNH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19040">
        <property type="entry name" value="SGNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH" evidence="3">
        <location>
            <begin position="439"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="665" mass="70184" checksum="36AFBE0A54CEC69D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N432</accession>
    <name>A0A1E7N432_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1608"/>
    <dbReference type="EnsemblBacteria" id="OEV35432">
        <property type="protein sequence ID" value="OEV35432"/>
        <property type="gene ID" value="HS99_0032235"/>
    </dbReference>
    <dbReference type="OMA" id="WWSNIAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033396">
        <property type="entry name" value="DUF5107"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17128">
        <property type="entry name" value="DUF5107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="633" mass="68809" checksum="46B388C8A3B64EFA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N477</accession>
    <name>A0A1E7N477_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0031805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386267.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5532"/>
    <dbReference type="EnsemblBacteria" id="ARF79379">
        <property type="protein sequence ID" value="ARF79379"/>
        <property type="gene ID" value="B6264_11000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35490">
        <property type="protein sequence ID" value="OEV35490"/>
        <property type="gene ID" value="HS99_0031805"/>
    </dbReference>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="38159" checksum="83FEC84B17284E7B" modified="2017-01-18" version="1">MQLHDVWFVLIAVLWIGYFFLEGFDFGIGILTKPLARNTAERRVLINTIGPVWDGNEVWLLTAGGATFAAFPDWYATLFSGFYIPLLAILVCLIVRGVAFEYRAKRDGARWQRNWEEAIFWTSLVPAFLWGVAFANIVRGVDIDAQKNYVGGLADLLNPYALLGGLVTLTLFTFHGAVFAALKTVGEIRERARAAALRAGLAAAVLALAFLLWTQADSGNGRSLVALVVAVLALAGALVANQLGREGWAFVLSGATVVAAVAMLFLALFPNVMPSTLNPAWSLTVGNAASSPYTLKLMTVVAAVFTPLVLLYQGWTYWVFRKRIGVQHIPAAHRPAAPAAPATPATPTASADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F5</accession>
    <name>A0A1E7N4F5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0006490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282905.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000534.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5356"/>
    <dbReference type="EnsemblBacteria" id="ARF80760">
        <property type="protein sequence ID" value="ARF80760"/>
        <property type="gene ID" value="B6264_19255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35568">
        <property type="protein sequence ID" value="OEV35568"/>
        <property type="gene ID" value="HS99_0006490"/>
    </dbReference>
    <dbReference type="OMA" id="RNKQFTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="257"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="445" mass="46086" checksum="54668E869869F2DE" modified="2017-01-18" version="1">MPLTPEDVRNKQFTTVRLREGYDEDEVDAFLDEVEAELTRLLRENEDLRAKLAAATRAAAQNQANMRKEPPQDAQRPAAPVPAAISGPPVPGQQGPGGQQQMGPGGPQQMGPGGPQQQQMGNQPLGLPSGAPQLPAGQGGPMGPGGPQQMNQTMGGQQQLVQPMGGQMLQPMGGPGGPQQMGNPMGQGMGQQQQMQPMGGPMGGPPQQMGGPLGGPMQQQGPGGDSAARVLALAQQTADQAISEARSEANKIVGEARSRAEGLERDARAKADALERDAQEKHRVAMGSLESARATLERKVEDLRAFEREYRTRLKSYLETQLRQLESQADDSLAPPRIPATASLPPAASSMAPAGGGSMGSAPSFGGNQPSFGGNSPSFGGQSSFGGNAPAPSFGGQGGGNSGAPQMQPAGMTQPMAAVRPQPPQPMQQAPAPMRGFLIDEDGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z2</accession>
    <name>A0A1E7N4Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551022.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene792"/>
    <dbReference type="EnsemblBacteria" id="ARF80964">
        <property type="protein sequence ID" value="ARF80964"/>
        <property type="gene ID" value="B6264_20455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35755">
        <property type="protein sequence ID" value="OEV35755"/>
        <property type="gene ID" value="HS99_0007680"/>
    </dbReference>
    <dbReference type="OMA" id="GFWQAAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027576">
        <property type="entry name" value="Choice_anch_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006946">
        <property type="entry name" value="DUF642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04862">
        <property type="entry name" value="DUF642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04362">
        <property type="entry name" value="choice_anch_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="20641" checksum="7F66F5D7AA6B5442" modified="2017-01-18" version="1">MSFSRTRTAALALAVAATALTTTALAAPAQAAGHRAFSRFDDGSFESPKAPAGNFTEFAAGQTIGPWRVTSGSVDLIGAGMWQAAEGDQALDLNGNAAGTIAQTFTTVPGATYSVTYALAGNPDGGVALRTGRALIDGQDFQDYSFDVTGRTRAAMGYVGRQFSFVAQNSSTTLAFESTVGGPYGPVLDNVQVKECKSCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R5</accession>
    <name>A0A1E7N5R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281414.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene741"/>
    <dbReference type="EnsemblBacteria" id="ARF81004">
        <property type="protein sequence ID" value="ARF81004"/>
        <property type="gene ID" value="B6264_20715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35793">
        <property type="protein sequence ID" value="OEV35793"/>
        <property type="gene ID" value="HS99_0007940"/>
    </dbReference>
    <dbReference type="OMA" id="GQCVHKI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="39788" checksum="877E8B95E29D0DD2" modified="2017-01-18" version="1">MTEVLLAVGTEKGLFLGRSRDRLDWEFSGPHFRMNAIYSVSIDRREGRTRLLVGADSSHWGPSVWRSDDLGANWHAPSRPAIRFPESTGASLTRVWQLQPAGPEAPGVVYAGTEPAALFRSTDGGETFALVESLWNHPQRPEWGAGYGGQGLHTILTDPRDPQRLLVAVSSGGVYRSKDGGDSWTPSNTGLRAEFFPAERQYPEFGQCVHKIAPDPVHPDRLYLQNHGGVYRSDDWGGSWRSIADGLPAEFGFAVAAHPRRGDTAYLFPLGGSDDRIPPGHRCRVFRTTDAGTSWEQLADGLPGQDHYGIVLRDALRTDDADPAGIYFGNRTGDVYGSRDEGGTWSLLVSHLPDVLCLRAAVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N665</accession>
    <name>A0A1E7N665_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737895.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8117"/>
    <dbReference type="EnsemblBacteria" id="ARF79777">
        <property type="protein sequence ID" value="ARF79777"/>
        <property type="gene ID" value="B6264_13460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36168">
        <property type="protein sequence ID" value="OEV36168"/>
        <property type="gene ID" value="HS99_0030415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26499" checksum="403544826D7E8EE6" modified="2017-01-18" version="1">MPTPHGSRGGMAFSADEVRVLRRALAQALHPAVPAHLQGPDRTAFAGPGAELWAEDVQDALRLTEAIDEAVQEGGRLRAFLLADLGRYRSALPGSAPGYLERLEEAVTDGYLPGPEDLTALRGLTRQPCGHGERARRSRLAGRCHALAEAAVRERLALTAGPPRHLVAVPNPAAPPSSHPTPVGGRTTMSSTDSRDSRPEQPAATPTPPRPHRMPTPADLFGHRTKPPSRPAEPAEDTPDEIELRTGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C1</accession>
    <name>A0A1E7N6C1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287431.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000409.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene482"/>
    <dbReference type="EnsemblBacteria" id="ARF78835">
        <property type="protein sequence ID" value="ARF78835"/>
        <property type="gene ID" value="B6264_07815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36003">
        <property type="protein sequence ID" value="OEV36003"/>
        <property type="gene ID" value="HS99_0031320"/>
    </dbReference>
    <dbReference type="OMA" id="FPWYGLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="23288" checksum="B909E0DEA883A766" modified="2017-01-18" version="1">MDATSQAGGATATAGGPVVGGQAGPADPLLPYLSADFPWYGLDEGWTGRRFLMQAGAGGARAGAAGVDYGTLGHGDEPARQFEPRDLRKFAVVVTVARRGSRRSADNTGTLEATSASSAAWLAGSGLLAATWPGQLDRTLRQDWLDQQSTLAWDLADDLAGPGWSTLSLPVNGLPQPFRYRESEYGWVLAGEAPGVLLGAFGRGVSAYGIGFSTVPDLSGYTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M3</accession>
    <name>A0A1E7N6M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2625"/>
    <dbReference type="EnsemblBacteria" id="OEV36294">
        <property type="protein sequence ID" value="OEV36294"/>
        <property type="gene ID" value="HS99_0030265"/>
    </dbReference>
    <dbReference type="OMA" id="CDRIDSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="7">
        <location>
            <begin position="110"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="8">
        <location>
            <begin position="379"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="530" mass="54860" checksum="00AEE42AF99BF0D3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N4</accession>
    <name>A0A1E7N6N4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284465.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000773.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82373">
        <property type="protein sequence ID" value="ARF82373"/>
        <property type="gene ID" value="B6264_28980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36338">
        <property type="protein sequence ID" value="OEV36338"/>
        <property type="gene ID" value="HS99_0029680"/>
    </dbReference>
    <dbReference type="OMA" id="MSGNAPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="10888" checksum="D9A5E7BB7BC4ADCB" modified="2017-01-18" version="1">MGDRGTNETAGGATDGAPNEQTGETTSVADGVGDGGGPRELSRAAAVGATVLSVLCGCAVLLAMLHWLGWAVPGVGWIVAKAGVKLAVGGFAGLAVAAAWLRAKFGAQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W2</accession>
    <name>A0A1E7N6W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554238.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene221"/>
    <dbReference type="EnsemblBacteria" id="OEV36442">
        <property type="protein sequence ID" value="OEV36442"/>
        <property type="gene ID" value="HS99_0029330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="45134" checksum="C34D98ED9E494EFB" modified="2017-01-18" version="1">MATIPQITATEEPDGLSGEKAAPPLYFELSTNPDPVRVSPSSGDPERADFVLVGSRRSTLAIDCRKVIVNVSTGNNSPDLTPDLNSVNAQISLAGWTATTNTTAKTITFTPTSGHATIGPAQGITIQLMGMRINTVVGSSPLRIDVEWAESGDDYWTTDSTVIDVGKFPPDFVLRNFIPEQLVIDNGGSVKLNWEAGGASSLKLLYDVAEVNVLGKSTYTVNNVRSTTVFYLRATVQVGTGTVERILSTTVTVRVPDLEVRNLKVTGDLTAVTSGTTVRIRDLRGPYGAPLRVNSHLEVLTGNNVSIADNLTVGGDVNATATGRVVRIRDLRGPYGVPLRVNSHLEVLTGNNVSIADNLTVGGKSVLRDQDSVRIRNNNYPENHLNATTAFGTDNSGNFIAAAYWRKNSYDSASTMTLEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N705</accession>
    <name>A0A1E7N705_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0029435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289745.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene198"/>
    <dbReference type="EnsemblBacteria" id="OEV36458">
        <property type="protein sequence ID" value="OEV36458"/>
        <property type="gene ID" value="HS99_0029435"/>
    </dbReference>
    <dbReference type="OMA" id="EWAPCVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="24087" checksum="B965C36E1BDCEEAD" modified="2017-01-18" version="1">MAAEPVEAAASAAPAAPGTPGTPERPGTPGTVRPGGRTARVRAAVLRAAEDALVEHGFGGLDLADLAQRAEVGRTTVYRRWGSTTALVADLLTDMAEQSLPRSRSGSLAEDLRANARLVRRTLADPRQGALFRAVIVAANGDPGTAEALRHFYRRRVEEWAPCVTEAVERGELPPDTDPFEVIRAVSAPLYYRMLTTAEPLDEPAADRAAAAAEAAARAGAYRRQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N789</accession>
    <name>A0A1E7N789_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4892"/>
    <dbReference type="EnsemblBacteria" id="ARF82377">
        <property type="protein sequence ID" value="ARF82377"/>
        <property type="gene ID" value="B6264_29010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36333">
        <property type="protein sequence ID" value="OEV36333"/>
        <property type="gene ID" value="HS99_0029650"/>
    </dbReference>
    <dbReference type="OMA" id="DFPTLAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="516" mass="54680" checksum="416F4567B6E541B0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F8</accession>
    <name>A0A1E7N7F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36609">
        <property type="protein sequence ID" value="OEV36609"/>
        <property type="gene ID" value="HS99_0027910"/>
    </dbReference>
    <dbReference type="OMA" id="AMMHAMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15958" checksum="C76F9876D17F0863" modified="2017-01-18" version="1">MNARFERLAQRVRDELAAAGLPVVAPGLDDELAVGAAVRISSWNQHFGEDPEVLVSWHTSPRLRSRATADLRRYAAPTPAVVLGDQVHRAMSAAVTAILSAAGFTVRASGNDYAPFDVLVVEGPDFRTPPVWSELAEGPDRTEDEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G9</accession>
    <name>A0A1E7N7G9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289701.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7920"/>
    <dbReference type="EnsemblBacteria" id="ARF79114">
        <property type="protein sequence ID" value="ARF79114"/>
        <property type="gene ID" value="B6264_09460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36584">
        <property type="protein sequence ID" value="OEV36584"/>
        <property type="gene ID" value="HS99_0029125"/>
    </dbReference>
    <dbReference type="OMA" id="AKYEPNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="22249" checksum="4143408BD9804BB3" modified="2017-01-18" version="1">MPATSPAPLTVGFDLDMTLLDTRPGIHATYRALSAETGTHIDADLVVTRLGPPLLDEIRNWFPEAEVERAVNRYRELYRDHAFAPTVPLPGARAAVEAVRAHGGRVAVITGKYEPNARLHLEHAGLEADTVIGDLWAETKGEALRANGASIYVGDHLGDIVGARHAEAVAVAVATGPYGADELRAAGADVVLADLTRFPEWLDRHLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N851</accession>
    <name>A0A1E7N851_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282018.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6459"/>
    <dbReference type="EnsemblBacteria" id="ARF78677">
        <property type="protein sequence ID" value="ARF78677"/>
        <property type="gene ID" value="B6264_06895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36876">
        <property type="protein sequence ID" value="OEV36876"/>
        <property type="gene ID" value="HS99_0026790"/>
    </dbReference>
    <dbReference type="OMA" id="MLRSPML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27029" checksum="7D564C825D53FE94" modified="2017-01-18" version="1">MASFPAILRSEWTKIRSVRSTVWTLALAFVVTVGIGALLSLLTNNNFTEFRRHDQSPFDATGTAFSGIMLGELAIIVFGVLAIGNEYSSGMIRATLAAVPQRGTLLAGKTVVLGALALAVSLVTAFVTFFVGQALLGSHSTSLSEPNVLRAVLGAALYLTMICLFSAGVTAMLHNQTLALGVLVPFFFLLSPILSAVPKVKTLAHYFPDYAGSRMLLVYEQNGQPYGPWAGFTICLAWTVAALVGGALVLKSRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N884</accession>
    <name>A0A1E7N884_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36910">
        <property type="protein sequence ID" value="OEV36910"/>
        <property type="gene ID" value="HS99_0026990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="17307" checksum="C01B5E7FDA4CA0AB" modified="2017-01-18" version="1">MFANSGGGEMPTGWWGLRGATAGAAEAAEEGVRAAGCAAVGALDDAGGGRLRAGPFGGHLVEQTAAGEGRRAVDAVRREACGESGGEEGGGGAPGQPFGGERFEGRAVGGGEGEAGVGKAETGERRVRGEVGEVRLSVRSLGGSGAPDVDASPASDASPVVRNCVHHASERGVREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q1</accession>
    <name>A0A1E7N8Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388261.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4841"/>
    <dbReference type="EnsemblBacteria" id="ARF83145">
        <property type="protein sequence ID" value="ARF83145"/>
        <property type="gene ID" value="B6264_29260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36843">
        <property type="protein sequence ID" value="OEV36843"/>
        <property type="gene ID" value="HS99_0027750"/>
    </dbReference>
    <dbReference type="OMA" id="TLTHQWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="29199" checksum="2DE658E16F617CB0" modified="2017-01-18" version="1">MFVHLTATANTPRIRRTGIRADSRGQGGVRGVYCFPVLPSYTLTHQWLRELARFGPKGSLAAVHVRLDDAQQVLVGHYRDRAEEAQRWLTAAEAVARIAALPDPRGWEVVVPRAVDAREVHRVRAVPQVAGWRYLPGAHGTRPCTCFGCRIRGEYGGRRLRERHPHPLDGPPPAVPVLLARIEAAGEPGDPDTLRAALHWFGLRRRGPLERLTPLAAHPDPTVRRELVWAVQGWSTPGVADLLDGLAADPHLDVREAVEDVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U5</accession>
    <name>A0A1E7N8U5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37117">
        <property type="protein sequence ID" value="OEV37117"/>
        <property type="gene ID" value="HS99_0004675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="6817" checksum="7EB1D1877734E661" modified="2017-01-18" version="1">MTPVTGITRAKPATPATGTSCVSICSVPYALELMQSGASTPNATGFDSFSARSCAVTSGGPSSNLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N951</accession>
    <name>A0A1E7N951_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556537.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6152"/>
    <dbReference type="EnsemblBacteria" id="OEV37209">
        <property type="protein sequence ID" value="OEV37209"/>
        <property type="gene ID" value="HS99_0005225"/>
    </dbReference>
    <dbReference type="OMA" id="MRNTKKP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="29399" checksum="FD1C2C5B349F86F1" modified="2017-01-18" version="1">MTVLITGARGRVGRAALDRLHAAGLPVRAASAEPAELAVPAGVATAELVLDRPETFPAALDGVQQVFLYPKPEGIGAFTEAARTAGVEHVVLMSSASVNAPDAETHPLAAHHLHVEQALTASGLPCTFLRPDAFASNALGWAHPISQGLPVQLAYPDAHIAPIHPDDIADIAVEAFTGAAFRGLAVTLTGARSLTFREQLGILAEVLGREVAVETVTRAEAEQQMARFMPPVVVGSLLDFWAAACAGPATIADTTETLLGTPARSFRQWAVENAAAFALSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B2</accession>
    <name>A0A1E7N9B2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556123.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000394.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7438"/>
    <dbReference type="EnsemblBacteria" id="ARF81666">
        <property type="protein sequence ID" value="ARF81666"/>
        <property type="gene ID" value="B6264_24640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37063">
        <property type="protein sequence ID" value="OEV37063"/>
        <property type="gene ID" value="HS99_0004355"/>
    </dbReference>
    <dbReference type="OMA" id="HRDESDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025629">
        <property type="entry name" value="DUF4287"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14117">
        <property type="entry name" value="DUF4287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10410" checksum="C7FC588A7241E97B" modified="2017-01-18" version="1">MSFQAYLDTIETKTGLTPRQFVALAAERGFDDPSTKAGVILTWLKEDYGLGRGHGMALVHVFKHGAKIDAKHVGTTGSHRDASDTLWLDGKATRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C8</accession>
    <name>A0A1E7N9C8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0005585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366203.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1298"/>
    <dbReference type="EnsemblBacteria" id="OEV37268">
        <property type="protein sequence ID" value="OEV37268"/>
        <property type="gene ID" value="HS99_0005585"/>
    </dbReference>
    <dbReference type="OMA" id="NIAHVAN"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1460" mass="157954" checksum="A4358DFF6D59FC5E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P4</accession>
    <name>A0A1E7N9P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558416.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000509.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000133_gene706"/>
    <dbReference type="EnsemblBacteria" id="ARF82502">
        <property type="protein sequence ID" value="ARF82502"/>
        <property type="gene ID" value="B6264_29790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37388">
        <property type="protein sequence ID" value="OEV37388"/>
        <property type="gene ID" value="HS99_0006315"/>
    </dbReference>
    <dbReference type="OMA" id="QFSYDRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22055" checksum="B0A8D180A762B9EA" modified="2017-01-18" version="1">MSERSKFLEPITRENAAVVLVDHQVGLLSGVRDIPLGELKHNVVALARAATVLGIPLVVTTTAADSMWGPTAPELVQVLPAGQKIIDRSTVNAWHDDRVREAIKATGRQKLVFARVSLEVCAALPAISATAAGYDAYVVVDASGTFSQAKRETGLLRMQQAGVIVSDYATLMVEALADNAAPEAATLYTALDMPFAVLVDQISAAHPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA32</accession>
    <name>A0A1E7NA32_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552363.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1146"/>
    <dbReference type="EnsemblBacteria" id="ARF79025">
        <property type="protein sequence ID" value="ARF79025"/>
        <property type="gene ID" value="B6264_08925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37546">
        <property type="protein sequence ID" value="OEV37546"/>
        <property type="gene ID" value="HS99_0026430"/>
    </dbReference>
    <dbReference type="OMA" id="HLTSTWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="371" mass="40004" checksum="7CDE2052CE3B958B" modified="2017-01-18" version="1">MKLTGTPFLVLAILLVPLSMGLLMYLWNRVRGPQPVRFGSRLLMVAFAQLTAVTLVFVVVNNDNQLYGSWDDLLGTGSHVRTVPVPPPADATAAANAPGQPKVTQQFTSVDDKAVPKDVRTTELKGRVSGVDGEVLVWTPPQYDDPAYKDRKFPVVELLVGFPGSSSAWFGSMNVSRQLAPLMKSGQVAPFILVSPRVVLLEGHVDTGCADVPGKVNAETWLARDVPQMVLDNFRAEPGPERWAVAGYSAGGHCAARLALAHPNRYHAGVSLSGYNDPMGESDSLTAKDPHLREVSNPVYLLQHAQTPPDVALYMTGRKGDGYEDALALQKNAKAPTAVTPVEVNGPHLTSTWEPLVPQVFTWLTQTVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA88</accession>
    <name>A0A1E7NA88_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">HS99_0025170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284182.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8020"/>
    <dbReference type="EnsemblBacteria" id="OEV37607">
        <property type="protein sequence ID" value="OEV37607"/>
        <property type="gene ID" value="HS99_0025170"/>
    </dbReference>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="69"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30989" checksum="DDF470329E265644" modified="2017-01-18" version="1">MHSRHNGLRTAVLLGGLSALILVIGSFFGRTGFVVALLVALGTNAYAYWNSDRIALRAMRARPVSEFEAPGLYRIVRELSTSARQPMPRLYISPTPAPNAFATGRNPRNAAVCCTEGILQILDDRELRGVLGHELSHVYNRDILISSVAGALASVVMFLVNFAWLIPFGRSEDDDGPGLFGMLAIMILGPIAAGLIQMAVSRSREYQADADGARSTGDPLALASALRKLDAGTRQLPLPPEPQLQTASHMMIASPFRPGEAGARLFSTHPPMAERIARLERMAGYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA97</accession>
    <name>A0A1E7NA97_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein HS99_0025225</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284153.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000498.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8008"/>
    <dbReference type="EnsemblBacteria" id="ARF79870">
        <property type="protein sequence ID" value="ARF79870"/>
        <property type="gene ID" value="B6264_14010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37617">
        <property type="protein sequence ID" value="OEV37617"/>
        <property type="gene ID" value="HS99_0025225"/>
    </dbReference>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18050" checksum="D5F6BFA1533AF2C3" modified="2017-01-18" version="1">MADSSFDIVSKVEWQEVDNAINQTSREIATRFDFKGVGGEISRSGEKIEMKANGEERVRAILDVLQTKFVKRGLSLKALDAAEPQLSGKEYKIFANIKEGITTEDAKKVAKIIRDEGPKGVKAQVQGDELRVSSKSRDDLQTVQALLKGKDLDFAIQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAA5</accession>
    <name>A0A1E7NAA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551546.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000498.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8009"/>
    <dbReference type="EnsemblBacteria" id="ARF79869">
        <property type="protein sequence ID" value="ARF79869"/>
        <property type="gene ID" value="B6264_14005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37616">
        <property type="protein sequence ID" value="OEV37616"/>
        <property type="gene ID" value="HS99_0025220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="20017" checksum="3E6B783A7519F7AE" modified="2017-01-18" version="1">MRATRMAALLTAALALTMVATVSATAADHGAAASRSTVAAPTAAVLPVVPVTVPAPPTTLPAADPALPGLPVGQADEPAVPTLPAVPGAPADPTLSALPTLPAVPAAADPSTAPLGAVGDLVKQITGLISTVTSTVPELGGAVQQLVASLQSLLQKLIGQLQPMATPANAPAPSAQPGSASAGLPGQLDALRAQAQALAAAAQLRPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG5</accession>
    <name>A0A1E7NAG5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="8" type="ORF">HS99_0025490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014144289.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1696"/>
    <dbReference type="EnsemblBacteria" id="ARF79915">
        <property type="protein sequence ID" value="ARF79915"/>
        <property type="gene ID" value="B6264_14280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37658">
        <property type="protein sequence ID" value="OEV37658"/>
        <property type="gene ID" value="HS99_0025490"/>
    </dbReference>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13786" checksum="CEA5006485F42534" modified="2017-01-18" version="1">MPTIQQLVRKGRQDKVEKNKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGIEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG9</accession>
    <name>A0A1E7NAG9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name evidence="4" type="ORF">HS99_0025605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030232481.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1673"/>
    <dbReference type="EnsemblBacteria" id="ARF79938">
        <property type="protein sequence ID" value="ARF79938"/>
        <property type="gene ID" value="B6264_14395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37681">
        <property type="protein sequence ID" value="OEV37681"/>
        <property type="gene ID" value="HS99_0025605"/>
    </dbReference>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13450" checksum="BC1D901D08A29612" modified="2017-01-18" version="1">MIQQESRLRVADNTGAKEILCIRVLGGSGRRYAGIGDVIVATVKDAIPGGSVKKGDVVKCVVVRTVKERRRPDGSYIRFDENAAVVLKNTEGDPRGTRIFGPVGRELRDKKFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR2</accession>
    <name>A0A1E7NAR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558319.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78093">
        <property type="protein sequence ID" value="ARF78093"/>
        <property type="gene ID" value="B6264_03425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37772">
        <property type="protein sequence ID" value="OEV37772"/>
        <property type="gene ID" value="HS99_0024575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13568" checksum="238C34FCD01ED137" modified="2017-01-18" version="1">MNHTQQISTDIKSDTTTIPTQEQESEAEPLEVATKDTFFVKTPESAEASFTLSHTGAEGKVKVPEASADKLINGMGELATLAATPVGILAIIKYAKGSGMPAGILSAAVLVLASALATIVVARTLRRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW5</accession>
    <name>A0A1E7NAW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557067.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000662.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3751"/>
    <dbReference type="EnsemblBacteria" id="ARF78057">
        <property type="protein sequence ID" value="ARF78057"/>
        <property type="gene ID" value="B6264_03210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37808">
        <property type="protein sequence ID" value="OEV37808"/>
        <property type="gene ID" value="HS99_0024780"/>
    </dbReference>
    <dbReference type="OMA" id="CNSWSLE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="27713" checksum="EC2369087BC26C84" modified="2017-01-18" version="1">MADQTLFAAQRRALILEEIRRTGAVRVADLVTEFGVSDMTVRRDLEALTRQGAVQKVHGGAVAAGSASSFEPGFTAKSELEEGTKAALADAAARLVEPGSVVALSAGTTTYAVASRLLEVPQLTVVTNSLRIADLLWAAESDGRETVPSLLLTGGSPTRSAALVGALADQLIRTLHVDLLILGVHGVSEQAGLTTPNLAEAQTNRALIASARRTVVVADHTKWGVVGLSSFAPLTEVDCFITDDALPAAARTALADTVGELVVVPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW8</accession>
    <name>A0A1E7NAW8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289172.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6030"/>
    <dbReference type="EnsemblBacteria" id="ARF78033">
        <property type="protein sequence ID" value="ARF78033"/>
        <property type="gene ID" value="B6264_03045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37831">
        <property type="protein sequence ID" value="OEV37831"/>
        <property type="gene ID" value="HS99_0024940"/>
    </dbReference>
    <dbReference type="OMA" id="FDVAFGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="25566" checksum="96EB849E03C53660" modified="2017-01-18" version="1">MNLSPKKRLAAAFALGAATVLAAAVPASAHVIVQPNSVPKNATDQTFAFRVPDEDDKNSTVKVEIDFPTDHPIPSVKVAPVPGWTDAIQTTKLATPIHTDDGDITDAVSQVVWTGGQIAPGHFQDFTVDLGALPDGTDKVVFKALQTYSDGTVVRWIEEPQDGQPEPKNPAPVLKLTAATAGDSDAPAPGAAASAKADPAPANPTSTATAKASGSDSTARALGIAGIVVGVLGAVAGVVIGRRGRGTGADASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB20</accession>
    <name>A0A1E7NB20_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crgA</name>
        <name evidence="2" type="ORF">HS99_0023720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278238.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2133"/>
    <dbReference type="EnsemblBacteria" id="ARF79442">
        <property type="protein sequence ID" value="ARF79442"/>
        <property type="gene ID" value="B6264_11385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37892">
        <property type="protein sequence ID" value="OEV37892"/>
        <property type="gene ID" value="HS99_0023720"/>
    </dbReference>
    <dbReference type="OMA" id="WNIVVGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="9126" checksum="2C0131C176BF788D" modified="2017-01-18" version="1">MPKSRLRKKSDYTPPTTAAVKISSGRGWVAPLMLALFLIGLVWIVTYYVTSGSFPVESWRNWNILVGFGFIAAGFGVSTQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB96</accession>
    <name>A0A1E7NB96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366684.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2027"/>
    <dbReference type="EnsemblBacteria" id="OEV37976">
        <property type="protein sequence ID" value="OEV37976"/>
        <property type="gene ID" value="HS99_0024255"/>
    </dbReference>
    <dbReference type="OMA" id="WHLATPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="35633" checksum="D9721EDE5910CDA0" modified="2017-01-18" version="1">MTAEPAVTPHQVPENGEPDEAARQLYLAIIAEGGRIPFADITDDDGAALRQLLDIGLIMVNRMDRCYTAVSPRSVSDRLGAELRSEATRLLVRAENLPGALDGLTRAYDAMPRPSGGSGGAVHVEGHVHIRQRISQLVSDCRSEVLTAQPGQRPADALQVALAQDIRLLQRGCSLRTIYQPVALADPPAIAYAEEVTRHGSQIRILDEPFQRLIVFDRSVAVISANDDNSAAAFISDPAALTFLIGGFERDWTRADTAEAASALGRGPARTIPDRIGRLLARGLTQRAVATRLGLSERTVAGHISRLRDRYGAQTLFHLGWHLNGERHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC7</accession>
    <name>A0A1E7NBC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278413.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000265.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2010"/>
    <dbReference type="EnsemblBacteria" id="ARF79548">
        <property type="protein sequence ID" value="ARF79548"/>
        <property type="gene ID" value="B6264_12030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37992">
        <property type="protein sequence ID" value="OEV37992"/>
        <property type="gene ID" value="HS99_0024350"/>
    </dbReference>
    <dbReference type="OMA" id="YTAVSWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="18188" checksum="8CA3C73D6547BC92" modified="2017-01-18" version="1">MKKTSVRARVLTGTAAVAALAAAGVGAVSASAETTDTPAAPAAVKVDTQNKNLAQSTGLNIDAATRAAQAALDAANKAGQHVSVAVVDRDGVTRVLLKGDGAGPQATESAERKAFTAVSWNAPTSELAKRLAQAPNLKDIPGTLFLAGGAPAQSKGAPVAGIGVAGAPSGDLDEQFAQAGVAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF8</accession>
    <name>A0A1E7NBF8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284413.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8137"/>
    <dbReference type="EnsemblBacteria" id="ARF79760">
        <property type="protein sequence ID" value="ARF79760"/>
        <property type="gene ID" value="B6264_13365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38030">
        <property type="protein sequence ID" value="OEV38030"/>
        <property type="gene ID" value="HS99_0022745"/>
    </dbReference>
    <dbReference type="OMA" id="QMQEISN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="52190" checksum="385730A8675D159D" modified="2017-01-18" version="1">MSTETNAGIPAPGAQPDIRQQQSLSTAGARNLATTTKSAPQMQGISPRWLLRTLPWVQVSGGTYRVNRRLRHKVGRGRVSFVKTGSEVRIVPQTLAEVPVLRGYEDEAVLEELAGRFVQRQFQAGDVLVTAGTPISEVFLIAHGKLERLGTGKYGEETVVGTLADGDHLGDEALQEEDGSWPYTVRAATAGTVMVLAWPSFQELHDRSESLQLQIMEYLNGFQQAQNKHGEAAIDLSAGHQGEYELPGAFVDYELKPREYELSVAQTILKVHTRVADLYNKPMNQTEHQLRLTIEALRERQEHELINNPEFGLLENAEYDQRIQTHSGPPTPDDMDELLSRRRSTKMFLAHPKAIAAFGRECNKRGLYPGTVEVEGKQVSAWRGVPIFPCNKIPIVGGSTSSILAMRVGEDNQGVVGLHQTGIPDEYQPSLSVRFMGIDEKAIISYLVSAYYSAAILVPDAVGVLENVDIAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU3</accession>
    <name>A0A1E7NBU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0023290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389450.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5932"/>
    <dbReference type="EnsemblBacteria" id="ARF79667">
        <property type="protein sequence ID" value="ARF79667"/>
        <property type="gene ID" value="B6264_12805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38124">
        <property type="protein sequence ID" value="OEV38124"/>
        <property type="gene ID" value="HS99_0023290"/>
    </dbReference>
    <dbReference type="OMA" id="FLPAFVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="19838" checksum="68DCD10CEA1F7EC1" modified="2017-01-18" version="1">MVSAVGAGLAVAVLVGDVVGVVAGGLAAAGVHRWSARARSPTDRRAALEEELLTRQLPLGAELLAACLGSAALPSVAVSAVGRSVGAPLGPRLVAIGAELALGAPPELCWTRLGEQHPALAPLARCLVRTSLGGAPVAGPLIGLAQAQRTAAARAAHTRVRRAAVLATAPLGLCFLPAFVLIGVVPVVIGLTSRFAQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC69</accession>
    <name>A0A1E7NC69_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290727.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000650.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1747"/>
    <dbReference type="EnsemblBacteria" id="ARF80236">
        <property type="protein sequence ID" value="ARF80236"/>
        <property type="gene ID" value="B6264_16130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38248">
        <property type="protein sequence ID" value="OEV38248"/>
        <property type="gene ID" value="HS99_0022150"/>
    </dbReference>
    <dbReference type="OMA" id="DDTLWVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="25659" checksum="CD58B48A5B77A7BC" modified="2017-01-18" version="1">MHTDQTLIFDADDTLWENNVLFERVIAGFLDWVATPVEREATRTLLDRIEAANAAALGYGATVFRQSLADCLRQLNDDRTPTEAELARIDELLAPLTRRGEVELITGVADTLTALAGRHHLLLLTKGDQEEQQAKVTASSIDHHFRGIHIVAEKSVDTYRQLTTELGLDPDRTWMIGNSPKSDIAPARRAGLRTVFIPHEHTWVLEHVDLGPDEATLQLTAFPELLRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI3</accession>
    <name>A0A1E7NCI3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="2" type="ORF">HS99_0021055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283205.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000707.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene267"/>
    <dbReference type="EnsemblBacteria" id="ARF82208">
        <property type="protein sequence ID" value="ARF82208"/>
        <property type="gene ID" value="B6264_28000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38402">
        <property type="protein sequence ID" value="OEV38402"/>
        <property type="gene ID" value="HS99_0021055"/>
    </dbReference>
    <dbReference type="OMA" id="GTYMHGP"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26128" checksum="FF507E8E1B66A56E" modified="2017-01-18" version="1">MSESSLRVVWVYPDLLSTYGDRGNALVVERRARQRHLNVTRIDVRSDQAIPTSGDIYLIGGGEDRPQRLAAERLRADSGLVRAAENGAIIFGVCAGFQIMGHEFVNDLGEREQGLGLLDVWTTRGEGARCVGDVLADIDPRLGLPQLTGFENHQGVTHLGQGVQPFATVTVGRGNGTGDGTEGAWRDTVFGTYMHGPVLARNPAVADMLIRLALDVNALPPADTTWYDALRAERIAATTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCV1</accession>
    <name>A0A1E7NCV1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288348.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3108"/>
    <dbReference type="EnsemblBacteria" id="ARF82091">
        <property type="protein sequence ID" value="ARF82091"/>
        <property type="gene ID" value="B6264_27310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38512">
        <property type="protein sequence ID" value="OEV38512"/>
        <property type="gene ID" value="HS99_0021735"/>
    </dbReference>
    <dbReference type="OMA" id="ESRAMNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="494" mass="50808" checksum="35C77D90931BFB51" modified="2017-01-18" version="1">MSEAPQPTTAAEKQSNARVLPALILAMLSFSVVQTAVVPILPSLAKELDVSGSNITWLMTANLLSAAVLTPLLGRFGDLRGRKPMLLISLAGLVAGSALAVSTHSFTWLVVARVLQGAGGGVMPLAISIVRDELPKQKVTGGVAAISASMGVGSGLGLVATGLLLEHWNYKSIFWMGLVFGLIAVALVAFRVPTDPVTDKEGGADPIGALALAAWLSALLVAVSQGNHWGWTSTKTLGLFAVAAVVALVWGVIETKVSHPLVDLKMMSRPAVAFTNLSGLLIGFGMYGSFMVISNFAQTPEKYAHYGFTATVLHAGVMLLPSAIGSMVAAPVGALLIARRGPRLPLVLGGVLGAVSMAYLALRHSHEGDIYTASAIFGLGIGLAFAAMPAFINGAVPVEQSGIANGMNSVLRTVGGAIGTAVMTAILTGDVMKLPIPVLLPTLDAYKHAFWTTAVVCVIAGAVPFLIRTVKSAPAVADGSAPQDSSPQLAKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCV5</accession>
    <name>A0A1E7NCV5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">HS99_0021725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598424.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3106"/>
    <dbReference type="EnsemblBacteria" id="ARF82093">
        <property type="protein sequence ID" value="ARF82093"/>
        <property type="gene ID" value="B6264_27320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38511">
        <property type="protein sequence ID" value="OEV38511"/>
        <property type="gene ID" value="HS99_0021725"/>
    </dbReference>
    <dbReference type="OMA" id="CVPMSEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="966" mass="102421" checksum="617BB310F01926E4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY4</accession>
    <name>A0A1E7NCY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551536.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene702"/>
    <dbReference type="EnsemblBacteria" id="ARF77568">
        <property type="protein sequence ID" value="ARF77568"/>
        <property type="gene ID" value="B6264_00290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38545">
        <property type="protein sequence ID" value="OEV38545"/>
        <property type="gene ID" value="HS99_0019875"/>
    </dbReference>
    <dbReference type="OMA" id="FMIKQRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046306">
        <property type="entry name" value="DUF6421"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19985">
        <property type="entry name" value="DUF6421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="466" mass="52193" checksum="B14DCAA6A9D468EC" modified="2017-01-18" version="1">MQNLSPRLAAAADAPVSTLAAHPAWLRLKEAVERLRPLQSKDGSIDLSAVQRQTVDPLVATVRASVEELAPNFPHDAAYLAAVDADLAKWADTGYREPDFLDSLLAFQPAEQREDGLEHLVVFPMYTQNGNPDRNLEAVLLSVVWPEWLDELERTRFDNPMFVPITFTDFTAGYDTNSAVLFPETVAVRKAPERFTWGGIFCDREAARFRAVSTSAIDQLGLEIPADAEGLLKDQHRAQETFVLWDLVHDRTHSHGDLPFDPFMIKQRSPFWMYGLEELRCDLTTFKEAVKLEAEGNPHARDVQYAILFDRLFRFPVSGDRVRNYDGLGGQLLFAYLHKHDALRWRDNRLTIDWDRAPQVTNALCGEIETLYRDGIDRPKPAHWIAAYELVSRYLTPHPASTWAKGPEALPLDITDGKALNKALCDAVLPDEFPLSMFYEALSKKLRGVIAATAGITGAGIQGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ9</accession>
    <name>A0A1E7NCZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3082"/>
    <dbReference type="EnsemblBacteria" id="OEV38538">
        <property type="protein sequence ID" value="OEV38538"/>
        <property type="gene ID" value="HS99_0021605"/>
    </dbReference>
    <dbReference type="OMA" id="TAFDKWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="2">
        <location>
            <begin position="309"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="420" mass="43625" checksum="E17F102D8A492116" modified="2017-01-18" version="1">MAEGAVAALAEETLDWRFKAAPPESWGHTVRDWLATGPTLSSLGTPLLTLDGAALDHNVRTMADWCAKAGVALAPHGKTTMAPELWQAQLAAGSHGITLANLPQVRVARAFGVQRILLANTLLDPAGLAWLAAELAADPGFAFLCWTDSSEGVRLMDEALRAAGAERPVEVLVELGGPGGRTGARGVDAAVEVAAAVLRAPTLRLAGVGGYEGALAHDATTEGLATVRGYLKALGELHGRLADAYPDGVPPVVSAGGSAYFDLVVDELAALPEALVVLRSGAYIAHDDGFYRGISPLVRGGGDTPFRGALHGWARVASRPEPQLALLDAGKRDLPFDDGLPEPQLVRGGARLTGAAARITALNDQHAFLRDAGDLAPIGAVLRLGVSHPCTAFDKWTAIPVLDSADAAEPKVTGLVRTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE8</accession>
    <name>A0A1E7NDE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Teichoic acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551491.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene646"/>
    <dbReference type="EnsemblBacteria" id="ARF82534">
        <property type="protein sequence ID" value="ARF82534"/>
        <property type="gene ID" value="B6264_00570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38707">
        <property type="protein sequence ID" value="OEV38707"/>
        <property type="gene ID" value="HS99_0020155"/>
    </dbReference>
    <dbReference type="OMA" id="VHIVYRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="28219" checksum="D8EF257D686FDC9E" modified="2017-01-18" version="1">MIKRDAVPAVSVAREPTVVVDDVHIVYRVHGAGSGKGSATSAMSRILSRKRGAGVREVHAVKGISFTAYKGEAIGLIGSNGSGKSTMLAAIAGLLPTEKGGIYTNGQPSLLGVNAALMNELTGERNVILGCLAMGMTPAQVKERYQEIVDFSGINDKGDFISLPMRTYSSGMGARLRFSIAAAKTHDVLLIDEALATGDQAFQQRSKRRIDELRGSAGTVFLVSHDNNSIREVCERTIWIEAGELVMDGPTDEVVGRYERGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDM3</accession>
    <name>A0A1E7NDM3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7353"/>
    <dbReference type="EnsemblBacteria" id="ARF81172">
        <property type="protein sequence ID" value="ARF81172"/>
        <property type="gene ID" value="B6264_21740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38764">
        <property type="protein sequence ID" value="OEV38764"/>
        <property type="gene ID" value="HS99_0019010"/>
    </dbReference>
    <dbReference type="OMA" id="NPRICRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="32148" checksum="DC6392088495C18F" modified="2017-01-18" version="1">MAKERRTEQPARLASKPYERELLRLQQELVKLQEWVRVEGARLVVVFEGRDAAGKGGAIKRVTEYLNPRIARVAALPTPTERQKTQWYFQRYVEHLPAAGEIVLFDRSWYNRAGVERVMGFCTADEYWQFLHQCPTFEQMLIEAGILLRKYWFSVSDTEQERRFRDRLEDPMKRWKLSPMDVESITHWEDYSRAKDEMFVHTDVPQSPWHVVESDDKRRARINMIAHLLSSVPYREVAPPRIELPPRPSSRGYQRPPRDLQKYVPDHAAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT8</accession>
    <name>A0A1E7NDT8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">HS99_0019200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030240625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7392"/>
    <dbReference type="EnsemblBacteria" id="ARF81206">
        <property type="protein sequence ID" value="ARF81206"/>
        <property type="gene ID" value="B6264_21935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38798">
        <property type="protein sequence ID" value="OEV38798"/>
        <property type="gene ID" value="HS99_0019200"/>
    </dbReference>
    <dbReference type="OMA" id="QHADSKY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9532" checksum="6E619F0492CAEAB9" modified="2017-01-18" version="1">MSSSMTAPEGIINPPIDELLEATDSKYSLVIYAAKRARQINAYYSQLGEGLLEYVGPLVDTHVHEKPLSIALREINAGMLTAEAIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU3</accession>
    <name>A0A1E7NDU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6497"/>
    <dbReference type="EnsemblBacteria" id="ARF81272">
        <property type="protein sequence ID" value="ARF81272"/>
        <property type="gene ID" value="B6264_22325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38867">
        <property type="protein sequence ID" value="OEV38867"/>
        <property type="gene ID" value="HS99_0019590"/>
    </dbReference>
    <dbReference type="OMA" id="LAPWFGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="532" mass="56455" checksum="2BC01E79938AEF38" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU6</accession>
    <name>A0A1E7NDU6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0019460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556325.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5126"/>
    <dbReference type="EnsemblBacteria" id="OEV38844">
        <property type="protein sequence ID" value="OEV38844"/>
        <property type="gene ID" value="HS99_0019460"/>
    </dbReference>
    <dbReference type="OMA" id="IGNVFRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="229"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="47305" checksum="58543A88D04FAC2C" modified="2017-01-18" version="1">MRGALARFAFAVATMVALAFLIPLALTVREFARDRAFAEAERQAAAIEPVLVVTTDQVALTRALASTPVGAAGRIAVHLPSGAVIGTAHAGGEQFDTAVRQGRAFTARVAGGYAVLQPVVLDPGSVAVVEVYLLDGDLRRGLGTVWSVLGGVAVVLITLSSLVADRLAARLVGATRHLAGAARTLGAGNLDVRVDAQGPYELREVGLAFNAMAGRMVQMITAEREFAADLSHRLRTPVTALRLNAAALDGGPVADQTRQVVAWLEREVDLVINTARAGGAGREAAECDAADVLAERMAFWSALAEDQERRWHFSGPGEPVPVPVAQSEFAAAVDAALGNVFRHTGEGTEFSVTLHAGNGTAVILVADAGPGISAPEVALRRGQGTRREGSTGLGLDIVRRMAEGAGGGMRIERSALGGAQVHIWLPSGAGAARTTGTSSDAAPAARRRGGRRAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE33</accession>
    <name>A0A1E7NE33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmid stabilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6512"/>
    <dbReference type="EnsemblBacteria" id="OEV38932">
        <property type="protein sequence ID" value="OEV38932"/>
        <property type="gene ID" value="HS99_0019665"/>
    </dbReference>
    <dbReference type="OMA" id="VGQCKPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199041" evidence="2">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="90"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="43458" checksum="E47FC6E506CD6A73" modified="2017-01-18" version="1">MTAAALALTGCSSATAPSSDAHHPDGTVVRVPQDFPSVQKAVDVAREGDTVLVSPGTYRESVRITKPRIVLRGTDRNTVVLDGGVRLVNGVTVTGPGSVVENLTVHGYLANGVLFTGVTDEKLQQRGAGGSAYNPLDTTRFPALQGFRATRVTAYDNGLYGIYAFDARAGIVEDSYASGGADSGIYVGQCKPCDTLVRGNTVERNAVGIEITNASDNLHFLGNRVVGNRVGVTVNSNDLEALAPQHGAVIAGNSVTDNNASDTPEQADGGFGIGIGIGGGTANRVERNLVRGNRSAGVIITDPPGHPAGANRIQGNRTEGNGADLVLASADTGNCFSGNQPATQSPDGLESLAACDAQSRSPLTAGRAAPVQAPPGIPFNQVQAPPAQPSLPDPDAPGRPATDLPGPVDPDAYPLPATADAVPTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ7</accession>
    <name>A0A1E7NEJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557149.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39092">
        <property type="protein sequence ID" value="OEV39092"/>
        <property type="gene ID" value="HS99_0018580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16566" checksum="2E8AFC50E71EDEFB" modified="2017-01-18" version="1">MEPLGDQELGTAIENADSLAWSVRGAAGRQLASSDKIEEVADVLHRLLLDARNTWVIQETAEALLERKDTIGLRYVLLAYSQAGTHDAVDHLGAALDCNPEWMTTEGADRLIKQYRELAADPDASVRDEAQQVLAKLRPREEWARDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEP7</accession>
    <name>A0A1E7NEP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1030"/>
    <dbReference type="EnsemblBacteria" id="OEV39144">
        <property type="protein sequence ID" value="OEV39144"/>
        <property type="gene ID" value="HS99_0018215"/>
    </dbReference>
    <dbReference type="OMA" id="ELADHHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="36382" checksum="4B578DB294357EDA" modified="2017-01-18" version="1">MRTAADESAEWLQWAEVANCGPVSVEQYAADARGFAADYLMAEDPLLIFGKTRASLVRVWELLYGHQNLEQRQKLFTTAGYLAAMMAWMTSDLGHKRQAETHARAAMVAAEMAADPGLHAWVAATRSKLAFWDGQFRAAIQHAEHGTVFQASGTVTVLLHCQAADAWAEVGARSQAKAALGRAEDAAALDLSSVIHDEVAGLFSCPAGRLANYGAAVHLRAGSPSQALAYADCGLAALQRQAVRPLGTVAQLHITRAGAHLLADEPDGILEALSPVLALPAEHRTAPVRQRLRDLARDAAGSPMGDSATGRRLQDVVETAVREAALALSLSAPTDGWISDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER8</accession>
    <name>A0A1E7NER8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285188.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3521"/>
    <dbReference type="EnsemblBacteria" id="OEV39206">
        <property type="protein sequence ID" value="OEV39206"/>
        <property type="gene ID" value="HS99_0000290"/>
    </dbReference>
    <dbReference type="OMA" id="PTGMYTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="54460" checksum="446194E1FCFDB742" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX8</accession>
    <name>A0A1E7NFX8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285748.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6716"/>
    <dbReference type="EnsemblBacteria" id="OEV39574">
        <property type="protein sequence ID" value="OEV39574"/>
        <property type="gene ID" value="HS99_0002525"/>
    </dbReference>
    <dbReference type="OMA" id="QGKTIPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199100" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="42"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21087" checksum="58A8A504E84272E8" modified="2017-01-18" version="1">MEPQPPGHDQASGVGRRRVLGLALGASIVPALGQAAQPAHAAGPSEPAAALGQRVAAVAAAQIGVPYAWGGGDRLGPGLGFCDQDNGYLNGVCLGESTVGFDCSGLSLYCWYRASHGTVELGHYTVAQFNRSAPVERDALAPGDLLFFSRPDAPLHHVGVYAGDGAMIHAERTGTLVARVEKVLDLPRWAGEFAGARRPAPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG77</accession>
    <name>A0A1E7NG77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279280.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2792"/>
    <dbReference type="EnsemblBacteria" id="OEV39648">
        <property type="protein sequence ID" value="OEV39648"/>
        <property type="gene ID" value="HS99_0002990"/>
    </dbReference>
    <dbReference type="OMA" id="DTRGQGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35493" checksum="E2ADE32AF4A8C101" modified="2017-01-18" version="1">MPLTDFGADELGDYQPESTIPQDFDEFWQRTLAEARSHGGAVKAERVTAQHGLRTVEVDDVRFPGWNGEPVAAWLLRPRGAAGPLPVVVTYLGYSGGRGLPTEHLFWSAAGYAQLVVDSRGQGHDTPDPATGDGTQWVGGFMTRGIDSPETYYYRRLMTDCVRAVDAVAEFPGLDTDRIVVAGVSQGGGLALAAAGLTGDRVAAVMPDVPFLCHYREGAQTALDGPYQELVNYLRWHSRHRVRPAFATLDYFDGVNFARRATAPALFSVGLMDPVCPPRTVYAAFNHYAGEDRTMTVWPFADHAGGCGSNPPVQLSWLRGRGLAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA9</accession>
    <name>A0A1E7NGA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550481.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000745.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2908"/>
    <dbReference type="EnsemblBacteria" id="OEV39740">
        <property type="protein sequence ID" value="OEV39740"/>
        <property type="gene ID" value="HS99_0003560"/>
    </dbReference>
    <dbReference type="OMA" id="CYFDNDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="28129" checksum="EE5A46248BA28980" modified="2017-01-18" version="1">MPLIVGTSGWQYDDWRGLLYREGTPKRRWLEEYAARFATVESNAAFYRLPSPDTFADWRARTPAGFVFAVKASRYLTHIRRLREPAEPVQRLLTAAQGLGDRLGPVLLQLPPTLHADAELLDRCLAAFPTGVRVAVEPRHPSWWTPEIRAVLTDRAAALCWADRESRPVTPLWRTCDWGYLRCHAGRARPRPRYGRQALATWVGRIADTWADPADVHVYFNNDPGGAAVLDATVFESTAARAGRTVARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC6</accession>
    <name>A0A1E7NGC6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACPS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2932"/>
    <dbReference type="EnsemblBacteria" id="OEV39761">
        <property type="protein sequence ID" value="OEV39761"/>
        <property type="gene ID" value="HS99_0003675"/>
    </dbReference>
    <dbReference type="OMA" id="PGCGGPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="3">
        <location>
            <begin position="136"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="26587" checksum="62DC6C265079289E" modified="2017-01-18" version="1">MNPFDVNPPDVSQPDRWPPGPAAPALAEDEVHVWRARLDPPEHATRRYAELLDPEERTRAGRCRLPVERARFVAAHGALRTVLARYTGRPPADLRLHRSARGRPGLTPAPHHAALDFNLSHSGDLALIAVTRTGTVGVDLEEVRADLDHRAMAARFLGPAEARLIAGLPPAAGRHAFYARWTWREAYAKAADLPVPRRLGPGAPGPLPITVDLWKLSNLPLDKGYCATVAASGSCAPPLRWTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM5</accession>
    <name>A0A1E7NGM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000659.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2897"/>
    <dbReference type="EnsemblBacteria" id="OEV39869">
        <property type="protein sequence ID" value="OEV39869"/>
        <property type="gene ID" value="HS99_0003510"/>
    </dbReference>
    <dbReference type="OMA" id="AANDCYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199148" evidence="4">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="14058" checksum="09C37B171B8316B4" modified="2017-01-18" version="1">MTRTLRAWKSRAAAVAVLSLATLAPVAVATEAHAAVSGKVCVSALPSQARTTLGLIAKGGPFPYRQDGVVFTNKEGVLPSQRSGYYHEYTVVTPGAPTRGTRRIVTGQRHQEDYYTSDHYATFRLIDFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q6UB13</accession>
    <name>Q6UB13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sai20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sai20</name>
        <name evidence="4" type="ORF">HS99_0005320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="1582" last="1585">
            <title>Isolation and purification of two novel streptomycete RNase inhibitors, SaI14 and SaI20, and cloning, sequencing, and expression in Escherichia coli of the gene coding for SaI14.</title>
            <authorList>
                <person name="Krajcikova D."/>
                <person name="Hartley R.W."/>
                <person name="Sevcik J."/>
            </authorList>
            <dbReference type="PubMed" id="9515932"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2003-08" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning of the gene of ribonuclease inhibitor SaI20.</title>
            <authorList>
                <person name="Krajcikova D."/>
                <person name="Hartley R.W."/>
                <person name="Sevcik J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="5" key="5">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="AY374310">
        <property type="protein sequence ID" value="AAQ83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37224">
        <property type="protein sequence ID" value="OEV37224"/>
        <property type="gene ID" value="HS99_0005320"/>
    </dbReference>
    <dbReference type="OMA" id="DAWSDTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAQ83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="104" mass="11800" checksum="3DC11D1D1E7458C9" modified="2004-07-05" version="1">MTDNELIVDLRGRQIETLNDFWDAVSEPCGLPEWFGRNLDAWSDTIETRGISEVIDSHDILVVHVDQRGLFEGHRREADVLADTFDGEQNQLIVHGPDWPAATD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-04-25" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>S4S3E3</accession>
    <name>CTCQ_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin reductase (NADH)</fullName>
            <ecNumber evidence="5">1.5.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ctcQ</name>
        <name evidence="7" type="ORF">B6264_18520</name>
        <name evidence="8" type="ORF">HS99_0013300</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2013" name="Metab. Eng." volume="19" first="69" last="78">
            <title>Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Cheng X."/>
                <person name="Liu Y."/>
                <person name="Deng Z."/>
                <person name="You D."/>
            </authorList>
            <dbReference type="PubMed" id="23800859"/>
            <dbReference type="DOI" id="10.1016/j.ymben.2013.06.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain evidence="6">F3</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>TAR cloning and integrated overexpression of 6-demethylchlortetracycline biosynthetic gene cluster in Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Hu H."/>
                <person name="Huang H."/>
                <person name="Min T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DM-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of flavin by NADH. Subsequently, the reduced flavins is transferred to the tetracycline 7-halogenase CtcP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:31303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60531"/>
            <dbReference type="ChEBI" id="CHEBI:62787"/>
            <dbReference type="EC" id="1.5.1.36"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the non-flavoprotein flavin reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.36" evidence="5"/>
    <dbReference type="EMBL" id="HM627755">
        <property type="protein sequence ID" value="AEI98660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP020567">
        <property type="protein sequence ID" value="ARF80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S4S3E3"/>
    <dbReference type="SMR" id="S4S3E3"/>
    <dbReference type="STRING" id="1894.JOER01000001_gene5208"/>
    <dbReference type="EnsemblBacteria" id="ARF80632">
        <property type="protein sequence ID" value="ARF80632"/>
        <property type="gene ID" value="B6264_18520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33528">
        <property type="protein sequence ID" value="OEV33528"/>
        <property type="gene ID" value="HS99_0013300"/>
    </dbReference>
    <dbReference type="KEGG" id="ag:AEI98660"/>
    <dbReference type="KEGG" id="kau:B6264_18520"/>
    <dbReference type="OMA" id="AGWIACH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036382">
        <property type="term" value="F:flavin reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000443995" description="Flavin reductase (NADH)">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q5SJP7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23800859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="23800859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="23800859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AEI98660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="ARF80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AEI98660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000192662"/>
        </source>
    </evidence>
    <sequence length="191" mass="19899" checksum="AD05CE24243EF35C" modified="2013-10-16" version="1">MPPEPLSLPLDLAPGLVDGDTFLSIMGALPTGVTVVTTLGPDGEPYGLTCSAACSVSKAPPLLLVCINRDSRVLKALLERGEFAVNVLRGGGESTSARFAAPVDDRFRDVRWEPGSAGGVPVMSADVVAHAECRVAAALDAGDHTIVIGAVVAGGPRPEVPSPLMYWRRSYARWPVEEDPRTAALTLAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV50</accession>
    <name>A0A1E7MV50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6886"/>
    <dbReference type="EnsemblBacteria" id="OEV32306">
        <property type="protein sequence ID" value="OEV32306"/>
        <property type="gene ID" value="HS99_0016495"/>
    </dbReference>
    <dbReference type="OMA" id="ACRPCMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="33274" checksum="ECD59A81DF5C7732" modified="2017-01-18" version="1">MTERPTLLVLRALGLGDLLTGVPALRALRRHHPGHELVLAAPARLAPALAATGTADRLLATDAPGREVPHRLPWDGPPPDLAVDLHGNGPASRDALARLRPARLIAYADAGAPRWRDDEHERERWCRLLRHHGIGADAGDLLIARPAVPSPAPGAVLIHPGADAAARQWPLGHRVVVTAGRGERALAEGVACEAGLPSGDVLGGATDLPFPLLAALVAEARAVVCGDTGIAHLATALGTPSVTLFGPVSPVLWGPPAVPRHLALWRHHGEETRPGDAHGPRPDPRLLRIRPADVLAALAELSLPPPVPLPGCGAPVRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVF1</accession>
    <name>A0A1E7MVF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553906.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7011"/>
    <dbReference type="EnsemblBacteria" id="OEV32410">
        <property type="protein sequence ID" value="OEV32410"/>
        <property type="gene ID" value="HS99_0017110"/>
    </dbReference>
    <dbReference type="OMA" id="HGMKLMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198563" evidence="2">
        <location>
            <begin position="36"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="627" mass="66416" checksum="D47A7AC49CE7DF9D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVH5</accession>
    <name>A0A1E7MVH5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7516"/>
    <dbReference type="EnsemblBacteria" id="OEV32424">
        <property type="protein sequence ID" value="OEV32424"/>
        <property type="gene ID" value="HS99_0017200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198464" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="7978" checksum="EC02A295EB73912B" modified="2017-01-18" version="1">MTAPVMPRHLRPRVALLSTLPVLAVAAVVLPPPAAAGLLPWSLLPAVALAQGVRAWLVSRRLGRADDGGGPGATSRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS4</accession>
    <name>A0A1E7MVS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291189.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32524">
        <property type="protein sequence ID" value="OEV32524"/>
        <property type="gene ID" value="HS99_0017135"/>
    </dbReference>
    <dbReference type="OMA" id="YHMPFPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="54"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="32059" checksum="B5C7B3FC1AA21D23" modified="2017-01-18" version="1">MQRIGLGDAEIIRILEWQGAFAPAGRIVPEPAEAAWRRAGPDHYDPASGSYLGALQTWVVRTGAHTVVVDTGVGDDRERPDTPLFHRRKGRFLDLLAEAGIRPEDVDVVVNTHLHADHVGWNTRDRQGSWVPSFPNAVYHLPAADLAFFDPGAAHPARTDDSVDPARWAEWDRVFADSLAPVLAAGQAAPWSGTRTIGTGLVLQEAPGHTPGSSVLRLTSGGEHAVFVGDLLHSPVQLANPGCSSCFCLDQEQAAASRLRILRQAADRRELVLPAHFAGPGAARVERAGAGFVPRWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS5</accession>
    <name>A0A1E7MVS5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0017165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7523"/>
    <dbReference type="EnsemblBacteria" id="OEV32525">
        <property type="protein sequence ID" value="OEV32525"/>
        <property type="gene ID" value="HS99_0017165"/>
    </dbReference>
    <dbReference type="OMA" id="TPWARLY"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012728">
        <property type="entry name" value="NRPS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02353">
        <property type="entry name" value="NRPS_term_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="829"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="492"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1279"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1304" mass="137850" checksum="D2CF05DD9FDAD865" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW09</accession>
    <name>A0A1E7MW09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287891.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000432.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3837"/>
    <dbReference type="EnsemblBacteria" id="ARF78342">
        <property type="protein sequence ID" value="ARF78342"/>
        <property type="gene ID" value="B6264_04895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32618">
        <property type="protein sequence ID" value="OEV32618"/>
        <property type="gene ID" value="HS99_0015185"/>
    </dbReference>
    <dbReference type="OMA" id="LQQMVLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="34409" checksum="F54CC5E35AED7393" modified="2017-01-18" version="1">MALTRQATEHGHTVADDDVSKRLLESAATLSFDPMTEIDWDAPLPEEHYGLNPEWSTLYGTRLWDGMTEQQRVTLTRHEVCSIMNTGIWFEMILQQMVLRDQYLKNPANAEFQFALTEIADECRHSIMFARACQKMGVPAYRPNKVIAQAGRAFKALAKGELAYGGILVAEEVLDVMQRDWMRGENVLEIVRGTSRIHVVEESRHMKFARQEIRERMRHAGPARRRTSATGIAIGAYVIVSSMVHPGVYKAAGLDVARALAEVKENEHRKAMMRNSSRHLMAFLAEAGLLTSRSAAVYRRVHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW34</accession>
    <name>A0A1E7MW34_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553399.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000156.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3866"/>
    <dbReference type="EnsemblBacteria" id="ARF78316">
        <property type="protein sequence ID" value="ARF78316"/>
        <property type="gene ID" value="B6264_04745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32642">
        <property type="protein sequence ID" value="OEV32642"/>
        <property type="gene ID" value="HS99_0015335"/>
    </dbReference>
    <dbReference type="OMA" id="FNTGDYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="57168" checksum="DE26B1A1BD3B2F43" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG4</accession>
    <name>A0A1E7MWG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3812"/>
    <dbReference type="EnsemblBacteria" id="OEV32782">
        <property type="protein sequence ID" value="OEV32782"/>
        <property type="gene ID" value="HS99_0015060"/>
    </dbReference>
    <dbReference type="OMA" id="QINSGLC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15200" checksum="882A4CE5A0C0A27C" modified="2017-01-18" version="1">MLSTERFTALVPEAHPLADRAELSATELSAADLLTWPHQINSGLCDRLLSAFRIGGADLRIIRTADNVHAIAAHVAAGTGIGITVESALDHRPPGLRVIPLTGPSTTADQVVLTPTAPSEPAAALRDLLLHAAADATPEPATLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS1</accession>
    <name>A0A1E7MWS1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000080">
        <property type="protein sequence ID" value="OEV32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000110_gene3271"/>
    <dbReference type="EnsemblBacteria" id="OEV32880">
        <property type="protein sequence ID" value="OEV32880"/>
        <property type="gene ID" value="HS99_0039710"/>
    </dbReference>
    <dbReference type="OMA" id="AWERATH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="25273" checksum="197873DD2843387A" modified="2017-01-18" version="1">MNWDLIPRLLPWSAVDPDRHSFTWTSEEEELVTGEIRAMVPSGSPFSLSFDDFVNPVTDFLVGRYGRWACGWHWAVGEGGGGGVVQSWCCTSHSLREGPEATSAIVVASLLEWRDWLEELADRFVELAPAADANAEDRSWHVQRAATRLVTLAVDRTCAQDGWYGLCERVLTWYLSSAGLEGEEAAEIVTAAIGGRFKSWAVPGFTTVDAVAEDLAFGVTRHRPYRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX02</accession>
    <name>A0A1E7MX02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552520.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000556.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5752"/>
    <dbReference type="EnsemblBacteria" id="ARF81371">
        <property type="protein sequence ID" value="ARF81371"/>
        <property type="gene ID" value="B6264_22870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32958">
        <property type="protein sequence ID" value="OEV32958"/>
        <property type="gene ID" value="HS99_0013840"/>
    </dbReference>
    <dbReference type="OMA" id="GNPAIWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="447" mass="46418" checksum="BE2E77B35F07D565" modified="2017-01-18" version="1">MSHLSRRDLLRASGAGLLALAAGGGLAACGGADPGGGSGGDAETGTVTVWSWATAAAALRGVVPAFEKDNPGIKVDVQDIGNPAIWDKITVGLAAGGQGLGDVLHIGCDYLPGYVDKFPGGLADLSQFGATAHQDAFAKGLWPVVTGKDGHVHALPWEVNPLGFFYRQDCFDKAGIDPTTLATWDDLIAVADRFKAANPGISLIGINKAANPDPDLDFLQSLMQLQGAFYFDLQGRITLGSEPDVRALAIVRRLDAAGLVADAPGDQGWATLMKAGKLAVAPMPAWAAHYLEAKFPGQSGNWRLAKPPAVTPGGKRTALVNSTHLAVSASSPRRRAAWKFVEYALTRPASVNAMFAAGGVFPALTAAYSDPLYSAPRPYFGGQPVLKTFADLAVDGGDPTNYSGDYARALKVVGDAQTKVFLESGDPAAVLQDAAGRLAQQTGRTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX33</accession>
    <name>A0A1E7MX33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290215.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7851"/>
    <dbReference type="EnsemblBacteria" id="ARF82614">
        <property type="protein sequence ID" value="ARF82614"/>
        <property type="gene ID" value="B6264_04310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32803">
        <property type="protein sequence ID" value="OEV32803"/>
        <property type="gene ID" value="HS99_0015775"/>
    </dbReference>
    <dbReference type="OMA" id="KAYCRLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="270"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="47057" checksum="F8F013396207F47E" modified="2017-01-18" version="1">MTQGGNAPLTAARVTVEVTAPKALDVSGLLLTDAGKVRSDADFVFFNAPHGPGVSLRPASAGAPDAITVDTPAVPADISKVVITASPADQSATFAGMEPTATLRDADTDEVLVTFTPPRLGLETALIVVEVYRRNGVWKVRAVGQGYADGLAGIATDFGVTVDDSPAPTPQPAPTEAPAPASASPSAPTVQIHSTSEVAPPAPPLPATPPLPPVPPAPPAPPVDPRIALATVPSMPTMPTMPTTPPAPAAPAAAPEPAERPKVTLDKGRVSLVKGSSVSLVKNGRPFLSSVRMALGWESAARGRDIDLDASCLAFDARHQRLETAWFMKLTVFNGAIAHSGDNLVGGDGGDDEAITVHLEGLPAEVHALVFVVNSFSGQKFTELRNAYCRLVDVRTEEELVRFDLTQSEPRTGVVMCKLVRRPSGEWEMTALGEFVDGKTARAMIEPSAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXB6</accession>
    <name>A0A1E7MXB6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0014545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552408.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5610"/>
    <dbReference type="EnsemblBacteria" id="OEV33077">
        <property type="protein sequence ID" value="OEV33077"/>
        <property type="gene ID" value="HS99_0014545"/>
    </dbReference>
    <dbReference type="OMA" id="TWFALTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="32182" checksum="01B74594C5A1EBD0" modified="2017-01-18" version="1">MTGNGYAHPEALVRTEWLAHHLDDGTIRVVEVDEDTTAYERDHIPGAVGWNWATDLHSQVGRDYADREGVQHLLRAAGVEDDTTVVLYGGNNNWFAAYAYWLLRLRGFGPVKLLDGGRKKWELEGRELTHEVMDYQHTPYRLTGPERPELRAMRDEVLAKAEVFAKPGADAVLVDVRSPAEFRGELIAPPNLPQEQAQVPGHIPGAVNVPWSQAANDDGSFRSAEELRALYGGKGVGAEREVIAYCRIGERSAHTWFALTELLGYPHVKNYDGSWTEYGSLVRAPVALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE9</accession>
    <name>A0A1E7MXE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550928.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2680"/>
    <dbReference type="EnsemblBacteria" id="OEV33130">
        <property type="protein sequence ID" value="OEV33130"/>
        <property type="gene ID" value="HS99_0014875"/>
    </dbReference>
    <dbReference type="OMA" id="AAFQYWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198527" evidence="1">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="45414" checksum="317F73880318B7C0" modified="2017-01-18" version="1">MRRIWAALTTTALTAAALTGCGLGAGDSKNSDSVASAAATGEVKGKVSIQTWALKPKFTDYMQGVIDGFKKKYPGVEVDWLDQPGEGYSDKVLSQAASGTLPDVVNLPPDFAFPLAKKDVLLDVAKADPKLADEYVAGGVEAYRYNGYQGTFGYPWYLNTDVDYWNSDLLGKDGLDPKKPPTSLDELIAQARVMKEKSGGQDYLMSRKPGLGDLYDIGVKIMADDGKSFTFNTPEAAALLDRYRDAFKEGLMPNGVLTDTYAGNSKLFSAGTVAWTTGGGNYITSLATDNPTLAPKVVASPAMGTPPLYVQGLSIPKSTKNPAAAVALARWVTSPENQAAFAHLTSVFPSTKASANDPFFSRSDGTNAGNAKVIAFDSLAKAKLIQPVEVDDAMGTVVKQQFALAISGRSSSKQALDTAVAQCDKLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI2</accession>
    <name>A0A1E7MXI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33142">
        <property type="protein sequence ID" value="OEV33142"/>
        <property type="gene ID" value="HS99_0013810"/>
    </dbReference>
    <dbReference type="OMA" id="HGREYSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14037" checksum="6456EB8CEFF8D4C9" modified="2017-01-18" version="1">MLVLEEVALGLAEEEDRPVIGGALIGVSCSGLLVVGAVLFSRWLDARRPLPLPPPGPHGREYSARALEGFPMEAVRPLLLTEHAPQLGQLYSAWMLARAGRPAAWIARRLGLPLEAVQLLVDAARPDTGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY62</accession>
    <name>A0A1E7MY62_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0012330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553477.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4021"/>
    <dbReference type="EnsemblBacteria" id="ARF80474">
        <property type="protein sequence ID" value="ARF80474"/>
        <property type="gene ID" value="B6264_17555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33372">
        <property type="protein sequence ID" value="OEV33372"/>
        <property type="gene ID" value="HS99_0012330"/>
    </dbReference>
    <dbReference type="OMA" id="WMMAAKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="21451" checksum="0C399C93BA3E1FE1" modified="2017-01-18" version="1">MSKQHVGDLADVRDREELAALMAAGARPKWVMFWGHTVRKGGAVRHECLSQWWPGRFTVDGVTYASAEHWMMAGKARMFGDEAVEQRVLEARTPAEAKKLGRLVKGFDEKTWTAGRFDLVVEGNVAKFGQDEALREYLLSTGGRVLVEASPLDRIWGIGLAADDIRAERPLEWRGLNLLGFALMEARARLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB4</accession>
    <name>A0A1E7MYB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287529.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000343.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3953"/>
    <dbReference type="EnsemblBacteria" id="ARF80535">
        <property type="protein sequence ID" value="ARF80535"/>
        <property type="gene ID" value="B6264_17910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33430">
        <property type="protein sequence ID" value="OEV33430"/>
        <property type="gene ID" value="HS99_0012685"/>
    </dbReference>
    <dbReference type="OMA" id="FFSGMSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021235">
        <property type="entry name" value="DUF2637"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10935">
        <property type="entry name" value="DUF2637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41999" checksum="FA086DFB66FC3FA1" modified="2017-01-18" version="1">MNLTSIQLVWTVIGGAALLFVSVLLATLRFKNSKKDESADSWERSEDRRRRKEMIYGISSYTLLFCCAGVAAALSFHGLVGFGIENLGLSNGWEYLVPFGLDGAAMFCSVLAVREASHGDAALGSRLLVWVFAIASAWFNWVHAPRGLGHAGAPQFFSGMSISAAILFDRALKQTRKAALREQGLVPRPLPQIRIVRWLRAPRETYAAWSLMLLENVRSLDEAVEEVREERQAKMDAKVRARSADRRERAELKAISRQGGMLARARGGRQVPALTAAGDGPSATEPALAAGSDRATPIGQDPFAPMTARSSSASTSPLEPTALDAGRPRAAVGSSYSFSSSASGSTSGSTSGSASSSHRSTIDLTVDDDTLSMPKLDSLERKLRAIEQQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB7</accession>
    <name>A0A1E7MYB7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287537.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3957"/>
    <dbReference type="EnsemblBacteria" id="ARF80531">
        <property type="protein sequence ID" value="ARF80531"/>
        <property type="gene ID" value="B6264_17890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33426">
        <property type="protein sequence ID" value="OEV33426"/>
        <property type="gene ID" value="HS99_0012665"/>
    </dbReference>
    <dbReference type="OMA" id="VCTKELC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16781" checksum="B419EB45CEB80343" modified="2017-01-18" version="1">MAIEVGTPAPDFELRTQHGETVRLADFRGRKHVVLVFYPFAFTGVCTGELGAIQRELAGLQNDDVQVLGVSCDSQFGQRVFADREGLEFPLLADFWPHGEVARAYGVLDEEKGCPLRGTFVIDRAGTVRWSVVNGLPDARDEQEYLKVLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYF1</accession>
    <name>A0A1E7MYF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555535.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6601"/>
    <dbReference type="EnsemblBacteria" id="ARF80565">
        <property type="protein sequence ID" value="ARF80565"/>
        <property type="gene ID" value="B6264_18100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33462">
        <property type="protein sequence ID" value="OEV33462"/>
        <property type="gene ID" value="HS99_0012880"/>
    </dbReference>
    <dbReference type="OMA" id="INYAQQT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="30307" checksum="EE7A90ABB031179E" modified="2017-01-18" version="1">MKKPLIGMLATLLAAGTSALVGAAPAQAAAPAQVSAPAQASAQAATPAAKAVTVNFAGTVALSNCSGSLVRMPNSAATDPALVLSNGHCLESGMPGPGEVVLDQPSSRTFTLLNPTGGRLATLRATKVVYGAMTDTDVSIYQLNTNYASIKSKYGISPLTIADTHPTQGADIRVVSGYWKKIYSCSIDGFAYQLNEADWTFKDSVRYTSGCNVIGGTSGSPVVDTSTGRLVAVNNTINENGESCTLDNPCEVDENGGVTVHQGIGYAQETYGIPACFGPGNRLDLTLAGCTLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT4</accession>
    <name>A0A1E7MYT4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385738.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5178"/>
    <dbReference type="EnsemblBacteria" id="ARF82908">
        <property type="protein sequence ID" value="ARF82908"/>
        <property type="gene ID" value="B6264_18365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33605">
        <property type="protein sequence ID" value="OEV33605"/>
        <property type="gene ID" value="HS99_0013145"/>
    </dbReference>
    <dbReference type="OMA" id="TALFMEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="480" mass="49414" checksum="B54F4BDF8EB6B206" modified="2017-01-18" version="1">MLVLAICCLSLFIVGLDNTVVNIALPVIQKDLDAPASGLQWIIDAYTLVLASLLMLFGSVADRFGRRRVFQIGLTCFALGSLLCSLAPSLEWLVAFRALQAVGGSMLNPVAMSIITNTFTDLRERAQAIGVWGGVVGISMALGPLLGGFLVDGAGWPSIFLINVPVALFAILLTVRYVPESRAPRPRRLDPVGQLLMIVLLGCGTAAIIEGPGNGWTSPLILALAAAAVAALIAFPLWEWRVAEPLVDPRFFASAPFTGATVTAVCAFAGLGGFLFLNTLYLQDVRHYGPVEAGLWTLPMAGLMLVCAPLSGRIVGSRGPRLPLVVAGLGMAASGLLLTRLTADSPAALLLVAYALFGFGFGLVNAPITNAAVSGMPRSQAGVAAAVASTSRQVGQSLGVAVIGTVVTSAVAGPMATGFAPASHAGWWILVGLGGAVLVLGLLTTGAWATGTAARVAARLGAEPPVARSGVREAPPERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ95</accession>
    <name>A0A1E7MZ95_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0037845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289127.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3771"/>
    <dbReference type="EnsemblBacteria" id="ARF78403">
        <property type="protein sequence ID" value="ARF78403"/>
        <property type="gene ID" value="B6264_05240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33775">
        <property type="protein sequence ID" value="OEV33775"/>
        <property type="gene ID" value="HS99_0037845"/>
    </dbReference>
    <dbReference type="OMA" id="KNFQSAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43660">
        <property type="entry name" value="PTHR43660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="674" mass="74071" checksum="C9DE95996EE0DB39" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZL4</accession>
    <name>A0A1E7MZL4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282161.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6386"/>
    <dbReference type="EnsemblBacteria" id="ARF78743">
        <property type="protein sequence ID" value="ARF78743"/>
        <property type="gene ID" value="B6264_07265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33878">
        <property type="protein sequence ID" value="OEV33878"/>
        <property type="gene ID" value="HS99_0037380"/>
    </dbReference>
    <dbReference type="OMA" id="DIAMSAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="32308" checksum="11A61EED32AB3BB1" modified="2017-01-18" version="1">MPHLLHARRPAFAGAALAAAGALLLTGCGGGGGQAAASDPVKDVRAKLPKAQRSAGVLRIGMDVNYAPVEFRGPDGKPTGLDPDLAAALGRILDVRVEFVDTPFDKLIPGLQGKQFDVAMSALSDIRQRREGLDENGKQVNPGVDFVDYFIAGASIVVPKGNPKGIRTMDDLCGRTVALQQGTNQDDIVTRQTAVCARTGRQLTVHRFDEDAKALAEVSSGAAAAGLNDFPVAAYAVKTTDGGNRFEVAGTQSTSNPYGIAVRKGDTELRDTLSKAVDQLIRSGEYDKILAKWNVSAGAAQNAVVNGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZV2</accession>
    <name>A0A1E7MZV2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2176"/>
    <dbReference type="EnsemblBacteria" id="ARF77808">
        <property type="protein sequence ID" value="ARF77808"/>
        <property type="gene ID" value="B6264_01695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33955">
        <property type="protein sequence ID" value="OEV33955"/>
        <property type="gene ID" value="HS99_0010855"/>
    </dbReference>
    <dbReference type="OMA" id="NAPYFCQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="31630" checksum="135008C265F95001" modified="2017-01-18" version="1">MSQIVRAALVQTRWTGDQESMIALHERYAREAAAQGAGIIGFQEVFNSPYFCQVQEPEHYRWAEAVPDGPTVRRMQDLARELGLVIVVPVYEEEQTGVYYNTAAVIDADGSYLGKYRKHHIPQVKGFWEKYYFKPGNLGWPVFDTAVGKVGVYICYDRHFPEGWRALGLAGAQIVYNPSATSRGLSAYLWQLEQPAAAVANEYFVAAINRVGTEEYGDNDFYGTSYFVDPRGQFVGDVASGKEEELVVRDLDLGLIEQVRQQWAFYRDRRPDAYGPLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZX0</accession>
    <name>A0A1E7MZX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289092.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3788"/>
    <dbReference type="EnsemblBacteria" id="ARF78387">
        <property type="protein sequence ID" value="ARF78387"/>
        <property type="gene ID" value="B6264_05150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33763">
        <property type="protein sequence ID" value="OEV33763"/>
        <property type="gene ID" value="HS99_0037755"/>
    </dbReference>
    <dbReference type="OMA" id="EDAYLWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="33059" checksum="4632F679C20F2065" modified="2017-01-18" version="1">MTAAISADGIRQRYGDVQAVDGVSLTVEAGEFYGILGPNGAGKTTTMEILEGVREPDEGRVELLGMAPWPRNPKLLPRIGVQFQASAFFRKLTARETIRTFASFYGVGPKRADAMLERVGLADKAETLTEQMSGGQAQRLSIACALAHDPELVFLDEPTTGLDPQARRNLWDLLRDINDEGRTVVLTTHYLDEAEVLCDRVSIMDHGRILHTGAPAALIREIDDTVRISVASGQLPVERARELLAAAGADVATLEDDTVSLSVSTRLPAPVLSVLAEQNALRGLEVRGATLEDVFLQLTGREFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N009</accession>
    <name>A0A1E7N009_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388019.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2274"/>
    <dbReference type="EnsemblBacteria" id="ARF77885">
        <property type="protein sequence ID" value="ARF77885"/>
        <property type="gene ID" value="B6264_02165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34028">
        <property type="protein sequence ID" value="OEV34028"/>
        <property type="gene ID" value="HS99_0011315"/>
    </dbReference>
    <dbReference type="OMA" id="GQANIAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="19570" checksum="7FA25C06D7558983" modified="2017-01-18" version="1">MRELELSDGVVTLSPLRPEDAAAHLAGEDDELVRWLSGGPSTPEGVAAYFRQCREQWEADGPLRAFGIRADEEGGNGVLAGTIDLRFGHADLAPGQVNVAYGLYPPWRGRGLATRAVLLASGYGARVGAREAVIRVEPENAASAAVARRAGFRPAGRARDGHGTLHDWYLRGLDLFRPEAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N013</accession>
    <name>A0A1E7N013_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366474.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2276"/>
    <dbReference type="EnsemblBacteria" id="ARF77887">
        <property type="protein sequence ID" value="ARF77887"/>
        <property type="gene ID" value="B6264_02175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34030">
        <property type="protein sequence ID" value="OEV34030"/>
        <property type="gene ID" value="HS99_0011325"/>
    </dbReference>
    <dbReference type="OMA" id="VRQYWQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="31886" checksum="AF5338892F2FDC1A" modified="2017-01-18" version="1">MSTNANGDADLWVGLGLAEAASTARIGPAPVADILAGGRRIRRRRRTVVGALALASVVVLAGGAVSELRPGPAVSHPLVPAGPGHGSGTGGPPTAAAAPVSPTPTTAAPPARDPFTPVRVVVGEGTTPEGKQWKLWRAVWPTAPRERAYEQALALWQERSPYDSAVSKPTKEFVDRYYDPDSDVVNTYFTVDGVRLSHDAAGTSPAPGKLGPRDGTYIGGGLLGARGKGDTVAPGEIVGLSLGPDIARVKVTWTDGTVTEPPLVTVADSPLREAVVARPEGRTARLWEYFDRNGNKVPDSGAQFLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N059</accession>
    <name>A0A1E7N059_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000766.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2332"/>
    <dbReference type="EnsemblBacteria" id="ARF77936">
        <property type="protein sequence ID" value="ARF77936"/>
        <property type="gene ID" value="B6264_02460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34078">
        <property type="protein sequence ID" value="OEV34078"/>
        <property type="gene ID" value="HS99_0011605"/>
    </dbReference>
    <dbReference type="OMA" id="RAGRTQW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="36147" checksum="AC1802BB843ABFC3" modified="2017-01-18" version="1">MLDELDRALVHALRVDGRAPFSRIASVLDVSPQTVARRYRRLRSEAGLRVVGLADPHRAGRVQWLLRLTAGPHTAQGLAQALVRRGDTAWVKLTSGGTEITAIVETDPGPDGHTLLLRDIPRTAAVTAVSAHCLLHTYRGGPTAWPVSTEALTEQQQAALRPGDLGAPNSPSTLGGPNAPGSPGAPGGRPPGLDASDLALLGALHVDGRTPLGELAAATGRTPATAARRLGELRADGTVFLDVELDPRLLGAGMQALLWLSITPAHVDRVGRALATHRELAFVAATTGPSNLAALALCTDPADLHRYLTRRLGEVAGITALESAPVLRTLKAAGPVPTAGRADRSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N062</accession>
    <name>A0A1E7N062_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdhD</name>
        <name evidence="2" type="ORF">HS99_0011655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289964.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2342"/>
    <dbReference type="EnsemblBacteria" id="ARF77946">
        <property type="protein sequence ID" value="ARF77946"/>
        <property type="gene ID" value="B6264_02510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34087">
        <property type="protein sequence ID" value="OEV34087"/>
        <property type="gene ID" value="HS99_0011655"/>
    </dbReference>
    <dbReference type="OMA" id="RYCAGAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="29744" checksum="4A4A8CF3266BE57E" modified="2017-01-18" version="1">MGRVTVPRRILRLRQGTPSHRPDTLAAEEPMEIRVGGRPLTVTMRTPGSDFDLAAGFLVSEGVLHAADHLAGIRYCAGATADGGNTYNVVDVVLAAGVPAPDASLERNFYTTSSCGLCGKASLDAVRTTAPWSVAEDGLRVTPELLSALPDRLRAAQKVFDSTGGLHAAGLFDAGGRLLCLREDVGRHNAVDKVVGHALREGLLPARGTVLMVSGRASFELVQKAVMAGIPMLAAVSAPSSLAADLAEESGLTLVGFLRGDSMNVYTRTDRIDTGPEDASRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L6</accession>
    <name>A0A1E7N0L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033347090.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000324.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1958"/>
    <dbReference type="EnsemblBacteria" id="ARF82784">
        <property type="protein sequence ID" value="ARF82784"/>
        <property type="gene ID" value="B6264_12315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34216">
        <property type="protein sequence ID" value="OEV34216"/>
        <property type="gene ID" value="HS99_0037165"/>
    </dbReference>
    <dbReference type="OMA" id="LEWRPIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="510" mass="53668" checksum="3EE8C76A624744B7" modified="2017-01-18" version="1">MTRTVPDVQQRTSEENGMTTAGADRRRWIALAIVMVASFMDLVDVTIVNIAIPSIQQDTGASFSAIQWVTGGYALAFAIGLITGGRLGDIHGRKRLFLIGIGGFTLASALCGLASGPEMLVAMRILQGGTAALMVPQVLSIIHATFPAEERGKVFGMFGAVVGLGAVSGPMIGALLTEWNLLGLEWRPIFLINLPVGIAGLLLGRRFIDESRAEHALKLDLVGVALASLGLLMLIYPLTHGREAGWPLWGYLSMAGSLPVFVLFVVYEKAKTRRDGSPLVELSLFRVKSFAAGICVQLAFGVALGIFFLVWTLYMQVGLGWSPLKAGATGIPFSLAVSTAAGLSVQKLVPRFGRKVLQAGALIMAVGVLVYIGEAHRYGTGIAPWQMALPLVVMGLGMGLIVAPITDAILSEVPRRHAGSASGLINTVQQVGNALGLGLVSVAFFGAMDDVVAPDALGTAFGGAFVHAMWWVAGVLLAVFLLMFALPRKRGVAVEAGAPDGAEQRESVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N9</accession>
    <name>A0A1E7N0N9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285672.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6070"/>
    <dbReference type="EnsemblBacteria" id="ARF78160">
        <property type="protein sequence ID" value="ARF78160"/>
        <property type="gene ID" value="B6264_03835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34244">
        <property type="protein sequence ID" value="OEV34244"/>
        <property type="gene ID" value="HS99_0036935"/>
    </dbReference>
    <dbReference type="OMA" id="GNCNHRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="35843" checksum="843744F53E878C4C" modified="2017-01-18" version="1">MRATVIHGPNDIRIEEVPDPVIQHPTDVVLRVVNACICGSDLWAYRGVAERVAGQRIGHEFLGVVEEVGAEVRGFTKGDLVVAPFVWSDGVCEFCLEGLQTSCPHGGFWGQVGSDGGQGEAVRVPFADGTLVKLPKEAAGDEKLLPGLLALSDVMSTGHHAAVSARVRPGATVAVVGDGAVGLCGVLAANRLGAGRIIALGRHPARTELARRFGATDVVAERGEAAIEAVKELTGGLGAHAVLEAVGTEESMRTAISITRDGGAVGYVGVPHGGSAGVDIGQMFGRNVSLNGGVAPARAYIPELLPDVLSGAIEPGLVFDRTVGLDGVPDGYRAMDDRSALKVRIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N128</accession>
    <name>A0A1E7N128_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553536.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3924"/>
    <dbReference type="EnsemblBacteria" id="OEV34371">
        <property type="protein sequence ID" value="OEV34371"/>
        <property type="gene ID" value="HS99_0036230"/>
    </dbReference>
    <dbReference type="OMA" id="FAHWQTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="40976" checksum="E59E2C4FFD1EA697" modified="2017-01-18" version="1">MPSPDEHPEEYLYRAASERPYFSADTESYLARTALRELRKKLPLRVLSEEDFAYWQTYGYVVVEQAIPADAARRLLDFTWEFQGLSPDRPQDWYRAREYRDELDRHLHIYGFVEAYHHQLIWDSRQAQRVYDAFVDVWDCEELWVTLDRLNLNPPNVRNRDRALIEPTDKGFDIELHWDVDTTRGMLPQRVQGIIALNDTAPDHGGFQCNPELFRRFNEWQAAQPADRDPIRPAVDRAEFPVVRPELKAGDLLIWNGLLAHGVAPNTSEDGVRSVQYLSMMPALEEAEPLRRSRVESWRTLATPDWNRTLVGDADRPEALRYGRAELTELGEKLLGLRSWTGQGFEQPAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B0</accession>
    <name>A0A1E7N1B0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0035850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene373"/>
    <dbReference type="EnsemblBacteria" id="ARF78924">
        <property type="protein sequence ID" value="ARF78924"/>
        <property type="gene ID" value="B6264_08345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34477">
        <property type="protein sequence ID" value="OEV34477"/>
        <property type="gene ID" value="HS99_0035850"/>
    </dbReference>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="41939" checksum="33CCFE168FA603CC" modified="2017-01-18" version="1">MHNWPITLDDVRGAQKMLAGVARVTPMEGSRHLSGLIGAPVHLKCENLQRTGSFKLRGAYVRIAGLSPVQRAGGVVAASAGNHAQGVALAASLLGVRSTVFMPVAAPLPKVAATREYGAEVRLHGTTVDEALQAAQRYSEATGAVFIHPFDHWDVVTGQATVGLEILEQCPEVRTILVGVGGGGLLAGIAAAVKPLRPDVRVVGVQAAAAAAYPPSLAAGRPVTLEHFATMADGIMVGRPGDIPFEVVNTLADGIRTVSEDALARALLLGLERLKLVVEPAGAAPIAALLEQPDSFEGPVVAVLSGGNIDPQLMQRVLRHGLAAAGRYLSLRVRLADKPGSLADLLGVLTRVDANVLDVAHVRTDPRLGLTEVEVDLHLETKGPEHCALVVGELRDAGYVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G9</accession>
    <name>A0A1E7N1G9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289549.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6118"/>
    <dbReference type="EnsemblBacteria" id="ARF79323">
        <property type="protein sequence ID" value="ARF79323"/>
        <property type="gene ID" value="B6264_10685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34537">
        <property type="protein sequence ID" value="OEV34537"/>
        <property type="gene ID" value="HS99_0035165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7722" checksum="81335B297A548A68" modified="2017-01-18" version="1">MTDRTPLFRTDRTDLTPEEIATLTVLLLQRHRTQAATTGHHPAPRRVRWHDVSLRPPTPTTSWQIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J9</accession>
    <name>A0A1E7N1J9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0036480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6427"/>
    <dbReference type="EnsemblBacteria" id="ARF78707">
        <property type="protein sequence ID" value="ARF78707"/>
        <property type="gene ID" value="B6264_07055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34343">
        <property type="protein sequence ID" value="OEV34343"/>
        <property type="gene ID" value="HS99_0036480"/>
    </dbReference>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="38100" checksum="3DE944834D596A98" modified="2017-01-18" version="1">MNAVAENVVRGAHTHQWRGLIEEYRDRLPVTATTPVVTLLEGGTPLVPAQVLSERTGCEVYLKVEGANPTGSFKDRGMTMAISKAKEAGAQAVICASTGNTSASAAAYAVRAGMVSAVLVPQGKIALGKMGQALVHGAKILQVDGNFDDCLTLARELSEKYPVALVNSVNPVRIEGQKTAAFEIVDMLGDAPDIHVLPVGNAGNITAYWKGYREYATDGMAARTPRMWGFQASGSAPIVDGAPVLKPQTIATAIRIGNPASWDFALAARDESGGLIDKVTDRQILAAYRLLAAQEGVFVEPASAASVAGLLAKAEAGLVDPGQRIVCTVTGNGLKDPDWAVAGAPQPQVVPIDPEAAARRLGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1X1</accession>
    <name>A0A1E7N1X1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555958.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4663"/>
    <dbReference type="EnsemblBacteria" id="ARF81936">
        <property type="protein sequence ID" value="ARF81936"/>
        <property type="gene ID" value="B6264_26350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34700">
        <property type="protein sequence ID" value="OEV34700"/>
        <property type="gene ID" value="HS99_0009430"/>
    </dbReference>
    <dbReference type="OMA" id="FGSIGSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="29601" checksum="0B83D132D9D09BCB" modified="2017-01-18" version="1">MTRTWLITGASRGFGRCLTEAVLESGDQVLATARQPEQLADLISRYGARVRTTALDVTDAAAARAAVDGAVAAFGRLDVVVNNAGYANSGPIEEMTDQDFREQFETNFFGVVNVTRAALPVLREQRSGVFVQFSSLGGRVGGTPGMGAYQSAKFAVEGFSEVLAGEVAPFGVKVVIVEPGAFRTDWQGSSMELHPVVGPDYEETVGAMNRYRQENNGTQPGDPARAARVIIDVIGHDDPPRRLLLGAQAVTAALAAGAARAEETRKWAGASAAADFPAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z7</accession>
    <name>A0A1E7N1Z7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4669"/>
    <dbReference type="EnsemblBacteria" id="ARF81941">
        <property type="protein sequence ID" value="ARF81941"/>
        <property type="gene ID" value="B6264_26375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34695">
        <property type="protein sequence ID" value="OEV34695"/>
        <property type="gene ID" value="HS99_0009405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19839" checksum="9B23B1446FE934DE" modified="2017-01-18" version="1">MEQKVTVLEARRAMRYLVRRHGTPAPGPRPDLYVMPSARQWAAIPSWEWHKAGVDPKRAPTILRAVRLAPRLEEASTMAGAQAFERLMTVPGIGIWTAAETLQRDNGDPDAVSVGDYHLANHIGHFFTGRARSTDEQMLELLAPYAGQRHRVCTLAFLAGASAPRFGPRLSPNDHRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N222</accession>
    <name>A0A1E7N222_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279016.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2575"/>
    <dbReference type="EnsemblBacteria" id="OEV34513">
        <property type="protein sequence ID" value="OEV34513"/>
        <property type="gene ID" value="HS99_0035540"/>
    </dbReference>
    <dbReference type="OMA" id="MNTWEDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23408" checksum="5A6DBC87311606DD" modified="2017-01-18" version="1">MVDFANVHAAPSPDLLTPDNAMMLFVDHQPQMFFGTGSGDRTAIINATVGLAKAAKIFGVPTVLSTVAAESFSGPILPQLKAVFPGQEIIDRTSMNAWEDEALVEAVKATGRKKIILSGLWTEVCLVLPALSALDQGYEVYVVADASGGVSPLAHEHALQRMTAAGAVPVTWIQVLLELQRDWARTETYVPVTELVKEHGGAYGLGLVYAQSMINPHAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N271</accession>
    <name>A0A1E7N271_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81863">
        <property type="protein sequence ID" value="ARF81863"/>
        <property type="gene ID" value="B6264_25890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34775">
        <property type="protein sequence ID" value="OEV34775"/>
        <property type="gene ID" value="HS99_0009860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="725" mass="80176" checksum="880604F5A4050018" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B9</accession>
    <name>A0A1E7N2B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557746.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7611"/>
    <dbReference type="EnsemblBacteria" id="ARF81790">
        <property type="protein sequence ID" value="ARF81790"/>
        <property type="gene ID" value="B6264_25420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34848">
        <property type="protein sequence ID" value="OEV34848"/>
        <property type="gene ID" value="HS99_0010300"/>
    </dbReference>
    <dbReference type="OMA" id="PAIWTIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="48871" checksum="E640B19BFBA1F532" modified="2017-01-18" version="1">MQPYELSLAAAADAIRARRLSPVELVDSVLDRIEEVEPHLGAYVTVAAERARRAAGEAEHEAAHGRYRGPLHGIPMALKDLIDVGGMATTASSRVRADHRATADSTVAARLSAAGAILLGKTHTHEFAFGLTTPQTRNAWDRTRVAGGSSGGSAVAVASGTATFALGTDTGGSIRVPAALNGVVGLKPTYGLVPRHGVTPLSWSLDHVGPLTRTVEDAALVLTALAGHDPRDPASLSVPATDYRPGVGTDLTGLRIGVPRTYYFDHVHPQVETAVRHAVGQLEALGAQLVEVDIPMTRYIQATQWGLMVPEAGAYHEGSLRTVPELYQDDVRILLEASELMSAGDYLRAQRSRTLMRAEWARMLEEVDVIAAPSVPMPAVGADEETVTWPDGTAESVSDAYVRLCAPANITGMPALTVPVGHDAGGLPIGMQLIGRPLGEPVLLRVGHAYEQTQPTRALATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D0</accession>
    <name>A0A1E7N2D0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557756.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7618"/>
    <dbReference type="EnsemblBacteria" id="ARF81797">
        <property type="protein sequence ID" value="ARF81797"/>
        <property type="gene ID" value="B6264_25455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34841">
        <property type="protein sequence ID" value="OEV34841"/>
        <property type="gene ID" value="HS99_0010265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10808" checksum="116B5F50BEA7A1B0" modified="2017-01-18" version="1">MAAVSLTGCGVFGHSWDVKLEVTGPGSADVGYSFSGDTSGKTALNQKLPWNKAQNVGFGFNDLAVKNAKPGTVCRIYVDGELKVEQNKPNAEGALSCFIQLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F0</accession>
    <name>A0A1E7N2F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557719.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000838.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81774">
        <property type="protein sequence ID" value="ARF81774"/>
        <property type="gene ID" value="B6264_25320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34864">
        <property type="protein sequence ID" value="OEV34864"/>
        <property type="gene ID" value="HS99_0010400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="27018" checksum="C823123E54F3B1A3" modified="2017-01-18" version="1">MTGETEMTELFGAVLSRHRVNTGARWQNAMWALLLAVPTGWLGLWALFSADDGRSGGGRAIGLVIGLSLGALFVAVTQAWRAVRGGPGEYFEVHERGLVHGSRRGVRGWEWSQVVSITIPGTPRIHGLARRLGNDYRCRLVLDGGTRLHIDGHTPGASGLGRAVLAHSPHARRLQGDEWQDRAGGWFLAGAVVFLAVGVSLVSYLVSHADEDAQNVSEGVTMAVGLGLPVCAVGAITCIVLYVRHRMYRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y1</accession>
    <name>A0A1E7N2Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0034530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552903.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4730"/>
    <dbReference type="EnsemblBacteria" id="OEV35051">
        <property type="protein sequence ID" value="OEV35051"/>
        <property type="gene ID" value="HS99_0034530"/>
    </dbReference>
    <dbReference type="OMA" id="GCLFTTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21465" checksum="6206A7257D69AE46" modified="2017-01-18" version="1">MPRRSAAEARDTRARILDRAVVIAARDGLEGVTIGRLADDLEMSKAGVYGHFGSKEALQLATFDAAVEQFRQLVPARVPRTATGIERLRHLCDAWIDYLEHGGIAEGGCFLTAAATEFDGRPGPVRDAVAQAAGRWLAYLEHLAAAAVETGDLPPDTDPAQIAFELNGIAMSANQAIQLQRDDAAPQRARRAMHRAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N303</accession>
    <name>A0A1E7N303_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0034590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737924.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4742"/>
    <dbReference type="EnsemblBacteria" id="OEV35060">
        <property type="protein sequence ID" value="OEV35060"/>
        <property type="gene ID" value="HS99_0034590"/>
    </dbReference>
    <dbReference type="OMA" id="VIHAACT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="320"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="712" mass="74202" checksum="F961345A5AAED60D" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N334</accession>
    <name>A0A1E7N334_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0034030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene418"/>
    <dbReference type="EnsemblBacteria" id="OEV35085">
        <property type="protein sequence ID" value="OEV35085"/>
        <property type="gene ID" value="HS99_0034030"/>
    </dbReference>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="36417" checksum="3AE9B764E9026FE0" modified="2017-01-18" version="1">MTTQYPHHLPSALEVAPEAPDRNLALELVRVTEAAAMAAGRWVGRGDKNGADGAAVKAMRTLVSTVSMNGVVVIGEGEKDEAPMLYNGERVGDGTGAECDVAVDPVDGTTLTAKGMNNAVAVLAVADRGTMFDPSAVFYMDKLVAGPEAAEFVDITAPAAVNIRRVAKAKGSAVEDVTVVVLDRPRHDGLVREIREAGARIKFISDGDVAGAIMAAREGTGVDLLMGIGGTPEGIIAACAMKCMGGVIQGRLWPKDDAERQKALDAGHDLDRVLTTNDLVSGENVFFVATGITDGELLRGVHYRSETATTSSLVMRSKSGTIREINSVHKLSKLRAYSAIDFDRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N336</accession>
    <name>A0A1E7N336_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alkyl hydroperoxide reductase AhpD</fullName>
            <ecNumber evidence="1">1.11.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alkylhydroperoxidase AhpD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ahpD</name>
        <name evidence="2" type="ORF">HS99_0034110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="Rhea" id="RHEA-COMP:16355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.11.1.28"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AhpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.28" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286643.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000600.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene404"/>
    <dbReference type="EnsemblBacteria" id="ARF78899">
        <property type="protein sequence ID" value="ARF78899"/>
        <property type="gene ID" value="B6264_08200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35096">
        <property type="protein sequence ID" value="OEV35096"/>
        <property type="gene ID" value="HS99_0034110"/>
    </dbReference>
    <dbReference type="OMA" id="AIMAMNN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032843">
        <property type="term" value="F:hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01676">
        <property type="entry name" value="AhpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004674">
        <property type="entry name" value="AhpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00777">
        <property type="entry name" value="ahpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with AhpC); in linked form" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="19007" checksum="A30DE2713BA4D933" modified="2017-01-18" version="1">MALDDLKAALPDYAKDLKLNLGSVIGNSDLPAQQLWGTVLSCAMATRSPGLLRELEPEAKANLSPEAYTAAKGAAAIMGMNNVYYRTLHLLSDKEYSTMRAGLRMNIIGTPGVEKVDFELWCFAVSAINGCGQCLDSHEAVLRKAGVEREVIQASLKIAAVLQAVAGVLDSEAALAAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N358</accession>
    <name>A0A1E7N358_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286602.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene377"/>
    <dbReference type="EnsemblBacteria" id="ARF78920">
        <property type="protein sequence ID" value="ARF78920"/>
        <property type="gene ID" value="B6264_08325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35117">
        <property type="protein sequence ID" value="OEV35117"/>
        <property type="gene ID" value="HS99_0034235"/>
    </dbReference>
    <dbReference type="OMA" id="YCTVRSQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14155" checksum="7AED355AC70DB2DD" modified="2017-01-18" version="1">MTAQSTATQLPEGRYGRRGDGESDRRLKVVGAVCGVLGLGLIAWLGGSYLLRESKINGSVPTFQVLSDSEVQLHLSVSKSDGTAGTCTVRSQSDDHAVVGVADFPVPAAGSSYDATVTLRTTARGTTAELLGCTPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I5</accession>
    <name>A0A1E7N3I5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0032855</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282716.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5264"/>
    <dbReference type="EnsemblBacteria" id="ARF80682">
        <property type="protein sequence ID" value="ARF80682"/>
        <property type="gene ID" value="B6264_18795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35258">
        <property type="protein sequence ID" value="OEV35258"/>
        <property type="gene ID" value="HS99_0032855"/>
    </dbReference>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="48649" checksum="E85B2A5B1CBA2A2D" modified="2017-01-18" version="1">MANDASTVFDVVILGGGSGGYAAALRAAQLGLSVALVEKGELGGTCLHRGCIPTKALLHAAEIADETKEAAEFGVLATFQGIDINGVHKYKDDVIAGLYKGLQGLVASRKVTFVQGEGKLSSQTSVDVNGQRIEGRHIVLATGSVPRSIPGLEIDGNRVISSDHALKLDRIPKSAVILGGGVIGVEFASVWKSFGVDVTIVEALPHLVPLEDENSSKLLERAFRKRGIKFELKARFSGVEYTEAGVRVSTENGKQIDADLLLVAIGRGPVSAGLGYEENGVAMDRGYVLVDEYMRTNVPTISAVGDLAPTLQLAHVGFAEGILVAERLAGLKPVPIDYDGVPRVTYSNPEVASVGISEAKAVELYGKEKVVTLKYNLAGNGKSKILKTAGEIKLVQVKDGAVVGVHMVGARMGEQVGEAQLIYNWEALPAEVAQLIHAHPTQSEALGEAHLALAGKPLHAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L6</accession>
    <name>A0A1E7N3L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-phosphate glycerol 3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550006.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5314"/>
    <dbReference type="EnsemblBacteria" id="ARF80724">
        <property type="protein sequence ID" value="ARF80724"/>
        <property type="gene ID" value="B6264_19045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35299">
        <property type="protein sequence ID" value="OEV35299"/>
        <property type="gene ID" value="HS99_0033105"/>
    </dbReference>
    <dbReference type="OMA" id="RPWVEGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="30654" checksum="01818FFA25A8C191" modified="2017-01-18" version="1">MFYRLMKMIVAPLLRIFFRPWIEGEENIPTEGAAIIASNHLSFSDSFFFPALIKRRVTFIAKAEYFNTPGLKGRLTAAFFKGVGQLPVDRSGVRGAGEAAIRSAIAVLDRGELFGVYPEGTRSPDGKLYRGKVGGLARVALATGAPVIPVAMIDTEKVQPPGQVIPNFGIRPGIRIGRPLDFSRYHGMENDRFILRSVTDEVMYEIMRLSGQEYVDIYATAAKRQISDEKKKAEAERRAAAKAEKAEAAEAEKAAEAEKAAEAGKAEQQDQQEQKGTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4E2</accession>
    <name>A0A1E7N4E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0031725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052743547.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000802.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5549"/>
    <dbReference type="EnsemblBacteria" id="OEV35542">
        <property type="protein sequence ID" value="OEV35542"/>
        <property type="gene ID" value="HS99_0031725"/>
    </dbReference>
    <dbReference type="OMA" id="MLRGPYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008620">
        <property type="entry name" value="FixH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05751">
        <property type="entry name" value="FixH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198756" evidence="10">
        <location>
            <begin position="19"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="12">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="649" mass="66336" checksum="B36475D634E93D60" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N550</accession>
    <name>A0A1E7N550_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286071.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000957.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3372"/>
    <dbReference type="EnsemblBacteria" id="ARF81036">
        <property type="protein sequence ID" value="ARF81036"/>
        <property type="gene ID" value="B6264_20920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35826">
        <property type="protein sequence ID" value="OEV35826"/>
        <property type="gene ID" value="HS99_0008140"/>
    </dbReference>
    <dbReference type="OMA" id="NYGDHSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="443" mass="48220" checksum="8DEC10857CE75CDD" modified="2017-01-18" version="1">MSERSESAAPKVTAESEVAEICRDLIRIDTSNYGDGSGPGERRAAEYVAEQLAEFGVEPQIFESAKGRASTVIRIEGEDRSRPGLLIHGHTDVVPANAADWTYDPFGGEIADGCVWGRGAVDMKDMDAMTLAVVRDRLRTGRKPPRDLVLAFLADEEAGGTYGARFLVDKHPELFEGVTEGIGEVGGFSFTVNDQVRLYLVETAEKGMHWMRLTVEGRAGHGSMENDDNAITELCEAVARLGRHKFPLRITKTVRAFLDELSDALGVELDPENMDETLRVLGGIAKMIGTTLRNTAQPTMLGAGYKVNVIPGQATAHVDGRFLPGYEEEFLAELDSVLGPRVKRESLHSDRAIETGFDGSLVEAMQTALRAEDPIARAVPYCLSGGTDAKSFQDLGIRCFGFAPLQLPPELDFAGMFHGVDERVPVDGLKFGVRVLDRFIDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P3</accession>
    <name>A0A1E7N5P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281568.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene822"/>
    <dbReference type="EnsemblBacteria" id="ARF82954">
        <property type="protein sequence ID" value="ARF82954"/>
        <property type="gene ID" value="B6264_20300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35964">
        <property type="protein sequence ID" value="OEV35964"/>
        <property type="gene ID" value="HS99_0007530"/>
    </dbReference>
    <dbReference type="OMA" id="TEDLLCQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="14177" checksum="8BED77B1C9288CBE" modified="2017-01-18" version="1">MSRRSYDQYCAVARALDAVGERWSLLIVRELLGGPRRYTDLHADLPGVSTDILAARLKQLEGEGLVERRRLERPANATVYELTERGRELRPVIEALGAWGLSALGEQRPTDAVREHWFTAPKAAVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5W5</accession>
    <name>A0A1E7N5W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835532.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80041">
        <property type="protein sequence ID" value="ARF80041"/>
        <property type="gene ID" value="B6264_14965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36096">
        <property type="protein sequence ID" value="OEV36096"/>
        <property type="gene ID" value="HS99_0030985"/>
    </dbReference>
    <dbReference type="OMA" id="ILHTIAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="456" mass="45819" checksum="CF9D94D6242EAFB1" modified="2017-01-18" version="1">MRNQPRRILAAAATAALVSGVALASGPAALAAPTPAGTTQGTQATSPVTVTTSAFPAAVKPGTSVEFTSTLKNTADHQMDVTTAFSLSTVRGSGPRPSQLKLEYQRPGSTQWQDARATTTDAGGFWELDEFATQLHLAAGAEATYRLRLSFTADAAPGPASAGLLAMVSDPTLPPEQRITQAWGTTPFFTVESGTPTPVPTPAATADVRLGGVPAVFTAGAAAKPLKLVLTNNSGKDLRIVPVLVFQGQTVLPSETVRFEFQGPNGNWVEGTPGGDSDHPTWQYQALRTGDKDSEVITLPKGGTRTINLRLAFTKDAPALAESLVAVVGTQPGAGESVAEASSPKADFNIVGPAAPTGTPAPTTPAADTAPAAPDPSTAPVAVPAAQVTTGAPSPAAETAQSAAGAPAAVTATRLASTGGGSSSAPMAITGATAIALGIGTLLVARRRNGAQGARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X4</accession>
    <name>A0A1E7N5X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280969.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4967"/>
    <dbReference type="EnsemblBacteria" id="ARF80035">
        <property type="protein sequence ID" value="ARF80035"/>
        <property type="gene ID" value="B6264_14935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36091">
        <property type="protein sequence ID" value="OEV36091"/>
        <property type="gene ID" value="HS99_0030955"/>
    </dbReference>
    <dbReference type="OMA" id="IVMMMSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20128" checksum="B22B5167F5D7CB07" modified="2017-01-18" version="1">MSVDPAVFARLREIADQLPQVPGIGKVEIAEGKIVMMMSPVMRHELAVLLIARQLNAQLPTTHPSHIAYHGADLVDVGLGQLRNPDLMVFPEAVLASEQSAVLPHQVLLAVEIVSKSNPENDYLNKVRDYSAMGIPYYLLVDPRTGTGIVHSEPGYESREKFVFGDKIAVGPWTIDTSGLLTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N611</accession>
    <name>A0A1E7N611_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allantoate amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0031175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5011"/>
    <dbReference type="EnsemblBacteria" id="OEV36131">
        <property type="protein sequence ID" value="OEV36131"/>
        <property type="gene ID" value="HS99_0031175"/>
    </dbReference>
    <dbReference type="OMA" id="IWPHGRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42528" checksum="196E6F2BDB7A4EB1" modified="2017-01-18" version="1">MTFQEMWAELLPVGRSAASGGYRRFAWNSADAECRAWFEQQARGRGLTYELDRNGNQWAWLGDPHGEGAVVTGSHLDSVPDGGAFDGPLGVVSSFAALDELRARGAEFDKPLAIVNFGDEEGARFGVACIGSRLTAGVLSRDAAYELRDAGGVRLPDAMEKAGYDPTAIGADEERLSRIGAFVELHVEQGRHLAEGQPVGVAGAIWPHGRWRFDFHGEANHAGTTRIEDRRDPMLTYANTVLAARKKAKLAGALATFGKVAVEPNGTNAIASLVRGWLDSRAADERTLTELVAEIERAAAERGERDGVRVELTRESYTPVVDFDGPLRDRLAKLLDAPVLPTGAGHDAGILASAIPTAMLFVRNPTGVSHSPAEHAETADCLAGVTALADVLEDLACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N623</accession>
    <name>A0A1E7N623_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386474.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5000"/>
    <dbReference type="EnsemblBacteria" id="ARF82842">
        <property type="protein sequence ID" value="ARF82842"/>
        <property type="gene ID" value="B6264_15095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36156">
        <property type="protein sequence ID" value="OEV36156"/>
        <property type="gene ID" value="HS99_0031115"/>
    </dbReference>
    <dbReference type="OMA" id="YCHQRVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="605" mass="63666" checksum="33096F813D8380D7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6A5</accession>
    <name>A0A1E7N6A5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551573.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8034"/>
    <dbReference type="EnsemblBacteria" id="ARF79849">
        <property type="protein sequence ID" value="ARF79849"/>
        <property type="gene ID" value="B6264_13885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36237">
        <property type="protein sequence ID" value="OEV36237"/>
        <property type="gene ID" value="HS99_0030830"/>
    </dbReference>
    <dbReference type="OMA" id="PKWRFQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="806" mass="85406" checksum="90E92535A3110A22" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6B9</accession>
    <name>A0A1E7N6B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551585.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8048"/>
    <dbReference type="EnsemblBacteria" id="ARF79837">
        <property type="protein sequence ID" value="ARF79837"/>
        <property type="gene ID" value="B6264_13815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36225">
        <property type="protein sequence ID" value="OEV36225"/>
        <property type="gene ID" value="HS99_0030760"/>
    </dbReference>
    <dbReference type="OMA" id="VHGWFAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="27618" checksum="DBFAE9B5AB3D337E" modified="2017-01-18" version="1">MTIPHRVTGTGDHHVLVLHDWFGTSAGWGPFLDYLDGRAFSYAFLDYRGYGERKDVTGEYTLAEIAADALALADQLDWDRFSLVGHSMGGKAAQQVLAEAPLRVRKLVGLAPVPAGAYPLDEAGEALFYGAAGDREKRYAILDLVTGQRAGRVWLDRMVDQSLRLSNAEAFDGYVRDWTTADLERRINGNPVPVKVIVGEHDLALTADVMRGTWLEHYPNAELEELGGSGHYPMYEAPVALASSLESFLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6D2</accession>
    <name>A0A1E7N6D2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8070"/>
    <dbReference type="EnsemblBacteria" id="OEV36251">
        <property type="protein sequence ID" value="OEV36251"/>
        <property type="gene ID" value="HS99_0030650"/>
    </dbReference>
    <dbReference type="OMA" id="FHGHEVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="1">
        <location>
            <begin position="422"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="55718" checksum="5920F2866C9AEFE6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E9</accession>
    <name>A0A1E7N6E9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal protein PDZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551571.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8032"/>
    <dbReference type="EnsemblBacteria" id="ARF82825">
        <property type="protein sequence ID" value="ARF82825"/>
        <property type="gene ID" value="B6264_13895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36255">
        <property type="protein sequence ID" value="OEV36255"/>
        <property type="gene ID" value="HS99_0030840"/>
    </dbReference>
    <dbReference type="OMA" id="SSYPEQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="36114" checksum="47D7960B0EA2ADCD" modified="2017-01-18" version="1">MLAPGAVAVVTALALALAGCNSSTSSSSAAASPTAGSPSGTTKQASSAPGTQPGSANQLQDAYQKVIGDVLPSVVQITTGDSLGSGIVYDDKGDIVTNAHVVGSATTFTVTLANTTKSLDATLVASYPDSDLAVIKLGSPPSGLRPATFGDSGKVQLGQITLAMGSPLGLSGSVTQGIVSATGRTVSEPRNAGSPGATIGNMVQTSAAINPGNSGGALVNLDSQVIGINTLAATEPQTNGAAAPGIGFAIPASTITNIADQLIKQGKVTNSGRAALGITARTSFDQQFQPAGAVIVAVSQGGPAASAGLQPGDVITKIGDTPVDSLNALTTALASLTPGSKVTVTYTRDGNSRTADVTLGTLESSSQGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F3</accession>
    <name>A0A1E7N6F3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0030220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2634"/>
    <dbReference type="EnsemblBacteria" id="OEV36286">
        <property type="protein sequence ID" value="OEV36286"/>
        <property type="gene ID" value="HS99_0030220"/>
    </dbReference>
    <dbReference type="OMA" id="YEMANND"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="729"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="804" mass="86967" checksum="BAC937A5B867FF8F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F4</accession>
    <name>A0A1E7N6F4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+)--protein-arginine ADP-ribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:19149"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:15087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:142554"/>
            <dbReference type="EC" id="2.4.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Arg-specific ADP-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.31" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283558.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000315.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2650"/>
    <dbReference type="EnsemblBacteria" id="OEV36271">
        <property type="protein sequence ID" value="OEV36271"/>
        <property type="gene ID" value="HS99_0030140"/>
    </dbReference>
    <dbReference type="OMA" id="FGQNPYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106274">
        <property type="term" value="F:NAD+-protein-arginine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006471">
        <property type="term" value="P:protein ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000768">
        <property type="entry name" value="ART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01129">
        <property type="entry name" value="ART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="541" mass="59180" checksum="AE4567EE89E51F2E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L2</accession>
    <name>A0A1E7N6L2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GHMP_kinases_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2645"/>
    <dbReference type="EnsemblBacteria" id="OEV36315">
        <property type="protein sequence ID" value="OEV36315"/>
        <property type="gene ID" value="HS99_0030165"/>
    </dbReference>
    <dbReference type="OMA" id="DWYSTVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012363">
        <property type="entry name" value="PduX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF1">
        <property type="entry name" value="PTHR43527:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033887">
        <property type="entry name" value="PduX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="32934" checksum="E7F91EE332AF7715" modified="2017-01-18" version="1">MTPPQPEPPRRPSLAAPRRGIDLRTGSARAFGTFGELLQGALPGGPEFLVTLPVDRWARARFRLDPGGPLRVFPSHKTKTRRVAEAMLASCGRPGGGVLLLDGDLPVGKGMASSSADLVATVRAVGAAVGLDTSPAAVERWLRPIEPTDGVMHPGVVAFEHREVRLRERLGGLPAATVVAVDEGGLLDTVAFNRVPKVFSPAHCAEYADLLAELAAAVRAGDLARVGAVTTRSAVLNQRLAPKRNLDAMLAIAERIGAEGVVCAHSGTLLGLLLDENDADHGPRLAAAVAACSTLPGTTTTVRALNLQDMEPAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R5</accession>
    <name>A0A1E7N6R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557577.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000543.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7186"/>
    <dbReference type="EnsemblBacteria" id="ARF82339">
        <property type="protein sequence ID" value="ARF82339"/>
        <property type="gene ID" value="B6264_28785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36368">
        <property type="protein sequence ID" value="OEV36368"/>
        <property type="gene ID" value="HS99_0029870"/>
    </dbReference>
    <dbReference type="OMA" id="TWSAMSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="47314" checksum="E114D4A90D6AB9F4" modified="2017-01-18" version="1">MRARPGRLRSLLVGLCAGATVIALTTGPAQAAPVGTAVPAGPAARADAAYAISTPTNISAPCSGQNAETIQAVDPAVNAVYDAWMGCKGIGFAGSRDGGSTFGSPLTLPGSTGQNGSRSWDPAITVAPDGAIYVAFMVARSGLTFPVVDVSTDHGASFKTAGQITPPDANNWGDRDFVTAGPDGTLYLTWDYGPSAAAVTFVCAASGSCSFATGDVNAVLQKSTDGGRTWSAMSHISPGYPNSGADSAPVTVEADGSIDVLYQGYVVTDVPTDNLTVAHTYATRSTDGGATWSPPVRVGGGAGSMNNSEWWIDGSEALGPDGTLYATWDTQGSNSDTGWLSYSQDHGATWSTPVQVPSDTLNVPHVMQVVAGPPGTAYVGWLSSSDPRGYAQYLRTFLTTRGWLSAPVRVSRNFGTSTVWPGDTFGFSAPAPDRLVLAWGSAVAPTASNDSIWAATVGVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6S8</accession>
    <name>A0A1E7N6S8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8124"/>
    <dbReference type="EnsemblBacteria" id="OEV36163">
        <property type="protein sequence ID" value="OEV36163"/>
        <property type="gene ID" value="HS99_0030385"/>
    </dbReference>
    <dbReference type="OMA" id="WAHRWYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198820" evidence="1">
        <location>
            <begin position="32"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="2">
        <location>
            <begin position="95"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="783" mass="85513" checksum="52D55E9D44866382" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K8</accession>
    <name>A0A1E7N7K8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7776"/>
    <dbReference type="EnsemblBacteria" id="ARF82292">
        <property type="protein sequence ID" value="ARF82292"/>
        <property type="gene ID" value="B6264_28510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36624">
        <property type="protein sequence ID" value="OEV36624"/>
        <property type="gene ID" value="HS99_0028000"/>
    </dbReference>
    <dbReference type="OMA" id="YIVQRTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16708" checksum="3E9071D9F39F24FD" modified="2017-01-18" version="1">MTTSRATLDGDRPGIGPTLPPGGQRRRLHLAGLPKPVARARAYTAQAVADWSWPTGDSGGEDDIVLLVAELVANAMLHAGGPVDLVLDASETRLRIEVSDRSTVLPEPRRPHRPGLPGGHGLFIVQKAADRWGALPHADGKTVWAEIDPRPPHPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P8</accession>
    <name>A0A1E7N7P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7785"/>
    <dbReference type="EnsemblBacteria" id="OEV36711">
        <property type="protein sequence ID" value="OEV36711"/>
        <property type="gene ID" value="HS99_0028045"/>
    </dbReference>
    <dbReference type="OMA" id="GLQVWPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="29627" checksum="CD99AACE2BA520D3" modified="2017-01-18" version="1">MAAAFAEAGVTGLLHARDLDTGAELALGADTPVSTASVHKLCLLVTLYREAAAGRIDLTRPVDLPATGRTPGRTGLSAMLDAARLSLRDLAYLALAVSDNAAADVLWDEIGLDTVNRTMAELGLTRTIAVHTVRELFAALAEDTGQDSPVDPAVVARLRVLDPAFTNRSTAREMTALLAALWHGDACPGEPGAALRRLLGLQVWPHRLASGFPFDDVRVHGKTGTLPTLRHEVGVVEYPDGGRYALAVFTRAAATSITLPTADAAIGTAARLAVDALRLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N836</accession>
    <name>A0A1E7N836_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="6" type="ORF">HS99_0026655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282079.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6432"/>
    <dbReference type="EnsemblBacteria" id="ARF78702">
        <property type="protein sequence ID" value="ARF78702"/>
        <property type="gene ID" value="B6264_07030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36852">
        <property type="protein sequence ID" value="OEV36852"/>
        <property type="gene ID" value="HS99_0026655"/>
    </dbReference>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="39921" checksum="099C18658022FD66" modified="2017-01-18" version="1">MFEAVEELLVEHADLEKRLADPSVHADQNNARKLAKRYAELTPITRVYRQWRQAGEDIEAARELAAEDPEFISEVKDSEARREELTEELRLLLVPRDPSDDKDVILEIKAGEGGEESALFAGDLLRMYLRYAERVGWKTEIIDSNESDLGGYKDVSVAVKTKGNAEPGQGVWARLKYEGGVHRVQRVPATESQGRIHTSAAGVLVTPEAEEVEVEILANDLRIDVYRSSGPGGQSVNTTDSAVRITHLPTGIVASCQNEKSQLQNKEQAMRILRSRLLAAAQEEAEREASDARRSQVRTVDRSERIRTYNYPENRISDHRTGFKAYNLDQVLDGELNAVIQSCVDKDAAAKLAAAQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N850</accession>
    <name>A0A1E7N850_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550754.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36643">
        <property type="protein sequence ID" value="OEV36643"/>
        <property type="gene ID" value="HS99_0028135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="6871" checksum="1788F6F47078B2BE" modified="2017-01-18" version="1">MRQVGGPVAVAGVGRRESGDGIEHGLQPAPQALISIVTECATVLALLAAGYLTVRHGKLPASRPPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N860</accession>
    <name>A0A1E7N860_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6453"/>
    <dbReference type="EnsemblBacteria" id="ARF78683">
        <property type="protein sequence ID" value="ARF78683"/>
        <property type="gene ID" value="B6264_06925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36871">
        <property type="protein sequence ID" value="OEV36871"/>
        <property type="gene ID" value="HS99_0026760"/>
    </dbReference>
    <dbReference type="OMA" id="HIRGDHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11302" checksum="5846AB39B6A6C9CF" modified="2017-01-18" version="1">MRITGDHTALAIEGRLDVRTAADARVLLHQAVDGGLGDLVLDLARLEFWDATGLGVIMGTHRRAGRIGRRLVLRSVPAQLQRLLVATKLHRILAVDGGIAEAHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N873</accession>
    <name>A0A1E7N873_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282037.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6450"/>
    <dbReference type="EnsemblBacteria" id="OEV36868">
        <property type="protein sequence ID" value="OEV36868"/>
        <property type="gene ID" value="HS99_0026745"/>
    </dbReference>
    <dbReference type="OMA" id="RRIPWIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="184"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="42649" checksum="63601E81D8C4F2C6" modified="2017-01-18" version="1">MLVPSLPPRRLDRLIALCGLLGGAVLIAFRVYDRADRVPWWAVALPLVVTAGLELVRRTRPVLAVSLGGLAFAGSVFAGGLLATTIMYTDLLYAAVLYGSRRMSRVLHLTGGATVLVLSSLVWYAAGTSEGLLIVVLSSLVFLAPVWTGDLVRRHRQEAETERLRAEQTALLSEMDRREAVGAERARMARELHDVVANHLSAIAIHATGAQSVARRRRLAADDPLVEVLAVIRENSVQGLAEMRRMIGLLRDSGGGEADESYAAPDLAAVDALLAKARAAGQDVGLEFRLTELGERGAVPVPVGLAAYRIVQESLTNALKHAGPGLVAVRLEFGREELLIGVDSPYRGEPGRELPGARAGLVGMSERAGLLGGSFEAGPRDGYWSVRAVLPRGGESEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X0</accession>
    <name>A0A1E7N8X0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37131">
        <property type="protein sequence ID" value="OEV37131"/>
        <property type="gene ID" value="HS99_0004750"/>
    </dbReference>
    <dbReference type="OMA" id="QRINAEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12982" checksum="1C6C061887E7EF2A" modified="2017-01-18" version="1">MTTTASPDTPDKLDDDDYPAYTMGRAAEMTGTTPGFLRALGEHRLITPLRSDGGHRRYSRYQLRIAMRARDLVDQGTPIEAACRIVVLEDQLEEALRLNEQLRRSRHGQEPPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A0</accession>
    <name>A0A1E7N9A0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TolB-like translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1309"/>
    <dbReference type="EnsemblBacteria" id="OEV37259">
        <property type="protein sequence ID" value="OEV37259"/>
        <property type="gene ID" value="HS99_0005525"/>
    </dbReference>
    <dbReference type="OMA" id="GHSYAAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198989" evidence="1">
        <location>
            <begin position="38"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="35925" checksum="814D4375D8265E80" modified="2017-01-18" version="1">MSGGRRFLVLLAAVALLAATGTLAVLHAAGQARGARADGPPVRAGTVTLGAQPDGPRLVFRSMTWGPDRDELASVPLRHPDDTRTAASAPTCLRFHAAAGTGICLQAVYGLVQDGYRAVVLDAALHEVRHYDLAGIPTRARVSPSGHLVAWTVFLSGDSYAGGSFSTRTSVLDTRTWTLQENLEDDAVTLDGAPYRSPDVNVWGVTFADDERFYATVATGGRTYLAAGDVTRRTLTTVHGNVECPSLSPDGTRIAYKKRVPGLPDDAPWRLYVLDLRTMAESATAEQRDVDDQALWLDGRTLAYALPGDDGTDVWSVPADGSGAPALLVHAALAPAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B5</accession>
    <name>A0A1E7N9B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37287">
        <property type="protein sequence ID" value="OEV37287"/>
        <property type="gene ID" value="HS99_0005705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13055" checksum="D5556694E3B4A737" modified="2017-01-18" version="1">MPSVVGLLEQRELAVRRRVDELLEEADGIQAELAVAERDWKEWVIARYRVGEVLAPTDGGVADLGSSEDLRDPGEPGMRPEAPGAAKPKSVVADVALRAGLVGIFGGRGFSRERGQAIARHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C3</accession>
    <name>A0A1E7N9C3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387225.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1261"/>
    <dbReference type="EnsemblBacteria" id="OEV37300">
        <property type="protein sequence ID" value="OEV37300"/>
        <property type="gene ID" value="HS99_0005780"/>
    </dbReference>
    <dbReference type="OMA" id="PEYRGEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="708" mass="74607" checksum="3BBD8659DE0FE800" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA17</accession>
    <name>A0A1E7NA17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286526.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1152"/>
    <dbReference type="EnsemblBacteria" id="OEV37540">
        <property type="protein sequence ID" value="OEV37540"/>
        <property type="gene ID" value="HS99_0026400"/>
    </dbReference>
    <dbReference type="OMA" id="WGERYFQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="14005" checksum="6FFB947FAF041453" modified="2017-01-18" version="1">MQITDTAVSLTVEDTGTSAAFLRRHFGYTEQMSADGFVSLAHPGGGVNVVYLRRGLEVLPEEQRHRTADGVVLAFVVEDIAAEERRLREEGVAITLPLREEPWGEKLFQVTDPNGVVVELVEWVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA66</accession>
    <name>A0A1E7NA66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0026605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1111"/>
    <dbReference type="EnsemblBacteria" id="OEV37576">
        <property type="protein sequence ID" value="OEV37576"/>
        <property type="gene ID" value="HS99_0026605"/>
    </dbReference>
    <dbReference type="OMA" id="PRGMLIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="464" mass="50503" checksum="7D1F4077B362D086" modified="2017-01-18" version="1">MREFGLKRWTRQANPAGPESGPANGRPNSWTVAAVCVAVLSLTAFVVQRHLHGANMVDMLVYRAEGQAVVNGDDLYAMRLPGWDLPATYPPFAAMLFVPSTWFDVSPLRILVMLGNYALLGLAVHLSLKLAGWPARRYRPAATVLATGLGVWLEPVYTTFQYGQVNLAILCLVLWDLTRPDRSRFKGVGIGLATAIKITPGLFTVYLILTGRIRAALVSIGTFLAAGLIGWVALPDGSYGFWTKYLWDPSRVGVTVLVDNQSLRGAVCRLLDANDPGTVGLIATGLVAALGLGVAVLAGRSVRVLRRADAWGGVCTALTALLVSPISWTHHWVWCIPLIALLAAEARSTGRRVLLGATLLVFLSHVMWAVPHRWGRGVAWYWQLPGAIYPPLGIAVLVVIGLRLYRARRQEADASAGAWALLGARLDPDADRDLDLALDRDRDRGPEHDTEHDPARDRALTNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK7</accession>
    <name>A0A1E7NAK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gabD2</name>
        <name evidence="2" type="ORF">HS99_0025870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553120.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4914"/>
    <dbReference type="EnsemblBacteria" id="ARF79986">
        <property type="protein sequence ID" value="ARF79986"/>
        <property type="gene ID" value="B6264_14660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37727">
        <property type="protein sequence ID" value="OEV37727"/>
        <property type="gene ID" value="HS99_0025870"/>
    </dbReference>
    <dbReference type="OMA" id="KARLHAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="57499" checksum="8421F888DF445260" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT2</accession>
    <name>A0A1E7NAT2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7091"/>
    <dbReference type="EnsemblBacteria" id="OEV37754">
        <property type="protein sequence ID" value="OEV37754"/>
        <property type="gene ID" value="HS99_0024460"/>
    </dbReference>
    <dbReference type="OMA" id="TRFQAGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="35214" checksum="9FFEDACD88C6F6CE" modified="2017-01-18" version="1">MGLAEPDGQVYAALVANPQSTAEELAESCALTFQQCVRALDRLAQQGMATRAPVDRERYLPVAPDVAIGTLIGHRESELRHARAEMHRLMDAFREASRYTDPAHSVEVLTGGEAIAQRLEHITGTSQYQVRGFDRPPYIQDPVAAMPLQRRRLREGLRFRTIYDRDAVAWPGRLEKNIMVGVADGEEARVRPTLPMKMIISDDRMAVIPISVGDSVLDAAYVIHPSALLQALDTLFEAEWERAVQLQAAIGTGEASPEPDADHRKLLGLLAAGLTDESIARSLGWSARTTQRRLQALMRSLGATTRFQAGMAARERGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB38</accession>
    <name>A0A1E7NB38_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37864">
        <property type="protein sequence ID" value="OEV37864"/>
        <property type="gene ID" value="HS99_0024760"/>
    </dbReference>
    <dbReference type="OMA" id="FQLNTVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="148"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="40491" checksum="98D4D11ACDA69E9F" modified="2017-01-18" version="1">MDLPSTTGKRETRRRSGFSDQSAALTALQNFLLAERTGIAVDEALTVADYLREWLLSKQEILKATTYAGYERHVRHDLIPAFGPLPLADLRDRHVTTWSRRQLAAGRGRPTVHRCCSILSSAMNAAVSADLLARNPARNAAMKRPAAPERLCWTPQQASAFLHHNAETYNDVYADIFEVILGTGMRRGEVLGLHWPDIHFQRRVLFVRWTLASVNNARLHLQAPKTRASRNWVSLSPRVTAALRRQAARRRSTHPDQPRLQGMVFTRPDGKPINPERLLHTLRQRSAEIGLPKIGLHDLRHTAATIMISSQVPLAVVSKTLRHSTLATTVNIYGHLLPQAAREAVTALADALDHADLPRKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB80</accession>
    <name>A0A1E7NB80_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLATT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552065.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2058"/>
    <dbReference type="EnsemblBacteria" id="OEV37950">
        <property type="protein sequence ID" value="OEV37950"/>
        <property type="gene ID" value="HS99_0024105"/>
    </dbReference>
    <dbReference type="OMA" id="ELYRWVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040688">
        <property type="entry name" value="SLATT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18183">
        <property type="entry name" value="SLATT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLATT_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="28615" checksum="A3472505DC2C98A5" modified="2017-01-18" version="1">MQPEESAWGKEIGEEDQPAAAVARRATTRRRTDLSARQFPLGDWGEPAERLEELYRWSEERAVEAIEWYRRDRIWKRRWARLLRFGSAGFAVGGVTAPLVDLTDAVAHGTSWGYVGLALSAACYGADRVFGLTSGWMRDVSTGQALQRRLEAFQFDWASECVREVLGPTEGTAGEAAERCLGVLRRFCEDVSDMVRTETSEWMLEFRASMTRLPTQTAGTWGGRTEPGAGAQVRVLPPPGTRPTMPRQRPPEGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP5</accession>
    <name>A0A1E7NBP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288470.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000249.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3017"/>
    <dbReference type="EnsemblBacteria" id="ARF79711">
        <property type="protein sequence ID" value="ARF79711"/>
        <property type="gene ID" value="B6264_13065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38078">
        <property type="protein sequence ID" value="OEV38078"/>
        <property type="gene ID" value="HS99_0023035"/>
    </dbReference>
    <dbReference type="OMA" id="GAGANDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="10123" checksum="725EB107E26E9B1E" modified="2017-01-18" version="1">MSRIRAAAAVTALGAFLLVGVGATTAHADNGAGANDHSNSSVVSDAGSGNVIGTVAGNVANTQQTATGSGASNQNNGLAVTGNGGSIGALQGNGNVGARVSYPHVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBQ2</accession>
    <name>A0A1E7NBQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5936"/>
    <dbReference type="EnsemblBacteria" id="OEV38122">
        <property type="protein sequence ID" value="OEV38122"/>
        <property type="gene ID" value="HS99_0023270"/>
    </dbReference>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="225"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="719" mass="76652" checksum="A8C3ABAC4546234F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBQ8</accession>
    <name>A0A1E7NBQ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288458.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3010"/>
    <dbReference type="EnsemblBacteria" id="ARF79705">
        <property type="protein sequence ID" value="ARF79705"/>
        <property type="gene ID" value="B6264_13030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38084">
        <property type="protein sequence ID" value="OEV38084"/>
        <property type="gene ID" value="HS99_0023070"/>
    </dbReference>
    <dbReference type="OMA" id="CGPGQWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22822" checksum="515CED0DD4127A58" modified="2017-01-18" version="1">MENVHGRVRGSYDAVAEEYLERIGGELAHKVVDRALLSAVLEEAAGGVVADLGCGPGHVAGWLAGQGARVVGIDLSPRMVELAGREHPEAAFRTGDLLALPAGDGEFAAAVALYSVIHLEPDELLPAFVEMRRVLRPGGVLLVSFHLGKEVRRLEEWWGHRVHVDFHFLETDAVADRLAEAGFAVEARLERVGLPEEADTRRGYLLARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS1</accession>
    <name>A0A1E7NBS1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288113.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7141"/>
    <dbReference type="EnsemblBacteria" id="ARF79650">
        <property type="protein sequence ID" value="ARF79650"/>
        <property type="gene ID" value="B6264_12695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38140">
        <property type="protein sequence ID" value="OEV38140"/>
        <property type="gene ID" value="HS99_0023395"/>
    </dbReference>
    <dbReference type="OMA" id="MANNQQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="27074" checksum="82A6EBDB4E69D674" modified="2017-01-18" version="1">MSTTPETRERALRLRELVAEGVLVLPNAWDAGSAAVIASAGARAIATTSGGVSWSLGHGDGQRMDRAAAVEAARRVVAAVDLPVTVDAEGGYGPLAADVAATVTALVGVGAAGVNLEDSTAVGGPLFPVAEQAGRLRAARTAAAAAGLPELLVNARTDVFLFGLGGLDDVLVRAEAYAEAGADGLFVPGLLDLDVLTELCRRSPLPVNAMAGAGGPGVAELAATGVRRVSVGTGLAQAAYTTAHRAAVELLGAGTLTELDGALGFGELNGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT0</accession>
    <name>A0A1E7NBT0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557829.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000474.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7128"/>
    <dbReference type="EnsemblBacteria" id="ARF79640">
        <property type="protein sequence ID" value="ARF79640"/>
        <property type="gene ID" value="B6264_12640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38151">
        <property type="protein sequence ID" value="OEV38151"/>
        <property type="gene ID" value="HS99_0023450"/>
    </dbReference>
    <dbReference type="OMA" id="NRHKVRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="25341" checksum="2736574B57918382" modified="2017-01-18" version="1">MTDRDGAPDPEHPAPGLVLTTPGGRSFLFDPGALCLELLTTGGPGDLSRFEALHRPSDLTDWLPRSRLRLPAGAVRITAEQLTDARTLRDALWRLATARAHGTTGTVADHAADHAALNRAAAHPPLVPQIGPDGTAAAPLPADGAQLVSTLARDAIALLAGPYADRIRECGAHNCRLLFVDTSRPGRRRWCSMERCGNRNKVRALRARRDSEDSAAGVVPAAGTAPTAGAVPAAGHRTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM3</accession>
    <name>A0A1E7NCM3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0021090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene274"/>
    <dbReference type="EnsemblBacteria" id="ARF82202">
        <property type="protein sequence ID" value="ARF82202"/>
        <property type="gene ID" value="B6264_27965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38408">
        <property type="protein sequence ID" value="OEV38408"/>
        <property type="gene ID" value="HS99_0021090"/>
    </dbReference>
    <dbReference type="OMA" id="IRIHYVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="32692" checksum="E56249328F6DA814" modified="2017-01-18" version="1">MAPRTIRRAVIPAAGLGSRLLPLTKATPKEMLPVGDKPVIEHTVRELIESGITDITIVVNGDKGLIQEHFRPNPVLVDQLRRDGKAAFADAVEEVGELSRKGHISYLYQHGPYGNGTPVLNAARHFGDEPCLVLWPDDVFVAEVPRAQQLIRAYEQTNAPVLALMPMAPEDSYRYGVPVVKEDLGGGSLRITGLVEKPKPADAPSGYAAIGGYVITPGIVDELRELTRRWLEKPEDEVYLTDAINAYAARRAVYGQVIAGTWYDTGNPAAYLRAQFAAALANPEFGHELRQLAGELAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDA6</accession>
    <name>A0A1E7NDA6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829275.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000437.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1787"/>
    <dbReference type="EnsemblBacteria" id="ARF77700">
        <property type="protein sequence ID" value="ARF77700"/>
        <property type="gene ID" value="B6264_01085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38667">
        <property type="protein sequence ID" value="OEV38667"/>
        <property type="gene ID" value="HS99_0020670"/>
    </dbReference>
    <dbReference type="OMA" id="YTAVHEK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="37508" checksum="7734041BFCA4F1F0" modified="2017-01-18" version="1">MPPTPHQGHVVVAPDKFKGTLEGAEVAARIAAGIRRAAPGTEVRELPVADGGEGTLAAALAAGFDRVPAKVAGPTGLPVDAALAVRGDTAVVELAQASGLARLPGGRTAPLAAGSYGVGQLIGRAVSRGAKRIVLGLGGSACTDGGAGMVQALGVSLRDADDVELPPGGAALRRLERIELGPLAGLLTGVEVVVACDVDNPLLGPRGATAVYGPQKGADGDDLVVLEEGLTRFADQVAAVTGRDVRQAPGAGAAGGVGFAALALLGATMRPGIELLLELLGFDEAVRGARLVVTGEGCLDAQTLHGKAPAGVAAAAARAGVRVAAVAGRLELSEPEWRAAGFTAAIALTDLAEQPGDSMTRAGELAEVAGEQLAGALLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDK1</accession>
    <name>A0A1E7NDK1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="11" type="ORF">HS99_0019045</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7360"/>
    <dbReference type="EnsemblBacteria" id="ARF81177">
        <property type="protein sequence ID" value="ARF81177"/>
        <property type="gene ID" value="B6264_21775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38770">
        <property type="protein sequence ID" value="OEV38770"/>
        <property type="gene ID" value="HS99_0019045"/>
    </dbReference>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="679"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="889" mass="95467" checksum="F9C30B993672B2CE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR0</accession>
    <name>A0A1E7NDR0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF948 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033349866.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000458.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7358"/>
    <dbReference type="EnsemblBacteria" id="ARF81176">
        <property type="protein sequence ID" value="ARF81176"/>
        <property type="gene ID" value="B6264_21765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38768">
        <property type="protein sequence ID" value="OEV38768"/>
        <property type="gene ID" value="HS99_0019035"/>
    </dbReference>
    <dbReference type="OMA" id="FSYGVRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="16502" checksum="E9D188914BDE2C89" modified="2017-01-18" version="1">MTVGELAGLLVAVFWAVLVTLLAVVLVRLSRVLKEATVLVSAVTEQAVPLLTEAGAAVRSANEQLDRVDEITANVQDAAANAKALSSTAAATLGGPLMKVAAFSYGVRKAVAKQQGALPNVPLQAGERDELARLIRAEVRAATAPRGGLLSRVRRAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI3</accession>
    <name>A0A1E7NEI3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6302"/>
    <dbReference type="EnsemblBacteria" id="ARF83339">
        <property type="protein sequence ID" value="ARF83339"/>
        <property type="gene ID" value="B6264_30950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39110">
        <property type="protein sequence ID" value="OEV39110"/>
        <property type="gene ID" value="HS99_0018675"/>
    </dbReference>
    <dbReference type="OMA" id="DREWIGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="21733" checksum="DFA03667F45AD3D4" modified="2017-01-18" version="1">MFVTTGQAGTALGCSIPTVKKLMATGVVPGVRETGRQVFPLAALQALQGRPVADLTVLGAPEVAVLRSDAPAKVDESDREWIGFGTALDRGQLLAALSGWWRCDPARVAAGGVLPVTVAGFVVAVLTGLAEWESDGTVGTAGRFRFPKARLAGYLTDLTAPANAATPTDPQDARLAGLLLGTRLPSVSGGPIAYVPTTTAVDQPDTEGGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEM1</accession>
    <name>A0A1E7NEM1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1020"/>
    <dbReference type="EnsemblBacteria" id="OEV39147">
        <property type="protein sequence ID" value="OEV39147"/>
        <property type="gene ID" value="HS99_0018265"/>
    </dbReference>
    <dbReference type="OMA" id="LACATIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="16019" checksum="DA19B52359F13739" modified="2017-01-18" version="1">MISDGGGIPFHVITTAANVNDVTQTLALVDGIPQVAGRVGRPRKRPDALLGDKGYDSNPNRRELRKRRILPVISRRGEPDIIGLGKLRYVVEQTFAQLHQFKRLAVRWERRLDLHEALVSLACATICWRRLRRPAQPTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF09</accession>
    <name>A0A1E7NF09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550238.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000486.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3627"/>
    <dbReference type="EnsemblBacteria" id="OEV39290">
        <property type="protein sequence ID" value="OEV39290"/>
        <property type="gene ID" value="HS99_0000810"/>
    </dbReference>
    <dbReference type="OMA" id="DAVFWLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="31224" checksum="B9958E3155ABEF8F" modified="2017-01-18" version="1">MIVVTAPTAKIGRRVVEQLLDAGEPVRVIVRDPQRLSPTVRDRVEIVEGSHRHAAAVDKAFAGADAVFWLMPSDLSAPDVMTSYVENSRPGVEAVAAHGVRHVVGVSALGRGTAVADRAGHVTASLAMDDLFATVTNYRALANPTFMDNTLRDIRTILGAGLISGPLAPDRKLPLVATRDIGGAAARLLLDRDWTGFAEVPVLGPEDLSGNDMAAVITDVLGIPVRYAQVEAASLEAAMLSFGASPGMARAMADMATAKIEGLDEGVVRTTGNSTPTTFRQWCTEVLRPAVDAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD2</accession>
    <name>A0A1E7NFD2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367022.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7527"/>
    <dbReference type="EnsemblBacteria" id="OEV39416">
        <property type="protein sequence ID" value="OEV39416"/>
        <property type="gene ID" value="HS99_0001575"/>
    </dbReference>
    <dbReference type="OMA" id="EAYFTHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="835" mass="87812" checksum="FB7B2797E5EF1E6B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFQ6</accession>
    <name>A0A1E7NFQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481135.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6757"/>
    <dbReference type="EnsemblBacteria" id="OEV39541">
        <property type="protein sequence ID" value="OEV39541"/>
        <property type="gene ID" value="HS99_0002320"/>
    </dbReference>
    <dbReference type="OMA" id="LGERTEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="18074" checksum="BFE3378A08F8E3DB" modified="2017-01-18" version="1">MNAEPPSDALRPVRAELLRTARADADVILSEARRDADRTLAAARTEAEAILGRARQDGAADGRAAARQELTRARSAARNAELAARGAAYAELRRRITARLRELCQADPAYGERLAARARSLLGPDARVVGHPDGGVLATAPGRVVDLGLPAVTDRALERIGSDAEALWEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT3</accession>
    <name>A0A1E7NFT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39534">
        <property type="protein sequence ID" value="OEV39534"/>
        <property type="gene ID" value="HS99_0002285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13473" checksum="A80B9CC356EB30F3" modified="2017-01-18" version="1">MEDSRRPRSTPVASRVQVPGCEGGPLGAHRVDGGLVDQVGQVRAREAGGGTGDPIQVHAGARVLPCTWTERMAERSAWLGSGTVTWRSNRPGRSSAGSRASGRLVAGRLVAARTTMPVDWSKPSISASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV1</accession>
    <name>A0A1E7NFV1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555611.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6742"/>
    <dbReference type="EnsemblBacteria" id="OEV39552">
        <property type="protein sequence ID" value="OEV39552"/>
        <property type="gene ID" value="HS99_0002390"/>
    </dbReference>
    <dbReference type="OMA" id="RDRHLPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="42266" checksum="DC8CAF25C0714BA1" modified="2017-01-18" version="1">MTSSAPATGPGELRRHLGVFDAVVIGLGSMIGAGIFAALAPAASAAGSGLLLGLGLAAVVAYCNATSSARLAARYPRSGGTYVYGRERLGDFWGYLAGWGFVVGKTASCGAMALTVGSYVWPQQAHAVAVAAVVALTTVNYLGVQKAAWLTRAIVAVVLAVLAAVVTACLTGDNVDTGHWAVGTDAGFRGVLQAAGFLFFAFAGYARIATLGEEVRDPRRTIPRAIPLALGITLVVYAAVALAALAVLGPDRLAHAGAPLTEAVRAAGAPGLAPVVRVGAAVAALGSLLALILGVSRTTLAMARDRHLPHVLAAVHPRFAVPHRAELTVGAVVAVLAAVADVRGAIGFSSFGVLAYYAVANASAWTLTPSEGRPPRVVPVFGLAGCVVLAFALPGASVLGGAVVLALGAAAYGVRKALSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF0</accession>
    <name>A0A1E7NGF0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279602.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000236.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2950"/>
    <dbReference type="EnsemblBacteria" id="OEV39776">
        <property type="protein sequence ID" value="OEV39776"/>
        <property type="gene ID" value="HS99_0003765"/>
    </dbReference>
    <dbReference type="OMA" id="FIKHDGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="19204" checksum="E8AEB80DFBD7C868" modified="2017-01-18" version="1">MQREITVRVDGTARPLTVDTRTTLLDALRERLGITSPKKGCDHGQCGACTVLSGGRRVLSCLTLAVTQDGAEVVTAEGLAPGAAGAGQQLEGGLHPVQRAFVDCDALQCGYCTPGQVVSAVGALDEFAAGWPSAVTEGPGAPGLDRAEVAERMSGNLCRCAAYVNIVTAVLRAATSLPAGPTAGKEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI9</accession>
    <name>A0A1E7NGI9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0003590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550488.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2915"/>
    <dbReference type="EnsemblBacteria" id="OEV39745">
        <property type="protein sequence ID" value="OEV39745"/>
        <property type="gene ID" value="HS99_0003590"/>
    </dbReference>
    <dbReference type="OMA" id="QNDSRMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199141" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="32"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="14">
        <location>
            <begin position="659"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV39745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="849" mass="89831" checksum="11E61252EA45E2E6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL4</accession>
    <name>A0A1E7NGL4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000456.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5048"/>
    <dbReference type="EnsemblBacteria" id="OEV39834">
        <property type="protein sequence ID" value="OEV39834"/>
        <property type="gene ID" value="HS99_0002135"/>
    </dbReference>
    <dbReference type="OMA" id="WNQPEVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="553" mass="61328" checksum="F1CEED2976053FDE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP0</accession>
    <name>A0A1E7NGP0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286021.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene560"/>
    <dbReference type="EnsemblBacteria" id="OEV39818">
        <property type="protein sequence ID" value="OEV39818"/>
        <property type="gene ID" value="HS99_0001500"/>
    </dbReference>
    <dbReference type="OMA" id="HAHAIGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9746" checksum="54C75A1992A9CF3F" modified="2017-01-18" version="1">MTLHADPHLALVRPVQPLTPEGCQECLMLGSPWVHLRLCLTCGHVGCCDSSPNKHARRHAAVVAHPIVQSFQPGEEWRWCFVHEAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVB6</accession>
    <name>A0A1E7MVB6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367087.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6957"/>
    <dbReference type="EnsemblBacteria" id="OEV32365">
        <property type="protein sequence ID" value="OEV32365"/>
        <property type="gene ID" value="HS99_0016840"/>
    </dbReference>
    <dbReference type="OMA" id="HRVEGRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="5">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="497"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="796" mass="83309" checksum="D65C154A8DA90C5D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVC9</accession>
    <name>A0A1E7MVC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553877.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000487.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6987"/>
    <dbReference type="EnsemblBacteria" id="OEV32389">
        <property type="protein sequence ID" value="OEV32389"/>
        <property type="gene ID" value="HS99_0016985"/>
    </dbReference>
    <dbReference type="OMA" id="GYEVTLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Smoa_sbd" evidence="2">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="413" mass="44237" checksum="B92C84D61C13EAA0" modified="2017-01-18" version="1">MRRILIVGAGQAGLQLALGLQSHGYDVTLLTDRDAQEVRGGRVLSTQCMFDSALRTERALGLDLWAGQAPRIEGVGVSVGGPESAPVIDWVGRLDACAQSVDQRLKTSTWLDAFAARGGRVEVRQVSAADLEHLAGSYDLVLVASGKGKLASLFERDEERSPYQRPQRALAVSYVYGLAPRPEQDFPVVRCNLVPGIGEFFTMPALTAAGPCDILFWEAQPGGPADAFDGIHDPAEHLRVMLELMKTFTPWEYDRARSGVELTDAGATLAGRFTPVVRRPVGELPGGEAVLGVADVVVTNDPITGQGANNAAKCAALYLEAILAHGDKPFDRDFQQSAFDRFWADTARAVTTWTNAMLAPAPPHAVELFAAAGELPTVADRFANCFNDPADVEGWLLDPEKAAAYLASVAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI0</accession>
    <name>A0A1E7MVI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557431.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1183"/>
    <dbReference type="EnsemblBacteria" id="OEV32439">
        <property type="protein sequence ID" value="OEV32439"/>
        <property type="gene ID" value="HS99_0017305"/>
    </dbReference>
    <dbReference type="OMA" id="VYVSAWC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30466" checksum="811DF53ACDC12715" modified="2017-01-18" version="1">MQPTFVLVHGAFANSFSFAPLQAELGLLGHRSVAVDLPGHGFAATYPGAYQAPQDLAGLACAPGAIKGVTLADNAAHLIGILERAKRNGPVILVSHSRGGVTATVAANRRPDLIDRIVYVSSWCPVDLDVSAYYAEPEMAAVDARGLASAMVGNPAELGLLRCNFRTADPGVLASFKAAFLADGTDEEFMVFLNTFQPDENLDAGTPDDRAQADSWGRIPRTYVRLSEDTSVPPAMQDRMIREGDALTPQNPYDVRTLTSSHLKWLVDPAPAARVLAEVAALLPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM5</accession>
    <name>A0A1E7MVM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835638.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1222"/>
    <dbReference type="EnsemblBacteria" id="OEV32475">
        <property type="protein sequence ID" value="OEV32475"/>
        <property type="gene ID" value="HS99_0017495"/>
    </dbReference>
    <dbReference type="OMA" id="LIVTHNC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="359" mass="37755" checksum="45A8FC0EFDC46155" modified="2017-01-18" version="1">MTPPAVHPAASRRARRRDRTVYLRSHPLLFALLCATRHRPVLRLGRTLIVHDPDAYRHALTRIPLERTAPGTTGGAAAQFTGGRILFDQDGDDHRAARRALTTDLAAPALSRLRPLWQDVLAERVPALATGTLELVDLAEELAAATAAALTGTDAPPRELARAAREAAAATARDHLPGPRPPRGTDAAEAAARLTALLPDPRDAMLAVAAVNTTVAALPRAAAWCADARLWPAVDATSAPALAAELLRLTAPSPLLPRAAAANATLAGHPVRAGDRLVLVARHAARAHHRTPPQDPAATQAVFGTGAHACPGAALARAQLADTLLALAPHRPRVVRARVDRHAALPGYAHLTLRAEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW11</accession>
    <name>A0A1E7MW11_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557440.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1201"/>
    <dbReference type="EnsemblBacteria" id="OEV32453">
        <property type="protein sequence ID" value="OEV32453"/>
        <property type="gene ID" value="HS99_0017380"/>
    </dbReference>
    <dbReference type="OMA" id="YAYYFDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19021" checksum="80767D8A2825DC7C" modified="2017-01-18" version="1">MTGSRDTVLVVVRGPSGAGKSSVAAGLRAAYGRGLALVGQDLLRRTVLRERDVPGGANIGLISLVARHALDSGFHVVVEGILAAERYGPMLADLVADHRGRSHLYYLDVDFAETVRRHATRSQAAEFSPEDMAGWYRERDLLPGGAERVVPQDSTLAGTVARILADTALTPPGWTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW35</accession>
    <name>A0A1E7MW35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287857.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000296.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3856"/>
    <dbReference type="EnsemblBacteria" id="ARF78325">
        <property type="protein sequence ID" value="ARF78325"/>
        <property type="gene ID" value="B6264_04800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32634">
        <property type="protein sequence ID" value="OEV32634"/>
        <property type="gene ID" value="HS99_0015280"/>
    </dbReference>
    <dbReference type="OMA" id="FFAQKAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="33614" checksum="0C0ED0F4A354959D" modified="2017-01-18" version="1">MTLSSTPTLTEARPGASRTGTAAARAARRRAVLHWVAVHSLAIAAALFFLLPFVFVFLTSVMDDQQALTTDYWPTSWNWGNYGKVWDTPGFLTWWRNTLVYAGAGTLLTVVSSLPVAYALAKFRFRGRNLALMAVIAMMMLPPQVTVIPMYLFWAKQMGLGGSLWPLIIPMAFGDAFSIFLLRQFLMTIPKEYVEAARIDGCGDLRTLLRVVLPMAKPAIAAVALFQFFYCWNDYFGPQIYASNNHQAWTLSYGLESFKAAHHTNWNLTMAATLLVMAPVIVLFFFAQKAFIEGVTLTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA2</accession>
    <name>A0A1E7MWA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S cluster assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7868"/>
    <dbReference type="EnsemblBacteria" id="ARF78256">
        <property type="protein sequence ID" value="ARF78256"/>
        <property type="gene ID" value="B6264_04395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32705">
        <property type="protein sequence ID" value="OEV32705"/>
        <property type="gene ID" value="HS99_0015690"/>
    </dbReference>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="27432" checksum="D5C0196482F3744C" modified="2017-01-18" version="1">MATLEIRDLHVSVEAENGPREILKGVDLTVKQGETHAIMGPNGSGKSTLAYSLAGHPKYTVTGGSVLLDGEDVLEMSVDERAKAGVFLAMQYPVEVPGVSVSNFLRTAATAVRGEAPKLRLWVKEVKEAMAALQMDPAFAERNVNEGFSGGEKKRHEILQLELLKPKIAILDETDSGLDVDALRIVSEGINRVRSTGEVGTLLVTHYTRILRYIKPDYVHVFAGGRIVESGGAELADKLENEGYEAYVKGGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG5</accession>
    <name>A0A1E7MWG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289077.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3796"/>
    <dbReference type="EnsemblBacteria" id="ARF78380">
        <property type="protein sequence ID" value="ARF78380"/>
        <property type="gene ID" value="B6264_05105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32583">
        <property type="protein sequence ID" value="OEV32583"/>
        <property type="gene ID" value="HS99_0014975"/>
    </dbReference>
    <dbReference type="OMA" id="WTEYLHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20333" checksum="D0E40602EA491ABD" modified="2017-01-18" version="1">MRLLGTISPDRPLLVVAVREEAAHLDDRLPVLLTGMGKVNATASLATVLAQGEHPSEVINLGTAGALRPGWEGIHHVVQVIQHDLNSEVLRALTGRSYGDPLVVGRGDGPVLATGDLFVDSPAAKERLAEHADLVDMEGYAVATVAHRAGVPVRLVKYVSDEAGDGAGHTWRESVDDCARHLADWVHAQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP7</accession>
    <name>A0A1E7MWP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0039765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene75"/>
    <dbReference type="EnsemblBacteria" id="ARF80129">
        <property type="protein sequence ID" value="ARF80129"/>
        <property type="gene ID" value="B6264_15450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32866">
        <property type="protein sequence ID" value="OEV32866"/>
        <property type="gene ID" value="HS99_0039765"/>
    </dbReference>
    <dbReference type="OMA" id="CADWHRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="19157" checksum="B82BF9C1FDF04A3D" modified="2017-01-18" version="1">MAKQTRDEEFTVYVASRSGWLRKVAYLLCGDWHRADDLVQETITKLYVNWARASRMENRDGYARRVLVNTFLAEQRSPWWRRTLRSEAGPEGVAGDVDLDASLDLRRALAALPPRQRATVVLRYYCDLSIEQAAETLGCSSGNVKSQSSRALEALRGTLAPRPTAAERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW1</accession>
    <name>A0A1E7MWW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366906.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5794"/>
    <dbReference type="EnsemblBacteria" id="ARF81328">
        <property type="protein sequence ID" value="ARF81328"/>
        <property type="gene ID" value="B6264_22635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32918">
        <property type="protein sequence ID" value="OEV32918"/>
        <property type="gene ID" value="HS99_0013620"/>
    </dbReference>
    <dbReference type="OMA" id="PYWTSYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2121" mass="224398" checksum="ED34F469F4C9A986" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX53</accession>
    <name>A0A1E7MX53_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279847.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000420.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5683"/>
    <dbReference type="EnsemblBacteria" id="ARF81434">
        <property type="protein sequence ID" value="ARF81434"/>
        <property type="gene ID" value="B6264_23215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33018">
        <property type="protein sequence ID" value="OEV33018"/>
        <property type="gene ID" value="HS99_0014185"/>
    </dbReference>
    <dbReference type="OMA" id="TAWLINE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="351" mass="38045" checksum="1AA332441EBC40A7" modified="2017-01-18" version="1">MAVLCKPAIAVPENVITNEETLELARRLHHDHPQLDLALRLIKNTGVRTRHLIQPIDVVLKHPGLDERSAIFEAESKARVPEVVVRALETAQVEPSQIDLIVYVSCTGFMMPSLTAWLINKLGFRPETRQLPIAQLGCAAGGAAVNRAHDFCSAYPGANVLIVACEFCSLCYQPTDLGVGSLLSNGLFGDGLAAAVVRGEGGTGIRLERNGSYLIPNTEEWISYAVRPTGFHFQLDKRVPGTMEPLSPALRAVAEQHQWDVGMLDFYIIHAGGPRILDDLSRFLKVPPEAFRFSRATLTQYGNIASAVVLDALARMFDEESALDGHHGLMAGFGPGITAEMSLGTWASPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR4</accession>
    <name>A0A1E7MXR4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290891.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000834.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5913"/>
    <dbReference type="EnsemblBacteria" id="ARF82075">
        <property type="protein sequence ID" value="ARF82075"/>
        <property type="gene ID" value="B6264_27200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33238">
        <property type="protein sequence ID" value="OEV33238"/>
        <property type="gene ID" value="HS99_0039150"/>
    </dbReference>
    <dbReference type="OMA" id="HDRRRMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="27342" checksum="7BECBFEC73477B4E" modified="2017-01-18" version="1">MPGPIQSLSRAAAIMRLLAGGERRLGLSEVATALDLAKGTAHGILRTLQQEGFVEQDPESGKYQLGAELLRLGQSYLDVHELRARALVWADDLARAAGETVYLGVLHQQGVLIVHHVFRPDDTRQVLEVGSMQPLHSTAIGKVLVAYDPVARGELGDGPYESYTLRTLTGAGELDAECALIRERGWADSVEETWEGVASIAALIQDRRRNPVGAVCINGPVERVCEDGFVKPSLVASVRSAARAISRDLGAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXV9</accession>
    <name>A0A1E7MXV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283823.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000881.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7017"/>
    <dbReference type="EnsemblBacteria" id="ARF80412">
        <property type="protein sequence ID" value="ARF80412"/>
        <property type="gene ID" value="B6264_17200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33275">
        <property type="protein sequence ID" value="OEV33275"/>
        <property type="gene ID" value="HS99_0038980"/>
    </dbReference>
    <dbReference type="OMA" id="QPCAILR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27422" checksum="5EFCEB5FE10885AA" modified="2017-01-18" version="1">MQRIRLRYTKRGRLRFTSHRDFQRAFERALRRSAVPMAYSAGFTPHPKVSYANAAPTGVASEAEYLEIGLAAVRDPEQLRAQLDESLPAGLDVIDAVEVRTPNFVERLEASEWLVRLDGVEPDQAAKAVRTFLAEEKVEVERRTKNGVRVFDARGAVAALEAVEPQVDGGTDTAAGTDRDVRTGRPCAILRLVVRHATPAVRPDDVLSGLRATADLAPPVPAEVTRLAQGPLDEESGTVTDPLALDRAAAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY02</accession>
    <name>A0A1E7MY02_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name evidence="2" type="ORF">HS99_0012000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385975.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7023"/>
    <dbReference type="EnsemblBacteria" id="ARF80418">
        <property type="protein sequence ID" value="ARF80418"/>
        <property type="gene ID" value="B6264_17230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33317">
        <property type="protein sequence ID" value="OEV33317"/>
        <property type="gene ID" value="HS99_0012000"/>
    </dbReference>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="222"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="39233" checksum="9B3B41C6AF467793" modified="2017-01-18" version="1">MSEDSLREEVLTARRIVVKVGSSSLTTAAGGLDADRVDALVDAIAKVRSRPDAPEVVLVSSGAIAAGLAPLGLDGRPKDLARQQAAASVGQGLLVARYTASFARYGIRVGQVLLTAEDASRRAHYRNAYRTLDQLLAMGAMPIVNENDTVATAEIKFGDNDRLAALVAHLVRADLLVLLSDVDGLYDGDPAKPGTSRIAEVRGPHDLDGIEIGSAGKAGVGTGGMVTKVEAARIATGAGIPVVLTAASHATDALAGRPTGTLFLRTGSRTSDRMLWLAHASSPRGALHLDAGAVEAVVSAGASLLPAGVTKVDGEFAAGDPVDLLAENGHIVARGLVNFDARELPRLLGRSTRDLAQEFGAAYEREVVHRDDLVVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY44</accession>
    <name>A0A1E7MY44_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TerB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4030"/>
    <dbReference type="EnsemblBacteria" id="OEV33365">
        <property type="protein sequence ID" value="OEV33365"/>
        <property type="gene ID" value="HS99_0012285"/>
    </dbReference>
    <dbReference type="OMA" id="CGGDRNY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007791">
        <property type="entry name" value="DjlA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05099">
        <property type="entry name" value="TerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerB" evidence="1">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="25423" checksum="FC16054264B8846A" modified="2017-01-18" version="1">MPCLGSGAVTRLWGVRPKWRTDVLGDFFCPGCGGDRNYRRQHGRRWLRLLGTPLLPLGPVIGSVQCTSCHGRYGVEALEQPTSVRLGAMLRDAQYTIALALLAAGGTAHRAAREAACTVVREAGFEDCGEAQVLAALAALSGLGGELHDAHELGAPFGQRLGEAGGLAVELHAVLEPLAPHLAQQGRERLLLQGAAIALADGRYLPQERDALAAVGSCLDLPKSQVPALLEAATRAPYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYK3</accession>
    <name>A0A1E7MYK3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">HS99_0013235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5195"/>
    <dbReference type="EnsemblBacteria" id="ARF80620">
        <property type="protein sequence ID" value="ARF80620"/>
        <property type="gene ID" value="B6264_18455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33517">
        <property type="protein sequence ID" value="OEV33517"/>
        <property type="gene ID" value="HS99_0013235"/>
    </dbReference>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="30230" checksum="75563F14290ECC28" modified="2017-01-18" version="1">MNASSPSPAQNQPANATLYGGVTNRRVTVRDLAAAKQRGEKWAMLTAYDALTAGVFDEAGIPVLLVGDSAGNCHLGYETTVPVTMDQMVMLSAAVVRGTQRAMIVADLPFGSYQESPAQAMHNAARLMKEAGVGAVKLEGGERSARSIELLVEAGIPVMAHIGLTPQSVHAFGGYPVQGRGDEAAHQLLRDAKAVQQAGAFSVVLEAVPAELAAQVTKQLAIPTVGIGGGPETDAQVLVWTDMAGMTAGRVPKFVKKYADLRGVLGEAAREFAADVRTGAFPAEEHSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX5</accession>
    <name>A0A1E7MYX5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555509.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000598.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6566"/>
    <dbReference type="EnsemblBacteria" id="ARF80538">
        <property type="protein sequence ID" value="ARF80538"/>
        <property type="gene ID" value="B6264_17925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33433">
        <property type="protein sequence ID" value="OEV33433"/>
        <property type="gene ID" value="HS99_0012700"/>
    </dbReference>
    <dbReference type="OMA" id="TGPVWEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039480">
        <property type="entry name" value="C-C_Bond_Lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15617">
        <property type="entry name" value="C-C_Bond_Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="397" mass="43216" checksum="19F15D6ED3495A5B" modified="2017-01-18" version="1">MRHFGHLADDVRARLFLEQPRTFTAQSEPAVLATALGGTLYSPATRPALAADIRKLAARGVVSMVLCLEDAIADHEVDAGERNLVEQIADLVSDFTDCTQDHPLLFIRVRTAAQILDLAERLGPAVGLLSGFVLPKFTAEDGGAYLAALAAAEAATGRRLFAMPVLESPELAHLETRREQLFGIAELLAAHRERVLAVRLGVTDLCSAYGLRRSPDLTAYDVALVAAVIGDVVNVLGRADGTGYTVTGPVWEYFPVQERMFKPQLRRTPFAASAGTARASGEEVRRRIIEHDLDGLIREVELDRTNGLLGKTCIHPSHVPAVHALSVVTHEEYCDARDILRQEQDGGGVLRSAYTNKMNEARPHRAWAERVLLRAEVFGVAREDVSFAELLSACLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ10</accession>
    <name>A0A1E7MZ10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4935"/>
    <dbReference type="EnsemblBacteria" id="OEV33667">
        <property type="protein sequence ID" value="OEV33667"/>
        <property type="gene ID" value="HS99_0038440"/>
    </dbReference>
    <dbReference type="OMA" id="MWAFFFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="26367" checksum="4E152168F155DC56" modified="2017-01-18" version="1">MRDHWGAGDRSDARPSERATTEAPTEPRPSPDREGTAEPMSSGDETDERNPFAPPPADAPDQPWRPRSPWSGHGPDGNGGQGGESGGQGGDRPPFPPPWGQGLGEGRPGQRPQAPQPPRLDPTDPSHRKARNAALAGPFALVCLFAGFHWIALLVGVLGIVWGIGALRAKRPAAAAAGGPAGIPAPNPLTPAALAGILTGAMTVVVATSVIGLGYYYRDYVTCVRDSLTNVGAENCDRYAPQWYVDFTGNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ98</accession>
    <name>A0A1E7MZ98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288036.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7704"/>
    <dbReference type="EnsemblBacteria" id="ARF78570">
        <property type="protein sequence ID" value="ARF78570"/>
        <property type="gene ID" value="B6264_06260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33741">
        <property type="protein sequence ID" value="OEV33741"/>
        <property type="gene ID" value="HS99_0038015"/>
    </dbReference>
    <dbReference type="OMA" id="TCPVVHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8181" checksum="51B678E84CC8F72B" modified="2017-01-18" version="1">MVQAYILIQTEVGKATAVAETVSKIPGVITAEDVTGPYDVIVKAEAETVDDLGRMVVAKVQKVEGITRTLTCPVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC2</accession>
    <name>A0A1E7MZC2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3769"/>
    <dbReference type="EnsemblBacteria" id="ARF78405">
        <property type="protein sequence ID" value="ARF78405"/>
        <property type="gene ID" value="B6264_05250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33777">
        <property type="protein sequence ID" value="OEV33777"/>
        <property type="gene ID" value="HS99_0037855"/>
    </dbReference>
    <dbReference type="OMA" id="DMVRQMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="12814" checksum="C4B50BC7657A9F3E" modified="2017-01-18" version="1">MSGHVGIVLVSHSARLAEGLRELLGELAPDGVRVVVAAGTEDGGLGTSYELIAGAIAEADGGAGVVVLPDLGSSVLTAATVLEDEPRPGVELVDAPFVEGAVAAAVTASTGAGLAEVVAAAEDARTFRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG9</accession>
    <name>A0A1E7MZG9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557788.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4396"/>
    <dbReference type="EnsemblBacteria" id="ARF80313">
        <property type="protein sequence ID" value="ARF80313"/>
        <property type="gene ID" value="B6264_16620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33845">
        <property type="protein sequence ID" value="OEV33845"/>
        <property type="gene ID" value="HS99_0037550"/>
    </dbReference>
    <dbReference type="OMA" id="ECRRAYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="582" mass="61942" checksum="257B5F29E5619853" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI0</accession>
    <name>A0A1E7MZI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polynucleotide kinase-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0037625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4520"/>
    <dbReference type="EnsemblBacteria" id="OEV33821">
        <property type="protein sequence ID" value="OEV33821"/>
        <property type="gene ID" value="HS99_0037625"/>
    </dbReference>
    <dbReference type="OMA" id="VCEEKHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024028">
        <property type="entry name" value="PNKP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032390">
        <property type="entry name" value="PNKP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032380">
        <property type="entry name" value="PNKP_ligase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16536">
        <property type="entry name" value="PNKP-ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16542">
        <property type="entry name" value="PNKP_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04075">
        <property type="entry name" value="bacter_Pnkp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="169"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP_ligase" evidence="3">
        <location>
            <begin position="453"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="PNKP-ligase_C" evidence="2">
        <location>
            <begin position="789"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="848" mass="92617" checksum="A079C80AB89420C1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN0</accession>
    <name>A0A1E7MZN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280931.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000811.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4942"/>
    <dbReference type="EnsemblBacteria" id="ARF80010">
        <property type="protein sequence ID" value="ARF80010"/>
        <property type="gene ID" value="B6264_14805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33673">
        <property type="protein sequence ID" value="OEV33673"/>
        <property type="gene ID" value="HS99_0038475"/>
    </dbReference>
    <dbReference type="OMA" id="DLMIPRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="441" mass="46488" checksum="7A518CA49BAC1F6A" modified="2017-01-18" version="1">MNETLGDAALVLVFILLGGLFNVAEISLISLREGQIRALEARGTRRSARAAHLAADPNRFLAAVQVGVTCMGFLSAAFGADTLAGKVAPLFVDAGLSRGMADAVALVGLTLVISYVSLVLGELTPKRIGLQRAESIAVGAAPVVDVMSAALRPVIWLLGHSTNLMVRLFGGDPAAGRGSMSSEELRGLVASNTELGSDERALIADVFAAGERQLREVMVPRTEVTFLDAERPLAAVRHQSETSPHSRYPVVEGSADAVVGFVHVRDLYGARGEQAVKVRDLARPVKLLPGTKRVLEAMGEMRREGHHLAIVVDEYGGTAGIVTLEDLVEEVIGEIRDEYDRPEAAPTRRLAGGGMELDGLLNLGDFEEETGVALPEGPYETVAGCLVASLGRLPRDGDHARVPVEGGGAVLLTVAKVEGRRIARVRVSAVTPEEPAGAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS7</accession>
    <name>A0A1E7MZS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737989.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2168"/>
    <dbReference type="EnsemblBacteria" id="OEV33947">
        <property type="protein sequence ID" value="OEV33947"/>
        <property type="gene ID" value="HS99_0010815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="15975" checksum="B11BD4410EAE0845" modified="2017-01-18" version="1">MTTEQLRPGSGSLAQNRSSHPSPYGGDRLLFLTEALRTFHDTGALAPSGPDLVDALVVSVTSRPNRPISVLEVGAGTGVVTRRLARVLRPGDRLHVVEANPRFAERLRDDPVLAARRPEVGLRLSVCRVEELPEAADGPGPDSQGAPGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU1</accession>
    <name>A0A1E7MZU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2166"/>
    <dbReference type="EnsemblBacteria" id="ARF77799">
        <property type="protein sequence ID" value="ARF77799"/>
        <property type="gene ID" value="B6264_01645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33945">
        <property type="protein sequence ID" value="OEV33945"/>
        <property type="gene ID" value="HS99_0010805"/>
    </dbReference>
    <dbReference type="OMA" id="MSNRVQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23341" checksum="AC526355CFF639AD" modified="2017-01-18" version="1">MIRTMVVDDDALVRLGLVDLLDQDPELTVVADAVDGLQAVELARGHRIDVALMDIRMPRLDGIAATRRLRQLPDAPRVIALTTFDLDEYVYQALAAGADGFLLKDTPPAEIARAVHVVASGQGMLHPAAARRLIDRYHRVGARRAVAARSRIAGLTPREGDVLRELADGLSNAEIAGVLGMRESTVKAHVSRILTALGVANRVQAALLARDAGLVGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N031</accession>
    <name>A0A1E7N031_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280118.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2283"/>
    <dbReference type="EnsemblBacteria" id="ARF77893">
        <property type="protein sequence ID" value="ARF77893"/>
        <property type="gene ID" value="B6264_02210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34035">
        <property type="protein sequence ID" value="OEV34035"/>
        <property type="gene ID" value="HS99_0011360"/>
    </dbReference>
    <dbReference type="OMA" id="QLWGPRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="33286" checksum="5E73526072336311" modified="2017-01-18" version="1">MSSAPPTSPWNVRRLPRADGSVVLVTGGNAGIGYFVAEQLAATGATVVLGSRNPAKAENAMASIRARVPGAQVRAVRLDVADLGSLRTVADALGVERLDAVVHNAGVALDDPPRQETGDGHELMFGTNHLGHFALTHWLMPLLSAAPAARVITMGSFAAKSERLDLDDLQSRRDYRPKRTYGRSKLAQMHFGLEFDRRLRAAGSTVASVVVHPGGALDSLTPSRPGVHTKTAAARLGAAPAALLLQGKHAGAWPAVRAVLDPAVRGGQLWGPRAFGLRGEPHREPVWANLADTTVAARLWDASRDLTGVDPAAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N061</accession>
    <name>A0A1E7N061_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77939">
        <property type="protein sequence ID" value="ARF77939"/>
        <property type="gene ID" value="B6264_02475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34080">
        <property type="protein sequence ID" value="OEV34080"/>
        <property type="gene ID" value="HS99_0011620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="25632" checksum="9D4570CA7788A4A3" modified="2017-01-18" version="1">MGMGGRRMVAVVAGGVLAGVLVGCSSGGSGDGKGAVGAGSSAGSGSPAASAVTSAAAAVPTGAGGSASAVASASPGGASGAGGSATPVPAVAAPSADLEGTLLDDKVVGQVLPDAKVMAGWDEEKRKVDTADHSVTCSASAPCTGKPLSGSVRFSSGDLVTRFLVETLPSRDAARNRLKETYASYPVGPFHKVDAPALGSESQVFVGPLSAGDGVSTVVRSGTVVASVTTEGGPVDLPAARRFAVMLVKRIEQAQAGKTPDAGLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D7</accession>
    <name>A0A1E7N0D7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1873"/>
    <dbReference type="EnsemblBacteria" id="OEV34149">
        <property type="protein sequence ID" value="OEV34149"/>
        <property type="gene ID" value="HS99_0010675"/>
    </dbReference>
    <dbReference type="OMA" id="VEYAGRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20839" checksum="9440706101948DE6" modified="2017-01-18" version="1">MDPADSVLALKILVAGGFGVGKTTLVGAVSEIRPLRTEERLTEAGREVDDLDGVERKTTTTVAMDFGRITIREGLALYLFGTPGQDRFWFLWDELAQGALGAVVLADTRRLTDCFPAVDFFEHRSIPFVVAVNRFAGTSEYGPEEVARALDLDPGTPVVLCDARQRASGKEVLISLVEHAGRVHAARLLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E0</accession>
    <name>A0A1E7N0E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283122.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1864"/>
    <dbReference type="EnsemblBacteria" id="ARF82549">
        <property type="protein sequence ID" value="ARF82549"/>
        <property type="gene ID" value="B6264_01470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34144">
        <property type="protein sequence ID" value="OEV34144"/>
        <property type="gene ID" value="HS99_0010630"/>
    </dbReference>
    <dbReference type="OMA" id="MYNKLMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28316" checksum="ECFEA556B30E46B0" modified="2017-01-18" version="1">MDKVAEILAEASAQAVEPRFRALAAGEVMEKAPGEVVTIADREAEAIITRRLHELLPVPVVGEEAVAADPSLADAIHDEPAVWLVDPVDGTSNFVAGRPDYAVMCSLVRTGRTVASWIWQPATATGYRAELGSGAWRDSERLTRPPAPADAGKLTGVLKSRFLDPVDRHRLEAGCSAFGEISPGRSAAGIEYPDVVEGRTDFIFYWRTLPWDHAPGSLLLAEAGGVAARLDGTPYQPEAPGCVDGLLVAADPDTWERTRGILLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N121</accession>
    <name>A0A1E7N121_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553539.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3926"/>
    <dbReference type="EnsemblBacteria" id="OEV34372">
        <property type="protein sequence ID" value="OEV34372"/>
        <property type="gene ID" value="HS99_0036240"/>
    </dbReference>
    <dbReference type="OMA" id="WNTDHTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="467" mass="49675" checksum="9AD2182A72D7047A" modified="2017-01-18" version="1">MADERVHAFTDDALGAHDAVALAALVRSGEVSPRELVAAAVARAGRIDGALLPVAHASYDRPRISREGIGGPLWGVPTYLKDNVDLRGLPTGMGSEAFRARPARRNARFTDQLLSTGLAVLGKTRLPEFGLNASTEFATAQPVRNPWKTSHSPGASSGGAAALVAAGVVPIAHANDGGGSIRIPAACCGLVGLKPTRGRLVTNAQGGKLPIDLVTDGVVTRSVRDTAAFFAAAERHHRNPKLPPLGLVEGPGERRLRIGLVVDSPTAKTDEATRRAVEETAARLEAMGHRVVPTTLPFGEEFSRDFLAYWGYIAWVIALTGRLVLDPGFRAGKLDGLTTGLRRSFQAEFRRTPGVLRRLRRTEAVYAGIFREHDAILSPVLAHTAPPIGHLSPNVAFDELVDRLLRYVAFTPVNNVTGGPGISLPAGAAPSGLPIGVHLSAAHGQERVLLELAYALEADRPWRRIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N141</accession>
    <name>A0A1E7N141_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283302.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3935"/>
    <dbReference type="EnsemblBacteria" id="OEV34381">
        <property type="protein sequence ID" value="OEV34381"/>
        <property type="gene ID" value="HS99_0036285"/>
    </dbReference>
    <dbReference type="OMA" id="NEEFHAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="25645" checksum="EA7568C9B2B31D35" modified="2017-01-18" version="1">MTRERLAVVSGGGTGIGRAIAARLAGDGYRVAVLGRRAAVLEEARARIERDAGPGAVVPVAGDLTDPAVVEQVAARVGELGPVDVLVNNAGAIITPPEDAGLAALAASWRRDLDTNLLTAVLLTTALQGALRRPGGRLVVISSAAAQRGGAGPHSAGSYAAAKAALHGWAFGLARQLGPDGITVNVLAPGYVVDTEIFGADWNEEFHARKVADTLVGRAGTPADVAEAVAYVASPAAGYLTGQVIGLNGGAVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W0</accession>
    <name>A0A1E7N1W0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS66 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000115_gene4545"/>
    <dbReference type="EnsemblBacteria" id="OEV34679">
        <property type="protein sequence ID" value="OEV34679"/>
        <property type="gene ID" value="HS99_0009320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21445" checksum="1E056D2086BC1017" modified="2017-01-18" version="1">MTEHRIEHRRCACGQVTGASAPQGAGAPAQYGPGLKSLAVYLLTRQHLPYQRCGELLADVLGADVATATLLGWAGQAAEAVAPHTEAVRRQLTDCEVVGFDETGTRIAGRTCWVHTACTKSLTLYLLHAKRGMEAFEAMGVLPHFGGIAVHDGWKPYKTYAGAVHALCNAHHLCLTTKPVTGMLGRLLAHASRRTRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2C4</accession>
    <name>A0A1E7N2C4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7631"/>
    <dbReference type="EnsemblBacteria" id="ARF81808">
        <property type="protein sequence ID" value="ARF81808"/>
        <property type="gene ID" value="B6264_25520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34832">
        <property type="protein sequence ID" value="OEV34832"/>
        <property type="gene ID" value="HS99_0010205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9365" checksum="D3B5D0776A29A299" modified="2017-01-18" version="1">MPDFHPKHDHLIVKPIGGSTPQDPARRKGEVVAVGPGRQLESGKPHPVDVKVGEKILFNSFAGSDIEVEGQAYVELPEDEVLALSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D1</accession>
    <name>A0A1E7N2D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34603">
        <property type="protein sequence ID" value="OEV34603"/>
        <property type="gene ID" value="HS99_0008870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="27974" checksum="AE787D88CA5A1EE3" modified="2017-01-18" version="1">MPHHGYEAVQALRDPAQERYFSQGTARVTSPTNGMSASEIIAALREKLDGRATTIVRYPDTVEHVRRLSDEIAGLPADDGSNGVGKGGKTGPGDHRAITEALDRLMSETGPLGRDPEVLERVRRLDRAVTAAADAVPSTEELSEIISFGDSPQAADCCGDAGERGEVLALAFVAAVEAAETVEPGDGALDHPSVSAQALGGVDAPAGDAGRDLASSQVGADESVVVGLVAVEFAWPASPGAAARADGRDGIGQRDQGLAVVDVGAGYRERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R2</accession>
    <name>A0A1E7N2R2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="4" type="ORF">HS99_0034760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290414.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4571"/>
    <dbReference type="EnsemblBacteria" id="ARF78523">
        <property type="protein sequence ID" value="ARF78523"/>
        <property type="gene ID" value="B6264_06000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34974">
        <property type="protein sequence ID" value="OEV34974"/>
        <property type="gene ID" value="HS99_0034760"/>
    </dbReference>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20501" checksum="EDA34B61F1B41313" modified="2017-01-18" version="1">MIEETLLEAEEKMEKAVVVAKDDLAAIRTGRAHPAMFAKIVAEYYGAVTPINQLASFSVPEPRMAVVSPFDKTALKAIEQAIRDSDLGVNPSNDGSIIRVVLPELTEERRREFIKIARGKGEDAKVSIRAVRRKAKDAIDKLVKDGEVGEDDGRRAEKELDDTTAKYVAMVDELLKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U7</accession>
    <name>A0A1E7N2U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4559"/>
    <dbReference type="EnsemblBacteria" id="OEV35000">
        <property type="protein sequence ID" value="OEV35000"/>
        <property type="gene ID" value="HS99_0034820"/>
    </dbReference>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="44145" checksum="7E393E33B8E46573" modified="2017-01-18" version="1">MPEPVRRAWERSLTSGRAAVGRRTLLRAAALTAGAGTLAACGIPAAPRATGDSTANAAKDLSDSEKEVDFSNWPLYVDTDEKDKEKHGTLDAFTAATGIKVKYNEDVNDNVEFFGKVKPQLAAGEDTGRDLVVLTDWMAARLIRLGWAQKLNPANVTTAITNVEARFRAPDWDPGRLYTYPWAGIQTVVAYNRKATRGKEVTSVSQLLDDPDLKGRVTFLSEMRDSIGMVLLDMGKDPAKFTADDYDAAIARLQKAVDGKQIRRFTGNDYGQELSSGDIAACVAWGGDLIQLRADNPDIEFAIPEKGYLASTDNMLVPAKARHKTNAEKLIDFYYQPKIAAQLVAGIGFVSAVTGMKDELAALAPDSAANPLVVPTPEMAAKAHVFRTLTEGEESEFEQKFSKLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N392</accession>
    <name>A0A1E7N392_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554117.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000639.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5879"/>
    <dbReference type="EnsemblBacteria" id="ARF82050">
        <property type="protein sequence ID" value="ARF82050"/>
        <property type="gene ID" value="B6264_27025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34923">
        <property type="protein sequence ID" value="OEV34923"/>
        <property type="gene ID" value="HS99_0035010"/>
    </dbReference>
    <dbReference type="OMA" id="YEWSWTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26859" checksum="2DA53FB41A0A3CEE" modified="2017-01-18" version="1">MDRQRISRLAHAHHPIAAPLSDGSVARLLDRALAGQEAGRALDLGCGEGAWLLRALAARPAWRAVGVDLDAAALTRARETATALGVERRIGLHHRDARDFTAPEPFDLVLCVGATHAFDGLLPTLAAARELLAPGGRLLVGEGYWEREPSRAALDGLGAAPEDFADLATTTDRVLADGWTPVYGHVSTAREWDDYEFSWTGSLAGWALDHPDHPDAAAAREAADRHRADWLHGYRATLGFVTYLLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3N5</accession>
    <name>A0A1E7N3N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282778.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5295"/>
    <dbReference type="EnsemblBacteria" id="ARF80708">
        <property type="protein sequence ID" value="ARF80708"/>
        <property type="gene ID" value="B6264_18950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35282">
        <property type="protein sequence ID" value="OEV35282"/>
        <property type="gene ID" value="HS99_0033010"/>
    </dbReference>
    <dbReference type="OMA" id="LFCAHPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="48185" checksum="FF09FD0CF926E2E5" modified="2017-01-18" version="1">MSVSLDLHAPLAVLGHDVQVPLASGEKVGYAALDYAASAPALQRVWDDVAAYAPYYGSVHRGAGYLSQLSTDLFEQSRRTVAEFLDLREGDQVVFTRATTDSLNLLATAVPAGTRVFAFETEHHASLLPWAHAGLEVGYLRAPRSRAEAVAALEAALAAAPEGPKLLCVTGASNVTGELWPVAELTATAHRYGARVVLDAAQLAPHHRVSVRELDVDWIAFSGHKLYAPFGAGVLAGRSDWLDAAEPYLAGGGATRTVAREQDGSVAVQWHTGPARHEAGSPNVIGAYAIASACRALTEAGFDVLEARERRLVERLTAGLAEIPQVKVLNLFGEGSARVGVLSFVVRGWNSSHFSAALSAEYGIGVRDGLFCAHPLVRTLLGDEEVAPSECGAPEPSLPGERSLNAIRVSFGAGTPDEHVERFLTAVRELVTDGAAWNYRNEGGRCVADSRRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N410</accession>
    <name>A0A1E7N410_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1397"/>
    <dbReference type="EnsemblBacteria" id="ARF79252">
        <property type="protein sequence ID" value="ARF79252"/>
        <property type="gene ID" value="B6264_10285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35193">
        <property type="protein sequence ID" value="OEV35193"/>
        <property type="gene ID" value="HS99_0033255"/>
    </dbReference>
    <dbReference type="OMA" id="EVAAFWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="758" mass="83332" checksum="BAE785406E886160" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4A5</accession>
    <name>A0A1E7N4A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366664.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5516"/>
    <dbReference type="EnsemblBacteria" id="ARF79391">
        <property type="protein sequence ID" value="ARF79391"/>
        <property type="gene ID" value="B6264_11080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35502">
        <property type="protein sequence ID" value="OEV35502"/>
        <property type="gene ID" value="HS99_0031890"/>
    </dbReference>
    <dbReference type="OMA" id="WWNRTTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="18960" checksum="B6538E8759F4B27A" modified="2017-01-18" version="1">MEHDEQVALLSTPPDARDVSAELAAPPRRKLPWLSLVLAGGVIATGAFAGGVWYQQGQGTSSGKSSSPRAASAGAPATGGGYGQGAGGRRGGQGQGQGQGQGGFTRGTVKAVDGSTVYLTDANGNTVKVTTGDSTKVQLNKEGKVADLQPGQSVTVVGTPDANGGYNASQLVEGSAGGGFGGGGFGGGNRNPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R9</accession>
    <name>A0A1E7N4R9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0007220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551124.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene882"/>
    <dbReference type="EnsemblBacteria" id="ARF80889">
        <property type="protein sequence ID" value="ARF80889"/>
        <property type="gene ID" value="B6264_19995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35689">
        <property type="protein sequence ID" value="OEV35689"/>
        <property type="gene ID" value="HS99_0007220"/>
    </dbReference>
    <dbReference type="OMA" id="MGMTHGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="574" mass="63799" checksum="2A6859C1829722C0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N523</accession>
    <name>A0A1E7N523_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene746"/>
    <dbReference type="EnsemblBacteria" id="OEV35790">
        <property type="protein sequence ID" value="OEV35790"/>
        <property type="gene ID" value="HS99_0007915"/>
    </dbReference>
    <dbReference type="OMA" id="EMAAWRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="17584" checksum="7DC6CBD5248AEDF5" modified="2017-01-18" version="1">MSALNEPRWLDRDEMAAWRGFVVASNLLNRRLERQLKEDSGLSHQQYEILVHLSAAPGDSLRMTELADKLVTSKSGLTYQVTQLERMGLVARRSCPSDVRGVIAELTGQGREMIRRAAPGHVALVRELLIDVLTREQLAVLAESLGAVSARLRQDDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N526</accession>
    <name>A0A1E7N526_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0007965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene736"/>
    <dbReference type="EnsemblBacteria" id="OEV35797">
        <property type="protein sequence ID" value="OEV35797"/>
        <property type="gene ID" value="HS99_0007965"/>
    </dbReference>
    <dbReference type="OMA" id="HGRLCRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20564" checksum="9D159BF6B8EB0BB3" modified="2017-01-18" version="1">MVTDEHPVGGSAAHGAGAADEELMRALYREHAGPLFAFVLHLVAGDRQRAEDVVQETLVRAWRNIHRLDPQVDSLRPWLVTVARRIVIDDHRSARARPHEVDAEALKQLPAEDDIERALRMMTVADALADLSPAHREVIVETYLRGRTAKEAATELGIPAGTVRSRVFYALRSLRLALEERGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N584</accession>
    <name>A0A1E7N584_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556837.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81050">
        <property type="protein sequence ID" value="ARF81050"/>
        <property type="gene ID" value="B6264_20990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35839">
        <property type="protein sequence ID" value="OEV35839"/>
        <property type="gene ID" value="HS99_0008210"/>
    </dbReference>
    <dbReference type="OMA" id="HGHTTYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="173" mass="18686" checksum="58B3A26512C2CCDE" modified="2017-01-18" version="1">MNRRLWILAGAGAAALAGAALLAADRAGRRLPVEHVTEGGLELAQPPGAVWDVLTDIDLYPAWRPGLTHVERLPSGAGGRLRWREYDRHGHTTYEVVASEAPHRLVTGIADPDLPYGGTWTYQLTPAGPGCSLTVTERGEVRRPLSRAVSHYLTGEDATVHRYLGALAHRMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D7</accession>
    <name>A0A1E7N5D7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553614.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7285"/>
    <dbReference type="EnsemblBacteria" id="OEV35905">
        <property type="protein sequence ID" value="OEV35905"/>
        <property type="gene ID" value="HS99_0008585"/>
    </dbReference>
    <dbReference type="OMA" id="LIWRQHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="34502" checksum="D2FDAABEBA627BD1" modified="2017-01-18" version="1">MSSTTLAPPRSAVLRAAGLRHRPALLTLLAVMGVVSLALLLHGWYLHAGLDRTGAGSCDPATDACRVKFKQFLHQYADSVPMLTSVSYVLGGTFGAFLGGPLLAREFEHGTVRFAWTQGAGRSRWTAGGLVVGGAVLAGVSVPFGLLLRWWSVPSVMASGSFSPEAFVQLPPVLVGRVLVAFGVAALAGAVLRRTVIAVGLGLAVSVALPFLAYAVRSHYMAPVEEPVHTLAPLALDDRWVLSVWFSDPAGNRISESDFYNLGRDYANLQSLVSDGGYTMHQVYQPADRLWPFQWIEFGWTTLLAVALCAAAVWWVRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D9</accession>
    <name>A0A1E7N5D9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="2" type="ORF">HS99_0008645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000381.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7297"/>
    <dbReference type="EnsemblBacteria" id="ARF81128">
        <property type="protein sequence ID" value="ARF81128"/>
        <property type="gene ID" value="B6264_21420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35916">
        <property type="protein sequence ID" value="OEV35916"/>
        <property type="gene ID" value="HS99_0008645"/>
    </dbReference>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="34834" checksum="440B0934508FB2F5" modified="2017-01-18" version="1">MALQVAVAGASGYAGGEVLRLLLGHPEVEIGALTGGSNAGSRLGALQPHLVPLADRVLQPTTPEVLADHDVVFLALPHGQSAAVAEALGQNVLVVDCGADFRLRAAADWEQFYGTAHAGTWPYGLPELPGHRAVLKGTNRIAVPGCYPTAVSLALFPAYASRLAEPEAVVVAASGTSGAGKAAKPHLLGSEVMGSVSPYGVGGVHRHTPEMVQNLTPVAGEPVTVSFTPTLVPMPRGILATCSAKAKPGVSAESLRAAYAEAYEDEPFVHLLPEGQWPQTSSVYGANTALVQVALDAAAGRIIAISAIDNLVKGTAGGAVQSMNIALGLPEELGLPLNGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N618</accession>
    <name>A0A1E7N618_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280973.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80039">
        <property type="protein sequence ID" value="ARF80039"/>
        <property type="gene ID" value="B6264_14955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36094">
        <property type="protein sequence ID" value="OEV36094"/>
        <property type="gene ID" value="HS99_0030975"/>
    </dbReference>
    <dbReference type="OMA" id="TQQRTGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="10731" checksum="9E66C8BC77348A86" modified="2017-01-18" version="1">MKQALKAAGTAALGIAIAAVGAGTASAAGQATGGLGLPTGAVTNPAVTGAVTDTAAKLPGGDKVAGTLGTLAPTAGQSVPAGATPIAGVTQQRTGIPSIPGLDKTPVGGLTGVLPGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C5</accession>
    <name>A0A1E7N6C5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2667"/>
    <dbReference type="EnsemblBacteria" id="OEV36257">
        <property type="protein sequence ID" value="OEV36257"/>
        <property type="gene ID" value="HS99_0030055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="7607" checksum="613BAE690154DF0C" modified="2017-01-18" version="1">MPSTRLLFTVRAADCHACAHDPRAAVELLGPALESAPAAALPALVGHELRGLRGRLAPYEPQAARRLAELAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J3</accession>
    <name>A0A1E7N6J3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835469.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2607"/>
    <dbReference type="EnsemblBacteria" id="OEV36310">
        <property type="protein sequence ID" value="OEV36310"/>
        <property type="gene ID" value="HS99_0030350"/>
    </dbReference>
    <dbReference type="OMA" id="FERERHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1708"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1464"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1635"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1779"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1838" mass="188232" checksum="BA27B9C18E85F351" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M7</accession>
    <name>A0A1E7N6M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553099.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000715.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4902"/>
    <dbReference type="EnsemblBacteria" id="ARF82369">
        <property type="protein sequence ID" value="ARF82369"/>
        <property type="gene ID" value="B6264_28960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36342">
        <property type="protein sequence ID" value="OEV36342"/>
        <property type="gene ID" value="HS99_0029700"/>
    </dbReference>
    <dbReference type="OMA" id="IEGHVQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33645" checksum="A2283F6EE75D257B" modified="2017-01-18" version="1">MTKAIILSGLRKTFGRTTALDGLDLTVETGEVHGFLGPNGAGKSTTIRVLLGLLRADGGSARLLGKDPWSDAVELHRRLAYVPGDVELWPNLTGGEAIDLLSRLRGRLDRHRRDELLERFDLDPTKKGRSYSKGNRQKVAIVAALASDAELLLLDEPTSGLDPLMEVVFQDVVRQAKEQGRTVLLSSHILDEVEKLGDRVSIIRQGRVVQSGTLGELRHLTRTTVEAETSRPVTGLDALSGVHALRTDGLRVRFAVDGARLDAAVRTLSEAGLRSLVSHPPTLEELMLRHYGDELATNGHRSEDEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N737</accession>
    <name>A0A1E7N737_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288998.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1469"/>
    <dbReference type="EnsemblBacteria" id="ARF79187">
        <property type="protein sequence ID" value="ARF79187"/>
        <property type="gene ID" value="B6264_09870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36511">
        <property type="protein sequence ID" value="OEV36511"/>
        <property type="gene ID" value="HS99_0028710"/>
    </dbReference>
    <dbReference type="OMA" id="SPMEIRN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="26502" checksum="E4517F2C9CB9BAC4" modified="2017-01-18" version="1">MSSLLLLTNALQPSAEVLPALGLLLHNVRVAPAEGSALMDTPSADVILVDGRRDLPQIRSLCQLLRSTGIGCPLILVVTEGGLAAVTAEWGIDDVLLDTAGPAEVEARLRLALGRLQVAVDDSPMEIRNGDLSVDEATYSAKLKGRALDLTFKEFELLKYLAQHPGRVFTRAQLLQEVWGYDYFGGTRTVDVHVRRLRAKLGVENEQLIGTVRNVGYRFVVPEKAEKSERPDLSQRPSAPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N783</accession>
    <name>A0A1E7N783_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper homeostasis protein CutC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289671.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7889"/>
    <dbReference type="EnsemblBacteria" id="ARF79139">
        <property type="protein sequence ID" value="ARF79139"/>
        <property type="gene ID" value="B6264_09605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36557">
        <property type="protein sequence ID" value="OEV36557"/>
        <property type="gene ID" value="HS99_0028980"/>
    </dbReference>
    <dbReference type="OMA" id="CRWTFHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="23768" checksum="447A5703F12D56F9" modified="2017-01-18" version="1">MSRPIFEVIALTPQDAQAAESGGADRLELVTDMAADGLTPSVEDFARIRAAVGIPLRVMLRIRDGFAPGDLDELCARAAALRAEGAEEFVLGFLDAEGAVDLAATTTVAEAIAGCCWTFHRAIDHGADRAALRAAVGALPGLDTFLTSGAAAGVDAGREVLAAELARTGEPGYTQRILIGGGLRAEHLKELRADGFDAFHVGGAVRVDGWHTPVDAARVAEWRALIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K3</accession>
    <name>A0A1E7N7K3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278879.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2506"/>
    <dbReference type="EnsemblBacteria" id="ARF81498">
        <property type="protein sequence ID" value="ARF81498"/>
        <property type="gene ID" value="B6264_23590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36670">
        <property type="protein sequence ID" value="OEV36670"/>
        <property type="gene ID" value="HS99_0028300"/>
    </dbReference>
    <dbReference type="OMA" id="AGFRWHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="39527" checksum="E7CB009D08FE6499" modified="2017-01-18" version="1">MDLPVMPPVAPMLAKSVAKIPPGMQYEAKWDGFRTIVFRDGDEVELGSRTGKPLTRYFPELVEAFRRELPPRCVLDGEVVIARDGRLRFEELLERIHPAASRVRLLAERTPASFVAFDLLALGDDPLVDEPLSVRRPALEAALRGAADPVFTAPASTDREVAQSWFAEFEGAGLDGVVAKPLDQPYRPGERTMYKIKHERTADCVVAGYREHKSGPVVGSLLLGIYDEQGKLQHVGVCAAFPMARRRQLVEELAPLRMDDLAQHPWGAWAEEAAHAEGRLPGAVSRWTGGKDLSWIALRPERVIEVAYDHMEGSRFRHTAQFRRWRPDRTPESCTYEQLEEPVSYDLGQVLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8G0</accession>
    <name>A0A1E7N8G0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene146"/>
    <dbReference type="EnsemblBacteria" id="ARF81741">
        <property type="protein sequence ID" value="ARF81741"/>
        <property type="gene ID" value="B6264_25130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36985">
        <property type="protein sequence ID" value="OEV36985"/>
        <property type="gene ID" value="HS99_0003885"/>
    </dbReference>
    <dbReference type="OMA" id="TFTTRSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="641" mass="70287" checksum="46F6D29DF36E4EA5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8J1</accession>
    <name>A0A1E7N8J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0004080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558447.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000119.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000145_gene2718"/>
    <dbReference type="EnsemblBacteria" id="ARF81709">
        <property type="protein sequence ID" value="ARF81709"/>
        <property type="gene ID" value="B6264_24920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37016">
        <property type="protein sequence ID" value="OEV37016"/>
        <property type="gene ID" value="HS99_0004080"/>
    </dbReference>
    <dbReference type="OMA" id="APEAWIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="19008" checksum="00F1F27189D226B4" modified="2017-01-18" version="1">MTPQEFDAFYAASFSRLTGQLYVITGNWSEAQDVVQEAFIRAWGRRRTFDPGNAPEAWIRTTARRLAHSRWRRLARGLLLAGRHHRQEPFTVEPPTEEHLILVTALRDLPEAQRSALVLHHMCDLSVEQVAAETGASVSAVKSRLARGRTALAAILADQAPTSEEGKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T9</accession>
    <name>A0A1E7N8T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6667"/>
    <dbReference type="EnsemblBacteria" id="ARF81614">
        <property type="protein sequence ID" value="ARF81614"/>
        <property type="gene ID" value="B6264_24320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37116">
        <property type="protein sequence ID" value="OEV37116"/>
        <property type="gene ID" value="HS99_0004670"/>
    </dbReference>
    <dbReference type="OMA" id="AKCRTAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="21025" checksum="B5306BBD7F261CEA" modified="2017-01-18" version="1">MHARKLAFAALAVAAALSLTACQNDDTDTAQGTSTAGPTASTGTAPVGGPASNAPATSKPGKPGTAPTTAPAGSTGAGKTAKCRTADLTITAADHTITGDPTNTVVVELKNHSGKDCTLSGYAGVDLTTPSGTLSAKRSGEPVVTGVVANGKSTYFGISYPANNTGGSGLRITGLVVTPPDETQSVTLPWPGAGSLPAADDSAPVKIGPIGSAGQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U0</accession>
    <name>A0A1E7N8U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387213.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6684"/>
    <dbReference type="EnsemblBacteria" id="ARF81626">
        <property type="protein sequence ID" value="ARF81626"/>
        <property type="gene ID" value="B6264_24400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37102">
        <property type="protein sequence ID" value="OEV37102"/>
        <property type="gene ID" value="HS99_0004590"/>
    </dbReference>
    <dbReference type="OMA" id="KYYRRTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="18207" checksum="30A39EF360480D2B" modified="2017-01-18" version="1">MSHQRDADVQRVSTPVQHTALAHPVRQRLLFALSARPSTISRLAARLGVNKGSVSHHLKVLCEAGLVRDAGTRTVRGGTEKYYRRTAERLLVDEPQPEGTAALFGAVAQELDRSPSDHLLTLRHVRLSPAKAARLAEALAALVDETEEDAEGEPVHGLLVTLYQQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N909</accession>
    <name>A0A1E7N909_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556636.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6208"/>
    <dbReference type="EnsemblBacteria" id="ARF81563">
        <property type="protein sequence ID" value="ARF81563"/>
        <property type="gene ID" value="B6264_24010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37172">
        <property type="protein sequence ID" value="OEV37172"/>
        <property type="gene ID" value="HS99_0004980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="6790" checksum="97C11AF71F084F19" modified="2017-01-18" version="1">MTSLLHGRDLVRAFDHAAPAYDLLTALDPGHLGALRRSARRLRLADGGAGAAAAHPRSAQPEAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N997</accession>
    <name>A0A1E7N997_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0005580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1299"/>
    <dbReference type="EnsemblBacteria" id="OEV37267">
        <property type="protein sequence ID" value="OEV37267"/>
        <property type="gene ID" value="HS99_0005580"/>
    </dbReference>
    <dbReference type="OMA" id="ERYLEYP"/>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="495"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1564"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1640"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1660" mass="178200" checksum="72A5F0DDFF02BB44" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H0</accession>
    <name>A0A1E7N9H0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556493.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5457"/>
    <dbReference type="EnsemblBacteria" id="OEV37336">
        <property type="protein sequence ID" value="OEV37336"/>
        <property type="gene ID" value="HS99_0006005"/>
    </dbReference>
    <dbReference type="OMA" id="CANDYST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="17274" checksum="FA43DA4F08EA4BE8" modified="2017-01-18" version="1">MARTWADSWEAEWAGEGCAKCAQGRPDEDEWGVRWYADSFADAYLLKRPASPGYSVVVFRGRHVPDPALFTDAEFTGYWSAVRTVGAAIHRVYAPAQINYQCMNNSVAHVHTHVLPRYLDDSGPRTMLPDQAFAGAHSLAPAELLAQLARLKAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H5</accession>
    <name>A0A1E7N9H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37294">
        <property type="protein sequence ID" value="OEV37294"/>
        <property type="gene ID" value="HS99_0005740"/>
    </dbReference>
    <dbReference type="OMA" id="ILQGMHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20217" checksum="33CCFE771C7937B1" modified="2017-01-18" version="1">MRALAWPGGEAGCVSIMSEDPVSPDQVYAALVALRREPILDPELWPDGPQQDDLRRLLGVLLAVVELEITAATRLGSDQDTDVAEVLPGWTDQVGATPGLFANVLANRLQRTVQLMGLDEVEEGGETSPGRMASSMAVVAAADTLDADLNFQSGDIDGVRQALGRAEASVIEIQQSMHDLRVAIGDAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V4</accession>
    <name>A0A1E7N9V4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385751.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7937"/>
    <dbReference type="EnsemblBacteria" id="ARF79098">
        <property type="protein sequence ID" value="ARF79098"/>
        <property type="gene ID" value="B6264_09370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37475">
        <property type="protein sequence ID" value="OEV37475"/>
        <property type="gene ID" value="HS99_0025985"/>
    </dbReference>
    <dbReference type="OMA" id="MVTIDCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14889" checksum="027F8F8B5774830F" modified="2017-01-18" version="1">MSDVVAEQPPQSPQGDTGFARLAMVTIDCADPVALASFYGELLGWETRHVDEHFAILDNPEGGSPLGFGRVTGYRPEPWTEPDGSKHFHLDFYVDDLEESTAKALALGATEPDYQHGRTLKVLIDPAGHPFGLAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA02</accession>
    <name>A0A1E7NA02_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481032.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1241"/>
    <dbReference type="EnsemblBacteria" id="OEV37313">
        <property type="protein sequence ID" value="OEV37313"/>
        <property type="gene ID" value="HS99_0005860"/>
    </dbReference>
    <dbReference type="OMA" id="YCSRRCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="20058" checksum="BA77E1BB2020EDE9" modified="2017-01-18" version="1">MTQDLNGRNPRGLYFLTELANTVRDHPEATTADLQAVLERHGGPALQLTDTDAQELRQATTHLIAILTTRDPDNAAQAINTLLDRYPARPRLVKLPGRPWSMHTQTPPTADLTHWLLSTCALALGIWLSERQTCAWGQCAAPGCNRFYIDTGRRTPQRFCTPRCATRVRVAAHRAHQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM4</accession>
    <name>A0A1E7NAM4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280835.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1640"/>
    <dbReference type="EnsemblBacteria" id="ARF82834">
        <property type="protein sequence ID" value="ARF82834"/>
        <property type="gene ID" value="B6264_14560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37747">
        <property type="protein sequence ID" value="OEV37747"/>
        <property type="gene ID" value="HS99_0025770"/>
    </dbReference>
    <dbReference type="OMA" id="ADGDAMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="18689" checksum="F7D8940393A39DC7" modified="2017-01-18" version="1">MGPGVVVTGLTLGALAVVSLLAFQANGAQDRAGAARPTVASTSTGPAASATPSASATPTVPPLPASSGSGTRVVYSAGNHFVWLVDPKKNPQVAAAFPVTPGSVEPAPGSYSVYSRTAAGTGTDGRKIEHVVRFAQQAGVVFGFGAALDDTTPTADPKAKTGGIRSSRADGQLLWDFASNGTKVVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN1</accession>
    <name>A0A1E7NAN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cholesterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0025875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553122.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4915"/>
    <dbReference type="EnsemblBacteria" id="ARF79987">
        <property type="protein sequence ID" value="ARF79987"/>
        <property type="gene ID" value="B6264_14665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37728">
        <property type="protein sequence ID" value="OEV37728"/>
        <property type="gene ID" value="HS99_0025875"/>
    </dbReference>
    <dbReference type="OMA" id="DHTHIEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="601" mass="64432" checksum="E8B5B869C1E47E06" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAP4</accession>
    <name>A0A1E7NAP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387049.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000641.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3455"/>
    <dbReference type="EnsemblBacteria" id="ARF78097">
        <property type="protein sequence ID" value="ARF78097"/>
        <property type="gene ID" value="B6264_03450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37767">
        <property type="protein sequence ID" value="OEV37767"/>
        <property type="gene ID" value="HS99_0024550"/>
    </dbReference>
    <dbReference type="OMA" id="DGVPDIW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1184" mass="124711" checksum="D667E0F00EC6FE21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV0</accession>
    <name>A0A1E7NAV0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Melibiase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0024865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3734"/>
    <dbReference type="EnsemblBacteria" id="OEV37822">
        <property type="protein sequence ID" value="OEV37822"/>
        <property type="gene ID" value="HS99_0024865"/>
    </dbReference>
    <dbReference type="OMA" id="NRTANDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015925">
        <property type="term" value="F:galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="5">
        <location>
            <begin position="130"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="27313" checksum="13064DEBDBBE2DF3" modified="2017-01-18" version="1">MASPLILSTDIPNLSAASLATLSNTDIIAIDQDPLGKQAGIVSRNGTVDVLSRPLANGDRAVALLNRGTGTITAGTTLDAVGFQGGGCSAGVKDLWTGTRFSSTGTISTSIPAHGTAIFRVTPGAGCVGQQPTGQIAGIGGKCLDDAYAGTDPNNPVTLYSCHGGANQRWTMPGDGTVRTLGACLDAAYRSNDSRHVGYWAVLNPCDGRASEQWAYQRNGYLQNTGLHLCVDDYASDTTDATPIIVDGCGASEANQANQIWVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB11</accession>
    <name>A0A1E7NB11_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopeptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552137.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2144"/>
    <dbReference type="EnsemblBacteria" id="ARF79431">
        <property type="protein sequence ID" value="ARF79431"/>
        <property type="gene ID" value="B6264_11330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37882">
        <property type="protein sequence ID" value="OEV37882"/>
        <property type="gene ID" value="HS99_0023665"/>
    </dbReference>
    <dbReference type="OMA" id="FKSEVQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="30711" checksum="0F8F5BC3AC891886" modified="2017-01-18" version="1">MGMLKKFEQRLEGLVNGTFAKVFKSEVQPVEIAGALQRECDNNASIWNRDRTVVPNDFIVELSPHDHERLSPYSGQLGAELAGMVREYAEAQRYSFMGPLQVNLEKADDLDTGLYRVRSRTLASEEPQQYSPPQAPQQQSGYDRQPAAPAPGAPWQQGGAGQYNAPPPPAMPPGPPAGGNVRNFPGAGHGASVRRWIEVNGARHQITGAACVLGRSTEADVRIDDPGVSRKHAEIRPGTPSMVLDLGSTNGIVVDGQHTQRATLRDGSRIVVGSTTIVYRQVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK1</accession>
    <name>A0A1E7NBK1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830829.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000841.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3029"/>
    <dbReference type="EnsemblBacteria" id="ARF79719">
        <property type="protein sequence ID" value="ARF79719"/>
        <property type="gene ID" value="B6264_13125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38069">
        <property type="protein sequence ID" value="OEV38069"/>
        <property type="gene ID" value="HS99_0022975"/>
    </dbReference>
    <dbReference type="OMA" id="VRYEPMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="35584" checksum="722775BC5CD32C86" modified="2017-01-18" version="1">MPRDLHPRLLRGFVATAETLHFGRAAERLYVAQQALSRDVRTLEGLLGDTLFVRTTRSVELTPAGQRLLPRARRLLALHDEILAEAGTGAGAAARPLLLDLNSDVTGPDLTADRVLQRARAAWPEGELLARFHGGLAAAAAELLAHRLDASFGRFAGLSAPVRGQLAQLPVRLERISVMMADTHPLARRPALRPAELAGHPVDICAGNPATTEWADLGARLLREHGLAAAEPYVPPVGLDETARYLARHGDPMLTTVGGPKIPGSVNVPLVEPVPLCLVSLVHRPGERHPGLRALAAAASELGTAESWLSRPAGSWLPAADAELVAAAQNTAPASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW8</accession>
    <name>A0A1E7NBW8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="13" type="ORF">HS99_0023370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7148"/>
    <dbReference type="EnsemblBacteria" id="OEV38191">
        <property type="protein sequence ID" value="OEV38191"/>
        <property type="gene ID" value="HS99_0023370"/>
    </dbReference>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="64"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV38191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="31329" checksum="BA1A44FD31B95E13" modified="2017-01-18" version="1">MKATAKPTAKAAAKPPVKPRKPESHLAMVRRARRINRELAELYPYAHPELDFENPFQLLVATVLSAQTTDLRVNQTTPALFAKYPTPEDMAAANPEELEEVIRPTGFFRNKAKALIGLSTALRDEFGGEVPGRLADLVTLPGVGRKTANVVLGNAFGVPGITVDTHFGRLARRFGWTTEEDPVKVELAVAEIFPKSEWTMLSHRVVFHGRRICHSQKPACGACPIAPLCPAYGEGELDPEKARKLLKYEMGGQPGQRLKPPSDFPGEAAARADAAAHQGRVADLGVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC92</accession>
    <name>A0A1E7NC92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80180">
        <property type="protein sequence ID" value="ARF80180"/>
        <property type="gene ID" value="B6264_15800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38302">
        <property type="protein sequence ID" value="OEV38302"/>
        <property type="gene ID" value="HS99_0022470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8001" checksum="90250C330C865D0D" modified="2017-01-18" version="1">MMLAARVSMEAWKESLVVPSQLVAASVLTLVRVLRISLRVVAALRHGSPAAITAPGSSACAILRRSAWLYLVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC7</accession>
    <name>A0A1E7NCC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4169"/>
    <dbReference type="EnsemblBacteria" id="OEV38356">
        <property type="protein sequence ID" value="OEV38356"/>
        <property type="gene ID" value="HS99_0022505"/>
    </dbReference>
    <dbReference type="OMA" id="TARTMWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="46660" checksum="4E5778A5D67306C1" modified="2017-01-18" version="1">MREAPRRPLLVASSLALLSLVVYAVVRHFVHTSMVDMIVYRAEGAAVANGNDLYALRVTEWNLPATYPPFAAMLFVPTTWFPIAFLRVAITLGNLGLLALMAHLSFKLVGWPRRELRPVGVVLITGLGVWLEPVFTTLRYGQINLALGCLILWDLTRSDGRRSKGVAIGIAAGIKLTPGLFAVYLLITGRVRAAFTAGLTFLGTFLIGTLLLPDATWGFWTKYLYDSSRVGKTEIVDNQSLRGAFARLLHTPDPGVIATLGVGLVAVAGLAVAAWAARSGRWLPRSEAWGVCVAAVTAVLISPISWTHHWVWCVPMLVLLAAEASVEHARPAAVRRLRWRAFFWATLLAFLSFAMWAAKPLGAAVLHMSPLRQLPTSIYPWVGLCFLLAAVVRITARRRSAGAPLALLPGQRDGGGPDAARGRQQAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF7</accession>
    <name>A0A1E7NCF7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385723.1">
        <property type="nucleotide sequence ID" value="NZ_JNWR01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4152"/>
    <dbReference type="EnsemblBacteria" id="OEV38365">
        <property type="protein sequence ID" value="OEV38365"/>
        <property type="gene ID" value="HS99_0022595"/>
    </dbReference>
    <dbReference type="OMA" id="EIRGWQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="29355" checksum="8249117CDF311325" modified="2017-01-18" version="1">MLPASLDEAVDALAAAPAAVPVAGATDLMEAVNAGRLRPAALVGLGRITELRGWRYEDGGTAVLGAGLTHARMDRPDFAALIPALADAARTAGPPQVRNVGTLGGNIVTAAPAGDTLPVLAALEATVTLARAGASREVPVSHLLTGLDPVRPGELLTWVRVPLLHAPQVFLKATGRSGPARATASVALVLDPARRAVRCAVGAVAPVPLRPLEAEAWVAGCIDWDGSREIDPAAGAAFGEYVAAACVPDNYGAEGAWEAVTEGPTAAAVRLRRTVSVLARRALGRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCT0</accession>
    <name>A0A1E7NCT0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554980.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000583.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3084"/>
    <dbReference type="EnsemblBacteria" id="ARF82109">
        <property type="protein sequence ID" value="ARF82109"/>
        <property type="gene ID" value="B6264_27430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38492">
        <property type="protein sequence ID" value="OEV38492"/>
        <property type="gene ID" value="HS99_0021615"/>
    </dbReference>
    <dbReference type="OMA" id="RYPVRMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="27104" checksum="0187A4D9969BB2AD" modified="2017-01-18" version="1">MSQTVTRALRILAQLGEGERSLDQLAEVLGVHKTTVLRLLQSLEEERFVYRDAAYRYHLGAGLFALSGLALEQRGIRRIAAPHLAELNNATGQTVHLAAYEGGEVVYIDKFDSRHPVRMYSRIGLRAALHSAAVSKVLLADLPLPERRRVVAGIDFAPHTERTLTTPEALLAELEKVAAQGWAQDHAEHEAFINCVAAPIRDATGRVVAAASISVPDVVLPYEQVLDLLPQLLATARAVSADCGRPEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX0</accession>
    <name>A0A1E7NCX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene322"/>
    <dbReference type="EnsemblBacteria" id="OEV38532">
        <property type="protein sequence ID" value="OEV38532"/>
        <property type="gene ID" value="HS99_0021330"/>
    </dbReference>
    <dbReference type="OMA" id="WMATRGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29061" checksum="BC0ACE1BB1BA5E9F" modified="2017-01-18" version="1">MLRFVALGDSLTEGVGDQVDARWRGWAALLARSLAPEGRTVEFTNLACSGALTADLSERQLPAALARRPQLAAVLVGGNDTLRTGFDIRRTTMELDATLGELSGAGAVLLTACLPDPGMLLRLPSPLARPLARRMRAVNTVVHALTARHRAIHLHIADLPWCARRGLLSVDRLHPSAEGHHLIARRFHALLTTAGHPLGPPPAAEPAEAPPGLGADLWWMATQGTRWVAARSTDLLPGLLALAAAEGAARLRGSSGRHDDQMARATARALAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND29</accession>
    <name>A0A1E7ND29_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="10">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="10">DXP synthase</shortName>
            <shortName evidence="10">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dxs</name>
        <name evidence="11" type="ORF">HS99_0020115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551495.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene654"/>
    <dbReference type="EnsemblBacteria" id="ARF77606">
        <property type="protein sequence ID" value="ARF77606"/>
        <property type="gene ID" value="B6264_00530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38581">
        <property type="protein sequence ID" value="OEV38581"/>
        <property type="gene ID" value="HS99_0020115"/>
    </dbReference>
    <dbReference type="OMA" id="FAPQGMF"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="636" mass="67601" checksum="E83DAC176FF8927C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND49</accession>
    <name>A0A1E7ND49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000379.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene663"/>
    <dbReference type="EnsemblBacteria" id="ARF77600">
        <property type="protein sequence ID" value="ARF77600"/>
        <property type="gene ID" value="B6264_00485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38574">
        <property type="protein sequence ID" value="OEV38574"/>
        <property type="gene ID" value="HS99_0020070"/>
    </dbReference>
    <dbReference type="OMA" id="WYFRRAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="590" mass="62858" checksum="219F7398AEEC81F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND54</accession>
    <name>A0A1E7ND54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0020330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000152.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene612"/>
    <dbReference type="EnsemblBacteria" id="ARF77640">
        <property type="protein sequence ID" value="ARF77640"/>
        <property type="gene ID" value="B6264_00745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38611">
        <property type="protein sequence ID" value="OEV38611"/>
        <property type="gene ID" value="HS99_0020330"/>
    </dbReference>
    <dbReference type="OMA" id="DERDYTV"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23052" checksum="8773032AF29DE375" modified="2017-01-18" version="1">MPQPGSATVRSRVRIPLTFPDGYRAEAEVFTFHGLADGAEHLALALGAVPDGGTPLVRLHSECLTGDVFGSDRCDCGPQLRESVELISGAGGYLLYLRQEGRGIGLYNKLDAYALQDSGLDTYDANTALGLPEDGRDYTAAAQMLAALGIDGTGGTGGTGGTGGIDLLSNNPDKAAQLGRLGVTVRRRVPTGVHLSASNVRYLTAKVERTGHSIELSRLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND78</accession>
    <name>A0A1E7ND78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282964.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000437.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1786"/>
    <dbReference type="EnsemblBacteria" id="ARF77699">
        <property type="protein sequence ID" value="ARF77699"/>
        <property type="gene ID" value="B6264_01080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38666">
        <property type="protein sequence ID" value="OEV38666"/>
        <property type="gene ID" value="HS99_0020665"/>
    </dbReference>
    <dbReference type="OMA" id="WVTAEVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="459" mass="48380" checksum="3291C3A3163714D9" modified="2017-01-18" version="1">MPFSQPAVIRSRRAVLPTGERPADVLIRDGRIEQVAAHGSLVVGDGELVDLGDTALLPGLVDTHVHVNEPGRTEWEGFATATRAAAAGGVTTIIDMPLNSIPPTTTVDGLAVKRKTAEGQAWVDLGFWGGAVPGNVADLEPLHRAGVFGFKSFLAPSGVDEFPHVEAADLEAALAEQARIGALAIIHAEDPAVLAAAPQQPGVHYRDFLASRPPGAETAAVAHLLRTARRTGARVHILHVSSAAVLPLLRRAREEGVRVTAETCPHYLTLAAEQVPDGDTAFKCCPPIRDEANRDALWEALADGEFIAVVSDHSPSTPDLKLLPEYGGSGDFAAAWGGIASLQLGLPAVWTEARRRGHTLADVVRWMSTGPAELVGLTGTKGAIAPGCDADLVAFDPDGEFSVHAGELHHRNPVTPYAGRTLTGAVRTTWLRGRAVDTGAEPFGRQLTRPADSRPEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD2</accession>
    <name>A0A1E7NDD2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nitric oxide synthase oxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0020385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the production of nitric oxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 L-arginine + 4 O2 + 3 reduced [flavodoxin] = 5 H(+) + 4 H2O + 2 L-citrulline + 2 nitric oxide + 3 oxidized [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:52324"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the NOS family. Bacterial NOS oxygenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.47" evidence="4 10"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene601"/>
    <dbReference type="EnsemblBacteria" id="OEV38716">
        <property type="protein sequence ID" value="OEV38716"/>
        <property type="gene ID" value="HS99_0020385"/>
    </dbReference>
    <dbReference type="OMA" id="IWNHQLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017142">
        <property type="entry name" value="Nitric_oxide_synthase_Oase-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037219">
        <property type="entry name" value="NOS_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="SSF56512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOS" evidence="12">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037219-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS60001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV38716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="39301" checksum="634526239B5C9CD9" modified="2017-01-18" version="1">MRQFHREQPAAGTPESRLRAVREEIGRTGSYRHTPAELAYGAKLAWRNAARCIGRLYWRSLVVRDLRHLSAADDIAAECFEHLRLAGNGGRIRPVVSVFAPDLPGRPAARILNQQLVRYAGHRVDGAVIGDPAGAALAARARELGWKCAEDRFEPLPLLIQERPDERPHWYGLPDDTTLEVPLSHPDHAWFAELGLRWYAVPAISDMTLEIGGVRYPTAPFNGWYLGTEIGARNLADADRYDMLGTVAERLGLDTSSDRTLWRDRALVELNLAVLHSFQEAGVTVADHHTESERFLRHVAQEQRLGRPTPAEWSWIVPPVSGGLTPVYHRYYDPVDPEQRPAFLAREPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDK4</accession>
    <name>A0A1E7NDK4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="11" type="ORF">HS99_0018875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286328.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000292.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7326"/>
    <dbReference type="EnsemblBacteria" id="ARF81152">
        <property type="protein sequence ID" value="ARF81152"/>
        <property type="gene ID" value="B6264_21605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38744">
        <property type="protein sequence ID" value="OEV38744"/>
        <property type="gene ID" value="HS99_0018875"/>
    </dbReference>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="659" mass="74036" checksum="07EEA38417AEE13C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDS0</accession>
    <name>A0A1E7NDS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7370"/>
    <dbReference type="EnsemblBacteria" id="OEV38778">
        <property type="protein sequence ID" value="OEV38778"/>
        <property type="gene ID" value="HS99_0019090"/>
    </dbReference>
    <dbReference type="OMA" id="NDHSEAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24746" checksum="F30CE50844A12A22" modified="2017-01-18" version="1">MPARAVPQPPAPTAPTAPVPAGGTGHFVLPAGTPVQLPAHPPQRHAPAGPIAVLLIGPAGAGKTTVARYWAERRATPTAHISLDDVREWVQSGFANPQSGWNNASEAQYRLARRTCGFACRNYLANGISCIIDDAVFPDRPAIGLGGWKRHIGPGMIPVVLLPSLDSVLRRNARRSGTRRLGDEEVARIHGRMAGWYNSGLPIIDNSYLDVAGTAAELDRVILARLMGMPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU9</accession>
    <name>A0A1E7NDU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557882.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38808">
        <property type="protein sequence ID" value="OEV38808"/>
        <property type="gene ID" value="HS99_0019260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12317" checksum="3E8332D4A0F753E1" modified="2017-01-18" version="1">MTRTPGTSLRREPTLADARHRHRRQTHRAGPGRYGAQPSDPAPYAARAFAAAGTGTDTGHGDDRWEHGGFAVRFFPTSWWTGWPRAGTSPTSARSRRANRLAASGAPPQETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE86</accession>
    <name>A0A1E7NE86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557383.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4375"/>
    <dbReference type="EnsemblBacteria" id="ARF83237">
        <property type="protein sequence ID" value="ARF83237"/>
        <property type="gene ID" value="B6264_30320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39007">
        <property type="protein sequence ID" value="OEV39007"/>
        <property type="gene ID" value="HS99_0018050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="21341" checksum="DC6FA312424E2549" modified="2017-01-18" version="1">MPGTDHTPNHDSQVILLERGYAPTTMNGQLVAVPLNADCGDATCVPAIVDGQATAVPVFDVSAHLEAMAARMADHRRAIDALGPAPVAAAPAVDPGLSLAVRQYVLYGSIAALAAGGAVWMLGAAVAEVAPHAGQIGDLLKWAALLVALVVLGVSGLLGKLRSVAAGTGAGASANAAGEGASATGTVLALVHRTHTTTIGKQSAGWRGSISNHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA7</accession>
    <name>A0A1E7NEA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1016"/>
    <dbReference type="EnsemblBacteria" id="ARF83277">
        <property type="protein sequence ID" value="ARF83277"/>
        <property type="gene ID" value="B6264_30545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39046">
        <property type="protein sequence ID" value="OEV39046"/>
        <property type="gene ID" value="HS99_0018280"/>
    </dbReference>
    <dbReference type="OMA" id="YGVVNEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34011" checksum="5F25267286BE7A5E" modified="2017-01-18" version="1">MGRRALVTLTATSAALTAFTLPATAATRGGGAAPAHASQGGNDDQAITLDGSRAFPESVAADRHFVYAGSIGDGTVYRGRPGATTLEPFLPAGQDGRTQAAGIKITGNRLLVAGAFSGRFFVYSTSGRLVAAYTVPETGEQTLVNDAAVAPNGDVYITDSLRAVVYRIPAAEVDGPATGAHRTLRVAYHLPDYVAGQSNGNGITTAPDGTSLIIGYWYSGALYRLDLTTGGVRRIDAPPLPSADGIVRQGNTLYVARSVNNEVTELRLSAGSTRAVVVSERTFPGADTTTGVAVSGGRLLVTNSQMDTYLYGEPLTSPAFTIESLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF6</accession>
    <name>A0A1E7NEF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557155.1">
        <property type="nucleotide sequence ID" value="NZ_CP020568.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83325">
        <property type="protein sequence ID" value="ARF83325"/>
        <property type="gene ID" value="B6264_30870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39096">
        <property type="protein sequence ID" value="OEV39096"/>
        <property type="gene ID" value="HS99_0018600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20722" checksum="0A15921918CCBE73" modified="2017-01-18" version="1">MAVDSMRVGEAREWIGEAVVGAVRAGFARDHETMGYAERPAPEPAFKAGRERTGHDSSRVPEVPKALVESWTTDDTPGMFFTYKAEYGGPPLIQLSVRRTWARQVAAAGWAVLGGCAVLDVLDWDESVSPRRPARVRAALVWADYDAGMHGWRAHADNRDLRVAWGPQGQATLVMPWKEPSAGHEVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEY1</accession>
    <name>A0A1E7NEY1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3600"/>
    <dbReference type="EnsemblBacteria" id="ARF82464">
        <property type="protein sequence ID" value="ARF82464"/>
        <property type="gene ID" value="B6264_29540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39266">
        <property type="protein sequence ID" value="OEV39266"/>
        <property type="gene ID" value="HS99_0000675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="7705" checksum="F23A1A1111B78744" modified="2017-01-18" version="1">MHTAPARTGKGSRSQALADGSKVEIQQLGDQHHVAKLVHDGQILGTVEANGQNDGLDANGVHIVFGAGGEISAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF37</accession>
    <name>A0A1E7NF37_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550261.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3648"/>
    <dbReference type="EnsemblBacteria" id="OEV39307">
        <property type="protein sequence ID" value="OEV39307"/>
        <property type="gene ID" value="HS99_0000915"/>
    </dbReference>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="34"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25387" checksum="94A297980115FDA7" modified="2017-01-18" version="1">MCRVHEVQHAVLAKNDALAAALRADLRERDVVLVNLLSSPGSGKTALLERLLTRAVEDGVPVAAITADLATENDARRLARSGAPVKQVLTGGLCHLEAAQLRGHLDGWLPDGTRLLFVENIGNLVCPSSYDLGEELRVVLMSVTEGEDKPVKYPNAFGSANLVVLTKSDLAQAAGFDEPAFRGHVDRVNPGVPLLETSARTEQGIGRLWETVNGGAAVHQPVLARAAADGQHHHAAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF69</accession>
    <name>A0A1E7NF69_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288884.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000596.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1523"/>
    <dbReference type="EnsemblBacteria" id="OEV39356">
        <property type="protein sequence ID" value="OEV39356"/>
        <property type="gene ID" value="HS99_0001185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="6996" checksum="3CC9B880BA88F660" modified="2017-01-18" version="1">MGDLSNKAQELAGKVKEKAGDLTGNERLKGEGRADRGGAKVKQAAADVRDAMTGVADRVKGALKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA7</accession>
    <name>A0A1E7NFA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39173">
        <property type="protein sequence ID" value="OEV39173"/>
        <property type="gene ID" value="HS99_0000110"/>
    </dbReference>
    <dbReference type="OMA" id="GQWESRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19515" checksum="5CC77D009611289F" modified="2017-01-18" version="1">MLLACGAVAVLLYTEGQWESRSGGLMLVADLLNRPELLLGGALAALIAAAWLSDRRTAVRAASRAVTVTAGVVFLLGALAAHKVSAAETRSREDAPAGAQRTLVVVHRSYGSGSQAGEHWHVLLESGEGWSARRWLLADVGGAPDGARLVEASWTGREQITVVTDSYRRVFNLDQDSGEPVEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE7</accession>
    <name>A0A1E7NFE7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysR_substrate domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367025.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7539"/>
    <dbReference type="EnsemblBacteria" id="OEV39429">
        <property type="protein sequence ID" value="OEV39429"/>
        <property type="gene ID" value="HS99_0001640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="LysR_substrate" evidence="3">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="433" mass="45719" checksum="D6CD075EC47DF319" modified="2017-01-18" version="1">MFHKSPGKAKIVRRLQEGGRLIAPKTWPTSRRTLPAGHPLAQAEAVTAEHLAELPLVQLPPAVTKSFRTDRNPTRTPAGMPIPPGPTGGTLNEILTLVGAGWGAFPLGAQARRYHPRPDVAYRPLTGAPPVQWGLLTLVHGIAEAENGITRLQAWLPLVISAIAGVLFVLHERRATEPVLEPSLFHSSAFTVAALASLTLNFIAAGFSFALGQFGSVVLTLSPRTIGLLYLPGALLVAGAVVLAGRLIGRYTPRPVLITGMLVLVAGGLLMAVTAGPTMALWILVLATWLTNLGSLVASASVAETILSHAPPGRSGAVASVQPAFGMTGYALGPAVYLLLFNLFFRRQWLNDADARGLSETQAAQAVDATRSAMAQSPATVGYDPNLLRQAGLDLGLDFTDGLRLTMLVTSLLPLALAVAAYFLMPRRVRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF4</accession>
    <name>A0A1E7NFF4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0001260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556013.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1539"/>
    <dbReference type="EnsemblBacteria" id="OEV39365">
        <property type="protein sequence ID" value="OEV39365"/>
        <property type="gene ID" value="HS99_0001260"/>
    </dbReference>
    <dbReference type="OMA" id="MIIQMYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="48482" checksum="4E34B6434148EBF8" modified="2017-01-18" version="1">MYKNSRGRPGLVLAAVTVAQFVFALDMSVVNVALPAIRGALGFAPLDLSWVVHVYALTFGGLLLLGGRAGDLYGRRWLFRLGLAVFGLCSLAGGLAQQPWQLVAARAGQGIGAAAAAPAALAMLTTTFTEGPRRVRALGVWSAANAAGGALGVLVGGLLTEYASWRWVMLVNLPIVAAALVLLPTGTADGAQPVRRERLDVIGAVLATGGVGLLVFGVVRTDARGWGSPATLGTLAVAVALLAAFVLVEVRSAAPLLRLGLLRSRWVAGANVLVFLAAAGQFAAFYFVSLYLQQVLGLGAAATGAAFLPFSAGLVAGTVVATRITARRGPRAALVPGAVLAAAGLGWFALISPDGGFLSDVLGPSVVTSIGAGLVLAPVAAAATTGIAPREAGAASGLLNSSRQLGGCVGLAVLATVAAHATGTATDPGALSHGYALGLAAGAVLFALAAVVAATVLPRRRPAVPESRPVTIRSEKPLEGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI4</accession>
    <name>A0A1E7NFI4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285956.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000171.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7545"/>
    <dbReference type="EnsemblBacteria" id="OEV39434">
        <property type="protein sequence ID" value="OEV39434"/>
        <property type="gene ID" value="HS99_0001665"/>
    </dbReference>
    <dbReference type="OMA" id="CLRGKCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16744" checksum="A6CE74F277C79F1E" modified="2017-01-18" version="1">MTTLPPLLDALPEAHRDRLLALAHDRDFPDGSRLFDEGGPADRFWLVRSGEVALDVYVPGRPAPVVETLGAGQQLGWSWIFPPYRWHLGARAVGPVRAWELPAAEVRQLCADDPEFGYTLMRHCVEVIADRLQATRIRLLDLYAPVGGGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS6</accession>
    <name>A0A1E7NFS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367036.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5080"/>
    <dbReference type="EnsemblBacteria" id="OEV39485">
        <property type="protein sequence ID" value="OEV39485"/>
        <property type="gene ID" value="HS99_0001975"/>
    </dbReference>
    <dbReference type="OMA" id="AIQLPWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="111"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34392" checksum="B94C1FEA69499D2F" modified="2017-01-18" version="1">MTRGPTVSVPRLPRHPWTVFLGRRILRLFLSLAVVLTASFAMIRLIPGDPVRAALGVDAAPDLVAARRHALGLDTPFLTQYRHYLGGLLHGDLGTSLTTGTPVAELVRTRLPATLEIAGLAFLVTLAVALPGGLLVAVRTRDGRRPRSELAFTVVTAGLAGVPDFVLAAGLTALLAVGLQLLPVAGAAGVESFVLPVLALSLAPAAVLLRIVRMEALRVLGEDYLRTARSKRLSPARRYLRHAAPNTATAALTVAGSLLPALVAGTVLVEKVFAWPGIGSAMAQSVVAQDYPVVQAMVLVLGTTVLLAGLLVDVLLAVLDPRSAIREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ2</accession>
    <name>A0A1E7NFZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39413">
        <property type="protein sequence ID" value="OEV39413"/>
        <property type="gene ID" value="HS99_0001555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15386" checksum="201EC0DA6415EED5" modified="2017-01-18" version="1">MLSTPASEPEPLSSSQAEQAASFPNQLVSASEPLTCAGSSLPLMPLIDDDVRLRAAAEVVAGAALDGVAGAALDRVVGGWSADLAVETVEGRRPWEGVRVGPAGWSRAGMGSRRWGRARRRRWGRARRSGWWKARASPRRAAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ7</accession>
    <name>A0A1E7NFZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550311.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2741"/>
    <dbReference type="EnsemblBacteria" id="OEV39607">
        <property type="protein sequence ID" value="OEV39607"/>
        <property type="gene ID" value="HS99_0002735"/>
    </dbReference>
    <dbReference type="OMA" id="RWWPRRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="499" mass="51990" checksum="472865C3D49A23AF" modified="2017-01-18" version="1">MRKALNDLDARLFVRVASRRLRGTDPWLSRLTRAADHGKLWMTGAALLGATGNRTARRAALRGAGSLLLASALANVAAKGLTRRPRPALDPVPVVRRLLKQPATSSFPSGHSASAAAFATALAIESPLLGAIAAPVAAAVMASRVYVGVHYPGDVLAGAALGAGTAALTLRWWPRRSDHSASTAAPVVKAPALPTGEGLYLVVNGASGSGALTGADSAERSVEELRRELPDAHIRLCADGDDLAALLDQAAALAVTSDGALGICGGDGSVNLAAAVAAREGLPLAVFPGGTLNHFAVDLGTHILRATADAVKAGSACAVDVALATGDHGDRQLFLNTFSIGIYPELVRVRERLERRLGKWPALAVALVRVLAGAEPVRLTVSGVPRTLWMLFAGNGTYDPPGFAPTHRTSLDGGRLDIRAVDGSHPFARTRLLLAFLTGTLATSRVYREARLAALDLSDLHEVRNLAVDGEAFPAPDRLRLSKVTAALTVYRPERPAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG37</accession>
    <name>A0A1E7NG37_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279355.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2829"/>
    <dbReference type="EnsemblBacteria" id="OEV39679">
        <property type="protein sequence ID" value="OEV39679"/>
        <property type="gene ID" value="HS99_0003175"/>
    </dbReference>
    <dbReference type="OMA" id="YYMARYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="31441" checksum="FBE5286B1DA108D9" modified="2017-01-18" version="1">MAPPPTAARPLRRAASVLHRRAGLRLALLLSAPMAWLVLAYLGSLAVLLLSAFWAVDDFTYDVERVWNTANFSTVLTEPVYRAIALRTLGIAVAVTVIDAVVAFPMAFYMARVARPRTRKLLVVAVLTPLWASYLVKAYAWRVIFSQGGVLDWLVGPLGLSSPGYGTTAVIVVLAYLWLPYMILPVYSGLENLPANLLDASADLGASAGRTFRSVVLPQVLPSVFAGSVFTFSLSLGDYVTVRIVGGKTQVLGTAIADNVTLNLPLAAALSCVPVVLIVGYLLAVRRTGALESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG54</accession>
    <name>A0A1E7NG54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2798"/>
    <dbReference type="EnsemblBacteria" id="OEV39654">
        <property type="protein sequence ID" value="OEV39654"/>
        <property type="gene ID" value="HS99_0003020"/>
    </dbReference>
    <dbReference type="OMA" id="CLESFAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="41128" checksum="C951BEA31DF0210E" modified="2017-01-18" version="1">MAVVGRAASRSAANGPASLQDMRRQNLAVVLAAVAAHSPLSRADVSGRVGLTRAAVSSLVDELIGRGAVTEAAATASGRVGRPGRALTVSGEGPAGLGLEIGVGHLGACVADLRGEPRLWRRVERANAGRPPGTVLAELAALAAEAEAEAAALGLRVEGRVLAVPGVVPNEPRGLVERAPNLGWHTVGIADHWPEPETAPEPENEANLGALAEYWNAGTPVETFVHVSAGAGIGAALVIDGRLFRGARGFAGELGHVPVHPEGPECACGARGCLEQYAGEAAVLREAGLAQDGPGDPVALLAERAANGHAPTLAALDRAGRALGLALTSAVDLIDPDGLVLGGAYAELADWLLPSVCAELAARVTVRPWAAEALRPSALGRRGPLLGAALTTIRRIMADPTLLPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG63</accession>
    <name>A0A1E7NG63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000445.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2808"/>
    <dbReference type="EnsemblBacteria" id="OEV39664">
        <property type="protein sequence ID" value="OEV39664"/>
        <property type="gene ID" value="HS99_0003070"/>
    </dbReference>
    <dbReference type="OMA" id="LVFVQSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="30273" checksum="25A9FF63A0BCAF46" modified="2017-01-18" version="1">MAVNPGRRRAGARGLTGAGPFTYAVLILVAVLSLFPLYWTLVGASTSGSRIAQTPPPLLPGGNLWHNLDIAWNQVHMGQALLNSVVVASCVTASTVLFATLAGFAFAKLPFRGRNALLSLVVATMTVPAQLSVIPLYQIMARLHWTDRLQSVVLPNLVAAFGVFFMRQFLSEALPIELVEAARMDGASSLRILWSVVLPIARPGMAVLGMLVFVQSWNDFFWPLIALSQSNPTVQVALAGLGGGSYDSDQTVILTGALLGTAPLLLVFALLGRQVVGGITAGAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FAR4</accession>
    <name>Q9FAR4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Beta-ketoacyl synthase2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tcsE</name>
        <name evidence="5" type="ORF">HS99_0013275</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <title>Analysis of the chlortetracycline polyketide synthase genes from Streptomyces aureofaciens NRRL3203.</title>
            <authorList>
                <person name="Nakano T."/>
                <person name="Ikeda M."/>
                <person name="Mizukami T."/>
                <person name="Katsumata R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">NRRL3203</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762</strain>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="AB039379">
        <property type="protein sequence ID" value="BAB12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282574.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5203"/>
    <dbReference type="EnsemblBacteria" id="ARF80627">
        <property type="protein sequence ID" value="ARF80627"/>
        <property type="gene ID" value="B6264_18495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33523">
        <property type="protein sequence ID" value="OEV33523"/>
        <property type="gene ID" value="HS99_0013275"/>
    </dbReference>
    <dbReference type="OMA" id="TDHMTRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAB12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="41478" checksum="A9B1D45282CD78C3" modified="2001-03-01" version="1">MTDVVVTGIGVVAPNGWGVAEYWDATLAGRSGLGPLTRFDSTGYRAHVAGEVNFTPEEHLPGRLLPQTDHMTRLALVAAEEALADAGADPTTMPDFSAGVVTAASAGGFEFGQKELQALWSKGPAYVSAYQSFAWFYPVNTGQISIRHGMRGPGSALVAEQAGGLDALAKARRHVREGTALMLAGAVDGSLCPWSWLCLSRSGTVSPRRDPQRAFLPFDADASGGVPGEGGALLVLETPDGAAERGQHRHYGRIAGYAATFDPRPGSGRPPGLRRAIDTALADAGIGPSDVDVVFADASGVAEQDRAEAEVLGAVFGPRGVPVTAPKTMTGRLLAGGAPLDVAAALLSLRDGVIPPSVHIGRPAHPDLDLVRDRPRPARLGSALVLARGHGGFNSALVLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV58</accession>
    <name>A0A1E7MV58_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000131.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6898"/>
    <dbReference type="EnsemblBacteria" id="OEV32314">
        <property type="protein sequence ID" value="OEV32314"/>
        <property type="gene ID" value="HS99_0016540"/>
    </dbReference>
    <dbReference type="OMA" id="HEYCALT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="35553" checksum="D5E221D7BCE0E806" modified="2017-01-18" version="1">MDPATALRRIAFLLEWNDASPYRVRAFHTAADAVRALPPGPVDAARARRLPGVGPVTAEVIAQAAAGVTPTYLTRLESAAGPAARAGWELASAAAGDCHLHSDWSDGGHPIEEMAEAARALGHRWAVLTDHSPRLTIAHGLSPERLRRQLDAVAALNAEDGSFRLLTGIECDILEDGSLDQEPELLGRLDVVVASVHSKLRSDPEPMTARMLTAVSNPRTNVLGHCTGRIVTGRGRPPSRFDAEAVFAACAAAGTAVEINCRPERRDPPDDLLRLAVDAGCLFAVDTDAHAPEQLHWLTSGYARAARFGLGAERLVTTWPRERLLAWANPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVC6</accession>
    <name>A0A1E7MVC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0016890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289591.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6968"/>
    <dbReference type="EnsemblBacteria" id="OEV32374">
        <property type="protein sequence ID" value="OEV32374"/>
        <property type="gene ID" value="HS99_0016890"/>
    </dbReference>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="368"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="49715" checksum="9D687ED3CD46FC4D" modified="2017-01-18" version="1">MTRPIRVAIVGAGPAGIYAADALLKSDAAQAPGVSIDLFERMPAPFGLIRYGVAPDHPRIKGIVTALHQVLDKPQVRLFGNVDYPSDLALDDLHRYYDAVVFATGAMADRALDLPGIELDGSYGAADFVSWYDGHPDVPRTWPLEAEKVAVLGVGNVALDVARILAKTADELLPTEIPPNVYEGLRRNRAVEVHVFGRRGPAQAKFSPMELRELDHSPTIEVIVNPEDIEYDEGSIAERRAVKHVDLVAATVENWAIRDVGDRPHRVYLHFFESPVEVLGEDGRVVGLRTERTELDGTGNVRGTGRHTDWDVQAVYRAVGYYSDELPKLPFDPASGTVPHRAGRVLDGDGSHLPAVYVTGWIKRGPVGLIGHTKGDANETVACLLDDHAGGRLPGAAEPDPAAVEEYLRARGVRYTTWDGWKQLDAHERALGRAQERERVKVVEREDMLRNSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD7</accession>
    <name>A0A1E7MVD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289569.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6986"/>
    <dbReference type="EnsemblBacteria" id="OEV32388">
        <property type="protein sequence ID" value="OEV32388"/>
        <property type="gene ID" value="HS99_0016980"/>
    </dbReference>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12265" checksum="264FD3087D33D19F" modified="2017-01-18" version="1">MSDTLPPCPQCSSEYTYEMNALMVCPECGHEWAPADPDAQAGAGERVIKDSVGNVLSDGDTVTVVKALKVKGSASGIKAGTKVRNIRLVDGVDGHDIDCRIEGFGAMQLKSGVVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI1</accession>
    <name>A0A1E7MVI1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32440">
        <property type="protein sequence ID" value="OEV32440"/>
        <property type="gene ID" value="HS99_0017310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="16854" checksum="265509DDB8276880" modified="2017-01-18" version="1">MVRTGPNVGGAGRGGTVRTGAGAWSPEGCLAAAAVAVAVAAAVARGRAGACVCLVAEGSGAAPVPSSTGTAVGVSAGRGAGGAVVVSTAEAEAEAETETETEAAAEADGDAAAEGLDVAAASGAAGAVPGEPVSSCAPPIPATPRAQAHAATARARRLRVVVLPSCGPSPALSGTPLLHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK3</accession>
    <name>A0A1E7MVK3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000414.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1211"/>
    <dbReference type="EnsemblBacteria" id="OEV32462">
        <property type="protein sequence ID" value="OEV32462"/>
        <property type="gene ID" value="HS99_0017430"/>
    </dbReference>
    <dbReference type="OMA" id="NTTYQAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198467" description="LamGL domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="3">
        <location>
            <begin position="102"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="29178" checksum="9D97A81574297204" modified="2017-01-18" version="1">MTVRGSRLLAAVAVTGVLLAAPAATAAADTNQPQPIDRWKFAQAAGSPLSSPDEGSAHAAAVLGNGASVSPEEPLLPAPGFLRLDGATGYAEAAAASLHADRSFTLTAWANSSDPTRDMTVLSQGTGTTSSVALRWHYLGVDPYGGGPMGEWQATVADSDSPTAARTTVAHTANISVLENWTHLAVVYDADASRLTLYVDGQRENQSCEPDASGCTPHVSSAPSVRPFDAGAGLEFGRARTDGAWGEYFAGSLDDVWVHQGVLSETRIAQLADYNVELGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW15</accession>
    <name>A0A1E7MW15_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287899.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78346">
        <property type="protein sequence ID" value="ARF78346"/>
        <property type="gene ID" value="B6264_04915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32614">
        <property type="protein sequence ID" value="OEV32614"/>
        <property type="gene ID" value="HS99_0015165"/>
    </dbReference>
    <dbReference type="OMA" id="KTANRVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15768" checksum="FEF01E10AB62F990" modified="2017-01-18" version="1">MDATLAARGNTARARRRPGRRAALCLAAVTVLALGATACKVDTQTTADRVEVCSRVLGLTLFDPFPNDADKARKDVRERADKLDELAKIAPDDDLRKAVETTAKSLRDAQPKDHGARTVVDYLAEQNDRLRDLRKTCTDSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW21</accession>
    <name>A0A1E7MW21_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366250.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000414.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1212"/>
    <dbReference type="EnsemblBacteria" id="OEV32463">
        <property type="protein sequence ID" value="OEV32463"/>
        <property type="gene ID" value="HS99_0017435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="18727" checksum="969EAE2E1BBD992A" modified="2017-01-18" version="1">MNRTRLMSRPPARRSGQQVFVLLEDPDRADDFFVLLVDPVHREGLTLPGGSAEQDELPHLAARRHLEAETGLVLGLRTVLTIDYVPAAEFPEGVDFVYAGGMLTPQQADTVRRHQPPADIRGLHWVPQSKLREVMADDQYRRVDDAWDAWEHGAGLPLLIQGVPVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG2</accession>
    <name>A0A1E7MWG2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein meaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0016085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6102"/>
    <dbReference type="EnsemblBacteria" id="ARF78187">
        <property type="protein sequence ID" value="ARF78187"/>
        <property type="gene ID" value="B6264_03995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32768">
        <property type="protein sequence ID" value="OEV32768"/>
        <property type="gene ID" value="HS99_0016085"/>
    </dbReference>
    <dbReference type="OMA" id="QWSLRMQ"/>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="676" mass="72394" checksum="5AA861F8BEF4E62B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX07</accession>
    <name>A0A1E7MX07_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552507.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5741"/>
    <dbReference type="EnsemblBacteria" id="ARF81382">
        <property type="protein sequence ID" value="ARF81382"/>
        <property type="gene ID" value="B6264_22925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32968">
        <property type="protein sequence ID" value="OEV32968"/>
        <property type="gene ID" value="HS99_0013895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="8108" checksum="8C4423D0ACC328BD" modified="2017-01-18" version="1">MGFDQARVNRIFRPETYAEDVPYGLFRELRAEAPDRWVEESARGVGPEYPDPGSTGLQRAVRVLAQGLLSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI6</accession>
    <name>A0A1E7MXI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366937.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2689"/>
    <dbReference type="EnsemblBacteria" id="OEV33121">
        <property type="protein sequence ID" value="OEV33121"/>
        <property type="gene ID" value="HS99_0014825"/>
    </dbReference>
    <dbReference type="OMA" id="LYVIACG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17145" checksum="D29E1C1EFA7ADADB" modified="2017-01-18" version="1">MAVAGKPVLYVVVCAAGVAGGVGELVSAAQERGWEVGVVATPLAMGFIDVAAIEGQTGYPIRSAWRKPGEPRPLPDPDALVVAPATFNTINKWAAGISDTLALGILCESYGWGIPVAVQPCLSAAQAAHPAYGESLTRLRGMGVRIAEFAPGAYSWTRVLELLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXP5</accession>
    <name>A0A1E7MXP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33217">
        <property type="protein sequence ID" value="OEV33217"/>
        <property type="gene ID" value="HS99_0039210"/>
    </dbReference>
    <dbReference type="OMA" id="DGIWTCS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198552" evidence="1">
        <location>
            <begin position="34"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="22594" checksum="07751CD3C554238C" modified="2017-01-18" version="1">MVGRGAGAVAAAVALVAAVALGGTVSGMSVAEAKPAWGFAGRWACSGQPVDAGNVITDHDSAGCGGYGSWYQQPAKDGIWTCSGSPVVAGYVITDHLTSGCRGMGAWRHSLAHDGIWTCSGSPVVPGYVISNHLRAGCGGIGSWQHTHPHDGIWTCSGSPVVAGYVITGHMTTACDGAGAWRHNTARVGLWTCPGSPVPSGFRSTSYAAWACDGLGGWVLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY36</accession>
    <name>A0A1E7MY36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283872.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000158.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3411"/>
    <dbReference type="EnsemblBacteria" id="ARF80435">
        <property type="protein sequence ID" value="ARF80435"/>
        <property type="gene ID" value="B6264_17340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33334">
        <property type="protein sequence ID" value="OEV33334"/>
        <property type="gene ID" value="HS99_0012110"/>
    </dbReference>
    <dbReference type="OMA" id="YTVKDCC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21395" checksum="36BE913F46BE75D8" modified="2017-01-18" version="1">MSTTPALDPAHTALLVLDCQPAVLAVLPDDAAREALLGRIERAVADVRAAGGTVAHVRVAFTEADWDAVPDTNKSFGPLARHRAMHHQDPSTGFHERLAPRGDDIVVRKTRYGAMSTTDLDRQLRERGITTLVVAGTSTTGAVLSTVLDAADRDYLLHVLSDAVADPDPEVHDLLLRRVLPSRAHLVDTAGLPELLRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY50</accession>
    <name>A0A1E7MY50_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="8" type="ORF">HS99_0012320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290785.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000590.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4023"/>
    <dbReference type="EnsemblBacteria" id="ARF80472">
        <property type="protein sequence ID" value="ARF80472"/>
        <property type="gene ID" value="B6264_17545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33370">
        <property type="protein sequence ID" value="OEV33370"/>
        <property type="gene ID" value="HS99_0012320"/>
    </dbReference>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="209"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="460" mass="52554" checksum="EE32B650445E4261" modified="2017-01-18" version="1">MAADKIDTIVSLSKRRGFVYPCSEIYGGTRAAWDYGPLGVELKENIKRQWWRAMVQAREDVVGLDSSVILAREVWEASGHVATFNDPLTECMSCHKRHRADHLEEKYEAKHGFPPPNGLKDVNCPDCGTKGQFTEPKDFSGMLKTHLGVTEEAAGLAYLRPETAQGIFTNFRAVQTTSRKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGEDEQWHEYWLQQRWDWYVDLGLRTENMRFFEHPKEKLSHYAKRTVDIEYRFNFGGSEFSELEGVANRTDYDLRVHSEASGQDLKYFDQESGERYFPYVIEPAAGLNRAMLAFLIDAYFEDEAPNAKGVMEKRVGMRLDPRLAPVKVAVLPLSRNADLSPKARGLAADLRTAWNVEFDDAGAIGKRYRRQDEIGTPFCVTVDFDTLEDNAVTVRDRDTMSQERVSLDQVKGYLAARLIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY61</accession>
    <name>A0A1E7MY61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4016"/>
    <dbReference type="EnsemblBacteria" id="ARF80479">
        <property type="protein sequence ID" value="ARF80479"/>
        <property type="gene ID" value="B6264_17580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33377">
        <property type="protein sequence ID" value="OEV33377"/>
        <property type="gene ID" value="HS99_0012355"/>
    </dbReference>
    <dbReference type="OMA" id="QMRSTYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8632" checksum="901E0179AD44C75F" modified="2017-01-18" version="1">MGFVLVFLVALVATVVGTTLFLVRRERARRHWAGEIEGLSVEQHRTAQAAQMRSTYTSVAVHNGHGLFTDDLHKHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYW9</accession>
    <name>A0A1E7MYW9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000193_gene3686"/>
    <dbReference type="EnsemblBacteria" id="OEV33624">
        <property type="protein sequence ID" value="OEV33624"/>
        <property type="gene ID" value="HS99_0038670"/>
    </dbReference>
    <dbReference type="OMA" id="WHAPIAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="37913" checksum="A96EF2037EADAAE8" modified="2017-01-18" version="1">MPRLPDGVQDQQVLRIRFTDRDLALTRVAPAADMSAELSLSLHLLATRRPESRLGKWHEQLGRRWKPRSAMLFDLFAATDLPEFLIARPEGRDTAEATADGMDRDGRGYLRGLGRLRRLTPFARDLANGDHRSRVLLGDLTAEYQSAAITPYWEQIDAVVAAEHQYRTRQLATGGLNAVLATLHPAARWKPPVLSLPMSSPCVTELPLAGRGLVLQPAVFASGRLVIAGFERPEDPPVLIYPLPADRLLLTDDRVGPPPALTALLGRTRAVALDTLATGGPLSTSDLAAALGIAPATASQHASILADAGLTTKQRQGGTVLHHITLLGEVLLQGGVEHAAQSATRTLQAETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH9</accession>
    <name>A0A1E7MZH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6361"/>
    <dbReference type="EnsemblBacteria" id="ARF78764">
        <property type="protein sequence ID" value="ARF78764"/>
        <property type="gene ID" value="B6264_07390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33860">
        <property type="protein sequence ID" value="OEV33860"/>
        <property type="gene ID" value="HS99_0037255"/>
    </dbReference>
    <dbReference type="OMA" id="MLWVGSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40034">
        <property type="entry name" value="PTHR40034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9440" checksum="B51D17D1C809C06F" modified="2017-01-18" version="1">MPEPAGAPVPAVTPERVLAGLALLVPIVAMLWVSSYDKPDPAVAGMPFFYWYQLLWVPVSAVFTVAAYLLINRDEKARKAARNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK7</accession>
    <name>A0A1E7MZK7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0038630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1082"/>
    <dbReference type="EnsemblBacteria" id="ARF78967">
        <property type="protein sequence ID" value="ARF78967"/>
        <property type="gene ID" value="B6264_08595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33653">
        <property type="protein sequence ID" value="OEV33653"/>
        <property type="gene ID" value="HS99_0038630"/>
    </dbReference>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="33937" checksum="0F865C1F596BCBF3" modified="2017-01-18" version="1">MSKYLVTGGAGYVGSVVAAHLLEAGHQVTVLDDLSTGFREGVPAGAEFVEGRIQEAGKVLDGSFDGVLHFAASSQVGESVVDPEKYWRNNVAGSLELITAMRAAGVRKLVFSSTAAVYGEPEVVPIAETARTSPTNTYGASKLAMDHMITSEAVAHGLAAVSLRYFNVAGAYGAYGERHDPESHLIPLVFQAALGQRPHIAVFGDDYPTPDGTCIRDYIHVADLADAHLLALDAAKPGEHLICNLGNGSGFSVREVIESVKRVTGREIPVQVAARRAGDPAVLVASAERAHEALGWTPRRPNLDDIVADAWKFTLEKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM3</accession>
    <name>A0A1E7MZM3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Superoxide dismutase, Ni</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030057980.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6380"/>
    <dbReference type="EnsemblBacteria" id="ARF78747">
        <property type="protein sequence ID" value="ARF78747"/>
        <property type="gene ID" value="B6264_07295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33875">
        <property type="protein sequence ID" value="OEV33875"/>
        <property type="gene ID" value="HS99_0037350"/>
    </dbReference>
    <dbReference type="OMA" id="AHCDGPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14728" checksum="3427E007E77E1DC2" modified="2017-01-18" version="1">MFSRLFAPRATAHAHCDLPCGVYDPAQAKLEAESVKATQEKYQANEDPHFRARAIIIKEQRAEAVKHHISVLWSDYFKAPHFEKYPQLHKLINDTLKAASAAKASTDPATGQALLDLIAEVDKIFWETKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM8</accession>
    <name>A0A1E7MZM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551300.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6375"/>
    <dbReference type="EnsemblBacteria" id="ARF78752">
        <property type="protein sequence ID" value="ARF78752"/>
        <property type="gene ID" value="B6264_07320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33871">
        <property type="protein sequence ID" value="OEV33871"/>
        <property type="gene ID" value="HS99_0037325"/>
    </dbReference>
    <dbReference type="OMA" id="RYSTWKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="17558" checksum="8A268D800C9BC8DB" modified="2017-01-18" version="1">MIRTAVVTDVPVILAMIRELAEYEKAPQEAVATEEQLRESLFGANPAVFGLIAEDDATGEPVGFAVWFLNFSTWRGTHGIYLEDLYVRPAARGGGHGKALLLELARIAVERGYARVEWSVLDWNQPSIDFYKSIGAVPMDEWTVYRLTDEALRAAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN7</accession>
    <name>A0A1E7MZN7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551313.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6389"/>
    <dbReference type="EnsemblBacteria" id="ARF78740">
        <property type="protein sequence ID" value="ARF78740"/>
        <property type="gene ID" value="B6264_07250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33881">
        <property type="protein sequence ID" value="OEV33881"/>
        <property type="gene ID" value="HS99_0037395"/>
    </dbReference>
    <dbReference type="OMA" id="EWKEQAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="38806" checksum="908D55445E793E0D" modified="2017-01-18" version="1">MTPVFGHGRLRLYLLKLLDEAPRHGYEVIRLLEERFQGLYAPSAGTVYPRLAKLEQEGLVSHSTEGGRKVYRLTDAGRAELEARQGELDELELEIHDSVAQLAGAIREDVRDSAKDLREELWQAAKQAPRPGRDTGSGTGGDPWAGPWGDNESWQRAKEEFAQFKRQAKEQAKRAREQERAAKAKAKAAEEEARRLREQAKASRTAAQQEALRIKRRVEQQVREHAAKGDWPTGLAEGLSELTKGLAGLADAARWGHPTAEEQAEPADRTTVTRIDLDKDQDATATPADLPPWARTDPAGEPSRELERLLDRFRDQVRDAARDGGVNADRLAEASSVLGAAGERLKRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K4</accession>
    <name>A0A1E7N0K4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster assembly protein HesB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386337.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000324.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1957"/>
    <dbReference type="EnsemblBacteria" id="ARF79594">
        <property type="protein sequence ID" value="ARF79594"/>
        <property type="gene ID" value="B6264_12320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34206">
        <property type="protein sequence ID" value="OEV34206"/>
        <property type="gene ID" value="HS99_0037170"/>
    </dbReference>
    <dbReference type="OMA" id="HRYPGSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="23099" checksum="3F5DDF95A73953F7" modified="2017-01-18" version="1">MNVTVRLAQQPEADELLGRSALAALVGMLLDQQVPMEWAFTGPLTIAQRLGRDDLDAHEIATYSPEEFVALLSAKPAVHRYPAAMAKRVQQLCQFLVAQYDGDAAALWKDARTGKELLSRLNALPGFGKQKSQIFLALLGKQYGVRPEGWREAAGVYGEEGAHRSVADITGPESLALVREFKQETKRAAKEAKAAAKPRTTTRTATAAVSGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K9</accession>
    <name>A0A1E7N0K9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">HS99_0037115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1968"/>
    <dbReference type="EnsemblBacteria" id="OEV34215">
        <property type="protein sequence ID" value="OEV34215"/>
        <property type="gene ID" value="HS99_0037115"/>
    </dbReference>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17906" checksum="19CF8FC9E65744C0" modified="2017-01-18" version="1">MTVPYVPPLPAPVRPDPVRDRWAAPMRLAIAEAALAPATGDVPVGALVLGPDGEVLGRGHNEREAVGDPTAHAEVVAIRQAAGKAGEWRLGGCTLVVTLEPCTMCAGAIVLSRIDRVVYGALDEKAGAAGSLFDVMRDRRLNHRPEVIWGVLAEECGEQLRAFFDTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S0</accession>
    <name>A0A1E7N0S0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550807.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2591"/>
    <dbReference type="EnsemblBacteria" id="OEV34275">
        <property type="protein sequence ID" value="OEV34275"/>
        <property type="gene ID" value="HS99_0036735"/>
    </dbReference>
    <dbReference type="OMA" id="IDHEFIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="50215" checksum="A0C580CF053C8B59" modified="2017-01-18" version="1">MTTAVVVGSGPNGLAAAIRLAQEGVRVRVLEARETIGGGTRSGERTLPGLIHDDCSAFHPTGVASPFLRSLGLEEYGLRWLRAGAELAHPLDSGAAGVLWRDVDRTAAQLPPADGRTWRRVFGRLASNFDRLADDVLGPLLHVPAAPLALAEFGAQAVLPAPWTARQWSGEQARALFGGAAAHAFGSLGGPFGSAIGLMLVAVGHAHGWPVAQGGSQAVTTAMARLLQRLGGTVETGVEVLHLDQLDRPDLVLLDTGPHAAVRILGDRLPPRTARAYRRYRYGPAAFKVDLAVEGGIPWTNEHCRAAGTVHLGGTFEEVVAAEEATSRGRMPRRPFVLVGQQYLADPSRSAGDLHPVYAYAHVPHGYRGDATEPVLDQIERFAPGFRPRIRARYVRTAARLHSDNPNHVGGDITGGANTARQLLLRPRPTRDPYATGIPGVYLCSAATPPGAGVHGMAGFHAAQSALRHLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S7</accession>
    <name>A0A1E7N0S7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7637"/>
    <dbReference type="EnsemblBacteria" id="ARF78490">
        <property type="protein sequence ID" value="ARF78490"/>
        <property type="gene ID" value="B6264_05785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34300">
        <property type="protein sequence ID" value="OEV34300"/>
        <property type="gene ID" value="HS99_0036595"/>
    </dbReference>
    <dbReference type="OMA" id="EPFMVYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="30694" checksum="73A19C58D16C3812" modified="2017-01-18" version="1">MLQRQRQGSASVLYDIPGPRTRTRYRLFGVLALLGIAGLLWYAVSALADNGQFDADLWDPFQYNFVQQMIVDGLLSTLKAFGLAGAFSLALGALLASGTLSDHGPVRWVCTAIVQFFRAMPLLILIVALYYAFFAKDPMWALVLGLTLYNGSVQAEIIRSGVNAVPRGQGEAAYALGMRKTQVMSTILVPQAVRSMLPSMIGQLVVTLKDTSLGYIITYNELLFMGKKIASQPMNAAGFPYIPVVLVIAPIYIALCLLLTALARWIEARGRRGANRRTSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N110</accession>
    <name>A0A1E7N110_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283384.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3899"/>
    <dbReference type="EnsemblBacteria" id="OEV34351">
        <property type="protein sequence ID" value="OEV34351"/>
        <property type="gene ID" value="HS99_0036105"/>
    </dbReference>
    <dbReference type="OMA" id="WCAEHDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="127"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="648" mass="71053" checksum="49A94069A513C5C3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N160</accession>
    <name>A0A1E7N160_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555349.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1416"/>
    <dbReference type="EnsemblBacteria" id="ARF79234">
        <property type="protein sequence ID" value="ARF79234"/>
        <property type="gene ID" value="B6264_10190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34416">
        <property type="protein sequence ID" value="OEV34416"/>
        <property type="gene ID" value="HS99_0036010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="6859" checksum="8097D15BC7549D23" modified="2017-01-18" version="1">MDRPRPPRRPSLLLPAVLAVALPLAGAPVAVTAGVLLGDAVHRAVPSATVPSPGLPGAVTGLLVRAAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A6</accession>
    <name>A0A1E7N1A6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1067"/>
    <dbReference type="EnsemblBacteria" id="OEV34480">
        <property type="protein sequence ID" value="OEV34480"/>
        <property type="gene ID" value="HS99_0035685"/>
    </dbReference>
    <dbReference type="OMA" id="DHTGDWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025850">
        <property type="entry name" value="SUKH-3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14433">
        <property type="entry name" value="SUKH-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18228" checksum="B64286120B0E1F37" modified="2017-01-18" version="1">MPSPAAAGRTRPRFPADVAAELKASGWHPGRWQIRQAEEWADTLVGYGGPGGVPHAVFPAAVEAWAEFGGLAFDLSGPGRQLARTPFLIDPMCGLHQPRTLFDLGRALGTQLAPLGEEAYGQALLAVDQEGRVYSLDHTGEWFLGHGIDQALSTLVLGTAPGRLRTAEAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F0</accession>
    <name>A0A1E7N1F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550779.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2569"/>
    <dbReference type="EnsemblBacteria" id="OEV34517">
        <property type="protein sequence ID" value="OEV34517"/>
        <property type="gene ID" value="HS99_0035565"/>
    </dbReference>
    <dbReference type="OMA" id="RFNWQTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198648" evidence="2">
        <location>
            <begin position="30"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="904" mass="94948" checksum="916F2E449F553F96" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G3</accession>
    <name>A0A1E7N1G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550774.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2564"/>
    <dbReference type="EnsemblBacteria" id="OEV34522">
        <property type="protein sequence ID" value="OEV34522"/>
        <property type="gene ID" value="HS99_0035590"/>
    </dbReference>
    <dbReference type="OMA" id="MYDQRGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="30243" checksum="1A418B8DFDC0A1F4" modified="2017-01-18" version="1">MTFVDLDGLRCHVQRLGPQDGRPPAATAVLLHGLLTDSLASFYFTLAPALAAAGVEVLMYDQRGHGRTARPPAGYRLEQFVGDLERLLDRLAVTDRVHLVGNSFGGTVAFGLASRRPSQVACILAIESEPASPGWAGKLDGILRRSEQHLRDEDTLAWVATQRGAHTARLARSAGALLAGTSLARDIPASRLPAEAELRAIHCPVLAVYGSESDLADQAAWLDALLPDCRSVVVPGQEHSILIEAPDVVRELTLSWFAGHGVALRGPQAGRRLQPAVAKRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y2</accession>
    <name>A0A1E7N1Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737956.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene369"/>
    <dbReference type="EnsemblBacteria" id="OEV34473">
        <property type="protein sequence ID" value="OEV34473"/>
        <property type="gene ID" value="HS99_0035830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="21826" checksum="527B4577924AEE65" modified="2017-01-18" version="1">MPGGGAPGNAAAELEAASAPSTGAAGSTGAAAPTPTGSPTPSSTRTALPLSPVRQVAPGEKILVTDDTRIWFTANQRCDESRESDGSWHTSFGCRDVRSDNLEHDKPSVYAQTSGNRDRSVVASFYLGPTPSRIVAFFDGKPTVATIVTTAGMKGWTGYYVVLPPMPTGDPSAHRRPAGPAIGVYDAEGKLLAENPGTASDGSDERAPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z4</accession>
    <name>A0A1E7N1Z4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555953.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81934">
        <property type="protein sequence ID" value="ARF81934"/>
        <property type="gene ID" value="B6264_26340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34702">
        <property type="protein sequence ID" value="OEV34702"/>
        <property type="gene ID" value="HS99_0009440"/>
    </dbReference>
    <dbReference type="OMA" id="WLRRCNR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="905" mass="96521" checksum="AA8DF5E2D7981350" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N211</accession>
    <name>A0A1E7N211_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4636"/>
    <dbReference type="EnsemblBacteria" id="ARF81914">
        <property type="protein sequence ID" value="ARF81914"/>
        <property type="gene ID" value="B6264_26210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34724">
        <property type="protein sequence ID" value="OEV34724"/>
        <property type="gene ID" value="HS99_0009565"/>
    </dbReference>
    <dbReference type="OMA" id="VEQIWIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16292" checksum="6D20516D40B9A7A4" modified="2017-01-18" version="1">MSTTINKQVIRDFVAALNDRSGEGWVQLLSPSVIDHNKIIFGEEDAPGAAIEGFRLQLAAFSTEAAGDGFHIEQLIAEDDEVVARLRVAGVHTGYHARMPEPTNRRCDVEQIWIFTVRAGRIAEIRAVSDRLGMFLQLGWDWPTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N245</accession>
    <name>A0A1E7N245_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386421.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4604"/>
    <dbReference type="EnsemblBacteria" id="ARF81884">
        <property type="protein sequence ID" value="ARF81884"/>
        <property type="gene ID" value="B6264_26030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34752">
        <property type="protein sequence ID" value="OEV34752"/>
        <property type="gene ID" value="HS99_0009730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10534" checksum="C3AF6D1EFBF8DAA2" modified="2017-01-18" version="1">MPRRPTTAACGRIWRRGRRSSPRGALRLLLPPAAPGERAGTLAAYYVLSYLAMSIPAVLAGLLTNLYGLRTAVSPYAATVVLLTLIGLTRAMRQPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N283</accession>
    <name>A0A1E7N283_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737940.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81846">
        <property type="protein sequence ID" value="ARF81846"/>
        <property type="gene ID" value="B6264_25775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34792">
        <property type="protein sequence ID" value="OEV34792"/>
        <property type="gene ID" value="HS99_0009970"/>
    </dbReference>
    <dbReference type="OMA" id="GATTICG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="17835" checksum="8F4B6301FCF103B1" modified="2017-01-18" version="1">MLIKNARWGLSAAVLVVAGLALTACGPEDATSSDTPSASASSVPVATSSAHSGGRPTATASAANGQGSSSTSGGSGGSDTGHQRTLVGKLSYLAPGKLMVKPDNGGVDQAFMLSNATKVLGAAAICSRDGSTVTMDSQGYGTTNCTTDQLETAAKTGAVTVRVTLDSSLGLAQTVAEKYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L0</accession>
    <name>A0A1E7N2L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554115.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5878"/>
    <dbReference type="EnsemblBacteria" id="OEV34922">
        <property type="protein sequence ID" value="OEV34922"/>
        <property type="gene ID" value="HS99_0035005"/>
    </dbReference>
    <dbReference type="OMA" id="AARPNDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="32745" checksum="68E911842B5409F9" modified="2017-01-18" version="1">MSELTIPHVHHRHVDLDGLRVFYRETGPTDAPVLLLLHGFPSASHQYARLLDALGTRYRLIAPDYPGFGNSDSPAPDAFRYRFDTLADVTERFCLALGLDRFALYVFDFGAPVGLRLATRRPEWITGLVVQNGNAYEEGLSEQAREFIAHRRGVPGAEEAARSILTLDVTRSQYEGGTGDPSLVAPDGWTLDQHYLDLPGRKDIQVELALDYFSNLELYPAWQDWLRANQPPTLVLWGRNDPFFTEAGARAYLRDLPGAELHVFDTGHFALEEKLPEIAPLIDDFLARTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N7</accession>
    <name>A0A1E7N2N7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554869.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7685"/>
    <dbReference type="EnsemblBacteria" id="ARF78549">
        <property type="protein sequence ID" value="ARF78549"/>
        <property type="gene ID" value="B6264_06155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34952">
        <property type="protein sequence ID" value="OEV34952"/>
        <property type="gene ID" value="HS99_0034605"/>
    </dbReference>
    <dbReference type="OMA" id="LLYRMGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="24162" checksum="937A4C6E3593AB05" modified="2017-01-18" version="1">MDNLFGELRLGHLRLAPLGARRRTKVTASQAAAEYTGRWGWTVAPGDPATGTPGTGATAPTRCPCGSHRCAAPGLHPVPGSASRAATGAEGSVLFPTGRAFDVLDVPEQAGLQALVRLERMGTQIGPVLAPPTGRLQFLVAAGTARRLPDLLYRMGWDDAALDLTCHGEGSYVAAPPTVLGELGPVRWLRRPTRDNAGCPPEARLLLGTLAYACHRSRERTAEPAWMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N354</accession>
    <name>A0A1E7N354_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene385"/>
    <dbReference type="EnsemblBacteria" id="ARF82700">
        <property type="protein sequence ID" value="ARF82700"/>
        <property type="gene ID" value="B6264_08285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35128">
        <property type="protein sequence ID" value="OEV35128"/>
        <property type="gene ID" value="HS99_0034195"/>
    </dbReference>
    <dbReference type="OMA" id="YWQQGAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="34367" checksum="112F2A6D22A724DC" modified="2017-01-18" version="1">MHRSEPPDLAAALRTGPFHLALRTAITARGLALHRIRRHLALRGVNIGLTSLSYWQQGRRRPERPESLRAVAALEDVLDLPEHSLTRLLGPRRATTTVGPPVRPYRDLISPATAVDHLLATLASPRDTGLHTITHIERVRIGPDRQVTRRDSQHALRAHRDGIDRYLALYQGDPGSDISLVGVRAEENCRPGRIRRDHAHHLLAAELLLDRRLRAGDTHLLGYGFDDAPSPDPSCEYVRGFNSGAGQYVLQITFHPTALPVRCHRFALHSPGGAPYETEELTLDGHRCVHLVATAVRPCILGIRWDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N375</accession>
    <name>A0A1E7N375_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene416"/>
    <dbReference type="EnsemblBacteria" id="OEV35122">
        <property type="protein sequence ID" value="OEV35122"/>
        <property type="gene ID" value="HS99_0034040"/>
    </dbReference>
    <dbReference type="OMA" id="TRKGRWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="2">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="25226" checksum="06765E9F1D84FAAD" modified="2017-01-18" version="1">MSKPELEPRSGPVAAPRPSTAPVADAEMRVSDADRERIAELLRDAYAEGRLDAEEHAERIEAAYAAKTFGDLVPLTRDLPAHRSVSFDKPPLGAQEPAPAPARPLPPARQEAPSVVAIFGGAARKGRWRVGSHLSAFTAFGGVDIDLTDAVFESPEVEITVTAIFGGVEIRVPENVSLIGSGVGIFGGFDVREQTVADPYAPVVRVKGVALFGGCNAKPRRGKKLREWVRKQLGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N385</accession>
    <name>A0A1E7N385_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598167.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000940.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4444"/>
    <dbReference type="EnsemblBacteria" id="OEV35147">
        <property type="protein sequence ID" value="OEV35147"/>
        <property type="gene ID" value="HS99_0033720"/>
    </dbReference>
    <dbReference type="OMA" id="MHAMAGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="30703" checksum="61A39B957E6FBA5E" modified="2017-01-18" version="1">MRDLAYELRRLRGLRSTWLLLAAVLLCDVVVAAVLAGQAPAGPLAAPAGVRLLTAAVPLIPLPFAALGAGLLGALSYGHEVRHPGLAASQVTYFRRVRLLLAKLLVVGPVAALLALVTVLLDTVAVHLALPAGVTVPAWTDPEALSDRVSEALGAVGLGGPADLPGVFAPVALVVGHGVPAALLAFVLLTVVAAWTGVLTASLTRSAAAGVLLLCALPPLLESGVALLLRRTGRPWPTRAAELLPFQSGIEWAYGWVYGGAREAAAGSAALTDPALLAAVAVPAVALMLAALLVQVRRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U2</accession>
    <name>A0A1E7N3U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278729.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2437"/>
    <dbReference type="EnsemblBacteria" id="OEV35345">
        <property type="protein sequence ID" value="OEV35345"/>
        <property type="gene ID" value="HS99_0032510"/>
    </dbReference>
    <dbReference type="OMA" id="CQSVDLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046198">
        <property type="entry name" value="DUF6230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19741">
        <property type="entry name" value="DUF6230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="22213" checksum="9B65D10003EF4771" modified="2017-01-18" version="1">MAMSEDAAVAAETPTPTGTRRGRVRIKRTALMAVPAVAVGGILMTLTAQGVLAAQFSISGMPFTITADKLDGDGFAQFGSLDHMIPGSPNQGHTGGQVLVAVSAIKTAEITNLCQSVDLGGVNLVIHAGDQGTPVSASDLTTDSDLLSGDAEFKNIEIGGDASTYTKAGDVGKGGKGVFGQQADHVQLTHLNQHNYASTAVGFKLPNLRLSFSSKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A9</accession>
    <name>A0A1E7N5A9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286203.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7264"/>
    <dbReference type="EnsemblBacteria" id="ARF81097">
        <property type="protein sequence ID" value="ARF81097"/>
        <property type="gene ID" value="B6264_21255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35886">
        <property type="protein sequence ID" value="OEV35886"/>
        <property type="gene ID" value="HS99_0008480"/>
    </dbReference>
    <dbReference type="OMA" id="ECHYMND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="rRNA_proc-arch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="rRNA_proc-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="951" mass="105535" checksum="3898AC59651592F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N2</accession>
    <name>A0A1E7N5N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3356"/>
    <dbReference type="EnsemblBacteria" id="OEV35989">
        <property type="protein sequence ID" value="OEV35989"/>
        <property type="gene ID" value="HS99_0008215"/>
    </dbReference>
    <dbReference type="OMA" id="WLGHAWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="37518" checksum="DE769386FC13BAFC" modified="2017-01-18" version="1">MRERWRGWSRWRRGLLALGLAAAVPVAALGTVFVEIRLHYTGEPASGARTRGRDAVWLGHAWVDGRKTDADVAALAEQLAGTGVRDLYVHTGPLEHDGSLPASVHPRARWFTEAAHRALPGVRVQGWLGDEVKPEKDALDLDEAPTRDRVTASARQVLDQGFDGVHFDMEPIRPGTAGWLALLDEVRPVTAARGAVLSVAAAQIDPVPGLHTAGILLTDHGKWWDEAYFHETARRVDQVAVMAYDTSMPTEPLYGGYVAQQTELALRATPPQVDLLIGLPFFWDDKWGHWGDAETVPAAVRGVRLGLGRQGLGRANFGVALYVDFAATPENWAAYRRGWVDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5T8</accession>
    <name>A0A1E7N5T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282293.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6322"/>
    <dbReference type="EnsemblBacteria" id="ARF82685">
        <property type="protein sequence ID" value="ARF82685"/>
        <property type="gene ID" value="B6264_07595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36067">
        <property type="protein sequence ID" value="OEV36067"/>
        <property type="gene ID" value="HS99_0031530"/>
    </dbReference>
    <dbReference type="OMA" id="LFAHVPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="510" mass="53112" checksum="F7B0EFF5A75E096B" modified="2017-01-18" version="1">MSDLPFGFGVPPEEPEDGKAKPDDAQKKEQGQEGSGGPQPFGFGAGNPFGAMFGMPGAPGGPGGAGADNPFGAMFGGLNPGDLGAAFQQLGQMLSFEGGPVNWELAQNIARQTVVAEPAEGKSKDRSVGAAERAAVEEAVRLADLWLDGVTEFPSGAGTAVAWSRAEWIEATLPVWKDLVDPVAERVGTAMGGVLPEEMQAMAGPLMGMMRSMGGAMFGTQIGQALGALAGEVVGSTDVGLPLAPAGKAALLPQNVAEFGEGLNVPAEEVRLYLALREAAHQRLFAHVPWLRAHLLGAVEAYARGIKVDTSRMEELAGQLDPSNPEALQEALAGGLLQPEDTPEQKAALARLETALALVEGWVDAVVHAAAEPHLPQAGALRETVRRRRAAGGPAEQTFATLVGLELRPRRLRDAARLWALLADARGIEGRDALWQHPDMLPTAADLDDPDAFVHRGSGDLEGGFDFDALDKLLGEAAAGKPDLTKDERPKGDAPGTDQDGTDGKGEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z6</accession>
    <name>A0A1E7N5Z6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033350007.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80072">
        <property type="protein sequence ID" value="ARF80072"/>
        <property type="gene ID" value="B6264_15130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36126">
        <property type="protein sequence ID" value="OEV36126"/>
        <property type="gene ID" value="HS99_0031150"/>
    </dbReference>
    <dbReference type="OMA" id="MRVIHEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11449" checksum="B64FAAB4CC680DE7" modified="2017-01-18" version="1">MRVIHEMKFVARLASGADEWSCPACGRRVTLRRLPEPELTVLDPGDESAVHVGVIEPDARATAAAEKYGLGPVQNIPRPPSPPAPDAADRRWLAEIGIDWDGGDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N608</accession>
    <name>A0A1E7N608_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acyl-L-amino acid amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280956.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4960"/>
    <dbReference type="EnsemblBacteria" id="ARF80028">
        <property type="protein sequence ID" value="ARF80028"/>
        <property type="gene ID" value="B6264_14900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36084">
        <property type="protein sequence ID" value="OEV36084"/>
        <property type="gene ID" value="HS99_0030920"/>
    </dbReference>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="44770" checksum="C9142F48550E3199" modified="2017-01-18" version="1">MNRPEPAQPGTTLATASPAAELRDRVRRLEPELIAFRRDLHRHPELGRQEFRTTNLLRDRLVAAGLEPRVLPGGTGLLVDVVPAGTAPGAEFLAFRADIDALPIDDAKTDVPYRSTVPGRAHACGHDVHTSVVLGTGLVLAEAVRNGELRRPVRLVFQPAEEVMPGGALDVIKAGGMDGVGRIFAVHCDPKVEVGRIALRVGAITSACDRLVLHLDGPGGHTARPHLTTDLVTAIARMASDLPGALARRMDPRWGVSLVWGRIASGSAANVIPQHAELEGTVRCLELDGWREAPELLHELIAKLAETYRAKWTLDYHRGVPPVVNEAVSVGQLEAAMTARFAEDGAQVVEGTEQSLGGEDFSWYLEHAPGALARLGVRAPGDSTVRDLHQGRFDVDERAIGVGVELFSALALEADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P5</accession>
    <name>A0A1E7N6P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554776.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000931.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7729"/>
    <dbReference type="EnsemblBacteria" id="ARF82332">
        <property type="protein sequence ID" value="ARF82332"/>
        <property type="gene ID" value="B6264_28745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36376">
        <property type="protein sequence ID" value="OEV36376"/>
        <property type="gene ID" value="HS99_0029920"/>
    </dbReference>
    <dbReference type="OMA" id="MDYGWIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="41571" checksum="C7AB3818E78E8226" modified="2017-01-18" version="1">MTRLPDFRLETYFTRWEFTARHHLTASDSQTMTMAEVLALAGPKDREAWDNLALGYTETFGDPGLRQAIAGMYEQVEADDVICFGGAQEGINLAMQVLLEPGDHAVVLTPNYQSAETIPLSLCEVTGVALDERQDWALDLDAVEAALRPNTKVLSVNFPNNPTGTLIPAADFARLAGLCEERGIRLFSDEVYRGLEREPDRALPQAADLSATALSLNVTSKSLGLPGLRIGWIACRDRELRARLERAKHYTTICNSAPSEVLARIAITARERILARNRGIIAENLPVFDAFFAEFPELFEWRAPQGGCVAYPRYLGPDGVEDFCTALVEQAGVLLMPASMFRSDLTPTPTDRFRIGVGRRDPGPALDAFADWLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q1</accession>
    <name>A0A1E7N6Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36371">
        <property type="protein sequence ID" value="OEV36371"/>
        <property type="gene ID" value="HS99_0029885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="10152" checksum="879EC56AE3A4241A" modified="2017-01-18" version="1">MVGAGVVGAGTVGVGVAGGVAECDGAGVCDGVGVCEGVGVCEGVGVCEGVVLGTAVGLADGALVGVPVAVGLPVGVWPPQSTLKTFCLGLLTSGCSGSSPSTSGTAFQNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y6</accession>
    <name>A0A1E7N6Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoate polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ubiA</name>
        <name evidence="1" type="ORF">HS99_0030750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284244.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8050"/>
    <dbReference type="EnsemblBacteria" id="ARF79835">
        <property type="protein sequence ID" value="ARF79835"/>
        <property type="gene ID" value="B6264_13805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36223">
        <property type="protein sequence ID" value="OEV36223"/>
        <property type="gene ID" value="HS99_0030750"/>
    </dbReference>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="32367" checksum="515DF83C66907BF9" modified="2017-01-18" version="1">MRTVSTAAVETPGRTRAFLRLVMIEHSVFALPFAYIAALTAMFLADRRVHWGELFVVTVCMVGLRTFAMAANRIIDRELDARNPRTAGRELVTGAVSLRTAYVGSAVALVAFLGAAAMLNPLCLALAPVAVVPMVVYPYGKRFTNFPQAILGLAQAMGPVGAWLAVTGSWSWEAVVLGVAVGIWIGGFDLIYACQDVESDRENGVGSPPARFGVPAAIRGARVCHVLTTLLLGWFAVLTHAGPAFWIGLLVVAGAFVYEHTIVRPNDLSRLNRAFFQTNSFVGISLFFFALVDLVLRGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N727</accession>
    <name>A0A1E7N727_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1482"/>
    <dbReference type="EnsemblBacteria" id="ARF79197">
        <property type="protein sequence ID" value="ARF79197"/>
        <property type="gene ID" value="B6264_09935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36501">
        <property type="protein sequence ID" value="OEV36501"/>
        <property type="gene ID" value="HS99_0028645"/>
    </dbReference>
    <dbReference type="OMA" id="MNHVHSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7200" checksum="4393323DE70498B9" modified="2017-01-18" version="1">MNHVHSELPAVPGTTPMPEHRVAVSERGSFAFAACSCGWYSAARRSRDLARREAADHAAGYGSEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N744</accession>
    <name>A0A1E7N744_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0028605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555405.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1490"/>
    <dbReference type="EnsemblBacteria" id="ARF79203">
        <property type="protein sequence ID" value="ARF79203"/>
        <property type="gene ID" value="B6264_09975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36495">
        <property type="protein sequence ID" value="OEV36495"/>
        <property type="gene ID" value="HS99_0028605"/>
    </dbReference>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34753" checksum="218A9B2742E87295" modified="2017-01-18" version="1">MTSSSPAAPRGRERRPRDSRVGDKIFMNLARGAGILLLVIMAAIAGFLAWRSGMALSNNNGNFLTTFEWTPDAPKPVFGIAVLAFGTIVSALIAMVIAVPVAIGIALFISHYAPRRIAQPFAYLVDLLAAVPSIVYGLWGALFLIPHMDGLTSWLNQYLGWTYLFDQTRTGTPRNLFTVGILLAIMILPIITAVSREVFRQVPRMHEEAALALGATRWEMIRTAVLPFGRPGIISASMLGLGRALGETIAVAVVLSANSVLSLHILDAGGGTFAQNIALKFAEAGNNGRDALMASGLVLFVITLLVNGAARLIIARRKEYSGANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A5</accession>
    <name>A0A1E7N7A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03086 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289694.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7913"/>
    <dbReference type="EnsemblBacteria" id="ARF79121">
        <property type="protein sequence ID" value="ARF79121"/>
        <property type="gene ID" value="B6264_09495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36577">
        <property type="protein sequence ID" value="OEV36577"/>
        <property type="gene ID" value="HS99_0029090"/>
    </dbReference>
    <dbReference type="OMA" id="NHWVLYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="21012" checksum="25EE85C89BB539AF" modified="2017-01-18" version="1">MNVHPMHPFLARAAAAASGVAAAVPAGQPLDAPTPCGEFDTRALINHWVLYTSHGLEHRARRTELPGELVARDFTADADWRSAYAAQLERAVAAWGEPAAWEGDVDLGGSPVPAVGIARMLIIELVLHGWDVARAVGAEIEVDDELALLVREIVEENAELYRQYAGFAETVSVPDDASAWERALAASGRDPRWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Y7</accession>
    <name>A0A1E7N7Y7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552967.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000482.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36754">
        <property type="protein sequence ID" value="OEV36754"/>
        <property type="gene ID" value="HS99_0027455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198854" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="14854" checksum="563938FA04572CD2" modified="2017-01-18" version="1">MLCVAGIAPVALSGTAHAQGTCTVSGPTTTCTFAFTGAEQTFTVPSGVTQVDVTAIGAAGGLEGANKTPGGRGAQVSGTVTGLSAGQTLYVEVGGTPTLDASACYVFSPCIGGFNIDASVAHPFRHVRDRYAVAQAVRRRRRGVPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N849</accession>
    <name>A0A1E7N849_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4757"/>
    <dbReference type="EnsemblBacteria" id="OEV36824">
        <property type="protein sequence ID" value="OEV36824"/>
        <property type="gene ID" value="HS99_0027340"/>
    </dbReference>
    <dbReference type="OMA" id="ERQGPMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15046" checksum="CB915A54469BF040" modified="2017-01-18" version="1">MAARELRAVFSRLRRTLREKGQAASGLTPSQTAVLSRLITDGPASASALAAAERVRPQSMAATLAVLEGHGLVVRRPDPEDGRRQLVGLSETGLSWIADSRRAREEWLARAFQEDFTEVERATVLAALSLLDRLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M5</accession>
    <name>A0A1E7N8M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein mbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5979"/>
    <dbReference type="EnsemblBacteria" id="ARF81721">
        <property type="protein sequence ID" value="ARF81721"/>
        <property type="gene ID" value="B6264_25010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37004">
        <property type="protein sequence ID" value="OEV37004"/>
        <property type="gene ID" value="HS99_0004005"/>
    </dbReference>
    <dbReference type="OMA" id="RADCVEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7735" checksum="2B42CD24FA2F591B" modified="2017-01-18" version="1">MANPFEDADGTYLVLVNEENQHSLWPAFIDVPAGWTIAHGPDNRQACVDYVETNWTDMRPASLVAAMAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M7</accession>
    <name>A0A1E7N8M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556152.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7456"/>
    <dbReference type="EnsemblBacteria" id="ARF81681">
        <property type="protein sequence ID" value="ARF81681"/>
        <property type="gene ID" value="B6264_24745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37047">
        <property type="protein sequence ID" value="OEV37047"/>
        <property type="gene ID" value="HS99_0004260"/>
    </dbReference>
    <dbReference type="OMA" id="HILHALH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="37678" checksum="2BB98BCB1E030A37" modified="2017-01-18" version="1">MSRVLTTESAALQPDDVRIIRALQIAPRASFASIAAALGLTEGAVNRRYRRLRADGVIRVAGVVNPGALGQSRWLVRLRCRPGSGSAIADALAERDDVNWVALSAAGCEITCATQSRTREQREDLLGQRLPRTAAVIDINAFAMLRQFLGGRGHYWSALQGTLTPEEEAALGSDGPPFTESPVVTREPLRLTPEDEKLLAALAADGRAGLVDLAAASGLTPGRVSRRLDALLRRRAVHIDVEIAAAALGYHARANLWLRVHPSALKSAGRALAQEPEIAFAAALSGPWNLHAVAHCRDLDELFEFTSDRIGSLTGLQSMEVSPVLRHVKQAGTRLFGDRLVEPPGARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8V6</accession>
    <name>A0A1E7N8V6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pro-kuma_activ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6645"/>
    <dbReference type="EnsemblBacteria" id="OEV37136">
        <property type="protein sequence ID" value="OEV37136"/>
        <property type="gene ID" value="HS99_0004775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro-kuma_activ" evidence="2">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9382" checksum="757E6CCF522E5AB7" modified="2017-01-18" version="1">MASGPASAMNAAFQTDLGIYRSAEQGELRGREGELQIPSELAGVVTGVFGLDERRVARRATAQDTSTGVQGPFTPADLERHYDFPDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X1</accession>
    <name>A0A1E7N8X1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555707.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81601">
        <property type="protein sequence ID" value="ARF81601"/>
        <property type="gene ID" value="B6264_24240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37132">
        <property type="protein sequence ID" value="OEV37132"/>
        <property type="gene ID" value="HS99_0004755"/>
    </dbReference>
    <dbReference type="OMA" id="ESIAGIW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11078" checksum="C1B1C299CE33CDCE" modified="2017-01-18" version="1">MHERYDAASDLEDFPSDEVTAALTEIASDAQEDETLVALCAESLAGIWIARGAVERDVLARLPPWGRREVEQQVARSAPELLTSQQDAVAEVGDRDGRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N919</accession>
    <name>A0A1E7N919_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555682.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6638"/>
    <dbReference type="EnsemblBacteria" id="ARF81589">
        <property type="protein sequence ID" value="ARF81589"/>
        <property type="gene ID" value="B6264_24180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37144">
        <property type="protein sequence ID" value="OEV37144"/>
        <property type="gene ID" value="HS99_0004815"/>
    </dbReference>
    <dbReference type="OMA" id="CAYSAII"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027399">
        <property type="entry name" value="ADH_N_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13823">
        <property type="entry name" value="ADH_N_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="42166" checksum="BB59422187472246" modified="2017-01-18" version="1">MKAAVYEGPRTVTVKDVPDAKIEHPCDIIVKITTTNICGSDLHMYEGRTSFESGRTLGHENMGQVVEVGPAVRKVQVGEYVVLPFNIACGFCKQCEQGLTNYCLTMQPEPALAGAAYGFAEMGPYQGGQAELLRVPYGDFNALRLGEDAAERQTDYVMLADIFPTGYHATEMAHVKPGDQTIVFGAGPVGLMATYSALLRGAGRVWTADHQPDRLRKAEEIGAIPINTAEQNPAEVVKEATLGLGADNGCECVGYQAHDPQGHEDASLTLNGLIDSVRFTGHIGVVGVFLPHDPGGTEAQGELEAQGKVPIDFGMMWFKGQHMGTGQAPVKRYNRALRDLIVGGKAKPSFVVSHELSLDEAPTAYEHFDARDEGWTKVVLHPNGHGNGHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N960</accession>
    <name>A0A1E7N960_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737850.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000097_gene39"/>
    <dbReference type="EnsemblBacteria" id="OEV37219">
        <property type="protein sequence ID" value="OEV37219"/>
        <property type="gene ID" value="HS99_0005290"/>
    </dbReference>
    <dbReference type="OMA" id="LEHNEGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="19430" checksum="DDD51D697AF165DB" modified="2017-01-18" version="1">MDTVSPLPGRPDAAAIASSVVELLEVLWGGGRDLVAAPVSVSQLRVLYVLEASDGINLRTLTQALDTRPSSASRLCDRLEAIGLVQRNPSAASRRELELHLTASGRAFLAGLRADREQSLERVLEAMPDADRRALMSGLTSFRAAAMGITAQRTTSAGSHGVPGVEPVADASGHDVVRGVGPARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H1</accession>
    <name>A0A1E7N9H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555728.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81609">
        <property type="protein sequence ID" value="ARF81609"/>
        <property type="gene ID" value="B6264_24290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37123">
        <property type="protein sequence ID" value="OEV37123"/>
        <property type="gene ID" value="HS99_0004705"/>
    </dbReference>
    <dbReference type="OMA" id="HEANVVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046051">
        <property type="entry name" value="DUF6009"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19472">
        <property type="entry name" value="DUF6009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="14170" checksum="4B82618751B516D7" modified="2017-01-18" version="1">MSSLLQASDITHEDKVVWLEDPAELDYVRQALDKTPRRRGKPRYYRDGRMVGFAELCDTAEADPDSGLQKRRVFYLLPHDRDAEPDGLYRAGAPGEAVDPRTIEPRHVGMKTERSQQGSAAARTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V0</accession>
    <name>A0A1E7N9V0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0025960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7932"/>
    <dbReference type="EnsemblBacteria" id="OEV37470">
        <property type="protein sequence ID" value="OEV37470"/>
        <property type="gene ID" value="HS99_0025960"/>
    </dbReference>
    <dbReference type="OMA" id="MASWHAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="9528" checksum="20AF3146B7AE3036" modified="2017-01-18" version="1">MVGSRLIKVMASWHAHNPQPANGPYPGTGLIMPHRRPRRGELGDWQAEHNREHKQVRARIEHVFARMKTWKMLADLEVQCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAI0</accession>
    <name>A0A1E7NAI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552683.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7963"/>
    <dbReference type="EnsemblBacteria" id="ARF79081">
        <property type="protein sequence ID" value="ARF79081"/>
        <property type="gene ID" value="B6264_09255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37493">
        <property type="protein sequence ID" value="OEV37493"/>
        <property type="gene ID" value="HS99_0026100"/>
    </dbReference>
    <dbReference type="OMA" id="IGNIDNF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17752" checksum="F5480129C8C945DD" modified="2017-01-18" version="1">MNDFDFLYGTWDVANRRLTAPLSGGGAWEEFPGHSVVRPLFGGAGNIDEITFPTRGLRGVTLRLFDRETGQWAIHWSDSRTGRLDPPVTGGFTGDRGDFHGEDTLGGRPIRVHFTWYRLGPDSARWEQEFSADGGRSWELNWTMDFTRTGPAFDGLGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAQ2</accession>
    <name>A0A1E7NAQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000551.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3447"/>
    <dbReference type="EnsemblBacteria" id="ARF78105">
        <property type="protein sequence ID" value="ARF78105"/>
        <property type="gene ID" value="B6264_03500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37762">
        <property type="protein sequence ID" value="OEV37762"/>
        <property type="gene ID" value="HS99_0024505"/>
    </dbReference>
    <dbReference type="OMA" id="AWWQAHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="30679" checksum="019057C6F554BE36" modified="2017-01-18" version="1">MPRMLDVSDEVRSEIGDDEADRLLGGDRAPDSYECTSCRTPGDTHAEPTSTVLFIGDETAVLAFAHARCIPSQVVPVAEEQLAGAVRSISQSQPAAPNLTVPAPNLTLPAPDFTVPDHDFALPAQDAAGTPSQPIAPGQAAILGITCGLVLHGKVGHASLVVEPTGPVGRPGSTSGEDEFLDLLQDAGFQRVSDLDETPEQLPGWSVLVAMGKLHAILQPAAAGGSTGWWQAHQPLQVTDAWRMAASQLSEVTMYAVPAGMVGRQPREDLLRQALERAVALGQVVAASLPLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR1</accession>
    <name>A0A1E7NAR1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0024680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737831.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000545.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000091_gene7568"/>
    <dbReference type="EnsemblBacteria" id="ARF78076">
        <property type="protein sequence ID" value="ARF78076"/>
        <property type="gene ID" value="B6264_03320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37790">
        <property type="protein sequence ID" value="OEV37790"/>
        <property type="gene ID" value="HS99_0024680"/>
    </dbReference>
    <dbReference type="OMA" id="ANIRHAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34030" checksum="B7BD74A0C3680263" modified="2017-01-18" version="1">MTTSPDTKPAVTPPRSPSAAPGAVTLAQLPTSVWVTAQKDARNQRRGRYSPASAAHPAKMLPAIAAHAVATYTAPGQLVLDPMCGIGTTLVEAVHLGRNGLGVELEARWAAVARGNLNQARAQGAVGHACVKTGDARRTHALLGPDQYGRVQLLLTSPPYGASLHGQVVSSRESGQPGIAKFDGTYGDNPANLAHAATDELLEAFTTILTSCLPLLANGAYVAVTARPWRHHGELVDLPAAVIAAGQAAGLSPVERCVALLAGVRDGQLVARPSFFQLKNIRAARAAGVPMHLIVHEDVLVFQKPKHRPAPVRPDWPDAAAWQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW1</accession>
    <name>A0A1E7NAW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557051.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3741"/>
    <dbReference type="EnsemblBacteria" id="ARF78049">
        <property type="protein sequence ID" value="ARF78049"/>
        <property type="gene ID" value="B6264_03165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37815">
        <property type="protein sequence ID" value="OEV37815"/>
        <property type="gene ID" value="HS99_0024825"/>
    </dbReference>
    <dbReference type="OMA" id="AWIDRKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17836" checksum="E5E0EAA35BDEB0D2" modified="2017-01-18" version="1">MNTPSPDYLAQLLAEEKALQFAAFDNTTAFALGQVALDLAATAGLPVAILIRRNGQRIFQAALPGTGPDNDSWLDRKSRLVDRLGHSSYYLRNLAASKGTTVEEMYQVDPAQHAAHGGAFPITLAGTGVIGTIAASGLDQRDDHYFAVDAVRHFLERSKQSGEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB88</accession>
    <name>A0A1E7NB88_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="7" type="ORF">HS99_0024110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2057"/>
    <dbReference type="EnsemblBacteria" id="ARF79505">
        <property type="protein sequence ID" value="ARF79505"/>
        <property type="gene ID" value="B6264_11785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37951">
        <property type="protein sequence ID" value="OEV37951"/>
        <property type="gene ID" value="HS99_0024110"/>
    </dbReference>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="415" mass="42236" checksum="7C697DD574A2F51A" modified="2017-01-18" version="1">MKVLVIGGGAREHALCRSLSQDPSVTELHCAPGNAGIAQVATVHPVDQLDGALVADLAAKLGADLVVVGPEAPLVAGVADAVRAAGIPVFGPSGAAAQLEGSKAFAKDVMAGAGVPTARSYVCTTPEEAAEALDAFGAPYVVKDDGLAAGKGVVVTSDRAAALAHAASCERVVIEEYLDGPEVSLFAITDGTTVLPLQPAQDFKRALDGDEGPNTGGMGAYSPLPWAPAGLVQEVLDTVLQPTVDELRRRGTEFSGLLYAGLALTSRGTRVIEFNARFGDPETQVVLARLRTPLAGVLLASATGTLDQLEPLRWDEGAAVTVVIASEGYPAAPRTGDPIEGLAEAEADGTAYVLHAGTKADEDGRVLSAGGRVLSVTATGADLAEARDRAYAAVARISLKGGQHRTDIALKAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA2</accession>
    <name>A0A1E7NBA2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">HS99_0024205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278352.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000673.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2039"/>
    <dbReference type="EnsemblBacteria" id="ARF79522">
        <property type="protein sequence ID" value="ARF79522"/>
        <property type="gene ID" value="B6264_11880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37967">
        <property type="protein sequence ID" value="OEV37967"/>
        <property type="gene ID" value="HS99_0024205"/>
    </dbReference>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="109"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="18591" checksum="7BBD985AEDD759FC" modified="2017-01-18" version="1">MSNDRDALLAQIKDKAVVHGKVTLSSGKEADYYVDLRRITLDGEAAPLVGRVMLDATSHLEYDAVGGLTLGADPVATSMLHAAAARGQKLDAFVVRKTGKAHGLQRRIEGPEVKGRRVLAVEDTSTTGGSVLQAVEALREAGADVVGVAVIVERGGAGAVEEQGLPYVTAYTLDDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA8</accession>
    <name>A0A1E7NBA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278363.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000348.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2034"/>
    <dbReference type="EnsemblBacteria" id="ARF79525">
        <property type="protein sequence ID" value="ARF79525"/>
        <property type="gene ID" value="B6264_11905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37971">
        <property type="protein sequence ID" value="OEV37971"/>
        <property type="gene ID" value="HS99_0024230"/>
    </dbReference>
    <dbReference type="OMA" id="FRTYFMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20507" checksum="D775AAC2202E2984" modified="2017-01-18" version="1">MSIDPSSIPSFGVPQGGQPGGQGGRPAGPPPIIVPDQALVTQLLDQMQLKHVVDEEGDLTAPWEGFRVYYMFRGEQKELFAVRAFYDRAYPLEKKGEILDLIDEWNRETLWPKVYTHTHEDGVVRLIGEAQMIVGTGVNLDYFVTTTANWTQAAVGFEQWIVERLGLQNEIEGEDGEGEDGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC1</accession>
    <name>A0A1E7NBC1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2018"/>
    <dbReference type="EnsemblBacteria" id="ARF79540">
        <property type="protein sequence ID" value="ARF79540"/>
        <property type="gene ID" value="B6264_11985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37985">
        <property type="protein sequence ID" value="OEV37985"/>
        <property type="gene ID" value="HS99_0024305"/>
    </dbReference>
    <dbReference type="OMA" id="PWPKALG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="32111" checksum="1AF4B150550985BC" modified="2017-01-18" version="1">MDGPEYFTSAHPTVGGLGGPGGHGSGPGATVGDGYDPYAADRPGNTRAFPLGDPYEPQRDPYHRQQPYYAPPPGPYDDDGGYGQQPPYGHQPPPPYGGQDQHPPYGQDNVTTYRAGGQSAPHVSGPRPQWRELFVGIFRTPTAIFDRTRDHQVWLPALTVSLLYGVLAVLGIGLTHDDIVNSTFSVALTGLFAAAVGFTVAGAVFGAVTYALARQLGGDGPWKSTVGLAALIGWLTDAPRLLLDLVLPSGSAVVQAVGWATWLLCAYLLTGMVRRVHDLPWGKAAGAAAVQLVALLVLIKLPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC9</accession>
    <name>A0A1E7NBC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388083.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1998"/>
    <dbReference type="EnsemblBacteria" id="ARF79559">
        <property type="protein sequence ID" value="ARF79559"/>
        <property type="gene ID" value="B6264_12095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38000">
        <property type="protein sequence ID" value="OEV38000"/>
        <property type="gene ID" value="HS99_0024410"/>
    </dbReference>
    <dbReference type="OMA" id="RMVRWWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="22978" checksum="F27C57C1931A1A09" modified="2017-01-18" version="1">MRENPKSPKSRSQESSARLAAALTAAVEHRWPVVPGTVLCGGRCSCGDPDCPAPGAHPHDPSLLAATTDARMVRWWWERQSPDAPVLAATGSAVSAVSLPAAAGARALVHLGALRLPLGPVLAMPGRYALLVAPYSLDALGEMLAQLPWVPGTLRYHGPGGFLPLPPGGGAMGLPPAGGWGRVRWVLAPRPAGGGGVRLPQVGPLLGELVDATVRLDSGRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ9</accession>
    <name>A0A1E7NBJ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555045.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000825.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3034"/>
    <dbReference type="EnsemblBacteria" id="ARF79724">
        <property type="protein sequence ID" value="ARF79724"/>
        <property type="gene ID" value="B6264_13150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38065">
        <property type="protein sequence ID" value="OEV38065"/>
        <property type="gene ID" value="HS99_0022950"/>
    </dbReference>
    <dbReference type="OMA" id="HDFPDYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="38563" checksum="76C96BA6B6532F7F" modified="2017-01-18" version="1">MESELHSIGELARASGLGVGTLRYYDGAEVLTPAWVDPQTGYRWYRPAQLADARLLARLRRVGLPLTAIRAVLAAVPGSGEAERVLDAHLRRLEDGLSDARRELSLIRTTIEQREHPMTTTPAELRLTVRADGLAAALDAVRFAVCGDPELPSLAGVLFEPDGPVLRLVATDRYRMALAELPALGAPQQPTAGSTVPTALVDALRALLPTGPTEIALTLGAGTFRAETPDHRVEGTTVDLDYPDHRTLTRLDPRHRITLPAAELRAAVEAGATCTLPSGPHGADCQVTLLTLTEDGHLTVADDPAPEDFQVAVNRDFLLDALRAGHPGQLLLELGGPIAPLAIRTPGRTGTFSVLMPVRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS7</accession>
    <name>A0A1E7NBS7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1905"/>
    <dbReference type="EnsemblBacteria" id="OEV38156">
        <property type="protein sequence ID" value="OEV38156"/>
        <property type="gene ID" value="HS99_0023490"/>
    </dbReference>
    <dbReference type="OMA" id="HEVYRYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="422"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="634" mass="68772" checksum="BFF4BB4BD471AC06" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW5</accession>
    <name>A0A1E7NBW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0022955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38182">
        <property type="protein sequence ID" value="OEV38182"/>
        <property type="gene ID" value="HS99_0022955"/>
    </dbReference>
    <dbReference type="OMA" id="HNVANPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="82"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28618" checksum="01107852D322A8AD" modified="2017-01-18" version="1">MLGSVADAEDLVQDTWLRWSQVTGPVASPGGYLARTVTNLALNRLDSAAVRRESYVGPWLPEPLVTEPDATDGVERAETVSLALLVVLESLSPLERAVFVLKEAFGFSYQEIAEALDRTETACRQVGSRARAHVRARRPRFDAPPELRRRATDEFLAACVGGDLNRVLALLAPDVTTWSDGGGVITAAVRPVTGADNVARFLLGLLRKLGDGVGARPVLVNGQPGLLITVDGAVDSVSVLDFTEGPDGSLLVSEIRAVRNPHKLAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC27</accession>
    <name>A0A1E7NC27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290029.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3299"/>
    <dbReference type="EnsemblBacteria" id="ARF80282">
        <property type="protein sequence ID" value="ARF80282"/>
        <property type="gene ID" value="B6264_16420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38208">
        <property type="protein sequence ID" value="OEV38208"/>
        <property type="gene ID" value="HS99_0021860"/>
    </dbReference>
    <dbReference type="OMA" id="KFPDGWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="450" mass="48013" checksum="A562C9A81277AA90" modified="2017-01-18" version="1">MMSEQPPGAAADAAVARILAATVHPSAGAPRGVVVDSPPGAGKSTLVVRAARELVAAGERLMIVAQTNGQVDDLVGRLAEKAPELTIGRLHAADSRPGPEVLRHANVTPSDKVADLVEQDVVISTSAKWQWVRAEAPWRHAIVDEAYQMRSDALLAVARLFERALFVGDPGQLDPFTVVGTEQWAGLSYDPSSSAVVTMLAHNPQIEPHRLPVSWRLPASAAPLISRAFYPYTPFRSGTGPEDRRLTPAVRPDGSALDAVIDRAAEHGWALLELPARHTVRTDPQAVAAVAATVRRLLERGLTARSEQGEAPLTADRIAVGTAHRDQAAAVRAALLKVGVPVDGTTGPAVTVDTANRLQGREYDVTVVLHPLSGRPDATAFHLETGRLCVLASRHRHACIVVARAGIAELLDEHPSTEPVQLGVPVAFPDGWEANHQVLEHLSGHRVHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCA2</accession>
    <name>A0A1E7NCA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385846.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80177">
        <property type="protein sequence ID" value="ARF80177"/>
        <property type="gene ID" value="B6264_15785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38305">
        <property type="protein sequence ID" value="OEV38305"/>
        <property type="gene ID" value="HS99_0022485"/>
    </dbReference>
    <dbReference type="OMA" id="AAAGHEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="7947" checksum="183EC64E470F5569" modified="2017-01-18" version="1">MPRPSAVQFCLGSFTVVATTVALLAVSGASGALEVGVLVAFALALGTVVTALSVSVSTRSAAVADGSGASPAAAGHEYARQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC4</accession>
    <name>A0A1E7NCC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000782.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4170"/>
    <dbReference type="EnsemblBacteria" id="ARF80174">
        <property type="protein sequence ID" value="ARF80174"/>
        <property type="gene ID" value="B6264_15770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38308">
        <property type="protein sequence ID" value="OEV38308"/>
        <property type="gene ID" value="HS99_0022500"/>
    </dbReference>
    <dbReference type="OMA" id="GVFRPCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14942" checksum="279C77BF3A164AD3" modified="2017-01-18" version="1">MDRPVSVVEHELELNLVLSPEHSVPVPARLTYGSHDPYAVYITFHLDTGSPVTWVFARELLVEGTFRPCGQGDVRIWPTRSGRRSVLCLALSSPAGDALLEAPLPAVAAWLERAHRLVPPGSELAALDLDGSLAELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF6</accession>
    <name>A0A1E7NCF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554374.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene460"/>
    <dbReference type="EnsemblBacteria" id="ARF78853">
        <property type="protein sequence ID" value="ARF78853"/>
        <property type="gene ID" value="B6264_07925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38163">
        <property type="protein sequence ID" value="OEV38163"/>
        <property type="gene ID" value="HS99_0023530"/>
    </dbReference>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="33751" checksum="6B8BC3B3EC91BC2E" modified="2017-01-18" version="1">MASEVAAFRGVGKSYGRVRAVDGLDLVLRPGETVALLGPNGAGKSTSLDLLLGLREPDQGSVTLFGGTPRAAIADGRVGAMLQSGGLMTDVKVRELVELACKVHPRGRSVTGVLTDAGITEIAERRVDKLSGGQEQRVRFALAIAGDSDLIVLDEPTTGMDVSVRQGFWASMRAQADAGRTVLFATHYLEEADSIADRVLVLHRGRLIADGSSAEIKARAGARRIAFEIHDVDLSSAAVPFDETVLRALPGVQSLDVTARVPGVRTVRIRTADADAGVAGIYRAGLYPRGLEVTGVGLEQAFLTITGELDKQDLAEESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCG1</accession>
    <name>A0A1E7NCG1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554452.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene250"/>
    <dbReference type="EnsemblBacteria" id="ARF82223">
        <property type="protein sequence ID" value="ARF82223"/>
        <property type="gene ID" value="B6264_28085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38386">
        <property type="protein sequence ID" value="OEV38386"/>
        <property type="gene ID" value="HS99_0020970"/>
    </dbReference>
    <dbReference type="OMA" id="SHEHNQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="27958" checksum="E1A956605D85A884" modified="2017-01-18" version="1">MPDLLERVSAFRASFARRDAGEIVELPEYPGVFAVRNADYVLSHEHNQLIVTGPGTDPAALPGLAARWLGQRRQYAITVLDEEWGERATPVLAEAGYERGTAVVMVRDTAGCELPEPAALPTEFADLREAVLRQQSEWYEGEELIRQLTDRRPTRLRGAEQVHFLAARSADGGVAAWVDLYLEPAAGLAQVEDLVTAAPHRRAGHGDTLLGSGLALAAAAGIPQLFLLADADGWPREWYARRGFTGIGRSHSFHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ4</accession>
    <name>A0A1E7NCJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556887.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3292"/>
    <dbReference type="EnsemblBacteria" id="ARF80288">
        <property type="protein sequence ID" value="ARF80288"/>
        <property type="gene ID" value="B6264_16455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38203">
        <property type="protein sequence ID" value="OEV38203"/>
        <property type="gene ID" value="HS99_0021825"/>
    </dbReference>
    <dbReference type="OMA" id="KAHWGYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16034" checksum="5A2866F1C1E438CA" modified="2017-01-18" version="1">MHIRPACPDEAGLLTGIALRAKAYWGYDEAFMAACREELTLDAAAVERASTVVAEDGGRVLGFAVLTGAAPSGELAMLFVEPDRIGGGIGRALFEHVREQARAAGLRRLTIDSDPNAEPFYLAMGATRIGSTPSGSIPGRELPLLEVELAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM6</accession>
    <name>A0A1E7NCM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283201.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000707.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene269"/>
    <dbReference type="EnsemblBacteria" id="ARF82206">
        <property type="protein sequence ID" value="ARF82206"/>
        <property type="gene ID" value="B6264_27990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38404">
        <property type="protein sequence ID" value="OEV38404"/>
        <property type="gene ID" value="HS99_0021065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="7001" checksum="9B8B956635F0718D" modified="2017-01-18" version="1">METLAYGVQADERPLLERAFAGRHGLRCLDVTRTAVGQIIDATARNIDDFAAGRRSENTLGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ4</accession>
    <name>A0A1E7NCQ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3075"/>
    <dbReference type="EnsemblBacteria" id="ARF82118">
        <property type="protein sequence ID" value="ARF82118"/>
        <property type="gene ID" value="B6264_27475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38486">
        <property type="protein sequence ID" value="OEV38486"/>
        <property type="gene ID" value="HS99_0021570"/>
    </dbReference>
    <dbReference type="OMA" id="HDFVAHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="40927" checksum="778007C93A44B660" modified="2017-01-18" version="1">MRTDPLTRPDRSRRWPTVTAALLLFAPAALAHPGDRGAALLLALTAALAAVVALLAWPLGRVTLATAAGAAAGASLLVDLCYPGPYRLPAFWAPFEWLALIGVLFRAVRRLPDRWAGPIGGLVGLAAVVLPLRFALRMPQGGAAGPVGGVLFSLLPVLGVGGASLYLRVLDARRERAVARARREQRLEVARGLHDFVAHEITGIVLEAQAGQLPGPETEETATLLRRLEEAGLRALDSMDEMVGALRGDQEAAGTTRRPGLADLPELVARFGTKGGPRATVDLAPGVVGLLSAEAQATAYAVVLEALTNVRRHAPQAAVVTVRVAPEPDGRAVRLTVGDTGGPATRRLRLRRRPGTGGTGLAGLAARAAAHGGTLTSGPLGPSGWEVCCTLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCS9</accession>
    <name>A0A1E7NCS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386662.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000450.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3078"/>
    <dbReference type="EnsemblBacteria" id="ARF82115">
        <property type="protein sequence ID" value="ARF82115"/>
        <property type="gene ID" value="B6264_27460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38487">
        <property type="protein sequence ID" value="OEV38487"/>
        <property type="gene ID" value="HS99_0021585"/>
    </dbReference>
    <dbReference type="OMA" id="FWNGAGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="36356" checksum="A9C945C6B4F07A52" modified="2017-01-18" version="1">MSTPQTIAAAPTLGHSLKHLAVHLLTPLLMCLGMALAYQGAFHQPEPHHLKVAVVGAGPQAHGLAQAIQGKAGDALDVRTVDDRATAEQQLRERDLVGAFVPDAGSPELIVAKGNSDTSVVAATAVFTNVTDKQGVPLHVTDLTTLAEGDPTGQGLFFLLVALSIGSYASVAAIGAAGAGLSLRIRALVGVAVSLVVSVIGIVTAGPVFHVVDHDYAAIWALGWLYSAGIVLIGIGLHSFLKKWTTLALMVLFVMLNFTSSGGIYRPELQNGFFGSLHGFWTGAGYLEGARSIMYFDGGAGLGGHVLTLVVWLLLGGAALVAAALYEGRGRRPVETPVEAEEEMEEAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU2</accession>
    <name>A0A1E7NCU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288430.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000653.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3066"/>
    <dbReference type="EnsemblBacteria" id="ARF82126">
        <property type="protein sequence ID" value="ARF82126"/>
        <property type="gene ID" value="B6264_27520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38478">
        <property type="protein sequence ID" value="OEV38478"/>
        <property type="gene ID" value="HS99_0021525"/>
    </dbReference>
    <dbReference type="OMA" id="CMIPIGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="45889" checksum="44B4075AFE124262" modified="2017-01-18" version="1">MTTVAAPPVRSLRPLVGVLAATAVSLTGTRVSAIALPWFVLATTGSATLTGLVAFAEMTPYVLVKALTGPLVDRLGPRVVSWTTDAASAVAAGLVPLLHAQGLLPFWTLLVMVAVIGAMRGPGDLAKSVMVPEAADRARVPMERATGLSGVTERLASTIGPAVGGGLVALVGPLAGLAVNAGTFALGSLIIALALPPGMGRSAVPEAASSTVPVEPDQRDGGYWRMFREGFGFLRTEPLLLTVTIMVGITNLLDAGFSTVLLPVWARESGNGPAGIGLIGSVLGVTAVAGSLIAATLAHRLPRRTVFFVGFLLAGAPRYLVLALDAPMWAVVAVFAVGGFGSGFLNPILGAVLFERVPRHLLGRVHALSDSLAWAGIPLGGLLAGAAVALVGLIPSLLTAGVLYFATTTLTGLRPEWREMDRQRGHGRAEAGEQVTDGAEDALEAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND72</accession>
    <name>A0A1E7ND72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366401.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene303"/>
    <dbReference type="EnsemblBacteria" id="ARF82175">
        <property type="protein sequence ID" value="ARF82175"/>
        <property type="gene ID" value="B6264_27815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38433">
        <property type="protein sequence ID" value="OEV38433"/>
        <property type="gene ID" value="HS99_0021240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="32413" checksum="669D17533CE86909" modified="2017-01-18" version="1">MRTLKAVALTAAALVSVGAATTTARADSGSDVPDYGAARQVLRSGQTHDTVSRFLGAARTAVSPGGGPGTGTGADGGSAGGRPNTPNAVAAPPSFELKDPVPMYELSVDFVTGKAQPTPQNALRLSYLASRVSAADGHQAAVLLAPPGNGGGWRLAGIRDGDNELTLAERATAGARTFTEPQIHAWYRLTASADVEPLNTEATTGLGGKQSLPLAAYQKLVTGRYADKLPGSGYDRNGLAGGFGLFDGTGSAAGPTAGSAAGTPPQAQPEARAGTQTPTTSSDSASAEQSPPPSWQLPALGAAVLAAGAAGFGLRRRRRAAATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND73</accession>
    <name>A0A1E7ND73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-6Y methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0020245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281215.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene630"/>
    <dbReference type="EnsemblBacteria" id="ARF77625">
        <property type="protein sequence ID" value="ARF77625"/>
        <property type="gene ID" value="B6264_00660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38598">
        <property type="protein sequence ID" value="OEV38598"/>
        <property type="gene ID" value="HS99_0020245"/>
    </dbReference>
    <dbReference type="OMA" id="MPVTQWS"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="43073" checksum="CEF6F1F826EA4C72" modified="2017-01-18" version="1">MPELPPPITVVGIGADGWSGLAAGSRAALQSAEVVIGGPRQLALLPHGEVGAERVAWPSPLRPALPGLLADHAGRRLAVLASGDPMFFGIGRTLAETVGADRLRVLPHPSSVSYACARLGWPLEATEVVSLVGRPLDTLTLALHPGRRLLVLSADAATPAAVAALLTERGFGAARLHVLEQLGSPDERRLDGRADDWPHPPGNPLNLIAVELGDGPRGSLVPGLPDAAYESDGQLTKRHVRAATLAVLAPSPGELLWDVGGGSGSIAVEWLRAHRDCRAVSIERDPLRAERIARNAASLGVPRLRVVTGPAPAALVELPTPDAVFIGGGLTAPGLLDRCWAALRPGGRLVANTVTLESEALLTEWYRRHGGELVKLAVAHAVPVGGFTGWRQAMPVTQWSAVKPNTPQENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDA1</accession>
    <name>A0A1E7NDA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xanthine dehydrogenase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000247.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1775"/>
    <dbReference type="EnsemblBacteria" id="ARF77688">
        <property type="protein sequence ID" value="ARF77688"/>
        <property type="gene ID" value="B6264_01025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38655">
        <property type="protein sequence ID" value="OEV38655"/>
        <property type="gene ID" value="HS99_0020610"/>
    </dbReference>
    <dbReference type="OMA" id="VMGRAQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017609">
        <property type="entry name" value="Xanthine_dehydrogenase_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03196">
        <property type="entry name" value="pucD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="788" mass="84589" checksum="9783815D4B30F719" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL5</accession>
    <name>A0A1E7NDL5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name evidence="2" type="ORF">HS99_0018950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286356.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7341"/>
    <dbReference type="EnsemblBacteria" id="ARF81163">
        <property type="protein sequence ID" value="ARF81163"/>
        <property type="gene ID" value="B6264_21680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38754">
        <property type="protein sequence ID" value="OEV38754"/>
        <property type="gene ID" value="HS99_0018950"/>
    </dbReference>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0742">SOS response</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="38022" checksum="3F559D9B51E102AB" modified="2017-01-18" version="1">MYEEPADRLVTAAADGEDQAVEAALRPKLLDEFIGQERVREQLSLVLQAARKRGSAPDHVLLSGPPGLGKTTLSMIIAAELGAPIRITSGPAIQHAGDLAAILSSLTEGEVLFLDEIHRMSRPAEEMLYMAMEDFRVDVIVGKGPGATAIPLELPPFTLVGATTRAGLLPPPLRDRFGFTGHMEFYAPTELQRVVHRSATLLDVEIDPAGAAEIAGRSRGTPRIANRLLRRVRDYAQVRHDGVVTAEIAGQALDVYEVDARGLDRLDRAVLDALLRLFGGGPVGLSTLAVAVGEEAETVEEVAEPFLVREGLLARTPRGRIATAAAWQHLGMTPPVQTTRGSVPPQPELFPADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED4</accession>
    <name>A0A1E7NED4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557381.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000632.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4373"/>
    <dbReference type="EnsemblBacteria" id="ARF83235">
        <property type="protein sequence ID" value="ARF83235"/>
        <property type="gene ID" value="B6264_30310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39005">
        <property type="protein sequence ID" value="OEV39005"/>
        <property type="gene ID" value="HS99_0018040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6617" checksum="74B2F603DF008E4D" modified="2017-01-18" version="1">MIVTASLTAVLGIVVVVLYRFGRLRILPSLTVGAFGFSLATTGAAPTIQAFLGGAVHLLASIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED7</accession>
    <name>A0A1E7NED7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557113.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39071">
        <property type="protein sequence ID" value="OEV39071"/>
        <property type="gene ID" value="HS99_0018430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="13152" checksum="8F256CE80419611A" modified="2017-01-18" version="1">MDPFYLFEDAPSPYAFFGTNPTLFDAPSRDERASLDWTAHSYLAWTPMDDSERRVVPLAGFSWGFTIDSTGSIALQEVQALGAVNWDEHLTYLRSSHPRWLFDKWQPAQEDPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG6</accession>
    <name>A0A1E7NEG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosysynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6519"/>
    <dbReference type="EnsemblBacteria" id="OEV38883">
        <property type="protein sequence ID" value="OEV38883"/>
        <property type="gene ID" value="HS99_0019700"/>
    </dbReference>
    <dbReference type="OMA" id="TQPNLRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="18511" checksum="4DB18FCEC38073D4" modified="2017-01-18" version="1">MVAVSSNAEYSFSKPNRTGITLLAGLGVEGDVHAGVTVRHRSRVAQDPTVPNLRQVHLIHRELLAELAESGFDVAPGALGENITTEGVDLLGLPVGAVLRIGPEAEVEVTGLRNPCVQIENYRAGLLKQVVGRAEDGTLVRRAGIMGVVRAGGPVRPGDAITVVLPEGPHRALDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH9</accession>
    <name>A0A1E7NEH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557117.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83307">
        <property type="protein sequence ID" value="ARF83307"/>
        <property type="gene ID" value="B6264_30735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39074">
        <property type="protein sequence ID" value="OEV39074"/>
        <property type="gene ID" value="HS99_0018445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="19184" checksum="B38F9B0C331DF00F" modified="2017-01-18" version="1">MPIDDFDAWRSELLATGNIVQDADDSVPQPEAERRFHRYRELADLVDGTEGPKAVAALVSSMQARHDYGAYQATHSALSRFPLAELARGMILAAPALVAMSRDRAGEVLLPVALAETAIVEDFTHAAADLDQQMRDELAAVIASQEEEGGWFDRPRARGRLRVGPFEATLADELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEM6</accession>
    <name>A0A1E7NEM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558254.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83166">
        <property type="protein sequence ID" value="ARF83166"/>
        <property type="gene ID" value="B6264_29920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38943">
        <property type="protein sequence ID" value="OEV38943"/>
        <property type="gene ID" value="HS99_0017665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="616" mass="64966" checksum="5E64D99035B8CB7F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU9</accession>
    <name>A0A1E7NEU9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480293.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3550"/>
    <dbReference type="EnsemblBacteria" id="OEV39230">
        <property type="protein sequence ID" value="OEV39230"/>
        <property type="gene ID" value="HS99_0000435"/>
    </dbReference>
    <dbReference type="OMA" id="PMLWVSN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31023" checksum="DC9D8E5133625CF3" modified="2017-01-18" version="1">MSVWLPTAPCRPDTCLGERTPEVSQPRRALRLTACLVAVLVGVLLSLPVRLLPYGTRDRLIRLWARVLLRTLGVTVNLGTTGTTGTAGTARAGGASDGGAAVGGSAVGAGAVGADGALVVANHVSWLDIPLLAAGRPGRSLAKTEVRKWPVLGPLVAWGGTVFLDRDRLRTLPDTVAAVTEVLRSGHPVIVFPEGSTWCGRESGRFRPALFQAAVEAGAFVQPVTIRYRLADGRPTSAPAFIGDDGLLTSLARVVAVRGLVADVTFLPPIPPPGPQPTRAGARRELARAAQAAVEGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW6</accession>
    <name>A0A1E7NEW6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3291 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285148.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000490.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39188">
        <property type="protein sequence ID" value="OEV39188"/>
        <property type="gene ID" value="HS99_0000185"/>
    </dbReference>
    <dbReference type="OMA" id="HAFTFHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021708">
        <property type="entry name" value="DUF3291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11695">
        <property type="entry name" value="DUF3291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3291" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20512" checksum="F5FBB1EEC47D869C" modified="2017-01-18" version="1">MPHLALYTFGTLKSPLVDPAPLTEEFYDVGATVYQEISRHPGYLAHAEAADGERGVFFEADWGAWGEFAVPAWYSKGRTRETTALAATLSLWTGLSPAVDAIYTGLHRRALTRRHDWVERTEYPNYVTWWVSEGAIPAWRDGVSRLEHLHDHGAAPHAFTFHHSFAPDGTAARAGSVGPKSDPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF02</accession>
    <name>A0A1E7NF02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284967.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000713.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3617"/>
    <dbReference type="EnsemblBacteria" id="OEV39280">
        <property type="protein sequence ID" value="OEV39280"/>
        <property type="gene ID" value="HS99_0000760"/>
    </dbReference>
    <dbReference type="OMA" id="GADITTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="40603" checksum="32CA4EDC5254A21D" modified="2017-01-18" version="1">MDLAFLTPLLDRPGPWASLYLDTSRATEDAAPRRALIDRAAVHRLAGLGADDATCAAVRDHLAGEPTAASPPGRALFAADGEVALDVPLTDSPPDVAATWAPLPHTAPLLGLLDDAAPRCLVVAVDRTGAALEQHELGRSAPIGTVEGRQWQGRGHRAPPADRYEWHYRHRVEDAWERTATIVADQLTRMWPGSGAGLLVLTGDVRERRAVRAKLPPQLQSDTVEVDGGGRADGIARDSFERRVAEAWEEHRSRHLTTVLDAFRTGVGRPGEHATDAAGTETAPGAAAQGVPAVVTAARQHQLAALLIQPGGHDAERPVWTGPEPEHIGVQRADLRSMGVARPQQAPAADALLRSAAAVGAEALLVPEAVPGPPGGLGAVLRWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA1</accession>
    <name>A0A1E7NFA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000596.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1521"/>
    <dbReference type="EnsemblBacteria" id="OEV39352">
        <property type="protein sequence ID" value="OEV39352"/>
        <property type="gene ID" value="HS99_0001165"/>
    </dbReference>
    <dbReference type="OMA" id="CIGHPWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="508" mass="53718" checksum="329D1E0D4461A48B" modified="2017-01-18" version="1">MQARKIGAAAATAVALLAARDLVQKKHALLRNFPVLGHARYLLETIGPELRQYIVTSNEEERPFSRDQRTWIYASAKEENNYFGFGTEVDVEHVQGHAYVKQRTFAGALPDIHDPQAPLPSAKVLGGPRGRAEAFRPASVVNISAMSFGSLSGAAITALNKGAAEAGAMHNTGEGGLSPHHRQGGDLVLQLGTAYFGCRNEDGSFNLDKLKEVVAGAPVRAIEIKLSQGAKPGLGGMLPGAKVTPEIAAIRGIPVGQDCASPSRHTAFGDVDSMLDFVELLATETGLPVGVKSAVGDMGFWQELAALMERRDRGVDFVTIDGGEGGTGAAPRMFADSVSLPFRMGFSRVYGTFAERGLTDDLTFIGSGKLGLPENAAVAFALGVDMINVAREAMLSIGCIQAQKCHTDKCPTGIATQNPWLARGLDPASKSTRAAVYLRTLRKELLKVSSAVGVAHPGLITANDIEIMNGDYEARTLAGVYGYKEGWGELGPRLAKEITALLTPGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF6</accession>
    <name>A0A1E7NFF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557675.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7528"/>
    <dbReference type="EnsemblBacteria" id="OEV39417">
        <property type="protein sequence ID" value="OEV39417"/>
        <property type="gene ID" value="HS99_0001580"/>
    </dbReference>
    <dbReference type="OMA" id="CHCEGCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26532" checksum="EFD21E42FE651D98" modified="2017-01-18" version="1">MSNARVRRAEAYWPPSGLLGRVDEADRRVLLGLGHGVVYPAGQITIHEADTSDFALLLVGGTVKVTAHAQDGREALVAVRMAGDLVGELAGIDGQPRSGTVTTCGRVLARYILSSELLECTKQHPAIGLALSASVVAKLRTATGRIVDFTGCDVLGRLARILHHLAVTYGRPGRNEAQLPLSQPEMATLVGAAESSIHKALRALRESGAVITGYRRITILDLDHLARIAVTAEEAGASVASGAADSRAIPPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFN9</accession>
    <name>A0A1E7NFN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3644"/>
    <dbReference type="EnsemblBacteria" id="OEV39303">
        <property type="protein sequence ID" value="OEV39303"/>
        <property type="gene ID" value="HS99_0000895"/>
    </dbReference>
    <dbReference type="OMA" id="PIWVHTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="27695" checksum="DA4D45A65A39AC97" modified="2017-01-18" version="1">MIIDAHSHVHDPLDSHLALLDEAGVDRAVLFGTRPHPERAVDLASFKREMDVLHATVSGRSAGAEAHEAAVRELAAACAAHPDRFIGFGKVRLDVPAERIAAEVERDVVARGFRGIGELTPPPDGAGLIEPVLRASADHGGLPVVVHGFAPTTAGDLATLAGLARRHPSVPVVISQLGGLNWLTAIELARETPNLYLELSTTNVVFALRLALREVPDRTVFGSDAPYGDPVLTRALVERVTSPGELRDRVLGGTFAELIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG96</accession>
    <name>A0A1E7NG96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556219.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000456.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5046"/>
    <dbReference type="EnsemblBacteria" id="OEV39513">
        <property type="protein sequence ID" value="OEV39513"/>
        <property type="gene ID" value="HS99_0002145"/>
    </dbReference>
    <dbReference type="OMA" id="VIALEMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="45689" checksum="0C5FC7912E0F5872" modified="2017-01-18" version="1">MSLRSPRSGRASGGALRRHRGLALLFVLPALLLLGALVVYPIGYSVARSLFDASGHRFVGLDNYGTAFTDHATLTAVRNNAIWVAVAPALVTAVGLVFAVLTEKIRWATAFKLLVFMPMAISFLAAGIIFRTVYDADPHRGALNAAAVAVHDTFNDRSTYPGAHPRPGGGLDRAQGGDITAPTSTRVVLLPLVGVQPGALPATARTAQEPAGGDGVSGTVFLDFVPGGGGHPGRLDAGKKGLPGVTVQLRDGGRTVDTTTTAADGTFRFGAAPTATTSVVMPAANFAAPYRGVDWLGPAFITPAIIGAYIWIWAGFAMVIIAGGLANLPRETIEAARIDGAGEWQIFRRITVPQLAPVLGVVFITMVINVMKIFDLVYIIAPGPVQQDAGVLALRLYLVSFGGGNDQGLGSALSVLLLLLVVPVMLLNVRRFRGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL6</accession>
    <name>A0A1E7NGL6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386896.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000558.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1529"/>
    <dbReference type="EnsemblBacteria" id="OEV39812">
        <property type="protein sequence ID" value="OEV39812"/>
        <property type="gene ID" value="HS99_0001210"/>
    </dbReference>
    <dbReference type="OMA" id="QIVGSTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16466" checksum="490B394B884B41B2" modified="2017-01-18" version="1">MAQDPAQLIPELAEVSAALFKVVGNRSIPRTTIGLVQLRAGQIVGSTYLTVLHTAFLRKAGESEERITSVAGWQDSPYLTAPERAALALVEAVLQPNPHGERVSDELYALAAEHYDEKALATLMTAIGQVNFFVAIALIAKPVPGRSFSEPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUY4</accession>
    <name>A0A1E7MUY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000101">
        <property type="protein sequence ID" value="OEV32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000696.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000123_gene6317"/>
    <dbReference type="EnsemblBacteria" id="ARF77565">
        <property type="protein sequence ID" value="ARF77565"/>
        <property type="gene ID" value="B6264_00255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32245">
        <property type="protein sequence ID" value="OEV32245"/>
        <property type="gene ID" value="HS99_0040325"/>
    </dbReference>
    <dbReference type="OMA" id="QRAYPVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="27888" checksum="2A1064EC61781372" modified="2017-01-18" version="1">MAEFVYPPVIGAALTAFRALDVRIKIIGAEHIPATGGAVLVSNHISYLDFLFAGLGAYRGGKRKTRFMAKDDVFRHRISGPLMRGMKHIPVDRTDGQPAYEAAVRALKAGEVVGVFPEATISRSFMLKKFKTGAARMAADSGAPLLPVVLWGTQQLWTKGRPKTLTKRHIPVTIMIGEPIHLGPNDKPVMVTRKLRAAMTEMLDRAQREYPGKPSGPDDTWWLPAQLGGTAPTLEVAEAEDEAEALAKAERRAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV84</accession>
    <name>A0A1E7MV84_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289638.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000184.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6926"/>
    <dbReference type="EnsemblBacteria" id="OEV32337">
        <property type="protein sequence ID" value="OEV32337"/>
        <property type="gene ID" value="HS99_0016685"/>
    </dbReference>
    <dbReference type="OMA" id="NQIIQWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="17637" checksum="CE0AD06E210C88B5" modified="2017-01-18" version="1">MSMVKESVDVDVPLHAAYNQWTLFEEFPRFMEGVDAVTQLDDRHNHWRTSIGGVSREFDTEIVDQLPDERIAWRTMDGGDVDQKGVVTFQKLDDLHTRVNMAIDFRPEGMAEKTADVLGVVDRRVKGDLRRFKEFIEERGRAEGGWRGRITPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV95</accession>
    <name>A0A1E7MV95_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 10">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0016745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 10"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6937"/>
    <dbReference type="EnsemblBacteria" id="OEV32349">
        <property type="protein sequence ID" value="OEV32349"/>
        <property type="gene ID" value="HS99_0016745"/>
    </dbReference>
    <dbReference type="OMA" id="YGCPDAG"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Homoserine_dh" evidence="12">
        <location>
            <begin position="161"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="34583" checksum="531CFA3F09CBC7C5" modified="2017-01-18" version="1">MSSPHAGSDPAVVLSGYGPVGRAYAERLLTRGEGLARDHGVRPRLAAVRVGTAQVLLPDGGPVPPRAEWAPPAELEETLDRTGARVLVQALPSSPKARQQAAEEAVLALGRGVHVVTATKSHLLSHWSELGEAARSGGSLIRISGATGAALPAADLARTGVRGLGCRSLRACPNGTATFVLDRLAAGDSLDRAVGEARCRGIAEADPTADLSGGDAATKVRLLAALLWGWEPSAVRVGTEAVDARTGPAAVAAAVRGNRLRAVASASADRPFVVEVRLEETVPGDPLHALTGPEKAVVYGCPDAGDITVSGGRSSPLGAALAMLRDTLDVTAPRGYGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM4</accession>
    <name>A0A1E7MVM4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">HS99_0017560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000691.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1235"/>
    <dbReference type="EnsemblBacteria" id="OEV32486">
        <property type="protein sequence ID" value="OEV32486"/>
        <property type="gene ID" value="HS99_0017560"/>
    </dbReference>
    <dbReference type="OMA" id="ECLRSAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8549" checksum="3C1BD4FE3888E6B2" modified="2017-01-18" version="1">MTKTTNGIEVEGTVVECLRNANFKVELPNGHVVLAHISGKVRRNHIKILPHDRVLVELSPYDLTRGRIRFRYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW2</accession>
    <name>A0A1E7MVW2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0040085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8132"/>
    <dbReference type="EnsemblBacteria" id="OEV32566">
        <property type="protein sequence ID" value="OEV32566"/>
        <property type="gene ID" value="HS99_0040085"/>
    </dbReference>
    <dbReference type="OMA" id="TRQEPPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="488" mass="50310" checksum="2FB7A40904F63FBB" modified="2017-01-18" version="1">MDGLFTYCLSVLCEHDAATAALHEVRELARRHGARLAEPGLVRAWLFSLARYCCLRRLADGTVGEAGSGTEPGAGPGAELTEAEAVRRRRELASLAWPEAAGTDPEQREALELSVRHRLTPLEVAAVLGLPFDRTRGLLAAAEAEVARTRAALLVLGVGSCPELDRLGGAGTESWRDWVLGPALRRELVQHVVDCPTCRGTAERVAAGEAAEGAAGLSGLPLLTAPSPAGGDASGAARRVGGVASGAAAGAAWVSAAGAAGLRFDHGGFPRHRVPDAGRGLAVRRRVVTTGVLAAVLAAPVVALWAGHRGGAGPGSAASVSAVRVDEAGRDTGQRPPWAVGGAGADAAGGRGCRGWSWRVRVPGVGASRVARVARVARAVQKRCFPAFRGSPSRDRWSRYRAEVRPRSAAPPWSPPRPPWSNGPPLRARATRPRPGCSPSRPASTAAGRCSPSPTPVPRRSAGTPRRTPDGSGSAATRGPWSPGSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW12</accession>
    <name>A0A1E7MW12_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738012.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000432.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3841"/>
    <dbReference type="EnsemblBacteria" id="OEV32622">
        <property type="protein sequence ID" value="OEV32622"/>
        <property type="gene ID" value="HS99_0015205"/>
    </dbReference>
    <dbReference type="OMA" id="THCEKSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28235" checksum="BACF6F1371D8A979" modified="2017-01-18" version="1">MGIMNATDFAVELRSVRRTYRRGPEPVVGLDGVSVGFPFGTFTAVMGPSGSGKSTLLRSAAGLEAIDDGEVRVDGTVLGGLRDKELTVLRRERIGFVFQSFNLLPALTAAQNVALPAKLSGRRPAPAEVTAALAAVGLADRAGHRPGELSGGQQQRVAIARALITRPAVLLADEPTGALDTRSGREVLALLRGMADDPGRAVVMVTHDPVAAAYADRVLFLRDGRLDGSLERPTAEQVAARMTALEAHAPEAHPSKAHPSQAHASEASAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA0</accession>
    <name>A0A1E7MWA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557658.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7852"/>
    <dbReference type="EnsemblBacteria" id="ARF78243">
        <property type="protein sequence ID" value="ARF78243"/>
        <property type="gene ID" value="B6264_04315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32717">
        <property type="protein sequence ID" value="OEV32717"/>
        <property type="gene ID" value="HS99_0015770"/>
    </dbReference>
    <dbReference type="OMA" id="GTPCKDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33576" checksum="4D647B6AE7221E46" modified="2017-01-18" version="1">MRRFPSRLAVAGAAVVLTAGLIAPTAAQAAARPATRAGTLKWAALGDSYTAGIIEATGALTAPQDGCARTTGSYPELIRRDLGSGADLRNVSCSGAATPDVYANKQSPNGRPLPPLGTDPNAPYPPVPPQVDAVDPDTQVITVGIGGNDLGFAEILKDCIELGAARLGLGTPCKDKYDAQLPGRLDRLRTGYNAMLGALQTKAPSARIYTVGYPHLIPENARLCRYGSLLQFATFTAGDLAWARTRILEPLNLVVEQATSAQQDTYVDLYADSAGHSVCDGDHWLDGVLTSVVPLKYAVVHPNARGQAFAATQVENTVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA4</accession>
    <name>A0A1E7MWA4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557662.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000836.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7858"/>
    <dbReference type="EnsemblBacteria" id="ARF78249">
        <property type="protein sequence ID" value="ARF78249"/>
        <property type="gene ID" value="B6264_04345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32711">
        <property type="protein sequence ID" value="OEV32711"/>
        <property type="gene ID" value="HS99_0015740"/>
    </dbReference>
    <dbReference type="OMA" id="MWWSTYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="44867" checksum="1DAE97DDC5C3C60B" modified="2017-01-18" version="1">MSTTRTSGKKALVIGGGIAGPVMALALRRAGIEAEVFEAYETSAEGIGGTFMIAPNGLGALAVVGLEAEVGRIGQPVGPMVIEDGKGGVLVEFAGLPDLPRGRLMRRAEMYEVLQRRLRETGLEVRHGKRLVGAEETADGITAHFADGTSATGDLLIGTDGTGSTVRTLIDPAAPAARYTGLLGVGGYSPYRLPGRAGRGETVHFANGARAFFGYWGLADGSGTAWFSNIPQPEQLSYEQVRAVSPEDWLRRCRELHADDLPAREVLRVADAGTVETFPRLEIMPSVPHWHRGRMVLVGDSVHAPSNSSGQGVSLAVESAVELARCLRDLPDHTEAFAAYEAMRRPRVEKIAADAERTNNQKASGPVGRMVFRLVAPIMMRTFMSPEKMLRPVHGYRIDWERRVAPVTPVRRAGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE0</accession>
    <name>A0A1E7MWE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386731.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7807"/>
    <dbReference type="EnsemblBacteria" id="ARF78200">
        <property type="protein sequence ID" value="ARF78200"/>
        <property type="gene ID" value="B6264_04075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32755">
        <property type="protein sequence ID" value="OEV32755"/>
        <property type="gene ID" value="HS99_0016005"/>
    </dbReference>
    <dbReference type="OMA" id="SNHARTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="22196" checksum="4326EB700C0DC925" modified="2017-01-18" version="1">MIGPMTAPLTPPRPTLIADAAIDLIADAGLRGLTHRAVDDASGLPAGSTSNLARTRAALLELVLVRILERETADHPAFAEGGGLSATTLPPRDLLVEVGAEALFQALTSGRRLTLARLELALEATRRPELRSVYDRLGARFTRFAADLLAASGSTDPEVDARRLIRWCDGVLFNATAGSGHWQVPMPEELRVDLDRYLAALLEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY2</accession>
    <name>A0A1E7MWY2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366908.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5774"/>
    <dbReference type="EnsemblBacteria" id="OEV32940">
        <property type="protein sequence ID" value="OEV32940"/>
        <property type="gene ID" value="HS99_0013730"/>
    </dbReference>
    <dbReference type="OMA" id="ERDHITI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15351" checksum="F3D47011529F8955" modified="2017-01-18" version="1">MEHLVSHRIKRQAVLYREQPIPLSAVVHETALRMGFGGPDVVRDQLEYLLTVSEYPHIDLRVIPFGTGSFPSSGAGVVYFAAEVARLDSVQVDGDRFEFIDTEPQLIKHRAVLDRLEASALKPDASRDLIRRIAQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX37</accession>
    <name>A0A1E7MX37_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279912.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5728"/>
    <dbReference type="EnsemblBacteria" id="ARF81393">
        <property type="protein sequence ID" value="ARF81393"/>
        <property type="gene ID" value="B6264_22990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32979">
        <property type="protein sequence ID" value="OEV32979"/>
        <property type="gene ID" value="HS99_0013960"/>
    </dbReference>
    <dbReference type="OMA" id="ELASHDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15061" checksum="86CE1B80AC2E1FFB" modified="2017-01-18" version="1">MSDLLERLRERGWRLTSQRRVVAEVLDGEHVHLTADEVHARAADRLPEISRATVYNTLGELVTLGEVIEVSTDGRAKRYDPNAHRPHQHLVCTGCGAIRDVHPVGNPLADLPAEQRFGFTLSGAEVTYRGLCPACAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH0</accession>
    <name>A0A1E7MXH0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0013980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5724"/>
    <dbReference type="EnsemblBacteria" id="OEV33150">
        <property type="protein sequence ID" value="OEV33150"/>
        <property type="gene ID" value="HS99_0013980"/>
    </dbReference>
    <dbReference type="OMA" id="PRNDGMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="20327" checksum="7FF456F864F54BC0" modified="2017-01-18" version="1">MQTNELLTDAATFPSGTAPEPDTWFVKLKPGTDHAAYATARGGALAPLHLAAAAGAEHGSSDSITALNSLTATLTVLLVVVAGLGVFNTVVLEIRERTRDMGVTKAVGMTPAQTAGVVLASVLLVGAVGGAIGLPVGLLLHGLTVPAMAHSAGLNFPSSALDVFGTPTLILLGLGGVLIALLGALLPAVRATRARTVDALRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXV3</accession>
    <name>A0A1E7MXV3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HS99_0039175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290885.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000834.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5918"/>
    <dbReference type="EnsemblBacteria" id="ARF82080">
        <property type="protein sequence ID" value="ARF82080"/>
        <property type="gene ID" value="B6264_27225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33241">
        <property type="protein sequence ID" value="OEV33241"/>
        <property type="gene ID" value="HS99_0039175"/>
    </dbReference>
    <dbReference type="OMA" id="CNAEWAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="438"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OEV33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="556" mass="57359" checksum="9101B065D552CA5B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY40</accession>
    <name>A0A1E7MY40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283894.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3398"/>
    <dbReference type="EnsemblBacteria" id="ARF80447">
        <property type="protein sequence ID" value="ARF80447"/>
        <property type="gene ID" value="B6264_17405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33346">
        <property type="protein sequence ID" value="OEV33346"/>
        <property type="gene ID" value="HS99_0012175"/>
    </dbReference>
    <dbReference type="OMA" id="RGEIVMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20509" checksum="F82783521BC4CF80" modified="2017-01-18" version="1">MTAIDDRMTGIFENLEVPEGVKAELIRGEIVMMAGPDMVRNLIVSAIQHQTPYARWRALQTQDLIISGEASEPQPDLVVFERGVVPEAGRLLSASAVTLVVEVVSKTSVHRDYRIKREMYAQGGIPAYLIVDPLKGVCVLLTDLTTDTPSGLPVYWSERTTKFGDPIRVDLLDITLDTSEFQTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY72</accession>
    <name>A0A1E7MY72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287644.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80485">
        <property type="protein sequence ID" value="ARF80485"/>
        <property type="gene ID" value="B6264_17610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33382">
        <property type="protein sequence ID" value="OEV33382"/>
        <property type="gene ID" value="HS99_0012385"/>
    </dbReference>
    <dbReference type="OMA" id="GVSTTWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="32728" checksum="F640D2DC977A761E" modified="2017-01-18" version="1">MTPAAQARPAVAGPHRGTPDEARRHDLAAFLRSRRERIAPEQVGLPMTGRRRTPGLRREEVAQLAAVGVTWYTWLEQGRDIQVSAQVLDAVARALLLDPSERAHLFTLAGAEDPAPVTECPSVTPSVRLVLDQLAPYPAAVVNSRYDILAHNAPYSALVGDLRELPVEERNLMWLAFTPSRFREVLIDYRTERIGMVARFRAAMADHSAEPAWKALLARLRKASPDFEEEWQRHEVMGPGNGIKRFLVPGVGLLRCSYTNFWLGPRLGTRLISYTPLDDETRVLMDELPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY76</accession>
    <name>A0A1E7MY76_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553459.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4006"/>
    <dbReference type="EnsemblBacteria" id="ARF80489">
        <property type="protein sequence ID" value="ARF80489"/>
        <property type="gene ID" value="B6264_17630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33386">
        <property type="protein sequence ID" value="OEV33386"/>
        <property type="gene ID" value="HS99_0012405"/>
    </dbReference>
    <dbReference type="OMA" id="QWPEVAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23273" checksum="881CC17B5049BF18" modified="2017-01-18" version="1">MRAVIAEDSVLLRVGLVKVLEAVGFEVVAAVGDADELLAAVEEHRPDVVVADVRMPPGFHDEGVKAAMVIRRQWPEVAVLLLSQFVEERYAADLLATNTSGVGYLLKQRVANVDDFLDALQRVAEGGTALDPEVVAQLLVRRKQDPLEKLTPRERDVLALMAEGRSNAAIAAALVVSDSAVAKHINSIFTKLDLPPADDNHRRVMAVLRFLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC1</accession>
    <name>A0A1E7MYC1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6575"/>
    <dbReference type="EnsemblBacteria" id="ARF80544">
        <property type="protein sequence ID" value="ARF80544"/>
        <property type="gene ID" value="B6264_17980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33440">
        <property type="protein sequence ID" value="OEV33440"/>
        <property type="gene ID" value="HS99_0012755"/>
    </dbReference>
    <dbReference type="OMA" id="MGEYASS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15493" checksum="14804E740B4EB016" modified="2017-01-18" version="1">MDKQEAEQALASAEVLASRMRRGARSHVVGVVLLGLAMMVSTAVYGLLIQPSTRYSMPFGLLFPLLFLGIYTATRPVVPRHHRARYAVITSAGAGIYSLTVLIGTVKFSGEPLWWLPGAVLCALPFFLVALLDHRAKPAGSGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE4</accession>
    <name>A0A1E7MYE4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA alkylation response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0012895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555541.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6604"/>
    <dbReference type="EnsemblBacteria" id="ARF80568">
        <property type="protein sequence ID" value="ARF80568"/>
        <property type="gene ID" value="B6264_18115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33465">
        <property type="protein sequence ID" value="OEV33465"/>
        <property type="gene ID" value="HS99_0012895"/>
    </dbReference>
    <dbReference type="OMA" id="GNVQCLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="544" mass="58615" checksum="6FBA0553049EB371" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYN6</accession>
    <name>A0A1E7MYN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549960.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000229.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5230"/>
    <dbReference type="EnsemblBacteria" id="OEV33547">
        <property type="protein sequence ID" value="OEV33547"/>
        <property type="gene ID" value="HS99_0013405"/>
    </dbReference>
    <dbReference type="OMA" id="MANCHRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="45079" checksum="B2AEE142494F69E5" modified="2017-01-18" version="1">MTESLTVLIPAHNEADFIADAVKSAFGQTVRPRTVLVLADSCTDDTAAIARRCGAEVLEVDCRSKPESLNLALAEVTTEFVALLDADGYFASDRALEMCLERMRAKGYGGVCMSVTPHSVKGVFQRSRVIEWAAAHRMSRTVESWHGWVAVLSGCAGVYRTESVRAVGGWSADSLCEDVELALKMNRAGHKAGFVPGAYVCVRDPGSWSVYWAQTHRWAAGWAQALYQHRSLFLHSWGFTRVFGAMLVDSVLMASGYLSLLYQLATRFTHFDAFRWMGLWFLMMVALTFGTAALQIGIRRTLTCYPAYLVVGTMGTVVSLWVMFREWVLGRHLISWTGRQGRQVEITRMSERRRFVLALTGAGAGLVGALSGRVLDREYLFLTGAAATGSVLLSALLWHLVNRMPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP2</accession>
    <name>A0A1E7MYP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5246"/>
    <dbReference type="EnsemblBacteria" id="ARF80665">
        <property type="protein sequence ID" value="ARF80665"/>
        <property type="gene ID" value="B6264_18705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33560">
        <property type="protein sequence ID" value="OEV33560"/>
        <property type="gene ID" value="HS99_0013485"/>
    </dbReference>
    <dbReference type="OMA" id="THPDPYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="43130" checksum="03B865E857BEB9F6" modified="2017-01-18" version="1">MDGAAIIEQLMTTEVRTDPYPLYARAHELGPVLPAGDGMFVVSGYAAVNKVLRTSAFGVATADMMAGLAPEFSEHSSLALFGRSILQRNAPDQPRVRSLIASVFTARRVAALRPAVEAAVGRLLDGMAEQGADGSPVDFMDAFAFRLPVGVICELLGVPERDRYRFRGLASDLTVALEIVQDLDDLDEADRAADELSGYFTELVAERLARPQDDLVSDLARIAADGGGRLSGQELLANLVLLLVAGFETTTNLLGNGLALLFRHPEAAAGLRSGTLSPAGFTDEVLRFDSPVQATGRVALAEGLSIEGLPVPADSGLTLLIGAANHDPARYERPGVFDPTRTDSQPLSFGGGTHFCLGSQLARMEAEVAVPALLDRFPRLARGGVPTRRDRLVLRGYETLPVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ45</accession>
    <name>A0A1E7MZ45_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385696.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1944"/>
    <dbReference type="EnsemblBacteria" id="ARF79605">
        <property type="protein sequence ID" value="ARF79605"/>
        <property type="gene ID" value="B6264_12380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33704">
        <property type="protein sequence ID" value="OEV33704"/>
        <property type="gene ID" value="HS99_0038125"/>
    </dbReference>
    <dbReference type="OMA" id="ERHHAGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="35613" checksum="0C458409A3B32157" modified="2017-01-18" version="1">MFRTDPETPDVFRTPVDEVFVRSHLGRHPQFDPAGWTLTVEGLVERPLRLDFRDLRGLPQTGFTAVHECFGNPRHPTVPTRAVTNLEWAGVPLAEVLALAGPRPEARHVWLEGADRGDFAGESDVSYLKDLPLEEARAEVVLAHTMNGEPLRPDHGHPVRAVAPRMFGTNSVKWLTRIVLAAERPEHLFTTRLYTRVLPGESESRPVREKDVSSKLLTPGDGRSVPAGDCELAGYAWSSTEVTAVEVAVDDADWQPAELDRRGPGFGWQRFRLRHDLAPGPHRIRCRATDSAGRVQPLTGDRNAVHEIRVTAEVSGRPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG6</accession>
    <name>A0A1E7MZG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289887.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000878.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4310"/>
    <dbReference type="EnsemblBacteria" id="ARF80335">
        <property type="protein sequence ID" value="ARF80335"/>
        <property type="gene ID" value="B6264_16735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33826">
        <property type="protein sequence ID" value="OEV33826"/>
        <property type="gene ID" value="HS99_0037435"/>
    </dbReference>
    <dbReference type="OMA" id="MYVGALE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10954" checksum="A01C02658D629A35" modified="2017-01-18" version="1">MFVGTLTFDLLLGDVHSLKEKRSIVRPIVAELQRKYSVCAAETGNQDLHRRAEIGLAVVSGEAGYVTEVLDSCERLVAGRPEVQLLSARRRYHNDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP1</accession>
    <name>A0A1E7MZP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552232.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1837"/>
    <dbReference type="EnsemblBacteria" id="ARF77747">
        <property type="protein sequence ID" value="ARF77747"/>
        <property type="gene ID" value="B6264_01335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33904">
        <property type="protein sequence ID" value="OEV33904"/>
        <property type="gene ID" value="HS99_0010495"/>
    </dbReference>
    <dbReference type="OMA" id="YDITHTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="311" mass="34541" checksum="65C0F03749CE678E" modified="2017-01-18" version="1">MTDTQVLTVAQRLGTRALAWLHAHYTDGRGRLTDSTVIDLADPDDVYKPLCETALAASLVLREGVAGPRDTRAARELLETAWAQLRGGDLLYDRQLRHVAITDPLETYAHFARAGYRHAALEELLNSLGRLRAVHALEMQGSRRLALANAWRIAGLEHRPDWPALARATWLGARPEPWTITWVIGYQVTHTVFHLTDWGSRPDCLPEPMRDYLRDWLPVWLDVWLETGEWDLVGELLIVDSCIGEPVTGRTGWEALAALQHPDGLIPRDAVTPVHEDPEDTFREHEHTAVVGVVAATVALSRALGGTPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU5</accession>
    <name>A0A1E7MZU5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydropyrimidinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280313.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2175"/>
    <dbReference type="EnsemblBacteria" id="ARF77807">
        <property type="protein sequence ID" value="ARF77807"/>
        <property type="gene ID" value="B6264_01690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33954">
        <property type="protein sequence ID" value="OEV33954"/>
        <property type="gene ID" value="HS99_0010850"/>
    </dbReference>
    <dbReference type="OMA" id="SAETHHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="51130" checksum="5AB0FC02BA50E23D" modified="2017-01-18" version="1">MTTRDPQQRTVVRGGLVITATDELHADVLIEGERVAALAATGSAAAEAWTADTVIDATGHYVIPGGVDAHTHMELPFGGTAASDTFETGTRAAAWGGTTTIVDFAVQPVGGALREGLDAWHAKAEGNCAIDYAFHTIVSDVNDAVLKEMDALVDSGESTSFKLFMAYPGVFYSDDGRILRAMQRGAANGGLIMMHAENGIAIDVLVEQALAAGHTTPRFHGEVRRELLEAEATHRAIKLAQVAGSPLYVVHVSAASALDELARARDAGLNVFGETCPQYLFLSTDNLAEQGADGFEGAKYVCSTPLRPREHQKALWRGLRTNDLQVVSTDHCPFCYVGQKELGRGDFSKIPNGLPGVENRMDLLHQAVVDGHISRRRWVEIACTTPARMFGLHPRKGTVAPGADADLVVYDPTAVQTVSAATHHMNVDYSAYEGRRLTGRARTVLSRGTVVLDGGRWLGRAGHGTFLRRDTCQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A1</accession>
    <name>A0A1E7N0A1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000100.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3706"/>
    <dbReference type="EnsemblBacteria" id="ARF77981">
        <property type="protein sequence ID" value="ARF77981"/>
        <property type="gene ID" value="B6264_02700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34120">
        <property type="protein sequence ID" value="OEV34120"/>
        <property type="gene ID" value="HS99_0011845"/>
    </dbReference>
    <dbReference type="OMA" id="HWGNARA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="466" mass="49468" checksum="E4CF73741FE3F51E" modified="2017-01-18" version="1">MAVSVGEVVQAFRRDGRIVVVGASLAGLRAAEALRTGGFSGSLTLVGDEPDLPYDRPPLSKQVLLGRARADATTLPQRNSVNAQWRLGTAATGLDLAAKRLRLADGEEIDYDRLLIATGVRARPWFNAAEAALDGVFTVRTSEDAARLERRLSARPSRVLVVGAGFTGSEIASACRERGLEVTVAERGAAPLVGALGGVVGAVAADLQRQHGVDLRTGVMVTALEGDSGGRLERAHLSDGTSLDVEVAVIALGATRNTEWLAGSGLAAGPRGIACDAGCRAFDVQGIVTDDVFVAGDVARSPHPLFGYQFLSLEHWGNAVEQAGVAAHNMINVGPDRRAHLWVPTFWSSQFGVNIKSVGVPNMGDEIVITQGSLAERRFVAVYGFQGRIVAAVTFDQAKWLDFYREQIEVRAPFPPDYATVDRQPGGMRPVPAGFQDPSLPSHGATVTLTGHDPNERRVQFTPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J1</accession>
    <name>A0A1E7N0J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367148.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000614.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1951"/>
    <dbReference type="EnsemblBacteria" id="ARF82785">
        <property type="protein sequence ID" value="ARF82785"/>
        <property type="gene ID" value="B6264_12345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34217">
        <property type="protein sequence ID" value="OEV34217"/>
        <property type="gene ID" value="HS99_0037195"/>
    </dbReference>
    <dbReference type="OMA" id="PHKAIRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15913" checksum="1EC7FBCD497675B2" modified="2017-01-18" version="1">MIDHVLALAATWTAWDGRPFLNADGRTYTPHKAIRRVTDHLLDHWAELEARLAGEPATADHWHASNVTTPADLVPFTVADLDEARSRLTRLGRIWSLRVAALPERQLDDSPGAGWSFRHIVCHVARSGSYYVDSVGPIGQQGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M3</accession>
    <name>A0A1E7N0M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551779.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2269"/>
    <dbReference type="EnsemblBacteria" id="ARF77880">
        <property type="protein sequence ID" value="ARF77880"/>
        <property type="gene ID" value="B6264_02140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34023">
        <property type="protein sequence ID" value="OEV34023"/>
        <property type="gene ID" value="HS99_0011290"/>
    </dbReference>
    <dbReference type="OMA" id="HGYGSHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="28946" checksum="B5E40CA413EA6AB9" modified="2017-01-18" version="1">MTAPQPAVVVLAGGHESDGGRDLVGLVTPSGAPAGRGPVVHAAAAAGRPLAEAVRSALAAGDGPVCVVPMTLGRDPKLVADTARALRWLADDEGRGRLALTAPFGAAEHLIGWLRAAAASAGGGDAVLVTAPAAGPFEDAELFRIARLVRQYGRHRLVEVAFAGGDPGSAEGAERCRLLGADRVTAVPASFGPALPADLRDSDVRDGGPLLRPSAIAGVVAARTAAALHLLGHGEDGILAGLDAEHGHGYAHSHGPGGGHHSDGHGHGHGHKHSHSHSHPHTPAHTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T9</accession>
    <name>A0A1E7N0T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1899"/>
    <dbReference type="EnsemblBacteria" id="OEV34294">
        <property type="protein sequence ID" value="OEV34294"/>
        <property type="gene ID" value="HS99_0036550"/>
    </dbReference>
    <dbReference type="OMA" id="PAPMRPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13198" checksum="13CF10D14A4CC35A" modified="2017-01-18" version="1">MILLRRLLGDVLRRQRQRQGRTLREVSAAARVSLGYLSEVERGQKEASSELLSAICDALDVRMSEVMREVSDELSLAELAAMATLSEGDLLRPVLEPVPLPAPGADRANMSPKAAAMDVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1N1</accession>
    <name>A0A1E7N1N1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5578"/>
    <dbReference type="EnsemblBacteria" id="OEV34575">
        <property type="protein sequence ID" value="OEV34575"/>
        <property type="gene ID" value="HS99_0035250"/>
    </dbReference>
    <dbReference type="OMA" id="EMKRDRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="9209" checksum="618D6D7E178BE638" modified="2017-01-18" version="1">MTRSSFNYSNEDRETKRLRLRADAFQHSAAMERLAEMKRDRPEQYDQMGAVAHLSLGHYEAAKAAAVQLGRNVSAPTDREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1S5</accession>
    <name>A0A1E7N1S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554730.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4266"/>
    <dbReference type="EnsemblBacteria" id="ARF82003">
        <property type="protein sequence ID" value="ARF82003"/>
        <property type="gene ID" value="B6264_26750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34632">
        <property type="protein sequence ID" value="OEV34632"/>
        <property type="gene ID" value="HS99_0009040"/>
    </dbReference>
    <dbReference type="OMA" id="GHWSTHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="55384" checksum="A27DBFC91FA4B374" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y3</accession>
    <name>A0A1E7N1Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intimin/invasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052743428.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4672"/>
    <dbReference type="EnsemblBacteria" id="ARF81942">
        <property type="protein sequence ID" value="ARF81942"/>
        <property type="gene ID" value="B6264_26380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34694">
        <property type="protein sequence ID" value="OEV34694"/>
        <property type="gene ID" value="HS99_0009400"/>
    </dbReference>
    <dbReference type="OMA" id="TVVRAVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003344">
        <property type="entry name" value="Big_1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51127">
        <property type="entry name" value="BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="485" mass="46106" checksum="C112D22E27F07951" modified="2017-01-18" version="1">MAVVVFPLTVPACTTFTVTITGAPAGTASTVITYDGATQTVAVLGGSATVSFTAVGSGTQVVSATYFSGTGGTGTVTGAETGTVTVTPAPAGTISTTLTTPVSGTTTASTIITCGAGLSSINGTLTYTLPGGGTVTATVTNGVVGTTNLGVALTPGQVVTVSFTPAAGTCPACTLAPITVTLPEVSSCSVVIQPLVGPVVVGQPTSVTAVVLCNGVPVSGASVTFTSGTATATATTNALGIAIGSLTFSTAGPATVTATVTATGTACACSGVVSVPITVTVAPQPTCQVLLLPTGPAVVGVPLPVTAVVLCNGVPVSGASVTFTSGTATATATTNALGIAIGSLTFSTAGPATVTATVTATGTACACSGVVSAPITVTVTGTVGSGTTLTAAPACWRVNLPLPLPDVFKATLTATLSPAQAGVTVSFFVANQLVGTAVTDATGTATLQAGLNPLQILAGSYTAHATVGATMLQATNSLTPCLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B4</accession>
    <name>A0A1E7N2B4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388960.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81819">
        <property type="protein sequence ID" value="ARF81819"/>
        <property type="gene ID" value="B6264_25590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34822">
        <property type="protein sequence ID" value="OEV34822"/>
        <property type="gene ID" value="HS99_0010145"/>
    </dbReference>
    <dbReference type="OMA" id="LCGHHDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="11533" checksum="B74871082A3512DE" modified="2017-01-18" version="1">MAIEDTTAVMVGVRLVDEVFAALDAVSAARTPFERGLLGAYRWAVGAQVGAPVTANAAVGAYGPCRAQLLAECQAAQVHIRQGTGPAGETERALGVYMALAWLCGHHDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I7</accession>
    <name>A0A1E7N2I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0034885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000967.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5853"/>
    <dbReference type="EnsemblBacteria" id="ARF77557">
        <property type="protein sequence ID" value="ARF77557"/>
        <property type="gene ID" value="B6264_00215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34904">
        <property type="protein sequence ID" value="OEV34904"/>
        <property type="gene ID" value="HS99_0034885"/>
    </dbReference>
    <dbReference type="OMA" id="KPGWEFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="39205" checksum="3E6754D1E2F1DB12" modified="2017-01-18" version="1">MIVWVNGTFGAGKTSACRELVELLPGSVLFDPELVGFGLRRMLPADRLATVSDFQDLAAWRRLVPETAAALIGEVGGPLVVPMTLLREDYRDEIFGDLAAHGIAVHHFVLDPEETILLDRIARREECPGDPEASERVRTWCFEHLPRYRAARRWLVGDARMLDTSALTPRETAHRIAELVRVGDARCPIVQAPDPTGDTVASAVLFFDEQDRVLLVDPVYKPDWDFPGGVVERGEAPTDAALRETAEELGLRLDPSVLRLLAVDWEPRTGPRRGGLRLMYDGGLLDAAGRQNLLLQQEELRGCRFVTLDEAADLLPPSRYRRLAAALDARRSGELRYLEAGCRVALGLASTADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q5</accession>
    <name>A0A1E7N2Q5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4565"/>
    <dbReference type="EnsemblBacteria" id="ARF78518">
        <property type="protein sequence ID" value="ARF78518"/>
        <property type="gene ID" value="B6264_05970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34979">
        <property type="protein sequence ID" value="OEV34979"/>
        <property type="gene ID" value="HS99_0034790"/>
    </dbReference>
    <dbReference type="OMA" id="TYMWGTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19521" checksum="5E2978B5E4268597" modified="2017-01-18" version="1">MTTKSAASTLANRRTIRHSGRVANRDRNASVPLDAASKAIIEQLQEDGRRPYAAIGKAVGLSEAAVRQRVQKLLDQGVMQIVAVTDPLTVGFTRQAMVGIRVEGDIEPVADALAALDEVDYVVCTAGSFDLLAELVCEDDEHLLELINKRIRALPGVRSTESFVYLKLRKQTYTWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N362</accession>
    <name>A0A1E7N362_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoprenyl transferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554308.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene398"/>
    <dbReference type="EnsemblBacteria" id="ARF82698">
        <property type="protein sequence ID" value="ARF82698"/>
        <property type="gene ID" value="B6264_08230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35126">
        <property type="protein sequence ID" value="OEV35126"/>
        <property type="gene ID" value="HS99_0034140"/>
    </dbReference>
    <dbReference type="OMA" id="TKGQPDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="27393" checksum="0532893814B98E33" modified="2017-01-18" version="1">MYGLYGRRVEVHLARTPHHIGVILDGNRRWAKATGGSTAYGHQRGADKISEFLGWCDETHVKVVTLWMLSTDNLDRPADELVPLLGIIEDAVTGLAAARRWKVNPVGALDLLPQHTADVLKRAAEETAGIDGITVNVAVGYGGRHEIADAVRSLLQEHAGRGTPIEELAEILTVEHISEHLYTANQPDPDLIIRTSGEQRLSGFLLWQSAHSEFYFCEAYWPAFRKVDFLRALRAFEQRHRRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N394</accession>
    <name>A0A1E7N394_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285427.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000209.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4459"/>
    <dbReference type="EnsemblBacteria" id="ARF78441">
        <property type="protein sequence ID" value="ARF78441"/>
        <property type="gene ID" value="B6264_05465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35157">
        <property type="protein sequence ID" value="OEV35157"/>
        <property type="gene ID" value="HS99_0033790"/>
    </dbReference>
    <dbReference type="OMA" id="ATSWIFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31729" checksum="E2D49605D643546A" modified="2017-01-18" version="1">MPLETASETAASETAATAAGKPPAAGTRTEARERAARNRKLTVYAARVGVLVAFLGLWEVGARTEVVDPFNFSQPSRIWDQIWQWVTHGTAQGSLGEQIGYTLYEALSGWVIGVVCGVLLGIALGRIRFLAEVFGPYIKVLNAIPRIVLAPIFLIWFGLGPASKVASAVVLVFFPVFFNAFQGAREVDRNLVANARILGADNRRVTLQVVIPAATTWIFTSLHVSFGFALIGAIVGEYIGATKGLGLLVAAAQGTFNAAGVYAAMTILAVVALVTEGLLTLAEKKLFRWKPADAGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B9</accession>
    <name>A0A1E7N3B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288000.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7684"/>
    <dbReference type="EnsemblBacteria" id="OEV34953">
        <property type="protein sequence ID" value="OEV34953"/>
        <property type="gene ID" value="HS99_0034610"/>
    </dbReference>
    <dbReference type="OMA" id="LYAMEAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="484" mass="53980" checksum="475A766593540668" modified="2017-01-18" version="1">MAEKQPNEKLTTWFARSGWSKGELARQVNRRARQIGAHHVSTDTSRVRRWLDGEQPREPIPKIMSELFSERFGSVVSIEDLGLRAAIPVSTVGGGVDLPWSGPQTVQLISDYSRSDLMLNRRGFLGTSLALTAGAALIEPMQRWLAPGPTGVPTPILTAANGGEAFTGRLSEPELELLEQTTVMFRQWDAQNGGGLRRKAVVGQLHEVTDLLQETYSEDTTKRLFRLTAELAHLAGWMSYDVGMHPSAQKYYVLALHAAKEAGDRPFGALILTDMSRQMIHLNRGEDALELIHLAQYGSRDTATPRQQSLLYAMEARAYATIGEVNRCARAIRLSEDTFTDIRDGDGEPDWLKFFSPAELNAENAHSYRDLAYHSDNAQLYASLSAPVMERAVDLFRQDEDHVRSYAFNLIGMASVHLLQKEAEEAVRYAEQAVDIATKVRSERLNSRVRKTTEAASARFRGVDAVSRLKERVVQDIPEFVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E3</accession>
    <name>A0A1E7N3E3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285487.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000584.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4487"/>
    <dbReference type="EnsemblBacteria" id="ARF82635">
        <property type="protein sequence ID" value="ARF82635"/>
        <property type="gene ID" value="B6264_05325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35192">
        <property type="protein sequence ID" value="OEV35192"/>
        <property type="gene ID" value="HS99_0033930"/>
    </dbReference>
    <dbReference type="OMA" id="FDGPRWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28002" checksum="05D3E854EA770C86" modified="2017-01-18" version="1">MFRRRQKSEDAVEQLADDAISADETADDVEGSAESENVTELDPADKVGLPPAPRPDGPWDHSELETPEEGRVDLGGLLVPGVEGMELRVEVAGDAIVAATLVLGNSAIQLQAFAAPKSEGIWGEVREEIANGITSQGGLVDEEEGPLGWHLRAQVPVQLPDGTQGVQLVRFVGCDGPRWFLRGVISGQAAVQPEMAGVLEQVFRQTVVVRGESPMAPRDPIVLKLPEDAQMVADGGGAAATAGEGEGRYGSLDPFARGPEITEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L0</accession>
    <name>A0A1E7N3L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282752.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5281"/>
    <dbReference type="EnsemblBacteria" id="ARF80696">
        <property type="protein sequence ID" value="ARF80696"/>
        <property type="gene ID" value="B6264_18880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35270">
        <property type="protein sequence ID" value="OEV35270"/>
        <property type="gene ID" value="HS99_0032940"/>
    </dbReference>
    <dbReference type="OMA" id="AGMPEYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7252" checksum="C71B93D92426AFFC" modified="2017-01-18" version="1">MMSKHSQLTALRADADGETLEALVSSSRRLLRFWPQVAAGPEPAAPASVGVRVPSGAQRLVAGMAEYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R5</accession>
    <name>A0A1E7N3R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282819.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5312"/>
    <dbReference type="EnsemblBacteria" id="ARF82923">
        <property type="protein sequence ID" value="ARF82923"/>
        <property type="gene ID" value="B6264_19035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35330">
        <property type="protein sequence ID" value="OEV35330"/>
        <property type="gene ID" value="HS99_0033095"/>
    </dbReference>
    <dbReference type="OMA" id="SGWPAWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20209" checksum="0245C8170CD901CA" modified="2017-01-18" version="1">MEPRPRRRAPERSQAEQDAIFAALVAQFDDPVDLTNPNWPEVENLRAQNELKGGFKDGAGPRAGQGDPDDLSDLAPQPRSRSGRPVLPAAGPGPRDFELAEDTDEGHYVPPEPPPLPPADVTAKFAWLAVLGGPALLLIDAVVWREISGWPAWVGVTAFLGGFVTLVARMKDRDEDEPEDPDHGAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Z2</accession>
    <name>A0A1E7N3Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2417"/>
    <dbReference type="EnsemblBacteria" id="OEV35406">
        <property type="protein sequence ID" value="OEV35406"/>
        <property type="gene ID" value="HS99_0032605"/>
    </dbReference>
    <dbReference type="OMA" id="VGTFFWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198825" evidence="2">
        <location>
            <begin position="30"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="33577" checksum="4CD38141B0C4CEB0" modified="2017-01-18" version="1">MRRTRLISRATAAATTLLLTTGPVPAAGAATPGPANPTAKRLNAYWTPARMAAALPAPAPPTAPTAPTAPTTAAAAPADGPRPGEFIPSSRSFDGIPPVGTFFWTDAGGTGRTCSASVVHSPDHDLVLSAGHCLKGYSGTAPERNLGFVPQYHDGLKPFGIFPVRSNGVYVPQEYYDKGEHAGAAYDFGFAVTEPNQDGERLEDAVGAVRLLTGTGWFHAPVRMIGYPGGAPKPLECLSWTTWWASDDPADPGTFERIACDGFVGGTSGGPMLVPWPGGWAVIGIIGGYHTGGNTPQISYSASFGSATRDLYDAATTGAPPAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N429</accession>
    <name>A0A1E7N429_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553494.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3876"/>
    <dbReference type="EnsemblBacteria" id="OEV35448">
        <property type="protein sequence ID" value="OEV35448"/>
        <property type="gene ID" value="HS99_0032325"/>
    </dbReference>
    <dbReference type="OMA" id="DDNERWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="40450" checksum="C54A7E0577747B6E" modified="2017-01-18" version="1">MIQYLNFLHTTVRFDLADDAAAAFAPIQRFFRHLLADQGAHEPTFRIEVRGYDPSADIAPEVWTLPQSVIRRSNAAEFNFDAHIVDRGGRRLYVNRATLLDAPVDARKDNTFQLRITEASTVQVLDFVRDLVIRHEEDNGTVVLHASGIQRGDEAVIVAGPKGAGKTTTLLSALRRPGWSYFTGDKLFCTLDGGRISVHPWRDYPYVGVGTIRADARLEQLVREQVDPGLDGHEPGHKILMDPDVFESWLGAEFSAEPRRLAAILLPEVRPGEPLAVRHLTDDNERWAHLNKIVDRQVDTTFFTWQSHLVPDYARFYRSLAELRTALDQVAMVRLTGTLDIDPDAVLDPATANSPAPQETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N486</accession>
    <name>A0A1E7N486_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0031840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278169.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5525"/>
    <dbReference type="EnsemblBacteria" id="ARF79383">
        <property type="protein sequence ID" value="ARF79383"/>
        <property type="gene ID" value="B6264_11035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35495">
        <property type="protein sequence ID" value="OEV35495"/>
        <property type="gene ID" value="HS99_0031840"/>
    </dbReference>
    <dbReference type="OMA" id="EWIARAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="32276" checksum="751C35F01078D2B8" modified="2017-01-18" version="1">MDQDLSVITGERRQLINVAYRLLGSLADAEDVVQETYARWYAMPAEQREAVVSPGGWLTTVASRICLNQLGSARARRERYVGEWLPEPLPEHREGPEGAAADPADRITLDESVNMAFLVVLESMTPAERVAFILHDVFQYPFAEVAAVVGRSAAACRQLATSARRRIRAAQAPVPPTGVQAGIVREFKRAWEAKDVRSLMDLLDPEATVIADGGGLVGALLEPLTGSEWIARAYADSARLIAGRTLRECTVSGLPGLVVQQDGVTDTVIAFRIAGERITHIWAVRNPEKLRPWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T5</accession>
    <name>A0A1E7N4T5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0032190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1599"/>
    <dbReference type="EnsemblBacteria" id="OEV35473">
        <property type="protein sequence ID" value="OEV35473"/>
        <property type="gene ID" value="HS99_0032190"/>
    </dbReference>
    <dbReference type="OMA" id="YMKNPRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="56"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="40696" checksum="319B0B999F831E23" modified="2017-01-18" version="1">METNVSVAEHIALAGARLVLPVGVVEGDRLAVEGSRIAAITSGGTEPGDLDLTGYTVVPGFVDLHVHGGGGASYASGIAEEALRAARTHLEHGTTTTIASTVTGEIDEVARQAAVLSELVEDGVLAGIHFEGPFISPGRCGAHRADLLRDPDPALVRKLVDAARGHARMVTLAPELPGGLDSVRMLADLGVIAAVGHTDSDYPTTLEAIDAGATVATHLFNAMPAIAHRAPGPIVALLEDERVTVELINDGVHLHPSVLGLAYGTAGASRVALITDAMGAAGMGDGLYPLGPLQVQVKDGVAMLPDGSSIAGSTLTLDRAFQRSVQVDNLTLNQAAESLSTTPARLLGLADSIGTLEIGKLADLVVVDSGTLDLVAVMRHGRWVLGDEKFAVVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N515</accession>
    <name>A0A1E7N515_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene763"/>
    <dbReference type="EnsemblBacteria" id="OEV35775">
        <property type="protein sequence ID" value="OEV35775"/>
        <property type="gene ID" value="HS99_0007830"/>
    </dbReference>
    <dbReference type="OMA" id="HHERTID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="40854" checksum="2D584477A6D7650D" modified="2017-01-18" version="1">MRVSGVPGGVVHEGSREFLVREGLPTTGAFLDFGALDAGPLRAFPTSGAERLFVLGETDYCTPFAAVGDLVLLDGTTGEVCLGNGGPRRDRLASDLIALAALVREIEAVGEAARRPEALDGRRGPTVVAQVMAGAERRLRQIDPRLFGGDAPPAHWGTALLVRALGWGALPGGPDGPAYEVGPELVAELAALTDEDGGAGLVHRFRPEGLPAALAHEPTRRLLTEVGLPLGGAMFGVCAEPLVTMAEAYPEYFDGEEERPYQRDFLALGDWPTDLTIALDGATGRLELPDWYDDGQPEAYLNRDLSALLYALWTYERLRAEWERWEHGRGRDTWAVFDPQSLLSTVVDRLVEGVDPEAFASPGRSWRLLAEDGHLGGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N551</accession>
    <name>A0A1E7N551_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene722"/>
    <dbReference type="EnsemblBacteria" id="OEV35810">
        <property type="protein sequence ID" value="OEV35810"/>
        <property type="gene ID" value="HS99_0008035"/>
    </dbReference>
    <dbReference type="OMA" id="AERECLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16666" checksum="FF9F0F1D610861A8" modified="2017-01-18" version="1">MSRRPDILGEFTADHKAVTELLDRAETAPAGSAERAELVARLTDLLFTHCAAEEEHLFPAVQHDVPEGGAMVFRSIHDHLAIGQYLSDLQGLDPADPAFDTLLRGLADTLRRHLTGEEKLLFPAARKALPAAARAALGERLRKEREELGDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I7</accession>
    <name>A0A1E7N5I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551048.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene813"/>
    <dbReference type="EnsemblBacteria" id="ARF82956">
        <property type="protein sequence ID" value="ARF82956"/>
        <property type="gene ID" value="B6264_20345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35966">
        <property type="protein sequence ID" value="OEV35966"/>
        <property type="gene ID" value="HS99_0007575"/>
    </dbReference>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="814" mass="87963" checksum="D82EB0B1B0940355" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L9</accession>
    <name>A0A1E7N5L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome accessory factor PafA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286122.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3345"/>
    <dbReference type="EnsemblBacteria" id="ARF82974">
        <property type="protein sequence ID" value="ARF82974"/>
        <property type="gene ID" value="B6264_21050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35991">
        <property type="protein sequence ID" value="OEV35991"/>
        <property type="gene ID" value="HS99_0008270"/>
    </dbReference>
    <dbReference type="OMA" id="YFRGRCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="56321" checksum="F665B18331224AD5" modified="2017-01-18" version="1">MGIETEYGISVPGHPNANAMLTSSQIVNAYAAAMHRARRARWDFEEENPLRDARGFDLAREVADASQLTDEDIGLANVILTNGARFYVDHAHPEYSSPEVTNPRDAVLWDKAGERIMAAAAQRALELPNGQNIHLYKNNTDNKGASYGTHENYLMKRATPFADIVRHLTPFFVSRQVVTGAGRVGIGQDGSAHGFQISQRADYFEVEVGLETTLKRPIINTRDEPHADAEKYRRLHVIIGDANLSEISTYLKLGTTSLVLSMIEDSFIASDLAVDQPVRTLHRVSHDPTLKHLITLRNGRKLTAVQLQLEYFELARKYVEDRFGNDADEQTVDVLTRWEDVLGRLERDPMSLSKQLDWVAKREILEGYRSRDALQWDNPRLHLVDLQYSDVRAEKGLYNRLVARGRFDRLLTEEEVERAVTKPPEDTRAYFRGRCLEQYAEHVAAASWDSVIFDLPGRDSLQRVPTLEPLRGTRNHVKELLDRCRTAEDLLRVLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z7</accession>
    <name>A0A1E7N5Z7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366743.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4976"/>
    <dbReference type="EnsemblBacteria" id="ARF80044">
        <property type="protein sequence ID" value="ARF80044"/>
        <property type="gene ID" value="B6264_14980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36099">
        <property type="protein sequence ID" value="OEV36099"/>
        <property type="gene ID" value="HS99_0031000"/>
    </dbReference>
    <dbReference type="OMA" id="PLDVPWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="21832" checksum="AB3648332931A463" modified="2017-01-18" version="1">MTRDGRSGARPQTGPAAAVHHSLRLAGLAGLALHLTLVLWLVLRPLPVAWVYDANLTPLASLRSSTTWQVVGEFLLLAPLGVLLPLTGGRVRAPWLPSFLRTTGVSALLATGLEFLSSWTPGHVLNVDHILFAVLGVVITHLALVPGLRHLLRTHRPKPRAPRLPVLAGPPTATTVTPTVTVAPVARPRAYAEPAAPTRPLASGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6U3</accession>
    <name>A0A1E7N6U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83128">
        <property type="protein sequence ID" value="ARF83128"/>
        <property type="gene ID" value="B6264_28645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36395">
        <property type="protein sequence ID" value="OEV36395"/>
        <property type="gene ID" value="HS99_0030020"/>
    </dbReference>
    <dbReference type="OMA" id="GHRACML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20871" checksum="016CFE6EC36E486C" modified="2017-01-18" version="1">MPDEVGERPRDGRGYPVPAITPWQDGQPRFALTDHGRSADCALERRCSVCGVFMARGPVWRVVGPAESAAIAEAIAAGRPYRNLAPTMEGPGHRACMLYASMVCPYLARPNARRKVTAGDAEDRLTAAAVRGAARGGTGAVVGFGDYEYAVTDTRVLFRFLDVVEFLPHESADEHLAELRAELARSSARDQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N790</accession>
    <name>A0A1E7N790_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289662.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7880"/>
    <dbReference type="EnsemblBacteria" id="ARF79148">
        <property type="protein sequence ID" value="ARF79148"/>
        <property type="gene ID" value="B6264_09650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36548">
        <property type="protein sequence ID" value="OEV36548"/>
        <property type="gene ID" value="HS99_0028935"/>
    </dbReference>
    <dbReference type="OMA" id="HRHQDGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="37304" checksum="4F0368012BCDA309" modified="2017-01-18" version="1">MPAEPTPALLPQAASWLRRRSWSAADRPVHTLLEAKRRTGRTISVVLPALDEEATVGDIVRTVRRELIERIPLVDELVVVDSGSTDDTAAVAAAAGARVEHRDAILPRLPAVPGKGEVLWRSLLVTHGDIVCFVDADLREFDPAFVTGIIGPLLTDEELQLVKAMYDRPLEVTTIGSATGESAAIVPTGGGRVTELVARPLLNLHWPELAGFVQPLGGEYAARRSLLERLPFPTGYGVELGLLVDALELAGLDALAQVDVGVRHHRHQDGQALGRMAATIYRTALERLDRTHRLKASADLVHPHLTQFTRDPETRSFTAHTHPVTALERPPMHTVPEYAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C1</accession>
    <name>A0A1E7N7C1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289708.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7927"/>
    <dbReference type="EnsemblBacteria" id="ARF79108">
        <property type="protein sequence ID" value="ARF79108"/>
        <property type="gene ID" value="B6264_09425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36590">
        <property type="protein sequence ID" value="OEV36590"/>
        <property type="gene ID" value="HS99_0029160"/>
    </dbReference>
    <dbReference type="OMA" id="PEWVPWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30575" checksum="AF701741A74E1035" modified="2017-01-18" version="1">MRSRTPDRLCAEAVELARQAAEEAVGPEAVGTHLGVQADADRVVTHSFECLDAAYRGWHWAVTVARAPRAKNVTLDEVVLLPGPDAVLAPEWVPWSERLRPGDMGPGDLLPTGADDLRLEPGWTGEDEPAPNSAVALAAEEDVVVTDPHVQPAPARAQINAVAEELGLGRSRVLSRLGLHLAADRWEKSHGPQTPMAQAAPAACGSCGFLIPIGGSLGQAFGVCGNEFGPADGQIVSFAYGCGGHSEAAVIPAPPAPSELILDELVVEPLQLHPDRASGSVEPDAPAEELGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N1</accession>
    <name>A0A1E7N7N1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidored_molyb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2551"/>
    <dbReference type="EnsemblBacteria" id="OEV36712">
        <property type="protein sequence ID" value="OEV36712"/>
        <property type="gene ID" value="HS99_0028080"/>
    </dbReference>
    <dbReference type="OMA" id="FYPLHFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_molyb" evidence="2">
        <location>
            <begin position="295"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="46264" checksum="1AC319DADBF1CE9F" modified="2017-01-18" version="1">MRRIEQTPPPPGPFRPGFWRSPIRGPWLTSVFGLVLLFGIPVLFVTGALSYAAYNPGLGRLNDQTPDKGLLGFYLFDWPTHPYWLYRLTQGVHVTLGVVLVPVVLAKLWSVIPKLFEWPPARSAAHALERLSLLALVGGVVFEFVTGILNTQLYYVFPGSFYTLHFYGAWVFIAAFIVHVCLKLGRMTRALRSRNLLTELRTGLDDTRPELPDPDGLVPTASAAPTMSRRGTLAMVGGGSLLLLAVTAGQSIGGRLRGTALLAPHNREPGSGPNGFQINKTAAAVGINPAHVGPDWRLEVHGLGPMLVFTRTQLLAMPQQAAALPIACVEGWSTPDQHWSGLRLADLAALAGLPDAGSVLVESVQPPGPYSSVVLRGNQIHDPRSLLALRVNGADLSLDHGYPARIIVPANPGVNNTKWVHRLTFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U2</accession>
    <name>A0A1E7N7U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36772">
        <property type="protein sequence ID" value="OEV36772"/>
        <property type="gene ID" value="HS99_0027580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6435" checksum="37D5109E90889913" modified="2017-01-18" version="1">MADLVQQGARVGSPPCEPPGEQMRHQRQRVQDAQRAAAQQRLAAAQSAAARPASEPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V6</accession>
    <name>A0A1E7N7V6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0028510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2463"/>
    <dbReference type="EnsemblBacteria" id="OEV36724">
        <property type="protein sequence ID" value="OEV36724"/>
        <property type="gene ID" value="HS99_0028510"/>
    </dbReference>
    <dbReference type="OMA" id="PVDFQYH"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="14"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV36724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="581" mass="64473" checksum="4CBB9D55108CCB16" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N801</accession>
    <name>A0A1E7N801_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4856"/>
    <dbReference type="EnsemblBacteria" id="ARF82406">
        <property type="protein sequence ID" value="ARF82406"/>
        <property type="gene ID" value="B6264_29185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36811">
        <property type="protein sequence ID" value="OEV36811"/>
        <property type="gene ID" value="HS99_0027825"/>
    </dbReference>
    <dbReference type="OMA" id="HVQRAMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="23795" checksum="59C78384819456AD" modified="2017-01-18" version="1">MTIRVLLADDQALLRGAFRMLIDAEEDMEVVGEAADGREAVELARATKPDIVLMDIRMPGADGLGATAEICADEELSGTRVLILTTFEIDEYVAQALRAGAGGFLGKGADPKELLAAVRTVAAGDALLSPAATRAVIEQFLAQPDPAAVAPSERLSVLTAREREVMSMAATGLTNEEIAERMFVSPFTVRTHVHRAMAKLDARDRAQLVAIAYQSGLVPPGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C2</accession>
    <name>A0A1E7N8C2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6811"/>
    <dbReference type="EnsemblBacteria" id="ARF78606">
        <property type="protein sequence ID" value="ARF78606"/>
        <property type="gene ID" value="B6264_06495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36945">
        <property type="protein sequence ID" value="OEV36945"/>
        <property type="gene ID" value="HS99_0027200"/>
    </dbReference>
    <dbReference type="OMA" id="DRPGRDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="35670" checksum="FFDE7160ED6D3624" modified="2017-01-18" version="1">MKPPTVPTSFPDLRGAATGVGSLPGTDAREAARTATGALEHLPFLPELPARGPGADMIGRSAGLLVELFAQTEPSGWRFTDRPGRDTRRAHSWLGEDLDALEEFTQGHQGALKVQAVGPWTLAANIELKHGEKALADPGACRDIAGSLTEGLRRHLAEVRKRVPGAEVLLQLDEPSLPAVLAGAVKTASGFQRLRAVDRQVAEEVLRELIRGLDAPVVVHSCAPDVPVPLLRRAGVAGISLDFSLLTERQDDDLGEAVEGGTVILAGVVPATDQAVSDPAGSVQGVRTLWRRLGFAPELLGRRVLVTPTCGLAGASPAYARRALSLAARAAQSLVDNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U9</accession>
    <name>A0A1E7N8U9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555719.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6655"/>
    <dbReference type="EnsemblBacteria" id="ARF81606">
        <property type="protein sequence ID" value="ARF81606"/>
        <property type="gene ID" value="B6264_24270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37126">
        <property type="protein sequence ID" value="OEV37126"/>
        <property type="gene ID" value="HS99_0004725"/>
    </dbReference>
    <dbReference type="OMA" id="SWAWTLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="21363" checksum="032C608E12BE93E4" modified="2017-01-18" version="1">MVRAGLNPERLTLAGAELADEAGFGQVSLSALARRFDVKPASLYAHVKNSHELKTRIALFALEELADRVADAVAGRAGRDALTAFANAYRDYARAHPGRYEAARYRLDPQTAAASAGVRHAQMTRAILRGYDLAEPAQTHAVRMLGSVFHGYASLEAAGAFDHTDVAAEQSWAWTLDCLDTALRSRSQPAAPTEDQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X7</accession>
    <name>A0A1E7N8X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0004680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6665"/>
    <dbReference type="EnsemblBacteria" id="OEV37118">
        <property type="protein sequence ID" value="OEV37118"/>
        <property type="gene ID" value="HS99_0004680"/>
    </dbReference>
    <dbReference type="OMA" id="FYAIGVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="622" mass="65043" checksum="C88AAED04FCE23BB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H8</accession>
    <name>A0A1E7N9H8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000117_gene4551"/>
    <dbReference type="EnsemblBacteria" id="OEV37318">
        <property type="protein sequence ID" value="OEV37318"/>
        <property type="gene ID" value="HS99_0005890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198902" description="PG_binding_1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13533" checksum="3A9AB488FA9BA529" modified="2017-01-18" version="1">MQKKWALRAATLTIGATAALGLAVGTANAASTIQWGSTGQPVRCVQQAMNYLDSAGLSVDGQFGQNTYNAVVAYQGSKGIQQDGQVGPQTGGDIKADIYNVYLAAHHSGDYSTQSTMSAWMSNCNSQLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9T4</accession>
    <name>A0A1E7N9T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6215"/>
    <dbReference type="EnsemblBacteria" id="ARF83037">
        <property type="protein sequence ID" value="ARF83037"/>
        <property type="gene ID" value="B6264_24045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37428">
        <property type="protein sequence ID" value="OEV37428"/>
        <property type="gene ID" value="HS99_0004945"/>
    </dbReference>
    <dbReference type="OMA" id="KGGVQMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="28182" checksum="6D8BADA4786499EE" modified="2017-01-18" version="1">MLRGQKALVTGANSGIGRATAIGLGRAGADVVVNYVAGREEAEQVVEEISRFGVRAAAYEADVSQEDQVAAMIARMVQEFGTIDILVANAGLQRDAPFTEMTTAQWQKVLDVNLTGQFLCAREATREFLRRGVVPEVSRAAGKIICMSSVHQLIPWAGHVNYAASKGGVQMMMATLAQELAPHRIRVNAIAPGAIRTPINRDAWDTPDAEKDLLQLIPYGRVGDPEDIAHAVVGLASDLMDYVVGTTLYVDGGMTLFPGFATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA53</accession>
    <name>A0A1E7NA53_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase_S11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0026510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835517.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1129"/>
    <dbReference type="EnsemblBacteria" id="ARF79009">
        <property type="protein sequence ID" value="ARF79009"/>
        <property type="gene ID" value="B6264_08845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37562">
        <property type="protein sequence ID" value="OEV37562"/>
        <property type="gene ID" value="HS99_0026510"/>
    </dbReference>
    <dbReference type="OMA" id="VAAMMSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase_S11" evidence="9">
        <location>
            <begin position="469"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="799" mass="82294" checksum="BD4F2F515DAFDB02" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB4</accession>
    <name>A0A1E7NAB4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">HS99_0025325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290442.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6245"/>
    <dbReference type="EnsemblBacteria" id="ARF79885">
        <property type="protein sequence ID" value="ARF79885"/>
        <property type="gene ID" value="B6264_14110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37629">
        <property type="protein sequence ID" value="OEV37629"/>
        <property type="gene ID" value="HS99_0025325"/>
    </dbReference>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV37629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15195" checksum="59CA5A9AD89009FB" modified="2017-01-18" version="1">MPPKKKKVTGLIKLQINAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQRGMIVPVEITVYEDRSFTFITKTPPAARLILKAAGVDKGSSEPHKTKVAKLTSAQVREIATTKMPDLNANDLDAAEKIIAGTARSMGITVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ1</accession>
    <name>A0A1E7NAJ1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1646"/>
    <dbReference type="EnsemblBacteria" id="OEV37706">
        <property type="protein sequence ID" value="OEV37706"/>
        <property type="gene ID" value="HS99_0025740"/>
    </dbReference>
    <dbReference type="OMA" id="GAHEANI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21300" checksum="E686FC0652816049" modified="2017-01-18" version="1">MARHGPTGGRRAMVAMPAVEQPLGQDGLLQAFLELDTPPGFKAELIEGEIVVTPPPDGPHEGAFSKVAKQFFRNASIELDIAGNKGLVTPGGRFIPDGTVVPEDHFDHLDSWAPAEGVLLVFEITSTSPYKDREPKRKGYAAAGIPCYLLIDRSEGKVTLFSEPQNGDYRALTKTDFGKPIDLPAPFSFTLDTAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN7</accession>
    <name>A0A1E7NAN7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="10" type="ORF">HS99_0024495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290147.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000820.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3445"/>
    <dbReference type="EnsemblBacteria" id="ARF78107">
        <property type="protein sequence ID" value="ARF78107"/>
        <property type="gene ID" value="B6264_03515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37760">
        <property type="protein sequence ID" value="OEV37760"/>
        <property type="gene ID" value="HS99_0024495"/>
    </dbReference>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="484" mass="52634" checksum="584F1D1D30B5A3CC" modified="2017-01-18" version="1">MTAEHSATGPGELDAADYAEFMALAAEEGFDLDGFDGADGAEHVRLPVLAVVGRPNVGKSTLVNRIIGRREAVVEDKPGVTRDRVTYEASWNGRRFKVVDTGGWEIDVLGIDAMVAAQAELGIEQADAVLFVVDATVGATDTDEALIKIIRRAGKPTVLCANKVDGPSTEAEAAYLWSLGLGEPYPVSALHGRGSGDLLDAVMDALPEAPPQTFGDAAPGGPRRIALIGRPNVGKSSLLNKVAGEERVVVNELAGTTRDPVDEMIELGGKTWKFVDTAGIRRRVHLTAGADFYASLRTSAALEKAEVAVVLIDASETLAEQDTRIISMAVEAGRAVVVAYNKWDQLDEERRYYLEREIERDLVQVQWAPRVNVSAKTGRHMEKLVPAIETALEGWETRIPTARLNAFLGELVAAHPHPIRGGKQPRILFGTQAGIRPPRFVLFASGFLEAGYRRFIERRLREEFGFVGTPISISVRVREKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW2</accession>
    <name>A0A1E7NAW2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556743.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6022"/>
    <dbReference type="EnsemblBacteria" id="ARF78026">
        <property type="protein sequence ID" value="ARF78026"/>
        <property type="gene ID" value="B6264_03000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37836">
        <property type="protein sequence ID" value="OEV37836"/>
        <property type="gene ID" value="HS99_0024980"/>
    </dbReference>
    <dbReference type="OMA" id="WESAGEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="411" mass="44583" checksum="177C2D3F4B6053FF" modified="2017-01-18" version="1">MTAQGRPRRLPVTVLGGLATGVRDCAADLARIEVPGLAVLAVRVNSQGRTASWSWRLYERSGPVDGGSVTLPRPCSSHLLPSALLPVLLRAARTGRHRHLLLTLPPGMQADLVALGLLDGRARGQALADDVRIDAVAAAVDLSRIEDDLSGGDRLVDHHLGLGPDDRRTLAETAARHLEAADAVVTASMNDPDPAASARAVALVHHLAPRAAMAHVCHDPLTGALRLPDLSPLVGGNLFDADRVRDRHGPLPIPRQPRRPEFGVRTTHWSSRRPLHAQRLHDALEQICAGVIRGRGHLWLANRPQSIHRWESAGEHLAIETAGTWLPEQDDSAWRSASPQRRTFAALFWDPYYGERRCELTLTGIGLDVPALHRLLDSCLLTDAELALGMHRRQLSDDDPFADALGADPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB09</accession>
    <name>A0A1E7NB09_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="7">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HS99_0025065</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556722.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000684.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6003"/>
    <dbReference type="EnsemblBacteria" id="ARF78012">
        <property type="protein sequence ID" value="ARF78012"/>
        <property type="gene ID" value="B6264_02900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37848">
        <property type="protein sequence ID" value="OEV37848"/>
        <property type="gene ID" value="HS99_0025065"/>
    </dbReference>
    <dbReference type="OMA" id="WTQEMVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV37848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="884" mass="93464" checksum="7F5B812B6548EFBC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB61</accession>
    <name>A0A1E7NB61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278273.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2097"/>
    <dbReference type="EnsemblBacteria" id="ARF79472">
        <property type="protein sequence ID" value="ARF79472"/>
        <property type="gene ID" value="B6264_11585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37921">
        <property type="protein sequence ID" value="OEV37921"/>
        <property type="gene ID" value="HS99_0023915"/>
    </dbReference>
    <dbReference type="OMA" id="FAEPPHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37112" checksum="2C9536F1D360B082" modified="2017-01-18" version="1">MTLSLYLDTERWRTHQRSVLAEFPGLVPVAKGNGYGLGNHRLAEEATLLGTGVLAVGTAYEAADAAEWYGGELLVLTPYRVGEEVLPLPHARVIRTVASVDALRSLHGARVVLECMTTMRRHGVSAADLRTVAAELDGVAFEGLALHLPMDRPDGSSPVEEVVYWVDTAKAAGIPVHTVFVSHLGAAGMDQLSQRYPDTVFRARIGTRLWLGDHGALEVRATVLDVTPVRKGDRYGYRQHPAPADGHILVVAGGTAHGIGLEAPKYVASMGARAKGIARAGLATVNKTKSPFHWAGKQLWFAEPPHMQVSLLFLDGETAPPAIGEELGLQVRHTTTHFDRVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBH5</accession>
    <name>A0A1E7NBH5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551648.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8146"/>
    <dbReference type="EnsemblBacteria" id="ARF79753">
        <property type="protein sequence ID" value="ARF79753"/>
        <property type="gene ID" value="B6264_13320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38037">
        <property type="protein sequence ID" value="OEV38037"/>
        <property type="gene ID" value="HS99_0022785"/>
    </dbReference>
    <dbReference type="OMA" id="TACMRIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29514" checksum="38D175F5AEE4436D" modified="2017-01-18" version="1">MTTAAAPAQPHILLVEDDEVIREATRMALERYGFPVTTAADGLEGLEAFHAVRPDLLLLDVMLPLLDGVGLCRRIREESQLPILMMSARTDPVDVVSGLEAGADDYVVKPFESAVLVARIRTVLRRIRVAPAPAAASPAVLSSPSSSSSPSSSFPPSSASPDSPAAPVAPSPAPSPTHAVRNFDGLQVDTDSMEVRVDGRLVPLTPTELRLLLEFTAAPGIVLERSTLLERVWDYEWGADTRVVDVHVQRLRAKIGSGRIETVRGFGYKLRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM5</accession>
    <name>A0A1E7NBM5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830814.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3007"/>
    <dbReference type="EnsemblBacteria" id="OEV38087">
        <property type="protein sequence ID" value="OEV38087"/>
        <property type="gene ID" value="HS99_0023085"/>
    </dbReference>
    <dbReference type="OMA" id="WFGPHHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="83"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19096" checksum="D3E51B42CF3665F2" modified="2017-01-18" version="1">MSENPGSPPLDFRAGAWLLCAFTLLMVGYFTLPLEWFGDRRPVLSWLVFAGALGGMTWLMVVKIVGVVLGTAKRPVVWLAFLIFLAMTIFSASYYVMGTHRAEFAGLETRLDALYFTVVTMSTVGYGDITPAGQSARLVVVLQIGYNFVFLAAAAGTASQAVRSSIERRVRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS4</accession>
    <name>A0A1E7NBS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033346980.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000388.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5956"/>
    <dbReference type="EnsemblBacteria" id="ARF79687">
        <property type="protein sequence ID" value="ARF79687"/>
        <property type="gene ID" value="B6264_12930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38104">
        <property type="protein sequence ID" value="OEV38104"/>
        <property type="gene ID" value="HS99_0023170"/>
    </dbReference>
    <dbReference type="OMA" id="HMIDVNE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23503" checksum="52E0279E766882A5" modified="2017-01-18" version="1">MSGSHYFSSAPEVASERRPITVSLPDLTLELTTDTGVFSHGRLDPGTRILLEHAPQPRVRGPILDVGCGYGPIALTWATRRKRLPVWAVDVNERALELVRLNAEALRLGNVHAALPDDVPEDLRFATIYSNPPIRIGKAELRRLLTHWLGRLTPDGSAFLVVQKHLGSDSLQKWLNEQGHPTSRVTSVNGFRILEARPRPDAGEGSESGRGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBS8</accession>
    <name>A0A1E7NBS8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0023440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288129.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7130"/>
    <dbReference type="EnsemblBacteria" id="OEV38149">
        <property type="protein sequence ID" value="OEV38149"/>
        <property type="gene ID" value="HS99_0023440"/>
    </dbReference>
    <dbReference type="OMA" id="QQNTGGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="353"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="755" mass="79680" checksum="8722F5E3B95B820C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBZ7</accession>
    <name>A0A1E7NBZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0022765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737821.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8141"/>
    <dbReference type="EnsemblBacteria" id="OEV38178">
        <property type="protein sequence ID" value="OEV38178"/>
        <property type="gene ID" value="HS99_0022765"/>
    </dbReference>
    <dbReference type="OMA" id="PIMNLGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="581" mass="64064" checksum="84182DD60B8A2FE5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB0</accession>
    <name>A0A1E7NCB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366762.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4184"/>
    <dbReference type="EnsemblBacteria" id="ARF80188">
        <property type="protein sequence ID" value="ARF80188"/>
        <property type="gene ID" value="B6264_15845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38294">
        <property type="protein sequence ID" value="OEV38294"/>
        <property type="gene ID" value="HS99_0022425"/>
    </dbReference>
    <dbReference type="OMA" id="GVDAYWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36580" checksum="9D19C5D9E7B3235C" modified="2017-01-18" version="1">MSYRIPTPPPSLEELAKRQQNVVTASQLRARGVPARIITEHCRRGGPWQRLLPRVYLLQSGEPTPEQRMWAALLYAAQNGREEGRREGAVITGAAALALYGFASVPRLPAVTGVDVLVPRQRRLKDAGDVRILRTERELVARSVHGLACAPVARAVADALCEWTADGNAAVPVREVLREAVARPEVRCTVRELATELVESGLTGEPRVRAALDELLAAERDFVLEQVDRLVDEWLLPAPLAAPELRMRGGTYIGIPDLYWPERGVAVEVDSDLRCVSEGEAAWVRGGQHRMEYLGIRVVYVSGARLAAEPEAVGGELREAYRAGGTDVVELLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB8</accession>
    <name>A0A1E7NCB8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290022.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3294"/>
    <dbReference type="EnsemblBacteria" id="ARF82869">
        <property type="protein sequence ID" value="ARF82869"/>
        <property type="gene ID" value="B6264_16445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38339">
        <property type="protein sequence ID" value="OEV38339"/>
        <property type="gene ID" value="HS99_0021835"/>
    </dbReference>
    <dbReference type="OMA" id="EAADNCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="104" mass="10763" checksum="6222DE5FF17E0B9D" modified="2017-01-18" version="1">MTVALRHGLEAVDILRLRRACGAVLQSRNGSTVAFLVPAGTWETWHLPGTSCTAGALVPAATDPRWVIPPSGAGRAARPTDAWVLRSALCEAACTLTAGGLGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ9</accession>
    <name>A0A1E7NCQ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3067"/>
    <dbReference type="EnsemblBacteria" id="ARF82125">
        <property type="protein sequence ID" value="ARF82125"/>
        <property type="gene ID" value="B6264_27515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38479">
        <property type="protein sequence ID" value="OEV38479"/>
        <property type="gene ID" value="HS99_0021530"/>
    </dbReference>
    <dbReference type="OMA" id="WRASHEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22760" checksum="490D1FD831E3C5F4" modified="2017-01-18" version="1">MTEDRGWMHSDDPHVVLTAKGMKAMAHPVRMRLVGLLRKHGPSTATRLAEQLGLNSGATSYHLRQLAAAGFVEEDAERGNARERWWRSAHRMTVWTGEDMADEEPETAVGFLRAVLAGHTLTGQRVLDSFETMPREWRKAVDFSDMLLQITPGEAEQLTAELSAVLRRYRRVGAEGPVPEGSEQVSVVVHVLPDAQGPSAPAEGSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDA5</accession>
    <name>A0A1E7NDA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0020640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552185.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1781"/>
    <dbReference type="EnsemblBacteria" id="OEV38661">
        <property type="protein sequence ID" value="OEV38661"/>
        <property type="gene ID" value="HS99_0020640"/>
    </dbReference>
    <dbReference type="OMA" id="CETMILE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="277"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="38836" checksum="D120B34E8F69CC67" modified="2017-01-18" version="1">MDLSTPPPDLYGRPRTDTLIRRLTAFGDRYSPALGGPLLRRNPRRPLSRPTPPLQLAVAARRQLASEVVELTFADPSGGPLPPWQPGAHLRLALPSGRERHYSLSGDPADRLRYRIAVRRLPGGGGGSAEVHDTLHPGARLTARRPRNGFAFCAEPAVLLLAGGIGITPLLPMAREAQRHGLDWRLVHVGRSADTLPYADELRALDAHRVVPRTDDEHGGVPTGAELLAHAPRGAAVYCCGPAPMLAAVQRALDASPAASLHFERFGAAPITDGEPFAVRIGADGPTLDVPADRSALDVLREARPDLPYSCHQGFCGTCEVRLLAGRPDHRDRRLTPEQRAAGALLPCVSRAAEGETLVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE1</accession>
    <name>A0A1E7NDE1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0020655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282960.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1784"/>
    <dbReference type="EnsemblBacteria" id="ARF77697">
        <property type="protein sequence ID" value="ARF77697"/>
        <property type="gene ID" value="B6264_01070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38664">
        <property type="protein sequence ID" value="OEV38664"/>
        <property type="gene ID" value="HS99_0020655"/>
    </dbReference>
    <dbReference type="OMA" id="SPNNFVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="54063" checksum="A9FC156769C279DC" modified="2017-01-18" version="1">MSKTLTTESGAPVADNQNSASAGEYGPLLLQDQHLLEKLARFNRERIPERVVHARGSGAYGYFEVTDEVSKYTRAAFLSEVGKRTELFLRFSTVAGNLGAGDAVRDPRGFAVKFYTEEGNYDLVGNNTPVFFIKDPIKFPDFIHSQKRDPYTGVQEADNVWDFWAHSPASTHQITWLFGDRGIPASYRHMNGYGSHTYQWVNAEGEAYWVKYHFKTNQGIRSLDGDQAAEVLGADADSHQRDLHQAIERGVFPSWTLYVQLMPVAEAADYRFNPFDLTKVWPHADYPLVKVGRLVLNRNPENVFAEVEQSAFSPNNFVPGIGPSPDKMLQGRLFAYADAQRYRLGVNHTQLPVNAPRATEANNYGRDGHNALNPAGRGKNYEPNSYDGPVQTDGALAAPLKLDGHTGTYTTPAHTKDDDFFQAGELYRLMSEGEKTRLINNIAGSLSQVARDDVVEKNLAHFHAADEEYGARLEAAVARLRAGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDJ0</accession>
    <name>A0A1E7NDJ0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein HS99_0018935</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0018935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286352.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7338"/>
    <dbReference type="EnsemblBacteria" id="ARF81160">
        <property type="protein sequence ID" value="ARF81160"/>
        <property type="gene ID" value="B6264_21665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38751">
        <property type="protein sequence ID" value="OEV38751"/>
        <property type="gene ID" value="HS99_0018935"/>
    </dbReference>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27064" checksum="A16F6351C39E6A1D" modified="2017-01-18" version="1">MSGHSKWATTKHKKAVIDAKRGKLFAKMIKNIEVAARTGGPDPAGNPTLYDAIQKAKKSSVPIDNINRAVKRGGGLEAGGADYQTIMYEGYGPNGVAVLIECLTDNRNRAASDVRVAMTRNGGSMADPGSVSYLFTRKGVVIVPKADGVDEDKLFEIVLDQDPEEINDLGDSFEIVSEASKMVDVRTALVDAGVDYDSAEANFLPSMQVELDVDGARKILKLIDALEDSDDVQNVFANFDIPDEVGAQLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDP0</accession>
    <name>A0A1E7NDP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551467.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene623"/>
    <dbReference type="EnsemblBacteria" id="ARF77631">
        <property type="protein sequence ID" value="ARF77631"/>
        <property type="gene ID" value="B6264_00695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38603">
        <property type="protein sequence ID" value="OEV38603"/>
        <property type="gene ID" value="HS99_0020280"/>
    </dbReference>
    <dbReference type="OMA" id="RYEGVQN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022506">
        <property type="entry name" value="Metallophosphoesterase_PPA1498"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03767">
        <property type="entry name" value="P_acnes_RR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="579" mass="62233" checksum="C4023BDDEC7AC441" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR4</accession>
    <name>A0A1E7NDR4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5134"/>
    <dbReference type="EnsemblBacteria" id="ARF81255">
        <property type="protein sequence ID" value="ARF81255"/>
        <property type="gene ID" value="B6264_22235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38851">
        <property type="protein sequence ID" value="OEV38851"/>
        <property type="gene ID" value="HS99_0019500"/>
    </dbReference>
    <dbReference type="OMA" id="CTNFASE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="420" mass="45855" checksum="55DABA06A4DBA424" modified="2017-01-18" version="1">MNIAALRAARSIDVDAAANSWLALSKQAWQAVNDIHANGVDPLKENWKDRVGEAAGRKLEEHARILEAGADIMRGVVMVLDALSATITRAKLTMNSALDLAKQYGLTVDETTGTVRSASGGADASTDNAVQEINAMLQEALREAAQADKLAAAELRKLAAATCETDPRKALDALQREASQTELAMYTGGIPSGEDPRLVADWWKALTDNQRKQLMLSDPVTLANLPGIPDDVKVGLRGGPNAKYDRVKTVQWALDHWDDTSIDVFGDNCTNFASEALRQGGLRAKGDGLWGWRGDDTWGRSEDAGGDWLSQRVDYSKSWAGAQNMHDFLMRHGSEEVPPDQVKPGDIVYYEEDSDQDDQDKKGAVHHTAVVTAVTPDGDIRYTQHSGGQKNASVGGRIDAFQEQRGHQKLHFVRVNPDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE19</accession>
    <name>A0A1E7NE19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366277.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83174">
        <property type="protein sequence ID" value="ARF83174"/>
        <property type="gene ID" value="B6264_29960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38951">
        <property type="protein sequence ID" value="OEV38951"/>
        <property type="gene ID" value="HS99_0017705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13839" checksum="75AF29E1BB7F62BC" modified="2017-01-18" version="1">MLMVTDLFGMLRRLELTPTATNVLSVMVERQNPGGVVPITQQDIAEELQILPSVVSRGMTLLVERGLVLRKGYRYRLHPAIAGYSSELEMQAAMARAAREGVPPILIPDYQAAPPKAGRSRLRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE61</accession>
    <name>A0A1E7NE61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4353"/>
    <dbReference type="EnsemblBacteria" id="ARF83218">
        <property type="protein sequence ID" value="ARF83218"/>
        <property type="gene ID" value="B6264_30210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38989">
        <property type="protein sequence ID" value="OEV38989"/>
        <property type="gene ID" value="HS99_0017940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="49306" checksum="18D9A9F215AE7F37" modified="2017-01-18" version="1">MIPAVPVVPGQRQALAEVTAVVPTRVAWVPLEHQLVSGAAGRIALDGYSWMQAVHWVHGAGLYVPPPRRPGFCETTVKLAEVLSRLTPCRPSIAYLMRELKCSRRTVQYHRDILQATGLLAWRSVGTRLPLAPGRKRVTCLASEYERLIPVSYDQALGIRTAGEGLERRMTGISEEGRSVIAELGKKAARKLRRPRRTVRHSRARQSVSTPRCTPLEGGTTDCLSSPSVRDSKTTGAARETTSSTRKKRAARQAGQRRRTVLGQVVTAAMMVAGDQLARVAYRRVPWVRQASHDQLRWVLNDLAERGWSQDQVMAWLGEIAAQYGCAGVLWRPERPHSLIAHALRQDVEQERHDQAVAERAAVRVEDTSVAAVQELAGELDFMADLFGAAATTAPVTRQDLQQVAYLPAAALAQMEASGDQAFERFGAGLVARYASLDANPNIQLGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB7</accession>
    <name>A0A1E7NEB7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-2-oxovalerate aldolase</fullName>
            <shortName evidence="9">HOA</shortName>
            <ecNumber evidence="9">4.1.3.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-hydroxy-2-keto-pentanoic acid aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">4-hydroxy-2-oxopentanoate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0018240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:36003"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17153"/>
            <dbReference type="ChEBI" id="CHEBI:73142"/>
            <dbReference type="EC" id="4.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:36004"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22624"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:73143"/>
            <dbReference type="EC" id="4.1.3.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the 4-hydroxy-2-oxovalerate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.39" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557517.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1025"/>
    <dbReference type="EnsemblBacteria" id="ARF83272">
        <property type="protein sequence ID" value="ARF83272"/>
        <property type="gene ID" value="B6264_30510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39040">
        <property type="protein sequence ID" value="OEV39040"/>
        <property type="gene ID" value="HS99_0018240"/>
    </dbReference>
    <dbReference type="OMA" id="CALMVRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008701">
        <property type="term" value="F:4-hydroxy-2-oxovalerate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07943">
        <property type="entry name" value="DRE_TIM_HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01656">
        <property type="entry name" value="HOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017629">
        <property type="entry name" value="4OH_2_O-val_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012425">
        <property type="entry name" value="DmpG_comm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035685">
        <property type="entry name" value="DRE_TIM_HOA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07836">
        <property type="entry name" value="DmpG_comm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03217">
        <property type="entry name" value="4OH_2_O_val_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="44604" checksum="F1DFCF9A7D65302E" modified="2017-01-18" version="1">MSPTAPAVLIHDPTLRDGHHAVRHQLDQGQLRDYAAAADLAGVPVVEVGHGNGLGASSLQIGRAALSDAEMLSTVRDALQRARMAVFMGPGWGTCEDLRGAFRYGAQVFRIAAHCTEADVTERHLGFVAEHGGEGQGVLMMSHMASPAQLAEQCALMVRFGAQAVGIFDSAGHFLPEDVQARIAAISEAVDVPVIFHGHNNLGMAIANSVAAVRTGARIIDACARGFGAGAGNTQLEVLVAVLERLGHPTGIDLNKVLAAADVAERRLMSAPPFIDSVAVMSGRAGVFSGFKTRVLEIAAREGISPGDLFDELGRRQVIAGQEDLIPEAAHRLKEKAVTEHPTTTAGLDPDVEDLLVRELRVKPEALAADATLEEAGLDSLSLVELSVLLSELLGSKVSEDEIHDARTVGGLAVLVENKRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED8</accession>
    <name>A0A1E7NED8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556345.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5136"/>
    <dbReference type="EnsemblBacteria" id="OEV38853">
        <property type="protein sequence ID" value="OEV38853"/>
        <property type="gene ID" value="HS99_0019510"/>
    </dbReference>
    <dbReference type="OMA" id="HRLNDWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14032" checksum="FE6DB8E9B1CF040B" modified="2017-01-18" version="1">MRFSSTPRGARLARRLVCHRLDEWGYGYDSPLNETLTLITAELASNAVRHGRVPGRDFAVRLAEYPDALRIEVSDTRTERMPPAALPRPAADAASGRGLLLVAALADGWGTSPHSAAPGKTVWAECRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEE0</accession>
    <name>A0A1E7NEE0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="14" type="ORF">HS99_0018355</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386175.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000248.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1000"/>
    <dbReference type="EnsemblBacteria" id="ARF83293">
        <property type="protein sequence ID" value="ARF83293"/>
        <property type="gene ID" value="B6264_30640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39060">
        <property type="protein sequence ID" value="OEV39060"/>
        <property type="gene ID" value="HS99_0018355"/>
    </dbReference>
    <dbReference type="OMA" id="GSHATIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV39060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25024" checksum="A532D83A5F47EB7E" modified="2017-01-18" version="1">MADTTTPTPGATTGRPKGVRADADGLTERQRRVIEVIRDSVQRRGYPPSMREIGQAVGLSSTSSVAHQVKALARKGILYQDPQRPRAYRVTADQPQAPTTPAYAPTYDATPVPLVGRIAAGGPILAEQTIEDVFPLPRRLVGEGELFALTVRGDSMIEAAICDGDWVTVRRQPVAENGDIVAAMIDGEATVKRLKREDGRIWLMPHNPAYEPINGDNATILGKVVAVLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEE1</accession>
    <name>A0A1E7NEE1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386822.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4376"/>
    <dbReference type="EnsemblBacteria" id="ARF83238">
        <property type="protein sequence ID" value="ARF83238"/>
        <property type="gene ID" value="B6264_30325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39008">
        <property type="protein sequence ID" value="OEV39008"/>
        <property type="gene ID" value="HS99_0018055"/>
    </dbReference>
    <dbReference type="OMA" id="AGHTFVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13829" checksum="2923498FF842916C" modified="2017-01-18" version="1">MNQPSVQPARTKTSTPATGDYVLYRDIDRYLKGENDHTLICRVLGDWGLYAPGKLKLLVLASGAVIDKAPVLYTRPFDPAEFMHDIDTAPLTALDDGRIMTAAGAWIAAQRTTAVTGTDTPALPGGAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU0</accession>
    <name>A0A1E7NEU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3544"/>
    <dbReference type="EnsemblBacteria" id="OEV39226">
        <property type="protein sequence ID" value="OEV39226"/>
        <property type="gene ID" value="HS99_0000405"/>
    </dbReference>
    <dbReference type="OMA" id="RMTVFNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23660" checksum="595CC022BBFB8769" modified="2017-01-18" version="1">MTDTGTAPNLRELNKRRTREAISHAATRLFIERGFDRTTIAEVAAAAGVAKMTVTNHFPRKEDLFFDLHEEIVDRLPHAVAQRAPGESALAALRRDCLAGLDRRDPRLGFSGPDFARTIAESPGLGARLRELNEQSEAALAEALAEAVHPAPDGPRGVDFESRVAAALLAAVDRAVLSEVFRRTLAGEEQGAIADAVRPSAARAFDRLEGALGSYAVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF43</accession>
    <name>A0A1E7NF43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557165.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4094"/>
    <dbReference type="EnsemblBacteria" id="ARF83332">
        <property type="protein sequence ID" value="ARF83332"/>
        <property type="gene ID" value="B6264_30910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39103">
        <property type="protein sequence ID" value="OEV39103"/>
        <property type="gene ID" value="HS99_0018635"/>
    </dbReference>
    <dbReference type="OMA" id="ICERDAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="31003" checksum="032E438C46528DCE" modified="2017-01-18" version="1">MSSSPSSSVIEARKALANRLVGLRKDAGLTGDELSARCGWHPAKTSRIQSGKSAPSEDDLRAWCTACGADDQIPDLIAAARAVDSMYTEWRRMERTGLRAAQESVAALYRRTGHFRVYASRVMPGMVQTPEYTTAVLRSIQRARVEIDDVADAVEARLERQRMLFSGRHRFGLLIEEWVLRAAVCDPETMAAQLGHLLAVSASPFVSVGVIPTRPDRPHLPVEDFYLFDEAEVAVELTSGYLRITQPREIADYVRTFTDLASMAVHGASARQLITSAIATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD8</accession>
    <name>A0A1E7NFD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288878.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1527"/>
    <dbReference type="EnsemblBacteria" id="OEV39358">
        <property type="protein sequence ID" value="OEV39358"/>
        <property type="gene ID" value="HS99_0001200"/>
    </dbReference>
    <dbReference type="OMA" id="ERFDAKV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="20213" checksum="7760AB06FB28D878" modified="2017-01-18" version="1">MGHGGNVIHELMTDHREVEEMFARIQALPAGDERRREVADDFTIELVRHSVAEEQYLYPAVREHVPGGGDLADKEIADHATVEKLLKEIEGVDCGDARFGVLVDRIISEVSAHIRDEEQNLFPALAEVCSPEQLNELGERVRRAKKLAPTRPHPNAPDNKLLAAGTGLVDRVRDLATGRGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF3</accession>
    <name>A0A1E7NFF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0001485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737759.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000239.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000106_gene5839"/>
    <dbReference type="EnsemblBacteria" id="OEV39402">
        <property type="protein sequence ID" value="OEV39402"/>
        <property type="gene ID" value="HS99_0001485"/>
    </dbReference>
    <dbReference type="OMA" id="VGYLWVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="181"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="48072" checksum="B7D466438BD236F9" modified="2017-01-18" version="1">MKKWIQRARPGGEAVQSLVDALAEVLGRSVVLDDPLVRMICTSRHFGDEDRVRVRTLLQGVADDEPIRYVLSQGVAGWARPGVIPGRDDLGLQPRYCVPIRERGHMLGILMVVAAGEPLTAAEIEAIDVTASAVAAELYEEQLASNVEEEQVRRLVNQLVGTNSAQRCEAHRRLVDDDLLPTGPYVVVTSVAVPGQREASGQVAVALRGALEPFRQTRAARGLLAIEQDRAVLVQVFEREPAEDELDQQCRAVVGSLRTFLGREAATVVGVGGRQTALSRAWTSYDQARVAARAARRLPQLGGIGDWERLGEYAVFLQLPEDVLNDSLVPQPLKRLLKGGGNARLEETLRCFLENAGSVPRTAEILEIHRTSLYYRLRQIQEITGLDLDNGANRLVLHMGLRLWDLLRASRDALPPAVRAASGRPGRGATERGSPVATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG7</accession>
    <name>A0A1E7NFG7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0001755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3126"/>
    <dbReference type="EnsemblBacteria" id="OEV39450">
        <property type="protein sequence ID" value="OEV39450"/>
        <property type="gene ID" value="HS99_0001755"/>
    </dbReference>
    <dbReference type="OMA" id="TDTFAIQ"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="11">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="10">
        <location>
            <begin position="150"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="12">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="467" mass="48496" checksum="F92548B58D3BD00C" modified="2017-01-18" version="1">MSNALITDLYEVTMALSYLREGMTAPATFSLFVRKPPPERGFLVAAGLEPALDHLAGLRVDESDVAAFAEALDRPYADLEPLLGLRFTGELRAVPEGRIVLPGEPLLEVTAPLPEAQFVESYLLNQVCHQSAVASKAARCMLAADGRPVVDFSLRRTHGVPAAAQAARLGALVGFAGTSNVVAAHAYGLRAVGTMAHSYIEAFDDEAAAFRAFARAHPGPVTFLVDTYDTAAGVAVAADVLRESGLHEGCAVRLDSGDLGALAATARRILDGAGLPGVRITASGGLDEYGIDQLVRSGAPIDVFAVGTLVGVSADAPYLDAAYKLVEYDGRPMMKLSTGKVTAPGAKQVHRGPGLTDTIALRDEPAPPGTEPLLRTVVVGGKRTSPPSTLADARAAFEADLAQLPSAARRIRSPQLPSAAVSERLSRLTADVRQRIEDRVAALSRATGGRTESAGPVAGARGGGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM1</accession>
    <name>A0A1E7NFM1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285936.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3128"/>
    <dbReference type="EnsemblBacteria" id="OEV39448">
        <property type="protein sequence ID" value="OEV39448"/>
        <property type="gene ID" value="HS99_0001745"/>
    </dbReference>
    <dbReference type="OMA" id="APTHAFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18979" checksum="91058CA2433744E9" modified="2017-01-18" version="1">MHTVIVYESMYGNTREVAEAIADGVHRADPSGTIDCLALNEAGSDVTRTADLLVVGGPTHMHGMSSGLSRHLAAYTESRKEGHETAAKEARETAESQGLRSWFQDLPRTEPGTYAAAFDTRVDTPRAGGAARGIASRLSRHSYDLVAEPEGFIVEGTDGPLRAGELDRARDWGAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFR2</accession>
    <name>A0A1E7NFR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556221.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000456.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5047"/>
    <dbReference type="EnsemblBacteria" id="OEV39512">
        <property type="protein sequence ID" value="OEV39512"/>
        <property type="gene ID" value="HS99_0002140"/>
    </dbReference>
    <dbReference type="OMA" id="STVWYSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199099" evidence="1">
        <location>
            <begin position="32"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="45831" checksum="26BEFA3CF1D0CE4B" modified="2017-01-18" version="1">MRLRSALPTLTACVLLAATATACGSGGGGTAADSATQELKGQTLTIAAVWSGTEQENFKKVLDAFTAKTGAAVSYTSTGDNLSTVVGSKIEGGDPMDVVMVAQPGVIKQFAGKGWLAPLSSAVTDAAKKDYAGIWSSLGTVNGTQYGLYFKAADKSTVWYSPTAFQNAGVQPPATFDDLLKASRTLSDSGTPAFSVAGQAGWTLTDWFENVYLSQAGPELYDKLTRHEIPWTDPSVLKALTTLGKVFDDKQLVAGGGQGALQTDFPTSVQEVFGAQPKAAMTYEGDFVGGVIASELKKQVGTDAKVFPFPAVDGGKAPVMGAGDAAVVLKGAKHPEAAQKFVEFLSGPEAATVWAKAGGFISPNKAVDPSVYPDDTTRQFAKSVIDAGDAFRFDMSDQAPAAFGGTAGQGEWKDLQDFLADPSDVQGAAARLEADAAKAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFU3</accession>
    <name>A0A1E7NFU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6756"/>
    <dbReference type="EnsemblBacteria" id="OEV39542">
        <property type="protein sequence ID" value="OEV39542"/>
        <property type="gene ID" value="HS99_0002325"/>
    </dbReference>
    <dbReference type="OMA" id="TVRRIWH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="7567" checksum="EB9C48417203AC3E" modified="2017-01-18" version="1">MGAVAAIGERTRVAGLALAGVVVLVAERPEEVRRAWAELPEGAELVILTPDAARAVGRELAEGARPLTVVMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG92</accession>
    <name>A0A1E7NG92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2787"/>
    <dbReference type="EnsemblBacteria" id="OEV39645">
        <property type="protein sequence ID" value="OEV39645"/>
        <property type="gene ID" value="HS99_0002965"/>
    </dbReference>
    <dbReference type="OMA" id="FLHRPCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="36682" checksum="80D6773603B4E6A6" modified="2017-01-18" version="1">MVTLADVARHAGVSSSTVSYALSGKRPISDETRTRIEQAITDLGYHPHAGARALAGKRSHIIALVVPLHPEVHVPTMMEIAIAVTVAAREYGYDVLLLTNDEGPEGVRRVAATGLADGVILMDVRLDDDRIPVLRAQDIPAALIGLPGDPTGLSCVDHDFATAGALCADHLADLGHRDIAFIGYSSRVYRRHAGYAERTLNGFRARAERRELRFLHRPCEGGYESTAGTLARILADRPDTTGFVVQNEAAIGPLLSLLRASGRTVPEDASVIAICPDPMAEQHSPRLTSVTSAKKDLGQVAVEQVMARIAETAAGDRPQERLVLMPPDLVVRESTAPAPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC5</accession>
    <name>A0A1E7NGC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480383.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2880"/>
    <dbReference type="EnsemblBacteria" id="OEV39722">
        <property type="protein sequence ID" value="OEV39722"/>
        <property type="gene ID" value="HS99_0003425"/>
    </dbReference>
    <dbReference type="OMA" id="PFRTLMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="48690" checksum="7ED9086973E017E4" modified="2017-01-18" version="1">MYALRCTSPQGRVGLTSFDQALSHRRCTINTAIRKAARGALPVAVTASVLAAGLTACGTAEQISAGQKVSKAFGRIGDGRSAGFTLSVDATPEQIVAFSKATGDEAADEKSARGLSGLSISVAISADKPLKDVEAFKNAAATDQKNQKDVTLDKSVRVSYRIADKKGTPLLEYRQVDAKGYLQIDLKSVLKLTGQDAAEVDDLAKGLPSDMAPAKSLLSGNWTSIDLQELADAAKKDDGAKGGKPEAVPSVDPQVGQELFNSLKDVFNRTVTFEDKGKKDGTEHIWMSAPARQAVDELYKALKPLSAKFPQQFKKFPTEAPTGVPDRQVGADLYLKDGSLSSATFDLAQLAKKVEPGVNFPVKLTFSQDAPKVEAPSPVPNKMTAEDLMKTFFMVAAGGEGPGLGDGAEPGAVPPFSTDAAPLTDAQVKELTALGMPENQARALNKVGMSFEDIKAMAQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGE6</accession>
    <name>A0A1E7NGE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2935"/>
    <dbReference type="EnsemblBacteria" id="OEV39764">
        <property type="protein sequence ID" value="OEV39764"/>
        <property type="gene ID" value="HS99_0003690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199121" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="11592" checksum="F67644C767161F98" modified="2017-01-18" version="1">MAAASLAGISVVGISGTAHAGTTGSVSISVPGCIGHLNLAPNWAYGHLDSYTTTCWLTVFDRNDQTGKVSSQTISYGPGGSGDTGQFYHDSVVHAVAMAISNGSQSNDTAWYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH1</accession>
    <name>A0A1E7NGH1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367079.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000236.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2946"/>
    <dbReference type="EnsemblBacteria" id="OEV39772">
        <property type="protein sequence ID" value="OEV39772"/>
        <property type="gene ID" value="HS99_0003745"/>
    </dbReference>
    <dbReference type="OMA" id="YLDMEAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199125" evidence="1">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="29684" checksum="DF2DCF25AB0909A3" modified="2017-01-18" version="1">MRLLPLTALLAVPLVLFPAAVPAQASPTASPVPFAALPLDGSTEPPPEYRYTGAGFDACSAPPAEALYIWRTASPYGAVNIYSSGSQRACEQDRLTPEWVATVRAMGWKLVPTHVGLQAPCAKRADKPLRIDPERAEEQGGQEAGEAAAALGELGLGPGSPVYLDMEAYPVGDPVCSRAVVDFTVGWTKALHAAGYRSGFYSSMDSGIADLVAAARAGRAPMPDAVWYARWDGHPSTSGDPGLPDDLWAGHRIHQHRGSADETYGGVTLNVDPDALDGLVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP5</accession>
    <name>A0A1E7NGP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2940"/>
    <dbReference type="EnsemblBacteria" id="OEV39876">
        <property type="protein sequence ID" value="OEV39876"/>
        <property type="gene ID" value="HS99_0003715"/>
    </dbReference>
    <dbReference type="OMA" id="LIFDQYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="21175" checksum="648E359A9260D027" modified="2017-01-18" version="1">MVGSPTFGGDSLPTPPDRIVIDVATVNGSGCPAGSAAVAVSPDNTAFTVTYSSYLAQVGVGSKPTDFRKNCQLDLRVHVPQGFTYAIASADYRGFAHLENGASGVERANYYFQGDSGTTYRSHRFDGPTDDNWQATDSVDVAALVWAPCGEERNFNINTELRVSAGTSDQAHTTSFMTMDSTDGSINTVYHLAWKQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW36</accession>
    <name>A0A1E7MW36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0015350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3133"/>
    <dbReference type="EnsemblBacteria" id="ARF78313">
        <property type="protein sequence ID" value="ARF78313"/>
        <property type="gene ID" value="B6264_04730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32645">
        <property type="protein sequence ID" value="OEV32645"/>
        <property type="gene ID" value="HS99_0015350"/>
    </dbReference>
    <dbReference type="OMA" id="FHFFGHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="56071" checksum="4B2AEEDD77104D0C" modified="2017-01-18" version="1">MSTVPTPTRRRLAGLADRLPERARTHLRQGYWTRLVPLLTLVALATHIPSFARPVWSPDEGFLATQARMLADGGVLYDTVVDRKPPLLPWLYQACFAVFGSASLWPLRTLAVVAHLVTAILLASIARGRWGNRAGAGAGLLYLLVSIGLSPEDTQAATFEVFMLPAMVAAFRYAERRRWLAAGIAVALCSLTKQTGGAVLLPVLWMLLQDARRRGVRWPPALFKIGFGFAVPIALVAVILTKPKGFLFWVVTGSGDYASFGGAWLQMLGRAFGNLGILAAAGLGFLYPVGRRLWFKYRHRPLPVAGEEYGSTTDLWVWLLSSVVAVSVGFHFFGHYYLQLMPPLVLLGTGAVATSAIRWKPVLVYTTVAATAFWTLALAWPGEQMSRNTEVATAVAAQTTPKDTVLVWGMHPELYWLADRKPASRYLTAGFLTNYSGGKDGSPNVGEQFSVNNAWQTFDKELANGLPEVFVDDSGIAPYQPVMVPRIENLLDTHYEMIGVIGDTVVYRLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD0</accession>
    <name>A0A1E7MWD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366535.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000772.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7849"/>
    <dbReference type="EnsemblBacteria" id="OEV32719">
        <property type="protein sequence ID" value="OEV32719"/>
        <property type="gene ID" value="HS99_0015785"/>
    </dbReference>
    <dbReference type="OMA" id="ITWIFAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17545" checksum="6081E25424D8A092" modified="2017-01-18" version="1">MPPDPLSAASSAPLAATPTGGDGGGSTAAPAAVEEVLALRISLGDEVVGEVRTRFRFDVARPYEVLLTFHLGRPDEADWVFSRDLLRDGLQTLSGQGDVKLWPAYCPCHGSTLHLALESPHGSALLEASKPRVRAWLDRTYALVSAEQERDCGPTDAQLAALLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ9</accession>
    <name>A0A1E7MWJ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6100"/>
    <dbReference type="EnsemblBacteria" id="OEV32815">
        <property type="protein sequence ID" value="OEV32815"/>
        <property type="gene ID" value="HS99_0016095"/>
    </dbReference>
    <dbReference type="OMA" id="EAIFPDH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="32782" checksum="C9A64EB33523C6DE" modified="2017-01-18" version="1">MDRVQSASPQHSAGPRGTDRTAGPSGGAAPEAGPGSRRAAAQRQQMRQDLAAAAMELFASQGYEETTVDQIAAAAGVARRTFFRYFRSKEEAIFPDHDDTLVRVADLLASAEPEEHPLDVVCRGIKEVLRMYASTPGVSVARYQLIRQVPALREREIAVVARYERLFTRYLLGRFDTGEPIPSGWQRGGEDDSMLAEVSAAAVVAAHNHVLRRWLRAGGRGDVEAQLEHSFEVIRRTFWAASTPGARRRGPVVAPGASGMPGDGVAESALSASPGGEVLITVARTDAPLDVVVDSIRAALSGTRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWU4</accession>
    <name>A0A1E7MWU4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32916">
        <property type="protein sequence ID" value="OEV32916"/>
        <property type="gene ID" value="HS99_0013610"/>
    </dbReference>
    <dbReference type="OMA" id="HRATIPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="12130" checksum="7DE2C7CCAFE2407D" modified="2017-01-18" version="1">MKLRHAERRDTLPFGIASFRIAGFILWPFGRTTVERRDAGAASCVGNVIWFVFAGWWLALGHLITSIPLFLSIIGIPFGWANLKMIPVSLMPLGREIVSTDQVWGARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV0</accession>
    <name>A0A1E7MWV0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene87"/>
    <dbReference type="EnsemblBacteria" id="OEV32907">
        <property type="protein sequence ID" value="OEV32907"/>
        <property type="gene ID" value="HS99_0039575"/>
    </dbReference>
    <dbReference type="OMA" id="TTRWYHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="21134" checksum="ED3C893C14A192C7" modified="2017-01-18" version="1">MGLSPAVRRTDGRRWADGLSDVSIAGDPLAFPHLARTDLPGHPTTVAGYARLVREIAADRARWEPLVRYDALTRWYARLETGPGYEVWLLSWLPGQSSGFHDHGESSGVMTVVRGELIERSLTHAGEGARTLRPGGQRVFSSGYLHEVVNGALEPAVSIHLYTPGLTAMNQYGAAAVPEQHPEPLPREQAERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX19</accession>
    <name>A0A1E7MX19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279895.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5718"/>
    <dbReference type="EnsemblBacteria" id="ARF81402">
        <property type="protein sequence ID" value="ARF81402"/>
        <property type="gene ID" value="B6264_23040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32986">
        <property type="protein sequence ID" value="OEV32986"/>
        <property type="gene ID" value="HS99_0014010"/>
    </dbReference>
    <dbReference type="OMA" id="HWRIRED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="39955" checksum="6FFD8131489D0CC1" modified="2017-01-18" version="1">MAPRLSVVVPIYNVERYLGECLDSIAAQTFEDFECVMVDDGSTDDGPVVAKAYAARDGRFRLVQQENKGLGAARNTGWRHLTPGTEYLAFVDSDDTLPPHAYQLMISTLDETGSDFAAGNAMRLRTTGLSPSHAHRRPFRETRLRTHVSELPALVTDRTAWNKVYRRSFFDAAGIQYPEGILYEDAPVSVPHHFLAERVDVLAEPIYHWRVREDGALSITQKKTDPRGLIDRVRSMELVREWLLARPEPQFAGYLSAYDRNCLVEEIPMFFWSIPDGDRNYWEVYQRHVSRLLNAIGPERVAELNAQLRLKYRLTLTDAMNRFIAVQRLHRAVRRTRQAAARRAGAIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX35</accession>
    <name>A0A1E7MX35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279865.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5699"/>
    <dbReference type="EnsemblBacteria" id="ARF81420">
        <property type="protein sequence ID" value="ARF81420"/>
        <property type="gene ID" value="B6264_23135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33002">
        <property type="protein sequence ID" value="OEV33002"/>
        <property type="gene ID" value="HS99_0014105"/>
    </dbReference>
    <dbReference type="OMA" id="RAQIVQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25220" checksum="16B6730C943A802A" modified="2017-01-18" version="1">MHTLTTVEFLVRLATGVACGALIGVERQWRARMAGLRTNALVAAGATLFVLYSEAVGDTGSPTRVASYVVSGIGFLGGGVILRDGAGVRGLNTAATLWCSAAVGVLAASGKLDLAVLGTLAVLAVHLVLRPAGRLLDRAPQAGSDPDSTSRATVHLECDRKSETHIRALLLQALAASGLAPTGLRARRTDQGDATSLRATVAINGQVAPALEQVVTRLSLEPGVRDLHWHLDDESDEPGNPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB6</accession>
    <name>A0A1E7MYB6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288777.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000689.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6568"/>
    <dbReference type="EnsemblBacteria" id="ARF80540">
        <property type="protein sequence ID" value="ARF80540"/>
        <property type="gene ID" value="B6264_17935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33435">
        <property type="protein sequence ID" value="OEV33435"/>
        <property type="gene ID" value="HS99_0012710"/>
    </dbReference>
    <dbReference type="OMA" id="PLSYMTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024197">
        <property type="entry name" value="UCP030802"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030802">
        <property type="entry name" value="UCP030802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28864" checksum="4A0B98DBB2BA168D" modified="2017-01-18" version="1">MSGALVASDLDRTLIYSERALALDGPDRAAPRLLCVEVLDGRPLSYLTERAAALLTELGRTAGFVPATTRTVEQYRRVNLPGPQPAYAICANGGQLLVHGEPDPDWRREITARIAAGSAPTEEVVRQLALRADPEWTRKRRVADELFAYLVVERDRLPDGWLAELTGWCAEHGWRVSLQGRKVYAVPQPLCKSAALAEVLHRSGAGTVLAAGDSLLDADLLLAADAAWHPGHGELADCGWTAPGVTALAEVGVAAGEEIVRRFHAAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE2</accession>
    <name>A0A1E7MYE2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0039070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene538"/>
    <dbReference type="EnsemblBacteria" id="OEV33253">
        <property type="protein sequence ID" value="OEV33253"/>
        <property type="gene ID" value="HS99_0039070"/>
    </dbReference>
    <dbReference type="OMA" id="CYLHNAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198548" evidence="3">
        <location>
            <begin position="33"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4968" evidence="5">
        <location>
            <begin position="184"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="293"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="6">
        <location>
            <begin position="755"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="886" mass="96451" checksum="92008AE2F52D29C8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYF0</accession>
    <name>A0A1E7MYF0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0039060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene536"/>
    <dbReference type="EnsemblBacteria" id="OEV33263">
        <property type="protein sequence ID" value="OEV33263"/>
        <property type="gene ID" value="HS99_0039060"/>
    </dbReference>
    <dbReference type="OMA" id="NEQCAPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32850" checksum="89AFC9B28C62DE37" modified="2017-01-18" version="1">MAEGVAGGGAEGVAGDVELTTLLVAAARAIETHRPDALARDHYAEHFVRAAPAATHWPVHPRDVPDGEADPLWGRLGRYFALRTRAFDDQLLRAVQLGARQVVLLGAGLDARAYRLDWPGDCTLYEVDRPEVFAFKERVLDGLEAAATDRPTAHRVAVKTDFRTDWAGALTAAGFHPDHPTAWLAEGLLLHLPGTAERELFAAVDRLSAPSSTLAYEARLGPEAAAVRDHPVHTATRERTGIDLPALLDAEPRPDTPADLTARGWSTTVHTPYEFTRHYGRGPLPEPDDALAANRWVFAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX3</accession>
    <name>A0A1E7MYX3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000507.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000100_gene7490"/>
    <dbReference type="EnsemblBacteria" id="ARF77526">
        <property type="protein sequence ID" value="ARF77526"/>
        <property type="gene ID" value="B6264_00030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33627">
        <property type="protein sequence ID" value="OEV33627"/>
        <property type="gene ID" value="HS99_0038685"/>
    </dbReference>
    <dbReference type="OMA" id="SHNNRIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032109">
        <property type="entry name" value="Big_3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16640">
        <property type="entry name" value="Big_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="622" mass="61251" checksum="731B39EF6ECE0713" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ49</accession>
    <name>A0A1E7MZ49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386555.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000402.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene436"/>
    <dbReference type="EnsemblBacteria" id="OEV33699">
        <property type="protein sequence ID" value="OEV33699"/>
        <property type="gene ID" value="HS99_0038295"/>
    </dbReference>
    <dbReference type="OMA" id="CLPATHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="813" mass="86865" checksum="7622C9411DE29C9E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB7</accession>
    <name>A0A1E7MZB7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroxyacetone kinase subunit DhaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3768"/>
    <dbReference type="EnsemblBacteria" id="ARF78406">
        <property type="protein sequence ID" value="ARF78406"/>
        <property type="gene ID" value="B6264_05255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33778">
        <property type="protein sequence ID" value="OEV33778"/>
        <property type="gene ID" value="HS99_0037860"/>
    </dbReference>
    <dbReference type="OMA" id="MLSAACP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012736">
        <property type="entry name" value="DhaK_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02363">
        <property type="entry name" value="dhaK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="34175" checksum="62E20A9B2BB08B77" modified="2017-01-18" version="1">MKKLINTPESVLEDALAGFAAAHPELTVDIPNRVITRAARPAGPKVALVSGGGSGHEPLHGGFVGPGMLDAACPGEVFTSPVPDQMLAAAKAVENGAGVVFVVKNYTGDVMNFELAAEVAAEEGLEVRTVLVNDDVAVEDSTWTAGRRGTGATVLVEKTAGALAERGAGLDEVAALGERVNAASRSFAVALTAATVPAAGKPGFDLPEDEIEVGVGIHGEPGRRREKLRPARELAAEVVETVLADHHLTAGDEVIALLNGLGATPLLELYVVYGEVAARLAERGITVARSLVGNYVTSLDMAGFSLTLTQADAQLLDLWDAPVDTPALKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH6</accession>
    <name>A0A1E7MZH6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290180.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6311"/>
    <dbReference type="EnsemblBacteria" id="OEV33623">
        <property type="protein sequence ID" value="OEV33623"/>
        <property type="gene ID" value="HS99_0038665"/>
    </dbReference>
    <dbReference type="OMA" id="VQHDIND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198691" description="PG_binding_1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="12603" checksum="A460D29ACE6107E1" modified="2017-01-18" version="1">MLKRNLARLGALAGVAALVTAATLGTASASTSAPSLSLGSSGAGVWCVQHDINDILHLGLSEDGQFGPATQAAVKTFQANWGLQQDGIVGPQTGNYLFYYGDSYYNGTANGYCYSHLPTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ6</accession>
    <name>A0A1E7MZQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1834"/>
    <dbReference type="EnsemblBacteria" id="ARF77744">
        <property type="protein sequence ID" value="ARF77744"/>
        <property type="gene ID" value="B6264_01320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33901">
        <property type="protein sequence ID" value="OEV33901"/>
        <property type="gene ID" value="HS99_0010480"/>
    </dbReference>
    <dbReference type="OMA" id="MGTDNIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="27240" checksum="E1C38FF59E610959" modified="2017-01-18" version="1">MTTALITGATAGIGAAFAGRLARSGYRLVLVARDTERLERASADLHARYGTEVEVLTADLATDEGIATVEARLADAERPVDLLINNAGFGNKGAFGTVPLQDELDMLKVHVEAILRLTTAALPGMRERGRGAIVNVASVAAFLPRGTYGASKAWVVSFTQGVLRDLGGTGVRMMALCPGFTRTEFHQRAGMGTGNIPSWSWLSAERVVNEAMRDLARGRSVSVPGKRYKLAVAVARVLPSGKLGGLSSKAARTYRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR0</accession>
    <name>A0A1E7MZR0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1945"/>
    <dbReference type="EnsemblBacteria" id="ARF79604">
        <property type="protein sequence ID" value="ARF79604"/>
        <property type="gene ID" value="B6264_12375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33703">
        <property type="protein sequence ID" value="OEV33703"/>
        <property type="gene ID" value="HS99_0038120"/>
    </dbReference>
    <dbReference type="OMA" id="HVFGPDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="18494" checksum="F987A5E404D2379D" modified="2017-01-18" version="1">MPDSAPDLDEPIHLAPYDPAWAALGPALADRLADGLWGLGVAAGAEHIGSTSVPGLAAKPVLDVQIGCAPGETDAVVGHVRGLGFEYLGEAGVPGRHYLRRRDDQPANVHVVELGGPLWADNLLFRDHLRAHPEEAARYARAKREAAGATGRLLAYSAHKAAAVAELLARAREARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU8</accession>
    <name>A0A1E7MZU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0010885</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280299.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2182"/>
    <dbReference type="EnsemblBacteria" id="OEV33959">
        <property type="protein sequence ID" value="OEV33959"/>
        <property type="gene ID" value="HS99_0010885"/>
    </dbReference>
    <dbReference type="OMA" id="TAYVLQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="23156" checksum="EFB9988910CB128E" modified="2017-01-18" version="1">MNWLNWLSDFFSDPDHRSGPDSILHRVSEHLTLSGEALLYAALLAVPLGLLIGYTGRGVNVVTALAGAARALPTLGLVTLAVLLAGVGDTAVLFPLVALAAPPLLVAAVEGVRGTDPDVRDAARGIGLTHSQVLLQVCLPSAAPTLLAGFRTATVQVIATATVAAYVGLGGLGRYVIDGLATRQYAVTVGGALLVVLLAVGAQLFFALLARFALPPGVRAQRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N057</accession>
    <name>A0A1E7N057_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4401"/>
    <dbReference type="EnsemblBacteria" id="OEV33853">
        <property type="protein sequence ID" value="OEV33853"/>
        <property type="gene ID" value="HS99_0037520"/>
    </dbReference>
    <dbReference type="OMA" id="ALITWQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="82"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21055" checksum="7133534E0EF58BE5" modified="2017-01-18" version="1">MVLLLVSWQVVVDGPLLGLDRSVRAAVRSSHRDHPSALLDHLGHLLSDLGNGVLAVPVLLAAGGLAARWWRRAGAGRWWLPLPVAALTAALIPLLVVPAKAAFARPGPLGDPLASGQWGWFPSGHTATATFSYGVAALLLARAAGARTARWLTAAAAVSALGVGAGLVWSSFHWLLDVVASWCLAALVLWALDRWLPRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0C3</accession>
    <name>A0A1E7N0C3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3713"/>
    <dbReference type="EnsemblBacteria" id="ARF77987">
        <property type="protein sequence ID" value="ARF77987"/>
        <property type="gene ID" value="B6264_02735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34125">
        <property type="protein sequence ID" value="OEV34125"/>
        <property type="gene ID" value="HS99_0011880"/>
    </dbReference>
    <dbReference type="OMA" id="RHAKITA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="20006" checksum="2FEECDEEC6DD0862" modified="2017-01-18" version="1">MTDRVTLTNVADMTAEQREVYEKFQSNLTRALLLTKGSAGPHLALGGSFTVGLLSLLDREVIVLRVAKLRDSEFERLLHYPLAVKAGLTDTEIEDIEEGRFEEMPPSRAALVRYVDDCILQHKAGHDAFWGLREHYSQNEVAEVTHLAGHSAMTAMFLASLEIPLDQDIASWGRLTEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E7</accession>
    <name>A0A1E7N0E7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-diaminobutyrate 4-aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000822.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1866"/>
    <dbReference type="EnsemblBacteria" id="ARF82550">
        <property type="protein sequence ID" value="ARF82550"/>
        <property type="gene ID" value="B6264_01480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34146">
        <property type="protein sequence ID" value="OEV34146"/>
        <property type="gene ID" value="HS99_0010640"/>
    </dbReference>
    <dbReference type="OMA" id="NLMPGVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004637">
        <property type="entry name" value="Dat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43552">
        <property type="entry name" value="PTHR43552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00709">
        <property type="entry name" value="dat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="472" mass="48443" checksum="1DD1197770FD9D5F" modified="2017-01-18" version="1">MATGATAAAAPPPGDAILRRQCVRESAARTYARSFPIVPVRAHGMTVEGADGRRYLDCLSGAGTLALGHNHPVVLEAIRRTLDSGAPLHLLDLATAEKDDFTSALFENLPAEFAARARVHFCGPAGTDAVEAALKLMQTATGRSGSLAFTGAYHGMTAGALALTGNVAVKEPLPGGGEVVRLPYPYGYRCPFGVGGETGAQLGATYVERLLDDPSGGVVPPAAMILEAVQGEGGVVPAPDGWLREMRRITAERGIPLIVDEVQTGVGRTGAMWAVEHSGIVPDAMVLSKAIGGSLPLAVVVYCEEYDGWRPGAHTGTFRGNTLAMAAGAATLRYVAAHGLAERAAVAGARMAARLRELATELPAIGDVRGRGLMIGVELVDPAAEPDACGARPADPALAVRVREACLARGLIVELGGRHDAVLRLLPPLTITDEQVAAVLERLADAVAAASRPGSASAVAPSASAPAAREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L3</accession>
    <name>A0A1E7N0L3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0036850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366518.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6052"/>
    <dbReference type="EnsemblBacteria" id="ARF78145">
        <property type="protein sequence ID" value="ARF78145"/>
        <property type="gene ID" value="B6264_03750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34229">
        <property type="protein sequence ID" value="OEV34229"/>
        <property type="gene ID" value="HS99_0036850"/>
    </dbReference>
    <dbReference type="OMA" id="HGGFAQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42454" checksum="5961E8A1DD0CDF18" modified="2017-01-18" version="1">MPSTTGDHRTPEGPPTACDPLAGIEAVSQALLAMSRHLEVREVLRRITASARDLLDAEYAALGVPDDHGGFAQFVVDGVTDEQWRAIGPLPRQHGVLAELLHETGPTRLVDVRKAPAFEGWPTAHPEMDAFLGMPVLDTDAAEDEPRVMGVIFLANKRGGGLFTDHDEELLRILAAHAALALSNARLYERSRELTLAGERARIAHDLHDAVSQKLFSLRLTANAAAKLVDRDPARARVELAEVSRLAAEAADELRAVVVELRPAALEEDGLSATLASQVQVLDRAHTADLAFAADGVRALPPAQEAALLRVAQEALHNALRHSGARRVTVTLTGTPARGAVLRVRDDGRGFDPDSVRRAGRHLGLASMRDRAAAVGGTLTLESAPGKGTLVEMEVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M1</accession>
    <name>A0A1E7N0M1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285715.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6049"/>
    <dbReference type="EnsemblBacteria" id="ARF78142">
        <property type="protein sequence ID" value="ARF78142"/>
        <property type="gene ID" value="B6264_03735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34226">
        <property type="protein sequence ID" value="OEV34226"/>
        <property type="gene ID" value="HS99_0036835"/>
    </dbReference>
    <dbReference type="OMA" id="HVLMIRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28588" checksum="B94E80768B53672A" modified="2017-01-18" version="1">MSDVLELVDVSVVREGRALVDQVSWSISEGERWVILGPNGAGKTTLLQIASSYLFPTSGKVSVLGEKLDEIDVFELRSRIGLAGASMFDKLPAEQTVLQTVLTAAYGMTVSWQETYEQSDEGRALALLDRMGMANLTARKFGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVRRLGALAQDEFAPAMAMVTHHVEEIAPGFTHVLMIRQGKVLTAGPIDTELTARNLSKCFGLPLTLERHGDRWSAQGLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R5</accession>
    <name>A0A1E7N0R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550813.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2594"/>
    <dbReference type="EnsemblBacteria" id="OEV34272">
        <property type="protein sequence ID" value="OEV34272"/>
        <property type="gene ID" value="HS99_0036720"/>
    </dbReference>
    <dbReference type="OMA" id="LWAGYGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="31344" checksum="E1B806675CD5B95A" modified="2017-01-18" version="1">MTDTTRPGASERPPVRTASPRRFLMCRPSHFGVSYSINPWMHPEKPVDGERALAQWTRLRDLYRELGHTVEEIDPLPGLPDMVFAANGATVIDGKVLGARFRHAERTAEGPAYLSWFRDQGYSELLWPEHINEGEGDYLLVGRRLLAGTGFRTDPRSHAEAQEFFGVPVTGLTLVNPEFYHLDTALAVLSDDEVMYYPAAFTPGSRAVLRELFPDAILATDEDAAVFGLNALSDGRHVLLPESATHLIGELRRHGFEPIGVDLTELLKAGGSVKCCTLELRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R9</accession>
    <name>A0A1E7N0R9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0036730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2592"/>
    <dbReference type="EnsemblBacteria" id="OEV34274">
        <property type="protein sequence ID" value="OEV34274"/>
        <property type="gene ID" value="HS99_0036730"/>
    </dbReference>
    <dbReference type="OMA" id="CMFHMMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="292"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="10">
        <location>
            <begin position="476"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="598" mass="65028" checksum="5017011D49FAAE5C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V1</accession>
    <name>A0A1E7N0V1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282142.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000332.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6399"/>
    <dbReference type="EnsemblBacteria" id="ARF78732">
        <property type="protein sequence ID" value="ARF78732"/>
        <property type="gene ID" value="B6264_07200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34320">
        <property type="protein sequence ID" value="OEV34320"/>
        <property type="gene ID" value="HS99_0036335"/>
    </dbReference>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="40598" checksum="B01C624A90EEF1BA" modified="2017-01-18" version="1">MSAEPDGVRTGPASQQGMRRANLALVLGVIARGPRSRAEVAAETGLTRAAVSSLAEQLISAGLVVEEGPAAPSGKVGRPGTALGLNPLGPGGLGAEIGVRHLGVCVVDLRGEVRAWRRKESANRGRPPAAVMADLAQLVRSAVAESGLRPAGLTLAVPGLVGGSGVLQRAANLGWQDIPLAAELRPALRLAGDGLAELPVEADNEANLGGLAERWLGGSPEDFLYVSAEAGVGAAVVVGGRLLRGARGYAGELGHVPVHPEGPRCACGAHGCLEQYAGETAVLRAAGLSGLRGDWVTLLAERAGAGDEPARAALAGAGSALGIAAAGAVNLLDPAGVVLGGGYARLAPWLLPAMRRELASRVTVRPWAEDRLTVSRLGRRGPLLGAAVGVVRAIVADPGPLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W8</accession>
    <name>A0A1E7N0W8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551335.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6409"/>
    <dbReference type="EnsemblBacteria" id="ARF78724">
        <property type="protein sequence ID" value="ARF78724"/>
        <property type="gene ID" value="B6264_07150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34329">
        <property type="protein sequence ID" value="OEV34329"/>
        <property type="gene ID" value="HS99_0036385"/>
    </dbReference>
    <dbReference type="OMA" id="FWFNIGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="34127" checksum="2DA8AA35414D06B7" modified="2017-01-18" version="1">MATPQDVLPAPAPSKAPPPAPAPEARIVARRRPGQWIAAAVALLLAAMAVSSVIRNRAFQWGVVADWFTARSVLDGLALTLWLTAATLALGFVLGTVLATMRLSTNPVLRTISWVYIWIFRSTPPLVQLLFFFNIGALYPTLGLGIPFGPEFLTVKTVNLIGPTLTAVIGLTLLETAYAAEVIRGGILSVDRGQLEAAAALGLGRWRVLRRIVVPQAMRAIVPTAGNMLIGALKGTSIVSVLAVSDLLYSVQLVYLQSYQVIPMLMVATLWYLVVTTVLSVGQYYVERHFARGATRDGLPPTPLQRARAALIKVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F4</accession>
    <name>A0A1E7N1F4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557423.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000350.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7079"/>
    <dbReference type="EnsemblBacteria" id="OEV34506">
        <property type="protein sequence ID" value="OEV34506"/>
        <property type="gene ID" value="HS99_0035500"/>
    </dbReference>
    <dbReference type="OMA" id="VATQDRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="25574" checksum="67DCCABA13FC67AC" modified="2017-01-18" version="1">MHSPSPVPPTVVLVHGAFTDASSWAGVVDLLHAAGVAVHAPANPLRGLEHDAACVRSLVRDLDTPVVLVGHGYGGAVITHAAGDADQVVALCYVAAFGLDAGECVLDITNRFAPSPLADATITTAFPSGPDSEVYIRAERFRQVYADDLPPAVEQALSAAQRPIACGALTDRSGSPAWASKPSWYAIATADRMLNPAAQRFMAQRMAATEYVLDASHAVPLSRPDAVVAMIREATRHAMGTFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L4</accession>
    <name>A0A1E7N1L4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558221.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000365.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7496"/>
    <dbReference type="EnsemblBacteria" id="OEV34588">
        <property type="protein sequence ID" value="OEV34588"/>
        <property type="gene ID" value="HS99_0008785"/>
    </dbReference>
    <dbReference type="OMA" id="MGRWHHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="30345" checksum="B113A37213C0B32E" modified="2017-01-18" version="1">MSSFLVIGATGNVGSALIPQLHEQGHHVRALVRSASRAELILAGIDIAIGDLDDAESLTEAASGVDGVFFMQLAPLPAQAENMIKAARTAGVRKIVVLSSIGTVLEPLPVIGARIAARDQVFRDSGLDVTYLRANALMSNSLWWLPTIRDEGRVYDASDPGKTVPVDTFDIARVAAVALTQDGHAGRAYILNGPQALTAREQVEILADVLGRPIEFVPVTPEQFAQHSIEQGIPREMAAAVQNLNELFRAGRAGVISDDITNLTGVAPRTFRQWCEEHAGEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V2</accession>
    <name>A0A1E7N1V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366228.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4250"/>
    <dbReference type="EnsemblBacteria" id="ARF81989">
        <property type="protein sequence ID" value="ARF81989"/>
        <property type="gene ID" value="B6264_26680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34646">
        <property type="protein sequence ID" value="OEV34646"/>
        <property type="gene ID" value="HS99_0009110"/>
    </dbReference>
    <dbReference type="OMA" id="LYWTGHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1477" mass="161152" checksum="460F5BFAF0DCD6E3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N206</accession>
    <name>A0A1E7N206_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tannase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0009460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555947.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N206"/>
    <dbReference type="STRING" id="1894.JOER01000046_gene4656"/>
    <dbReference type="EnsemblBacteria" id="ARF81930">
        <property type="protein sequence ID" value="ARF81930"/>
        <property type="gene ID" value="B6264_26320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34706">
        <property type="protein sequence ID" value="OEV34706"/>
        <property type="gene ID" value="HS99_0009460"/>
    </dbReference>
    <dbReference type="OMA" id="LTPMAKN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="PTHR33938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="542" mass="57283" checksum="CD6D71121AFAB3A9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N207</accession>
    <name>A0A1E7N207_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555902.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4631"/>
    <dbReference type="EnsemblBacteria" id="ARF81910">
        <property type="protein sequence ID" value="ARF81910"/>
        <property type="gene ID" value="B6264_26185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34728">
        <property type="protein sequence ID" value="OEV34728"/>
        <property type="gene ID" value="HS99_0009590"/>
    </dbReference>
    <dbReference type="OMA" id="HGDAWSR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="29933" checksum="63B5029C90D4727D" modified="2017-01-18" version="1">MVSDLPIAIRTDPAHGGRWTSLRAGEREWLWHRRDTARATVRPGDTFIDAGGLEECIPTVRGTPDHGDAWSRPWQRHGDAESLHCPDFVLSRRIDSGPTGLRIGYELRADPGYRFLWAAHALLDVTPEARLAAPDATPTRLFPEAAELLAQPWPDGAHHVTGPWPAPYGLRLDRLGPDDGTAVGAILTDCASVTVTDGPDTLTFSLHADADIPVSTALWRNLRGFPASAPYRSIGVEPMLGSVFDLAEAGPGDAAQVPPSGVLRWHLDITATGTRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N250</accession>
    <name>A0A1E7N250_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555819.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81872">
        <property type="protein sequence ID" value="ARF81872"/>
        <property type="gene ID" value="B6264_25950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34764">
        <property type="protein sequence ID" value="OEV34764"/>
        <property type="gene ID" value="HS99_0009805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="13773" checksum="5EF7AA4B183426D5" modified="2017-01-18" version="1">MIEAVENGALHEIYSDPDGTWHDNAVAGVGGGISAVSVQVKPDSTRVIEAVENGALHEIYSAPDGTWHDNAVPGVGGGISALAVRVKADGSRVIEAVENGALHEIYSAPDGTWYDNAIPGQAGNATALSLDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S8</accession>
    <name>A0A1E7N2S8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290427.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000328.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4557"/>
    <dbReference type="EnsemblBacteria" id="ARF78510">
        <property type="protein sequence ID" value="ARF78510"/>
        <property type="gene ID" value="B6264_05930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34986">
        <property type="protein sequence ID" value="OEV34986"/>
        <property type="gene ID" value="HS99_0034830"/>
    </dbReference>
    <dbReference type="OMA" id="YPIAYGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="34042" checksum="41475AD8B85A8ADA" modified="2017-01-18" version="1">MTTTAPAAPSQAVPLEPAERKPKRKLTPYWLLLPGIVWLVVFFAVPMLYQGSTSLQTGSLEEGFKVTWHFSTYWDAVVEYKWHFVRSFSYAAVATVLCLVIGYPLAYTIAFKANRRWRNVILILVIAPFFTSFLIRTLAWKTILSDGGPVVGALNALHVLDVTNALGLTSGDRVLATPLAVVCGLTYNFLPFMILPLYTSLERIDPRLHEAAGDLYARPFTTFRKVTFPISLPGVVAGTLLTFIPASGDYINAQLLGSPSEQMVGNGIQKQFLNVLDYPTAAALSFVLMALILGMVTVYMRKAGTEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z3</accession>
    <name>A0A1E7N2Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552909.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35054">
        <property type="protein sequence ID" value="OEV35054"/>
        <property type="gene ID" value="HS99_0034545"/>
    </dbReference>
    <dbReference type="OMA" id="EHPFASI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="21749" checksum="C169809E28D0DD6C" modified="2017-01-18" version="1">MSVICPGCAGGEHVLPVPEALGDVVAAAVDPSAVAHLAPPPAPQPGPVRDSAAVAVLVVLAALWLLLGVLSLLRPRPDLDRYGDAYRAGYLLGGLVGPAVLTGAAMVVRMLSRRRARRREEELLWGRQARWQHLVARWRSGWWCRRCQAAFFPVGALHPGAPPSPLLAARHYPAWVLGTPAPATATATGSGSAPSPGPGRQGAGGQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N308</accession>
    <name>A0A1E7N308_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78883">
        <property type="protein sequence ID" value="ARF78883"/>
        <property type="gene ID" value="B6264_08105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35081">
        <property type="protein sequence ID" value="OEV35081"/>
        <property type="gene ID" value="HS99_0034010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15205" checksum="F45B09BE29A86DF3" modified="2017-01-18" version="1">MHPAGGASLRRMTEVRPAVPADAPELVRLRNVMLEEMPSMAALVGPGPWQATAERILRERLAVPSEELTMPSFVVDDPERPGRLAACAVGTLEERLPSPGNPDGLFGFSSVSAPTPTTGCAVTRRPRRSRRPPPGRAAPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J4</accession>
    <name>A0A1E7N3J4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster insertion protein ErpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282750.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5279"/>
    <dbReference type="EnsemblBacteria" id="ARF80694">
        <property type="protein sequence ID" value="ARF80694"/>
        <property type="gene ID" value="B6264_18870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35268">
        <property type="protein sequence ID" value="OEV35268"/>
        <property type="gene ID" value="HS99_0032930"/>
    </dbReference>
    <dbReference type="OMA" id="YQLYFDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12370" checksum="40F94165467DCB35" modified="2017-01-18" version="1">MTVQDETTVESGILLTDAAAAKVKALLEQEGREDLALRVAVQPGGCSGLRYQLFFDERSLDGDVVKDFGGVKVVTDRMSAPYLGGATVDFVDTIEKQGFTIDNPNATGSCACGDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T9</accession>
    <name>A0A1E7N3T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5342"/>
    <dbReference type="EnsemblBacteria" id="OEV35334">
        <property type="protein sequence ID" value="OEV35334"/>
        <property type="gene ID" value="HS99_0033245"/>
    </dbReference>
    <dbReference type="OMA" id="NFEAPQN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="21136" checksum="0AE637D4AE5D44EE" modified="2017-01-18" version="1">MAGEVRAGRGGLPGQGRARITVRPGRRPVRGRTPFAVLVVVLLAAGLLGLLALNTALNEGSFELSRLQKQTTKATDEQQSLQLEIDQSSAPDALAKRAGELGMVPAGGMAFLDVPNGGKVVGTPGPAQDSPPVKKSTVDPWPVKPSPGAQGPAQAQPPAQSSAQPSGSPSPQPSTQQAPAPPTPAASAGDSVIQLNPVSPAPAQHGGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N446</accession>
    <name>A0A1E7N446_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3898"/>
    <dbReference type="EnsemblBacteria" id="OEV35469">
        <property type="protein sequence ID" value="OEV35469"/>
        <property type="gene ID" value="HS99_0032440"/>
    </dbReference>
    <dbReference type="OMA" id="GTYPDWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006633">
        <property type="entry name" value="Carb-bd_sugar_hydrolysis-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00722">
        <property type="entry name" value="CASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASH" evidence="2">
        <location>
            <begin position="91"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="439" mass="48090" checksum="991DC1C826EA5F04" modified="2017-01-18" version="1">MVGDLAAKTRNSPPHTTFWLRPGTHTLDADRYAQVVPKEGDSYLGAPGAVLDGRRTNEYAFSGAATDVSVRYLTVQGFVAPQNEGVVNHDSADGWVIEHTTIQGNSGAGLMAGAHQRVRANCLRGNGQYGINAYKSGAPVSDLLVEGNEITGNDTDQWERRQPGCGCTGGVKFWAVNGADVRGNWVHDNRGPGLWADTNNNDFRIEDNVLEANDGAALIYETSYNAVVRGNTIRRNDWVEGRNAADRGDNFPYATVYLSESGGEPRIPARTDRIEVSRNVLEDNWSGITLWENADRFCNSPANTSSGDCTLLVKRTDSCSQPTIATPPLYGDCRWKTQRVDIHDNRFELDPSVVGCTVKCGRMAVLANYGTYPDWSPYKGEPVAEAITGGQQNRWHDNTYLGPWSFVAHDPSRTLDFGQWQGRPYQQDAGSTLRPRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F4</accession>
    <name>A0A1E7N4F4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="8" type="ORF">HS99_0006465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282894.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5351"/>
    <dbReference type="EnsemblBacteria" id="ARF80756">
        <property type="protein sequence ID" value="ARF80756"/>
        <property type="gene ID" value="B6264_19230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35565">
        <property type="protein sequence ID" value="OEV35565"/>
        <property type="gene ID" value="HS99_0006465"/>
    </dbReference>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="411" mass="42086" checksum="7A6E19A60D60BE98" modified="2017-01-18" version="1">MAAPQNYLAVIKVVGIGGGGVNAINRMIEVGLKGVEFIAINTDAQALLMSDADVKLDVGRELTRGLGAGANPEVGRKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVANIARSLGALTIGVVTRPFTFEGRRRANQAEDGIAALREEVDTLIVIPNDRLLSISDRQVSVLDAFRSADQVLLSGVQGITDLITTPGLINLDFADVKSVMSDAGSALMGIGSARGEDRAKAAAVMAISSPLLEASIDGARGVLLSISGGSDLGLFEINESAQLVSEAAHPEANIIFGAVIDDALGDEVRVTVIAAGFDGGQPPAIVRDPVVKSTTPAAPATPPAAPERPAGRPSYGSIGSVTSRSEGEAQAAPTRSAETQAATTTAASVPPQVQQSTRQPFVESPAEELDVPDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V7</accession>
    <name>A0A1E7N4V7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0031825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5528"/>
    <dbReference type="EnsemblBacteria" id="OEV35493">
        <property type="protein sequence ID" value="OEV35493"/>
        <property type="gene ID" value="HS99_0031825"/>
    </dbReference>
    <dbReference type="OMA" id="NSSIVWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198772" description="Histidine kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="277"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="499" mass="52643" checksum="E49D37BF2DC98A5E" modified="2017-01-18" version="1">MFNRFTSRLSLRARLLVLALALVTTGLAVSDTFVLGTVRAQLVEQLDEQLQRYGQPLSRKAPVQVAAPGAAKPVVSGRRISLPSQYLVQWLSSDGKVQAVLRQPVSDTDPAPQLAGLDPTQTAPDTPFDLPDQRGHHSWRVLVLPLQAPRTPAPGAGAYVSPASSPTYVMVAVSREDIDATTGRLSTSFLAIGGGVLLLITALGFFAVRAGLRPLRRIEAGAERIAAGELSHRMPELSPGTEVGRLSVALNGMLTQIEAAFAARAESEARMRRFVADASHELRTPLAGIRGFAELYRMGALPTETDVTRTMSRIESEAVRMGALVEDLLVLARLDEERPLDLAPMDLRTLAADALHDLTALDPSRPVALTGPAGTGAPGAAPVLGDEARLRQVVTNLVGNAVKHTPPGTPVRIGVGGGADGVCLLEVADSGPGLTEEQAQRVFDRFYRVDASRSRDNGGGGGLGLAIATALTRAHGGTLTLDTAPGAGATFRVELPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N522</accession>
    <name>A0A1E7N522_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828796.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene731"/>
    <dbReference type="EnsemblBacteria" id="ARF81011">
        <property type="protein sequence ID" value="ARF81011"/>
        <property type="gene ID" value="B6264_20765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35801">
        <property type="protein sequence ID" value="OEV35801"/>
        <property type="gene ID" value="HS99_0007990"/>
    </dbReference>
    <dbReference type="OMA" id="LTVPHFH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025450">
        <property type="entry name" value="YndJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14158">
        <property type="entry name" value="YndJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="29330" checksum="223020ACB634F989" modified="2017-01-18" version="1">MGKGTTELVDLLVLLGMGAVLPLGLALIDEPGLARVRRLWPLAAVPGALSLWLPRGGLATGCALLYALGTLLVALHAPLRLARTRSLAAAEVAVLTALTAPSVAGVALVAERSGYPLFGFEPHILALTVPHFHYAGFTAALIAGLVCRADHGSRPARCAALSVPAGTLLVLAGYFLGDWWQFAGAVVLSAGMWLVGLISWRELRPRTADRATARLLAASSAVLALTMLLALWWALGRAAGLPHPTLTWMAATHGLGNALGFALCAVLAWRRITTTVETHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B5</accession>
    <name>A0A1E7N5B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281815.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene936"/>
    <dbReference type="EnsemblBacteria" id="ARF80837">
        <property type="protein sequence ID" value="ARF80837"/>
        <property type="gene ID" value="B6264_19720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35643">
        <property type="protein sequence ID" value="OEV35643"/>
        <property type="gene ID" value="HS99_0006950"/>
    </dbReference>
    <dbReference type="OMA" id="AQILHWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="26856" checksum="2FD2653D34E0F5B4" modified="2017-01-18" version="1">MRSSTRLVTATAAALLCVGALSACGPDNSGQDGGKTAAPAPTGTTATGTTAPSAGSTGSTSKPDGKGIPAKAWMDTKNIPMDETYHYAPLAANAKPVTGAVGFKGMELCHSPLPKGEEYLFTEGTAKAKASVGFGGDRWTAQQTLFFWGDPTHSSGNGQSVGVIKDRLATAVKDCAKTAPGATVKVNSADDAPYFAATLTVPQADGSTATLHEYVVNAGGTVSELSVWATTKGGAQPKDAWKAPDDKYVGTGMTSALCEALPGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F1</accession>
    <name>A0A1E7N5F1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0008720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7312"/>
    <dbReference type="EnsemblBacteria" id="OEV35926">
        <property type="protein sequence ID" value="OEV35926"/>
        <property type="gene ID" value="HS99_0008720"/>
    </dbReference>
    <dbReference type="OMA" id="MNTDGIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198777" description="Histidine kinase" evidence="4">
        <location>
            <begin position="24"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="205"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="5">
        <location>
            <begin position="318"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="520"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="867" mass="92197" checksum="7550D60CA2687EE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5H1</accession>
    <name>A0A1E7N5H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene905"/>
    <dbReference type="EnsemblBacteria" id="OEV35946">
        <property type="protein sequence ID" value="OEV35946"/>
        <property type="gene ID" value="HS99_0007105"/>
    </dbReference>
    <dbReference type="OMA" id="HWPCFEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045697">
        <property type="entry name" value="DUF5919"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041334">
        <property type="entry name" value="HEPN_SAV2148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19319">
        <property type="entry name" value="DUF5919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18725">
        <property type="entry name" value="HEPN_SAV2148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV2148" evidence="1">
        <location>
            <begin position="13"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5919" evidence="2">
        <location>
            <begin position="225"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="43514" checksum="11A9D5BDF230C052" modified="2017-01-18" version="1">MTGRALVPAQGGPVEVPALAWSAGEWEDAYQRVRLSGRAYVWLNLVEQRLRSLVDEVLHPIYAPAHGEDWVTAAAGPAGEEWAHRAGAVREVSRRKGYLLDPADDDPLVFLTLPQLRELMVQHWPCFEPYLADRREIELALDELEVARHVVSRNRVLTQTVLAQTERAAARLLAVLDGGAGGVPADVVESLVAGRYADVVAVHADRVRLQRDLPVEDLLDGARRLDALGIGLGMLCQNYTGKRLVRLAGEGCRVRLLFLNPASSAVRRRERELGLSRGELSRSIEMNIMHVRRVRARLRDQGGFEIRVFDETPRFTAYLVEGPRPTGPVAGRRQSRDLGVIQPYLRRSRGMESPALILRGGAGQQPGGTEPGLLEVYREEFEGIWADSRNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M8</accession>
    <name>A0A1E7N5M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387846.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene487"/>
    <dbReference type="EnsemblBacteria" id="ARF78831">
        <property type="protein sequence ID" value="ARF78831"/>
        <property type="gene ID" value="B6264_07790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36007">
        <property type="protein sequence ID" value="OEV36007"/>
        <property type="gene ID" value="HS99_0031345"/>
    </dbReference>
    <dbReference type="OMA" id="GHTSFNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="31910" checksum="92D4DD4D1C8309C1" modified="2017-01-18" version="1">MPAARPATAPAPATAADPRPTQPLPTLDLLLLAVSIGGISFSGPLISATAAPALAIAFWRNVMSVGALGPYALLRHRAELRGIGRRALLLAVAAGALLAVHFALWMPSLRMTSVASATALVTTTPLWTILLMRLFGVRAPRMVWLGTVVAFAGVLVLTGVDLSMSPRALLGDALALAAGLAAAGYMLLGAEVRRAVSTTAYTLVCYATTAVGLLAICLVTGTRLSGWSAGAWWQIVLLMVTAQLLGHSLSNRVVRNLGPSITSTAILLETPGAALIAALWLGQWPPAAAYPAVVLILLGLVLVARGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N1</accession>
    <name>A0A1E7N5N1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name evidence="2" type="ORF">HS99_0008655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386506.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000381.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7299"/>
    <dbReference type="EnsemblBacteria" id="ARF82982">
        <property type="protein sequence ID" value="ARF82982"/>
        <property type="gene ID" value="B6264_21430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36000">
        <property type="protein sequence ID" value="OEV36000"/>
        <property type="gene ID" value="HS99_0008655"/>
    </dbReference>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30685" checksum="5E133DBBAA8767DF" modified="2017-01-18" version="1">MTLIEALPWLERFHGKTIVIKFGGNAMVDESLKAAFAQDVVFLRYAGLHPVVVHGGGPQISAQLDRLGLESNFTNGLRVTTPETMDVVRMVLAGQVQRELVGLLNEHGPFAVGMTGEDAHTMTAVKRYAVVDGEQVDIGLVGDIVNIEAGAVKALIADGRIPVISSIARGADGHVYNINADTAAAALAVALGAEMLVVLTDVEGLYKDWPNSDDVISQLNATELETLLPGLASGMLPKMEGCLRAVRSGVGTARVLDGRVQHSLLLEIFTDEGIGTMVVPDDEPTVTGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5T2</accession>
    <name>A0A1E7N5T2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histidinol-phosphate phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.15</ecNumber>
            <ecNumber evidence="7">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0031590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="6"/>
    <dbReference type="EC" id="3.1.3.25" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282273.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000436.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6332"/>
    <dbReference type="EnsemblBacteria" id="ARF78789">
        <property type="protein sequence ID" value="ARF78789"/>
        <property type="gene ID" value="B6264_07535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36045">
        <property type="protein sequence ID" value="OEV36045"/>
        <property type="gene ID" value="HS99_0031590"/>
    </dbReference>
    <dbReference type="OMA" id="WRTRAYG"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV36045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28828" checksum="6857C11200D4C08C" modified="2017-01-18" version="1">MADYHDDLRLAHVLADSADSVTLERFRALDLKIETKPDLTPVSDADKAAEELVRSVLQRARPRDAVLGEEFGLQGSGPRRWVIDPIDGTKNYIRGVPVWATLIALLEDGPDGVERPVVGIVSAPALQRRWWAAEGLGAYAGRSLAKASRIHVSGVSRIEDASFSYSSLTGWEDRGRLDPFLDLTRACWRTRAYGDFWSYMMVAEGAVDIAAEPELSLWDMAAPCIVVEEAGGRFTGLDGIPGPGGADAVASNGLLHEETLRRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L5</accession>
    <name>A0A1E7N6L5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280453.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7159"/>
    <dbReference type="EnsemblBacteria" id="OEV36347">
        <property type="protein sequence ID" value="OEV36347"/>
        <property type="gene ID" value="HS99_0029735"/>
    </dbReference>
    <dbReference type="OMA" id="RIFLIAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="468" mass="51870" checksum="31B3313727E0EBBB" modified="2017-01-18" version="1">MPVDTSPETQQDRQQSLATAAARNLATTTKSAPQMQEITSRWLLKVLPWVEAHGGAYRVNRRLTYTVGNGVVEFIKTGSQVRVIPAELGELALLRGYEDDEVLTALADRCQQRDFGPGEVLTTQGEAADRIFLIAHGKINKFGTGKYGDETVVGVAGDGDRFGDDSLLNPDAVWEYTAKTATAGVALTLSRDDFARIRDNAPSLQEHLASFLALPLQAQNERGEAEIAMSAGHHGEYELPGAFVDYELKPREYELSVAQTILKVHTRVADLYNEPMNQIEHQLRLTIEALRERQEHEMINNPEFGLLNNADFDQRIQTQSGPPTPDDLDELLNRRRDPDYLLAHPRTIAAIGREFNARGIYPHHVDLGGQQVPAWRGVPILPCSKIPITKENTSSILVIRTGEDNQGVIGLHQTGLPDEYQPSLSVRFMGIDEKAIISYLVSAYYSCAILVPDAVGVLENVEIAHRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L9</accession>
    <name>A0A1E7N6L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553075.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000604.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4881"/>
    <dbReference type="EnsemblBacteria" id="ARF82385">
        <property type="protein sequence ID" value="ARF82385"/>
        <property type="gene ID" value="B6264_29060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36325">
        <property type="protein sequence ID" value="OEV36325"/>
        <property type="gene ID" value="HS99_0029600"/>
    </dbReference>
    <dbReference type="OMA" id="KFGHEEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7444" checksum="246F10E55D0FC890" modified="2017-01-18" version="1">MFESLKNLADKATDLAREHGDVLGQGLEKVGDVIDDHTDGKYSGQIDTGVEKAKDFLRNLDGDRKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W1</accession>
    <name>A0A1E7N6W1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0029250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene238"/>
    <dbReference type="EnsemblBacteria" id="OEV36430">
        <property type="protein sequence ID" value="OEV36430"/>
        <property type="gene ID" value="HS99_0029250"/>
    </dbReference>
    <dbReference type="OMA" id="FNMQNME"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="956"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1995"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3046"/>
            <end position="3121"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4118"/>
            <end position="4194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1976"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3026"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4097"/>
            <end position="4119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1980"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2030"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3081"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="4153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="4476" mass="480052" checksum="7D5C505B4590875B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W8</accession>
    <name>A0A1E7N6W8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284285.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8073"/>
    <dbReference type="EnsemblBacteria" id="ARF79816">
        <property type="protein sequence ID" value="ARF79816"/>
        <property type="gene ID" value="B6264_13690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36203">
        <property type="protein sequence ID" value="OEV36203"/>
        <property type="gene ID" value="HS99_0030635"/>
    </dbReference>
    <dbReference type="OMA" id="CANVEMH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="8531" checksum="C96EB3B6121E8D8A" modified="2017-01-18" version="1">MQNVKKVAVLSAAAAGLVLGAAGSAAASAGAEGVAAGSPGVVSGNQLQVPVHVPINLCGNSINVIGVLNPAFGNTCANVEMHPKPADDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X9</accession>
    <name>A0A1E7N6X9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome C biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8060"/>
    <dbReference type="EnsemblBacteria" id="OEV36213">
        <property type="protein sequence ID" value="OEV36213"/>
        <property type="gene ID" value="HS99_0030700"/>
    </dbReference>
    <dbReference type="OMA" id="RWFWRQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="8">
        <location>
            <begin position="52"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="588" mass="62882" checksum="ABFDE2361C45A1F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N707</accession>
    <name>A0A1E7N707_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">HS99_0029455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289749.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene194"/>
    <dbReference type="EnsemblBacteria" id="OEV36486">
        <property type="protein sequence ID" value="OEV36486"/>
        <property type="gene ID" value="HS99_0029455"/>
    </dbReference>
    <dbReference type="OMA" id="RNKYVMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="17848" checksum="8227962F2F22E109" modified="2017-01-18" version="1">MIEIPQGSRNKYVMDFDAGRIRLDRTLFTATRYPADYGYVEGTLGGDGEPLDALVLGGEPAVPGCVLTCRAVGMWVMRDERGPDQKILCVPAHDPRYAALRDIGDLREYDLLEITHFFQVYKDLERGKSVEGSHWAGREAAGTEIAESRARATGTRFARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N709</accession>
    <name>A0A1E7N709_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TerD-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554207.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene197"/>
    <dbReference type="EnsemblBacteria" id="OEV36459">
        <property type="protein sequence ID" value="OEV36459"/>
        <property type="gene ID" value="HS99_0029440"/>
    </dbReference>
    <dbReference type="OMA" id="PQWGVPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="351" mass="36555" checksum="87D510D211F2CBDE" modified="2017-01-18" version="1">MSVALTKGGNVSLNRQAPGVRSVRVCLGWTAGPGYDLDASALLCGASGKVLTDQHFVFFNNLQSPDGAVRHLGADGGGGEGEDRERIEVRLADVSADVQKVVFAVAIYDAAQRRQAFGQVRGAYVRLTDADGGAEVARYDVIPETGSETAMVFGELYRNGADWKFRAVGQGYASGLAGIATDFGVDVLQPAPAAPSAPASAPAPAPLPPMPAAAPAAVVPAVPKTQPATGSSPVTCFFDPTHGVGSAVVLWQPQWGVPRQVETCAACAQRVQTTVPPFYTPQQAGYPQQQVQPHVPAQQQDQGGRRFGTGAMLGAGAAGLVGGMLLNEALSDDEPQVVVNNYYEDDDDSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F3</accession>
    <name>A0A1E7N7F3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0028055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280630.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000739.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7787"/>
    <dbReference type="EnsemblBacteria" id="ARF82281">
        <property type="protein sequence ID" value="ARF82281"/>
        <property type="gene ID" value="B6264_28455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36632">
        <property type="protein sequence ID" value="OEV36632"/>
        <property type="gene ID" value="HS99_0028055"/>
    </dbReference>
    <dbReference type="OMA" id="EWMKGNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="5">
        <location>
            <begin position="81"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="32990" checksum="7C8F700519BEBCAF" modified="2017-01-18" version="1">MTSSFRRPRTALPAVALLAAALAVGCGHGTSGGTGAAAAAVPTTATTSAGQSSAGPTDGAFKDLEQHFGARLGVYAVDTGSGREVAYRSDERFAFASTIKSLLAGALLRTASDQELDKVVTYRQDEVLTWAPITSRHVDTGMKVRDLAAAALEYSDNTAANLLMTELGGPENLQRTLRELGDPTTNVNRNEPTLNEATPGDPRDTSTPRAFAADLRRYVLGDVLTEDRRRMLTDWMVGNTTGAPFIRAGVPAHWKIGDKTGNGGYGTRNDVAVAWPSGGRSPVVLVVMSDRGKADATSDDALIAEATKAVVTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G5</accession>
    <name>A0A1E7N7G5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280612.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000524.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7778"/>
    <dbReference type="EnsemblBacteria" id="ARF82290">
        <property type="protein sequence ID" value="ARF82290"/>
        <property type="gene ID" value="B6264_28500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36625">
        <property type="protein sequence ID" value="OEV36625"/>
        <property type="gene ID" value="HS99_0028010"/>
    </dbReference>
    <dbReference type="OMA" id="IVQTGMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="34654" checksum="74FA1B8ACDE64EAD" modified="2017-01-18" version="1">MATTSDELLHRVTAPAPDEAPTVDAPGADRAAAPGLPGPRGFSGPSGHPDLPELADIEDPRQVAPADARELTRVLLARLSMLEEGTAEYSYVRATLIELNLSLVRYAIRRVGNRQEPEEDLIQVGSLGLIKAIDRFDPGHGAEFVTFALPTILGEIRRHFRDATWAVHVPRRLQELRITLAKARDVLFQRLGRSPTAAELADHLDLPEEEVIEGLAAANGHTAGSLDASGTEGEEDLGPLAQRLGEEDRRFDTIENLIVLKPLVAALPERDRQILSMRFGEELTQSQIGARLGLSQMHVSRLLNRTLTRLRADLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L2</accession>
    <name>A0A1E7N7L2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="6" type="ORF">HS99_0028445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366974.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2476"/>
    <dbReference type="EnsemblBacteria" id="OEV36692">
        <property type="protein sequence ID" value="OEV36692"/>
        <property type="gene ID" value="HS99_0028445"/>
    </dbReference>
    <dbReference type="OMA" id="RSDGFFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="14359" checksum="73A9F08601C66C0A" modified="2017-01-18" version="1">MGALRDEHHNGWLMPSGNYPAAVYDDEWVDQETVPAVPAPAKIVSLRPTGFEAARTVGEHIRASTPVVMDLTEMDEAEAKRMVDFASGLIFGTRGGIERIARRVFLLTPADVEVMVIDRPLDETGFYNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L8</accession>
    <name>A0A1E7N7L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ToxA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550707.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2493"/>
    <dbReference type="EnsemblBacteria" id="ARF81508">
        <property type="protein sequence ID" value="ARF81508"/>
        <property type="gene ID" value="B6264_23650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36681">
        <property type="protein sequence ID" value="OEV36681"/>
        <property type="gene ID" value="HS99_0028365"/>
    </dbReference>
    <dbReference type="OMA" id="YGFRCEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="27505" checksum="753275E685E09382" modified="2017-01-18" version="1">MSVHQYDRIGEAFEGFKALPLVRYGEVPSVLALVGDVRGKTVLDLACGTGFYSRELRRRGAAEVLGIDISTEMIAAARALEERDPLGIRYEVGDVAELRPLELQFDSALAVQCLNYAEDVAALERMCRNVHRSLVPGGDFFVFAQNPDYRFDCASLEQYGFRCEPTGEEAGAGPRVRVTALLDPQPISIVATCPRREVYEQSLRAAGFHDLEWVPLRISEEGLREFGEDFWADALAHPPLELLRCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N859</accession>
    <name>A0A1E7N859_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386746.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4791"/>
    <dbReference type="EnsemblBacteria" id="OEV36834">
        <property type="protein sequence ID" value="OEV36834"/>
        <property type="gene ID" value="HS99_0027505"/>
    </dbReference>
    <dbReference type="OMA" id="AVHCLYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045382">
        <property type="entry name" value="DUF6529"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20139">
        <property type="entry name" value="DUF6529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20739" checksum="22A5A425EFC231BC" modified="2017-01-18" version="1">MTGLAHPAEHRRLYDVLWLLLPVAVVVGLFWFGRAHTPNYETSLFGNRGSDAQLLKAQMGSALMGLALIQLFLALWIYGRLPALRAAPHRVHTTHRLIGLTAFLLSLPIARHCITAYGVQFTPTRVALHSLTGCFLYGAFVAKVIVVRHRRWPGWALPLAGGTLVTAIALIWYAAPLWYLNGLQAPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N876</accession>
    <name>A0A1E7N876_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonylcarbamoyl-AMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282075.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6434"/>
    <dbReference type="EnsemblBacteria" id="ARF78700">
        <property type="protein sequence ID" value="ARF78700"/>
        <property type="gene ID" value="B6264_07020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36854">
        <property type="protein sequence ID" value="OEV36854"/>
        <property type="gene ID" value="HS99_0026665"/>
    </dbReference>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22347" checksum="53D64E7F684530AF" modified="2017-01-18" version="1">MSRRYDCADAGDRATGLREAASAIRRGELVVLPTDTLYGVGADAFSPEAVGELLAAKGRGRNMPSPVLVGSPTTLHGLVTDFSEQAWELVDAFWPGGLTLVARHQPSLRWDLGETRGTVAVRMPLHPVAIELLNTTGPLAVSSANKTGGPSPATCDEAQAQLGDAVSVYLDGGKADHATASSIVDVTGKVPVLLRAGAISIEQLREVVPDLEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N897</accession>
    <name>A0A1E7N897_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830396.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6844"/>
    <dbReference type="EnsemblBacteria" id="ARF78637">
        <property type="protein sequence ID" value="ARF78637"/>
        <property type="gene ID" value="B6264_06660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36917">
        <property type="protein sequence ID" value="OEV36917"/>
        <property type="gene ID" value="HS99_0027030"/>
    </dbReference>
    <dbReference type="OMA" id="HEFPFLF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16433" checksum="23EDF330023DF793" modified="2017-01-18" version="1">MSESATPGPLELLARYRRAMLDLDADALAELYAEDGVHEFPFLFPGMPERYRGREEVRAGYRAAWGASEARPREIRQVAVHPGADPEVLTVEQLVVGTVASTGKEFALPGLLVMRARGGQLVHVRDYMDGLGVARAMGRLSAVAARLEAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K2</accession>
    <name>A0A1E7N8K2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene147"/>
    <dbReference type="EnsemblBacteria" id="OEV36984">
        <property type="protein sequence ID" value="OEV36984"/>
        <property type="gene ID" value="HS99_0003880"/>
    </dbReference>
    <dbReference type="OMA" id="WAEGGMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198871" description="Beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="42525" checksum="79DB912DBF44CC55" modified="2017-01-18" version="1">MPVAALACALLTAVALGTAVPAVAAPATRAAVSVEHTRDQLPDLNPKALQQALSSAPDRVTGVLARVSGPDGHWTGTYGTADVTTGAPVPVDGRFRLGSVTKTFIATVVLQLAAEDRVDLDQPVQRYLPNVLPDSYPPIPVRTLLNFTSSLPELTADDLPTTPDGIVEHRFDDHPLAELVAKAVRHERPFSDPGRMQVYGATGYYVAAMLVENLTGHPYQQEITTRIVQPLHLRDTTAPETGTTIPGPHSHGYIAVPQPAGGTQLVDITEQNPGAGGMVSTTADLDRFLTALFRGRLLPPTEQAELFEVPDVPYLGGTDHDPGHGRAYYSAGLLRATLPNGVTVWGKTGSTFGYTDGMFTTRDLRRRLTYSFNPTTGGGNDLALVNRILSATFTDPTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K6</accession>
    <name>A0A1E7N8K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389300.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81704">
        <property type="protein sequence ID" value="ARF81704"/>
        <property type="gene ID" value="B6264_24895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37021">
        <property type="protein sequence ID" value="OEV37021"/>
        <property type="gene ID" value="HS99_0004105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25702" checksum="1CFBF1D7E98655EC" modified="2017-01-18" version="1">MAARRHTVPGHLVGAGRVTLSRTGGGAGPDWGAYAVLYTTRPVDGGSEAVIGYCMPDDPLLDPAWGLHRQQPYGPAGTARHPLGDYAAASDPARGRSESPASYGQRMALFLLRIATATRLVHSPRITDLPWADWTLATEQHVHLAPDPDHPGRGGPATTRFALAGSSPSGPSSPEPVGGPGWGRRPRRVPEGSSTAMTTATARPRGDPGRCPGRRLPTAISPLVLPGTPRRRFQGHPGRVARDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M9</accession>
    <name>A0A1E7N8M9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000139_gene2709"/>
    <dbReference type="EnsemblBacteria" id="ARF81707">
        <property type="protein sequence ID" value="ARF81707"/>
        <property type="gene ID" value="B6264_24910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37018">
        <property type="protein sequence ID" value="OEV37018"/>
        <property type="gene ID" value="HS99_0004090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="502" mass="55860" checksum="DA7AA7DF6EA3B47B" modified="2017-01-18" version="1">MAHALLQNLWFHHTDNVDLNTITIHHQHVTIHAATTGDRAACPSCGTSSARVHSRYRRRLAHTAAGQRRVVIELQVRRFRCRELSCPRATFVEQAAGLTFRHGRRTQGLHAALQRLALMLAGRAGSRLADTLAVPVSRSTLLRLIRALPERAAATPRVLGIDEFALRKGHNYGTILIDIETRKPVDLLPDRTTSTVARWLAEHPGVEVICRDRSPAFAEAGRLGAPEAVHVADRWHIWSNLAEAVEKTVVQHRALLREPSDNTTATAAAVMENLDLEAASPMEPRTTGRLSDRVREQHAAVHALLDQGIALRVIARQLRLARNTVRRYAHAACADELLVGRWTGRASILDPYKPYLHQRWAEGCTVAHRLFEEVRERGYPGGENVVKVYVAKLRESLPHVPPRKAPSVRDVTTWLTRRPDRLTEGQAQQLKAILARCPALDRTAHHVRAFAELMNNREGRQLDKWIVAVQADDLPALHTFVTGLGQDLDAVTAGLGSVRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N924</accession>
    <name>A0A1E7N924_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37191">
        <property type="protein sequence ID" value="OEV37191"/>
        <property type="gene ID" value="HS99_0005110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10902" checksum="F6DC13818A8ACCAF" modified="2017-01-18" version="1">MVRVARVAHWGRGVGNVLPVDRALSLPAGRHSTGLQRLAVTEAVRGSFDQAHDAVERRCGNVRGKRRLEGLVVAAAVDVDDFCRTRIPFVRGRQVRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N953</accession>
    <name>A0A1E7N953_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555259.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1348"/>
    <dbReference type="EnsemblBacteria" id="OEV37226">
        <property type="protein sequence ID" value="OEV37226"/>
        <property type="gene ID" value="HS99_0005335"/>
    </dbReference>
    <dbReference type="OMA" id="VGNNWDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198892" evidence="1">
        <location>
            <begin position="35"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="45100" checksum="91F06F19D36E9AAC" modified="2017-01-18" version="1">MSRTGPRRRLGVRSLCTLAVALGLLAPAAATSSAAPGATPALREVMFVGNNWDGTADVIESSGALSKVGRIDVIPDKDQRLAEIYLNPVKLGYFLGIRLGPGEGHDQFVDDMYSTPDGTAVVVSRPSFADVVSLDLATGRVNWRFPVAGYRADHMALSPDGTRVAVSASTANTVHVLDVRTGAELGSFHTGDKPHENIFTDGGRQLWNMSIGNVETALDAPWLDWTKGDRHITVVDAATLTPIREIDMRKRLDDAGLGGLSNAVRPAVFSPDGTRLYFQVSFFNGFLEYDVAADRITRVKTLPVDPAASTDRTTWPNDSRHHGLSMSPSGDRICVAGTVDDYATVVDRATLQEGPLVPASKPYWATVSGDGKSCLISESGADQVTAIDFATGRKTASVAVGRHPQRVRLGHVPTGWTGPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9I2</accession>
    <name>A0A1E7N9I2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556452.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5438"/>
    <dbReference type="EnsemblBacteria" id="OEV37355">
        <property type="protein sequence ID" value="OEV37355"/>
        <property type="gene ID" value="HS99_0006100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="17825" checksum="87B167622166F683" modified="2017-01-18" version="1">MRHPRALIAGGAALLLGAGLLGWHVYLDQTSYRPPAVTLSHGECRGLLDDPGVAEVLGGAPRVSVRTDYRTADETNPASVRCSVNGEDGRLLTAEAAFGAVLPGGNSAGAIGFACTLDGKPTGYRAVVTLTGKDGKVLADGPGRARMNELARGFAERAAGKQLGCAGGAESVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9J1</accession>
    <name>A0A1E7N9J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0006070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556461.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5444"/>
    <dbReference type="EnsemblBacteria" id="OEV37349">
        <property type="protein sequence ID" value="OEV37349"/>
        <property type="gene ID" value="HS99_0006070"/>
    </dbReference>
    <dbReference type="OMA" id="FAMDFAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="22100" checksum="2F6249ED011F0E5E" modified="2017-01-18" version="1">MPKQVDHQERRETIARALWRVVEQRGATHLTLRDVAQEAGISLGQLQHYFGSRAELLAFAMDLAGEQSSLRVGRALAGLGERPHPRAVLRAMLVELLPLHADARATSRMSAAYVLEALHDEGVHARARGSLLHGRAAVEQVVRQAIADGMIAADRDPVVETDLLLALTGFTTLLELNVVEPAAVLAAVDQYLDRLFAAGAGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9T6</accession>
    <name>A0A1E7N9T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000672.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1327"/>
    <dbReference type="EnsemblBacteria" id="OEV37243">
        <property type="protein sequence ID" value="OEV37243"/>
        <property type="gene ID" value="HS99_0005430"/>
    </dbReference>
    <dbReference type="OMA" id="GIRSEWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9902" checksum="EA0A7CAB189DDDBC" modified="2017-01-18" version="1">MTIVRRIHEAGITSEHAYAAAFGSIGLSLLSWIASMKAEQAGVERADRWGIFVGEWAPTFFGLGLALAGYEREAPAAKGSRSAWLDHPGGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Z4</accession>
    <name>A0A1E7N9Z4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366630.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79085">
        <property type="protein sequence ID" value="ARF79085"/>
        <property type="gene ID" value="B6264_09280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37488">
        <property type="protein sequence ID" value="OEV37488"/>
        <property type="gene ID" value="HS99_0026075"/>
    </dbReference>
    <dbReference type="OMA" id="VMEGIFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="14244" checksum="D2C332A8626C9C99" modified="2017-01-18" version="1">MEGSYKLLRQTSRWARFARVTVSGETSAEPAVQVGADVFGWRVRSYGPTVGAVQVGDEQFRAEALDGVRYALARLPEESRGLSVSVVEIVTSPVDTSPGDVKFAAAHAVWAMVGRQPGRQPWIDADGVPVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA31</accession>
    <name>A0A1E7NA31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556478.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5450"/>
    <dbReference type="EnsemblBacteria" id="OEV37343">
        <property type="protein sequence ID" value="OEV37343"/>
        <property type="gene ID" value="HS99_0006040"/>
    </dbReference>
    <dbReference type="OMA" id="KSPMGDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11711" checksum="11069EC926B6FCE0" modified="2017-01-18" version="1">MPTHIQGVWDLTIVTPIGRVRPVVELGLQDGKLVGTARGAGENLPLRDIVLDGDRLTWKQSVTRPVRLDLTFTVTVEGDTLTGTSKAGRLPASKVTGRRRRSDEAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA69</accession>
    <name>A0A1E7NA69_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0026570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286461.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1117"/>
    <dbReference type="EnsemblBacteria" id="ARF78998">
        <property type="protein sequence ID" value="ARF78998"/>
        <property type="gene ID" value="B6264_08785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37572">
        <property type="protein sequence ID" value="OEV37572"/>
        <property type="gene ID" value="HS99_0026570"/>
    </dbReference>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="33648" checksum="B2EE5F2CE18390D7" modified="2017-01-18" version="1">MTTTTSRIPVTKAVVPAAGLGTRFLPATKATPKEMLPVVDKPAIQYVVEEASAAGLSDILMVTGRNKRALEDHFDRAYELEELLVRKGDEDRLRRVRESVELANMHYVRQGDPKGLGHAVSVAEQHVAGQPFAVLLGDDLIDPRDPLLARMIEVQQELGGSVVALMEVDPSQIHLYGCAAVKANGFGEDVFQVTDLVEKPEPGEAPSNYAVIGRYVLDPLVFDVLRETPPGRGGEIQLTDALRELTTRDPEAGGQVHGVLFKGRRYDTGDRADYLRAIVRLAAEREDLGPEFRSWLREFVGSELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB9</accession>
    <name>A0A1E7NAB9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280704.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1711"/>
    <dbReference type="EnsemblBacteria" id="ARF79902">
        <property type="protein sequence ID" value="ARF79902"/>
        <property type="gene ID" value="B6264_14200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37645">
        <property type="protein sequence ID" value="OEV37645"/>
        <property type="gene ID" value="HS99_0025415"/>
    </dbReference>
    <dbReference type="OMA" id="YVYEALY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="24485" checksum="34C2ED061FFB612D" modified="2017-01-18" version="1">MTPIRVVVADDQELVRAGFGMILDAQPDIEVVAEACDGAEAVEAVRAHNPDVLLLDVRMPVMDGLEAARRVCAEFPATKVIMLTTFDIDDYVFDALYAGASGFLLKDVRRDDLAHGVRMVASGEALLAPSVTRRLIGEFAARRPGSHERAVRPPSKLLEQLTLREHETLRLIARGLSNAEIAAELVVSEHTVKTHVSNVLSKLGLRDRVHAVVFAYEAGAVVAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAH4</accession>
    <name>A0A1E7NAH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553947.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1652"/>
    <dbReference type="EnsemblBacteria" id="ARF79957">
        <property type="protein sequence ID" value="ARF79957"/>
        <property type="gene ID" value="B6264_14500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37700">
        <property type="protein sequence ID" value="OEV37700"/>
        <property type="gene ID" value="HS99_0025710"/>
    </dbReference>
    <dbReference type="OMA" id="GQQARFQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="552" mass="60756" checksum="1DDF746AD4EE4D59" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM9</accession>
    <name>A0A1E7NAM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1643"/>
    <dbReference type="EnsemblBacteria" id="OEV37746">
        <property type="protein sequence ID" value="OEV37746"/>
        <property type="gene ID" value="HS99_0025755"/>
    </dbReference>
    <dbReference type="OMA" id="FSHGYCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="42889" checksum="79E3992A608534D4" modified="2017-01-18" version="1">MAKAAGAATTGVSRAGLIGISVGVLAAGAAAGVAVERLTVGRAMRRRARAELEASAPYGSLRGRPLTVVAPDGTELYVELDGTGWDEPDSAPGTPEPLTVVFSHGYCLNQDSWHFQRAALREGLRLVFWDQRSHGRSERSRSFLAGEPAGIDQLGGDLKAVIDAVAPTGPLVLVGHSMGGMTVMALADQHPELFRERVAGVALAGTLAGNWNEVSLGLPTVGAKLFKRVAPGVVKLLGRQVELVEASRRIGSDFAAVFYRRFSFGGRDVDPGVVSFAEQLLDATPIDVVAEFFPVFGAHEKYEALAALRGLPALVLAGTKDLLTPSAHSEAMAERLPGAELVLVEGAGHLVLLERPELVDRELALLLRRAADFAGAAPLPPSVLALALAEEPRADGSGDTAAQDPAVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAW0</accession>
    <name>A0A1E7NAW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0024910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289158.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000244.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6036"/>
    <dbReference type="EnsemblBacteria" id="ARF78038">
        <property type="protein sequence ID" value="ARF78038"/>
        <property type="gene ID" value="B6264_03075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37827">
        <property type="protein sequence ID" value="OEV37827"/>
        <property type="gene ID" value="HS99_0024910"/>
    </dbReference>
    <dbReference type="OMA" id="EHRQREM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="380"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="610" mass="68214" checksum="6B6FAEEFE7E9AF7F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB14</accession>
    <name>A0A1E7NB14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000254.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5998"/>
    <dbReference type="EnsemblBacteria" id="ARF82582">
        <property type="protein sequence ID" value="ARF82582"/>
        <property type="gene ID" value="B6264_02880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37877">
        <property type="protein sequence ID" value="OEV37877"/>
        <property type="gene ID" value="HS99_0025085"/>
    </dbReference>
    <dbReference type="OMA" id="LTIRINW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15615" checksum="1703433BC5C1CC8D" modified="2017-01-18" version="1">MPNSFPTPSSSRPWPVPGTPLLPRLELEPTMSRDGIFDGAWWPRSNHVLAELPDLITALGAHFGRIVRVGLDTTAWDGVPRSLAANGLTIRINWFAGSDATISVTRGFQDHFLLLVVPPGTNPATAASAMAGASATGNHTPAAELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB34</accession>
    <name>A0A1E7NB34_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="6" type="ORF">HS99_0023795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030059672.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000941.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2120"/>
    <dbReference type="EnsemblBacteria" id="ARF79451">
        <property type="protein sequence ID" value="ARF79451"/>
        <property type="gene ID" value="B6264_11465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37901">
        <property type="protein sequence ID" value="OEV37901"/>
        <property type="gene ID" value="HS99_0023795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="45" mass="5167" checksum="690F9E3417629CEF" modified="2017-01-18" version="1">MSKRTFQPNNRRRAKTHGFRLRMRTRAGRAILAARRGKGRASLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA1</accession>
    <name>A0A1E7NBA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386764.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000491.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7089"/>
    <dbReference type="EnsemblBacteria" id="OEV37753">
        <property type="protein sequence ID" value="OEV37753"/>
        <property type="gene ID" value="HS99_0024450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30960" checksum="BB48CD339197E50C" modified="2017-01-18" version="1">MSGGNDGGRPVRRPLGLPGRPRAEEWLEPAFALLPEPAAVPEPVAGPAVVPQQVEGEPGVVRQKSAPSTSDAPEEPVGAAGKPLGPGLRAELEAVLMVVDEPVGEERLAGVLERPRAEVAQALRELAAEYAAQGRGFDLRLVAGGWRFYSRDTCAAAVDRFLLDGQQARLTQAALETLAVVAYRQPVSRSRVSAVRGVNCDGVMRTLVQRGLVEEAGSEPETGAILYRTTNYFLERMGLRGLDELPELAPFLPEVDDVEAESLEGTMIAEAVAAAAVQAADGSGEAGRATHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR7</accession>
    <name>A0A1E7NBR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288100.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79658">
        <property type="protein sequence ID" value="ARF79658"/>
        <property type="gene ID" value="B6264_12745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38132">
        <property type="protein sequence ID" value="OEV38132"/>
        <property type="gene ID" value="HS99_0023350"/>
    </dbReference>
    <dbReference type="OMA" id="MTWMPDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="8246" checksum="7369CD7772842098" modified="2017-01-18" version="1">MTWMPDRDDAPRGRRHNSPQRSAHRPDRADDLGFDGLDRRQRGVQRQMGIRRILGRRARWVGARLRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY8</accession>
    <name>A0A1E7NBY8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyldiaminopimelate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386879.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene468"/>
    <dbReference type="EnsemblBacteria" id="ARF78846">
        <property type="protein sequence ID" value="ARF78846"/>
        <property type="gene ID" value="B6264_07885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38168">
        <property type="protein sequence ID" value="OEV38168"/>
        <property type="gene ID" value="HS99_0023570"/>
    </dbReference>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="382" mass="41187" checksum="DC360F3BF4D6BD03" modified="2017-01-18" version="1">MSTNSTRAPFPGHPGAARRVSDRLPVFPWDKLEPYKATALAHPGGLCDFSVGTPVDPVPEVIQKALAAHTDTPGYPTVWGPLELREAIAGWLHRRCGAEIGPRAVLPTVGSKELVASLPTQLGLGPGDQVAYPRLAYPTYEVGARLCGAEPVEYDSVDELDGSRVRLLWVNSPSNPTGRVLGTDELRRAVEWAREHRVLLVSDECYFELGWEAEPVSVLHPDVCGGDHEGLLAVHSLSKRSNLAGYRASFVAGDPVVVAELLGLRKHGGMIVPAPVQAATIAALTDDAHVAEQRERYAARRSALRAALEAYGFRVEHSEASLYLWATQDRPCWETVAELAALGILVAPGDFYGPSGDRFVRVAFTATDERVAAAVERLAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC75</accession>
    <name>A0A1E7NC75_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysM</name>
        <name evidence="8" type="ORF">HS99_0022385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284077.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000103.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4193"/>
    <dbReference type="EnsemblBacteria" id="ARF80196">
        <property type="protein sequence ID" value="ARF80196"/>
        <property type="gene ID" value="B6264_15885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38287">
        <property type="protein sequence ID" value="OEV38287"/>
        <property type="gene ID" value="HS99_0022385"/>
    </dbReference>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="322" mass="34480" checksum="3C230DF6AE29F0F4" modified="2017-01-18" version="1">MRYDSPLEAVGNTPLVRLPRLSAAVPGNDGGLVNLWAKLEDRNPTGSIKDRPALHMIERAEADGRLTPGCTILEPTSGNTGISLAMAAKLKGYRMVCVMPENTSEERRELLRMWGAEIISSPAAGGSNTAVRIAKEISAEHPDWVMLYQYGNPDNAGAHYTTTGPEILADLPTVTHFVAGLGTTGTLMGVGRYLREKVPGVKIVAAEPRYDDLVYGLRNLDEGFVPELYDAEVLTTRFSVGSADAVRRTRELLQQEGIFAGISTGAILHAALGVGRRAAVAGERADVVFVVADGGWKYLSTGIYTAESTEAAVEALQGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCA8</accession>
    <name>A0A1E7NCA8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name evidence="2" type="ORF">HS99_0022640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283981.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4144"/>
    <dbReference type="EnsemblBacteria" id="ARF80155">
        <property type="protein sequence ID" value="ARF80155"/>
        <property type="gene ID" value="B6264_15635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38322">
        <property type="protein sequence ID" value="OEV38322"/>
        <property type="gene ID" value="HS99_0022640"/>
    </dbReference>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="18357" checksum="B2F0499160DC98E3" modified="2017-01-18" version="1">MAKETGQKLIAQNKKARHEYTILDTYECGLVLTGTEVKSLREGRANLVDGYAYIQNHEAWIDNVFIPEYTQGTWTNHAARRKRKLLLHKLEIRKIETKVRDAGHTLVPLSLYFKDGRVKLELALAVGKKLYDKRQTLREKQDTREAARAVAAARRRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC3</accession>
    <name>A0A1E7NCC3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0021890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3304"/>
    <dbReference type="EnsemblBacteria" id="OEV38340">
        <property type="protein sequence ID" value="OEV38340"/>
        <property type="gene ID" value="HS99_0021890"/>
    </dbReference>
    <dbReference type="OMA" id="ETVVMWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 6" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="8">
        <location>
            <begin position="3"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="510" mass="55210" checksum="25355F7207959F84" modified="2017-01-18" version="1">MPLARRTGVPQPVLMTLLGIVMALVPQIPNVEIQPALILPLVLPPLIFAVARRSSVRYFKANARSILLLAVALVVVTTIAVAGTVHWLLPALPLAAAIALGALVSPPDPVAAVAVAGSIGLPRRLVAILESEGLFNDVTAIVIYSLSIEAMVSGDFSVGDAALRFVLSAVLAVVVGVGLGWVNARLAERLDDPTQQVALNLLVPFAAYTLAEEIHGSGVLAVVICALYLAERAADADAVSYRLVGNAFWEVVEILITGVAFGLIGLELATVLAEAGRGWTGFLGDAAVVIAVVVLVRLLWLLPAGWLSKKVRKGDDEDTPFSWKESVVLWWSGMRGVATVALALAIPLTLHSGADFPERGRLVFIAFSVVLFTLLVQGLTLPWLAKRLKLDIDQDRHEQAVRELWWRAAKAGLKRLGELEEQDRLPAELADRLRDRQHDRLARLCPEKYAEEEAAEARQRLAQWRAAAEVEQEMIAASRREMLAARSELGADPELVDQVLRGLDLRSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD3</accession>
    <name>A0A1E7NCD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386344.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82861">
        <property type="protein sequence ID" value="ARF82861"/>
        <property type="gene ID" value="B6264_16045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38351">
        <property type="protein sequence ID" value="OEV38351"/>
        <property type="gene ID" value="HS99_0022225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="10139" checksum="B1885F31F1E30A00" modified="2017-01-18" version="1">MQAQVRNPKTVKAAAYNQARSILAQAGSQTAAKSHPAHGTNDVPVSYGTSLLAAARDEFRAADKHLPAGQKKSDMSIPHYNAIHSAANTMGIDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE3</accession>
    <name>A0A1E7NCE3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388372.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4137"/>
    <dbReference type="EnsemblBacteria" id="ARF80148">
        <property type="protein sequence ID" value="ARF80148"/>
        <property type="gene ID" value="B6264_15600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38328">
        <property type="protein sequence ID" value="OEV38328"/>
        <property type="gene ID" value="HS99_0022675"/>
    </dbReference>
    <dbReference type="OMA" id="WQNQLRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="616" mass="65692" checksum="6B9A4CEF2278D303" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND36</accession>
    <name>A0A1E7ND36_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid:proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828739.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene638"/>
    <dbReference type="EnsemblBacteria" id="ARF77618">
        <property type="protein sequence ID" value="ARF77618"/>
        <property type="gene ID" value="B6264_00615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38591">
        <property type="protein sequence ID" value="OEV38591"/>
        <property type="gene ID" value="HS99_0020200"/>
    </dbReference>
    <dbReference type="OMA" id="WVSARYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="552" mass="58464" checksum="DD13CA514ABE465F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND40</accession>
    <name>A0A1E7ND40_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">HS99_0021060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283203.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene268"/>
    <dbReference type="EnsemblBacteria" id="ARF82207">
        <property type="protein sequence ID" value="ARF82207"/>
        <property type="gene ID" value="B6264_27995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38403">
        <property type="protein sequence ID" value="OEV38403"/>
        <property type="gene ID" value="HS99_0021060"/>
    </dbReference>
    <dbReference type="OMA" id="YGHERFA"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="36750" checksum="4D42B9ABB49CC3ED" modified="2017-01-18" version="1">MRIGVLTSGGDCPGLNAVIRSVVHRGVVDHGDEIIGFEDGWRGFLEGHHRPLTLDSVSGILAQGGTILGSSRVQPSHLRDGVERARQYCSDLGLDAVIPIGGEGTLKAAKLMSDAGLPIVGVPKTIDNDIAATDVTFGFDTAVSVATEALDRLKTTAESHQRVMVVEVMGRHTGWIALNAGMAAGAHAIVVPERPFHIEKLTAVVRERFDRQKKFAIVVCAEGAKPEPGTMHWEEGTKDIYGHERFTGIATQLSRELEHRLGKEARPVILGHTQRGGTPTAYDRVLATRFGWHAVEAVHKGAFGHITALQGTKINLVPLAEAVAELKTVPQERYQEAETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD5</accession>
    <name>A0A1E7NDD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551475.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene631"/>
    <dbReference type="EnsemblBacteria" id="ARF82536">
        <property type="protein sequence ID" value="ARF82536"/>
        <property type="gene ID" value="B6264_00655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38712">
        <property type="protein sequence ID" value="OEV38712"/>
        <property type="gene ID" value="HS99_0020240"/>
    </dbReference>
    <dbReference type="OMA" id="YEGPGYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14311" checksum="CD5BBE33AD0E2A8D" modified="2017-01-18" version="1">MPFFVYGTLRSGGRNHAVHLAGRCDGILPAVLDGAALHDGPGYPYAVPDATPGRRIVGELVTVRPGAYAGVLADLDRLEDCRADGTGLYLRRRMAVRTAAGERREAWVYLAGPAAAARLRARPALIASGDWTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDF6</accession>
    <name>A0A1E7NDF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0020395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281149.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000383.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene599"/>
    <dbReference type="EnsemblBacteria" id="OEV38717">
        <property type="protein sequence ID" value="OEV38717"/>
        <property type="gene ID" value="HS99_0020395"/>
    </dbReference>
    <dbReference type="OMA" id="FITNGTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="387" mass="41078" checksum="FF3413F60ABDC0B4" modified="2017-01-18" version="1">MNLELSEEQSAVRDLAAAFTDREVVPYAAEWDRAESVDRAIIGKLGKVGFLGLTIPEEYGGSGGDHLSYCLVLEELGRGDSAVRGIVSVSLGLVGKSINGFGTEEQKRHWLPRLTSGEALACFALTEPGTGSDAANLTTRAVRDGDDWLISGAKMFITNGTWADVALVFARTGGSDPEQRGHRGITAFLVPTDLPGFGRTEVHGKLGLRGQATAELALNDVRVPDSARLGEVGKGFTVAMAALAKGRMSVAAGCVGIARACLEAAVRYAGEREQFGKPIASHQLVQELLAGIAVDVEAARLLTWKVADHIERGLPFATESSVAKLYASEAAVRAANNALQVFGGYGFIDEYPVGKYLRDARVMTLYEGTSQIHQLLIGRALTGVNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG9</accession>
    <name>A0A1E7NDG9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene687"/>
    <dbReference type="EnsemblBacteria" id="OEV38698">
        <property type="protein sequence ID" value="OEV38698"/>
        <property type="gene ID" value="HS99_0019950"/>
    </dbReference>
    <dbReference type="OMA" id="HATRFAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="550" mass="60787" checksum="8AAB14DEA6BAB897" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDS1</accession>
    <name>A0A1E7NDS1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556313.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5120"/>
    <dbReference type="EnsemblBacteria" id="ARF81242">
        <property type="protein sequence ID" value="ARF81242"/>
        <property type="gene ID" value="B6264_22165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38839">
        <property type="protein sequence ID" value="OEV38839"/>
        <property type="gene ID" value="HS99_0019430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="15329" checksum="24BC3996521B9617" modified="2017-01-18" version="1">MVPRTNQTDRVTEPGDPGGRTLATLRVAPGWNPWLSRLVIDVFGTVDEYEMTLTEHVLRVHELTPVFGDPGRQVYAIPRKEAAQRLVRVKHDTRMSVFWFLEPGRGKPTRMSVRHQWRHGFDAFTAALGAQAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC7</accession>
    <name>A0A1E7NFC7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3506"/>
    <dbReference type="EnsemblBacteria" id="OEV39193">
        <property type="protein sequence ID" value="OEV39193"/>
        <property type="gene ID" value="HS99_0000220"/>
    </dbReference>
    <dbReference type="OMA" id="MSHESPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="32677" checksum="0442263AFF92FE87" modified="2017-01-18" version="1">MNSDDRTTIGPVTGSGDGGHGRPGGRAARRAAAQRHQGRGRRGRRRGGFVPVTAVVAAVAGTGLLAALAGAGYAAFDGKQSDRDLAGQAAAADSLVAAELGTHDGIQVPGTGGTNPSGSALPAGSPTATGPAATPSATATETAGATASASPTAAPTATATASARPTATAKASPTATRTGANGAGATAQRAAAAPAAAPAGGGPNTSYAQQVVDLVNGERAKAGCGPVSAEPRLASAAQSHSDDMADRNYFDHASPEGYHADHRIEATGYRWSTWGENIARGQKDPAAVMDAWMNSPGHRANILNCSFTQLGVGVRTGANGPWWTQVFAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF8</accession>
    <name>A0A1E7NFF8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39440">
        <property type="protein sequence ID" value="OEV39440"/>
        <property type="gene ID" value="HS99_0001695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19405" checksum="C206011C9E094650" modified="2017-01-18" version="1">MRQAVNGAGRQARVALVASGTESLRGESAEEVVRRLQDEFTDLRRRMPSGPERTYRQELILAALVRLTPQLEEFDIAAALVSADGGTRLTAYARLYACPEGEFLPALVEAAAEEVLPFAQFWALHAIAAVIDAVGPDSVQLATVRRLRACLARIPQTAVDRIQSLRAILGRLEDAVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH9</accession>
    <name>A0A1E7NFH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556308.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39460">
        <property type="protein sequence ID" value="OEV39460"/>
        <property type="gene ID" value="HS99_0001810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7372" checksum="7D1DD956B255FE6B" modified="2017-01-18" version="1">MRPSDTGWQHLASAGHPVPAAPEEAPYCADLADGTVLALTGSRLTEPDAHLLRRSSRNCARRTSEATCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL8</accession>
    <name>A0A1E7NFL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556254.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5067"/>
    <dbReference type="EnsemblBacteria" id="OEV39496">
        <property type="protein sequence ID" value="OEV39496"/>
        <property type="gene ID" value="HS99_0002040"/>
    </dbReference>
    <dbReference type="OMA" id="GTHYNAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031221">
        <property type="term" value="P:arabinan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="PTHR39447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="SSF110221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199097" evidence="2">
        <location>
            <begin position="38"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="ArabFuran-catal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="AbfB" evidence="3">
        <location>
            <begin position="370"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="517" mass="53757" checksum="E6AF9629D4372217" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW4</accession>
    <name>A0A1E7NFW4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6729"/>
    <dbReference type="EnsemblBacteria" id="OEV39562">
        <property type="protein sequence ID" value="OEV39562"/>
        <property type="gene ID" value="HS99_0002460"/>
    </dbReference>
    <dbReference type="OMA" id="HLEAWER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25400" checksum="616F4C3FF3B8E830" modified="2017-01-18" version="1">MQHRSVGDVMTREVVTARPDTPFKEVAALFHRNDITAIPVIDDQGRPLGMVSEADLLRKEAVLPDPEGRFPGRRLDAGDRARAEAETAGGLMTSPAVTARPGWSVPEAARAMDKHRVKRLPVVDEAGRLVGIVSRRDLLEVFLRHDAAIRDEINHDVLGQTLWLTPGDVVVGVHEGVVTLRGRLPRRSLIPITEQLCRAVDGVVAVHAALDWTEDDTDPHLEHPRAYRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC8</accession>
    <name>A0A1E7NGC8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550471.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000659.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2896"/>
    <dbReference type="EnsemblBacteria" id="OEV39734">
        <property type="protein sequence ID" value="OEV39734"/>
        <property type="gene ID" value="HS99_0003505"/>
    </dbReference>
    <dbReference type="OMA" id="SIRPWFV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08589">
        <property type="entry name" value="PI-PLCc_SaPLC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032075">
        <property type="entry name" value="PI-PLC-C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16670">
        <property type="entry name" value="PI-PLC-C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199118" evidence="1">
        <location>
            <begin position="35"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="37802" checksum="94B91816F2308A2A" modified="2017-01-18" version="1">MTARRTTSGRTLAGLLAAGLLAGAAALVPSAAPAAADTGTGDLPFGSATTVGLHNTYDPAAYQYLAQSLDTGTGMVELDLWTDVITKEWKVSHSNPLGNSNNCTAADNPGQLYGGGTNKNLEHCLDDIRVWLGAHPAAGPLVVKLELKGGFAANMGMGPDQLDALIAAHLGDAVLRPADLLVKPGGGSYATVDEAVRAGNWPSRSALAGRVLLYAIPGTVEENNPFDTLHTDVEYGRHLRDLAAAGRIGQAQLFPAVHGAAAGDPRSKYTGADTGIRPWFVVFDGDAATYLNGIDTAWYDRSHYLVVMTDAQNVAPQISATDPTADQARARTEQLARAHASIVSSDWRKLPTVQSLVLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH6</accession>
    <name>A0A1E7NGH6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367069.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2898"/>
    <dbReference type="EnsemblBacteria" id="OEV39735">
        <property type="protein sequence ID" value="OEV39735"/>
        <property type="gene ID" value="HS99_0003515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27964" checksum="E0DBFD0367363E35" modified="2017-01-18" version="1">MLEVLGAHIAVPAAIGVQVTELDRDTYRFVHHPGRRRTRTAAHRSTARRRASRAARAASATVRSGTDGIVAGRGGGKHMVKAAADDGAGGPEQPGERAAAIARRLDRLMAREAARSGGRPPAYRELADRINRLAGRDVISRDTVRNLHLGLNQKGQACNPTVDTLDWLGRGFGIGAGASYFLDDAKAAVVDEQLEQLERVAELRQALGNDGVVNLAKRASALSDGSLRVLLSLADNLRKLEQDAAEDGPVGQDGRHTTPADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH9</accession>
    <name>A0A1E7NGH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0001540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene553"/>
    <dbReference type="EnsemblBacteria" id="OEV39819">
        <property type="protein sequence ID" value="OEV39819"/>
        <property type="gene ID" value="HS99_0001540"/>
    </dbReference>
    <dbReference type="OMA" id="HRSTLRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="341"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="507"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="574" mass="63150" checksum="9BC14E8C74A17E4F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV1</accession>
    <name>A0A1E7MVV1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0040110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000090">
        <property type="protein sequence ID" value="OEV32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7122"/>
    <dbReference type="EnsemblBacteria" id="OEV32556">
        <property type="protein sequence ID" value="OEV32556"/>
        <property type="gene ID" value="HS99_0040110"/>
    </dbReference>
    <dbReference type="OMA" id="EFNDNPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="48054" checksum="E3BEFFD0DCFB2FD1" modified="2017-01-18" version="1">MRSHQPDRRTDPAAAPAATRAVRPGPGPRSGTALALQRSIGNAAVTRLVQRTRHGADGSGRSGGSGCSSSARGSSSAGCSGEHGELPLQRSLVHQVLRTVGQPLDATTRHEMECRLGADFSDVRLHTGSTARASAAEVGARAYTSGNHVVLGAGGGDRHTLAHELTHVIQQRSGPVAGTDRGDGLRVSDPSDRYEREAEANAVRALAAPLVHAGAEAGPGYASRTPGAAEAPVQRMPPKRKAEAAELSEPSGRTTRGKARAANLDLNRPVLEFTSEYEGPATQRLDDAQSIGFQQVARLRNPPGAPQQVATNYHFWQEVKDSNVQIVRSGTDFPATPSSRPWMQDGPYRPPYNNAVINNAQNMIEFNDNPGFSTSARMTAGYWLRSYQVSFRWKVAHAAGPWSRTMPAWTSPEVTHTLHSEFDPEHPDQPSPIVASPAGDFTWNVDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW46</accession>
    <name>A0A1E7MW46_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554899.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3138"/>
    <dbReference type="EnsemblBacteria" id="ARF78309">
        <property type="protein sequence ID" value="ARF78309"/>
        <property type="gene ID" value="B6264_04705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32650">
        <property type="protein sequence ID" value="OEV32650"/>
        <property type="gene ID" value="HS99_0015375"/>
    </dbReference>
    <dbReference type="OMA" id="LEMRASW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23067" checksum="0710910A9976410D" modified="2017-01-18" version="1">MAAVGGHPAQGGGTGGGTGREGAPSEFRAAMEALEGARLRPEVQLSPAPAPRRLAPYSFAVTAAVEVDGEELADGRLVLLYDPAGQEAWNGEFRVVTMTRAELEPEMAGDPMLSEVGWAWLLDALQAHGAGYAEPSGTVTRCASQYFGGLADRPSSTEIEIRASWTPADGRFERHLAAWGDLLCISAGLPPTSPAPQGPNEVTSLGGVVPMPARRRPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW62</accession>
    <name>A0A1E7MW62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554910.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3149"/>
    <dbReference type="EnsemblBacteria" id="OEV32661">
        <property type="protein sequence ID" value="OEV32661"/>
        <property type="gene ID" value="HS99_0015430"/>
    </dbReference>
    <dbReference type="OMA" id="YEICATE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33559" checksum="9FE011DEFDAB137D" modified="2017-01-18" version="1">MTTTALTIRDFRPQDAEAVAAAHRAGREHLVMTAEALLWLNARQDSDQHFRTFVAELDGRVVGGVRCGLVLGTSTTGVGYANGSVLPGFRRRGAATALLAAAERHLSGHGVTEMHTWLDDEPASLAFAAARGYRLGRTAQFGARDLTLPLPQAPVRPAGVELRPGTDWADDPRPLFLVEADAIRDEPGEVAMDALEYEEWLRADWARPDLDLGLITVAVVDGVPAAFTMVQTDGVDRYWSAFTACRREFRGRGLARLAKLESLRLAAAAGYRRAYTSNDTTNAPMLAVNSWLGYERCAGERKGIKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW78</accession>
    <name>A0A1E7MW78_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1 2">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name evidence="3" type="ORF">HS99_0015560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288289.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3176"/>
    <dbReference type="EnsemblBacteria" id="ARF78277">
        <property type="protein sequence ID" value="ARF78277"/>
        <property type="gene ID" value="B6264_04525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32685">
        <property type="protein sequence ID" value="OEV32685"/>
        <property type="gene ID" value="HS99_0015560"/>
    </dbReference>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1 2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28177" checksum="75E6D2D0B99A383D" modified="2017-01-18" version="1">MTERLPLMAGNWKMNLNHLEAIQHTQKLAFALADKDYEAVEVAVLVPFTDLRSVQTLVFGDKLKIKYGSQDISQHDGGAYTGEVSGPMLAKLQCTYAVIGHSERRQYHGENEEIVNAKVKAAYRAGVTPILCVGEPLEIRKAGTHVEYTLAQLDGALEGVTADQAESIVVAYEPVWAIGTGEVATPEDAQEVCAAIRRRIAELYDAELADKVRVLYGGSVKSSSAAGLMAKPDIDGGLIGGASLDADEFVKIVRYREQAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW93</accession>
    <name>A0A1E7MW93_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32533">
        <property type="protein sequence ID" value="OEV32533"/>
        <property type="gene ID" value="HS99_0017505"/>
    </dbReference>
    <dbReference type="OMA" id="RMAVYDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18581" checksum="385DC4F12EFE27B6" modified="2017-01-18" version="1">MAGVSPHYDEVFAEVAQRARLSGSLGKADIAVLTVWKRLSARTPWAAVLMSRPDAEVRAVTARAVAAVRDTALPRGEAARAGRAVLGQLPGLRTGDALASAVLTAAAPGRMAVYDRRVQAALDALGFTLTPAPGRYGRYLRLLDGLLLHGGPRADGWTARDLDTALYWAGGNGPQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC9</accession>
    <name>A0A1E7MWC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285518.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000387.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7829"/>
    <dbReference type="EnsemblBacteria" id="ARF78221">
        <property type="protein sequence ID" value="ARF78221"/>
        <property type="gene ID" value="B6264_04190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32738">
        <property type="protein sequence ID" value="OEV32738"/>
        <property type="gene ID" value="HS99_0015895"/>
    </dbReference>
    <dbReference type="OMA" id="GVVWDFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="40815" checksum="823C4769B97182BB" modified="2017-01-18" version="1">MSLHRARSAAFAAVLTAAALSLTACGSAGSSSAKAGSNDLAGGKSAKTATSVADFGGMDALVAAAKKEGKLHVITLPRDWANYGKLMDDFKAKYGIDIEDENPDGSSQDEINAITSRKGQDRAPDVVDLGSAFAISAGKQGLLAPYKVTDFDKIPATMKDANGLSYNDYGGYMSIGCDAKKVSACPKTFADLLKPDYKGMVALNGNPTKAGAAFGAVYAAALANGGSLDNIQPGIDFFGKVKQAGNFNPVEVTPATIEKGETPISIDWSYLNAGYSDKFKDKGIDWQVSIPSDGSYAQYYNQAINKDAPHPAAARLWEEYLYSAQGQNGFLGGYATPALFDAMKTAGTLDATAAAKLPTVEKPFTTFPTQDQTDAAKKVVTENWAKAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF8</accession>
    <name>A0A1E7MWF8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385426.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7814"/>
    <dbReference type="EnsemblBacteria" id="ARF78206">
        <property type="protein sequence ID" value="ARF78206"/>
        <property type="gene ID" value="B6264_04110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32749">
        <property type="protein sequence ID" value="OEV32749"/>
        <property type="gene ID" value="HS99_0015970"/>
    </dbReference>
    <dbReference type="OMA" id="GYGLFWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="45587" checksum="1FFF2AAC5EE4E8F2" modified="2017-01-18" version="1">MYVADSRSSKAPVAPAAGQVRRGAALRAVPGTVLALGTVSMVTDVSSEMVNAVLPLYLLTGLGLSPLGFGLLDGIQNGFSALVRLVGGHLADRRGRDGAARHKAVAAVGYGLSALCRPLLLFVHTVPLIGAVIAVDRTGKGLRTAPRDAMISLATEPAHRGRAFGVHRAMDTAGALLGPLTAFLVLRLAGGPMLADGGERHGYDAVFTVSACVAALGVLILLLFVPTRQEGDDPSNTAPSLRGSLTLLRLPGLRRLTGCAVLLGLTTVSDSFLYLLVQRRLGLSVNLFPLLPLGTAAAFLLLAVPLGSLADRVGRRRLFLLGHGVLLLAYGLLLSPLRGLPAVLCVLVLHGSFYAATDGVLAAAAADAVPAEQRGAGLALVGTGQALARFACSLLFGALWSALGGPTALAWSAGALALCVAGAAVVLRSPGTVAADSTVAADAAEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWH7</accession>
    <name>A0A1E7MWH7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonyl-CoA carboxylase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6101"/>
    <dbReference type="EnsemblBacteria" id="ARF78186">
        <property type="protein sequence ID" value="ARF78186"/>
        <property type="gene ID" value="B6264_03990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32769">
        <property type="protein sequence ID" value="OEV32769"/>
        <property type="gene ID" value="HS99_0016090"/>
    </dbReference>
    <dbReference type="OMA" id="DFNCWGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043880">
        <property type="term" value="F:crotonyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010085">
        <property type="entry name" value="Crot_CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01751">
        <property type="entry name" value="crot-CoA-red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="445" mass="48881" checksum="5DF771F59C71C0AF" modified="2017-01-18" version="1">MQEILDAILSSDATSADFAALKLPESYRAVTLHKDEEQMFAGLDSRDKDPRKSLHLDEVALPELGPGEALVAVMASSVNYNTVWSSIFEPVSTFGFLERYGRLSPLTKRHDLPYHVLGSDLAGVVLQTGAGVNAWKPGDEVVAHCLSVELESPDGHNDTMMDPEQRIWGFETNFGGLAQIALVKTNQLLPKPKHLTWEEAASPGLVNSTAYRQLVSQNGAGMKQGDNVLIWGASGGLGSYATQYALAGGATPICVVSSEAKADICRAMGAEAIIDRSAEGYKFWKDENNQDPREWKRLGSKIREFTGGEDVDIVFEHPGRETFGASVYVTRKGGTIVTCASTSGYMHQYDNRYLWMSLKRIVGSHFANYREAFEANRLVAKGKIHPTLSKVYTLEETGQAALDVHHNKHQGKVGVLCLAPEEGLGVRDHELREKHLPAINRFRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWL2</accession>
    <name>A0A1E7MWL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6095"/>
    <dbReference type="EnsemblBacteria" id="ARF82605">
        <property type="protein sequence ID" value="ARF82605"/>
        <property type="gene ID" value="B6264_03960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32818">
        <property type="protein sequence ID" value="OEV32818"/>
        <property type="gene ID" value="HS99_0016120"/>
    </dbReference>
    <dbReference type="OMA" id="WLPTDFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="32398" checksum="14BE343B1F13BFF3" modified="2017-01-18" version="1">MLDLVTALRYVDPLRAGGSVPGVVETDDLGTYVVKFTGAAQGRKALVAEVIVGELARRLGLRVPELRLVDFDPVVAADEPDTEIQDMLKASAGLNLGMDLLPGAADYRPGMIRVDSAEAGRVVWLDALTGNVDRTVHNPNLVVWHGRLWLIDNGAALIFHHRWATAEASVGKRYDLSAHALGACAPDVRLADEDLGPLVTVELLEQVVALVPDEWLAGEPGFDSVDAVRRAYVTHLAARAVLSEAWLPEGFATAEQLREAELRRAARTRAGRPAWLQEVPDLHGKPSVETVWEHHFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ1</accession>
    <name>A0A1E7MWQ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphomannomutase/phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0039735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene81"/>
    <dbReference type="EnsemblBacteria" id="ARF80123">
        <property type="protein sequence ID" value="ARF80123"/>
        <property type="gene ID" value="B6264_15420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32860">
        <property type="protein sequence ID" value="OEV32860"/>
        <property type="gene ID" value="HS99_0039735"/>
    </dbReference>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="49207" checksum="789BD9ED21C7C204" modified="2017-01-18" version="1">MRDLKQLVKAYDVRGVVPDQWDESLSRAFGAAFVQVTGASAIVVGHDMRPSSPSLSRAFAEGAAAYGADVVQIGLCSTDQLYYASGKLDLPGAMFTASHNPAQYNGIKLCRAGAAPVGQDTGLSEIRELVESWTAEDDTVTVPARDVEPGALSEQDTLRGYADHLLGLVDLTSIRPLKVAVDAGNGMGGHTVPTVFDGLPIELVPMYFELDGTFPNHEANPLDPKNLVDLQAKVREVGADVGLAFDGDADRCFVVDERGEPVSPSAITALVAAREIARAQAAGETEPTIIHNLITSWTVPEVVRELGATPVRTRVGHSFIKQEMAVTDAVFGGEHSAHYYFRDFWRADTGMLAALHVLAALGGQERTLSELTAEYDRYAASGEINSTVADQAASTAAVRAAYAGLEGTTMDELDGLTVAGPDWWFNLRASNTEPLLRLNVEAKDPARMAELRDGVLAVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ2</accession>
    <name>A0A1E7MWQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289945.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000399.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene83"/>
    <dbReference type="EnsemblBacteria" id="ARF80121">
        <property type="protein sequence ID" value="ARF80121"/>
        <property type="gene ID" value="B6264_15410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32858">
        <property type="protein sequence ID" value="OEV32858"/>
        <property type="gene ID" value="HS99_0039725"/>
    </dbReference>
    <dbReference type="OMA" id="RTPMFGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018953">
        <property type="entry name" value="AMP_nucleoside_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10423">
        <property type="entry name" value="AMNp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16933" checksum="E852637EC274D2EF" modified="2017-01-18" version="1">MDSSAPQSSTGPSRRPRHRDRHGRGLRGPLAPPQVPISLTRSELFDDYVRESVERLERRWPQLIEVEFAVQEVPLHEADGADSEDGVPLGRVSPGEKGRKSQIVVYRRPVEIRAKTREDRAALVHEILIEQVAELLGLSPDAIDPRYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX03</accession>
    <name>A0A1E7MX03_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS_1_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0013940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5732"/>
    <dbReference type="EnsemblBacteria" id="OEV32976">
        <property type="protein sequence ID" value="OEV32976"/>
        <property type="gene ID" value="HS99_0013940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026032">
        <property type="entry name" value="HcaT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004925">
        <property type="entry name" value="HcaT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="382" mass="40216" checksum="8A928089D2BAFF33" modified="2017-01-18" version="1">MWLSARFFLFFLTWSSYLSYWGVWLLASGFGPTEVTAIITAGLVSRSISIAVVFPMLCRTIPLRRLSQLLAWTATALSPLYLTHPQFGSMLAVSVLVGISYPLLMPLSETLATIGAANGQVDYGSVRYFGSAGFLFGLCVSGVVGRLAGSGALVGVFVVGCLLLAVADVVSPVGFPTVTTVASGGRVRLLRNRVYTLGLGSSVLLQGAHAAYYAFGAEYFSRLGVSSINVSLMLALAVGCELLLFKYAGPLLGGYPVPVLFAAAAAISVLRWGLLAVPMPLAFVVLTQTLHAGTFALTHLAHARCVQSHVPEDLWPNAQALYAGLAIGLGVAAVTAVTGPLYTASPHWAFLAMAVVCLPCFLLVRLQVKVLRDEAAVPDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX43</accession>
    <name>A0A1E7MX43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0014135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385422.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81426">
        <property type="protein sequence ID" value="ARF81426"/>
        <property type="gene ID" value="B6264_23165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33008">
        <property type="protein sequence ID" value="OEV33008"/>
        <property type="gene ID" value="HS99_0014135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15832" checksum="25028E43260EC3F5" modified="2017-01-18" version="1">MTTAPVLGAGIIVPTGDGRVLVGRRTTTGEPPTWSLPGGKVDPGESFERTAARELAEETGIVLPAEAMRVLAVHLDHELGRPRLTAAVLAPPSLAEAVVTEPHACAGWERFPVDALPEPMFYPSALVLGSWLPGLDGVRREGTHGYPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXP4</accession>
    <name>A0A1E7MXP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0039215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7100"/>
    <dbReference type="EnsemblBacteria" id="OEV33218">
        <property type="protein sequence ID" value="OEV33218"/>
        <property type="gene ID" value="HS99_0039215"/>
    </dbReference>
    <dbReference type="OMA" id="NDRAERY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20172" checksum="2E17D54C309C1423" modified="2017-01-18" version="1">MEAAARVIARRGVRGLRVEELAAEAGVSTALIYYHFKDRTGILRQTLEFINDRAERYTTERAADAPPLTAREELEQTLLLELQETVEVRENSTAWGELRASAVFDETLREDLARATRVWVQEIAGLLGAVRPMSSAVALAGAAERLTALLEGLSTRWLSGSLPLAHARTLMADAIDAEVTRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT4</accession>
    <name>A0A1E7MXT4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558094.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000070.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene527"/>
    <dbReference type="EnsemblBacteria" id="OEV33258">
        <property type="protein sequence ID" value="OEV33258"/>
        <property type="gene ID" value="HS99_0039015"/>
    </dbReference>
    <dbReference type="OMA" id="WETILSF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="234"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35992" checksum="8C084EE1782FBA98" modified="2017-01-18" version="1">MLRIHFGTDDLDRVRVAERPDMSMELSLSVHALVSGRCDPRFQVWRNRLRASWNPRTALLFDLYTRSAIPEFLTVRRDPGAIESATAGTPEEPLRDHLLSVGGERELSAFARGVAAGDQRARKLLGNVTADYQTRAIDPYRRQIETIVTTEHGRRRRIAEPDQVLGSLHPALAWRRPVLSFPLSSGCRRDVRLDGRGLLLQPCVFGPRRPVIARFEDPHQQPVLLYPARISGPLQPETEPTPSRTLTALLGQTRAAALEAIATHGPCSTKDLATHVDISTASASEHATVLADSGLTTKDRTGRTVTHRPTPLGQALLAGHLPTPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY60</accession>
    <name>A0A1E7MY60_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="7" type="ORF">HS99_0012370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553467.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4013"/>
    <dbReference type="EnsemblBacteria" id="ARF80482">
        <property type="protein sequence ID" value="ARF80482"/>
        <property type="gene ID" value="B6264_17595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33380">
        <property type="protein sequence ID" value="OEV33380"/>
        <property type="gene ID" value="HS99_0012370"/>
    </dbReference>
    <dbReference type="OMA" id="MIYLDSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15406" checksum="1F203165B9B7930D" modified="2017-01-18" version="1">MIYLDSCALLKLLVTETESAALRTFLSSHGSEGHATSALAQVEVPRALIRVGAPQQVLDAAADLLDRVLRVRLSDPVLRAASRFPTRHPRTLDAIHLASAEHLEHALTAFVTYDKRLAEAADERDLPVTAPGWVPGAEPGGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYM7</accession>
    <name>A0A1E7MYM7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-dextrin endo-1,6-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
            <ecNumber evidence="5">3.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pullulan 6-glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0013420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.</text>
            <dbReference type="EC" id="3.2.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EC" id="3.2.1.41" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549964.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5233"/>
    <dbReference type="EnsemblBacteria" id="OEV33550">
        <property type="protein sequence ID" value="OEV33550"/>
        <property type="gene ID" value="HS99_0013420"/>
    </dbReference>
    <dbReference type="OMA" id="TREQFYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10315">
        <property type="entry name" value="CBM41_pullulanase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005323">
        <property type="entry name" value="CBM41_pullulanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011839">
        <property type="entry name" value="Pullul_strch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024561">
        <property type="entry name" value="Pullul_strch_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040671">
        <property type="entry name" value="Pullulanase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045041">
        <property type="entry name" value="Pullulanase_PULA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43631">
        <property type="entry name" value="PTHR43631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11852">
        <property type="entry name" value="DUF3372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03714">
        <property type="entry name" value="PUD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17967">
        <property type="entry name" value="Pullulanase_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02103">
        <property type="entry name" value="pullul_strch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198568" description="Alpha-dextrin endo-1,6-alpha-glucosidase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="9">
        <location>
            <begin position="70"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1843" mass="195893" checksum="614E50D8179EB802" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ16</accession>
    <name>A0A1E7MZ16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737975.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4929"/>
    <dbReference type="EnsemblBacteria" id="OEV33661">
        <property type="protein sequence ID" value="OEV33661"/>
        <property type="gene ID" value="HS99_0038410"/>
    </dbReference>
    <dbReference type="OMA" id="EAGVWGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043737">
        <property type="entry name" value="DUF5682"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18934">
        <property type="entry name" value="DUF5682"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="731" mass="76972" checksum="8A9E44AD18EA461F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ59</accession>
    <name>A0A1E7MZ59_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000169.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4290"/>
    <dbReference type="EnsemblBacteria" id="ARF82873">
        <property type="protein sequence ID" value="ARF82873"/>
        <property type="gene ID" value="B6264_16835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33701">
        <property type="protein sequence ID" value="OEV33701"/>
        <property type="gene ID" value="HS99_0038365"/>
    </dbReference>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="49128" checksum="C87FE17D79A8C945" modified="2017-01-18" version="1">MEVPTVAQAPAVKQRPGSTRTLLKGVDGAGTVRRSVLPGGLRVVTETLPTVRSATFGIWVGVGSRDETPQLNGATHYLEHLLFKGTERRSALDISAALDAVGGEMNAFTAKENTCYYARVLDTDLPLAIDVVCDMLTGSLIRPEDVDAERGVILEEMAMAEDDPGDVVHDLFAKVIYGSGPLGRPILGTQETIKALTRDQIAGFYHRRYRPENLVVAAAGNLDHRKVVKQVERAFAPVLARSTAAPAEARRGIKALRTAGKVEVLNRSTEQAHLVLGVPGVPRHDERRWAMGVLNAALGGGMSSRLFQEVREKRGLAYSVYSYSSSYADSGLFGIYAGCQPKRVEEVLRICREELAKVVADGITEEELQRAIGQISGSTVLGMEDTGSLMNRIGKAELSYGHHLSVDDMLERIAAVTLEDVHAVARDVLGAYRPSLALIGPVNDKRAAKLADLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ60</accession>
    <name>A0A1E7MZ60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366696.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000222.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1922"/>
    <dbReference type="EnsemblBacteria" id="ARF79620">
        <property type="protein sequence ID" value="ARF79620"/>
        <property type="gene ID" value="B6264_12495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33717">
        <property type="protein sequence ID" value="OEV33717"/>
        <property type="gene ID" value="HS99_0038230"/>
    </dbReference>
    <dbReference type="OMA" id="DSEGGHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21468" checksum="71A4D531C0F3839C" modified="2017-01-18" version="1">MTEIDGATLATAELAPRFSLTPDGPRAGRLDGAWWPRSHDLPFELPALAAELNKRWGRVAGITVNPAQWLTVPRRIPIAGRTVHVSHTVHAGGFTAVQDQHTISVRSHLARRLTLLVVPPRTGAVEAARLMAEAADPANTGTASELLAEEPSARVSDRRGIIWPVRDPSVSAWGSARWGGPLSPGCSGLCPRPTTDGADHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ65</accession>
    <name>A0A1E7MZ65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385453.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1929"/>
    <dbReference type="EnsemblBacteria" id="OEV33724">
        <property type="protein sequence ID" value="OEV33724"/>
        <property type="gene ID" value="HS99_0038190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15106" checksum="1A0D5E5E30DF2F36" modified="2017-01-18" version="1">MSTAVHHHRHLAFAAGSGASSVNEGRAFTRRALADWRLTCSTTGDDAQLVASELLTNAVRHTAGPLAMDLDDDGSRLRITVTDPRADITPPDPGSHQPARIGGHGLFIVDRLALHWGAFPEGCGKTVWADLLLRGRATDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N015</accession>
    <name>A0A1E7N015_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77895">
        <property type="protein sequence ID" value="ARF77895"/>
        <property type="gene ID" value="B6264_02220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34037">
        <property type="protein sequence ID" value="OEV34037"/>
        <property type="gene ID" value="HS99_0011370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="6422" checksum="27F6C132E9545770" modified="2017-01-18" version="1">MNISTLLRGRTGRTGRTSRTGRIVAATATAVLTAAGLGISAAGTASAAETGRDTPQSLNGITYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N023</accession>
    <name>A0A1E7N023_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0011390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551806.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000320.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2289"/>
    <dbReference type="EnsemblBacteria" id="OEV34040">
        <property type="protein sequence ID" value="OEV34040"/>
        <property type="gene ID" value="HS99_0011390"/>
    </dbReference>
    <dbReference type="OMA" id="QNHMYNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="23850" checksum="3CFD9AF255997314" modified="2017-01-18" version="1">MTPLRPSPLAGQAADLIEQRIRAGEWPVGGKLPGEVALAKELGVGRSTVREALRTLAAAGMVHSRQGSGVFVTADRPAAGDWTTRLRAAELAHVYEVRTMVEVQAARLAAERRTATDLAAVDAALAARLAAGGADDTAFVDADIALHTAIVAAAHNPVLDDLFAQFAPVLREHLVALVGLFGLREGDPNQGYASHAELVRALHDGDPAAAGRVLATELESTRARLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N065</accession>
    <name>A0A1E7N065_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77938">
        <property type="protein sequence ID" value="ARF77938"/>
        <property type="gene ID" value="B6264_02470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34079">
        <property type="protein sequence ID" value="OEV34079"/>
        <property type="gene ID" value="HS99_0011615"/>
    </dbReference>
    <dbReference type="OMA" id="CEADPWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="11336" checksum="DCFDCECDD64828E1" modified="2017-01-18" version="1">MVTVHAIRFHLRAPDRPDGPPTSTPGAVHDGLARGLPAPARIEHARILTGPGTVDGVAFVLADNLLAAEAALAAACATLTGPTGPLPHWDVPHCALDTLLALGLHELPACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N088</accession>
    <name>A0A1E7N088_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366484.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2352"/>
    <dbReference type="EnsemblBacteria" id="ARF77954">
        <property type="protein sequence ID" value="ARF77954"/>
        <property type="gene ID" value="B6264_02560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34094">
        <property type="protein sequence ID" value="OEV34094"/>
        <property type="gene ID" value="HS99_0011705"/>
    </dbReference>
    <dbReference type="OMA" id="YGQHESA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2289" mass="240501" checksum="0B22DC27E22788D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T1</accession>
    <name>A0A1E7N0T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2590"/>
    <dbReference type="EnsemblBacteria" id="OEV34285">
        <property type="protein sequence ID" value="OEV34285"/>
        <property type="gene ID" value="HS99_0036740"/>
    </dbReference>
    <dbReference type="OMA" id="SVITTHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021459">
        <property type="entry name" value="GH101-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11308">
        <property type="entry name" value="Glyco_hydro_129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198640" evidence="1">
        <location>
            <begin position="26"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="660" mass="69590" checksum="0B8DCC1FBE4BE13C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N152</accession>
    <name>A0A1E7N152_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557823.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7209"/>
    <dbReference type="EnsemblBacteria" id="ARF79224">
        <property type="protein sequence ID" value="ARF79224"/>
        <property type="gene ID" value="B6264_10130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34405">
        <property type="protein sequence ID" value="OEV34405"/>
        <property type="gene ID" value="HS99_0035950"/>
    </dbReference>
    <dbReference type="OMA" id="EPGRMKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29195" checksum="498B55946FA06BE0" modified="2017-01-18" version="1">MNGTITPSTQYLDVPGGRLAYDDTRQGAGTPVVLLPGMLDSRRAYRHLHPLLTVAGRRVITMDLRGFGESSIVWDDYSPSAVATDVLALLDHLGIERAVLVGQSYTGATVVKLAGDAPQRVAGIALIDAFVEQRANALMKGVMAVMGAAMVRWPAVWGYYLRKMAFPGPRPADLDTYVDGLVAALHTPGRRTATRGHVNGDSAPIGWSAAVRCPALVLMGSKDPDFPRPEAVADLQAEKLGARKIMIEGSGHYPMADNPQAVADALLPFLAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N167</accession>
    <name>A0A1E7N167_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tam</name>
        <name evidence="2" type="ORF">HS99_0035620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:14969"/>
            <dbReference type="ChEBI" id="CHEBI:15708"/>
            <dbReference type="ChEBI" id="CHEBI:57470"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.144"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. Tam family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290688.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1079"/>
    <dbReference type="EnsemblBacteria" id="ARF78965">
        <property type="protein sequence ID" value="ARF78965"/>
        <property type="gene ID" value="B6264_08575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34438">
        <property type="protein sequence ID" value="OEV34438"/>
        <property type="gene ID" value="HS99_0035620"/>
    </dbReference>
    <dbReference type="OMA" id="YLAFADH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00560">
        <property type="entry name" value="Tran_acon_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023506">
        <property type="entry name" value="Trans-aconitate_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28458" checksum="3E9AD59FA12E9D35" modified="2017-01-18" version="1">MTSPVWDPAQYLRFADERTRPLRDLLARVPALPNEPAATILDIGCGPGNSTAVLRERWPQARITGVDNSAPMLATARTEGEPTADYLLADARDYDPAPAGPDLIASNATLQWVDGHLAVLARWADALRPGGVLAFQVPGNFDAPSHTLLAELRRSPRWRDTLGADAVRSGVHPPGRYLDALAGAGCAVDVWETTYSTLLPGPDPVLEWVKGTALRPVLGRLTDQADRAAFLAEYGRLLREAYPAGPHGTVFPFRRIFAVGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F1</accession>
    <name>A0A1E7N1F1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7075"/>
    <dbReference type="EnsemblBacteria" id="OEV34501">
        <property type="protein sequence ID" value="OEV34501"/>
        <property type="gene ID" value="HS99_0035475"/>
    </dbReference>
    <dbReference type="OMA" id="FKSEAHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="29684" checksum="F1ED5B297C0DA067" modified="2017-01-18" version="1">MIADGGPPSLILSLQERGTALKEQDGRESVVRPGELPITDTSRVFRKKMEEGFVFASFHFPRAALDVSERDLRALTATPFSGTEGSAALVATYLSRLAREAEVLDEAAGRRAAATALDLLALLVDDRSRRSRPQAPRSAASLERVKAHILRNLRDPDLSPSTIAEANFMSVRFLHKLFQREGTTVGGWIRTQRLERCSRDLLRPVAAELGVAGIARRWGFANSSHFSRAFRAAYSMTPRDWQVGGEPARCPSVARDTSAPGGRRSGTRTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U0</accession>
    <name>A0A1E7N1U0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554675.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000831.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4233"/>
    <dbReference type="EnsemblBacteria" id="ARF81976">
        <property type="protein sequence ID" value="ARF81976"/>
        <property type="gene ID" value="B6264_26580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34659">
        <property type="protein sequence ID" value="OEV34659"/>
        <property type="gene ID" value="HS99_0009200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="11953" checksum="081C4DD4A9F16088" modified="2017-01-18" version="1">MNIIGEGLGDTTAVRFGCQPAASFTVLNDQEVLAVSPNLVTDVEIDATPGQLTTRTVGRFYYLPDSVLAGISPTSGPLSGGGTLTVTGRGLITTHRCALAPSLSPHRPSWTTRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A3</accession>
    <name>A0A1E7N2A3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0010115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556961.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3212"/>
    <dbReference type="EnsemblBacteria" id="OEV34817">
        <property type="protein sequence ID" value="OEV34817"/>
        <property type="gene ID" value="HS99_0010115"/>
    </dbReference>
    <dbReference type="OMA" id="YLAVWRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20625" checksum="696E396AFAFD87FE" modified="2017-01-18" version="1">MRSRRRALDELDEERLVRLVARGDRGAFDELYRRTSPWLAVRLRRRCADEQIVAEVMQETYLAVWRAAGAFAGSAVGGTAVGWLWTIAARRLVDAFRRRAHHAEPPVAAAERAVVPAAEDEALAKAVGGEVGDALRRLAPELRAVLQATVLDGLSVRETAVLLRLPEGTVKTRARRARIAMREALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J2</accession>
    <name>A0A1E7N2J2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737934.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4212"/>
    <dbReference type="EnsemblBacteria" id="ARF81963">
        <property type="protein sequence ID" value="ARF81963"/>
        <property type="gene ID" value="B6264_26495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34673">
        <property type="protein sequence ID" value="OEV34673"/>
        <property type="gene ID" value="HS99_0009285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="16017" checksum="E6CB173896ECFFFF" modified="2017-01-18" version="1">MSPILLALVPSQGPTTGGNPVLLVGTGLTGATAVLFGTTPALSFTVQFDGAITAVAPPGTGTVPVKVVTPAGTSNTLSYTYQLPAPPTILALVPPIGLAVGGLPVLIVGHGLSGATAVLFGTTPATNFTVLGDGAILAVSPPGTGTVPVTVITPAGTSNGASYTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P4</accession>
    <name>A0A1E7N2P4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5855"/>
    <dbReference type="EnsemblBacteria" id="ARF77555">
        <property type="protein sequence ID" value="ARF77555"/>
        <property type="gene ID" value="B6264_00205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34940">
        <property type="protein sequence ID" value="OEV34940"/>
        <property type="gene ID" value="HS99_0034895"/>
    </dbReference>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="47936" checksum="CA511F8485F4F4D3" modified="2017-01-18" version="1">MSQPLADAVRSLMDRARTDLAELVAFPSVADPRQFPVEECQKAAQWVADAFAAEGLGNIQLLDTPDGTQSVYGELPGPDGAPTVLLYSHYDVQPPLDENAWLSPAFELTERDGRWYGRGAADCKGNILMHLTALRALRQVYGDGYPVGLKIIVEGSEEQGTGGLERYAEAHPELLAADVIVIGDTGNFAPGLPTVTTSLRGMTVVEASVTTLAGNLHSGAFGGAAPDALQSLVRMLASLHDENGDVAVAGLAADQTWEGVQYPEEQFRTDARVVDGVELTGTGTVADRLWARPSVTVLGIDAPPVIGATSSVQAAAKALISLRVPPGMSSDAAQDALVAHLEAQVPLGARLTIQRQGNGAPFRADTDGPAYEAMGEAMAEAFGTPMVTAGEGGSIPLCNTLRSLYPQAEIVLIGVEEPTTQIHAVNESVDPQELERMALTEALFLRRYAELRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z4</accession>
    <name>A0A1E7N2Z4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpx</name>
        <name evidence="4" type="ORF">HS99_0034560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284770.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000148.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4736"/>
    <dbReference type="EnsemblBacteria" id="OEV35057">
        <property type="protein sequence ID" value="OEV35057"/>
        <property type="gene ID" value="HS99_0034560"/>
    </dbReference>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="17342" checksum="7EE02FD818A74CA3" modified="2017-01-18" version="1">MAQVTLKGNPVEVGGALPAVGSQAPAFTLVGEGLVDTSLKDFAGRRKVLNIFPSIDTPTCATSVRTFNAKAGALENTVVLCISADLPFAQARFCGAEGLENVKTLSTLRGRDFHDSYGVSINDGPLAGLTARAVVVLDENDTVLHTELVAEIAEEPNYEAALAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z6</accession>
    <name>A0A1E7N2Z6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35050">
        <property type="protein sequence ID" value="OEV35050"/>
        <property type="gene ID" value="HS99_0034525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6682" checksum="0BDA11193A45D46C" modified="2017-01-18" version="1">MPSSLFEPLWDQLSALFPKRPEFDPNHPLGCHELLLRGGQVVLVVLEPGDFFHGRTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N312</accession>
    <name>A0A1E7N312_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA mismatch repair protein MutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386552.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000402.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene435"/>
    <dbReference type="EnsemblBacteria" id="OEV35070">
        <property type="protein sequence ID" value="OEV35070"/>
        <property type="gene ID" value="HS99_0033945"/>
    </dbReference>
    <dbReference type="OMA" id="EHDELRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="16061" checksum="9B7FA875A6F761E4" modified="2017-01-18" version="1">MEQTGRTPDATPLRIVVGGALIRDGRVLAARRSAPAPVAGRWEFPGGKAEPGETEAQTLERELLEELGVRARALRRLPGAWTVRPGLELRFWAAELLAGEPSPLADHDELRWLGAAELDSVDWIEHDREVLPHVAELLAPADDAQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L9</accession>
    <name>A0A1E7N3L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552907.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000130.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4732"/>
    <dbReference type="EnsemblBacteria" id="OEV35053">
        <property type="protein sequence ID" value="OEV35053"/>
        <property type="gene ID" value="HS99_0034540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="18374" checksum="F65C1CD246E8A099" modified="2017-01-18" version="1">MTEPNADPEHILDDLLAGRPGILELTRALTSAEPRSFRPLLADEDRSSPYDLDGLDDYEREQVRRGALLVLADDFVDETEWGGDDIAVGFRRADDFSEDFEELVTLISAHYGEAVENADELRYSDSGKAAYWRAGESTLVLQVFVNYPGGNIELHLWLAAIADQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3V6</accession>
    <name>A0A1E7N3V6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550599.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000218.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35379">
        <property type="protein sequence ID" value="OEV35379"/>
        <property type="gene ID" value="HS99_0032725"/>
    </dbReference>
    <dbReference type="OMA" id="CCGCHVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="39894" checksum="B8E49300BC975817" modified="2017-01-18" version="1">MLTLGVEEEYLLVDPRDGMPLPRAAEVLATASLAPALRPAEAQHELLQVQVESATPVCEDLAGVARHLARVRAGLNAAAAQHGCRVVPVGSAPFGPPGPVPVTDAERYRRAHRQAPALVDDLMLNGMHVHVGVRDEEERLGALVRLRPWLPVLIALSANSPYWRGADTRFASWRTVQFDQWAVSGPPPAFRDAADYRQRVAALRTAGAVADAGQLYWHARLSERYPTVEVRAADVQLTVADAELFAGLVRALVTTAVLEERQGRPRPRTPEELLRAATWHAARTGLHGQLVSPADGTARPAAAVVEELRAYLAPGLEAAGDTGRVAELWREFDRTGNGADRQRRWYREQGWAGLAEHLVGSTVTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N488</accession>
    <name>A0A1E7N488_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0031925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5509"/>
    <dbReference type="EnsemblBacteria" id="OEV35508">
        <property type="protein sequence ID" value="OEV35508"/>
        <property type="gene ID" value="HS99_0031925"/>
    </dbReference>
    <dbReference type="OMA" id="MNSVPQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="28889" checksum="704C9846D8ABBE58" modified="2017-01-18" version="1">MNGVPMSNPPPLHAEDRPEYERLLGEALRDRTVLTALRAPGALTADQLRVLALRDADTVNTAAGTEYAHYTALRESLRATPPPPADVEPYAPGLLSQLRSTNGGAGLFPVLTVLTPILAWSAGLVLLLVGYLLRAVDSGLLLGRSMVTAGWVALAAGVAAMAVGVVGLLLTAIRDGAAAVPAGTDPELAAELAAARAEWRTALRERGLLPYLHTRLPAVPGRPAPGFTGPGYSPPAFTSPGPDGLTGADGRTPRPAAFTTPDFTGPGYTPPDFTGPDDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P7</accession>
    <name>A0A1E7N4P7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551150.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene909"/>
    <dbReference type="EnsemblBacteria" id="ARF80862">
        <property type="protein sequence ID" value="ARF80862"/>
        <property type="gene ID" value="B6264_19855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35668">
        <property type="protein sequence ID" value="OEV35668"/>
        <property type="gene ID" value="HS99_0007085"/>
    </dbReference>
    <dbReference type="OMA" id="KVDVCYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="31814" checksum="2C0DE1836240AA32" modified="2017-01-18" version="1">MDTMRERFVDVTTRLLDEDPRLAVVLADITAAAFEPARERHPDRVVNVGIREQLLIGAAGGLALSGMRPIAHTFASFLVERPFEQLKLSLVHQGVGAVLVSAGGSYDNPAAGRTHMSPGDVALLDTLPDWTVHVPGHPEEAEQLLRHAVADGDRNVYVRLSNHQNAAPVPVEPGRFATVRTGSRGVVLAVGPMLDAVLAATEGLDVTVLYAATVRPFDTAGLRAALGERTDVVLVEPYLEGTSANEAHAALADHPHRVLALGVPRGEHRHYGSMAEHLAAYGLDAASLKERIATFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X5</accession>
    <name>A0A1E7N4X5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278190.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5504"/>
    <dbReference type="EnsemblBacteria" id="ARF79402">
        <property type="protein sequence ID" value="ARF79402"/>
        <property type="gene ID" value="B6264_11140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35513">
        <property type="protein sequence ID" value="OEV35513"/>
        <property type="gene ID" value="HS99_0031950"/>
    </dbReference>
    <dbReference type="OMA" id="NVDHICL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14565" checksum="44D8E1734AE0A80C" modified="2017-01-18" version="1">MRVVALDHLVLNVADIERSLAFYTGLLGLEPVRVEEWRAGKVSFPSVRVSPGTIIDLFDRPRHESNVDHICLTVEPLDWQEVVDSGVFTVLDGPGPRYGARGTGTSLYVQDPDGNTVELRWYPQDAGEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N556</accession>
    <name>A0A1E7N556_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3362"/>
    <dbReference type="EnsemblBacteria" id="ARF81046">
        <property type="protein sequence ID" value="ARF81046"/>
        <property type="gene ID" value="B6264_20970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35836">
        <property type="protein sequence ID" value="OEV35836"/>
        <property type="gene ID" value="HS99_0008190"/>
    </dbReference>
    <dbReference type="OMA" id="HVCPRQN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20582" checksum="642CD4B6B5C963ED" modified="2017-01-18" version="1">MPRQVFFYDQPERFVAGTVGQPGARAFYLQASARGRVTSVLLEKNQVAALAERIEEVLDEALRRSGGDAAIPAAAPKDLLDTAPLDLPLEQEFRVGTMALAWDSVDACLVVEAQALVEDEEEDGEEAVFRDDEDGPDMLRVRLTGAMARVFAKRALDLVAAGRKPCPFCNLPLDPEGHLCPRANGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N576</accession>
    <name>A0A1E7N576_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0008250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286114.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3349"/>
    <dbReference type="EnsemblBacteria" id="ARF81057">
        <property type="protein sequence ID" value="ARF81057"/>
        <property type="gene ID" value="B6264_21030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35845">
        <property type="protein sequence ID" value="OEV35845"/>
        <property type="gene ID" value="HS99_0008250"/>
    </dbReference>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="34740" checksum="81818B4164FF7E22" modified="2017-01-18" version="1">MSEPTGAARRRGPFQVGDQVQLTDPKGRHYTFTLQAGNQFHTHKGAFPHDELIGAPEGTVVRTTGNVPYLALRPLLPDYVLSMPRGAAVIYPKDAGQILAMADIFAGARVVEAGVGSGALSTYLLRAVGEQGSLASYERRQDFADIARGNVERYFGGPHPAWKLTVGDLQDNLVETDVDRVILDMLAPWECLDVASKALVPGGLICCYVATTTQMSKTVEALRDHGTFTEPQAWETMVRTWHLEGLAVRPDHRMIGHTGFLLTARRLADGVEPPLRRRRPAKGAYGEDYDSGAPEPTLQERAAARKASRGAEDEQPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N592</accession>
    <name>A0A1E7N592_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286150.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7239"/>
    <dbReference type="EnsemblBacteria" id="ARF81074">
        <property type="protein sequence ID" value="ARF81074"/>
        <property type="gene ID" value="B6264_21125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35861">
        <property type="protein sequence ID" value="OEV35861"/>
        <property type="gene ID" value="HS99_0008345"/>
    </dbReference>
    <dbReference type="OMA" id="RPNQRAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042204">
        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="11159" checksum="CAE73271F3874513" modified="2017-01-18" version="1">MTRRRTPAALVEADPGPAHRIEFDGRPVRALPGQSIAAALWADGVLAWRTTRVGGRPRGAFCGIGACFDCLATVNGRANQRLCLLPAEPGTVVTTQEGHGRADLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D4</accession>
    <name>A0A1E7N5D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281775.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene915"/>
    <dbReference type="EnsemblBacteria" id="ARF80856">
        <property type="protein sequence ID" value="ARF80856"/>
        <property type="gene ID" value="B6264_19825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35663">
        <property type="protein sequence ID" value="OEV35663"/>
        <property type="gene ID" value="HS99_0007055"/>
    </dbReference>
    <dbReference type="OMA" id="LPNWHPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15973" checksum="8DDF699BC400B1CE" modified="2017-01-18" version="1">MAVLTVSTVVEAPAERVWELVGDFHALGDWHPHLPPSRLGNGLAGNAIGSVRVFELPDGVVLHETLLAYDDEARSYTYSFPDGTFHFDGYRATLRVTPVTELAASFVEWSVRYDIEAEHRKDSTERVHGVFTTGLAGLRERFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5S0</accession>
    <name>A0A1E7N5S0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7247"/>
    <dbReference type="EnsemblBacteria" id="OEV35994">
        <property type="protein sequence ID" value="OEV35994"/>
        <property type="gene ID" value="HS99_0008390"/>
    </dbReference>
    <dbReference type="OMA" id="ALMYQIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="32345" checksum="D5BAF3DFC8D7B86E" modified="2017-01-18" version="1">MDRAFVLERGIPVSTEQQAKRSVTVIGLGPMGHAMAGAYLDAGYAVTVWNRTAARADELVARGARLAPGAEAAVAANELVVLSLTDYDAVFAVLESVEGAVAGKVIANLSSDTPARAREAARWLTERGAGHLTGGVQVPPSGIGSPESSTFYSGPVELFNRHRAALEVLTGADFRGDDPGLAQLYYQIQMDLFWTSMAGYLHATAIAEANGISAEEFLPYLSSTAASMPGFQAFYAPRITAGNHAGDVDRLAMALASIEHVRHTAEASGVDDALPAVLAEAFRRGVESGRGAASLTALVGQFRRAQLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V7</accession>
    <name>A0A1E7N5V7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4962"/>
    <dbReference type="EnsemblBacteria" id="OEV36086">
        <property type="protein sequence ID" value="OEV36086"/>
        <property type="gene ID" value="HS99_0030930"/>
    </dbReference>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="237"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="56261" checksum="853F7F1D388B3FFD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N632</accession>
    <name>A0A1E7N632_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5020"/>
    <dbReference type="EnsemblBacteria" id="ARF80083">
        <property type="protein sequence ID" value="ARF80083"/>
        <property type="gene ID" value="B6264_15195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36138">
        <property type="protein sequence ID" value="OEV36138"/>
        <property type="gene ID" value="HS99_0031215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="506" mass="52482" checksum="597577403A02CED9" modified="2017-01-18" version="1">MGESAAAKAVQKVTGMWWPDADPDKLRTVADAWEAMATAIDNVTAPTNQAAAAIVANNHGPAIDAFGKFWARYYGGKDSAGKGKGWLPETADACRALAKALRDFAHEVDKAIKKLEEEAAIVGGTLVVGAALAIVTFSISADIAAATAAGIVATAAAVGVTVSEAIATIAATVLVGAAFGAVEAITVDLAVAQPIRVELFGDGGYSLTEAADSAETGGIMGGAGGGLGAGARVVTTAAETTENASVALAGLAKVANAADTVPGRMITGAGLTYGYDTAFKTGPVMPLDLVLGAVGSAAGPRARSTESAPYVPRHAKPVELPMPGRLPPREYVEAHPSVAKVTTELARVPPKVFNHVWDYLKAAPGGGISIGPRPITELPGGFHLAGVKPVGGSAPAEHVPGMYLPTERRLLIDSSANTKSSVAVHEFGHAVDEAYGFKSRQPDWQHVQQQVLDRIGGNPKLDAYTRQPHEFFAEAFNHWTAKKLTKFTFGDREAAKILKEYFERAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N692</accession>
    <name>A0A1E7N692_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome C biogenesis protein ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284262.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8061"/>
    <dbReference type="EnsemblBacteria" id="ARF79825">
        <property type="protein sequence ID" value="ARF79825"/>
        <property type="gene ID" value="B6264_13750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36212">
        <property type="protein sequence ID" value="OEV36212"/>
        <property type="gene ID" value="HS99_0030695"/>
    </dbReference>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="26849" checksum="BD6C0154ACD1D757" modified="2017-01-18" version="1">MSAPLQLADNTATLQSGALLVAAPIAVAAGLVSFFSPCVLPLVPGYLSYVTGFSAADLADARGARRGRMLLGAVLFILGFTAVFVSSGALFGQFGGTLKEHQRVISTVLGAVTIVMGLAFMGLVPGLSMREVRTHRRPVIGLLGAPLLGVVFGVGWTPCMGPTLATVSNLALNQADAQRGALLMTFYCLGLGVPFIVAALAFRRALGAFGWVKRHYPLVMRIGGGMLVAVGLLLVTGIWDSWMSELQSWTADSQIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E7</accession>
    <name>A0A1E7N6E7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8090"/>
    <dbReference type="EnsemblBacteria" id="ARF82816">
        <property type="protein sequence ID" value="ARF82816"/>
        <property type="gene ID" value="B6264_13605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36248">
        <property type="protein sequence ID" value="OEV36248"/>
        <property type="gene ID" value="HS99_0030550"/>
    </dbReference>
    <dbReference type="OMA" id="MQLLGAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="368" mass="39261" checksum="024306C0E69BE4E9" modified="2017-01-18" version="1">MGVVVLVTGVARHLGARFAAEVRRRPGVDRVVGVDVQPPRLPVEEPDGPAAPYTFHQLDLRRPAVSRVIAEHRVDTVVHLSVSATGLGSTNRSAVKESNVIGTMQLLGACQKASGVRRLVVKSTTGVYGSAPRDPAVFSERMQPKDPPGGGFAKDAAEVEGYVRGFARRRPDVAVTVLRFANIVGPGADTPLSEYFALPVLPTVLGYDPRLQFVHEDDAVAVLCRAVDEPEPGTVNIGTFNVAGEGVLLLSQCARRLGRPTVPLLLPAISWMASLARQTRLVDVSPEQLRLLTHGRVVDTARLREVFGYRPAFTTPEAFADLAAAQGPGLLPPERLSAVTDRLAALLGPEAPAAVTAAVPNRPHRPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M5</accession>
    <name>A0A1E7N7M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPOX class F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387164.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000709.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2451"/>
    <dbReference type="EnsemblBacteria" id="ARF81537">
        <property type="protein sequence ID" value="ARF81537"/>
        <property type="gene ID" value="B6264_23845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36707">
        <property type="protein sequence ID" value="OEV36707"/>
        <property type="gene ID" value="HS99_0028560"/>
    </dbReference>
    <dbReference type="OMA" id="LAICDMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14833" checksum="11663AF1033D5D5F" modified="2017-01-18" version="1">MTTPDPAASDRLARIVSLSAGSYLLVTTYKKDGTPVPTPVWVVRDGEALGIWTVTDSWKVKRIRNRADVLVGPCDVKGNPTGGQYPATAEILGPERTAAYRTLLRQKYGLLGVLTLLGSRLRRGERGTVGIRITLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Q5</accession>
    <name>A0A1E7N7Q5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81501">
        <property type="protein sequence ID" value="ARF81501"/>
        <property type="gene ID" value="B6264_23610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36674">
        <property type="protein sequence ID" value="OEV36674"/>
        <property type="gene ID" value="HS99_0028320"/>
    </dbReference>
    <dbReference type="OMA" id="ASWGQND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="530" mass="55471" checksum="699C451C5C95F8FE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F1</accession>
    <name>A0A1E7N8F1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557255.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000468.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene159"/>
    <dbReference type="EnsemblBacteria" id="ARF81754">
        <property type="protein sequence ID" value="ARF81754"/>
        <property type="gene ID" value="B6264_25195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36975">
        <property type="protein sequence ID" value="OEV36975"/>
        <property type="gene ID" value="HS99_0003820"/>
    </dbReference>
    <dbReference type="OMA" id="LYWHFKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="24155" checksum="B290C8817A24000B" modified="2017-01-18" version="1">MTPKRTPKLDRAQVVDAALRLLDQVGLDGLTLRAIASELDVKAPALYWHFKDKQALLDEMATEMMRRMTAGATAAGGDRPERDGDWRALYLTTMRTLRAELLRHRDGAKVYSGARFTDTSYAAGLDASLRVLTEAGFTLAAATRAWYTAYSYTVGYVIEEQAMAPNPFDGDEGYDVEARAERLAAHPLAAEAGRVMFQDFDEGFEQGLAAVLAGVEATLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F3</accession>
    <name>A0A1E7N8F3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0027115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287020.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6827"/>
    <dbReference type="EnsemblBacteria" id="ARF78620">
        <property type="protein sequence ID" value="ARF78620"/>
        <property type="gene ID" value="B6264_06575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36934">
        <property type="protein sequence ID" value="OEV36934"/>
        <property type="gene ID" value="HS99_0027115"/>
    </dbReference>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="393" mass="40506" checksum="5D42FECCDCF890A4" modified="2017-01-18" version="1">MPYLDHAATTPMLPEAIAAMTAHLGVVGNASALHAAGRRARRVVEESRESLAESLGARPSEIVFTGGGTESDNLAVKGLYWSRRGADPARTRVLSSPVEHHAVLDAVHWLSEHEGATVEYLPVDGYGRVHPAELRAAIERDPASVALVTVMWANNEVGTVQPVRELAAVAAEYGIPMHADAVQALGQVPVSFAESGLTALTVTGHKIGGPFGIGALLLSRGATPVPLLHGGGQERDVRSGTLDAPAAAGFAAAAAWAVEHRAEHAVTLGALRDELVAGVLAAVPDAVLNGDPAAEGRLPANAHFSFPGCEGDALLMLLDAQGIECSTGSACSAGVPQPSHVLLAMGVDPLLARASLRFSLGHTSVREDVTALTAAIGPAVQRARNAGLVTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H2</accession>
    <name>A0A1E7N8H2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="10" type="ORF">HS99_0027255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286967.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6799"/>
    <dbReference type="EnsemblBacteria" id="ARF78596">
        <property type="protein sequence ID" value="ARF78596"/>
        <property type="gene ID" value="B6264_06440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36954">
        <property type="protein sequence ID" value="OEV36954"/>
        <property type="gene ID" value="HS99_0027255"/>
    </dbReference>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="36028" checksum="5BB26C4ABF84A756" modified="2017-01-18" version="1">MAELFYEDDADLSIIQGRKVAVIGYGSQGHAHALSLRDSGADVRVGLKPESKSRAKAEEAGLRVVTPAEAAAEADVIMILVPDPIQADVYEADIAPHLKAGDALFFGHGLNIRYGFIKPPADVDVCMVAPKGPGHLVRRQYEEGRGVPAIVAVEQNASGKAFELALSYAKGLGATKAGVIKTTFTEETETDLFGEQAVLCGGTAALVKAGFETLVEAGYQPEIAYFECLHELKLIVDLMYEGGLEKMRWSVSETAEWGDYVTGPRIITDATKAEMKKVLAEIQDGTFAKTWIAEYKAGLPKYNEYKKADEDHLLETTGKKLRSLMSWVNEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R1</accession>
    <name>A0A1E7N8R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556105.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000918.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7428"/>
    <dbReference type="EnsemblBacteria" id="ARF81657">
        <property type="protein sequence ID" value="ARF81657"/>
        <property type="gene ID" value="B6264_24595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37072">
        <property type="protein sequence ID" value="OEV37072"/>
        <property type="gene ID" value="HS99_0004400"/>
    </dbReference>
    <dbReference type="OMA" id="YRPHDQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28043" checksum="BEE613B4EFCC6F4C" modified="2017-01-18" version="1">MLLPSTQAGRGRPVVLLHARPTDRTMWNAHLPLLAEAGVRAIALDLPGHGDATVPDRRVVAPWSDVLDTLDHLGADRFVLAGNSLGALVALQVAVTAPERVDGLALVGYRPHDQPASPRLDAAWEAERTALAAGDLEAAVKAGVEAWTSTGATEEVRTHAARMLHRQLTEQLTHGEPPQATDPLGTGPAPLRALRGVAALVGVGEHDMPDFHEGGESLARDLGAGRITVIPDAGHLAPLEQPAVFCTLLLDFVRRLPQQSSPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T4</accession>
    <name>A0A1E7N8T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366245.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6679"/>
    <dbReference type="EnsemblBacteria" id="ARF81622">
        <property type="protein sequence ID" value="ARF81622"/>
        <property type="gene ID" value="B6264_24375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37107">
        <property type="protein sequence ID" value="OEV37107"/>
        <property type="gene ID" value="HS99_0004615"/>
    </dbReference>
    <dbReference type="OMA" id="WIRTANC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="42311" checksum="F7622E98B7488F6C" modified="2017-01-18" version="1">MAGRRVSFASMAADPVVDTPGVDSPRSGSPGSAVPGDTPARWIRTANCLPNPRNPRDDLGDLSDLASIKDRQLQSCLAVTPAAYLRLWPEDRQALGAGPDDVVVINGNRRRAAAQLYGREQLLVVVDDSVAESKATLLRAALDENMARKDFDPIEEANAVLLIVAQYPTAKEAAEAEGWSQSWISHRKNLLKLHPELQRQVRAKARGEEGVSINVARRLGSVKGIEEMSLAEQTAQLEQLLQADADAVAARRAAKLEAKAAAPQAAAPVVTPTPVPAPTPASTPTPTPTPASAPAPAPTPTPAADRSGPAPRSPQPTNPEPAPSADRFSAENSEPRPMPEQRAVAPVDEEPTPAAPQPGLGNVDWHNVEELADAICRTLSADEAYRLADALANRLLTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W3</accession>
    <name>A0A1E7N8W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000372.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6492"/>
    <dbReference type="EnsemblBacteria" id="ARF78648">
        <property type="protein sequence ID" value="ARF78648"/>
        <property type="gene ID" value="B6264_06735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36903">
        <property type="protein sequence ID" value="OEV36903"/>
        <property type="gene ID" value="HS99_0026950"/>
    </dbReference>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="412"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="619" mass="67359" checksum="F7C7AB5860CF1A0D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z0</accession>
    <name>A0A1E7N8Z0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0004860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556677.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6231"/>
    <dbReference type="EnsemblBacteria" id="ARF81581">
        <property type="protein sequence ID" value="ARF81581"/>
        <property type="gene ID" value="B6264_24130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37152">
        <property type="protein sequence ID" value="OEV37152"/>
        <property type="gene ID" value="HS99_0004860"/>
    </dbReference>
    <dbReference type="OMA" id="GYDITRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="38409" checksum="AEE3B1B5B55BAE02" modified="2017-01-18" version="1">MTGNDVVLALVITTGLGFDFTNGFHDTGNAMATSIVTGALRPRLAVAVSALLNLVGAFLSTAVAATIAGGLVNSHDVTLTVVMAGLTGSILWNLTTWFLGIPSSSSHALIGGVVGATMAAAGGSAVKWQGLVSKVIVPAALSPVIAGVVAALGTYLVYRLTRGVSEDSQRHGFRLGQIGSACMVSLAHGTNDAQKTMGVITLALIANGTLSAGAKSPTWVIASCAGAIALGTYIGGWRVIRALGKGLVEIDAPQGMTSESASAAVILSSTDFGYSLSTTHVATGSILGAGVGRKGAVVRWQIANRMVVAWLLTLPAAAVVGALAYWGADGIGGTAGVVAIDVVLVLAAIAFYAASRHPAVTPENVNAAWTGSVVPRAARRSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N971</accession>
    <name>A0A1E7N971_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fasciclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555227.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000318.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1329"/>
    <dbReference type="EnsemblBacteria" id="OEV37242">
        <property type="protein sequence ID" value="OEV37242"/>
        <property type="gene ID" value="HS99_0005420"/>
    </dbReference>
    <dbReference type="OMA" id="RINNANV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198986" evidence="1">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="22013" checksum="D12E2D3BDC23AAE6" modified="2017-01-18" version="1">MSTTTRRRNTVAALLTATALAVSLGACSSSGSGSSAATKAAAAVPSTAPGSTAPGSAASGTAMDDQPFGSACTAVPKDGAGSFAGMAKDPVATAASNNPLLSTLVTAVKQAGLVDTLNSAQNITVFAPTNDAFAKIPKATLDAVLADKDKLTKILTYHVVPQRLTPTALTGAHKTLETDDLTVTGTTPDFTVNTTAKVLCGNVQTANATVYIVDTVLMPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L3</accession>
    <name>A0A1E7N9L3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556374.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5398"/>
    <dbReference type="EnsemblBacteria" id="OEV37385">
        <property type="protein sequence ID" value="OEV37385"/>
        <property type="gene ID" value="HS99_0006300"/>
    </dbReference>
    <dbReference type="OMA" id="AGRDQHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="14754" checksum="78EEAFBD6772D947" modified="2017-01-18" version="1">MDPELIGLASAAATALVGRLAADGWEQAKRAVVALWRRSGRANEAEVVAGELEECRSELLASGQSEEGQAAAREMAIEWRGRLRGLLAAEPALAEELRALLTELRPDQPESGARVEMHGTASDQAKIYMSGGSMHISGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y9</accession>
    <name>A0A1E7N9Y9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287151.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7970"/>
    <dbReference type="EnsemblBacteria" id="OEV37499">
        <property type="protein sequence ID" value="OEV37499"/>
        <property type="gene ID" value="HS99_0026135"/>
    </dbReference>
    <dbReference type="OMA" id="HTDWLVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="2">
        <location>
            <begin position="159"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="33122" checksum="DD687F39DA1F72D3" modified="2017-01-18" version="1">MRERELLPEFFWAADAASLRGQRRAVLLSAWELALLLVAAATGSADGEPWAWPAAAGYLGAMALAVVISRQNPQGLWYEGRAAAESVKTLAWKFAVRADAYQPPPRSLPDAEGLYRFQLTRVLGAFRDGPVAVPANGIEITEAMRDLRGQPLAVRREVYLNERIRVQHDWYRSKARYCARAGYWTGVLGVLLPALGLALAVLRALGAFTYDALGTVSAVAASVTAWAQLRQYRPLAAAYGLAAEELELIRLQLARLDLESPDAEEIWARLARDAEDAVSREHTTWQARREVRTTTDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA82</accession>
    <name>A0A1E7NA82_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0025160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284184.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8022"/>
    <dbReference type="EnsemblBacteria" id="ARF79859">
        <property type="protein sequence ID" value="ARF79859"/>
        <property type="gene ID" value="B6264_13945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37605">
        <property type="protein sequence ID" value="OEV37605"/>
        <property type="gene ID" value="HS99_0025160"/>
    </dbReference>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="54331" checksum="0D4684CBF1A548B5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB55</accession>
    <name>A0A1E7NB55_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0023970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2086"/>
    <dbReference type="EnsemblBacteria" id="ARF79482">
        <property type="protein sequence ID" value="ARF79482"/>
        <property type="gene ID" value="B6264_11640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37930">
        <property type="protein sequence ID" value="OEV37930"/>
        <property type="gene ID" value="HS99_0023970"/>
    </dbReference>
    <dbReference type="OMA" id="DIGLFCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="42474" checksum="BF19D66238C4EAE5" modified="2017-01-18" version="1">MDRLVNTVRPYAWGSLTALPELLGQEPTGEPQAELWMGAHPGDPSRADRGEGPRRLDELIAADPEGELGAASTARFGPSLPFLFKVLAAGLPLSIQAHPTLDQARAGFATENALGLPLDAPERSYRDANHKPEMVCALGEFEGLCGFRRPAAAAALLAALAVPGLEPLIELLSVEDPGDDKAEAEALRGALAAVLTMDDATAERTVRETVAALAGTDPDGEHAPYARIAEDFPDDRGVIVGMLLNHVRLRAGEALYLAAGVPHAYLSGVCVELQANSDNVLRAGLTPKHIDVPELLKVVLFEPGAPEVVHPVRVDSTPGEQLYPVPIDEFRLSRFELDGVDREIDGRTPQIVLCTEGAVRLTAADGAVLDLARGQSAFLPATGTPTRLAGTGSTLFRATVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA5</accession>
    <name>A0A1E7NBA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278385.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000105.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2017"/>
    <dbReference type="EnsemblBacteria" id="ARF79541">
        <property type="protein sequence ID" value="ARF79541"/>
        <property type="gene ID" value="B6264_11990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37986">
        <property type="protein sequence ID" value="OEV37986"/>
        <property type="gene ID" value="HS99_0024310"/>
    </dbReference>
    <dbReference type="OMA" id="YWRKDAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="31140" checksum="76C28E131BC23FD3" modified="2017-01-18" version="1">MTLPTTHVSFPAGAVTGESQVLAVHPLADGRYAVVTESTPFHPLDHTWPDQPADHGTLTVDGTELAVVDCLTGAVGPDGGAPLVGAEIPVKRGDEEWSWLVLHVLAADPGDLTGRTAVLSVDAERRAALSASHSGCHLLALALNAALAPRWRKDPGRSDAFGNPDFDSLAMAASVMDTQASTDTYRLGKSLKKKGFTVDATEDFPALADALPALTEAVNARLAAWVAADAPVRIDVPGPELTARRQWHCELPEGGAQIFCGGTHLHHLGELAELRTELRLSEDGAELVAVTSPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE2</accession>
    <name>A0A1E7NBE2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000348.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2031"/>
    <dbReference type="EnsemblBacteria" id="ARF79528">
        <property type="protein sequence ID" value="ARF79528"/>
        <property type="gene ID" value="B6264_11920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37974">
        <property type="protein sequence ID" value="OEV37974"/>
        <property type="gene ID" value="HS99_0024245"/>
    </dbReference>
    <dbReference type="OMA" id="IEGPCHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="32373" checksum="8E6503D44684FFCB" modified="2017-01-18" version="1">MALSPHVPELGALELLLAVARLGSVGRAAAEVGVSQPTASARIKGMERQIGVPLLERSPRGSRPTEAGRLVVEWARQVVEAAQALDAGIDALRERRDAKLRVVASLTVAEYLMPGWLLALAEASPGTAVTLRTANSAEVAGHVLAGDADLGFVEGPTTPPGLAGAVVAADRLVVVVAPGHRWARRRAPLTGTELASTPLVLREPGSGTREVLEMALTPYGGAVPPRMELASSTALKAAAMTGAGPVCLSELAVVEELATRRLVEVPLAEELDLRRPLRAVWPAGQRPGGPARELLGLTRRSSGRPPRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE8</accession>
    <name>A0A1E7NBE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2066"/>
    <dbReference type="EnsemblBacteria" id="OEV38020">
        <property type="protein sequence ID" value="OEV38020"/>
        <property type="gene ID" value="HS99_0024065"/>
    </dbReference>
    <dbReference type="OMA" id="MTSQNMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042925">
        <property type="term" value="F:benzoate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004711">
        <property type="entry name" value="Benzoate_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30199">
        <property type="entry name" value="PTHR30199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03594">
        <property type="entry name" value="BenE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00843">
        <property type="entry name" value="benE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="40629" checksum="DC22C0202302F13F" modified="2017-01-18" version="1">MRPEQTAAGDGERRSLRRDASAPALLAGLVCVAVSFSGPLVVVLAAAAAGRLDPAHTASWIWAVAIGSGVSGFALSWWTRTPVVTAWSTPGAALLVTSLGGYPYREAVGAFLVSAAVVTLFGVTGWFGRLIAAVPVGIVNAMLAGILFSFGAGIFGAVHSAPVLVVGSFAAFLLAKRLAPRYAVPVALLVGGVLAALTVGLPLHLGTGGPTVPVLTVPAFSWSAVVGLALPLTIVVLASQNAPGLGVMRAFGYRADDRLLIGTTGLVSLLVAPFGSPGVNLAAITAAICSGPEAHPDPRRRYVAGMSSGAGYVLVGSFGGVLVSLFTGLPKELIAVIAGVALLASLQGSLAAAVAEERGRDAAVVTFLASASGMSLFGIGSAFWGLLFGLGTHLLLDLGKRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ0</accession>
    <name>A0A1E7NBJ0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="11" type="ORF">HS99_0022915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3041"/>
    <dbReference type="EnsemblBacteria" id="OEV38060">
        <property type="protein sequence ID" value="OEV38060"/>
        <property type="gene ID" value="HS99_0022915"/>
    </dbReference>
    <dbReference type="OMA" id="HTMAKVK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="10">
        <location>
            <begin position="53"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="9">
        <location>
            <begin position="247"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="48349" checksum="28DD231554546F5C" modified="2017-01-18" version="1">MIQHPVRSVRRAQSAAPARGRLQSLVPGRRRPRRIAMLSVHTSPLHQPGTGDAGGMNVYIVELAKRLAELNIEVEVFTRAICSDDAPTVELAPGVLVRHVTAGPYEGLVKEDLPAQLCAFTHGVLRTEAGHRPGHYDLVHSHYWLSGQVGWLAAQRWGVPLVHTMHTMAKVKNAALAEGDTPEPAARVIGETQVVEAADRLIANTTEEAAELALHYAARPDQLAVVHPGVNLDVFRPGGPRTAADARDRLGLPQDAAVLLFAGRIQPLKAPDVLLRAVAALLDRRPELRERLVVPVVGGPSGTGLARPESLHKLAAQLGIGDVVRFHPPVGQTRLADWYRAATALVMPSYSESFGLVALEAQACGTPVVAAAVGGLPVAVRDGESGTLVHGHDPLAWSHALEPYVTDRALVARRGAAAARHAAAFGWDTAAATTAEVYAGSMARPAGRLTGALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBN5</accession>
    <name>A0A1E7NBN5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288436.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000143.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene2998"/>
    <dbReference type="EnsemblBacteria" id="ARF79694">
        <property type="protein sequence ID" value="ARF79694"/>
        <property type="gene ID" value="B6264_12965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38097">
        <property type="protein sequence ID" value="OEV38097"/>
        <property type="gene ID" value="HS99_0023135"/>
    </dbReference>
    <dbReference type="OMA" id="KGHRHRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9397" checksum="A2DBE7F8A0616AF6" modified="2017-01-18" version="1">MTKHAAGSTAKFRQGTLDLLDRRGMATTPSRLGPKPRPGAVTAEAGHANGDTFRHIGRDVTPPGVHAAPPVQGELKGHRHRGAEKHSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC76</accession>
    <name>A0A1E7NC76_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553281.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4178"/>
    <dbReference type="EnsemblBacteria" id="ARF80183">
        <property type="protein sequence ID" value="ARF80183"/>
        <property type="gene ID" value="B6264_15815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38299">
        <property type="protein sequence ID" value="OEV38299"/>
        <property type="gene ID" value="HS99_0022455"/>
    </dbReference>
    <dbReference type="OMA" id="NIREVRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="21200" checksum="950E73D1E314D62E" modified="2017-01-18" version="1">MATDLSALAVKPTLHGPTVRLVPLDARHTDPMWELCTDRETNRLTGTRTTFTRDRIAQWCATRRDQPDRLDLAVEDPATGRFLGDTALTDVDPDNNSASYRIALTPDSTGRGIGTETTLLVLRHAFATVGLHRVHLEVFEYNERAARAYTKAGFVHEGRARQAHHWDDRYWDVLHMAALRDDWLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ1</accession>
    <name>A0A1E7NCJ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4154"/>
    <dbReference type="EnsemblBacteria" id="OEV38364">
        <property type="protein sequence ID" value="OEV38364"/>
        <property type="gene ID" value="HS99_0022585"/>
    </dbReference>
    <dbReference type="OMA" id="QDPAPIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="770" mass="79554" checksum="230A09C42055BB3E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP4</accession>
    <name>A0A1E7NCP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558054.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1741"/>
    <dbReference type="EnsemblBacteria" id="ARF80230">
        <property type="protein sequence ID" value="ARF80230"/>
        <property type="gene ID" value="B6264_16100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38253">
        <property type="protein sequence ID" value="OEV38253"/>
        <property type="gene ID" value="HS99_0022180"/>
    </dbReference>
    <dbReference type="OMA" id="GVETIRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="19140" checksum="2AAF1FF328F8D385" modified="2017-01-18" version="1">MIRRGRIHRIPAFAGLLALSLGSAVVTAAPAHASTAGINCTGWSYTTYAPGLTDTVRPTTVVVDGDLNVIDAHSPTGSCLSANSTATAGERDVTAQLDLSCNQLIGESGVETIRWNNGTTSSFPFTAAVVRGLSTTVLTETGTVTSGEFAGGHVVETFTAANLDLLGCLTPGGVTSLNFATVLTITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCT8</accession>
    <name>A0A1E7NCT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287799.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene343"/>
    <dbReference type="EnsemblBacteria" id="ARF82139">
        <property type="protein sequence ID" value="ARF82139"/>
        <property type="gene ID" value="B6264_27620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38464">
        <property type="protein sequence ID" value="OEV38464"/>
        <property type="gene ID" value="HS99_0021430"/>
    </dbReference>
    <dbReference type="OMA" id="WNEWLVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21544" checksum="7EE43B8EFAFEF279" modified="2017-01-18" version="1">MAVNGFGVTEFQLFLLRRMADYHPELVEEAVRRLGATRASMREANKRWQAMVRSPRFPRGAARYAAVLGPAEASRPRRIGDLACTARQWALPLWPELRFEVLLGPAEIGAPVLNEWLVRADGAPPPVLRTAADLAPWNCVVGDVGTAFPGAVPREGSAPTRFRLDFAAPGADGRVRCWTADFTWGLLQEVREAGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW0</accession>
    <name>A0A1E7NCW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3944"/>
    <dbReference type="EnsemblBacteria" id="OEV38522">
        <property type="protein sequence ID" value="OEV38522"/>
        <property type="gene ID" value="HS99_0020880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11533">
        <property type="entry name" value="NTP-PPase_Af0060_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044548">
        <property type="entry name" value="AF0060_NTP-PPase_MazG-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="12129" checksum="9F0E7E713BA3A422" modified="2017-01-18" version="1">MEARLTAGRTPEWAVVDDIHRHISAHRAGLGLSLLHLQVVKIQEEAGEVAEALLGVLGANPRKGVSPTVADLQGELCDVITAAMVALRDTTADPGTVLAEHLARWQPSRLDPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND15</accession>
    <name>A0A1E7ND15_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hopanoid biosynthesis associated radical SAM protein HpnH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene653"/>
    <dbReference type="EnsemblBacteria" id="ARF77607">
        <property type="protein sequence ID" value="ARF77607"/>
        <property type="gene ID" value="B6264_00535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38582">
        <property type="protein sequence ID" value="OEV38582"/>
        <property type="gene ID" value="HS99_0020120"/>
    </dbReference>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="38912" checksum="DBD18166693E78C1" modified="2017-01-18" version="1">MAMPLRQTVRVGTYLMQQKLLKRRDKFPLIVELEPLFACNLACEGCGKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVERRKYVFLCTNALLLRKKMDKFKPSPYFTFAVHIDGLRERHDESVAKEGTFDEAVAAIREAKRRGFRVTTNSTFFNTDTPQTVIDVLDYLNDELKVDEMMISPAYAYEKAPDQEHFLGVEQTRELFRKAFAGGNRKRWRLNHSPLFLDFLEGKADFECTPWGIPNYSLFGWQRPCYLMADGYVPTYRELVEKTDWSKYGRGKDPRCENCMAHCGYEPTAVLATMGSLQQSLRAITETVSSSRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND82</accession>
    <name>A0A1E7ND82_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287741.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene315"/>
    <dbReference type="EnsemblBacteria" id="ARF82165">
        <property type="protein sequence ID" value="ARF82165"/>
        <property type="gene ID" value="B6264_27760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38443">
        <property type="protein sequence ID" value="OEV38443"/>
        <property type="gene ID" value="HS99_0021295"/>
    </dbReference>
    <dbReference type="OMA" id="EPSVMNM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="92"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="565" mass="59217" checksum="981F976FFCF44F5D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND97</accession>
    <name>A0A1E7ND97_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552175.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000542.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1771"/>
    <dbReference type="EnsemblBacteria" id="ARF77684">
        <property type="protein sequence ID" value="ARF77684"/>
        <property type="gene ID" value="B6264_01005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38651">
        <property type="protein sequence ID" value="OEV38651"/>
        <property type="gene ID" value="HS99_0020590"/>
    </dbReference>
    <dbReference type="OMA" id="YSAGAHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="40212" checksum="B1C4B9698EEF3E6D" modified="2017-01-18" version="1">MELTGTPFFILTVVLVPVSITVALLFWGKVRGPQPVRTLSRIVMIMFCQVTAVLMVFVMVNNANLIYGNWDDLLGTGDHVRAVPSVPPADPAGNGQSGDAAKQPPKVLQKFGGVNDPAVPGDVQKTELKGQVSGVDGEVLVWLPPQYNDPAFKDKKFPVVELIPGYPGSSSTWYGTLKVSEQLKPLMQQGKVAPFILVSPRTLLLGSHQDAGCTDIPGKINADAWITRDVPQMVMDNFRADPSADRWAIAGYSAGAHCAAKLSLAHPNRYRAGIAMSGYNDPAVEPDSLVGKDAKLREASNPVNILKSAQQPPKVALLVSGAKGDGYEDGQAIAAVAKEPTKVQVEESTGPHTTDMWKRMVPSAFEWLTGIIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDB2</accession>
    <name>A0A1E7NDB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287828.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene356"/>
    <dbReference type="EnsemblBacteria" id="ARF82131">
        <property type="protein sequence ID" value="ARF82131"/>
        <property type="gene ID" value="B6264_27555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38473">
        <property type="protein sequence ID" value="OEV38473"/>
        <property type="gene ID" value="HS99_0021490"/>
    </dbReference>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="31900" checksum="8C2215527A5E1D49" modified="2017-01-18" version="1">MPALHPLLSAFAPIWALTAVGYLVARAGLIGPQAEMVLTRYVFHVAMPAALFLMIARTPLGHFANPSMLAFVAGAAVATGLGLLAGRVLFRRERGELAIGAMAAGYVNSANLGIPVTMQVVGDASFVGPVILFQILLVTPAVLAVLDSGAAGRRALLTLPLRNPVLLATALGALASATGLHLPAELHHSAELLGGAGVPTALVALGMSLHNRPPADGLSRRVEVGLTVAIKTLVQPLVTLLVAGPVLHLPAHQLLTVVLFSALPTAQNIYTYAREYGQGTDLARDTVLWSTLVSMVTLSVIAWTLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD0</accession>
    <name>A0A1E7NDD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552177.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000247.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1774"/>
    <dbReference type="EnsemblBacteria" id="ARF77687">
        <property type="protein sequence ID" value="ARF77687"/>
        <property type="gene ID" value="B6264_01020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38654">
        <property type="protein sequence ID" value="OEV38654"/>
        <property type="gene ID" value="HS99_0020605"/>
    </dbReference>
    <dbReference type="OMA" id="QEADDVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="16994" checksum="97E99A9BEC22A861" modified="2017-01-18" version="1">MRVTFTANGKPVEADDVWEGESLLYVLRERVGLPGSKNACEQGECGSCTVYLDGVPVCSCLVAAGQVQDREVRTVEGLAEETGELGLVQQAFVDAGAVQCGFCTPGLLVQTDALLEKDTQPSDNDIREALSGNLCRCTGYEKIMDAVRLASARKCAGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDW0</accession>
    <name>A0A1E7NDW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6535"/>
    <dbReference type="EnsemblBacteria" id="ARF81304">
        <property type="protein sequence ID" value="ARF81304"/>
        <property type="gene ID" value="B6264_22510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38896">
        <property type="protein sequence ID" value="OEV38896"/>
        <property type="gene ID" value="HS99_0019775"/>
    </dbReference>
    <dbReference type="OMA" id="WHQSKVS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="30803" checksum="5EC9F56B53C09F65" modified="2017-01-18" version="1">MLGAELRRIREGLNLRVDDVAARLGWHQSKVSRLENGRHGVKANEVGILLDVYEISDPETREALATLAREGKRRVWWQPYSDVISQRYASFISFEAEAVAIRNFESSLIPGLLQTADYARAVTRKLQPEGTTEEVNALVDVRLARQNAALRREEPLKLWAIVDEAALRRVVGNKAIMAKQLQQLIAASREPNVTLQVVPFDAGAHPGVLGSFVIMEFPVRNDLDVVYTEALTSSLYLERDDDVTAYDQAFDRLRAAALDVGPSRRLVTQIAKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE22</accession>
    <name>A0A1E7NE22_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555467.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6534"/>
    <dbReference type="EnsemblBacteria" id="ARF81303">
        <property type="protein sequence ID" value="ARF81303"/>
        <property type="gene ID" value="B6264_22505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38895">
        <property type="protein sequence ID" value="OEV38895"/>
        <property type="gene ID" value="HS99_0019770"/>
    </dbReference>
    <dbReference type="OMA" id="LSNARWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7685" checksum="5F32D4FFBB3B5877" modified="2017-01-18" version="1">MINPGRDSLKHATWRKSRFSGNQGNCVEVADGFTGIVPVRDSKDPNGPALAFPAEAWTAFVAAIKTGELPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE58</accession>
    <name>A0A1E7NE58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557366.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4361"/>
    <dbReference type="EnsemblBacteria" id="ARF83224">
        <property type="protein sequence ID" value="ARF83224"/>
        <property type="gene ID" value="B6264_30250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38996">
        <property type="protein sequence ID" value="OEV38996"/>
        <property type="gene ID" value="HS99_0017980"/>
    </dbReference>
    <dbReference type="OMA" id="IRCHIDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17085" checksum="1981EA15C326795E" modified="2017-01-18" version="1">MTTTTYGTGTVPGLTAQEPILPAPRPGLYLVPRLGGITAHLTADQDTVQTVRALALTVLVAHGVDLETAESAQLVLSELIGNAVRACGDHVPLVVEIYRSRGVDAVVTVHDPLAGAGPRRTDTTPDSDEAESGRGLLLLDILAPGWTVTPSPIGKAIRCRIPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE90</accession>
    <name>A0A1E7NE90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737776.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83251">
        <property type="protein sequence ID" value="ARF83251"/>
        <property type="gene ID" value="B6264_30390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39021">
        <property type="protein sequence ID" value="OEV39021"/>
        <property type="gene ID" value="HS99_0018120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18676" checksum="BBF6D88B50AE6EAA" modified="2017-01-18" version="1">MAARRHTVPGHLVGAGRVTLSRTGGGAGPDWGAYAVLYTTRPVDGGSEAVIGYCMPDDPLLDPAWGLHRQQPYGPAGTARHPLGDYAAASDPARGRSESPASYGQRMALFLLRIATATRLVHSPRIIDLPWAAWTLATEQHVHLAPDPDHPGRGWAGHHQVRVGRILTLQPKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ2</accession>
    <name>A0A1E7NEJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557494.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000345.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83288">
        <property type="protein sequence ID" value="ARF83288"/>
        <property type="gene ID" value="B6264_30615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39055">
        <property type="protein sequence ID" value="OEV39055"/>
        <property type="gene ID" value="HS99_0018330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16766" checksum="EBC5DFEE47545E5B" modified="2017-01-18" version="1">MSSSDLQLQDLLSAALEDTVATAHAEAARWLTAQLEQRGTEAMWEGTCRLLSALAVRPAYGLPPHEAADRLRLTARSAQPDVALVLSLRLALWERGEEGAAEVWHAAPVELRRQAIMHLVIAYCATVGYDGRRLSPAETVSLVRQAFPPAGRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL9</accession>
    <name>A0A1E7NEL9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557180.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4106"/>
    <dbReference type="EnsemblBacteria" id="ARF83343">
        <property type="protein sequence ID" value="ARF83343"/>
        <property type="gene ID" value="B6264_30970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39114">
        <property type="protein sequence ID" value="OEV39114"/>
        <property type="gene ID" value="HS99_0018695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="36683" checksum="903C2F56C3854CD8" modified="2017-01-18" version="1">MTDTTRPDPARAAAPERLELALYSSRPAPADRDLGRPILDSPLVRGSMWLRWTRHDGIRTLHHGADLARGWVEKDVDGLDGWVALVDGRIVRSARPGLAVPEPVVHAESWEAGATLHAALAQHPNHPEHAPDEDDDQEHGLLGGIRSRVRRKAAGMTLETIQQALHRARDDERAADRHADAGDEAAYATAAAVCAEWQRVRDHTAETRAERYDPDHDTALQHALRREHHRQDVAECAREATHQARQTTDAAHRRLAGTAAQPLYTALDRAGLHALTDDDHQAVRDLTRTLDPATLRQVMSWLERTRTAAFALRGTGQASPVRPVVRRRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEN6</accession>
    <name>A0A1E7NEN6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835455.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3485"/>
    <dbReference type="EnsemblBacteria" id="OEV39176">
        <property type="protein sequence ID" value="OEV39176"/>
        <property type="gene ID" value="HS99_0000125"/>
    </dbReference>
    <dbReference type="OMA" id="GYYVGYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199055" description="Beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="42"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="46288" checksum="FBB7A457EBD350A4" modified="2017-01-18" version="1">MTADPTAPRRRFRRPVLRAAVTIAAGAGLLATLAPAAVAQAADRSPASGCHGALHLTAADRADRTDSAEGRAGWAAADSALAGLTGPGYATSALGAVREDGRLLWRNASGVAALGGGRPADPDGRFRIGSATKTFVATTLLQLVGDRRLDLDDRLECLLPGVVPNSTAITVRQLLDHTSGVANYTQDPAFEPNDPDWLTDRRFQPYSLQDLVDIANRYPPAFPPGQDWAYSNTNFVLIGMIIEKLTGHSWQEEVTRRIIRPLHLTGTTMPGNSPFVPGPHAHGYLRTATGPVDVTLLDPSMAGSAGAGISTTADLTTFIAALLGGRLLPPAQLAEMQRTSRIGGGRNYGLGLQRVDTPCGTFWGHAGGIPGYSTLMLGSADGRRQFAASITVYDVRDGTAANAAWDKLTGIALCGPQAPALAPSAVPGLSAVPGPASDLARTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEP3</accession>
    <name>A0A1E7NEP3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000951.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3496"/>
    <dbReference type="EnsemblBacteria" id="OEV39186">
        <property type="protein sequence ID" value="OEV39186"/>
        <property type="gene ID" value="HS99_0000175"/>
    </dbReference>
    <dbReference type="OMA" id="GAGMCVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7636" checksum="D61EB110FDD531E7" modified="2017-01-18" version="1">MQVSVDRDRCCSSGMCVMNAPAVFDQDDRDSLVMLRQAVVQPEQFEDVRLAAELCPSGAITVTEDGAAGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NET3</accession>
    <name>A0A1E7NET3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285197.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3525"/>
    <dbReference type="EnsemblBacteria" id="OEV39209">
        <property type="protein sequence ID" value="OEV39209"/>
        <property type="gene ID" value="HS99_0000310"/>
    </dbReference>
    <dbReference type="OMA" id="EHRELCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11134" checksum="67284315B9460FFE" modified="2017-01-18" version="1">MADDRELFEDVTEALARAGFDTAPGASPLSIGPHPEGVVVGWSPGEEPDGPPSGLARAAVTGAAALVLRERGFLVTETGEGCLLVRCAEPVTVPPEAEAEAAPEQWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF05</accession>
    <name>A0A1E7NF05_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD</name>
        <name evidence="7" type="ORF">HS99_0000340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550154.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000464.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3531"/>
    <dbReference type="EnsemblBacteria" id="OEV39215">
        <property type="protein sequence ID" value="OEV39215"/>
        <property type="gene ID" value="HS99_0000340"/>
    </dbReference>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="52677" checksum="EDCC338B0480BACD" modified="2017-01-18" version="1">MAERMAFLTTPRTERERRDARERLGDRREVYRPGALLPVVGGQAARCMDCGLPFCHAACPLGNLVPEWNRLAADGDWRAAAARLLATNNFPEFTGRLCPAPCESACVLAIDGAAVTIKNVELAIADRALEEGWDGPLPPERRGAVRRVAVIGSGPAGLAAAQQLTRAGHATTVYERADRAGGLLRYGIPPFRLEKHRLDRRLDQLRSEGTEFRTGVWAGRDVTGEWLRAEYDAVVVAVGATAHREPAVPGRRLPGVHPAMEYLTWANRVDEGDLANSPLSAEGRRVVIVGGGDTAADCLGTALRQGAAAVTQFDINPRPPRRRAPGQPWPVHPKVYRVTTSHEEAGAVAGGPEPSAEDGRVFQAVTVGFEPGPDGQLAAVRFASCAEGGREARAGTERVLPAQLALLALGFSGPEPDQPLFAQLGLAVGPEGVLERDDGFGTATEGVFVAGDAGRGQSLIVWAIAEGRSAAAAVDRYLRGRTELPAPVGASARALTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF50</accession>
    <name>A0A1E7NF50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3586"/>
    <dbReference type="EnsemblBacteria" id="OEV39255">
        <property type="protein sequence ID" value="OEV39255"/>
        <property type="gene ID" value="HS99_0000605"/>
    </dbReference>
    <dbReference type="OMA" id="GRERWRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="40237" checksum="29EA2FE2B9EB44F6" modified="2017-01-18" version="1">MNTDAPQNEPVLHRINRRRLLLSAAGGVGALAVSAGAGWWARRDPARGPRLWSSSAPGGRIALPVESVGSLCVSGYDGRVSALDPRTGAVRWSKAVVAPGVADTPSGLPLAVGDGVVCVTAPNRVHVFDAASGEARWEVPVPDWRDVPWSQSPAVGGGGVFAPYGTALRSYDVADGSLRWSGPPNSSGRLVVAGGTLYTPGGPAGLRAFDTRSGELRWEQNSVRTVQVAGGPSVHQGAAYLADCDPDMGNPAVLALDAGTGRVRWRRTQPKVLSCPPSVADGTLCLFSGDRLTALDADTGETRWAVTTPIGLGRGESSMTAADGIAYVGTNDDRLYAFDLATGRLRWQDEPEHLGTGGEFTVVSLAAAGAAVYRGSRTGVHALGALPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL7</accession>
    <name>A0A1E7NFL7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a structural or regulatory role in gas vesicle synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
            <location evidence="2">Gas vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285889.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5091"/>
    <dbReference type="EnsemblBacteria" id="OEV39477">
        <property type="protein sequence ID" value="OEV39477"/>
        <property type="gene ID" value="HS99_0001925"/>
    </dbReference>
    <dbReference type="OMA" id="RYGLTMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031412">
        <property type="term" value="P:gas vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007805">
        <property type="entry name" value="Gas-vesicle_GvpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40137">
        <property type="entry name" value="PTHR40137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05121">
        <property type="entry name" value="GvpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="15286" checksum="CB673DCD8426CE9D" modified="2017-01-18" version="1">MTTDEPPRPDRRQEVAQAATRAFRVLPATTSETATGRGRPRHAPRRITTGPETVERDLMKLVLTLVELLRQLMERQALHRVEAGDLTEEQEENLGATLMALHERMNDLCARYGLTMQDLNLDLGPLGPLLPPDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS4</accession>
    <name>A0A1E7NFS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285838.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5064"/>
    <dbReference type="EnsemblBacteria" id="OEV39498">
        <property type="protein sequence ID" value="OEV39498"/>
        <property type="gene ID" value="HS99_0002055"/>
    </dbReference>
    <dbReference type="OMA" id="EWRTANT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199103" evidence="1">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="40"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="34784" checksum="AABFFA9B39F52F92" modified="2017-01-18" version="1">MSKRAAAALVAGAMVTVLTACGSGGGGGSADKGAGHKLVVGFSQVGAESGWRTANTKSIQESAKKAGIELKFSDAQQKQENQIKAIRSFIQQKVDVIAFSPVVESGWDTVLKEAKDAKIPVILTDRAVDSKDDSLYVSFLGSDFVEEGKKAGDWLVKEYQGKSDEVNIVELQGTTGSAPANDRKAGFGDVIKADAKFKVVASQTGDFTRAKGKEVMQAFLKAQPKIDVLYAHNDDMALGAIQAIEEAGKKPGTDIRIISVDGVKDAFTAMSQGKINVDVECNPLLGDQLMDLAKKVKAGEQVPKRIKTQEGVFTQDQAAAELPTRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW1</accession>
    <name>A0A1E7NFW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367049.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6760"/>
    <dbReference type="EnsemblBacteria" id="OEV39538">
        <property type="protein sequence ID" value="OEV39538"/>
        <property type="gene ID" value="HS99_0002305"/>
    </dbReference>
    <dbReference type="OMA" id="WTRAREC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="24257" checksum="B4B819C2B42AB305" modified="2017-01-18" version="1">MTPPRPGGPHPESGRAGRLRLRHRLEVALRGAELLDRKLAVLRERHRLLAAEEEAARRAWHTAVQEAETWLLRGLLLSGDRALAAVVANRADVVVEWTVSMGVRHPSRAVCTDAARATTEPPPANTALAHAETAYRTVVRTAAGYAAARTAAGLVQAEIDRTGRRVRALRRHWIPRLAEALAHLDQGLEQAEHEDAVRRRWAAGAPGRSPTAGAGSAGRADTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW6</accession>
    <name>A0A1E7NFW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737766.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2734"/>
    <dbReference type="EnsemblBacteria" id="OEV39601">
        <property type="protein sequence ID" value="OEV39601"/>
        <property type="gene ID" value="HS99_0002700"/>
    </dbReference>
    <dbReference type="OMA" id="FHPLFVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199109" evidence="1">
        <location>
            <begin position="30"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="534" mass="55684" checksum="A0A339D395D6838B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX3</accession>
    <name>A0A1E7NFX3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279188.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000512.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2745"/>
    <dbReference type="EnsemblBacteria" id="OEV39609">
        <property type="protein sequence ID" value="OEV39609"/>
        <property type="gene ID" value="HS99_0002755"/>
    </dbReference>
    <dbReference type="OMA" id="IFVGQWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9687" checksum="26FB7161B4BADE77" modified="2017-01-18" version="1">MIMEKLHKAGVKSEHAYMAGLASIGLSFVSWMVSVKAEAAGVERADRWGIFVGEWAPTFFCMGLALSQYERDDNPVYANDPRVTATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY6</accession>
    <name>A0A1E7NFY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6751"/>
    <dbReference type="EnsemblBacteria" id="OEV39545">
        <property type="protein sequence ID" value="OEV39545"/>
        <property type="gene ID" value="HS99_0002350"/>
    </dbReference>
    <dbReference type="OMA" id="EVELHHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="30104" checksum="78B4D24E72897441" modified="2017-01-18" version="1">MIGPGESRPVVVGVDVRDSVRPALDWAADEAERREAPLRLVHAVPPGHYGQRGTDGSKQRKAGQRLLDEAAASVSGRHPGLHIATVLEEGAPAQALYRESHNACLVVLGSRRLSRLEELLSANSVAVPVSAQAACPVVVVLEPGNSTEQPPHLVVGVDGSPASHAAVEHAFETAAARDTHLRALWVWQPSLLESTDEVNALQKCRRLLSEAVAEQAANHPSITVTRQVVRGHPVEELAKASENALAVVVGRRGRGGFTGMRLGSVPHGLLHRAHCPVVTVPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG85</accession>
    <name>A0A1E7NG85_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550418.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2834"/>
    <dbReference type="EnsemblBacteria" id="OEV39684">
        <property type="protein sequence ID" value="OEV39684"/>
        <property type="gene ID" value="HS99_0003200"/>
    </dbReference>
    <dbReference type="OMA" id="VRHYHKL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28595" checksum="FDEEB4E6C86EFD4B" modified="2017-01-18" version="1">MMSGVTIGQAAAFLGVSVKTVRHYHEHGLVAEPRRDASGYRRYGSDELLRLVQVRTLATAGVPLAEIGPLLDADAEHFAAALADVERRLAERIAELAARRETLHRLAEGDRALLPDRACATLDRMPALGFDPAYVTAQREALVLARVLVPDGFDGFLTQLEHQLDDPGFVELAQRGWEARDWDPDDPRIEELAAAMADRYLANPGLLGDPGSLEAWSRAATQYRLIDGHREEQAPVSARLTALTEARLRSAGVAGPRLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ5</accession>
    <name>A0A1E7NGJ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6744"/>
    <dbReference type="EnsemblBacteria" id="OEV39839">
        <property type="protein sequence ID" value="OEV39839"/>
        <property type="gene ID" value="HS99_0002380"/>
    </dbReference>
    <dbReference type="OMA" id="IMAWESH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16437" checksum="A97CDFB8023B8D8D" modified="2017-01-18" version="1">MVVGTDGSEPARRAVLFALREAQLRGVGVRAVCAYGGGRTEPSNRAMTGWRDAGSEPLPHLHDTVAREVTDFVEELRQQVGEPHVEVEVRCERGRPAKILLEESQDATMLVVGTRGAGLWGRLTLGSTSTEVVHHAHLPVVVVPPEPRTPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NHB0</accession>
    <name>A0A1E7NHB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6728"/>
    <dbReference type="EnsemblBacteria" id="OEV39843">
        <property type="protein sequence ID" value="OEV39843"/>
        <property type="gene ID" value="HS99_0002465"/>
    </dbReference>
    <dbReference type="OMA" id="FIKGHSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20103" checksum="FFBF86D851AEE43A" modified="2017-01-18" version="1">MTHAVVAVGRDADFREVAETLQRWRVSAVPVLTGDGRVVGVVSEADLLTARDRDGERADALTAGRMMSVPAVTAHPGSPLNEAARAMARGHLKRLPVVDEEDYLVGIVSRGDLLKVYLGDDRELADRVRFELVATLGPSAAVDTDIRSENGRITLTGSLPDMVSADVLERLVRSVPGVAGVELRLAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FAR5</accession>
    <name>Q9FAR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ACP synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tcsD</name>
        <name evidence="6" type="ORF">HS99_0013270</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <title>Analysis of the chlortetracycline polyketide synthase genes from Streptomyces aureofaciens NRRL3203.</title>
            <authorList>
                <person name="Nakano T."/>
                <person name="Ikeda M."/>
                <person name="Mizukami T."/>
                <person name="Katsumata R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">NRRL3203</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762</strain>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="AB039379">
        <property type="protein sequence ID" value="BAB12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q9FAR5"/>
    <dbReference type="STRING" id="1894.JOER01000001_gene5202"/>
    <dbReference type="EnsemblBacteria" id="OEV33522">
        <property type="protein sequence ID" value="OEV33522"/>
        <property type="gene ID" value="HS99_0013270"/>
    </dbReference>
    <dbReference type="OMA" id="MNNNFAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="11"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAB12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="45519" checksum="60F0F69C67720841" modified="2001-03-01" version="1">MVGVDDGRRRVVVTGIGVVAPGEVGTKAFWELLTAGRTATRTISTFDPSPFRSRVAAECDFDPQAAGLTQRQIRQWDRTAQFAVVAAREALDDSGVSGVNDPIRTGVMAGTACGMTISLDREFAVVSDEGRKRLVDDAHGVPYLYDYFVPSSMATELAWLVEAEGPVGVVSTGCTSGIDVIAHACDLIRDDAADVMLAGASDAAISPITVACFDAIKATTPRNDEPESASRPFDLTRNGFALGEGAAMFVLEEREHAIRRGAHIYAEVTGYAGRCNSYSMTGLRVDGNEMAEAIRVALDRSRMNPEDVGYVNAHGSATKQNDRHETAAFKKSLGDHAYRVPVSSIKSMIGHSLGAVCALEFAASALAIEHSVVPPTANLHVPDPECDLDYVPLVAREQRVRTVLSVASGFGGFQSAIVLAEPEWSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVA8</accession>
    <name>A0A1E7MVA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000462.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6964"/>
    <dbReference type="EnsemblBacteria" id="OEV32370">
        <property type="protein sequence ID" value="OEV32370"/>
        <property type="gene ID" value="HS99_0016870"/>
    </dbReference>
    <dbReference type="OMA" id="PQPGIRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="46462" checksum="D31E87D45E687019" modified="2017-01-18" version="1">MTQDHATPAGPFAAADALSGHPLFARLARLGQRLREADRAHPWVLDAAVVAVVFLMFCLPDLFPPHGEDGPHEHRLALVRPPLPATLALQAGLVLPLLWRRRRPTEAFAAIMAVFVLQWSLGIGLRADAALLVALYSLALHGRLRHLAWSCAVMVGAMGLVAVEVSGGGLPVGDALFFLVSAATAGVALGIAVRIRRAQLAGLRERAARLEIERDQRSRLATATERTRVAREMHDIIGHNLSVIVTLADGGAYAALASPERGREALQLIGETSRQALGELRRMLGVLRDQADRGAEFNPQPGIADLDGLCARIRAAGPQVVYTVGGDLDQLDRGVQLMAYRIVQEALTNTLKHAGPETRAHVTLTADATRVRVRVRDSGPPGGARPPVRPDGEGHGLAGMRERAAVYGGTVTAGPGPGAGWTVEAVLDLTPDPTGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVB9</accession>
    <name>A0A1E7MVB9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553849.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6970"/>
    <dbReference type="EnsemblBacteria" id="OEV32376">
        <property type="protein sequence ID" value="OEV32376"/>
        <property type="gene ID" value="HS99_0016900"/>
    </dbReference>
    <dbReference type="OMA" id="VVKVSVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="29728" checksum="CD10CFAC8637DDED" modified="2017-01-18" version="1">MIVVTGATGTVGSKVVVGLRERGRSVRALVRAGSEGPAEWDEAVERVAADFADPASLDAALAGADTVYLLVAVHPEMAQHEKNVVDAAVRTGRRPRIVLHAAAGIEYRPEGVRFIGAHIAGLDHLKASGLPWTVLGPNGFYQNFLGTAPTVRAGHLAVPGGDGAVSYVDARDVAAAAVEVLATEGHEGAVYTLTGPAALTHGELAAQLATVAGHPIAYTALTPEVALEGLLGMGWERWRAEGMVELYGLYAAGRASAVSSDVEKLTGRPPRTFAEFAAEHAEAFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI2</accession>
    <name>A0A1E7MVI2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32441">
        <property type="protein sequence ID" value="OEV32441"/>
        <property type="gene ID" value="HS99_0017315"/>
    </dbReference>
    <dbReference type="OMA" id="DGHFVIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010753">
        <property type="entry name" value="DUF1330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07045">
        <property type="entry name" value="DUF1330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1330" evidence="1">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="12176" checksum="328345ACAC7929A7" modified="2017-01-18" version="1">MSAFALAQVHSAEMCPDIVEYLERIDDTLDPFGGRFVVHGGTFENPEGSWGPLGLILIEFPDYERARAWYDSPAYREILPLRTRHMVADVIIAEGVPAGYRGADALKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM3</accession>
    <name>A0A1E7MVM3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0017530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290119.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000691.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1229"/>
    <dbReference type="EnsemblBacteria" id="OEV32480">
        <property type="protein sequence ID" value="OEV32480"/>
        <property type="gene ID" value="HS99_0017530"/>
    </dbReference>
    <dbReference type="OMA" id="VDEEKCC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7264" checksum="B6C5FB70284C415F" modified="2017-01-18" version="1">MLVQIDQEKCCGAGHCVLAAPDVFDQRDEDGIVVLLDARPPAELHQAVQDAAAVCPAAAIQLDQAPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR2</accession>
    <name>A0A1E7MVR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7009"/>
    <dbReference type="EnsemblBacteria" id="OEV32522">
        <property type="protein sequence ID" value="OEV32522"/>
        <property type="gene ID" value="HS99_0017100"/>
    </dbReference>
    <dbReference type="OMA" id="RYNTERP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="37"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="43222" checksum="6CB3833D4CA59957" modified="2017-01-18" version="1">MSPNSSTAPDPGPAPVRAMLVLGTRPEAIKLAPVARAMAASPHFEPLVVTTGQHREMLQQMLELLNVQAKFELDVMRERQELSKLTARLVDRLGEVVRAERPDLVIVQGDTTSALTGALAAFYEHVPVAHVEAGLRTGVADNPFPEELNRRLIGRIARRHFAPTPRAAGHLIAEGVPAGEVFVTGNTVVDNLLWVLEQGVGRDQFESSGALRRLLVTLHRRENQGDTMRAMGKALRRLADRGDAEIVLPLHRSPAVREVLLPELSGHPGIRIVEPLGYADFSATLAGCDLVLTDSGGIQEEAPTLGKPALVLRTTTERPEAVEAGAARLVGTDPDVIMDATVRLLDDEAAYRRMAKAGNPFGDGHATARIVAQLARDFGVEAAAASTAVPSVTPRPGGAGSYSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT2</accession>
    <name>A0A1E7MVT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000095">
        <property type="protein sequence ID" value="OEV32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386333.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene105"/>
    <dbReference type="EnsemblBacteria" id="ARF80101">
        <property type="protein sequence ID" value="ARF80101"/>
        <property type="gene ID" value="B6264_15300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32540">
        <property type="protein sequence ID" value="OEV32540"/>
        <property type="gene ID" value="HS99_0040220"/>
    </dbReference>
    <dbReference type="OMA" id="AFLDIDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17896" checksum="11896549F36A5A27" modified="2017-01-18" version="1">MPSDLSPSDLSPSDLSLAVLTPDNIDAALALRVRPDQEGLVAPVAKSLAEAYVHGETAWPRLVLDGGRPVGFVMAFFDVRFDPEHPDDRPRSGLWRLLVDAERQRGGYGRFAVEQVCAEIRRRGGSRATVTYHPGPDGPAGFYARLGFRPTGELSGGQEVAELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV4</accession>
    <name>A0A1E7MVV4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551635.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000807.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8135"/>
    <dbReference type="EnsemblBacteria" id="ARF79762">
        <property type="protein sequence ID" value="ARF79762"/>
        <property type="gene ID" value="B6264_13375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32562">
        <property type="protein sequence ID" value="OEV32562"/>
        <property type="gene ID" value="HS99_0040065"/>
    </dbReference>
    <dbReference type="OMA" id="WAWLESG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="37461" checksum="3BF3E3DA9AB8FD9B" modified="2017-01-18" version="1">MKILLLGGSSFLGRAYAVEALARGHQVTTFNRGLRSPDLPGVEAVRGDRDSAEDLARLVGGRRWDAVVDTSAQQPAQVALSVRLLRERADHYTFVSSVHACADWATQVITEDSPLLPCPADTPPGQPFGRELKAGCERAALTGIGAERTLVLSSGLLVGPYEVGGRLPWWLERMARGGRVLAPGDPGRTVQVIDVRDFAAFGLDLLTAGTAGRFLTTAPPGQLTFGQWLETCREVAGAPGTELVRIDDGPLLAEGPDRVEPWTELPFWAPDLPDWAYIWQVDSSRARAAGLRCRPFAETARDTWDWLRTRGPAEDTDAEGRKAAPGSLFRQGIEPAKEQRLLAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA9</accession>
    <name>A0A1E7MWA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5019"/>
    <dbReference type="EnsemblBacteria" id="ARF78233">
        <property type="protein sequence ID" value="ARF78233"/>
        <property type="gene ID" value="B6264_04255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32727">
        <property type="protein sequence ID" value="OEV32727"/>
        <property type="gene ID" value="HS99_0015830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="35384" checksum="9A6F162CAC7543D7" modified="2017-01-18" version="1">MLVGAAFGAVEAITVDLAVAQPIRVELFGDGGYSLTEAADSAKTGEIMGAAGGGLGAGARVVTTAAETTENASVALAGLAKVANAADTVPGRMITGAGLTYGYDTAFKTGPVMPLDLILGAVGSAAAPGGGSSRRPGRTPESPEYLPRTGGSDYIDPPQSESTQRNYEKIRQTTGDTERIAANTGYDLGVLNRIKAHIFENVHTGVSVPPDGRPATGRFAPMDHIADMWFKAEAGTLTPAESTKFFRWACHEGIESILMAPPHNLPYRQGYWEDGVHWPEPGNWGAHEVSPHETREDAFFAWDRLGLTRPDFPIAGDLSNLDEIAALILAQRNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWH2</accession>
    <name>A0A1E7MWH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0014985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3798"/>
    <dbReference type="EnsemblBacteria" id="OEV32780">
        <property type="protein sequence ID" value="OEV32780"/>
        <property type="gene ID" value="HS99_0014985"/>
    </dbReference>
    <dbReference type="OMA" id="DPEHHAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="29745" checksum="A53F10D519001981" modified="2017-01-18" version="1">MLGSISEAEDALQDAWLRYDRTDTGAVGNLGGWLTTVVSRVCLNQLRDRAARREEPLQPTGPDGAGGPERIPDPLLRREGVVDPEQEVMLADSVGLALMVVMESLSPAERVAFVLHDLFAVPFEEIAPLIEKTAAATRQLASRARRKVQGQAPAPDPDLGRQRRAVDAFFAAARNGDLDALLAVLDPDVVLRSDGGVGQARHTVVLNGAATVAGQAVLWGKLSPFARPALVNGTAGAVVIGDNGRALSIMAFTVVDGAIAAIDVIVDQERLASFDLSAFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWN7</accession>
    <name>A0A1E7MWN7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4350 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000083">
        <property type="protein sequence ID" value="OEV32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829546.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000929.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4118"/>
    <dbReference type="EnsemblBacteria" id="ARF82851">
        <property type="protein sequence ID" value="ARF82851"/>
        <property type="gene ID" value="B6264_15505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32841">
        <property type="protein sequence ID" value="OEV32841"/>
        <property type="gene ID" value="HS99_0039890"/>
    </dbReference>
    <dbReference type="OMA" id="HLVWYLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025646">
        <property type="entry name" value="DUF4350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14258">
        <property type="entry name" value="DUF4350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4350" evidence="1">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="39480" checksum="D192DF8323F1C8B2" modified="2017-01-18" version="1">MARRARWYLVFLAVLLVAAVGIAVLNRGHRYPPIDPRSYDSDGAHAVVALLEHQGVKVELGTDPAAAANGADTLVLPEPDLLSPAQLRAVAAARHQRLVLIAPGPAALGVLAPGIRAADEAGDAPFAPVRGTQPGCSLPEALRAGSASTGGMLYTSGSRGDGCYQRGHAYPLVRTPSGGGDVIVLGSGRFLRNDELAGDGNASLALGLLGSQPRLTWHLPDYTAPVAEGTPHKSFGDYIPKGWHWALYQLAVAAVLAALWRARRLGPVVSENLPVVVRAAETTEGRARLYRRAKAHGRAAEALRRAAAHRLAPALGVPLQAGAPEPEALCAAVAGRLPERPAADVRALLYGPPPTDDAALLRLADDLDALERQVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM1</accession>
    <name>A0A1E7MXM1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Manganese transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0014100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5700"/>
    <dbReference type="EnsemblBacteria" id="OEV33154">
        <property type="protein sequence ID" value="OEV33154"/>
        <property type="gene ID" value="HS99_0014100"/>
    </dbReference>
    <dbReference type="OMA" id="MIFYQQS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="551" mass="58193" checksum="36A3FFEBB29CB729" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU2</accession>
    <name>A0A1E7MXU2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0039065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene537"/>
    <dbReference type="EnsemblBacteria" id="OEV33252">
        <property type="protein sequence ID" value="OEV33252"/>
        <property type="gene ID" value="HS99_0039065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15737" checksum="112081E3BA264265" modified="2017-01-18" version="1">MRRTRTVPTAYYTARVRYRGRRLFLLLVLVTQTFQPTSLLVGLYREFYQLDMLNSVWTLILCNAAFNLAFAVWILTAYISSVPVEPEEAAMLDGLGWLGALRRVVLPPALPGVVTAVIFTFISAWNESRSCRWRCCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX1</accession>
    <name>A0A1E7MXX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366561.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78585">
        <property type="protein sequence ID" value="ARF78585"/>
        <property type="gene ID" value="B6264_06375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33287">
        <property type="protein sequence ID" value="OEV33287"/>
        <property type="gene ID" value="HS99_0038880"/>
    </dbReference>
    <dbReference type="OMA" id="QCFPAVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20579" checksum="CC760B1642FD0DCA" modified="2017-01-18" version="1">MDFASSNGPARATTSAKIVIAGGFGVGKTTLVGAVSEINPLRTEAVMTSASAGIDDLSHVSGKTTTTVAMDFGRITLDEDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPALDYFENSGLPFVVALNGFDGHQPHTAEEVREALQLGAETPVITLDARRRDSAKSALITLVEHALLARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY05</accession>
    <name>A0A1E7MY05_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557586.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80417">
        <property type="protein sequence ID" value="ARF80417"/>
        <property type="gene ID" value="B6264_17225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33316">
        <property type="protein sequence ID" value="OEV33316"/>
        <property type="gene ID" value="HS99_0011995"/>
    </dbReference>
    <dbReference type="OMA" id="VKFGQPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="24766" checksum="604D561595C5297A" modified="2017-01-18" version="1">MRSYTTKLTVAALAAATALSLAACGPDNSDPAGTGGATGAAPAQTGAATGGAAGGSTAAPSGAATGGAATGGAGSGGTATGGAATGGAGTAGTSGTSGGGAGGGAGGGKLPQAGTSVKFGQPASIDFADKTSNAAAKLQWTVTGIQPGSIKDFQDAKANTAGLDGRALFYVSWTMTNLSDTKLTFSDPAAKLKVYDASGNIGMGADPVGSTPVAKCNTPSWAGATKGVAFKGCSIVSFQAGVTPVMVGFGDASDITKVQAAWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY87</accession>
    <name>A0A1E7MY87_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553445.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000872.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3994"/>
    <dbReference type="EnsemblBacteria" id="ARF80498">
        <property type="protein sequence ID" value="ARF80498"/>
        <property type="gene ID" value="B6264_17690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33396">
        <property type="protein sequence ID" value="OEV33396"/>
        <property type="gene ID" value="HS99_0012465"/>
    </dbReference>
    <dbReference type="OMA" id="FGVYEDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="47578" checksum="D5C7419C76AC0729" modified="2017-01-18" version="1">MDDTTHRLAAPIPYDHAAEARWVPEPDKRPGRTAFQRDRARVLHSAALRRLAGTTQVVAPMRSDFPRTRLTHSLECAQVGRELGAALGCDPDLVETGCLAHDIGHPPFGHTGEEALDQAAEACGGFEGNAQSLRILTRLEPKRFAPQDDQPAARLAPWPGRSVGLNLTRAALDAATKYPWTKGAHPVDPASPKYGVYADDLPVFRWLRAGSPAGRKCFEATVMDWSDDVAYSTHDVEDGLQAGHIDPAALRAPGERAELFKVAERYAPDAEPEELAAALDRLLAQDWWPQAYDGTARARAGLKDLTSQLIGRFCLAAEQATRARYGPGRLTRYAAELVVPRGVRLECAVLKAVAVRFVMMRDEQAQLRARQRIVIAELAYVLTQRAPDGLDPVFAAMYHEAEDDRAALRTVVDQIATLTDASALALHAKLVGAAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY91</accession>
    <name>A0A1E7MY91_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="3" type="ORF">HS99_0012565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287575.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3977"/>
    <dbReference type="EnsemblBacteria" id="ARF80512">
        <property type="protein sequence ID" value="ARF80512"/>
        <property type="gene ID" value="B6264_17790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33408">
        <property type="protein sequence ID" value="OEV33408"/>
        <property type="gene ID" value="HS99_0012565"/>
    </dbReference>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8808" checksum="63B0D27C56E71296" modified="2017-01-18" version="1">MATQNEVQEGLAEIVNEIAGIPVEDVQLDKSFTDDLDVDSLSMVEVVVAAEERFDVKIPDDEVKNLKTVGDAVNYILTNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU8</accession>
    <name>A0A1E7MYU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549926.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5188"/>
    <dbReference type="EnsemblBacteria" id="ARF82911">
        <property type="protein sequence ID" value="ARF82911"/>
        <property type="gene ID" value="B6264_18420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33608">
        <property type="protein sequence ID" value="OEV33608"/>
        <property type="gene ID" value="HS99_0013200"/>
    </dbReference>
    <dbReference type="OMA" id="PWHLAAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="22644" checksum="CF87A33E371F248F" modified="2017-01-18" version="1">MDAVRVSALRERLAGTGWLEAVGGFAGSLRRSVERRGAGELLLVGTEAYEPWHLAAHLEDEAAWSAVPRLAPTLLRHRPPATAPTHLAHDLRRLTEAGRGATVLVVAPAAVGAPLLERVQDARRHGATVLALDGAGPVAPSTDGDLAGPTDPADLAGLADLAGLAHERLTVGTAAEEPFDLAQHLVSAAAGQPVGRRSALGRLAELAGRLASAPSLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ22</accession>
    <name>A0A1E7MZ22_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737974.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4948"/>
    <dbReference type="EnsemblBacteria" id="ARF80015">
        <property type="protein sequence ID" value="ARF80015"/>
        <property type="gene ID" value="B6264_14835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33678">
        <property type="protein sequence ID" value="OEV33678"/>
        <property type="gene ID" value="HS99_0038505"/>
    </dbReference>
    <dbReference type="OMA" id="MGNQFGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32725" checksum="6924B16215BECA3C" modified="2017-01-18" version="1">MDFLTRLPVLGPLVARVQRSRPYRVYEYFTAARGNRLAGAVTFFGFLALFPLLTVGLAVAVATLNGSQVDDLQHRISDQLPGLSDALNLPSLVANAGALGVVSGALLLISGLGWVDTMRTSIRDLWQLPEEKGNAVLRKAWDVVVLAGLGLVSLFSLAASAAGSTLAGRIADAIGLGSGYLLTGVGVLIAIACDMLLFAYLLAPFPGITGQRRRDLVHGALIGAVGFELLKLLLASYLGSVAGRSLYGAFATPVALLLWINFVSRLLMYCVAWTATADPDAARERTRAHGRALLAAADRSEAAAGTPAGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZE2</accession>
    <name>A0A1E7MZE2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0037610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557988.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000580.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4517"/>
    <dbReference type="EnsemblBacteria" id="ARF80375">
        <property type="protein sequence ID" value="ARF80375"/>
        <property type="gene ID" value="B6264_16980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33797">
        <property type="protein sequence ID" value="OEV33797"/>
        <property type="gene ID" value="HS99_0037610"/>
    </dbReference>
    <dbReference type="OMA" id="AEWQMLL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="719" mass="78998" checksum="1DAC3613C4655642" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ0</accession>
    <name>A0A1E7MZJ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551282.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000751.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6357"/>
    <dbReference type="EnsemblBacteria" id="ARF78767">
        <property type="protein sequence ID" value="ARF78767"/>
        <property type="gene ID" value="B6264_07410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33858">
        <property type="protein sequence ID" value="OEV33858"/>
        <property type="gene ID" value="HS99_0037235"/>
    </dbReference>
    <dbReference type="OMA" id="RTPERDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17955" checksum="226B87F91FF508E0" modified="2017-01-18" version="1">MDYLIRHALPQDLEEAGRITVDAFVGDGFTDPAGSYVDLLRDAGRRSREAELLVAVDAADERVLGCVTFAVGGTEWADIATPREGEIRMLATAAASRGRGVGEALVRASVTRSRELGLAGMAFSTRPEMTTAHRVYERVGFRRTPERDWAPFPGMDLMVYTMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ8</accession>
    <name>A0A1E7MZJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282205.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6363"/>
    <dbReference type="EnsemblBacteria" id="ARF78762">
        <property type="protein sequence ID" value="ARF78762"/>
        <property type="gene ID" value="B6264_07380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33862">
        <property type="protein sequence ID" value="OEV33862"/>
        <property type="gene ID" value="HS99_0037265"/>
    </dbReference>
    <dbReference type="OMA" id="FIGMGWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="45273" checksum="4E2FBEAA21C268B5" modified="2017-01-18" version="1">MKRQLIAAVGVAAMVVGLAACGSDGKKDGDSKASSTSADRYKGKTLKVWTMTGSAPKGWTDSVKSEFETTYPGSKVDFQTQEWTDIGPKITAALSEGSVDVLELGNTQTSGYAATGGLLDLTKDKSALGGDGWAANQNEAAMLDGKQYAAPWWVSNRVVAYNKDLWKAAGLTDAPKTLDEFYTDLDKLKATPGVADPIYLPGQEWYTYFGLLTGEGGKIAKKDGDKWVGGLESPEAQRAFETYKKLQSYSATGPKDKDEATPQQKDVFAKGNVGAMIALGWELPAEKDMPKDKIGFFPLPGKTADKPSGVFIGGSNLAVAAQSKNTDMAKDFLKIALDDKNEGLVAAAGNIPNKPALNSQLTGDFAKAAQAATAVGGITPNTPNWASVENKPNPIKDFLTAALQGGDYAATAKKYDDEIAKRLNEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZZ2</accession>
    <name>A0A1E7MZZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551758.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000504.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77863">
        <property type="protein sequence ID" value="ARF77863"/>
        <property type="gene ID" value="B6264_02025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34006">
        <property type="protein sequence ID" value="OEV34006"/>
        <property type="gene ID" value="HS99_0011180"/>
    </dbReference>
    <dbReference type="OMA" id="QTLAWHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="29158" checksum="614CB62B06048C42" modified="2017-01-18" version="1">MSWQYCGNQIKLWRARAGVSREDLAAEARYSYESLRSMEAGRRKPSPHLLQVADEMCDAKGILVAGVQFLKPEKYPHFAEDYMRYEAEAVVIHWYETLLIPGLLQTEETARTLLHANWPPLDDDTIEERVTARLERQEVLKTQTKSFNFLIGEAALRNPLASEVVHKCQLLHLLAVGSARHIVIQVVPGSGAHTGLNGPFILLDSDEHQRLAYEEGQAMGLLHSDPGKVSLLSQRHAMILQRALSPEASAEFIGKLAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T4</accession>
    <name>A0A1E7N0T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0036540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290914.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1897"/>
    <dbReference type="EnsemblBacteria" id="OEV34292">
        <property type="protein sequence ID" value="OEV34292"/>
        <property type="gene ID" value="HS99_0036540"/>
    </dbReference>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="22445" checksum="9C1574BD23326576" modified="2017-01-18" version="1">MTKGPGAPAAARPGRPAAALPSAPGIWNIANVLTMVRLLLVPVFVALLFAGGGHDPKWRSVAWASFAIAMITDLFDGELARRKGLVTDFGKIADPIADKAIMGAALIGLSVLGDLPWWVTAVILARELGITLMRFWVIRFGVIPASRGGKLKTLTQGIAVGMYVLDLHGWLATGRAVLMGLAVLLTVGTALDYVGQALRLRREGTAAERADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V2</accession>
    <name>A0A1E7N0V2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285306.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7642"/>
    <dbReference type="EnsemblBacteria" id="ARF78485">
        <property type="protein sequence ID" value="ARF78485"/>
        <property type="gene ID" value="B6264_05760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34305">
        <property type="protein sequence ID" value="OEV34305"/>
        <property type="gene ID" value="HS99_0036620"/>
    </dbReference>
    <dbReference type="OMA" id="QVWPWQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="477" mass="50966" checksum="7A0E6B3D7A1FF7DF" modified="2017-01-18" version="1">MRTRLLGILIALMLCVLAALGLPLAAAFAAAEQSRVVVDRLDDAARFAQDLPTSGAAALDSALKADPEPAPGDLSRRHAIEAEVQRYFDLYGVRLGIFQRDGAPIAVAPRDWRVPAVGWGAQAFQEALDGRRSHNPPQVWPWTEDRTITVAAPVVRDGDVVAVVLSESPTGALRARVLHKWLVLAGGEAAAMAVAVLLAVRLTEWVLRPVRTLDRATHDIATGRMAARVAPGGGPPELQRLARSFNEMADHVVHAMDQQKAFVADASHQLRNPLSALLLRVEVLGLELPEGHEEELGGVREEGSRLARVLDDLLGLATAEHARPEPEQTDLAQLTLARVDGWRPVAERRGIVLRWDGPALAIGMADPIGFGSALDAVLDNALKFSPSGSEVRLRVAVRRDEVAVTVSDAGPGLTEDELSRAGDRFWRSPRHQNVDGSGLGLSIARTLLAAGGGTLGFAPVKPTGLAVTLAVPRPERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W9</accession>
    <name>A0A1E7N0W9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386958.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000588.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6419"/>
    <dbReference type="EnsemblBacteria" id="ARF78715">
        <property type="protein sequence ID" value="ARF78715"/>
        <property type="gene ID" value="B6264_07100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34337">
        <property type="protein sequence ID" value="OEV34337"/>
        <property type="gene ID" value="HS99_0036435"/>
    </dbReference>
    <dbReference type="OMA" id="YRYFPGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27349" checksum="3DAC040167D07277" modified="2017-01-18" version="1">MEARPTTATDPTTATDPAPAQRPRRSGYRRLPVEQRREQLIAVALELFASRPPEEVGLDDVAEAAGASRPLVYRYFAGGKQQLYEAALRTAADELTSRFAVPLTGTPSEQLAAVLDGYFAFVAEHDAGYSALLRGGSVVETARTSAIVDDVRRAALRRTLRHLGVREAGPRLTLLVRSWIAVVEGASLSWLDEGRTLPVDGLRDWLVDQFTAMAAATALHDPQTAEVLAALLALEGPRADRAERLRAVLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N156</accession>
    <name>A0A1E7N156_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79248">
        <property type="protein sequence ID" value="ARF79248"/>
        <property type="gene ID" value="B6264_10265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34430">
        <property type="protein sequence ID" value="OEV34430"/>
        <property type="gene ID" value="HS99_0036085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8301" checksum="91CE7A452B45F6F6" modified="2017-01-18" version="1">MSWGFSMLLSCRKLACTAAAALAVACGVLAGSAHAATDSAPAVSPGTASVQQFTNHLTTQLHESQLLMLGGKATPADWRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N184</accession>
    <name>A0A1E7N184_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366605.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1054"/>
    <dbReference type="EnsemblBacteria" id="OEV34459">
        <property type="protein sequence ID" value="OEV34459"/>
        <property type="gene ID" value="HS99_0035750"/>
    </dbReference>
    <dbReference type="OMA" id="YPMRQYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="16995" checksum="A882953CB135C875" modified="2017-01-18" version="1">MAARPRFTSRATVLVLVLCSLVAILAYPTRQFISQRAEISAQRAKADHVRQQVEQLRRDKARWQDPEYVKAQARARLHYAVPGETPYIAADPSGAAARPSASATATGPSADAAGRPNAAKPWYAGIWDSVDAADTAALAPATPRPLPPSPVGDPTPHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F6</accession>
    <name>A0A1E7N1F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279036.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7078"/>
    <dbReference type="EnsemblBacteria" id="OEV34505">
        <property type="protein sequence ID" value="OEV34505"/>
        <property type="gene ID" value="HS99_0035495"/>
    </dbReference>
    <dbReference type="OMA" id="NGPWQIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198645" evidence="1">
        <location>
            <begin position="26"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="43971" checksum="744FB97585992833" modified="2017-01-18" version="1">MTSPARSSARRIAALLTGILLLVPAATGCGHNAGSGAAGGEVTAITALDYYTDESEHTQWGDLLTACGRTVGVRVEQTSVPGASLIPKVLQQASSRTLPDLLMLDNPDLQQIARTGALTPLDGYGIDADGFAQGIVSAGTYQGRVYGLAPNVSTVALIYNKDMLAEAGVAVPRTWDELKAAAAALTRPGRYGMAVDANATFEGTWQFLPFLWSNGGDERQLDTPQAAQALQLWVDLVKSGSMSKSVLNWTQADVHDQFVAGRTAMMINGPWRIPALEKDANLHWGVAPVPVPRLGQSPVTPLGGEVWAVPQNPSKARQEKAARVLSCLNSPSNMLTLAQEHHTVPSRTSVAAQHAEENPSTAAFARSVAAARARTSELGTEWPKAATGIYTAIQSALTGEQTPEEALSHAQQTATGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L1</accession>
    <name>A0A1E7N1L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290377.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5564"/>
    <dbReference type="EnsemblBacteria" id="ARF79353">
        <property type="protein sequence ID" value="ARF79353"/>
        <property type="gene ID" value="B6264_10850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34561">
        <property type="protein sequence ID" value="OEV34561"/>
        <property type="gene ID" value="HS99_0035320"/>
    </dbReference>
    <dbReference type="OMA" id="TPWHPHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PTHR13903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="34327" checksum="CE2C61A2FAEFD01B" modified="2017-01-18" version="1">MPAVTVDNPLTLPRVTTPDQAVANARPVLTVATAPEGYEGEGFPVRRAFAKINQKYLDPFIMMDQMGEVDYAAGEPKGTPWHPHRGFETVTYIIDGTFIHRDSHGGGGTITDGDTQWMTAGSGLLHIETPPESLVRSGGLFHGLQLWVNLPASDKMIAPKYQDIRGGSVKLLSSEDGGALLRVIAGELDGHQGPGTTFTPITMIHASISPGAQITLPWRADFNALAYGLAGNGSAGTEHRPFHRGQAVVFGDGDSITLRADEKQDSRDNNFEVVLLGGLPIREPVAHYGPFVMNSHRELQQAMEDFQAGRLGTIPADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N267</accession>
    <name>A0A1E7N267_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555794.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4580"/>
    <dbReference type="EnsemblBacteria" id="ARF81861">
        <property type="protein sequence ID" value="ARF81861"/>
        <property type="gene ID" value="B6264_25880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34777">
        <property type="protein sequence ID" value="OEV34777"/>
        <property type="gene ID" value="HS99_0009870"/>
    </dbReference>
    <dbReference type="OMA" id="DNANMAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="90"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="347"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="439"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="519" mass="54033" checksum="B13B1E1CF7D6F492" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J4</accession>
    <name>A0A1E7N2J4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">HS99_0034990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288601.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000639.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5875"/>
    <dbReference type="EnsemblBacteria" id="ARF77539">
        <property type="protein sequence ID" value="ARF77539"/>
        <property type="gene ID" value="B6264_00100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34919">
        <property type="protein sequence ID" value="OEV34919"/>
        <property type="gene ID" value="HS99_0034990"/>
    </dbReference>
    <dbReference type="OMA" id="CSSWQDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="15488" checksum="D55AFB8A00F459A9" modified="2017-01-18" version="1">MFKGFRSFLLRGNVVDLAVGIVIGAAFTAVVTGFVSAFLTPLVGVATGAVGDFTQKTFEVGGTKFPYGLFVNAVIGFVLVSAVIYFAVVVPVGKLQDRFEKSKPAPAAKVDCPECLSSIPAAATRCSFCTTEVAARPALPAQAQALQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P0</accession>
    <name>A0A1E7N2P0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389147.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81915">
        <property type="protein sequence ID" value="ARF81915"/>
        <property type="gene ID" value="B6264_26215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34723">
        <property type="protein sequence ID" value="OEV34723"/>
        <property type="gene ID" value="HS99_0009560"/>
    </dbReference>
    <dbReference type="OMA" id="FLYGHVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23214" checksum="5820D6017EFD8178" modified="2017-01-18" version="1">MAKHQAARRGRGERVGLSRQQILDAALGLVDRDGLKGLTMRSLGQELGVEAMTLYHYVPNKDALLDGLVEQVFTAATPAMDGSADWRTALQAYATALREGLLRHPAVLPLATSRPAVTPATLDDLEALLRLLTAGGFPLGRALHALNSLAVFVIGHATAEAQIVVGAEEAGGADWLAALEAERYPLLIRAAIEGVGADDAERFAFALDALLLGFDALRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N368</accession>
    <name>A0A1E7N368_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737922.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene387"/>
    <dbReference type="EnsemblBacteria" id="OEV35127">
        <property type="protein sequence ID" value="OEV35127"/>
        <property type="gene ID" value="HS99_0034185"/>
    </dbReference>
    <dbReference type="OMA" id="GDDETRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="29397" checksum="99C7691D4D63A767" modified="2017-01-18" version="1">MTAQAAHADLAAHADTSGHADTSAQGAAPAQGDPEPVPAADLARAHSAVQDPTVLDKVGHFFARKGVPPTRQLTIGAAEEAKAAQDEAPRLAGDTVPVYTLDAGFVAGTPGAPVAKVEFTASKVVAADGQTASVWTVRQGDAWRVVNIASGGDESDYAAKAADGGGTAFREPQVNAWYVLRDGRVLPLDDEARRSVGAGGVSLAAYQKLVHQRYGDKLPGSTYDREGRGGGYRLDAAAEAGPGAAAQAAPQAAADHDSAIPAVTAAAALGATALAAAGVGAGAVLRRKRAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N370</accession>
    <name>A0A1E7N370_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554010.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000301.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4423"/>
    <dbReference type="EnsemblBacteria" id="ARF78468">
        <property type="protein sequence ID" value="ARF78468"/>
        <property type="gene ID" value="B6264_05640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35130">
        <property type="protein sequence ID" value="OEV35130"/>
        <property type="gene ID" value="HS99_0033615"/>
    </dbReference>
    <dbReference type="OMA" id="GHNMSEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="14662" checksum="965CC97AD63B9AAE" modified="2017-01-18" version="1">MSSAPDRDLDWLLENLLAATPGTRHALVLSADGLKLCHTAGLSADQADQLSAIASGLQSLAHGASIEFGDGSGGVRQSMTEFHGGILCIVAAGEGAHLAVVTDDDADVGVVGHNMHGLIEQIGIHLSAPARGSDSGEAAAQESAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I6</accession>
    <name>A0A1E7N3I6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5280"/>
    <dbReference type="EnsemblBacteria" id="OEV35269">
        <property type="protein sequence ID" value="OEV35269"/>
        <property type="gene ID" value="HS99_0032935"/>
    </dbReference>
    <dbReference type="OMA" id="FTAGICD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198729" evidence="2">
        <location>
            <begin position="39"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="22420" checksum="DA0B8C5770B594AD" modified="2017-01-18" version="1">MDLETMPRRGRRVVALAVAALAAVVTLAGCNGGGKGSGDSAAGTASASASSSAPAGTSSPAPTASGSPSGGAATASPSGQPPTGWSPTPAEPAPGRPSAAATPPANGIAPGEPNPAGTGTANPNVRPPVSYRLDGSNKLTVYFFGGVCTTYAVKADESQQGQVGVTVVPGPPTVQPGHVCTAMAKRQAVSVDLRSPLAGRTVVDRTSGQEVPLEGDPHAGLDPVTPDGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4H8</accession>
    <name>A0A1E7N4H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278657.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2400"/>
    <dbReference type="EnsemblBacteria" id="OEV35373">
        <property type="protein sequence ID" value="OEV35373"/>
        <property type="gene ID" value="HS99_0032695"/>
    </dbReference>
    <dbReference type="OMA" id="VNVMAHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27028" checksum="05F4FD8A7EDC5493" modified="2017-01-18" version="1">MSEHGAFEGQGVVVTGAGRGIGAALARAFAASGARVVVNDLDAGAARAVAEDCGGVALPGDAASATGLAALVGRARAELGEIDVWCANAGVAPVGGADAPATAWASAWEVNVLAHVRAAELLLPHWLERGQGRFLATVSAAGLLTMLGSAPYAVSKHGALAFAEWLSATYQHRGVKVHALCPQGVRTDMLASTGAVGEALLAPTALEPEVVAGAALDALREDRFLILPHPETAEYYRVRATDPDRWIAGMNRLQQGLERSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K1</accession>
    <name>A0A1E7N4K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551202.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80817">
        <property type="protein sequence ID" value="ARF80817"/>
        <property type="gene ID" value="B6264_19590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35621">
        <property type="protein sequence ID" value="OEV35621"/>
        <property type="gene ID" value="HS99_0006820"/>
    </dbReference>
    <dbReference type="OMA" id="YEYPRYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="30012" checksum="9F67F4D0959CDA36" modified="2017-01-18" version="1">MTALSVREQAVHLLRRGISNAEVARRLRVPQGTVSWWKHQDLAKRNKLPGRKRSACMHCYGDELNRPAYSYLLGLYLGDGHILLPNEYRRTQSLQITCDDKWPGIMDSVEQAMREVLPNNKPCRVRRTGCHDVKAYSNHLTCHFPQHGPGKKHERSIALEPWQQEIVDTHPWQFLRGLIHSDGCRITNWATKTVDGVVRRYEYPRYFFTNTSTDIIGLFTATLDAVGVQWKASIPRLTGQVNISIARKDSVALMDAHIGPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U7</accession>
    <name>A0A1E7N4U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene861"/>
    <dbReference type="EnsemblBacteria" id="OEV35705">
        <property type="protein sequence ID" value="OEV35705"/>
        <property type="gene ID" value="HS99_0007330"/>
    </dbReference>
    <dbReference type="OMA" id="YDMIPLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="325"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="687" mass="74558" checksum="EE922D6830A7A490" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N507</accession>
    <name>A0A1E7N507_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000917.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene762"/>
    <dbReference type="EnsemblBacteria" id="ARF80987">
        <property type="protein sequence ID" value="ARF80987"/>
        <property type="gene ID" value="B6264_20610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35776">
        <property type="protein sequence ID" value="OEV35776"/>
        <property type="gene ID" value="HS99_0007835"/>
    </dbReference>
    <dbReference type="OMA" id="DTHRHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21810" checksum="07C7B4127054AFE0" modified="2017-01-18" version="1">MTVNTDDKNDLLIYVQDARDALMWKLEGLSEYDLRRPLTPTGTNLLGLIKHVTGAEALYLGETFGRPFPEPTPLWIIGTAEPNADLWARADESTEEILGRYRRVWAHSDATIEALPLDAIGQLPFGGRPKQTLHRVLVHVIAETHRHVGHADLVRELIDGATGQRSHGPNTAPGDTAWWQAHHDRVEQAARQAGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N565</accession>
    <name>A0A1E7N565_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0008080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737905.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000251_gene3"/>
    <dbReference type="EnsemblBacteria" id="ARF81029">
        <property type="protein sequence ID" value="ARF81029"/>
        <property type="gene ID" value="B6264_20855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35819">
        <property type="protein sequence ID" value="OEV35819"/>
        <property type="gene ID" value="HS99_0008080"/>
    </dbReference>
    <dbReference type="OMA" id="MVRITEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="32307" checksum="60CCDABADCB49D77" modified="2017-01-18" version="1">MAEILVLVDHAEGAVRKPALELLTLARRIGEPSAVVLGAGAAAADIAAKAAEFGAAKVYVADGAEFADQLVVPKVDALTQIAKANDVAGVLVTSSGEGKEVAARVALRLGSGIITDAVDVRAGDQGPVATQSVFAASYTVESRVSNGVPVITVKPNAVAPEAAPAAGAVENVSVEFTGNAARVTSRTPRVSTGRPELTEAAIVVSGGRGVGAAEGFGVVEELADALEAAVGASRAAVDAGWYPHSSQVGQTGKQVSPQLYVANGISGAIQHRAGMQTSKTIVAVNKDPEAPIFELADYGVVGDLFEVLPQLTAEVKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N571</accession>
    <name>A0A1E7N571_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0008075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366876.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000181_gene547"/>
    <dbReference type="EnsemblBacteria" id="ARF77562">
        <property type="protein sequence ID" value="ARF77562"/>
        <property type="gene ID" value="B6264_00240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81028">
        <property type="protein sequence ID" value="ARF81028"/>
        <property type="gene ID" value="B6264_20850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35818">
        <property type="protein sequence ID" value="OEV35818"/>
        <property type="gene ID" value="HS99_0008075"/>
    </dbReference>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="27143" checksum="5638037742E8829E" modified="2017-01-18" version="1">MSLRIVVCVKYVPDATGDRRFADDHTTDREGVDGLLSELDEYGVEQALRIAEANDGAEVTVLTVGPDDAKDALRKALSMGADKAVHVNDDDIHGSDVLATSAILAKALEKTGFDLVIGGMASTDGTMGVLPALLAERLGVPQVTLLSEVSVEGGVVKGRRDGDAATELVEAPLPAVVSVTDQSGEARYPSFKGIMAAKKKPVQSLDLDDLGIEADEVGLAGSWTAVDSVAARPARTAGTVVKDEGEGGKQLAAFLADQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I3</accession>
    <name>A0A1E7N5I3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene862"/>
    <dbReference type="EnsemblBacteria" id="OEV35956">
        <property type="protein sequence ID" value="OEV35956"/>
        <property type="gene ID" value="HS99_0007320"/>
    </dbReference>
    <dbReference type="OMA" id="AWGVRPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="13337" checksum="465C8A04ADEFA749" modified="2017-01-18" version="1">MHLTLDPADLVAVGAVRHRLRTALSHWGVPELSDTAELLTSELVTNALLHTAKGAVFDAALGSDSRLRVEVQDGTSRLPGRRRDPEAEYATSGRGLLLVEALADSWGVQLLGDGKVTWFELALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5S8</accession>
    <name>A0A1E7N5S8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0031675</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6349"/>
    <dbReference type="EnsemblBacteria" id="ARF78774">
        <property type="protein sequence ID" value="ARF78774"/>
        <property type="gene ID" value="B6264_07450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36057">
        <property type="protein sequence ID" value="OEV36057"/>
        <property type="gene ID" value="HS99_0031675"/>
    </dbReference>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="38757" checksum="8C0AC602861F72D6" modified="2017-01-18" version="1">MTADDRKMLLDPGFELTLRPMRYPSFYDRYRDAIKNTWTVEEVDLHSDVADLAKLSEGERHLIGRLVAFFATGDSIVANNVVLSLYKHINSPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPEDRNAAFAAVENIPSIHQKAQFCFKYMNAVDHIESLQTKEDRRAFLLNLICFAACVEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDESMHMDFAMSVVDTVREEEPDLFDDEMAKQVTEMLEEAVAAELQFAQDLCGDGLAGMNTDSMRQYLEAVADQRLARLGMPIRYGSTNPFGFMELQNVQELTNFFERRVSAYQVAVEGSVSFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N609</accession>
    <name>A0A1E7N609_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553608.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7273"/>
    <dbReference type="EnsemblBacteria" id="ARF81104">
        <property type="protein sequence ID" value="ARF81104"/>
        <property type="gene ID" value="B6264_21300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35893">
        <property type="protein sequence ID" value="OEV35893"/>
        <property type="gene ID" value="HS99_0008525"/>
    </dbReference>
    <dbReference type="OMA" id="DRVWFRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="43625" checksum="964CC52946486585" modified="2017-01-18" version="1">MVILVTRTPVSDRHRYDRATAHLDGPVAVVDLAAFDANAADLVRRAGGKPIRVASKSLRCRALLERVLAVDGFAGVMSFTLDESLWLARTGVRDVLLAYPSTDRAGYAELTADPELARRVTVVLDDPAQLDLIDKARSGDAEVRVCLELDTALHLLGGRVRVGARRSPLRTPEELGAFAEFVQRRRGFRVVGLMAYEGHVAGVGDRVPGRPVRSQLIRLMQARSRTELAERRAAVVRRLRQVVELEFVNGGGTGSVESTVAERAVTEVAAGSGLYAPQLFDNYRSFRGRPAALFGQPVVRRPGVGVVTVLGGGYPASGAAGPDRSPVPYLPAGLHYDPMEGAGEVQTPLIGPAADDLLIGDRVWFRHAKAGELCERFAELHLIEGDRVVRSVPTYRGEGRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T1</accession>
    <name>A0A1E7N6T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737879.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7788"/>
    <dbReference type="EnsemblBacteria" id="OEV36416">
        <property type="protein sequence ID" value="OEV36416"/>
        <property type="gene ID" value="HS99_0029165"/>
    </dbReference>
    <dbReference type="OMA" id="FDGYTVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="32127" checksum="726297F3174BF01C" modified="2017-01-18" version="1" fragment="single">AGVRPSGRRRHRPGPPGPAGVRLRWLGNNGWEISFGDPDRPTTILIDPWITRFPTGTYTPKGADPATPLSVDTALIDSLRLRADQILVTHGHYDHLSDVPYLAARTGATVLGTETHANLLAALGAPEDQLSMVHGGEYLQFDGYTVQVINSLHSMTGPRSKVPFPGTRPGSPPPRPRVISDLVEGGTLAYLITVGDKLSILDSGGANYDARHLTGLTPDVLLLQPGGASVPDYVPRLLDVLDHPPYVVPTHWDDFDHPLNEPARDWGGLAELEAAVHRADPEARFLRLDHLESFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T6</accession>
    <name>A0A1E7N6T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7741"/>
    <dbReference type="EnsemblBacteria" id="OEV36388">
        <property type="protein sequence ID" value="OEV36388"/>
        <property type="gene ID" value="HS99_0029980"/>
    </dbReference>
    <dbReference type="OMA" id="RQFRNRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="470" mass="49999" checksum="280FE1E7A2912FBE" modified="2017-01-18" version="1">MTDSGNTTGRRKFTVPGFATGPDGRAQRAREQGKALRVPVPRERHSEFVPAADRPTAVAALEASNAGRIAGLVPIRVGRMAATPFAFLRGSAGLMAADLAGTPVTGVTAQLCGDAHAANFGLYGDARGQLVMDINDFDETVPGPWEWDLKRLATSLVLAGRETGASESTARAAAQHAAGSYRRTLRTLAKLPALDAWNAVADEQLVSFAEAHDLTEVLRKVGAKALGNTSARFAARSTTRTADGGWRFTAAPPVLTGVTDATARAVAEALGPYVATVPAEVRTLLSRYRVQDVAFRVVGTGSVGTRSYVVLLTDHRDQPLVLQVKEARPSVLLPYLGGHWRRPAEEHEGRRVVLGQKHMQVVSDTLLGWTTVDGRPYQVRQFRNRKGSVDPAVLLPSQLDDYARITGALLARAHAHTADPGLLAGYCGKSEALDEAVAAFAVAYADRTEADHAELVAAVRSGRLPAEQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E3</accession>
    <name>A0A1E7N7E3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mqnB</name>
        <name evidence="2" type="ORF">HS99_0029145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386228.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7924"/>
    <dbReference type="EnsemblBacteria" id="ARF79110">
        <property type="protein sequence ID" value="ARF79110"/>
        <property type="gene ID" value="B6264_09440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36588">
        <property type="protein sequence ID" value="OEV36588"/>
        <property type="gene ID" value="HS99_0029145"/>
    </dbReference>
    <dbReference type="OMA" id="MEGYGVA"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="24806" checksum="4D5D54E1AC8E9080" modified="2017-01-18" version="1">MTAHVVDAHPGQPGPERARLLVVVAVPAEAEAVLRGLPGGAEAVPLPGGVLHRCAGAPVDVLAAGVGPAAAAAAASAALAARPYGLVASAGIAGGFAPHAPVGATVLADAIVVADLGAETPEGFADVTELGFGTVRHTPPPAVVALAGKALGTRDVDAVTGPVLTVSTVTGSTERAAALAARHPGAAAEAMEGFGVAEAAARYGVPVFELRTVSNPVGPRDRAAWRIGEALAALERAFAALPVRELIEEAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H5</accession>
    <name>A0A1E7N7H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0028125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2543"/>
    <dbReference type="EnsemblBacteria" id="OEV36641">
        <property type="protein sequence ID" value="OEV36641"/>
        <property type="gene ID" value="HS99_0028125"/>
    </dbReference>
    <dbReference type="OMA" id="NLANDRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="21865" checksum="57434C8B56557B79" modified="2017-01-18" version="1">MQLVRLGRRGRDARRIDFVEFVQQRSAALFRTAYILTGSQDSAEDLLQEALEKACRHWNRVAVADSPEAYVRRIVVNLANDRWRRLRRIGERSHDVEHADPRDPYRLVDLRDELVQALHALPIGMRSVVVLYYLHDMGDREIAEALRISPGSVRSQLARGLARLRTAVPQPEPPPPAPDGHRTAPLPQFEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L1</accession>
    <name>A0A1E7N7L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide N-methyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278901.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000813.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2519"/>
    <dbReference type="EnsemblBacteria" id="OEV36658">
        <property type="protein sequence ID" value="OEV36658"/>
        <property type="gene ID" value="HS99_0028240"/>
    </dbReference>
    <dbReference type="OMA" id="ILNCELN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="23785" checksum="A78C3558990EE136" modified="2017-01-18" version="1">MPSELRTLRADADPAFIRRETELTPVPFVPEIRLHMAQDAIALWETTERERGRDGLPPPFWAFAWAGGVAVARYVLDHPELVDGRAVLDIAAGSGLVGVAAALRGAKEVRAAEIDAYAVAAIELNAEANGVRVAGALVDLVDGDGAPAEVVLAGDVFYERAMAARFLPFLERAAARGATVIVGDPGRAYLPRERFTAVAAYQVPVVADLEDASVKTTTVWRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M8</accession>
    <name>A0A1E7N7M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385826.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2477"/>
    <dbReference type="EnsemblBacteria" id="ARF81521">
        <property type="protein sequence ID" value="ARF81521"/>
        <property type="gene ID" value="B6264_23725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36691">
        <property type="protein sequence ID" value="OEV36691"/>
        <property type="gene ID" value="HS99_0028440"/>
    </dbReference>
    <dbReference type="OMA" id="FTHMIVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21508" checksum="66BB1C157973F34F" modified="2017-01-18" version="1">MATDRDTVLEAAVGVLSRRPTAHLDEIARAAGISRATLHRLFPGRDALIRDVGRLGLQRFAAALDTAAVEEGDARTALRRLVDAAVPDAMLCAFLAGENQLYDDDEINDLWEVQIDRLHALFLRGQREGVFRIELSAAWLSEAFFDLVAGIGWAIQDGRLAPRDAAFSLAELFLGGALRRDPTPSNPQHLGPETGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T5</accession>
    <name>A0A1E7N7T5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000482.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4773"/>
    <dbReference type="EnsemblBacteria" id="OEV36750">
        <property type="protein sequence ID" value="OEV36750"/>
        <property type="gene ID" value="HS99_0027425"/>
    </dbReference>
    <dbReference type="OMA" id="AGFQFEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23840" checksum="25CBAE64F2A617A0" modified="2017-01-18" version="1">MSSEIYFSDNYRDLCEKYGTGAGFQFEFYCYRCSDTWRSPFERFTTGQVAGWIGKGVNAAWNLIGGNANTISNAADGLAGQTWGTSRDAAFQRAIANAQSHFNRCARCTHYVCGRCFTPEQGLCLTCAPDTAAEAAAAQRRGLNDMVTDRAYQVGQQSGAEFDVRTPTQLVCPQCRAETHGTPFCPGCGFRLAQPVQCGQCHKDVPEGAAFCPSCGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N885</accession>
    <name>A0A1E7N885_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366569.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6855"/>
    <dbReference type="EnsemblBacteria" id="ARF78645">
        <property type="protein sequence ID" value="ARF78645"/>
        <property type="gene ID" value="B6264_06720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36907">
        <property type="protein sequence ID" value="OEV36907"/>
        <property type="gene ID" value="HS99_0026970"/>
    </dbReference>
    <dbReference type="OMA" id="HWFGNDR"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="42202" checksum="783E843E629DC08F" modified="2017-01-18" version="1">MRRRVGVWARRVVAAWCVLVVAGCGGGVSGGSGGDVAGVGSRTPPPAPSRAVVTAVPADGAQDVAAEGAVRVTVGQGRLVSVRLADAKGVELPGTIGPDGAAWVPDGPLPLGTAFTLDAVAEDDQGQRAAQHSAFSTVARAHTFVAFFTPEDGSTVGVGMPVSLRLSRPITDRAAVERAVRVTADPPVPVAAHWFGNQRLDFRPRQYWAAGTRVTVALRLKDVQGAPGEFGTQSRDLHFTVGRAQVSTVDLDAHTLTVRAGQGGKVLRVLKVSGGSPDHPTYRGVMVVSEKYKLTRMNSQTVGMGDEYDIKDVPHAMRLTASGTFVHGNYWADPGVFGTANLSHGCIGLADVKGGTGKDTPAAWLFEHTIPGDVLEVRASAGDFVPPSNGLGDWNLPWEQWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8V9</accession>
    <name>A0A1E7N8V9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0004570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6688"/>
    <dbReference type="EnsemblBacteria" id="OEV37098">
        <property type="protein sequence ID" value="OEV37098"/>
        <property type="gene ID" value="HS99_0004570"/>
    </dbReference>
    <dbReference type="OMA" id="DRNVRGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="60"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="380"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="643" mass="68706" checksum="BB0A52218F04BDB6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N914</accession>
    <name>A0A1E7N914_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556612.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000238.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81555">
        <property type="protein sequence ID" value="ARF81555"/>
        <property type="gene ID" value="B6264_23945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37181">
        <property type="protein sequence ID" value="OEV37181"/>
        <property type="gene ID" value="HS99_0005040"/>
    </dbReference>
    <dbReference type="OMA" id="LFAWQGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16321" checksum="E87C747AC57C0376" modified="2017-01-18" version="1">MTTEAELLTSDDQRLEELFRKSSAGEIPRGPMEGLAVFPAAGRAGARLLASLVNLTAWRGKVFSPDGYLSNRLTAMDILSIVATVGPGPSRLDDQECIVIDYSHTSLVFGGVRDELRQVGPGLYLGLIWLAGRKIGWFTLRDPANAENSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L9</accession>
    <name>A0A1E7N9L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556383.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5402"/>
    <dbReference type="EnsemblBacteria" id="ARF82497">
        <property type="protein sequence ID" value="ARF82497"/>
        <property type="gene ID" value="B6264_29755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37382">
        <property type="protein sequence ID" value="OEV37382"/>
        <property type="gene ID" value="HS99_0006280"/>
    </dbReference>
    <dbReference type="OMA" id="QHELHRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="41782" checksum="54D63371ECFEDD4D" modified="2017-01-18" version="1">MKHRIVVLGAGYAGAFAAGNLARRLSPADTEITVVNAVPDFVERMRLHQLAIGQDLAFRKLADVFAGTGVRLRLARVTGVDPERRTVAVTGEDGDGELAYDTLLYALGSSVAHHGVPGVAEYAFDVTGRSSALRLRERLAGLGEGGTVLVVGEGLTGIETATEFAESRPDLSVALAARGELGAWLSPKARHHLRQAFDRFGITVHEHTAIEAVEPTRAIAADGTAVPADVTVWSAGFAVHPIAAASGLEVAETGQIVVDRTMRSVSHPDVYAAGDSAYAIGDNGRPLPMSCGSAGYTNMQATAAIIARLTGSKVPTTALKYYGNTISLGQRDAILQTVDEEARSKSWYLGGRPAARLKSGVLKGSRWSIAHPTFGMPKRKRRLAIAKDRSDAPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M5</accession>
    <name>A0A1E7N9M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481690.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000093_gene117"/>
    <dbReference type="EnsemblBacteria" id="ARF82514">
        <property type="protein sequence ID" value="ARF82514"/>
        <property type="gene ID" value="B6264_29870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37400">
        <property type="protein sequence ID" value="OEV37400"/>
        <property type="gene ID" value="HS99_0006390"/>
    </dbReference>
    <dbReference type="OMA" id="ICELHAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="22751" checksum="B063EB22EED936C6" modified="2017-01-18" version="1">MRSDARDNRARILDAARAVFGEEGLSAPMREVARHAGVGPATLYRHFPTKQALFAETFAEQRRACHAAVRDALTDSNPWHGFRSLIERICELHAHSRGFADAFMTAFPEAMDFAADRERTLHAVRELARRAQKTGQLRPGFVVDDLVLMLMAHRGLQDTPRAARVTASRRFAAYMIEAFSAAPATGAPTPLPPAPRLQLTHSPSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA85</accession>
    <name>A0A1E7NA85_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284173.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8017"/>
    <dbReference type="EnsemblBacteria" id="ARF79863">
        <property type="protein sequence ID" value="ARF79863"/>
        <property type="gene ID" value="B6264_13970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37610">
        <property type="protein sequence ID" value="OEV37610"/>
        <property type="gene ID" value="HS99_0025185"/>
    </dbReference>
    <dbReference type="OMA" id="MADERHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15033" checksum="B7967D0239CA43F2" modified="2017-01-18" version="1">MADERHAPASGDAPARRRGQGELEAQVLAVLQQAPGPASAGWVQERLEGDLAYTTVMTILSRLHAKNAVSRSRSGRSYLWQASSDAAGLAALRMRRMLDGEADRDAVLASFVTALLPHDEELLRALLDAASADPAAADRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA91</accession>
    <name>A0A1E7NA91_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAP2_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0025210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366726.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8012"/>
    <dbReference type="EnsemblBacteria" id="ARF79868">
        <property type="protein sequence ID" value="ARF79868"/>
        <property type="gene ID" value="B6264_13995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37615">
        <property type="protein sequence ID" value="OEV37615"/>
        <property type="gene ID" value="HS99_0025210"/>
    </dbReference>
    <dbReference type="OMA" id="CMFRSAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PAP2_3" evidence="5">
        <location>
            <begin position="148"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="37031" checksum="7CBDF24EEB26B913" modified="2017-01-18" version="1">MTKLLSPAPPSPVRAGRLRPVSDRDRRTGLSRLRLLAWPAYLTAFVWFVATQGMAFANDVVFLWLIGALLTAAVHSGHGGRGFLLVLRDWIPVMAVVWVYSLLRGYGAQTPWAPHWLPQLRADELLGSGETWTVRLQQALYTPGSPHWYDYAATAVYLSHFLVVFVLLAVLWRRSHRRFRQLLACYFTLTFAGFATYLLYPADPPWLVAQQGNLPPLHRVVWETISAMGLPQADSLLENGSQFANDVAAMPSLHSAYPAMLLFLFWPAAGRTLRALLVAYPLAMAFTLVYGAEHFIVDVLVGWTYAAVVVFGLRLLRNRRTARAAAEADLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA93</accession>
    <name>A0A1E7NA93_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551564.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8025"/>
    <dbReference type="EnsemblBacteria" id="ARF79856">
        <property type="protein sequence ID" value="ARF79856"/>
        <property type="gene ID" value="B6264_13930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37602">
        <property type="protein sequence ID" value="OEV37602"/>
        <property type="gene ID" value="HS99_0025145"/>
    </dbReference>
    <dbReference type="OMA" id="WVLPFEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="24069" checksum="4FA48A1FED6A5681" modified="2017-01-18" version="1">MTGAATLLAATGSLEPAARSFLSPTGQEIVFLLVGIAVLGSAVASVTTKQLVHAALWLVVALGGLAVEFLLLTAEFIAWVQVLIYLGSVIVLVLFGLMLTKAPIGRSPDADSKNRWVALVVALASAGTLVTLVVDAFRTSWIDLGAGGGSAAVTGASLFRNWVLPFEALSVLLLAALVGAIVLSRGAKRRVPAPRAGRLRAGRPVGSNGTVAATAPRTAPEAAAPSAPSTPSVTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL7</accession>
    <name>A0A1E7NAL7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553124.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4916"/>
    <dbReference type="EnsemblBacteria" id="ARF79988">
        <property type="protein sequence ID" value="ARF79988"/>
        <property type="gene ID" value="B6264_14670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37729">
        <property type="protein sequence ID" value="OEV37729"/>
        <property type="gene ID" value="HS99_0025880"/>
    </dbReference>
    <dbReference type="OMA" id="WGAGRIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="559" mass="57597" checksum="22232AF5030D25CA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ9</accession>
    <name>A0A1E7NAZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6031"/>
    <dbReference type="EnsemblBacteria" id="OEV37870">
        <property type="protein sequence ID" value="OEV37870"/>
        <property type="gene ID" value="HS99_0024935"/>
    </dbReference>
    <dbReference type="OMA" id="NPDWIQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="58"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="36079" checksum="66761B8BA253A4A0" modified="2017-01-18" version="1">MAAAVALLVTGCGSGGSAESGDAGATAANGGASSAAAAPVKVTDCAGKETVFDSAPKKIVTSNASSLEMLLKLGAGDRVIGTGFPPGKGTLPADVADAGAKVPVLGDMVIPKEKLLGSGADLYVETFADMGGMGGGMGTAPTAQEYQAAGIKRVFLHSTACAATAPTTVRDLTGVEGDIKSLGQVTGTSAKADALVADMEKKVGAVKTALAGVAADKRPGYFFFDFDAGTKQPMAVGNRQVANAVITLAGARNVFGDVDGDFKPVSWEDVVARNPDWIQLGVRNRGSDAENKKAFDDAEKFLREFPATKGLKAVQEGHFVRIGSEVTTIAGTRNADTVQQIAHTLFPDQVKDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB72</accession>
    <name>A0A1E7NB72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552068.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000452.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79496">
        <property type="protein sequence ID" value="ARF79496"/>
        <property type="gene ID" value="B6264_11735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37942">
        <property type="protein sequence ID" value="OEV37942"/>
        <property type="gene ID" value="HS99_0024060"/>
    </dbReference>
    <dbReference type="OMA" id="LELNAGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="31847" checksum="44C4337CCEF2700F" modified="2017-01-18" version="1">MRTSVINRFAKNDRAFSGRRRIAVLAATAVLAGGVQVLAMSDTAWACGDARFGTSPVFDPSVRKPTVPNSDFRDPLSNSLAADGSWTEFGVGMTNFTGADVAKAAPSFSLSGTSLRTRDVRVEVEQNGSWKPLELNAGCIGIDADTDSLAQPLANGRAADFVFRVSLSPASPKDLSTLTLVTDAVTDKATLEYWGNRTVKVTHPRTAPTTGKPTPAAKPAPAKPAPAEQTAAKQAAEKTEQPSAGSPAPQATPSAPAATAPAGTAELAHTGSSGTDTFLATSAAALLALGAGVLLVVRRLRRLRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB91</accession>
    <name>A0A1E7NB91_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1699"/>
    <dbReference type="EnsemblBacteria" id="OEV37743">
        <property type="protein sequence ID" value="OEV37743"/>
        <property type="gene ID" value="HS99_0025475"/>
    </dbReference>
    <dbReference type="OMA" id="GWAVMPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="539" mass="55871" checksum="287AA67C160249D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB95</accession>
    <name>A0A1E7NB95_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsF</name>
        <name evidence="9" type="ORF">HS99_0023930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278276.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2094"/>
    <dbReference type="EnsemblBacteria" id="ARF79475">
        <property type="protein sequence ID" value="ARF79475"/>
        <property type="gene ID" value="B6264_11600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37924">
        <property type="protein sequence ID" value="OEV37924"/>
        <property type="gene ID" value="HS99_0023930"/>
    </dbReference>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10933" checksum="1AF06354337AF300" modified="2017-01-18" version="1">MRHYELMVILDPSVEERAVSPLIESFLAVVRNGGGKVEKVDTWGRRRLAYEINKQSEGIYSVIDLKATPEVVKELDRQLGLSESVLRTKVLRPDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ5</accession>
    <name>A0A1E7NBJ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387126.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000685.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3040"/>
    <dbReference type="EnsemblBacteria" id="ARF79729">
        <property type="protein sequence ID" value="ARF79729"/>
        <property type="gene ID" value="B6264_13180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38061">
        <property type="protein sequence ID" value="OEV38061"/>
        <property type="gene ID" value="HS99_0022920"/>
    </dbReference>
    <dbReference type="OMA" id="FRHGGFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="29880" checksum="ACBE54DAEDCB7EAC" modified="2017-01-18" version="1">MAASFDPATAAPARGRAGRPVGTVTRGTTNTNRLRRMDRWIAHTLGRTLRAAERPPVAVDLGYGAAPWTAVELAGRLRTVRPDVRVVGIEIEPERVAAALPYAEPPLLTFRRGGFEVPLDGGGPAQLIRAANVLRQYDESAVPGVWERLCSRLAPDGLLVEGTCDEIGRRHVWVALGPEGPRTVTFAARLGGLVQPSDLAERLPKALIHHNVPGRPVHAFLTDFDRAWAAAAPYGAFGARQRWVAACTALAGSWPLVDARGRWRQGEVTLPWTALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT7</accession>
    <name>A0A1E7NBT7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737819.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene455"/>
    <dbReference type="EnsemblBacteria" id="OEV38159">
        <property type="protein sequence ID" value="OEV38159"/>
        <property type="gene ID" value="HS99_0023505"/>
    </dbReference>
    <dbReference type="OMA" id="PQCRGDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="36640" checksum="C6E8DEC3D704EFE7" modified="2017-01-18" version="1">MSSRESDNANPTPRRTGPDAYPSGTPPYGTPGLPGGDRAAAGTDAGSGGEDDGPRTETTLTTRVRINIPGSRPIPPVVVRSTVKNETAKGDEGPAEQAPPGEPGGPRHRSAPASPVLGVMEGGRSATPPNLPPEWQIPPIPPATSESESTGAWFRPRQKKAPAAEPAPATVASGAPSAPEAPAVPGAAEARPQGAPNGTRPTPATDAPRPNGRPVPAQGKAPKPGAAPSPASPYGAGPAGEEPGVYEAAAPFAPVADPFAPVADPFAHVRHQLSAEPDGHPERQPHLRAGHRHHRPHPGAGQPGGRDGLAAGRLRGDALPGRRAAGRRRRGPADRGPRGGLSARPGRTGVRRRTLWSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC32</accession>
    <name>A0A1E7NC32_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0022145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558056.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000650.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1748"/>
    <dbReference type="EnsemblBacteria" id="ARF80237">
        <property type="protein sequence ID" value="ARF80237"/>
        <property type="gene ID" value="B6264_16135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38247">
        <property type="protein sequence ID" value="OEV38247"/>
        <property type="gene ID" value="HS99_0022145"/>
    </dbReference>
    <dbReference type="OMA" id="VVTSTTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24575" checksum="C0604E7F3151F3A9" modified="2017-01-18" version="1">MSVLSVLDPAVTVAHAVVSAIAHVLPTALAIVLFVLAVRLCLHPLARAAARGEKARSKLAPKVAELNKKHRNSPEKAREALAELYRKEQVSPFAGCLPMLVQIPFFSVMYRLFTTPNDLLDHTLFGVPLGLHVGNAHGAGQFAVFGLLYAGLAAVGYVNYRRARRAAAAAQTTPQPGAALLPYLSFASVLFAVLVPVAAGLYLLTTSVWSASERAWLYRGTNQAPAAALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD4</accession>
    <name>A0A1E7NCD4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553252.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4156"/>
    <dbReference type="EnsemblBacteria" id="ARF80164">
        <property type="protein sequence ID" value="ARF80164"/>
        <property type="gene ID" value="B6264_15700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38314">
        <property type="protein sequence ID" value="OEV38314"/>
        <property type="gene ID" value="HS99_0022570"/>
    </dbReference>
    <dbReference type="OMA" id="TSLFGMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="479" mass="48606" checksum="D01284739F9FC899" modified="2017-01-18" version="1">MTTASPTSVDSTPIPDGTDPGGGVLGGRYRALTLGIVSVVLVIAFEATAVNTAMPTAARQLNGLGLYAFAFSGYFTTTLFALVVSGQWCDRRGPLRPLFTGIAVFGAGLVVAGTAPGMWVFVAGRAIQGLGGGLVIVALYVVVGRAYPERLRPSVFAAFSSAWVLPSIVGPLVSGAVTQHLGWRWVFLAVPVLILLPLAVMGPTLARSEREHPVLRGADFDRRRTLLAAMAAVGAGLLQYAGQRRDLVGLLPGIAGAALLVPAVLGLLPKRTLRAGRGLPTVILLRGVAAGAFFAAEAFIPLMMTTERDFSPTLAGLTLTSGGLSWALGSWLQGRPGAERYRGAMIRGGFVLTAVAIAGAALVLIPAVPSWTASVAWGVGGVGMGLTVASVSVLMMRLSAPEDAGANSAALQMSDALGNVLLTGLAGVLFAALGGGSLAAAHEGAGDGGSPAAFAVILLVMASVAVLGALLSGRVRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCH2</accession>
    <name>A0A1E7NCH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366393.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene254"/>
    <dbReference type="EnsemblBacteria" id="ARF82219">
        <property type="protein sequence ID" value="ARF82219"/>
        <property type="gene ID" value="B6264_28065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38390">
        <property type="protein sequence ID" value="OEV38390"/>
        <property type="gene ID" value="HS99_0020990"/>
    </dbReference>
    <dbReference type="OMA" id="STDRICG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24403" checksum="C4D082D9A912AEA3" modified="2017-01-18" version="1">MKRWKPWHGALALALVATVTAGLLWWQPWHDEPAPLAFTTAPGGSARFGTGEHLYRYKVRVEDGIRESPEQFAAEVDAILGDTRRGWAAGNTASFQRMPADPVDFTVYLASPSSTDRICGQYGLDTGGWVNCGVQHQVVINLERWTELSEFYQGRPELYHALAVNHEVGHILGNGHVDCPGPGAPAPVMMQQIKGLHGCVPNGWPYSDAGTLLTGPPVQAPSNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCK3</accession>
    <name>A0A1E7NCK3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554499.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000276.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene288"/>
    <dbReference type="EnsemblBacteria" id="ARF82187">
        <property type="protein sequence ID" value="ARF82187"/>
        <property type="gene ID" value="B6264_27890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38422">
        <property type="protein sequence ID" value="OEV38422"/>
        <property type="gene ID" value="HS99_0021165"/>
    </dbReference>
    <dbReference type="OMA" id="GWCLCSQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="541" mass="58069" checksum="77458A2F01855C7A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCN9</accession>
    <name>A0A1E7NCN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366399.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000830.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene281"/>
    <dbReference type="EnsemblBacteria" id="ARF82195">
        <property type="protein sequence ID" value="ARF82195"/>
        <property type="gene ID" value="B6264_27930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38414">
        <property type="protein sequence ID" value="OEV38414"/>
        <property type="gene ID" value="HS99_0021125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="21832" checksum="6AD4697BEBCCB73B" modified="2017-01-18" version="1">MPALFPPAVLLGGYVLLWLLGFLACALHQSRRPVAVGADYLVVLGAALDGCEPAPILAARLDAALEHLAAEEAAGHAALLLVTGGKGPHEECTEAGAMARYLIARGVPAERIRREERAVNTAENLRFSAALMAAERPGYRCTVVTSGFHTVRSALAARRAGAPGRVLGADGPLAHGPYQLLREAVGTALAVPRVNGAALLLLTGTGVVLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW2</accession>
    <name>A0A1E7NCW2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene701"/>
    <dbReference type="EnsemblBacteria" id="ARF77569">
        <property type="protein sequence ID" value="ARF77569"/>
        <property type="gene ID" value="B6264_00295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38546">
        <property type="protein sequence ID" value="OEV38546"/>
        <property type="gene ID" value="HS99_0019880"/>
    </dbReference>
    <dbReference type="OMA" id="PAYAPWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="30209" checksum="417905283D2A2627" modified="2017-01-18" version="1">MSLRKPSAVLPLAALVVAAAALTGCAPQDAKSDGAAASGASGSARTAAGCAPGALATRTAGKLTIGTDKPAYDPWFSGDEPANGKGFESAVAYAVAEKLGYPKDKVGWVVAPFGKATAPGAKDFDFDINQVSISDERRQAVDFSSGYYSVRQAVIALKGSKAAGAKSIADLKDAKLGAQIGSTSLDTITNAIKPSGQPAVFDSNDLAKAALKNGQVEALVVDLPTAFYITGAEVPEAQVVGQFESAAQGEQFGLVLDKGSRLTSCVSGAVDALRADGTLEKLEKQWLSDAVSAPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ5</accession>
    <name>A0A1E7NCZ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281315.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene684"/>
    <dbReference type="EnsemblBacteria" id="ARF77583">
        <property type="protein sequence ID" value="ARF77583"/>
        <property type="gene ID" value="B6264_00380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38560">
        <property type="protein sequence ID" value="OEV38560"/>
        <property type="gene ID" value="HS99_0019965"/>
    </dbReference>
    <dbReference type="OMA" id="LWVDTEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="44287" checksum="9B73CF74BA691295" modified="2017-01-18" version="1">MRRGIAASALVVALAVSMAACGSSGGSGSDSKADGPVTLTYWDTSNATNEAPNYQELAKKFEAANPNIKVNFVNVPFDQAQNKLQTAMGAKGAPDVFRSDVGWTAAFAKAGFLEPLDGTPAAADTSAFQPSLIQQAKYDGKLYGVPLVTDTLGFLYNKDLFAKAGITDAPKTWDELKTDAATIKDKAGVDGFWLKAADGYYAMPFLFGEGTDTVDAANKKITITSPEAVKGIETYKSMFTSPGTAKADVTTDAYAHMMDAFNSGKVAAIIQGPWEITNIYKGSAFADKKNLGIAPVPAGSGGKAGAPTGGHNIAVYAGADKAHKAAAEKFAAFMTSAESQAFIAQKNSTLPTRSDAYTADVKADPGIAGFQAILGSAKPRPELPEYGSLFDSLGTNLGKAVQGTSTQDALNTVATDYAKLLPGFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL4</accession>
    <name>A0A1E7NDL4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737800.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene652"/>
    <dbReference type="EnsemblBacteria" id="ARF77608">
        <property type="protein sequence ID" value="ARF77608"/>
        <property type="gene ID" value="B6264_00540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38583">
        <property type="protein sequence ID" value="OEV38583"/>
        <property type="gene ID" value="HS99_0020125"/>
    </dbReference>
    <dbReference type="OMA" id="FFEWHRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="23566" checksum="C47E999DCDD0E8CD" modified="2017-01-18" version="1">MTTAPLLVLCALGPEVWALRGGDWRGAVGGPPVLVRTGVGRRRAGTAVRRLLNSARGGYGAVVVAGFGAAVGPGVAPGDVVAADGVRDAEGHLYPVDSGPELARALKEQGLTVHIGVHHTADHVVRGIERRALHLQGALAVDMEAAAVLAALREVRPVLPVAVLRVVVDTPEHELLRPGTLPAGVRAWRTLRATVPALVDWYRQEPVDGSADLNHPTSSTLPQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN6</accession>
    <name>A0A1E7NDN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-(1-2)-phosphatidylinositol mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0018910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553660.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7333"/>
    <dbReference type="EnsemblBacteria" id="OEV38748">
        <property type="protein sequence ID" value="OEV38748"/>
        <property type="gene ID" value="HS99_0018910"/>
    </dbReference>
    <dbReference type="OMA" id="VCPYSWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="41958" checksum="3BAC1C92E70250EA" modified="2017-01-18" version="1">MKIGIVCPYDWDVPGGVQFHIRDLAEHLIGLGHEVSVLAPAEDEEALPPYVVSAGRAVAVPYNGSVARLSFGILSAARVRRWLREGHFDILHVHEPASPSLSMLAAWSATGPMVGTFHTSNPRSRAMIAASPILQPGLEKMRARIAVSEYARRTLVEHLGGDAVVIPNGVDVGFFAGAEPDERWTGRAAAGEPGTIGFIGRINEPRKGLPTLLAALPRILAERPGVRLLVAGKGDEEEAVAGLPPEVRGQVEFLGMVSDREKARLLRSVDLYVAPNTGGESFGIILVEAMSAGAPVLASDLDAFKQVLDGGDAGELFPVEDADALARTALRLLGDPARLEELSKAASRHVRRFDWSTVGADILAVYETVTAGAAAVVEEDVRSGRRGRFGLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC4</accession>
    <name>A0A1E7NEC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000248.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene992"/>
    <dbReference type="EnsemblBacteria" id="ARF83300">
        <property type="protein sequence ID" value="ARF83300"/>
        <property type="gene ID" value="B6264_30675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39066">
        <property type="protein sequence ID" value="OEV39066"/>
        <property type="gene ID" value="HS99_0018390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13644" checksum="5EBE0D2366252D08" modified="2017-01-18" version="1">MRRVLQRVDGDALDAAIGAWLAARDTGGPPPDQGPGECLRRSLTVDGKTVRGARRPDGTQVHLLAAMTGTGLVAAQREVDRQRRAERLYPLQHHQLLHFRAQVADLISRPTVPLALVARGTVGSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC9</accession>
    <name>A0A1E7NEC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556321.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5124"/>
    <dbReference type="EnsemblBacteria" id="ARF81246">
        <property type="protein sequence ID" value="ARF81246"/>
        <property type="gene ID" value="B6264_22185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38843">
        <property type="protein sequence ID" value="OEV38843"/>
        <property type="gene ID" value="HS99_0019450"/>
    </dbReference>
    <dbReference type="OMA" id="KLLWNFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04215">
        <property type="entry name" value="choice_anch_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="441" mass="42675" checksum="97BFFFC8E6725596" modified="2017-01-18" version="1">MRIFTSAAALAVGGSLALAGLIAPAAQAVGAVGADQECRSLGVANLYGEFIEGDDTHTPDAEGAVAVGGNANFTGGFSVGQELTAAEVDALPGKNALVVAGKITGNNTQVMKGNGIYGSKADGAVVQAHAGAVSQGASPIDFEAEFAKLRSAAAELAAVPQTAGATVQADGPKLAFTGGDAKYNSFTVDAVTLQGAKEIYLKVPAGAVTVVNVTGGAYDMAAAGTTDFHLWDEEKSAFVLDDKLRSAAGGAIRAKLLWNFPSATKVVKNSAAAWAGTVLAPNAAFDLGSGGPVNGSVIAASLTGKGSAETHHYPFTGCLPGTTVPTPTGTPTVPPVTPSGSPTAPVTPSATTGPSGTPGVPGTGKPSTSASASPGPSSSRSSAAPAAPSASAGPSAPSSTGDSLAHTGSGPVLPLAIGGGVALAAGGGIVLAARRRAARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED9</accession>
    <name>A0A1E7NED9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Error-prone DNA polymerase</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaE2</name>
        <name evidence="12" type="ORF">HS99_0018350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-C family. DnaE2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557488.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1001"/>
    <dbReference type="EnsemblBacteria" id="ARF83292">
        <property type="protein sequence ID" value="ARF83292"/>
        <property type="gene ID" value="B6264_30635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39059">
        <property type="protein sequence ID" value="OEV39059"/>
        <property type="gene ID" value="HS99_0018350"/>
    </dbReference>
    <dbReference type="OMA" id="VAKSHHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01902">
        <property type="entry name" value="DNApol_error_prone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023073">
        <property type="entry name" value="DNA_pol_error_prone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294:SF4">
        <property type="entry name" value="PTHR32294:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV39059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1097" mass="118306" checksum="F0250F8CEFA5A400" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF2</accession>
    <name>A0A1E7NEF2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4070"/>
    <dbReference type="EnsemblBacteria" id="OEV39079">
        <property type="protein sequence ID" value="OEV39079"/>
        <property type="gene ID" value="HS99_0018495"/>
    </dbReference>
    <dbReference type="OMA" id="GFRIVWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIIM" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="12202" checksum="0182C20525A9970B" modified="2017-01-18" version="1">MLLAGRLKMTLSEEKTHITHIDDGFVFLGFHIQAKTRGDGRRVVLTIPSKQALASVMHKIKKLTERGTTLLSLEAVLRTVNPVLRGWAAYFRYGASRRRSPTSATLPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER0</accession>
    <name>A0A1E7NER0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000865.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000112_gene4047"/>
    <dbReference type="EnsemblBacteria" id="ARF83355">
        <property type="protein sequence ID" value="ARF83355"/>
        <property type="gene ID" value="B6264_31035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39128">
        <property type="protein sequence ID" value="OEV39128"/>
        <property type="gene ID" value="HS99_0018765"/>
    </dbReference>
    <dbReference type="OMA" id="ITRRRYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11876" checksum="6545EA0BC7783F5B" modified="2017-01-18" version="1">MAGKRRSYDAEFRAGAVRIVTETGKSAAEVARDLGVHESTLQNWVHRARTRADAEAAGGLSESERDELRRLRDENARQRKEIAELGMERDVLKRSVVLWVKEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER5</accession>
    <name>A0A1E7NER5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285083.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3468"/>
    <dbReference type="EnsemblBacteria" id="OEV39162">
        <property type="protein sequence ID" value="OEV39162"/>
        <property type="gene ID" value="HS99_0000040"/>
    </dbReference>
    <dbReference type="OMA" id="AMFTSIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10228" checksum="7687690927AE65E3" modified="2017-01-18" version="1">MIAAFSVTPLGIGEDVGEAVAAAVRVVRASGLPNRTDAMFTSIEGEWDEVMPVIRAAIEAVKAHSNRVSTVIKIDDRAGVTDGLTAKVASVERHLANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NET1</accession>
    <name>A0A1E7NET1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285190.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3522"/>
    <dbReference type="EnsemblBacteria" id="OEV39207">
        <property type="protein sequence ID" value="OEV39207"/>
        <property type="gene ID" value="HS99_0000295"/>
    </dbReference>
    <dbReference type="OMA" id="AAMEVWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="22098" checksum="A7F41E4851416432" modified="2017-01-18" version="1">MTNGQPGLRERKKAATREALSWAALRLAVERGLENVRVEDIAAAAGVSPRTYNNYFSSKAEAIVFRHRSRILRAAEALRARPAAEPLWEALTQALVEPFDGAEETPDPAWVTAVRLLLREPSLQAELIRGGARTRAELTAAIAARTGTDAERDLYPKLVASAALSAMQVSNEHYLSADPVVPFKSLFAEALRQLAAGLPEPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF01</accession>
    <name>A0A1E7NF01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000486.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39286">
        <property type="protein sequence ID" value="OEV39286"/>
        <property type="gene ID" value="HS99_0000790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10937" checksum="DDFD6A287FD9077B" modified="2017-01-18" version="1">MDPRAHPGPGGGDHRGRYDVVVVAPTVATTELLEAGADLAADGAVLLVYGGTRKGYTFPLEKLTSWRIGLDDFPRQVMDLAAELVDFPGKVVIDLAPAAPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF16</accession>
    <name>A0A1E7NF16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285219.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3543"/>
    <dbReference type="EnsemblBacteria" id="OEV39225">
        <property type="protein sequence ID" value="OEV39225"/>
        <property type="gene ID" value="HS99_0000400"/>
    </dbReference>
    <dbReference type="OMA" id="RDYWVLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045617">
        <property type="entry name" value="DUF6445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20043">
        <property type="entry name" value="DUF6445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="25222" checksum="3A9CAB057FA0F0B9" modified="2017-01-18" version="1">MPSQPIRSTALPVLPYRKPTRGRDYWVLDNVLPDPDAVRERVLARGDWTEGYPYRPETWPGLRTMPGLEPDELARVEAQVRKATGASRLWVQSTPGGGTLNHNCVQVVGAGESESRPHTDSRALCRYAAVLYLSPGAPKDAGTSFYRQQFPGGRLGGNLVNAPHNNLVEALGTRHVPADHFTEDVRVPNRYNQLLLYHANLIHSATNYYGTDLADRRMTAVFFWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF46</accession>
    <name>A0A1E7NF46_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0001050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367010.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3679"/>
    <dbReference type="EnsemblBacteria" id="OEV39331">
        <property type="protein sequence ID" value="OEV39331"/>
        <property type="gene ID" value="HS99_0001050"/>
    </dbReference>
    <dbReference type="OMA" id="CLAAQMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="601"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="845"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV39331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1151" mass="122418" checksum="131621EC150278AC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF63</accession>
    <name>A0A1E7NF63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550270.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3673"/>
    <dbReference type="EnsemblBacteria" id="OEV39327">
        <property type="protein sequence ID" value="OEV39327"/>
        <property type="gene ID" value="HS99_0001020"/>
    </dbReference>
    <dbReference type="OMA" id="YARMSIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="22171" checksum="F46D6C0C924C465C" modified="2017-01-18" version="1">MPATPAPQSPPPAPGRPPGRRLPGGPVLQDSVTEAIAAAFFEELAATGYARLSLEAVAKRAGAGKAAIYRRWASKLEMTVDLVSAVAVDASGPADTGSLRGDVLAFLAEVAHALNQPLAARIIPDLIAEGGRTPELAEALFTAVRDTRRGKATRLLDRAVDRGELPAAVDRELALDLLAGPLYWRLAVVHTPTAPDHLDRLADKLVAAFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFB2</accession>
    <name>A0A1E7NFB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat-shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288862.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000558.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1535"/>
    <dbReference type="EnsemblBacteria" id="OEV39362">
        <property type="protein sequence ID" value="OEV39362"/>
        <property type="gene ID" value="HS99_0001240"/>
    </dbReference>
    <dbReference type="OMA" id="PMPLDAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="16374" checksum="0746208CF2678BB2" modified="2017-01-18" version="1">MLMRTDPFRELDRLTQQFLNTTGTWSRPTPMPLDAYRTGDEYVICFDLPGVDPQAIDIDVERNMLTVKAERRPRQEGEGVKWELSERPLGVFSRQVMLSDTLDPEGITADYDSGVLTLRIPVAEKAKPRKIAIGHSDSRKQIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFB5</accession>
    <name>A0A1E7NFB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387468.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000939.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3670"/>
    <dbReference type="EnsemblBacteria" id="OEV39325">
        <property type="protein sequence ID" value="OEV39325"/>
        <property type="gene ID" value="HS99_0001010"/>
    </dbReference>
    <dbReference type="OMA" id="EWKFADQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042882">
        <property type="term" value="P:L-arabinose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026266">
        <property type="entry name" value="AraF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002816">
        <property type="entry name" value="AraF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199083" evidence="1">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="53"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="35779" checksum="9B33223C40533609" modified="2017-01-18" version="1">MHLSPRGRLAPLAALSLATAFGLTACSTGQTSSSGADASVAPVSGKVSITYLQKQGDQQYFVDEAAGAKAKAAELGADLKVVNLGNDANKTVGEVQAAIAQKSNGLIIVVPDPAVGPQVVRTARDAKAALLTSDDQVCATGPSPTECAAGDLVPRIGFSGQQMGQQVGQRAAEEFKKAGWNAADTRIISAWKQDVTVCGDRVKAARAAFDQAAPGVQDIDVATDNTPTGAQDKVAATITANAGVKHWVVWGCNDENVQGAVTALQNAGVSPDDIDGVGLGAYLACKDWTSGKPSGMKAALFINGKDVGALSVQTMYDKLKNGKDFPKEAFAPTKMVDAATWQSAGVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC8</accession>
    <name>A0A1E7NFC8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor_I42 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288898.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1517"/>
    <dbReference type="EnsemblBacteria" id="OEV39348">
        <property type="protein sequence ID" value="OEV39348"/>
        <property type="gene ID" value="HS99_0001145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I42" evidence="2">
        <location>
            <begin position="48"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15718" checksum="2E5F99F8415FBBA3" modified="2017-01-18" version="1">MNWRRILVGAFALLAVAGVVGAVVVHRMTTGKLDHGAVFTADSGELAVKPGELFSVEVSAHRVTGQVWSVAEPVPDPTAVQTVGDEYVKNFGLKDLVGATGSAGSGGRYYFVFRAGPNPGRATITLRNPNHTGGAGGSDQGERHYTVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG2</accession>
    <name>A0A1E7NFG2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39414">
        <property type="protein sequence ID" value="OEV39414"/>
        <property type="gene ID" value="HS99_0001560"/>
    </dbReference>
    <dbReference type="OMA" id="MDWSASA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="100" mass="10051" checksum="01BBC17196726D79" modified="2017-01-18" version="1">MSLAWSAARAMPKSISFTPSRTSMTLAGLMSRCAMPDACTARRWAAVSASSSHSASAGSGPCSRTASSTVSPGTYSVANHGRSGVPSLASTRGATPNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ3</accession>
    <name>A0A1E7NFJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481573.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000724.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7557"/>
    <dbReference type="EnsemblBacteria" id="OEV39444">
        <property type="protein sequence ID" value="OEV39444"/>
        <property type="gene ID" value="HS99_0001720"/>
    </dbReference>
    <dbReference type="OMA" id="IELACHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="35411" checksum="E2A17E4C0A4069CC" modified="2017-01-18" version="1">MTTRTALTAADLRLLAEAGGLAPSLHNSQPWHFRPTPDRSGLEVHADLARAVPVTDPDGRAMHISIGAAVFNLRVAAARLGREASLRLLPEGEGAQPCAVLDLSARARSSQPFGADLYPAIAGRHSSRHPFANRDVPEALVADLITAAREEGVTLTMLEEDGVRRVLALTSEAEARIAADATREAETHSWLRLEPSCDGIPLAALGSHDRDARIPMRGFTGHPPRHATPAARFEALPQIAILSTHFDKQADWLRTGQAMERVWLLATVHGLRASVLHQAIEIPDTRWRLRDPAEGPAHVQLVLRLGYGPPGVASPRCPLTEVLDLPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL2</accession>
    <name>A0A1E7NFL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39462">
        <property type="protein sequence ID" value="OEV39462"/>
        <property type="gene ID" value="HS99_0001830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16343" checksum="67207E241C2CB155" modified="2017-01-18" version="1">MSASSQSRPTRAFRGRHAGRILATSGKRWVPTPWLQQVKRASGVVSRVRAQVSRRSRWRIAAVRVAARSGATGFGASRSIANWAQTSPCSYQSSPAARSMAEMRTTTVAVRPRAGGFGSAARASRWRLSAWKRRWAISMACGPPNALDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL3</accession>
    <name>A0A1E7NFL3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000671.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5109"/>
    <dbReference type="EnsemblBacteria" id="OEV39464">
        <property type="protein sequence ID" value="OEV39464"/>
        <property type="gene ID" value="HS99_0001840"/>
    </dbReference>
    <dbReference type="OMA" id="DAVCFTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="278"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="278"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="39329" checksum="061AF17649564942" modified="2017-01-18" version="1">MATPTTSPGPLTGFTVGVTAARRREELVALLTRRGAQVVEAPVLRIMPLADDLALRQATERCLTAPLDYVVATTGVGWRGWMSAAEGWGGGTALAEACRGAVVLSRGPKATGAVRASGLGEGFSPGSEATDELLTWLLARPLDGCRIAIQEHGVRLDAFAAALRERGAEVISVPVYQWAPPDDMAPVRRLVDQTVRRQVHALTFTSAPAVAAFLATAEAEGLREPVLDALRGDVLPVCVGALCARPLADLGLPTVHPERGRLGSLVRLLAETLPTLGRREIPLSDAVLTLQGNAALVDGESHLLSPRGAAVLRALAERPGRVLSRAELLRVAWPDASADEHAVEAAVGRLRAALGPHAGIIRTVPKRGYRLAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY5</accession>
    <name>A0A1E7NFY5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39620">
        <property type="protein sequence ID" value="OEV39620"/>
        <property type="gene ID" value="HS99_0002810"/>
    </dbReference>
    <dbReference type="OMA" id="PPAEYVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="45500" checksum="B6CB02008E938053" modified="2017-01-18" version="1">MSGTEHTEPTAHVVVGYTPHEGFVAVQLSPPPAEYVWHDRRAEHQQERFGPGNRYQQWLAVDLGTGAVWFGDTDWRAPQEDSFPGLPGPRRAEVGDGALPSPAVLVHPLTHRGSDGQGACTWRFFTAEELHALAEGILPVVQRVIDSLHRVGPAGDLEWSAEAATAWSDLERACDHTSDATGAVVWAGPRASRVPGTRVEVADFLARNPELCDPSWSTATDAELDAYAAYEPVSGYGGVPGRMCAPAHVQIEDGYTFYGHRAALYAYRAAACGDRTPVEARIWLRTSDAGRTAWEAAKVVGASLADASDCVLAHLAETFRSAAGDDGVVLTGLPAYLWQERAEERAAVDETLAATGEELKRLEEMVTELRRVRNTVLTRVLSWTDGRDDEEIAGLAATSPTVVAEWRERLTADRGTRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB6</accession>
    <name>A0A1E7NGB6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550424.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2838"/>
    <dbReference type="EnsemblBacteria" id="OEV39688">
        <property type="protein sequence ID" value="OEV39688"/>
        <property type="gene ID" value="HS99_0003220"/>
    </dbReference>
    <dbReference type="OMA" id="GHRAPIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199119" evidence="3">
        <location>
            <begin position="45"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="917" mass="97783" checksum="F39603DAAA8F1093" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC1</accession>
    <name>A0A1E7NGC1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550459.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2883"/>
    <dbReference type="EnsemblBacteria" id="OEV39724">
        <property type="protein sequence ID" value="OEV39724"/>
        <property type="gene ID" value="HS99_0003440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199130" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="100" mass="9721" checksum="ECFACA0443AADDFE" modified="2017-01-18" version="1">MATSRNLAAAAVCAALALGAVTGCSSSGGFGDPSAKQSSGANQNLTALIATSGEAETAAVKAATADWAILAALQRNGEPIAANCCATSRCPRCGPSCSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG9</accession>
    <name>A0A1E7NGG9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2884"/>
    <dbReference type="EnsemblBacteria" id="OEV39725">
        <property type="protein sequence ID" value="OEV39725"/>
        <property type="gene ID" value="HS99_0003445"/>
    </dbReference>
    <dbReference type="OMA" id="HERIAWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37077" checksum="AD576EC9738B9A67" modified="2017-01-18" version="1">MHPHSSPRPRTGPAVTLEMVAARAGVGRQTVSNAINSPELLRPQTLERVRHAIDELGYRPHRAAQALKTRASRLIGYGIRSSSTRVPTPVLDQFLHSLSEAADRAGYRVVLFAVAPGDDELTSYQQLLDEHGADGFVLSGTDRGDRRQGWLHERGVPFVAFGRTWSGKDVGDWVDVDGAAGTSAAVRHLAGLGHRRIGFLGWPKGSGVGDDRARGWQSAMRELGLPTRGRRVASPDDPEQATEAAEKLLATGATAVVAASDTLALGWYRALRRAGRGPGPEAAVIGFDDSPIAPLLFPSLSSLAQPLDAVGRTCMRLLLDRLGDRDRPTEHILLEPELVLRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ4</accession>
    <name>A0A1E7NGJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6705"/>
    <dbReference type="EnsemblBacteria" id="OEV39583">
        <property type="protein sequence ID" value="OEV39583"/>
        <property type="gene ID" value="HS99_0002585"/>
    </dbReference>
    <dbReference type="OMA" id="DPNVLRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="42565" checksum="A1399BD019551DA2" modified="2017-01-18" version="1">MATLETAPSVRPALPAHRDANVLRWLTAYTASLVGDTVYFLALGWSAQKTVGPTELGLVMAAGALPRAVLMLGGGVVADRLDPRRVILGSDALRCLLILSIAAAVALTTPALWLLIAVALVFGAVDALFVPAVGALPPRLTSPDQLARVTGLRSLAMRLGQIAGPPIGGLAMALGGPAVAFTVAGGLFALSLPLLLSVRIRPLEPHEDRAAPGGSGTARAELRDGLRYLRRHRLLGPLVLVGAVCELGLIGTLNVGMVLLNAERGWGPSGLGLIVACFGAGAAAGAALLAVAGWLPRAGLTMAVTLLLGSLGAAAMGSLPALWSAAVLAAFVGLSAGVFGSLDGALVQTTADPAYLGRVTSVVMLTMVGVAPLSYPLVGAAIGAWGAAPVFLGCGGLSCLGAIYALTSRPVRQAELPRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGN1</accession>
    <name>A0A1E7NGN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0002825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2759"/>
    <dbReference type="EnsemblBacteria" id="OEV39623">
        <property type="protein sequence ID" value="OEV39623"/>
        <property type="gene ID" value="HS99_0002825"/>
    </dbReference>
    <dbReference type="OMA" id="QVPYAGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="9">
        <location>
            <begin position="32"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="479" mass="51163" checksum="22CF5A1F2A7416C4" modified="2017-01-18" version="1">MSEQFLKDEKRPSTRHVDAGDTGYSKSLKPRHVNMIAIGGAIGTGLFLGAGGRLADAGPSLFVAYAVCGVFAFLVVRALGELVLYRPSSGAFVSYAREFLGEKGAYTAGWMYFLNWATTGIADITAVATYAHYWHLFSDVPQWVIALVALAVVLTVNLISVRIFGELEFWFAIVKVSALVVFMGIAIVLLVTRHPVDGTVPGPSLVTDNGGIFPNGLLPMLLIIQGVVFAYASVELVGVTAGETENPEKIMPKAINSIMWRVGLFYVGSVLLLSMLLPWNRYTAGQSPFVTVLSHIGVPAAGSVMNLVVLTAAMSSLNSGLYSTGRILRSMAVNGSAPRFTARMSRSQVPYGGILLTSGMCVLGVVLNYVVPADAFEIVLNLAAIGILATWGMIMICHLFFWRKTRAGELTRPAYRLPGSPWTELVTLAFLVTVLVLMYADGGAGRTTVLCVPLIAAVLVAGWYAIRGRAGRAAAGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV39</accession>
    <name>A0A1E7MV39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6872"/>
    <dbReference type="EnsemblBacteria" id="OEV32296">
        <property type="protein sequence ID" value="OEV32296"/>
        <property type="gene ID" value="HS99_0016425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="9839" checksum="4527F7FEA3AE7C4E" modified="2017-01-18" version="1">MRLVGPVAEGVGEQALPGDLGEQFGADLVTAVDQSGQRGDAFPGEATDAPIVLGITTGSLLGSRLSGRLSVGTIEAVYTTVVLASGLSFLLGALGVINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV67</accession>
    <name>A0A1E7MV67_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6917"/>
    <dbReference type="EnsemblBacteria" id="OEV32330">
        <property type="protein sequence ID" value="OEV32330"/>
        <property type="gene ID" value="HS99_0016640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9626" checksum="A10A8F444085C65D" modified="2017-01-18" version="1">MARPLSRERFAARPHDLRGRHRDTNQSHLRPHSGGCTPLELRRRTPELVLDHCVTGTQQQAAADAPALKCEVLRAMPDAVDHGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG5</accession>
    <name>A0A1E7MVG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0040285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000098">
        <property type="protein sequence ID" value="OEV32253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7114"/>
    <dbReference type="EnsemblBacteria" id="OEV32253">
        <property type="protein sequence ID" value="OEV32253"/>
        <property type="gene ID" value="HS99_0040285"/>
    </dbReference>
    <dbReference type="OMA" id="IVERMYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16006" checksum="6B2E788956DD102A" modified="2017-01-18" version="1">MPGAGTVPVPGPQGAGPHAGSASPRGRAPHTEFEFELPLGYVDDEGTVHRHGAMRLATARDELMPQIDLRVKENPAYLGVVLLSHVITRLGDVTDVHAGIVERMYATDVAFLQDLYQRINSEGHTRAAVTCPHCDGAFEVDLAGGRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW56</accession>
    <name>A0A1E7MW56_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3148"/>
    <dbReference type="EnsemblBacteria" id="OEV32660">
        <property type="protein sequence ID" value="OEV32660"/>
        <property type="gene ID" value="HS99_0015425"/>
    </dbReference>
    <dbReference type="OMA" id="EWDTDVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="30214" checksum="197F10FF5C77ADA3" modified="2017-01-18" version="1">MTSPASATRPRAGTKTTLGVGLGWRSEIDTVVERQPGLDWVEVVAENICADHLPTSLTVLRRRGVTVVPHGVGLGLGGAGLPDPERLDRLAATAVALDSPLVTEHLAFVRAGGLEAGHLLPVPRTRDSLRVIAENVRIAQDQLPVPLALENIAAQLAWPDDEFTEGEFLAELVARTGVRLLIDVANLHTNRVNLGTDPAAELDRLPLEALAYVHVAGGTLVDGVWHDTHAHPVTEPVLEVLAELCARVAPPGVLLERDAAFPPPSELAGELDAIRRVLEGSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA1</accession>
    <name>A0A1E7MWA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290243.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7873"/>
    <dbReference type="EnsemblBacteria" id="ARF78261">
        <property type="protein sequence ID" value="ARF78261"/>
        <property type="gene ID" value="B6264_04420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32701">
        <property type="protein sequence ID" value="OEV32701"/>
        <property type="gene ID" value="HS99_0015665"/>
    </dbReference>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="32722" checksum="FDC9FF8B95CF550C" modified="2017-01-18" version="1">MNPVPAVEIAGLVKRYGDKAAVDGLDLTIARGAITAVLGPNGAGKTTTIETCEGYRRPDAGTVRVLGLDPATQSAALRPRIGVMLQSGGVYAGARAVEMLRHTAKLHAHPLDVDALVERLGLGSCGRTTYRRLSGGQQQRLALAMAVVGRPELVFLDEPTAGLDPQARRATWELVRDLRRDGVTVVVTTHHMDEAEQLADHVAVVDRGKVIANGTTEELCRGGAEDALRFDGPPGLDLGPLLKELPAGATAAETAPGQYRVAAPVDPSRLLATVTGWCAASGILPERLSVQRRSLEDVFLDLTGRELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF7</accession>
    <name>A0A1E7MWF7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557625.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7808"/>
    <dbReference type="EnsemblBacteria" id="ARF78201">
        <property type="protein sequence ID" value="ARF78201"/>
        <property type="gene ID" value="B6264_04080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32754">
        <property type="protein sequence ID" value="OEV32754"/>
        <property type="gene ID" value="HS99_0016000"/>
    </dbReference>
    <dbReference type="OMA" id="YKHMVGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="40879" checksum="A3C59C8D2BA2B0EB" modified="2017-01-18" version="1">MPPIGLHRAIVIGGGIGGLTAALALHRQGIPVTVHERAASLEPVGAGLALAPNALRALDRLGVGPRLRALAAPHPAIGVRHPSGRWLARTSTAALEAYFGDPVAAVARAEVIAALVDALPEGTVRTGSPATVVDPGDDRQPAVVRTTDGDRPAALVVAADGIRSATRGLLFPEHPGPRYSGFTTWRVIVTPDRRPATAGEIWGPGRLVGIVPLADGRVYLYAATLAPAGARAASEHAELQRLFGDWCSPVPQLFALADPDRVLRNDIWDLSDPLPAHHHGRVALLGDAAHAMSPFLGQGACQAIEDAVVLASLLTPTADPVAALPAYTAARLPRTTAVVTASRRTGALIALHTPAATLLRTTALTLAGLLPTRTLLRRSAPIYDWQPPAPAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS6</accession>
    <name>A0A1E7MWS6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bipA</name>
        <name evidence="2" type="ORF">HS99_0039655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287360.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000623.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene440"/>
    <dbReference type="EnsemblBacteria" id="ARF78869">
        <property type="protein sequence ID" value="ARF78869"/>
        <property type="gene ID" value="B6264_08015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32892">
        <property type="protein sequence ID" value="OEV32892"/>
        <property type="gene ID" value="HS99_0039655"/>
    </dbReference>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="634" mass="69264" checksum="BEC6B45339C11ACC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX13</accession>
    <name>A0A1E7MX13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3813"/>
    <dbReference type="EnsemblBacteria" id="OEV32783">
        <property type="protein sequence ID" value="OEV32783"/>
        <property type="gene ID" value="HS99_0015065"/>
    </dbReference>
    <dbReference type="OMA" id="RWVNAVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="13257" checksum="215086723277C5C4" modified="2017-01-18" version="1">MSASQSGDKLAVLQQLAVFGAQLGMQWVGVGDMPGNNWSGGSRDDLNRLGSWLGLMSQSHADLGPEQAGSRGDLLTARRYGERIARLAQRWVNAVPYGTPRMTEHEARALSASLREAEAAPAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX54</accession>
    <name>A0A1E7MX54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552473.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5704"/>
    <dbReference type="EnsemblBacteria" id="ARF81415">
        <property type="protein sequence ID" value="ARF81415"/>
        <property type="gene ID" value="B6264_23110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32999">
        <property type="protein sequence ID" value="OEV32999"/>
        <property type="gene ID" value="HS99_0014080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="16795" checksum="892685A18E1B970D" modified="2017-01-18" version="1">MTLALLGLHLAVTGVLLPRLLAGSARLQARPALGAALWLALMASFTVALVLAGHHAVEPAAHEPAGLLGLLGPIGLLPHLETTGPVLPHTHDWWLLAAAGAVLAALATSGGTPGGTLAVASTGVLARVRRLARPGSGRRRRPVWWLGLLTLPALPYLLACAPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA1</accession>
    <name>A0A1E7MXA1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5628"/>
    <dbReference type="EnsemblBacteria" id="ARF81478">
        <property type="protein sequence ID" value="ARF81478"/>
        <property type="gene ID" value="B6264_23485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33062">
        <property type="protein sequence ID" value="OEV33062"/>
        <property type="gene ID" value="HS99_0014455"/>
    </dbReference>
    <dbReference type="OMA" id="IRHYLFV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36680" checksum="1ABE5EC55C94A6E1" modified="2017-01-18" version="1">MPSPLISVVLPAYDQHGQLADCLDSLLAQSLANVEVIVVADRSPETAAGLADSFAARHARVSVLHLNAAVGVGVSRNAGAARASGDYLLFLDADHLLPRDALQALADRLQQTGPVDVLLFGHSRRHNDRDWPGGAETLLAEAGPEAFAPFDRPELFGAPPLIWDRLIRRGHWQELGLTFPDGRYEEVPVVHAALLGARKAAVLARECVQLRRRETVHPAGGPGSSVFDLFDQYERSFALLEDQPHLYAVRDALFVRMIRHYLFVFDLAGCVTRAERPQFFHRAAEHHRRFMPPGHRKPGGRLGIKFSLLASGAYPAFEVAKLSHIARGTLTGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXG5</accession>
    <name>A0A1E7MXG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2685"/>
    <dbReference type="EnsemblBacteria" id="OEV33126">
        <property type="protein sequence ID" value="OEV33126"/>
        <property type="gene ID" value="HS99_0014850"/>
    </dbReference>
    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="30713" checksum="7EB7B86F53A0AB19" modified="2017-01-18" version="1">MPLTPLFAAVDIGGTKIAGALVDGDGRLRHRLQLPTPATEPGAAVLAVVHKVLDQLAGTPDWSAVTAVGIGSAGPVDLADGTVSPVNIPGWRGFPLVAEVTAHPAVAARYLPVRLAGDGVAMAAAEHWQGAARGADNALCLVVSTGVGAGLVLDGAVRPGPSGNAGHLGHITVDLDGEPCPCGSRGCLEGLASGTAIARRALADGWRPPGEDRTARAVAVAAAGGDPVALASFDRAAQALAAGIAATAALVDLHRVVVGGGVAAAGEVLFAPLARHLDCYAALSYVRGLDVRRAELGTDAGLIGAAALCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK0</accession>
    <name>A0A1E7MXK0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3434"/>
    <dbReference type="EnsemblBacteria" id="OEV33168">
        <property type="protein sequence ID" value="OEV33168"/>
        <property type="gene ID" value="HS99_0014640"/>
    </dbReference>
    <dbReference type="OMA" id="YAWGWLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14150" checksum="C3EED92F9CB8E5BF" modified="2017-01-18" version="1">MPIDGQRRRLPLTGLPRPVAHARTFTAAALAHWSWPDPNRASDIVLLVTELVANAAVHADGPLELVLHASAARLRIEVSDRSPALPAPRRPRHPGLPGGHGLFIVQQTSDRWGTAPHRHGKTVWAEFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXR8</accession>
    <name>A0A1E7MXR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000073">
        <property type="protein sequence ID" value="OEV33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557708.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000400.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7584"/>
    <dbReference type="EnsemblBacteria" id="ARF81767">
        <property type="protein sequence ID" value="ARF81767"/>
        <property type="gene ID" value="B6264_25285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33204">
        <property type="protein sequence ID" value="OEV33204"/>
        <property type="gene ID" value="HS99_0039280"/>
    </dbReference>
    <dbReference type="OMA" id="FRRCESM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="43711" checksum="ED6254978FEFC5B0" modified="2017-01-18" version="1">MTSTGPRVVDFPLRRPGEAFPPPHYQDYRGERGLVVCHLPNGNRVWLVTRHEDVRAVLTDRRISSNPDHPGFPNISQTMGVPRQEQIPGWFVGLDSPEHDRFRKALIPEFTVRRVRELRPAVEQTVDRCIDGLLAAGTEADLVADFALPVPSLVISALLGVPPADRDFFESRTRTLVAIRSSTDQQRDTASRELLRYINRLVAIKQKWPGDDLISRLLATGAIDPREMSGVLMLLLIAGHETTANNIALGVVTLLAHPEWIGDPRVVEETLRFHSVADLVSLRVAVEDVEIAGQQVRAGEGIVALVAAANHDERAFACPHAFDPARTERHHVAFGYGVHQCLGQNLVRVEMEIAYRRLFERIPGLRLAVPAEELPYKYDGVLCGLHALPVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX8</accession>
    <name>A0A1E7MXX8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386302.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3433"/>
    <dbReference type="EnsemblBacteria" id="OEV33093">
        <property type="protein sequence ID" value="OEV33093"/>
        <property type="gene ID" value="HS99_0014645"/>
    </dbReference>
    <dbReference type="OMA" id="DGYHRQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="16871" checksum="6D6BC6C3228E7D89" modified="2017-01-18" version="1">MTATPDPAATQPPGPGPTVRLSLTPEGATRGRLDGAWWPRSHDLLRELPPLAAALDPTWGKVTRVTVNPTHWPVIPRRVQVAGHVIHVGWFEQEQDADEVIVCSFTPLRLELLVIPPEAEASAAEWLMTAASDPANTRTGTDLLTAAGAPTADPRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ7</accession>
    <name>A0A1E7MXZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283446.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33113">
        <property type="protein sequence ID" value="OEV33113"/>
        <property type="gene ID" value="HS99_0014780"/>
    </dbReference>
    <dbReference type="OMA" id="WPRNFLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29996" checksum="51D18A4EB1A549C0" modified="2017-01-18" version="1">MNQDPIPPTVRRTYGAEDLSKAASFGGGFINFGDWQGIDLTALTPEDRVRSQEQLYRRVLRAFPEPRERLRLAEVGCGRGLGAALALREFRFASVTGVDIHPDQVERARAVNARAQATYPDRLAYTIGSADELPFHDASLDGVYSVEAAQHFRRLSGFAREAARVLRPGGRLVVTTFFATPGDEITERLKLLLASFADGLDVPHTLNGFTTDLTNASFTDVTTETIGPDVWPGLDRYLADTVPTDHWTRNFLPAWRHGLLDYHLITATRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY88</accession>
    <name>A0A1E7MY88_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ACP S-malonyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287572.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3975"/>
    <dbReference type="EnsemblBacteria" id="ARF80514">
        <property type="protein sequence ID" value="ARF80514"/>
        <property type="gene ID" value="B6264_17800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33410">
        <property type="protein sequence ID" value="OEV33410"/>
        <property type="gene ID" value="HS99_0012575"/>
    </dbReference>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="316" mass="32136" checksum="4A898E769DE66ABB" modified="2017-01-18" version="1">MLVIVAPGQGAQSPGFLSSWLELDGVADRLRGWSEVAGLDLVHAGTEASAEEIKDTAVAQPLLVAAGLVTARELFPDEADARKLVGAVAGHSVGEITAAAGAGVLSAHDALAFVRERGRAMAEAAAVTETGMTAVLGGDAEEVAKKLAEHGLTAANNNGGGQIVAAGTLAQLEALKADPPAGAKLIALKVAGAFHTEHMAPGVERLAALAPSLTVADPQVRYVSNKDGGVVDSGAEVLARLVSQVSNPVRWDLCMETLGRLGATAVIELSPAGTLTALLKRNLKGVATLALKTPADLDKARELVAEHGGQDQEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY97</accession>
    <name>A0A1E7MY97_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287579.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3979"/>
    <dbReference type="EnsemblBacteria" id="ARF80510">
        <property type="protein sequence ID" value="ARF80510"/>
        <property type="gene ID" value="B6264_17780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33406">
        <property type="protein sequence ID" value="OEV33406"/>
        <property type="gene ID" value="HS99_0012555"/>
    </dbReference>
    <dbReference type="OMA" id="ALCPHIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="18083" checksum="9E4231F2BCFE4651" modified="2017-01-18" version="1">MTTRGVLYIHSAPRALCPHVEWAVAGVLGVRVGLDWIRQPAAPGHWRAELSWQGEPGTASKLASALRGWQLMRYEVTSEPCATAEGERYSSTPSLGIFHAVTGIHGDILIPEDRLRAVLLRARSEGADLEAEIARLLGKPWDDELEPFRYAGEGAPVRWLHQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYH6</accession>
    <name>A0A1E7MYH6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000528.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5156"/>
    <dbReference type="EnsemblBacteria" id="ARF80592">
        <property type="protein sequence ID" value="ARF80592"/>
        <property type="gene ID" value="B6264_18265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33486">
        <property type="protein sequence ID" value="OEV33486"/>
        <property type="gene ID" value="HS99_0013045"/>
    </dbReference>
    <dbReference type="OMA" id="LAYGMEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="318"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="533" mass="55722" checksum="17B0D71B000DF7DB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI5</accession>
    <name>A0A1E7MYI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5154"/>
    <dbReference type="EnsemblBacteria" id="OEV33484">
        <property type="protein sequence ID" value="OEV33484"/>
        <property type="gene ID" value="HS99_0013035"/>
    </dbReference>
    <dbReference type="OMA" id="VEPAYEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198647" evidence="2">
        <location>
            <begin position="24"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="691"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="829"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="946" mass="97626" checksum="09C7302757F29E7C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU3</accession>
    <name>A0A1E7MYU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386702.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6597"/>
    <dbReference type="EnsemblBacteria" id="OEV33596">
        <property type="protein sequence ID" value="OEV33596"/>
        <property type="gene ID" value="HS99_0012865"/>
    </dbReference>
    <dbReference type="OMA" id="PEFAMWC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="33095" checksum="B4ED0046C2C8819C" modified="2017-01-18" version="1">MRSDAQSTPSGTGEGGRLLAVSDLHISYQENRDLVEKLKPTHPDDWLLVAGDVAELTTSIEWALGLLAERFARVVWAPGNHELWTHPEDPVQLRGVARYDHLVELCRALGVVTPEDPYPLWQGAGGPVRIAPLFLLYDYSFRAPGTATKEESLAAAYESGIVCADERMLHPDPFPDLDSWCRERVRLTEQRLAACDPDVPLVLVNHYPLVRHPTEVLWYPEFAQWCGTELTADWHRRFNTAAMIYGHLHIPRKTSYDGVPFEEVSLGYPREWRKRGLPDPLLREVFPQAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ13</accession>
    <name>A0A1E7MZ13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557092.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000291.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4293"/>
    <dbReference type="EnsemblBacteria" id="ARF80352">
        <property type="protein sequence ID" value="ARF80352"/>
        <property type="gene ID" value="B6264_16820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33690">
        <property type="protein sequence ID" value="OEV33690"/>
        <property type="gene ID" value="HS99_0038350"/>
    </dbReference>
    <dbReference type="OMA" id="WPELEYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="50526" checksum="DD64822602021AC3" modified="2017-01-18" version="1">MTSAAATGYCRVTVVAPDRRIDVALPEDVALADVYPEVLRLANQSQPDGTPTGFHLVRRDGTVLDSSLSLAAQQVRDGDLLALRPFAESLPPAVYDDVADAIASAVEADRRFWTVDLMRGFGLIGTGVLLTLLGFALWFSDLRHDMHSLPGVLAGVTAVVLTALAGVRARVYGDAPAAVALGLGALPHALIAGSGIIAVAHKWDGPGRLQFLTGCVTVLVIAVLLAGLLPTMDAVFVAAAFVATAGALATFAAVLMPDTPAGNIAAVTGVAAVAAVGFLPSLSARFARLPVGFSAPGQTRTRSRDYDEEAERAEAVQYERIAHQARRGHEVLVGLVGGCAAVVVGACAVLSFTDRTFPELLALALGIATMLRARLFRYTAQVLSLTAAGLLGLCLLIVGLSLHTPQFILRTAGAGTDLDLRTIWLAASIAFGAALLTAIALVVPRLGVSPFWGRILDLVDSLTLISLVPLALAVLNIYRLVRGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG5</accession>
    <name>A0A1E7MZG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4312"/>
    <dbReference type="EnsemblBacteria" id="OEV33828">
        <property type="protein sequence ID" value="OEV33828"/>
        <property type="gene ID" value="HS99_0037445"/>
    </dbReference>
    <dbReference type="OMA" id="TCVGCRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9408" checksum="38AD3A1BEE883D16" modified="2017-01-18" version="1">MGCRKRAAKHELLRVTAVEGVCVPDPRGALPGRGAHLHLDLACLDLAVRRRAFPRAFRLQGALDTERLRGFIEERVGGAPSADRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ5</accession>
    <name>A0A1E7MZQ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385913.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1838"/>
    <dbReference type="EnsemblBacteria" id="ARF77748">
        <property type="protein sequence ID" value="ARF77748"/>
        <property type="gene ID" value="B6264_01340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33905">
        <property type="protein sequence ID" value="OEV33905"/>
        <property type="gene ID" value="HS99_0010500"/>
    </dbReference>
    <dbReference type="OMA" id="HAGDQPK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="36305" checksum="A82A9CF4AC0B9928" modified="2017-01-18" version="1">MSELATAVAATLRAAEPYATAVTVAVARGDREQVRCHGRLGLAPVAPPCTPETVFELGSVTKTFTALLLAQMAARGELALDDRLEHHLPPNWRPAKVRSADPVRLLHLATHTSGLPRLPPGLLASAAPAWFTNPYATYGEDQLRRGLARTTVRGRPGSRYCYSNYGVGLLGRLLAESGGLPYGELLAERVCGPLGLRSTTCAPDAPGLAVGYRRGRPVPPWRIPGLPGAGAVRSSGADLLRYLRAHAVGTGGELGAALRNVQRLRLRLPHSTDRLGLVWMHRRSGVRDLYFHSGGTRGFTSFAGFSPEGPTAVAVLANTAPAPDGRLVRAGYEVLRAAAAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N019</accession>
    <name>A0A1E7N019_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidoglycan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280110.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2286"/>
    <dbReference type="EnsemblBacteria" id="ARF77896">
        <property type="protein sequence ID" value="ARF77896"/>
        <property type="gene ID" value="B6264_02225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34038">
        <property type="protein sequence ID" value="OEV34038"/>
        <property type="gene ID" value="HS99_0011375"/>
    </dbReference>
    <dbReference type="OMA" id="ADENWAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="30871" checksum="9E3F5569607EA69B" modified="2017-01-18" version="1">MKRIPALVAAMFAALLAAVLVAPAAQAASWPIVRNGDRGDNVTTVQYLLSARGFATGVDGAFGPGTEDKVKSFQSASGLTPVDGVVGSDTWSKLIVTVRSGDNGDAVKALQVQLNAHGAGLAVDGAFGPGTDSKVRNFQQSAGLNPVDGIVGPATWGALLGGGGSTGGSGGSGGDTLSQSQAASMLSSAGITWSSSGNCSDRNSSSCTSFDGIRRATVDGAINLKHAVGSCPLNITGGTETGHASGTYSHGTGYKMDFAMMSCLTNYIHGTFTHSGTRGDGADLWTAPSGNIYANEGSHWDVTFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N046</accession>
    <name>A0A1E7N046_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280050.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2320"/>
    <dbReference type="EnsemblBacteria" id="ARF77925">
        <property type="protein sequence ID" value="ARF77925"/>
        <property type="gene ID" value="B6264_02400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34067">
        <property type="protein sequence ID" value="OEV34067"/>
        <property type="gene ID" value="HS99_0011550"/>
    </dbReference>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32219" checksum="D9F328298FDDBAFB" modified="2017-01-18" version="1">MSRRTAVRRVAVLTNPAAGTGHAEPAAHRAVARLRALGVEVEPQAGRSADDTVRLAREAAAGRVDAVVVVGGDGMINLALQALADGTVPLGLVPAGTGNDHAREYGLPLGDPEAAADVIAAGRTRSVDLGRITGPDGAVRWYGSVLATGFDSLVSDRANRLRWPRGRMRYNLAILAEFANLRPLPFRITLADGTVIERDLTLAAVGNTRSYGGGMLICPSARPDDGLLDLTLVDAMPRLRIARFFPTLFKGTHIDHPEVTTLRTESLRMESPGITAYADGEFINTLPVEVTLRREALRLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0B1</accession>
    <name>A0A1E7N0B1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0011965</name>
        <name evidence="5" type="ORF">HS99_0011970</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000153_gene4676"/>
    <dbReference type="EnsemblBacteria" id="ARF78002">
        <property type="protein sequence ID" value="ARF78002"/>
        <property type="gene ID" value="B6264_02825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34137">
        <property type="protein sequence ID" value="OEV34137"/>
        <property type="gene ID" value="HS99_0011965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34138">
        <property type="protein sequence ID" value="OEV34138"/>
        <property type="gene ID" value="HS99_0011970"/>
    </dbReference>
    <dbReference type="OMA" id="VILWINC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014268667" description="SGNH_hydro domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="3">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="54031" checksum="59FA39F96EA0F38A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N102</accession>
    <name>A0A1E7N102_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1863"/>
    <dbReference type="EnsemblBacteria" id="OEV34143">
        <property type="protein sequence ID" value="OEV34143"/>
        <property type="gene ID" value="HS99_0010625"/>
    </dbReference>
    <dbReference type="OMA" id="NISHHDF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="294"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="44043" checksum="C11CE487693EC061" modified="2017-01-18" version="1">MNSAVKSTLDSTANSTLGNPVHRRVASLAADELPSYVHDLAALREHAATVRAALPERVELYYAAKANPEAPLLTALSDAVDGYEVSSGGELAHVRAAVPDAPLAFGGPGKTPAEIAAAVDAGVHRWHVESEQELHRLAAVLAERPGAAVDVLLRVNLPVVTDALDAVPLAMGGRPTPFGLDPDRAEECVRLLTDGGPLGRQLRLRGVHAHLASGLAAAEQLAVAQQIVTWSAELAERTGFPLTEVNIGGGMAVDYDDPARRFDWTAFGEGLAELLDAHPGLVLRIEPGRALTAYCGWYATEVLDVKRSHGEDFVVVRGGTHHLRTPATRGHSQPFTVLPVDAWPHPWARPAVGSGRATLAGQLCTPKDVLARAATGAAGLRAGDRVLFAMAGAYAWNISHHEFLMHPRPGFHYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N116</accession>
    <name>A0A1E7N116_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FUSC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835543.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3925"/>
    <dbReference type="EnsemblBacteria" id="OEV34390">
        <property type="protein sequence ID" value="OEV34390"/>
        <property type="gene ID" value="HS99_0036235"/>
    </dbReference>
    <dbReference type="OMA" id="MRLWVTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032692">
        <property type="entry name" value="YccS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12805">
        <property type="entry name" value="FUSC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="FUSC-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="640" mass="67403" checksum="03A9FF4C694E6348" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N134</accession>
    <name>A0A1E7N134_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290849.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000305.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7196"/>
    <dbReference type="EnsemblBacteria" id="ARF79215">
        <property type="protein sequence ID" value="ARF79215"/>
        <property type="gene ID" value="B6264_10060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34394">
        <property type="protein sequence ID" value="OEV34394"/>
        <property type="gene ID" value="HS99_0035880"/>
    </dbReference>
    <dbReference type="OMA" id="GWMAFDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="51038" checksum="1FD5F5DC8112524E" modified="2017-01-18" version="1">MTVSPRGPNERLGTLLTLAQISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGPVPHLIATAIGGKLGRPVPLEEIGLGDTDPAPELGLAFPRDVADAVRSATDLFRVDLDLRRGPGGGRWSDSLAGTFSVAAYATPVSRWLINPADGSVAREVPRSPSENSSYRVGHSDAVKLREAAQEARRWDSKYGGGDWRSSMVPECLRVEAAPLLLASYSDAVGRALFGATAELTRLAGWMAFDTGQHEAAQRYYIQALRLARAAADVPLGGYVLASMSLQAGYRGFAEEAVDLAQAALERNRSLATARTMSFFHLVEARAQAKARNAAACATALGAAESALERARAGDPDPAWIDFYAYDRLAADAAECFRDLGVPSKVRQFTREALAKPTEGFVRSHGLRLVVSAMAEAEAGNLDAAVAAGERAVEVAGRISSQRSREYVVEMLRRLEPFQGERRVRELTERARAVIVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N136</accession>
    <name>A0A1E7N136_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0035965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1426"/>
    <dbReference type="EnsemblBacteria" id="OEV34408">
        <property type="protein sequence ID" value="OEV34408"/>
        <property type="gene ID" value="HS99_0035965"/>
    </dbReference>
    <dbReference type="OMA" id="WPGQQWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="44177" checksum="34A3E3325550AA55" modified="2017-01-18" version="1">MLAVLALVAAARYRAVSVTQRGRADRLEGELASLQEQLTSELSRRGADLAAVQQEQELTASTQRAFLSVARRILVMAHDQQALLDEMERTHDDPALLEGLLKADHAAAQQARLAQTLAVLCGARAGRHWPEPVSLEDVVRGAQSRILPFQRVVVRSRIETAVVGAAAEALIHAVAELLDNATRYSPPSTQVFVTLMPVHNGAVIEIDDGGVGMPEQAVAKAAAALAGGSSLEVSRLGEVPQLGLAAVGRLAESYGFRVTLSSAPSPYGGVRVVVLLPNALLTEPLPPTVPGLGLGLDGDDPAFTPGPAFRPGPAFTPGPQPTAGTAHPGAAHPGAGHPDAGHPLVEPPPAGRPAATGDAPPPLPRRSHRRDRGNRPAQHAAPPPPPEPPHRSARDAQTFMTMFQAGTANGRSAARAQGRPPGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N147</accession>
    <name>A0A1E7N147_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555343.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1411"/>
    <dbReference type="EnsemblBacteria" id="ARF79238">
        <property type="protein sequence ID" value="ARF79238"/>
        <property type="gene ID" value="B6264_10215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34420">
        <property type="protein sequence ID" value="OEV34420"/>
        <property type="gene ID" value="HS99_0036035"/>
    </dbReference>
    <dbReference type="OMA" id="AGKWANK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046129">
        <property type="entry name" value="DUF6126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19621">
        <property type="entry name" value="DUF6126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7668" checksum="3B5F161B398D1FA7" modified="2017-01-18" version="1">MADPTTATVPTATLPTVAVPTGAADTATGPKTMDAGKWANKRVYLRLVIYTAGIHVFAGFIMLLFELGNRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I7</accession>
    <name>A0A1E7N1I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552833.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000333.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5591"/>
    <dbReference type="EnsemblBacteria" id="ARF79328">
        <property type="protein sequence ID" value="ARF79328"/>
        <property type="gene ID" value="B6264_10710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34541">
        <property type="protein sequence ID" value="OEV34541"/>
        <property type="gene ID" value="HS99_0035190"/>
    </dbReference>
    <dbReference type="OMA" id="PADLMWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31952" checksum="F8A755ED2F0067AF" modified="2017-01-18" version="1">MSAQQHGHQHHGHQHHGHGHVPAADLDWDALAAHLELEADLRAEAVTEAGRWLSGLAGDGAVRRVLDVGAGPGVIAGLLAEVFPAAEVVAVDQSAALLERARARAGGRLGTQQADLPAEFDKLGEADLIWSGNAIHHLGDQQAALTALAGRLRPGGLLAVAESGLPARYLPRDFGLGRPGFQARLDAVHEDGFAAMRAELPGTTEEIEDWPAMLRRAGLVPSGTRTFLVDHPAPLARPVREYLRTQLARRHDQLAEVLDPEDRATLEALIEQDAPTGVLHRPDAFYLSAMTVHTARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N276</accession>
    <name>A0A1E7N276_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3235"/>
    <dbReference type="EnsemblBacteria" id="ARF81840">
        <property type="protein sequence ID" value="ARF81840"/>
        <property type="gene ID" value="B6264_25740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34798">
        <property type="protein sequence ID" value="OEV34798"/>
        <property type="gene ID" value="HS99_0010000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="27580" checksum="0E17DA2E2D133520" modified="2017-01-18" version="1">MTVHGLDHGPQCVPVGQMLRVVALLGRAFSAVEMMAVLQRPATELLTPVAEAIAAGVLEERGDLLAFRHDLIRRVVVQSYSQAVRTALYRQIGVALAAMNAPVERVAEHLLEAAQLGESDQLPPRRPCMTTTDHSHALHHNFVVALLNDLFGIQARGGCSCAGPYGHRLLGIGEEHSGALRDEVVMRGREGIKPGWTRVSFPYFMSDTVRDFIIEAVDLIATEGHRLLPDYRFTPGSGLWRHRLARRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N295</accession>
    <name>A0A1E7N295_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556998.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000597.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3237"/>
    <dbReference type="EnsemblBacteria" id="ARF81842">
        <property type="protein sequence ID" value="ARF81842"/>
        <property type="gene ID" value="B6264_25750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34796">
        <property type="protein sequence ID" value="OEV34796"/>
        <property type="gene ID" value="HS99_0009990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="10189" checksum="B4F7075392FA3E98" modified="2017-01-18" version="1">MSSDEHELWWSPLWGRRKRFAWVDITNVEVVKKNERANAPDIVRITRRVHGVCVLPVLIGLPGSRRDPDVEAKAADLATAWRTATEAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M0</accession>
    <name>A0A1E7N2M0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5891"/>
    <dbReference type="EnsemblBacteria" id="ARF82058">
        <property type="protein sequence ID" value="ARF82058"/>
        <property type="gene ID" value="B6264_27085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34932">
        <property type="protein sequence ID" value="OEV34932"/>
        <property type="gene ID" value="HS99_0035070"/>
    </dbReference>
    <dbReference type="OMA" id="WNAETYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16796" checksum="B100BDF6D15FCC7A" modified="2017-01-18" version="1">MDGAPAGDPDGKAEDDSDGRSDSGTEGGVDGTTQGPSGPSLDSDGHPGPRDRKPVIGSAEWDLLTDGVRWNAETYLLLGCDPGHGPLSLDRLPDRLPEADRPLLRRMMTDALVHGRPAAGTLRIRRPGGRHHSVECAGEPVLGADGTVTALRMLLRPAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S3</accession>
    <name>A0A1E7N2S3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557934.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000328.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4555"/>
    <dbReference type="EnsemblBacteria" id="ARF78509">
        <property type="protein sequence ID" value="ARF78509"/>
        <property type="gene ID" value="B6264_05920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34987">
        <property type="protein sequence ID" value="OEV34987"/>
        <property type="gene ID" value="HS99_0034840"/>
    </dbReference>
    <dbReference type="OMA" id="NQFHYFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="464" mass="51184" checksum="9FBFB37D1DCEA72A" modified="2017-01-18" version="1">MDSARALSDARPTPFWLEDPGRPQALPALVGDATCDLLVVGGGYSGLWTALIAKERDPSLDVVLVEGNEVGWAASGRNGGFCAASLTHGFGNGLERWPAELAQLERLGAANLDAIEATLKRYGIDAEWERTGEIDVATQPHQVEELHEIAEAVARYGLDITVLDADQLRAEVNSPTFLGGLWDKDGVAMVHPAKLAWGLKEACLGQGVRIFEHTRATELREHGSGMAARTPYGRVFARRVALGTNVFPSLLKRVRPYVVPVYDYALMTEPLSDEQLAAIGWRGRQGLGDSANKFHYFRLSADNRILWGGYDAVYHYGGHVRHEYDQRPETFRTLATHFFRCFPQLEGLRFTNAWGGAIDTCSRFSAFFDTAHRGKVAYAVGYTGLGVGATRFGAEVMLDLLAGERTERTSLDMVRSKPLPFPPEPVRWAGIEITTRSLERADRNGGHRNLWLRTLDRLGLGFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N365</accession>
    <name>A0A1E7N365_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3204"/>
    <dbReference type="EnsemblBacteria" id="OEV34893">
        <property type="protein sequence ID" value="OEV34893"/>
        <property type="gene ID" value="HS99_0010160"/>
    </dbReference>
    <dbReference type="OMA" id="WRTAWIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="16588" checksum="683CA22C21949F75" modified="2017-01-18" version="1">MTGVHSLRPVRVDAGPGSGVPLILPKAAAASTLPLLLRRAATVLTVLGMAMIPWLVFLHTGLPATAQASHWAWTWTGLDSSEALGLLATGLLLRRGDCRACLTSAATSALLLVDAWFDAMTAAPGSDFELAVLMAVFAELPLAMACAVLATRTFPRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3G3</accession>
    <name>A0A1E7N3G3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uma2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289478.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1356"/>
    <dbReference type="EnsemblBacteria" id="OEV35226">
        <property type="protein sequence ID" value="OEV35226"/>
        <property type="gene ID" value="HS99_0033470"/>
    </dbReference>
    <dbReference type="OMA" id="NDWVGKV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="20399" checksum="1A0DDB4D9237E187" modified="2017-01-18" version="1">MNPEHFALLEEARRSLPDGFKVEISGDTIVMMVSPSGIHQRNLLLVRRQFDRHAPVDLLPSENTDLVSPNVGKSRNPDLTYLPSEALETSDNQVPSELAAVAVELVSPSNPENDWVGKVRDYPLMGIPLYLLVDARQKTVTLFSRPDGTKYHRREDVDFGETLRIPEPFDFDLVTSDLLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H3</accession>
    <name>A0A1E7N3H3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Erythropoiesis-stimulating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289521.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6129"/>
    <dbReference type="EnsemblBacteria" id="ARF79312">
        <property type="protein sequence ID" value="ARF79312"/>
        <property type="gene ID" value="B6264_10630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35248">
        <property type="protein sequence ID" value="OEV35248"/>
        <property type="gene ID" value="HS99_0033595"/>
    </dbReference>
    <dbReference type="OMA" id="SARNCPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="36668" checksum="A214BF3AAAB23D33" modified="2017-01-18" version="1">MLSVLGLDPDAEAVYRTVLARPELGIAGVAQDLNWPEQRVRDALDGLARLTLIRHSELEPGHLLLVNPEVSLAMLIGRQEAELAERQRQIAQSRLEAAKLVAQYAENRKGERGLGVEQLEGVDQIRLRLEELAHSCTSEIMGFATGGGQSQAARKASQAADQAVFDRGVQMRSIYLESAANDGGTIAHLDWLTERGARVRVAPSLPMRLVIFDREVAVVPTDPDDTSVGALVLSGPGLVSALCALFEYVWENAAPYGKTPARGAEGLNPQTMAVLSLLAQGHTDEVVARRLGVSVRTSRRITAELMAWLGGRSRFQAGVIAGERGLLQGGASAREGQGRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3M2</accession>
    <name>A0A1E7N3M2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0032955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282757.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5284"/>
    <dbReference type="EnsemblBacteria" id="ARF80699">
        <property type="protein sequence ID" value="ARF80699"/>
        <property type="gene ID" value="B6264_18895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35272">
        <property type="protein sequence ID" value="OEV35272"/>
        <property type="gene ID" value="HS99_0032955"/>
    </dbReference>
    <dbReference type="OMA" id="WSYEYTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="31640" checksum="593CA87C1CD5249D" modified="2017-01-18" version="1">MSPNGSDRSPRRTMRRKLPQALALGLVIATATGCSANDLPRLGLPSPVTKEGPMVLQMWQGSWIAALVVGVLMWGLIIWSVIFHRRKRTGVEIPPQTRYNVPIEALYTAVPIIIVSVLFYFVARDEAKLTQVSAKPQHYVNVVGFQWSWAFNYENTETPDPANKDAAYDVGTPKDAPTLWLPVNETVQFRLTSRDVIHDFWPVNFMMKMDVVPGVVNKFEVTPTVKGEYRGKCAELCGVDHSRMLFNVKVVDRADYDKHLADLRAKGQNGAVPSGVITMGSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3X3</accession>
    <name>A0A1E7N3X3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2401"/>
    <dbReference type="EnsemblBacteria" id="OEV35372">
        <property type="protein sequence ID" value="OEV35372"/>
        <property type="gene ID" value="HS99_0032690"/>
    </dbReference>
    <dbReference type="OMA" id="WGLYNTK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="33343" checksum="5A59A7D86FF69754" modified="2017-01-18" version="1">MRAWQVGELGEPAAVMRLADDVARPVPGPGQLLVRVRAAAVNFPDALMVRGQYQVRPPLPFTPGVELCGEVADGARRGERLIGNPVLPHGAFAEYALLDAAAAFPAPEALDDAEAAALHIGYQTAWFALHRRARLRAGETLLVHAAAGGVGSAAVQLGRAAGARVVAVVGGPAKAETARALAADLVVDRTAGDFVAAVKEFTGGRGADVVFDPVGGDAYTGSTRCVAFEGRIVVVGFAAGQIPAPALNHALVKNYAILGLHWGLYNTHDPRAVRAAHDELTKLAEQGVVRPLVSARVPLAGAAEAVQLVADGRSTGRIAVLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y7</accession>
    <name>A0A1E7N3Y7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000225.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3458"/>
    <dbReference type="EnsemblBacteria" id="OEV35395">
        <property type="protein sequence ID" value="OEV35395"/>
        <property type="gene ID" value="HS99_0032835"/>
    </dbReference>
    <dbReference type="OMA" id="FRAMGMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="405"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="542"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="77882" checksum="E8A1B5F7B2CB16F5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4A3</accession>
    <name>A0A1E7N4A3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79404">
        <property type="protein sequence ID" value="ARF79404"/>
        <property type="gene ID" value="B6264_11150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35515">
        <property type="protein sequence ID" value="OEV35515"/>
        <property type="gene ID" value="HS99_0031960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7950" checksum="D9CDA59FBCCFF5F8" modified="2017-01-18" version="1">MREPIAPLGTWLFVPDRRNAVGDVSTGYLSRNGERVVLSHTSRPLADLVRKIGQLESDFAARIGALLFPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4I3</accession>
    <name>A0A1E7N4I3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="12" type="ORF">HS99_0006725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene980"/>
    <dbReference type="EnsemblBacteria" id="ARF80800">
        <property type="protein sequence ID" value="ARF80800"/>
        <property type="gene ID" value="B6264_19495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35607">
        <property type="protein sequence ID" value="OEV35607"/>
        <property type="gene ID" value="HS99_0006725"/>
    </dbReference>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="44350" checksum="792345913CE0EFBF" modified="2017-01-18" version="1">MSEKDYLPGAQVPDARGYFGAYGGRFIPEALVAAVEQVAEEYEKAKADPAFAAELDGLLKDYTGRPSPLTDVHRFSAEAGGARILLKREDLNHTGSHKINNVLGQALLTRRMGKTRIIAETGAGQHGVATATACALFGFDCTIYMGEVDTERQALNVARMRMLGAEVIAVKSGSRTLKDAINEAFRDWVANVDSTHYLFGTVAGPHPFPMMVRDFHRIIGVEARQQVLDRTGRLPDAVVACVGGGSNAMGIFHEFIPDAGVRLIGCEAAGEGADTPKHAATLTKGDPGVLHGSRTYVLQDEDGQTVESHSISAGLDYPGVGPEHAWLKDTGRAEYRPVTDDAAMQALRLLSRTEGIIPAIESAHALAGALDLGRELGPEATILVSLSGRGDKDMHTAAQYFGLYDEPAGDRAEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K4</accession>
    <name>A0A1E7N4K4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550061.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5377"/>
    <dbReference type="EnsemblBacteria" id="ARF80777">
        <property type="protein sequence ID" value="ARF80777"/>
        <property type="gene ID" value="B6264_19360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35584">
        <property type="protein sequence ID" value="OEV35584"/>
        <property type="gene ID" value="HS99_0006595"/>
    </dbReference>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="29749" checksum="480FB89EF33B86A0" modified="2017-01-18" version="1">MELKGIHIPLITPFAADGSVALDALEKLAHEVLDAGAAGLVALGTTGEPAALTAEERDAVVDVAAAVCADRGAQLTVGASGGDTRAVGEALAALGARVPRAAALVTTPAFVRAGEAGTVAHFRALAASSPLPLVVYHIPYRTGQQLSTAAMRELAAIDGVVGVKYATGGLDRSAVELLADTPAGFALMTGEDAFLAPMLALGAAGGILASAHLATRRFVELYEAWQAGDVERARALGHRLTALALSAFTAPNPTVTKGVLHAQGRIPTPNVRLPLLPAGETEVAAALALASGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y3</accession>
    <name>A0A1E7N4Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0007515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene825"/>
    <dbReference type="EnsemblBacteria" id="OEV35732">
        <property type="protein sequence ID" value="OEV35732"/>
        <property type="gene ID" value="HS99_0007515"/>
    </dbReference>
    <dbReference type="OMA" id="YGNHDME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="3">
        <location>
            <begin position="77"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="215"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="550" mass="60578" checksum="BEAE12D72F0256C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N520</accession>
    <name>A0A1E7N520_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385932.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene750"/>
    <dbReference type="EnsemblBacteria" id="ARF80997">
        <property type="protein sequence ID" value="ARF80997"/>
        <property type="gene ID" value="B6264_20670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35786">
        <property type="protein sequence ID" value="OEV35786"/>
        <property type="gene ID" value="HS99_0007895"/>
    </dbReference>
    <dbReference type="OMA" id="GHRHVRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20241" checksum="B4CFBA080AF38E47" modified="2017-01-18" version="1">MTVTVNTRPTAEGLLLRPFEDADAPALIEAYRDDTLRRFTRVPVTDAEQAARWLGIQYEGRAAGTRYSFAVLEAGELVANVALKRGAPGGATAEVGYWTAAPARGRGVAPRAVEALTAWAFAAFAEDGLRRIDLLHQVDNIASCRVAEKSGYVFQELLTALPPEFPLDGHRHSRKALDVIERHGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N548</accession>
    <name>A0A1E7N548_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exodeoxyribonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835615.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3367"/>
    <dbReference type="EnsemblBacteria" id="ARF81041">
        <property type="protein sequence ID" value="ARF81041"/>
        <property type="gene ID" value="B6264_20945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35831">
        <property type="protein sequence ID" value="OEV35831"/>
        <property type="gene ID" value="HS99_0008165"/>
    </dbReference>
    <dbReference type="OMA" id="LRHGWAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029493">
        <property type="entry name" value="RecD-like_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14490">
        <property type="entry name" value="HHH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="72440" checksum="0B3116D36F436712" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N554</accession>
    <name>A0A1E7N554_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286073.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000957.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3371"/>
    <dbReference type="EnsemblBacteria" id="ARF81037">
        <property type="protein sequence ID" value="ARF81037"/>
        <property type="gene ID" value="B6264_20925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35827">
        <property type="protein sequence ID" value="OEV35827"/>
        <property type="gene ID" value="HS99_0008145"/>
    </dbReference>
    <dbReference type="OMA" id="VHSPGVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="7597" checksum="D0C456104B9665E2" modified="2017-01-18" version="1">MMKVKKIAAVAAATGGLVLAAAGVASAHGGAGAEGVAAGSPGVVSGNQVQIPVHVPVNVCGNTVSVIGLINPAFGNHCANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A4</accession>
    <name>A0A1E7N5A4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81083">
        <property type="protein sequence ID" value="ARF81083"/>
        <property type="gene ID" value="B6264_21175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35871">
        <property type="protein sequence ID" value="OEV35871"/>
        <property type="gene ID" value="HS99_0008400"/>
    </dbReference>
    <dbReference type="OMA" id="VYVIVDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22361" checksum="234F126035DB3099" modified="2017-01-18" version="1">MSAAAVEGPFEQAPPLEAAEQPTLLEAAELISNQLVGYRVEIVGSQITVTPPPNASHGKSLSRLMRALFAAGLDGEEVEVLQNIGIWLPDGPSDYAVPDLSIVDADIDDHVIEYNCYDPAVFRLVLEVTSSNLSDDLKRKPTVYASAGVPVYVIVDRKNQRVMVLTDPKDSEYQVHAVHHPGQSFTLPESIGATVTLSVDDVLSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N619</accession>
    <name>A0A1E7N619_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386571.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7283"/>
    <dbReference type="EnsemblBacteria" id="ARF81114">
        <property type="protein sequence ID" value="ARF81114"/>
        <property type="gene ID" value="B6264_21350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35903">
        <property type="protein sequence ID" value="OEV35903"/>
        <property type="gene ID" value="HS99_0008575"/>
    </dbReference>
    <dbReference type="OMA" id="ERDGWIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15928" checksum="7590F9525FC316A7" modified="2017-01-18" version="1">MELDKSADRPSPIEFRLDPASGVPTYLQLVQQVEQALRMGWLAEGDRLPRVREVVAGLAINPNTVLKAYRELEHRGLAAGRRGQGTFVRGMPAGVVPLRERAALRRGLLDWMRSARAAGLDEGGMVAVFEDALRDLREGRDGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G8</accession>
    <name>A0A1E7N6G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284349.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000314.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8106"/>
    <dbReference type="EnsemblBacteria" id="ARF82813">
        <property type="protein sequence ID" value="ARF82813"/>
        <property type="gene ID" value="B6264_13515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36244">
        <property type="protein sequence ID" value="OEV36244"/>
        <property type="gene ID" value="HS99_0030470"/>
    </dbReference>
    <dbReference type="OMA" id="WQLPVRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="30378" checksum="2BBAA8C0899B65BA" modified="2017-01-18" version="1">MPTLRREIPRDEVPLDFPRAWVEFADPADDEQVFRCDLTWLTSRWSCVFGQGCHGIREGRGESDGCCTLGAHYSDEDDEKRVLGHAARLTPELWENFAEGTDAKGRIRSDGGVTMLDEDGDRQTRRVNGACIFVNSPGFAGGAGCALHALALKEGREPLETKPDVCWQLPIRRTYDWIDRPDDTRYLQVSIGEYDRRGWGPGGHDLHWWCTGAPAAHQGAEPVYVSYRPELTELMGRKAYEVLARLCEERIATKGDRKVAPHPADPAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J2</accession>
    <name>A0A1E7N6J2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0029610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386987.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000604.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4883"/>
    <dbReference type="EnsemblBacteria" id="ARF82384">
        <property type="protein sequence ID" value="ARF82384"/>
        <property type="gene ID" value="B6264_29050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36326">
        <property type="protein sequence ID" value="OEV36326"/>
        <property type="gene ID" value="HS99_0029610"/>
    </dbReference>
    <dbReference type="OMA" id="FDQHEIG"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="36696" checksum="E4E9097A5956B0D2" modified="2017-01-18" version="1">MRKVLITGGAGFIGSTVASALLDRGITPVVLDDLSRGRAEFVEDRVFYDGDIADAALLERIFTEHPDIDATVHCAARIVVPESVAKPLFYYRENVAKTVELLDALQRHGCTRVVFSSSASIYAPTPDGRVDENSPVEANSPYARTKLMMEQVLQDWTRGEGAEQQRVIALRYFNPIGADPRLRTGLQNLNPSHALGKLIEAHTHGTPFTVTGVDWPTRDGSGIRDYVHVQDLAEAHVAALLRFDEVIAPGAADRYRAINVGTGEGTTVRELVAAFERAVGTELDVREAGPRPGDVIGCYASVDAARELLGWTAKHSLAEGVADALAWRARWATRLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J6</accession>
    <name>A0A1E7N6J6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionyl-tRNA formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550852.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2619"/>
    <dbReference type="EnsemblBacteria" id="OEV36298">
        <property type="protein sequence ID" value="OEV36298"/>
        <property type="gene ID" value="HS99_0030290"/>
    </dbReference>
    <dbReference type="OMA" id="VEWTIRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25099" checksum="9A4CC4348271225E" modified="2017-01-18" version="1">MHIYLSGQGAFAVQVAEALLDEGHKIVGAAAPRLRKGQSDEGNAMCWDRLRSWAYPRDIPWTDSAELRARHVPDGVDIILAAHSHAFLGRETRARAAVAAIGYHPSLLPLHRGRDAIRWTVRDGDKVTGGSVYHLTERTDGGPIAAQEHLFVPPGSTARSLWHDHLAPLGVRLLVKVVTDLAAGRRIEVPQDEALATWEPAMGAPPLFKPELIALPGTAQVDGSRWALHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L3</accession>
    <name>A0A1E7N6L3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366350.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82363">
        <property type="protein sequence ID" value="ARF82363"/>
        <property type="gene ID" value="B6264_28925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36346">
        <property type="protein sequence ID" value="OEV36346"/>
        <property type="gene ID" value="HS99_0029730"/>
    </dbReference>
    <dbReference type="OMA" id="VEPVPAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="25691" checksum="C7B096B376591B60" modified="2017-01-18" version="1">MRLIGAAVGVVAMCALVGGATAAGAERPGGSPHGSAVDTCVCIGTGVSTSVGPGGSVDVGVDVDVRVDVTVAPDVGRHHGHRPPHHHHPHPCPSPTPTPVPTHTPTPTPTPTPTPTRTPTPTPAPSPSATPPRPTPVPTPPPSPGPPAPPPPVPAAPAPAAPEPAVPAPQVVPPAVVPLPAAPAPADPSPALPSPVRPSPLWPTPSAHPAFKVWDSKPLPVAQHNHGASTTTTMLLIFVPGILAAAALRPGRAGGRGRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T2</accession>
    <name>A0A1E7N6T2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0029170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554839.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7789"/>
    <dbReference type="EnsemblBacteria" id="OEV36417">
        <property type="protein sequence ID" value="OEV36417"/>
        <property type="gene ID" value="HS99_0029170"/>
    </dbReference>
    <dbReference type="OMA" id="IRQQDAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198822" evidence="3">
        <location>
            <begin position="40"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="804" mass="86651" checksum="1FEC5027FB81F54B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y0</accession>
    <name>A0A1E7N6Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554217.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene201"/>
    <dbReference type="EnsemblBacteria" id="ARF82239">
        <property type="protein sequence ID" value="ARF82239"/>
        <property type="gene ID" value="B6264_28185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36456">
        <property type="protein sequence ID" value="OEV36456"/>
        <property type="gene ID" value="HS99_0029420"/>
    </dbReference>
    <dbReference type="OMA" id="LPTLDMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="31094" checksum="0E9A186070016D4E" modified="2017-01-18" version="1">MAPTIPGFDHLRLPGADGVQLTAAVGGNGSGSPVVLLHGFPQTHLMWRHVAERLADEHTVICPDLRGYGASDKPAGTGPEVYAKRTMAADVVALAAALGHDRFALVGHDRGALVAFRAGLDHPDTVTHLGILDVVPTLDMWNVLHGVSAAVGYHLYLMAQPPGLPETMIANSADAFFGSFLDAWADDPAVLPPEVRAEYLRASAAAVASIVADYRASAGVDVRHDQADLDAGSQLAMPVTVVQQDWGARLGYDAAAVWRAWAPDLDHRLTGAGHFMAEEAPEEITSAVRDLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N780</accession>
    <name>A0A1E7N780_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase sulfur carrier subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289664.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000319.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7882"/>
    <dbReference type="EnsemblBacteria" id="ARF79146">
        <property type="protein sequence ID" value="ARF79146"/>
        <property type="gene ID" value="B6264_09640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36550">
        <property type="protein sequence ID" value="OEV36550"/>
        <property type="gene ID" value="HS99_0028945"/>
    </dbReference>
    <dbReference type="OMA" id="FPGMRFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9514" checksum="6359F6B31DCE0E85" modified="2017-01-18" version="1">MSANVRIPTILRTYTGGAAEVPAGGATLAEVIADLEKNHAGISARILDDTGKLRRFVNVYVNDDDVRFADGLATEIKDGASVSIIPAVAGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B8</accession>
    <name>A0A1E7N7B8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552627.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7903"/>
    <dbReference type="EnsemblBacteria" id="ARF79129">
        <property type="protein sequence ID" value="ARF79129"/>
        <property type="gene ID" value="B6264_09540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36568">
        <property type="protein sequence ID" value="OEV36568"/>
        <property type="gene ID" value="HS99_0029045"/>
    </dbReference>
    <dbReference type="OMA" id="FEHTAFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="21092" checksum="46FB38562CB70EC8" modified="2017-01-18" version="1">MPEFVPQQKITEFVNDGFEHTAWRLETRTGYLSDKHMPSYAEFLRTGDTAGEVGHPWFETVRRMVGKGKRFERVRLVDSPPREGQQYLLACARTNMAAGEDIRYMWRSEAEAVGLGGLSDFWLFDSRTVARFHFDGERTVGMELITEPVEVLRACQARDATWHYATRYSEFRARVSEEAAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D4</accession>
    <name>A0A1E7N7D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289695.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7914"/>
    <dbReference type="EnsemblBacteria" id="ARF79120">
        <property type="protein sequence ID" value="ARF79120"/>
        <property type="gene ID" value="B6264_09490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36578">
        <property type="protein sequence ID" value="OEV36578"/>
        <property type="gene ID" value="HS99_0029095"/>
    </dbReference>
    <dbReference type="OMA" id="WVIQRFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="28963" checksum="B5767F4B7A1515A4" modified="2017-01-18" version="1">MDSPEPDRCRGVLHPAHAAELISVERLVPAAEVARFVEFYWLVRWDLTGHPPYEQKVLAHPNVHLVFEAPRARVYGVDRALFVRRLEGTGHVLGVKFRPGAFRPFAGHPVGDLADRSVPAADYFGPEVDRINARILDEPTAERVDEFLRPRLPAPDPVAEEVAAMVERITGSPDLCRVDELARELGVSVRSLQRLFAEYVGASPKWVLRRARLHEAAERAANEGKLDLAALAVELGYADQAHLTRDFTAAVGVSPARYAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F2</accession>
    <name>A0A1E7N7F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385512.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7773"/>
    <dbReference type="EnsemblBacteria" id="ARF82296">
        <property type="protein sequence ID" value="ARF82296"/>
        <property type="gene ID" value="B6264_28530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36621">
        <property type="protein sequence ID" value="OEV36621"/>
        <property type="gene ID" value="HS99_0027985"/>
    </dbReference>
    <dbReference type="OMA" id="VWDYQEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="44538" checksum="7471CCC1F236F2B2" modified="2017-01-18" version="1">MTERQTNRTAETSADVVILGAGPAGLTLGNLLHAAGIDCVVLERADRAHVRTRARAGFLAANTVRILERHGLADGLHRRGHPHGTCEFRTGNGSFRLDYGTLGRGERHTVYPQQDLVTDLLTHYLDAGGRIRFETEARSVREVTGPRPTVDVREADGRPGRWRARYVAGCDGRHGAARRSLPASALRHHRDHGVTWLGLLAEAPPSLDAVGYAMHPDGFAGHMARTADITRYYLQYEPGVPGDAWSEERIWAALDRRMYTAEHGPLHHGRIVQRSVINLESDVVEPLRHGSLLLAGDAASLPAPAAAKGANLAVLEAELLAEALIDEFSRSDSRALDRYSRRCLDHIWRAQEFAHWMIQLLHAPAGADAESFFHEAMRRSRVESLRTSRTHQDWFAENYVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M0</accession>
    <name>A0A1E7N7M0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550720.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2507"/>
    <dbReference type="EnsemblBacteria" id="ARF81497">
        <property type="protein sequence ID" value="ARF81497"/>
        <property type="gene ID" value="B6264_23585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36669">
        <property type="protein sequence ID" value="OEV36669"/>
        <property type="gene ID" value="HS99_0028295"/>
    </dbReference>
    <dbReference type="OMA" id="TTAWWKE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="38149" checksum="79524ADCE15727B0" modified="2017-01-18" version="1">MGSAVELEVAGRTVRLSNPDKVYYPERGFTKLDVAQYYLAVTDGVLRGLRDRPTTLQRFPEGVDGEFFYQKRAPKGLPDWLPTARIEFPSGRSADEICPTEPAAVLWAANLGCLTFHPWPVRRTDTDHVDELRIDLDPQPGTDFRDAVRAAHELRALLEEHGLRGWPKSSGGRGLHVYVPLVPEWTFTDGRHAVIALGRLLEQRLPGKVTTAWWKEERGERIFVDYNQMARDRTIASAYSLRARPRATASTPLRWEELDDAAPEDFDLRTVPARFAELGDLNAEMDGHAYRLDSVLELYEKQLHDEGLGELPYPPDHPKAAGEPTRVQPSRARKKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N806</accession>
    <name>A0A1E7N806_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4838"/>
    <dbReference type="EnsemblBacteria" id="ARF82421">
        <property type="protein sequence ID" value="ARF82421"/>
        <property type="gene ID" value="B6264_29275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36798">
        <property type="protein sequence ID" value="OEV36798"/>
        <property type="gene ID" value="HS99_0027735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20126" checksum="807B3466CA36AE3B" modified="2017-01-18" version="1">MARSGWARPVAEAEAVLVRHYRRLGEATAQDALQAWARAGCAVPDGTPGVKQLNLWAFAVQPLPQNAGSAAWFCLRADRWTGEGSAATAVLLPSARGPQRTGGGPGRSCSRFEQDTVAWTWWRSPQGAEYLLAAGSRRVTRLIVRGPDWSVDRPAPDRTLAVERPARAAVRVEALLDNGSRLNPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N817</accession>
    <name>A0A1E7N817_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4822"/>
    <dbReference type="EnsemblBacteria" id="ARF83147">
        <property type="protein sequence ID" value="ARF83147"/>
        <property type="gene ID" value="B6264_29355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36840">
        <property type="protein sequence ID" value="OEV36840"/>
        <property type="gene ID" value="HS99_0027655"/>
    </dbReference>
    <dbReference type="OMA" id="DCSCGIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="28032" checksum="343EB8C896C32BC7" modified="2017-01-18" version="1">MTSSELGRFYDDFARDYHLLYADWDASLARQGGALDALIRARLGEAPAEVLDCACGIGTQAIGLAALGHAVTGTDLSPVAVARAAAEAAGRGLRLPAAAADMRRLPFPDGRFDVVVCADNALPHLLTAEDVRAALGEMRRVLRPGGLLLVSTRPYDRLRRDRPASTPPQTAERDGRRSVVFQLWHWREDGEHYDLELFQLLPDDAAQWRVTVRRSSYWALGQAQLSSFAAEAGLVGADWEQPDATGFFQPLLIARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N829</accession>
    <name>A0A1E7N829_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36623">
        <property type="protein sequence ID" value="OEV36623"/>
        <property type="gene ID" value="HS99_0027995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="21907" checksum="EB75E1CEFB09BDC2" modified="2017-01-18" version="1">MFGLLCFVVAFAKEAASGAGISLPGPKSGGARVGVVAVGILALILGTAIRPQGGTPAEPAPAAGAAVSPQGAAAPGAATASAGAGTTATAAPAPPAPSPTGLAAVWTGQVGIPFEGGIDLDLTPPGRHPGFPQGIYATGFSSTEAVLRDEIQMDHDTFGLWTGQAPPSGPACADWAASHAGDSVHVKAGSLVCLRTPGGRTALIKVDSIAPADYQVEATVTLWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N838</accession>
    <name>A0A1E7N838_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name evidence="2" type="ORF">HS99_0026705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6442"/>
    <dbReference type="EnsemblBacteria" id="ARF78694">
        <property type="protein sequence ID" value="ARF78694"/>
        <property type="gene ID" value="B6264_06980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36860">
        <property type="protein sequence ID" value="OEV36860"/>
        <property type="gene ID" value="HS99_0026705"/>
    </dbReference>
    <dbReference type="OMA" id="FRFGRIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0139">CF(1)</keyword>
    <keyword evidence="1" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="28555" checksum="8EEB59C8A0843ADB" modified="2017-01-18" version="1">MIGASREALAAGRQNLDSLTDSTSVDAAKLAEELTAVTAVLDREVSLRRVLTDPSRSGQDKAQLITSLLTGQVSGETVDLVSGLVRSRWSGSRDLVDAAEELAAYAEIIAADKAGVLDDVEDELFRFGRVVSGSHELRAALTEPKAGAAAKSELVKKLLGGRTNAGTVRLVTALVNAPRGRSLEQGLESYSKLAAARRGRMVALVTSAVPLSDAQKERLSGALGRMYGRQVHLNIDVDPEVVGGVRVQIGDEIIDGTVSSRLEGARQSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N843</accession>
    <name>A0A1E7N843_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366572.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6449"/>
    <dbReference type="EnsemblBacteria" id="ARF78687">
        <property type="protein sequence ID" value="ARF78687"/>
        <property type="gene ID" value="B6264_06945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36867">
        <property type="protein sequence ID" value="OEV36867"/>
        <property type="gene ID" value="HS99_0026740"/>
    </dbReference>
    <dbReference type="OMA" id="EIGFWVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21939" checksum="779416621BB2B8D7" modified="2017-01-18" version="1">MIVTLIAAAEISWWIVLGLALSTRYLLRWRRTSTVLLLGLPAVDLVLYTLTVLNLRGGAEANWMHALAASYAGFSVGYGPSLVAWADRHFLYRFAGGPKPLPAPKYGPERTRHEWRVAARTVVSAVITLALITLLVPLSNGAAHVGTFTEWYIRLTIVAVVNLIVAGCYSLWPKEPPAGVRVEHGRVAESGEPAEKAQDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K1</accession>
    <name>A0A1E7N8K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0004125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7480"/>
    <dbReference type="EnsemblBacteria" id="OEV37025">
        <property type="protein sequence ID" value="OEV37025"/>
        <property type="gene ID" value="HS99_0004125"/>
    </dbReference>
    <dbReference type="OMA" id="RELHQAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26625" checksum="C180BC115A8D1D61" modified="2017-01-18" version="1">MGDIVRLTAVHKTYGRGNNRVRALDGVDIDFEAGTFTAIMGPSGSGKSTLLQCAAGLDRVDAGQVLLDGAPLHELSERSLTELRREHMGFIFQSFNLIPALTARQNVELPLRLAERPIDSVAIDRGLAEVGLAERGEHRPAELSGGQQQRVAIARALVTRPKVIFADEPTGALDSRTAREVLALLRGVVEEHGQTVIMVTHDPVAASYSQRVVFLADGKVTGELFEPTAETVALRMTALEPGGSGANPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8M0</accession>
    <name>A0A1E7N8M0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556157.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7459"/>
    <dbReference type="EnsemblBacteria" id="ARF81683">
        <property type="protein sequence ID" value="ARF81683"/>
        <property type="gene ID" value="B6264_24760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37045">
        <property type="protein sequence ID" value="OEV37045"/>
        <property type="gene ID" value="HS99_0004245"/>
    </dbReference>
    <dbReference type="OMA" id="HEAGTRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="607" mass="63594" checksum="F7AE011956626DE6" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R2</accession>
    <name>A0A1E7N8R2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556069.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7408"/>
    <dbReference type="EnsemblBacteria" id="ARF81642">
        <property type="protein sequence ID" value="ARF81642"/>
        <property type="gene ID" value="B6264_24495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37086">
        <property type="protein sequence ID" value="OEV37086"/>
        <property type="gene ID" value="HS99_0004495"/>
    </dbReference>
    <dbReference type="OMA" id="WNGTVGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="30172" checksum="F51531F38C06750D" modified="2017-01-18" version="1">MRYFVAVAEELHFGRAATRLHISQPPLSRAIKQLEAEVGALLFTRSPTGVMLTTVGSVLLDEARSLLDHADRVRVRVSAAAGVATLTVGILGDGTDPGVARLAAAFRRSHPGVDIRIRDADLTDPTCGLRAGLVDIALTRAPFDETALTVRALRTDPVGVVLRADDPLARRDGLRLAELDDRRWFQFPPGTDPEWQSYWNGGTPREGPVVRAVQECLQTVLWNGTVGLAPLGHDLPAELAVVPLVDMPPSRVVAVWNEGDTNPLIRSFVRTATAAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W6</accession>
    <name>A0A1E7N8W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81588">
        <property type="protein sequence ID" value="ARF81588"/>
        <property type="gene ID" value="B6264_24170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37145">
        <property type="protein sequence ID" value="OEV37145"/>
        <property type="gene ID" value="HS99_0004820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9587" checksum="753E1C59B0EA6662" modified="2017-01-18" version="1">MSLPTARAMGLANPRSAVRLRLWTAVGTAPVQLGTHDEAHGIAAERIEAARGLDRRTERMCLDVDRGPHVTGQARGQGLGVPAGGHEAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N957</accession>
    <name>A0A1E7N957_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556569.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6170"/>
    <dbReference type="EnsemblBacteria" id="OEV37198">
        <property type="protein sequence ID" value="OEV37198"/>
        <property type="gene ID" value="HS99_0005150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198898" description="PG_binding_1 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13471" checksum="628E8116DE765BA1" modified="2017-01-18" version="1">MTEFRRRMAAVTASAAIALGGVVALAPQASADEACSYVPDNARPYVYPNQSNDAVRQAQCLILFYSGFGMNHAVQIDGKYGQETYAGVIWVQHCNGLSEDGIVGPNTWEKLYNPNYACQRFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N986</accession>
    <name>A0A1E7N986_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555257.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37228">
        <property type="protein sequence ID" value="OEV37228"/>
        <property type="gene ID" value="HS99_0005345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198903" evidence="1">
        <location>
            <begin position="33"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="14405" checksum="A0AD4632DB860EAC" modified="2017-01-18" version="1">MNKSVGRRAATAAAALAATLGGLLLAGGTASAAPLQAVHHDTTVSVSSAAFQVRDDEGDHSDRFDRYGGGHASRWDGHRSWERQGSYWYSNDHGHRYRYDDHRFYRWDNGWQIIQVINVYGFNPHVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C5</accession>
    <name>A0A1E7N9C5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555110.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1266"/>
    <dbReference type="EnsemblBacteria" id="OEV37295">
        <property type="protein sequence ID" value="OEV37295"/>
        <property type="gene ID" value="HS99_0005745"/>
    </dbReference>
    <dbReference type="OMA" id="AWSAEST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="158"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28400" checksum="9DEB96D3A310B37C" modified="2017-01-18" version="1">MQKNLELPDLLRLIDERATAFRAAIAAAPSLDVQVPTCPEWTLFDLARHLGSGRPFWAAVVEAGPADAPPAEAVAARAEAQAPREREALVAWLAASTQELLDTLREVGPDAECWTWWGASQSPRTSGAVARHQLQEIAVHAYDAQLTVGAAQPLPAQVALDGVEDFLFTCCAWSGVWPHEPAVVDYHATEGRSWRFTVEADGARAVRLPAAGEGEAQAPADASARGTAGELVLWFYGRTPLDSVKIDGDRVIFERLFAWDPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q1</accession>
    <name>A0A1E7N9Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyl-gamma-aminobutyrate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385882.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene143"/>
    <dbReference type="EnsemblBacteria" id="OEV37412">
        <property type="protein sequence ID" value="OEV37412"/>
        <property type="gene ID" value="HS99_0003900"/>
    </dbReference>
    <dbReference type="OMA" id="PEYWAET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="26106" checksum="EAE3124CF0462576" modified="2017-01-18" version="1">MTATGTTPPDGHRRPLIGISSYQDDAAWSVWNQRACLVPQTYVDAVVRAGGTPVLLPPQPGGTGHLLDALDGLVLAGGPDVDPSRYAAAPHPRTGPPHHTRDDWESRLLHAALARDLPVLGVCRGMQLLNVELGGTLVQHLPDDSHQIVPARFARHRVTPVHGSRLAAVLGPATEVSCYHHQAVDRIGTGLRATAHSADGTVEALELTGHRFALGVQWHPETDSDDLRLFHAFITASQRETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA23</accession>
    <name>A0A1E7NA23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366622.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1151"/>
    <dbReference type="EnsemblBacteria" id="ARF79029">
        <property type="protein sequence ID" value="ARF79029"/>
        <property type="gene ID" value="B6264_08950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37541">
        <property type="protein sequence ID" value="OEV37541"/>
        <property type="gene ID" value="HS99_0026405"/>
    </dbReference>
    <dbReference type="OMA" id="TDELHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="57551" checksum="7C160F531ABE048B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC1</accession>
    <name>A0A1E7NAC1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ORF">HS99_0026020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367137.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7946"/>
    <dbReference type="EnsemblBacteria" id="OEV37584">
        <property type="protein sequence ID" value="OEV37584"/>
        <property type="gene ID" value="HS99_0026020"/>
    </dbReference>
    <dbReference type="OMA" id="PEPNAMV"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="23622" checksum="BE69C531960FC8A2" modified="2017-01-18" version="1">MRKHYTHEGLAEEQLAPEPVAQFARWFLEADGAGVVEPNAMVLSTADAQGRPSSRTVLLKGYDVRGFVFFTNYGSRKGSELAVNPHAGLLFPWIALARQVIVQGRVEKVGRDETAAYFRTRPHGSQLGAWASEQSSPVSGRDVLEQRYADLERRYPEGEGVPVPPFWGGYRVVPESVEFWQGRENRLHDRLRYLADPASPTGWRVERLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK3</accession>
    <name>A0A1E7NAK3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name evidence="4" type="ORF">HS99_0025700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280807.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1654"/>
    <dbReference type="EnsemblBacteria" id="ARF79955">
        <property type="protein sequence ID" value="ARF79955"/>
        <property type="gene ID" value="B6264_14490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37698">
        <property type="protein sequence ID" value="OEV37698"/>
        <property type="gene ID" value="HS99_0025700"/>
    </dbReference>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="17268" checksum="CAC684DEFEC7B604" modified="2017-01-18" version="1">MPRPTKGARLGGGPHHEPLLLAGLARELFQYGRITTTEAKARRLRPLAEKLITKAKKGDIHNRRLVRKTITDVSVLHTLFTEIAPRYENRPGGYTRITKIGPRRGDNAPMAVIELVEALTVAQTAVGEAEAATKRAVKEADEAAAVDTKADEAEAAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB82</accession>
    <name>A0A1E7NB82_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2056"/>
    <dbReference type="EnsemblBacteria" id="ARF79506">
        <property type="protein sequence ID" value="ARF79506"/>
        <property type="gene ID" value="B6264_11790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37952">
        <property type="protein sequence ID" value="OEV37952"/>
        <property type="gene ID" value="HS99_0024115"/>
    </dbReference>
    <dbReference type="OMA" id="WWMRVGE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="55085" checksum="E5B95D969FF84A49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBB5</accession>
    <name>A0A1E7NBB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278305.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000452.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2064"/>
    <dbReference type="EnsemblBacteria" id="ARF79499">
        <property type="protein sequence ID" value="ARF79499"/>
        <property type="gene ID" value="B6264_11750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37944">
        <property type="protein sequence ID" value="OEV37944"/>
        <property type="gene ID" value="HS99_0024075"/>
    </dbReference>
    <dbReference type="OMA" id="VYAGMQI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="450" mass="47083" checksum="232AD72D3B9B4916" modified="2017-01-18" version="1">MTVEPARSAAAPSPSSSEPAPRAAAATPAVTVVQAAPPGGRAAWVAWSIGVSVYVLAVVHRTSLGVAGLDAAERFGIGASALSTFSILQVLVYAAMQVPVGLLVDRFGPRRVLLLGVLLLSTGQLAFAFSSSFAPALASRAVLGCGDAMTFISVLRIAARWFPAAKNPFVAQLTGLAGMGGNLVSTVVLAQALHSEGWTPTFTAVALLGVAVFALVALFLREAPAAVRPVDPPTAAARPKVRRQVLDCWREPGTRLGLWVHFTTQFPGNAFGLLWGMPYLVEAQGMSRGEAGGLLTLLVLSNMSFGFLFGRLLSRTARARMPIVLTVITTTGLGWALVLAWPGGHPPMWLLVGIILVMGSNGPASLVGLDYARTRNPAERLGTASGIVNMGGFIGTMITLFGIGVLLDAVSPAGAEAYSATAFRWAFCWQYVPLAVGTLMILRLRRKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK6</accession>
    <name>A0A1E7NBK6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase HS99_0023000</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0023000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386116.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000223.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3024"/>
    <dbReference type="EnsemblBacteria" id="OEV38072">
        <property type="protein sequence ID" value="OEV38072"/>
        <property type="gene ID" value="HS99_0023000"/>
    </dbReference>
    <dbReference type="OMA" id="FLWVRIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="102"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="45913" checksum="148D6FC35C5F04DA" modified="2017-01-18" version="1">MGKSIDDTAVDTVNGVQVRAVSVDEVEEWNRALNFGFLRPHAGVAPDLRRRQWQPGRMVAGFDGERQIATFRSFDVELTVPGGAVVTADAITNVTVSSTHRRRGVLSAMMRRDLASAAERGCAVAILAAAEYNIYGRFGFGPATWGSGWRIDLGRTSGLREGLPGVPGGRIDFVTLAEQRELGAELYDRWRLTQPGAIARDGIWWERNTNVIQVPGDSFKEPFAAVHRDADGGVTGMVVYRIDNKWEGALPAGTLTVHDFLALDLPTAVELWRLVLSVDWVRKVVVQGVSPDDPLPLLLQDPRAAVPDEANADLMWLRLLDVGAAFGARTYGAAGRVVLEVEDRLGYASGRFAIEVAEDGTGRCTRTTDDADLALGAGALGSLYLGSETAPRLAAAGLLTELRPGAAAAADLLLRTPLRAWTPTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBV3</accession>
    <name>A0A1E7NBV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene463"/>
    <dbReference type="EnsemblBacteria" id="ARF78851">
        <property type="protein sequence ID" value="ARF78851"/>
        <property type="gene ID" value="B6264_07910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38165">
        <property type="protein sequence ID" value="OEV38165"/>
        <property type="gene ID" value="HS99_0023545"/>
    </dbReference>
    <dbReference type="OMA" id="DSYFYLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17299" checksum="C5F41AC9102453B6" modified="2017-01-18" version="1">MLTLEPLRPDHADAVFAFELANRAWFARTVPDRGDAYFAGFAERHAALLAEQAAGVCRFHVVLDPTGTLVGRINLMDLVDGSAELGYRIAESAAGRGVAKAAVAQVRRLAAHSYGLRSLTAVTTLDNPASMAVLAHNGFAVIAEFLLDGRPAVRYHRGLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB5</accession>
    <name>A0A1E7NCB5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366756.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000359.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4131"/>
    <dbReference type="EnsemblBacteria" id="OEV38332">
        <property type="protein sequence ID" value="OEV38332"/>
        <property type="gene ID" value="HS99_0022705"/>
    </dbReference>
    <dbReference type="OMA" id="SCAIPGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="369" mass="37979" checksum="69DBD5C51C3B1A44" modified="2017-01-18" version="1">MTTRTAVSGTSPGGAPRRGLVLGGGGMLGAAWTVGALCAVEEVTGLRPGETDLLLGTSAGAILAALLAGGVPPEQLRDHQRGLAVTEGPLAGVAFDYETAVGGALPQRPRAGIGSPDLLRDAVRHPREYPLLTMVSAMAPHGRGSLAPVGELVRGLFGPGGWPAPGSSGPTAAGVAPSAAAAPLRVAAVDYRSGHRVVFGDPEAPAVAVADAVMASCAIPGWFAPVRLDGSAYVDGGCWSATSADLLLGRGLDEVYVLAPMALRLGPRPERSDRSTLAALREWRARDRPRGVLAQLVSRYRRAVTRQLLREAALLRAEGVRVRLLAPTLADLAVMGPNLMDPARRGEVLESALRTSRAALAAERGPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD0</accession>
    <name>A0A1E7NCD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557838.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7151"/>
    <dbReference type="EnsemblBacteria" id="OEV38133">
        <property type="protein sequence ID" value="OEV38133"/>
        <property type="gene ID" value="HS99_0023355"/>
    </dbReference>
    <dbReference type="OMA" id="CRFVAWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="233" mass="24848" checksum="5D58F721429D202D" modified="2017-01-18" version="1">MMGHSHAVSGAMLYAASAPFLPPLLLHTTLQPADILMGTVLCAGAALLPDLDHHDGSIANFLGPVSKALCRFVAWASGGHRHATHSLLFVALMGGGTWAGVTFLGRYFTLSVTFFLLALAIRALRLCPPSNGPEAWITVIGLAALGTFGMNTWMPNSPGWLPYAVGLGTLAHLLGDCLTKKGAPLLWPHKERYEIVLIKRSGNSVETKVLVPIMSVATFVLLWFTALSPQIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN3</accession>
    <name>A0A1E7NDN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553685.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000589.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7374"/>
    <dbReference type="EnsemblBacteria" id="ARF81189">
        <property type="protein sequence ID" value="ARF81189"/>
        <property type="gene ID" value="B6264_21845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38782">
        <property type="protein sequence ID" value="OEV38782"/>
        <property type="gene ID" value="HS99_0019110"/>
    </dbReference>
    <dbReference type="OMA" id="WSEAGPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="27495" checksum="1740F8A35592F9CA" modified="2017-01-18" version="1">MTVLLALSASLLTGLGDFGGGVLTRRLPALAVVVVSQAAATVALLLAALATGGWADASPALWYAVAAGVIGPFAMLAFYRALALGPMGVVSPLATVGVVVPVGVGLALGERPGFGQLAGIAVAVAGVVLAGGPERGGPSAARTALLLTLAAAFGFGANMSLLSQASAGGGLLLVLCVQRLVNVLVGGAALLTGPRGTDTRGLLPELRSRLPLLTGVGLVDVAGNATYALASHSGPAAVAAVLASLYPVVTALLARGVLKERLRPVQVVGAGLAVAGTLLLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ6</accession>
    <name>A0A1E7NEJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-E CRISPR-associated protein Cse2/CasB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4341"/>
    <dbReference type="EnsemblBacteria" id="OEV39136">
        <property type="protein sequence ID" value="OEV39136"/>
        <property type="gene ID" value="HS99_0017890"/>
    </dbReference>
    <dbReference type="OMA" id="WIEQICR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013382">
        <property type="entry name" value="CRISPR-assoc_prot_Cse2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038287">
        <property type="entry name" value="Cse2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09485">
        <property type="entry name" value="CRISPR_Cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02548">
        <property type="entry name" value="casB_cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="23045" checksum="E5AF8C72599FCE34" modified="2017-01-18" version="1">MRRGVGKDLDAVPFMHRFVASWLTDEQTRNRDVQRAYYTVASLIAAQRRDQYAAAKNQAQTKDDPAGGPDQDASGPQNDPGPAAAKRNPPRSLGHAFADGVLKGGQGSGLRETSAETRLNLLTRQSVDGLHRHLPGAVRQLRERDVEIDWARLLVDLCQWRRRSATIKRIWLQDYHRTLQKDGERRARDQDDHQADGADDTGSTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEM4</accession>
    <name>A0A1E7NEM4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate carboligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3467"/>
    <dbReference type="EnsemblBacteria" id="OEV39161">
        <property type="protein sequence ID" value="OEV39161"/>
        <property type="gene ID" value="HS99_0000035"/>
    </dbReference>
    <dbReference type="OMA" id="TLMGWGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009028">
        <property type="term" value="F:tartronate-semialdehyde synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006397">
        <property type="entry name" value="Glyox_carbo_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF14">
        <property type="entry name" value="PTHR18968:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01504">
        <property type="entry name" value="glyox_carbo_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="190"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="390"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="590" mass="63557" checksum="570296BCA44DAE21" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ6</accession>
    <name>A0A1E7NEQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285130.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3488"/>
    <dbReference type="EnsemblBacteria" id="OEV39179">
        <property type="protein sequence ID" value="OEV39179"/>
        <property type="gene ID" value="HS99_0000140"/>
    </dbReference>
    <dbReference type="OMA" id="ANHCVER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="418" mass="45770" checksum="1F5764C3F5BE9ECC" modified="2017-01-18" version="1">MTIRSTGQSWALDIALAQGGFDALHPEAVGTMEQLGHDHTDFAKVFALVRSGAMLPKAWATVAGQAEERAAHHERGGFAQTAADLYLRAAVMWGRAQYSIFDAADPRKAAMRAHANHCVERLGALRDGRVRRVVLDFEGSRIFALLHLPAGPVENAPAVILGPGMDMIKEDYIWAAERYYTSRGMVALSIEGPGQGESRAGGLTVDLGNYERAIGRYLDHLSSLPEVDAERIGMFGISMSGYWGSRAAATDRRLAALAAFEAVTGDFATIFERAQPTFKNNYMYMAGYTDEEAFDRDLAHRMPLGDLVADITCPVLYGIGEFDELTDLGQALESFERIRAPKELRVYEDEFHPLGGVAAEAFRFGAEWLERALGGEFADPGRDVRHYVHRDGRTTDGTADPSWWLGAAPSALGELRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ8</accession>
    <name>A0A1E7NEQ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557327.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83199">
        <property type="protein sequence ID" value="ARF83199"/>
        <property type="gene ID" value="B6264_30105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38973">
        <property type="protein sequence ID" value="OEV38973"/>
        <property type="gene ID" value="HS99_0017845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="10390" checksum="AB51EF87F913338C" modified="2017-01-18" version="1">MDDTQAIVDFLRDNYRHHIETRESIHNAVITGRIPAFDGDRRKHADITLQSVHEAQSMLELFETTIVAHLGTAGPMGAIAEQQLRILARPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX7</accession>
    <name>A0A1E7NEX7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">HS99_0000545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550183.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3573"/>
    <dbReference type="EnsemblBacteria" id="ARF82446">
        <property type="protein sequence ID" value="ARF82446"/>
        <property type="gene ID" value="B6264_29410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39247">
        <property type="protein sequence ID" value="OEV39247"/>
        <property type="gene ID" value="HS99_0000545"/>
    </dbReference>
    <dbReference type="OMA" id="MAIGKCE"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5033204789" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033204790" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="177"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="41048" checksum="20941E85E623A384" modified="2017-01-18" version="1">MQPAVPRGFRAVTTNMGLKDVEDDFAAVISEVPCRSAAVFTRSRFAGPSVVLSREAAALQHSRGMVVLSRNANVATGRTGAENAAEVRRRVAEIAGISPDELVIGSTGVIGRPYPMDGIRAGLDAMTWPFPEADYAAVARAIMTTDTRPKYLHVRCGDAVLVGIAKGVGMIEPNMATLLTFFFTDADVPAAELDALFRRVMDRTFNALSIDTDTSTSDTAAIFANGLAGAVDLPAFEQALYECALHLVRDIASDGEGASKLIEVRVTGARDTAQAKRVGKSVVNSPLVKAAVHGADPNWGRVTMAIGKLDDETDIDPAAVRIRFDDLPMYPEEPSDALLEQARTYLSGDEVVIRIDLGVADGAFTVYGCDLTEEYVKLNADYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL9</accession>
    <name>A0A1E7NFL9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556247.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39501">
        <property type="protein sequence ID" value="OEV39501"/>
        <property type="gene ID" value="HS99_0002075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9802" checksum="D12D4C25C2419CD1" modified="2017-01-18" version="1">MKLSEWSAWISLGLFWLDPAFWMSLASCHQLVPVPRMLWSPRPSIRPWPPSAARTASMPALAPATLISGRQPPLDEARVPQAGLPESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV6</accession>
    <name>A0A1E7NFV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000456.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5043"/>
    <dbReference type="EnsemblBacteria" id="OEV39515">
        <property type="protein sequence ID" value="OEV39515"/>
        <property type="gene ID" value="HS99_0002160"/>
    </dbReference>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17401" checksum="DFCC63EBAD26C3A0" modified="2017-01-18" version="1">MAAAGLSFDVVSIEKPDDVNVIIGQSHFIKTVEDLHEAMAGVGPHLRFGIAFCEASGACLVRRSGNDDELVPLAVRNAQAIGAGHSFVILLRGGYPVNVLNAVKLVPELCGVFCATANPVDVLLAVTDRGRGVIGVIDGVPPVGVETDEDAANRHRLLRQIGYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ6</accession>
    <name>A0A1E7NFZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386946.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000581.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2722"/>
    <dbReference type="EnsemblBacteria" id="OEV39592">
        <property type="protein sequence ID" value="OEV39592"/>
        <property type="gene ID" value="HS99_0002640"/>
    </dbReference>
    <dbReference type="OMA" id="KDVTACF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="16643" checksum="CD449042042393A5" modified="2017-01-18" version="1">MSRRSGVGWARRLPLGAGVRAGREWARRHLDTLGWNRDAPALADAVVLAVSELSTNAHVHAGSDAELVLTWDGRCLHLSVHDHSSRLPRPRAATPEATGGRGLALVDALADHWHTRLQKDGKTVTAYFHSPGAGQPGGWQCLSSSGSSNSSGPSSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA6</accession>
    <name>A0A1E7NGA6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550412.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2828"/>
    <dbReference type="EnsemblBacteria" id="OEV39678">
        <property type="protein sequence ID" value="OEV39678"/>
        <property type="gene ID" value="HS99_0003170"/>
    </dbReference>
    <dbReference type="OMA" id="YDWVTGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199127" evidence="2">
        <location>
            <begin position="30"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="42900" checksum="02942A0C24D61B64" modified="2017-01-18" version="1">MRISRIARTAAAATAAALLAAGCGSGGTAGSTSGHGGLNPPKLPMLQSLGPGEGQVNLVAWAGYAEDGSDDKSVDWVHPFEQQTGCKVNTKIAGTSDEMVSLMKTGQYDAVSASGDATLRLIAAGDVAPVNTALVQNYADVFDGLKNQPWNSVNGQMYGIPHGRGANLLMYRTDKVTPAPDSWSVVFDGASPYSGHVTAYDSPIYIADAALYLMRTRPELGIKNPYALDQDQLKAAVDLLKTQHKAIGEYWSDFQKSENSFKTGDTVVGTTWQVIANMAQTDHAPVKAVLPKEGATGWSDTWMVSAKAAHPNCAYQWMNWIVSPTANAQVAQWFGEAPANAKACDRTTDKDFCNTFHAADEAYWKDVHYWTTPVKSCLDGRTVACTDYAAWTAAWTEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC7</accession>
    <name>A0A1E7NGC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550476.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2900"/>
    <dbReference type="EnsemblBacteria" id="OEV39737">
        <property type="protein sequence ID" value="OEV39737"/>
        <property type="gene ID" value="HS99_0003525"/>
    </dbReference>
    <dbReference type="OMA" id="VALWRMP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41991" checksum="3A09735F1AA57ED4" modified="2017-01-18" version="1">MRPLFTWLMPTLIWAVVLWRAPSAFTTRANRALWAAFAAIALGLSCRPAFIERALGDVTGIRDVTQLLKHLAGVAAAYFLLEYVQAVRRRPDRPGAARARLLLTVAAGLALTLLFVFALPHDADGAFGIDAHFGEPGVKVYLCVFDTVFALASARATVLFWSNREAVPPGALRAGLTCLAASGATGLTYALYRYHFILTSGNATEFDADGKPVPLQDTLSEVLPALMLVLLVLGVTVPPARTLVGYLRDQYALWRLHPLWADVVAAVPQVVLGTPSSRLRDLLAVRDRSVELAHRAFAIRDAALVLREDAPVPGAGSAPGAASTVAADEDLARVEARWLRTAVRHRARHLPAPAPPSALAATTGGRTPREEIAWMLTVAAAYRQLGADEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG6</accession>
    <name>A0A1E7NGG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285049.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3575"/>
    <dbReference type="EnsemblBacteria" id="ARF83148">
        <property type="protein sequence ID" value="ARF83148"/>
        <property type="gene ID" value="B6264_29420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39796">
        <property type="protein sequence ID" value="OEV39796"/>
        <property type="gene ID" value="HS99_0000555"/>
    </dbReference>
    <dbReference type="OMA" id="WSCAVTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="15465" checksum="05B1DC33DDA8E659" modified="2017-01-18" version="1">MDGREPAARSDRGHRSVPHTADLRVEAWAPTAEGCIGELVHALVGSFADLSGARIVGERACTVLAVSDPDLLAGVLEEVIYRMDVDGELPAALALGPIGGLDGARSVEVRFRMADTATAALVGAVPKAVSLHGLELGEGPGGWTCAATVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI5</accession>
    <name>A0A1E7NGI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284974.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000389.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3614"/>
    <dbReference type="EnsemblBacteria" id="OEV39804">
        <property type="protein sequence ID" value="OEV39804"/>
        <property type="gene ID" value="HS99_0000745"/>
    </dbReference>
    <dbReference type="OMA" id="GTMYRVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199126" evidence="1">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28136" checksum="087D132F1A511FDC" modified="2017-01-18" version="1">MARKTRTSPRPPRRRRTRWLTALIATAVCAAVAGGVAAYRSVSDDASERPVTTEEAGRLALSRLNLYQASPVGVVLTADEGGGVRIRVEGVVDYRTHRGVGRYRSTGASGPLDHGLVVWDTDGLGLAPEPAGDQGPPWQQAEHIPRSGWSPRSYTADPLDAGLQLLTQVGADRPDNPLLLAQSGARWLGRDRIDGRGYDRFAGPRAQGAAPDGKTSPLTYWVDGDANLRRVTMRIAGLGTPTIVDFSGRNADAKLPEAPWLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ8</accession>
    <name>A0A1E7NGJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5069"/>
    <dbReference type="EnsemblBacteria" id="OEV39830">
        <property type="protein sequence ID" value="OEV39830"/>
        <property type="gene ID" value="HS99_0002030"/>
    </dbReference>
    <dbReference type="OMA" id="LYNFRAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199129" evidence="1">
        <location>
            <begin position="37"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="583"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="719"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="851"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="902" mass="95699" checksum="D9E418BA90B50EE2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK2</accession>
    <name>A0A1E7NGK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3676"/>
    <dbReference type="EnsemblBacteria" id="OEV39807">
        <property type="protein sequence ID" value="OEV39807"/>
        <property type="gene ID" value="HS99_0001035"/>
    </dbReference>
    <dbReference type="OMA" id="NPDDDTC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="474" mass="52014" checksum="8B0670E048E74879" modified="2017-01-18" version="1">MDFRFAAVSPHAVDIAGRCGAELLGRSVLETYPGVAGSELWHGYLSAYATGVRYEGELDYQEVAAGIPRLSRFKVRAVPTRQGLVVSWARLDTHERKQRRQALIQRLGKTGWMDHDLVRDEITWSQEVYAIFGRARSLGPVALHDLFVQAPADDRDQLEGELLQLVGRGERMDRTVRIVLPGGEVRHVRVVAEAQTDAHGDPVELQVLFQDLTAAKQYEQQLLEHQETVLAHQGLLAAERDLAARLQNTLLPVSQRVLHLAGLVIDVAYQPVQEGLNLGGDWYSAVELPDGSVLLVVGDVAGHGLDAVATMALLRFTAKGMAITGTPLPEILHRLNTLLLHASDRPYSTATMIMACYRPETSRLTWVQAGHLPPLLVRQGEARYLPPPAGILLGATDTPRYEESTVDLLPGDELLLYTDGLIENPGEPLDTALARLASAVPEHQGELPFLDGLVRALVGPAGRRDDICALHVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP4</accession>
    <name>A0A1E7NGP4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0003540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2904"/>
    <dbReference type="EnsemblBacteria" id="OEV39870">
        <property type="protein sequence ID" value="OEV39870"/>
        <property type="gene ID" value="HS99_0003540"/>
    </dbReference>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="8"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="443" mass="47189" checksum="1F1263D1E2ABC9C4" modified="2017-01-18" version="1">MAHRLVEALATDADSVVKRLRATFRSGRTKPLDWRLDQLRALRTLLTEQSEAFLAALNADLGKGATEAYRTEIAFTLNELDHTVRHLEEWLRPKPAAVPDAFLPAQARVVRDPLGVVLIIAPWNYPLQLALAPLVGALAAGNTAVVKPSELAPATSAAIARLLPRYLDRQAVAVVEGAVPETSALLEQRFDHIFYTGNGAVGRIVMAAAAKHLTPVTLELGGKSPVVVEPGVDLAVTAQRIARGKFLNAGQTCVAPDYVLAVGDTAPALAAELAAAVRAAHGDDPAGDPEYGRIVNERHFDRLTALLGEGRVVTGASHDRATRYLAPTVLADVPPAAPVMQEEIFGPILPIITVPDLDAAIAFINERDKPLALYAFTDSDRTKQRLAEETSSGALVFGLPVSHLAVPELPFGGVGESGMGRYHGEYSIDTFSHAKAVLDKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV24</accession>
    <name>A0A1E7MV24_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279675.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000133.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2986"/>
    <dbReference type="EnsemblBacteria" id="OEV32280">
        <property type="protein sequence ID" value="OEV32280"/>
        <property type="gene ID" value="HS99_0016320"/>
    </dbReference>
    <dbReference type="OMA" id="MWDFPGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="20221" checksum="74401D197A8132F9" modified="2017-01-18" version="1">MEFLCYHRDRPDSLALRRELLEEHWSYMDRFAEELIARGPTLDDDGVPTGSVHIVDLPDPAAAPAFAFDEPGYRAGVYRDVLLRRWRNLLGRTMWDFPGGETGGNHYLVLGLGTGQPSDLTVPADRDELIAYGPLLSDDGVTWPGTAVLLRAPDLKTARGVLTVERYADVEVHGWTFGGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK1</accession>
    <name>A0A1E7MVK1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0017425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000414.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1210"/>
    <dbReference type="EnsemblBacteria" id="OEV32461">
        <property type="protein sequence ID" value="OEV32461"/>
        <property type="gene ID" value="HS99_0017425"/>
    </dbReference>
    <dbReference type="OMA" id="IAQTCIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="49126" checksum="E7B6D5A1CBFBD1A3" modified="2017-01-18" version="1">MSQTIDNAPYTAFHRRLALACSGGPLLDGYILSIVGVALIGMRPDLGLSTAQVSLIGAAALVGMFVGGALFGVLTDKIGREVMYTADLLVMVACSVLSFWVDSVWAIAVLRFVLGMAVAADYPIATSLLAEWLPAKHRGRLLGQQIVAWYAGSVLAYVVGYLFLELAGPGSWRWMLASSTVLCVVFLVIRRGSPESPRWLAANGRVGDAVRVVEKHLGVRVDGRELMPDPAERARRSSGLRLLMTPPYRRRTLFCGLFFLCQVGPLFAMLTFGPQILSSFGMPGGTVMETLGTGLISLVFLLGCYPALRLVDTKGRRPVIVWSFALMTVPLALLGVWPTAPAAVALTALCAYAFLCGGPNVLDWTYPNELFPTEIRATAVGVATSVSRIGAAVGTYLLPLSLTGLGTGPTMLIAAGTTALGLLVCVLWAEETRGTALGAAPVAGRTGTAKTSAVPAQRVPQTARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVN2</accession>
    <name>A0A1E7MVN2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6295"/>
    <dbReference type="EnsemblBacteria" id="OEV32491">
        <property type="protein sequence ID" value="OEV32491"/>
        <property type="gene ID" value="HS99_0017590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="176"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="43461" checksum="99A86AAC7F9E62E1" modified="2017-01-18" version="1">MTCDDAVLGGALAGLLTGSRTSGPAELPALVHEAARALGTDGARVLLADVQQHSLVPLPGPEPGEDGHRVDIEGTLGGRAYRLQQTQLSAGPPPTGWFPLVDGVERIGVLRIEGVEGAALDRHTIECCEALAGLVALVVASKSAYSDVIVEAVRRQRMSLQAELLWAFLPPRTIGTRDVTSSAVLEPAYDVGGDAFDHAVAHGHLHVSVFDAMGHDLASGGASSVALAACRSTRRSGGGLADIARTIDRTLARWIPDRLLTAVIADLDTATGELSWVNCGHPPPLLIRDARVVPDALRRRPELPLGLGFHEHGPQPVHHARLQPGDRLLVYTDGVTEARSAAGELFGEHRLTDTLVHHMAGGDPAPEALRRLVHALLTHQDHQLRDDATIALAEWHPRRHGSGRTVSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS8</accession>
    <name>A0A1E7MVS8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32531">
        <property type="protein sequence ID" value="OEV32531"/>
        <property type="gene ID" value="HS99_0017300"/>
    </dbReference>
    <dbReference type="OMA" id="SKWGYTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="32"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="33037" checksum="6B74A48369272A96" modified="2017-01-18" version="1">MGLGTAAVGRPGYITLGRADDLPAERTVEALRERTHALLDAAYAAGVRYLDTARSYGRAEEFLAQWLAEHPEAAAEVTVGSKWGYTYTADWRTSGVAAHEVKEHSTAVYDRQIRETRALLGPHLDVYLVHSVTADSPALTDPALHRRLAGLAAEGVRVGLSTSGPAQAEAIRRALAVTVDGRPLFTAVQATWNLLETSAAPALAEAHRAGWLVVVKEGMANGRLAGRNATGPDTAALRTLAARTATAPDALALAAAAAQPWADVVLSGAATLDQLTSNLAAAEVVLGPEDLAPLAAMAEPAEDYWRTRSSLPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT5</accession>
    <name>A0A1E7MVT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000633.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1237"/>
    <dbReference type="EnsemblBacteria" id="OEV32535">
        <property type="protein sequence ID" value="OEV32535"/>
        <property type="gene ID" value="HS99_0017570"/>
    </dbReference>
    <dbReference type="OMA" id="QWLDIGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="30368" checksum="C407C6857D89E3A3" modified="2017-01-18" version="1">MTVTDPDPAEPAGPQIRQDIPHSARMYDYFLGGKDNFAVDREAAERVLTAFPTMRTAVRANRTFMHRATRALARRGLSQWLDIGTGIPTSPNLHEVAQAVEPRARVVYADNDPVVLAHSRALMTSTPQGRTAYVHGDVRDPASILTTPQVAETLDLTRPVVLSMVALLHFVPDLDDARAIVEHLLNPLPAGSALVLSHATAELDPPGASKVEEIYNQAGTSLRLRSRAEFATLFEGLDLLDPGIVPAHRWHPDGTDGAADLLPATVTDAQVSFYAGVALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU2</accession>
    <name>A0A1E7MVU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000095">
        <property type="protein sequence ID" value="OEV32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366748.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene100"/>
    <dbReference type="EnsemblBacteria" id="ARF80105">
        <property type="protein sequence ID" value="ARF80105"/>
        <property type="gene ID" value="B6264_15325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32544">
        <property type="protein sequence ID" value="OEV32544"/>
        <property type="gene ID" value="HS99_0040245"/>
    </dbReference>
    <dbReference type="OMA" id="ADPWVPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16348" checksum="DC46D444A3D4B5A9" modified="2017-01-18" version="1">MSLVTALVYRRRHRLLGRLVQEALALYGMEVPAACEIGPGLTVFHRGFGTVLHPYTTLGADVTLYNGVTIGRADPWVPQERSAMRRVVVEDGAVLCAGAKVVCKEGVLTVGAGTVVGANAVLTRSTGPGEVWAGVPARKVGMRERDWAPPVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW70</accession>
    <name>A0A1E7MW70_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein A</fullName>
            <shortName evidence="1">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrA</name>
        <name evidence="3" type="ORF">HS99_0015520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3168"/>
    <dbReference type="EnsemblBacteria" id="ARF78284">
        <property type="protein sequence ID" value="ARF78284"/>
        <property type="gene ID" value="B6264_04565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32678">
        <property type="protein sequence ID" value="OEV32678"/>
        <property type="gene ID" value="HS99_0015520"/>
    </dbReference>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0228">DNA excision</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0742">SOS response</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <begin position="645"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="970" mass="106986" checksum="D05200C1CCCC7FF9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW79</accession>
    <name>A0A1E7MW79_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">HS99_0015600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288303.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3184"/>
    <dbReference type="EnsemblBacteria" id="ARF78270">
        <property type="protein sequence ID" value="ARF78270"/>
        <property type="gene ID" value="B6264_04485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32692">
        <property type="protein sequence ID" value="OEV32692"/>
        <property type="gene ID" value="HS99_0015600"/>
    </dbReference>
    <dbReference type="OMA" id="QFFWQFP"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="34140" checksum="3EDD3C2C6D10CC42" modified="2017-01-18" version="1">MLVTAVETRPAGVTGATPAHRPIGARVGAFVALTKPRIIELLLMSTVPVMFLAQQGVPNMLLVLKVVVGGYLSAGGANALNMYIDRDIDALMSRTERRPIVTGMVSPREALVFGITLGVLSTLLLGFGVNWLSAGLALGALLFYVFVYTLGLKRRTSQNIVWGGIAGCMPVLIGWSSVTNSVSWAAVALFLVVFFWTPPHTWVLSMKVRDDYERAGVPMLPVIKGNVAVGKQVVAYSWVMVAVSLAVWPLGHMSWLYPVAAVLLGGFWLREAHALYGRAKAGIVGAKLKEMRLFHWSITYLSLLFVVCAIDPFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG9</accession>
    <name>A0A1E7MWG9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287875.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000335.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3845"/>
    <dbReference type="EnsemblBacteria" id="ARF78335">
        <property type="protein sequence ID" value="ARF78335"/>
        <property type="gene ID" value="B6264_04855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32785">
        <property type="protein sequence ID" value="OEV32785"/>
        <property type="gene ID" value="HS99_0015225"/>
    </dbReference>
    <dbReference type="OMA" id="VYFDAGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="39419" checksum="DDD0DA74DFF585E6" modified="2017-01-18" version="1">MPTELAEAYLTLLADVSRTGRLLRRDELEGLRRLGEQCAEAGYGLREVVSHCLAAARRAWQTLPGTTGATSVGELRRMGDAVLAATDAALAALGEGHERSQRLAVRQEEAARREFIDDLLHGRSDLGLLAERAERFGLRLAGAYTVAVAVGDEPFADVHPMVHRVERELAGRFGERDVLLAGKDGRLVCIAPDSERAVLDAFADLTLRPGPGYRPVLRVATGRRHSGASGVLRSYDEALDALDYAQRLGLPACRLKAEDLLVFPVLMRDRAAMADLVRSVLGPLTEARGGARPLLDTIAVQAEAAYVNAEAARRLGLSVRTLGYRLERIKSLTGYDPADALQRFTLETAAMGARLLNWPEQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV4</accession>
    <name>A0A1E7MWV4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552580.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5788"/>
    <dbReference type="EnsemblBacteria" id="ARF81336">
        <property type="protein sequence ID" value="ARF81336"/>
        <property type="gene ID" value="B6264_22680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32926">
        <property type="protein sequence ID" value="OEV32926"/>
        <property type="gene ID" value="HS99_0013660"/>
    </dbReference>
    <dbReference type="OMA" id="FTRQGQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="31880" checksum="F51A566290BAAB95" modified="2017-01-18" version="1">MDLNLLRALDALLQENSVTRAAERLGTSPAAVSRTLARLRRAVGDPLLVRAGQGLVPTPRALELREEVAELLRGCDNLLRPGAGFDPAHLERTFTVQAGDAVLVRVAGPLTERIRAEAPGVDVVFLPEAMEGGPALRQGVVDVEVGVLGQLDPEVRTRPLVTVTVVGVARSGHPLFEGRITARRFAAADHIGVSRRGRRHGPIDTALADRGLRRRVAVVVPSHTGAMLLARDSDLVTLGPSDWLPRTFEALGLRTFPIPLELPPLELGMAWHPRNSADPGQRWFRTHLAAAVRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX39</accession>
    <name>A0A1E7MX39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552496.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5726"/>
    <dbReference type="EnsemblBacteria" id="ARF81395">
        <property type="protein sequence ID" value="ARF81395"/>
        <property type="gene ID" value="B6264_23000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32981">
        <property type="protein sequence ID" value="OEV32981"/>
        <property type="gene ID" value="HS99_0013970"/>
    </dbReference>
    <dbReference type="OMA" id="YDLDHYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="24950" checksum="43C2B7A54CFB84E8" modified="2017-01-18" version="1">MNEQPLRVVVADDQALVRIGFRLILESEGIEVVAEAEDGEQAVAAVRRSRPDVVLMDIRMPGLDGLEATRRILAGGPENAPRIIMLTTFDLDHYVYAAMAAGASGFLLKDVTPEHLAAAVRLVRTGDALLAPAITRRLVERFARPAAPHAAAPHRELATLTPRELEVMSLLARGLSNAELAARLQLSEATVKTHVARILGKLGLRDRAQVVVAAYETGLVSAGTPGTPGRPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX68</accession>
    <name>A0A1E7MX68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gualylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552446.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81449">
        <property type="protein sequence ID" value="ARF81449"/>
        <property type="gene ID" value="B6264_23290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33032">
        <property type="protein sequence ID" value="OEV33032"/>
        <property type="gene ID" value="HS99_0014260"/>
    </dbReference>
    <dbReference type="OMA" id="IHERAGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="DUF4242"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="DUF4242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8824" checksum="C63A94C6A9BA9AAD" modified="2017-01-18" version="1">MKFMDVHRGMTGITAEQFRAAHAADAAIEGEEGVHFEHAWADPESGTVYCLSEAPSRDAVQRVHERTGHPADEIHSVPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS0</accession>
    <name>A0A1E7MXS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386384.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7101"/>
    <dbReference type="EnsemblBacteria" id="OEV33219">
        <property type="protein sequence ID" value="OEV33219"/>
        <property type="gene ID" value="HS99_0039220"/>
    </dbReference>
    <dbReference type="OMA" id="GIHCSTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="37620" checksum="5E3492689B552055" modified="2017-01-18" version="1">MSHHRRSAEAHPRVPADDVPHARTWMSWPSRRGVWGLRLGGVQEDIALIARTIAQFEPVVMCAPDDWTADKARARCGPAVEVITAIPTDDLWMRDIAPVFRRDGYGGLEAVVLNFNGWGNKQVHHDDARVAERLAAHRGLRHSFADFTGEGGAIETDGDGTVMATESSLVNRNRNRGMSRDEIEDAVLAAYGADRMIWLPGIEGKDITDDHVDVTSRFVRPGVVMVQLPPADRNDAWARDAREQFAVLSAATDARGRRLHVIVVHGPDSVRSRSSEFVDSYLNFHLVNGGVITAQFGDPYKDTAARDTLAAAFPGRTVVQLDVDRLMAGGGGIHCSTMHEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT5</accession>
    <name>A0A1E7MXT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretion protein Rhs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557607.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000088.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7109"/>
    <dbReference type="EnsemblBacteria" id="OEV33224">
        <property type="protein sequence ID" value="OEV33224"/>
        <property type="gene ID" value="HS99_0039255"/>
    </dbReference>
    <dbReference type="OMA" id="AFSGRYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="388"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="592" mass="61495" checksum="A06AF3F584E90AF7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY20</accession>
    <name>A0A1E7MY20_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">HS99_0012010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7025"/>
    <dbReference type="EnsemblBacteria" id="ARF80420">
        <property type="protein sequence ID" value="ARF80420"/>
        <property type="gene ID" value="B6264_17240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33319">
        <property type="protein sequence ID" value="OEV33319"/>
        <property type="gene ID" value="HS99_0012010"/>
    </dbReference>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="12"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="44162" checksum="B58C89BC9A09A66E" modified="2017-01-18" version="1">MTSDLTTADSPVLAVARRAREAAAALAPLPRRAKDAALLAIADALVARSAEIVAANAEDVARAREAGTAESVIDRLSLTDERIAAIASDVRDVAGLADPVGEVVRGYTLPNGLDVRQVRVPLGVVGIIYEARPNVTVDAAALCLKSGNAVLLRGSASAYRSNTALVAVLRDAVEAAGLPADVIQLVPGESRDSVQELMRARGYVDVLIPRGGASLIRTVVEGSTVPVIETGTGNCHVYVDAQTDLAMAVGILLNSKAQRVSVCNAAETLLVHQDVADAFLPLALAALAEAGVTVHGDEAVLKAAEGSAATVVPATDEDWGAEYLSYDLAAAVVPSLDAAVEHIRRWSSGHTEAIVTTSQAAARRFTQLVDSTTVAVNASTRFTDGGEFGFGAEIGISTQKLHARGPMGLPELTSTKYIVTGDGHVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA7</accession>
    <name>A0A1E7MYA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287558.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3968"/>
    <dbReference type="EnsemblBacteria" id="ARF80520">
        <property type="protein sequence ID" value="ARF80520"/>
        <property type="gene ID" value="B6264_17835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33416">
        <property type="protein sequence ID" value="OEV33416"/>
        <property type="gene ID" value="HS99_0012610"/>
    </dbReference>
    <dbReference type="OMA" id="VDATRWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35953" checksum="A04F9212AD51B8AF" modified="2017-01-18" version="1">MKADRLLSILLLLQTRGRVPATELAERLEVSVRTIYRDVESLSAAGVPVFTERGRHGGINLLPGYRTDVTGLTADEARALFVLSTQGAHSDLGLDGALGSALRKVMAALPAPHRPAAERVSERILVDPARWMQNSQPGAAGLPDLGELQYAVFADRRLRLRYRHSGTPAPVEYTVDPYGLVNKATVWYLVADLHGEPRLFRADRVLSAETTEETVRRRAGVALGEVWAALREQVERLPKDVPARVRVRRGRLDLFLRLHGGRVTAPPPESGAGPAEEWVELALAFPAAAAVRALLAFGADVEVLAPPAARRELARAAAEALRLYRDEDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ46</accession>
    <name>A0A1E7MZ46_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1925"/>
    <dbReference type="EnsemblBacteria" id="OEV33725">
        <property type="protein sequence ID" value="OEV33725"/>
        <property type="gene ID" value="HS99_0038210"/>
    </dbReference>
    <dbReference type="OMA" id="QVIPIME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="12845" checksum="4F5A7FF5ECFA7FCC" modified="2017-01-18" version="1">MRATTTVVDGQAVIVRLDGEVDLEDRQPLQQALARVMQTRPPQLIVDLTGLAFCHSVCLNALLTARRRAKAAGVEMVLAAPPPQTRRVLEITGTDQVFTICSSVRTALADTYAASRQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD9</accession>
    <name>A0A1E7MZD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366787.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4513"/>
    <dbReference type="EnsemblBacteria" id="ARF80372">
        <property type="protein sequence ID" value="ARF80372"/>
        <property type="gene ID" value="B6264_16960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33794">
        <property type="protein sequence ID" value="OEV33794"/>
        <property type="gene ID" value="HS99_0037590"/>
    </dbReference>
    <dbReference type="OMA" id="GFRIGCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="49791" checksum="3D4B3F5BED82F0E9" modified="2017-01-18" version="1">MNRDAAAPAGPAPLRTRGAPGPDRPPVPRPTVEELRLTAFKSYRRAVLPLAPLTVLHGPAGVGKSNALDALAVLSRLALGEEITGSLNGLPGRTGPLATPVRGGLDGCVPHGRDAVILGCTVRSPRGRIRLDLVIRTDGTVRIARESLSLDGRILVDTGEQDVRNGRVNVCWHNDTRQGDIRAPLPSGTMISAQLPLRVAGSSTGERLVLAAVEDLLTALREVFPLHPVPALMRGWAKADPQARLRSNAGNISAVINRLAHECPRRYGQLLRAVQAAAPHPLLGLTLAEREGGRRVLAVFDEGVLGRTGADQASDGMLRHLAFAAVLLTGAGVLDLDVAAEVPWAHRQLTVLAEDLGAGLATEQAASLLRLARDMAGRNQLRVVAALQEPGAAREAFGAAGESAGEVVLVECRRDPATGVTVLRPEAARVPVQGGRGEEGSAARGGASGVGGSAAAGGSAGVGRSGAAGGGGGPVVGDGDAVDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG1</accession>
    <name>A0A1E7MZG1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4522"/>
    <dbReference type="EnsemblBacteria" id="ARF80380">
        <property type="protein sequence ID" value="ARF80380"/>
        <property type="gene ID" value="B6264_17010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33801">
        <property type="protein sequence ID" value="OEV33801"/>
        <property type="gene ID" value="HS99_0037635"/>
    </dbReference>
    <dbReference type="OMA" id="AGPHYQN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="SSF49329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18319" checksum="045EEF6D969085A1" modified="2017-01-18" version="1">MPAPFAAALLPLALLAPAASPVSVTETAFDPATAFVRPTAISYAQDLVPYGSHARVVTDRSVPGRTVLTLTVSGLAPDHEFPVHLHTGDCGADPAASGPHYQDVVDPVQPSTDPAYANDRNELRLVLRTGGRGGGTARAAVDWQPRPGEARSLVLHAGTPAGPHAAGDRVACIRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ4</accession>
    <name>A0A1E7MZJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033355070.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80318">
        <property type="protein sequence ID" value="ARF80318"/>
        <property type="gene ID" value="B6264_16645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33841">
        <property type="protein sequence ID" value="OEV33841"/>
        <property type="gene ID" value="HS99_0037525"/>
    </dbReference>
    <dbReference type="OMA" id="PARYIKQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014543">
        <property type="entry name" value="UCP028291"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09981">
        <property type="entry name" value="DUF2218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="12347" checksum="423772EBD43B4947" modified="2017-01-18" version="1">MPVSTARVATDRAARYAKQLAAHMSRRIETSFSPETGHGTLVFRAGTATLEAQSDALLLTVEGERDKLPELEDVVGRHLVRFGARDELVVEWHRDNGEAGLVHRNDEDAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZZ5</accession>
    <name>A0A1E7MZZ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280164.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2256"/>
    <dbReference type="EnsemblBacteria" id="ARF77872">
        <property type="protein sequence ID" value="ARF77872"/>
        <property type="gene ID" value="B6264_02085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34017">
        <property type="protein sequence ID" value="OEV34017"/>
        <property type="gene ID" value="HS99_0011240"/>
    </dbReference>
    <dbReference type="OMA" id="DERARMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13828" checksum="D8429F261312CBEE" modified="2017-01-18" version="1">MRIGELARRTGVTPRALRYYEEQGLLTPERRPSGYREYGDRDVDAVHGIRTLLAAGLNSAAIAEILPGLPLPGQRQAGPTCPELLDGLARERARITRQMDELAAARAILDAIMGAEAPSEVIRTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N068</accession>
    <name>A0A1E7N068_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2328"/>
    <dbReference type="EnsemblBacteria" id="OEV34074">
        <property type="protein sequence ID" value="OEV34074"/>
        <property type="gene ID" value="HS99_0011585"/>
    </dbReference>
    <dbReference type="OMA" id="DETADYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="33738" checksum="E42C33E9FEE1DDE8" modified="2017-01-18" version="1">MRLRAVVEGEERRFALWDLASLVEGGLGEVVDPDALTPRAERGWREQLGESGREWPGGELYRRRYWILGERDAVAGTVAVDNWTKGPSQLAVSSLYLRPHARGRGLAAAALDEVYAAATAEGLPGFRLEAHWSWQPAVRYYLRRGLWVVGWKRSLSFARMPQLPLHRVREEDGRLLLLVADRQRGWVPILAAGQEGRWLRLDETADYRGCDGWVHEYARSTLALYLALAGRPLVRGPQWWAEAWRWADAGEPEGLAARIEEFERAARSRAGRTVVSPYRPVMLPEPAPPAFPQLADSGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K6</accession>
    <name>A0A1E7N0K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HNH nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554566.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6042"/>
    <dbReference type="EnsemblBacteria" id="ARF78135">
        <property type="protein sequence ID" value="ARF78135"/>
        <property type="gene ID" value="B6264_03700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34219">
        <property type="protein sequence ID" value="OEV34219"/>
        <property type="gene ID" value="HS99_0036800"/>
    </dbReference>
    <dbReference type="OMA" id="QDTWLNT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19549" checksum="B5A79F73DEACD2BF" modified="2017-01-18" version="1">MRNTLVLNASYEPLTTVSLQRAVVLVLQDKAVVEQAHPLRSIRGTGVAVPVPRVIRLQRYVRVPFRQQAPWSRRGVLARDQHLCAYCGRRATTVDHLQPRSRGGEDSWMNTVAACAEDNQRKADRTPEQAGMKLLRRPFVPTPQATLMLALGLRGSEARELADWLPAVPAQPVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V8</accession>
    <name>A0A1E7N0V8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551333.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000251.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6408"/>
    <dbReference type="EnsemblBacteria" id="ARF78725">
        <property type="protein sequence ID" value="ARF78725"/>
        <property type="gene ID" value="B6264_07155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34328">
        <property type="protein sequence ID" value="OEV34328"/>
        <property type="gene ID" value="HS99_0036380"/>
    </dbReference>
    <dbReference type="OMA" id="AEDVTMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="641" mass="69371" checksum="EE25352EFAA8A5AB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N154</accession>
    <name>A0A1E7N154_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289798.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1402"/>
    <dbReference type="EnsemblBacteria" id="ARF79247">
        <property type="protein sequence ID" value="ARF79247"/>
        <property type="gene ID" value="B6264_10260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34429">
        <property type="protein sequence ID" value="OEV34429"/>
        <property type="gene ID" value="HS99_0036080"/>
    </dbReference>
    <dbReference type="OMA" id="LARTECL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="36066" checksum="EC01EE6F2F9F31BB" modified="2017-01-18" version="1">MTRGIDDAAQAVYRLMLTDHQLDVEGLAGKLGLTEDQVRAALDQLAGLRLLRPCEDDAPGEPSGALRPVDPRVGLPALLRYYESVQQRAQLEFERRQAEISGMLAQFRDESAREDSQLERLLGMATVQARMEELVGSVRDELLTFSPGGAQSAASLQASRPDNEALLARGVTMRTVYLDSVRKDRATVQHAEWLTGLGCEVRTVPALPLRMLVIDRGVALVPIDPANTLKGAVQISSPGVLAALVSLFEQTWSDATPFGAPRERDEEGLTRQEQELLRLLGQGYTDEAAGKHLGVSLRTTRRMMADLMDRLGARSRFEAGLLAGRRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N189</accession>
    <name>A0A1E7N189_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="7" type="ORF">HS99_0035650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290678.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1074"/>
    <dbReference type="EnsemblBacteria" id="ARF78961">
        <property type="protein sequence ID" value="ARF78961"/>
        <property type="gene ID" value="B6264_08545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34442">
        <property type="protein sequence ID" value="OEV34442"/>
        <property type="gene ID" value="HS99_0035650"/>
    </dbReference>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="20426" checksum="F6678AA16FB3318C" modified="2017-01-18" version="1">MSEIRLAAETRTEFGKGAARRARRAGFVPGVVYGHGHAPVHLNLPGHDLMMALKTPNALLVVPIEGKDEYVLPKAVQREAIKRTIEHVDLLLVKRGEKVTVEIPVHTEGELAPGGNLLEHVLQALPVEAEATHLPEAVTVSVEGLEAGASVHAKDIALPAGVSLAVDADAVVLQVIAAQAAPVEDEAAEAEGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G8</accession>
    <name>A0A1E7N1G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0035585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278995.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2565"/>
    <dbReference type="EnsemblBacteria" id="OEV34521">
        <property type="protein sequence ID" value="OEV34521"/>
        <property type="gene ID" value="HS99_0035585"/>
    </dbReference>
    <dbReference type="OMA" id="IRDDQPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198750" evidence="3">
        <location>
            <begin position="23"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="UDPGT" evidence="4">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="41637" checksum="2BD02BAB525A1833" modified="2017-01-18" version="1">MSRVLFVVPPLVGHVNPTVGVAAELAARGHTVAWAGLPELVRPLAGPAAEVFPCAVAPGAEPGSAVRRPPELRGTAALKFLWEDFLVPLAEAMAPGVAAAVTDFEPDLLVVDQQALAGPLVAERLGLPWATSATTSAEFTGALDGMPLVEAWISGLLTDLRHRLGDPAGAADPRFSPHLVLAFTTAELAGPQADRQVCFVGPSIAGRPASTAFPWEWLDPDRATVLVTLGTANTDVGAAFLADGQTALRARSDRLQAVIVDPGCVLGEPAADPDVLVLPFVPQLQLLAHCSAVVCHAGHNTVCEALWHGVPLVVAPIRDDQPVVAGQVVAAGAGVRVRFGRSSADRLGQAVDMVLDDPGHRAAARRIAASFRAAGGAARAATQVERLLREVPQPSERRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J4</accession>
    <name>A0A1E7N1J4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0035310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5566"/>
    <dbReference type="EnsemblBacteria" id="ARF79351">
        <property type="protein sequence ID" value="ARF79351"/>
        <property type="gene ID" value="B6264_10840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34559">
        <property type="protein sequence ID" value="OEV34559"/>
        <property type="gene ID" value="HS99_0035310"/>
    </dbReference>
    <dbReference type="OMA" id="IEFARMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="609" mass="66741" checksum="039EFB4365BE5BD3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N253</accession>
    <name>A0A1E7N253_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555823.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4594"/>
    <dbReference type="EnsemblBacteria" id="ARF81876">
        <property type="protein sequence ID" value="ARF81876"/>
        <property type="gene ID" value="B6264_25970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34762">
        <property type="protein sequence ID" value="OEV34762"/>
        <property type="gene ID" value="HS99_0009790"/>
    </dbReference>
    <dbReference type="OMA" id="HINAIFD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23652" checksum="9AA8EA6F95FD9D0D" modified="2017-01-18" version="1">MRLMIAEDSALLRVGLERLLLDEGHEVSAAVGDADALLAAVAAEPPDVVVIDVRMPPSHTDEGLRAALRLRYEHPAVGVLVLSQYVEQRYAAELLAADTRGVGYLLKDRVARVEEFLSALERVHGGDTVFDPEVVRRLLARTRHTDDLELLTERERTVLTLMAQGCTNAAIAQQLFVSRSAVEKHVNAVFDKLRLPRDEGSNRRVLAVLRFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N257</accession>
    <name>A0A1E7N257_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0009820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555813.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4588"/>
    <dbReference type="EnsemblBacteria" id="ARF81870">
        <property type="protein sequence ID" value="ARF81870"/>
        <property type="gene ID" value="B6264_25935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34767">
        <property type="protein sequence ID" value="OEV34767"/>
        <property type="gene ID" value="HS99_0009820"/>
    </dbReference>
    <dbReference type="OMA" id="VSPLVVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32773" checksum="C34F18997BD2F789" modified="2017-01-18" version="1">MPLRPITVLGESAADAFPGGSTPDGGLALRVLPGGGPANTAVALARLGTPTRFLGRISTDPFGQLFRARLAASGVDLTGCVNTAEPSTLAVATLDEQAQATWTFYAEGTADWQWTTDELTATRTTETACLHTGSLALVRDPGGQRIEQHLAWVREHATVSIDPNVRPLLVPPADYRERLDQWCALADILRLSEEDLAVLLPGASPADACHRWHEAGARLVVVTLGERGAYAPLDGHPVTVPAPPTSVVDTVGAGDSFTAGLLHRLNQLDLLGSRLDSLTQNAVADACRFAVRVAALTCSVVGANPPSAESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H6</accession>
    <name>A0A1E7N2H6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555918.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83083">
        <property type="protein sequence ID" value="ARF83083"/>
        <property type="gene ID" value="B6264_26225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34880">
        <property type="protein sequence ID" value="OEV34880"/>
        <property type="gene ID" value="HS99_0009550"/>
    </dbReference>
    <dbReference type="OMA" id="VEEIHTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16210" checksum="8B2E15FEFC2AA7F4" modified="2017-01-18" version="1">MDDIDRRLLTLLQQDAGLSYAALGKAVGLSAGATHERVRKLRDRGVIRRTTVEVDPGALGLGVLAFVMVESSAWIGDSAAAFAAIPEIEEAHIIAGSASVFVKVRTATTEQLQDVLRRLYAIDGVSGTQATVSLETFFERPPSPAPQNPPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I9</accession>
    <name>A0A1E7N2I9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7608"/>
    <dbReference type="EnsemblBacteria" id="OEV34896">
        <property type="protein sequence ID" value="OEV34896"/>
        <property type="gene ID" value="HS99_0010315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14315" checksum="36B4E7EC59D7AAB6" modified="2017-01-18" version="1">MTKAVSIRRPVAEVFAFLADPANWPAWAVVNVKAVEPTDDPDWWLMTTPRGPARLRIRGNAALGILDHDYVEDQASWQVPARVVANGTGAEFMITFFQPPTFTDAFFDEQIALVDTELATLKRILETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2K5</accession>
    <name>A0A1E7N2K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557768.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83066">
        <property type="protein sequence ID" value="ARF83066"/>
        <property type="gene ID" value="B6264_25500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34895">
        <property type="protein sequence ID" value="OEV34895"/>
        <property type="gene ID" value="HS99_0010225"/>
    </dbReference>
    <dbReference type="OMA" id="KVVEYHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10926" checksum="595B6DC863A1DED6" modified="2017-01-18" version="1">MFILELTYTAPLDRIEAAHPEHVAWLDSHYESGVFIASGPKDPRDGAVIVAVGADRAQIEDIAKGDPYSVAGLAEYTITNFRAMRTSPALEEYRHQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T2</accession>
    <name>A0A1E7N2T2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4593"/>
    <dbReference type="EnsemblBacteria" id="OEV34763">
        <property type="protein sequence ID" value="OEV34763"/>
        <property type="gene ID" value="HS99_0009795"/>
    </dbReference>
    <dbReference type="OMA" id="RECFGPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198698" description="HATPase_c domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="273"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="38021" checksum="7F8B4DB0B335A8F5" modified="2017-01-18" version="1">MRAARAAAGIALGALTALATPALLATAALTRCARLPLRLAALEQRRVSALLGGPEPAPEGVEARRAAAYLWCRVPVGLAGGGALLLLAAGAWTAASGLARWLAGHDADGMGPSWPVAGYLLTAGLLLLFLDLAGLAAVADLERRLAHRFLGPDELALMRRRIDELAASRSGIVEAVDAERRRIERDLHDGLQQRLIVVAMLLGRGRRKNSEELYRQAQAEAEQALEELRQVAWRAYPASLDQLGLREALAVDAERSPIPVHISGDLARRPAPAVETAAYFAVREALTNAAKHAGATRIEVAIGQDTSLVRVSVHDDGRGGADPTGPGLSGLQRRIAALDGRLRVDSPPGGPTHVVAELPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T4</accession>
    <name>A0A1E7N2T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7679"/>
    <dbReference type="EnsemblBacteria" id="OEV34992">
        <property type="protein sequence ID" value="OEV34992"/>
        <property type="gene ID" value="HS99_0034635"/>
    </dbReference>
    <dbReference type="OMA" id="HIGRWNP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="20056" checksum="EB1BE845E9E3EAAE" modified="2017-01-18" version="1">MSDDVGMRVMIRAPRAEDEVLYAEAVRRSAEHIGRWNPVEPDGLPELLGRQGAGLRTFLIFDRDTGGLVGKVNVANIVMGRFCNATLGYDSYLPYAGTGRMTEGLRLVLDRCFAPQSADGLGLHRLEINVQPENERSIALAKRLGFRHEGFTPRMLFLQGDWRDHERFALTAEEWPGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2W6</accession>
    <name>A0A1E7N2W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4695"/>
    <dbReference type="EnsemblBacteria" id="OEV35020">
        <property type="protein sequence ID" value="OEV35020"/>
        <property type="gene ID" value="HS99_0034355"/>
    </dbReference>
    <dbReference type="OMA" id="CAEIWPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198692" evidence="2">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="20193" checksum="296685F5CBFD5839" modified="2017-01-18" version="1">MPKFATPMFAAPRFTARRMLAATGVAVLALAAGACGPDTADGSGGSAATSAAVPPAAAATSSAPATGGTGGVRLVAVKSATLGPVVTDAAGRTLYRFDKDTAKPSASTCVDACAAKWPPLTAQDAVQVTGVDSALVGSVARPDGTKQVTLNGWPLYRFAGDTAAGQTNGQGVGGTWFASTPEGKKAPGTAGQAASPTVAQSGGYSGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y5</accession>
    <name>A0A1E7N2Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284769.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4737"/>
    <dbReference type="EnsemblBacteria" id="OEV35058">
        <property type="protein sequence ID" value="OEV35058"/>
        <property type="gene ID" value="HS99_0034565"/>
    </dbReference>
    <dbReference type="OMA" id="VLFHNNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198717" evidence="1">
        <location>
            <begin position="41"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="57"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="24804" checksum="72CB5B3301ADB2DC" modified="2017-01-18" version="1">MAVRPVGRRGVGRVRTTIGALAVALVAGAVVAVPTGTAEAAGAAGAGMTGSGGGSGKVVYLTFDDGPSPTYTPRILSILSRYGVHATFFEIGENVAAHPSLTAQVARQGHSVQNHSWSHPDLRRLSGPSFNSQVGNTDQAIRAQTGRTPKCLRPPYGAVNGTVRSRAAALGKQIVLWSVDPADWSRPGTGAIESRVLRNVRPGSVILMHDGGGDRSQTAAALPTILSTLKARGYSFATLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N322</accession>
    <name>A0A1E7N322_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="1">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseA</name>
        <name evidence="5" type="ORF">HS99_0034005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene422"/>
    <dbReference type="EnsemblBacteria" id="ARF78882">
        <property type="protein sequence ID" value="ARF78882"/>
        <property type="gene ID" value="B6264_08100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35080">
        <property type="protein sequence ID" value="OEV35080"/>
        <property type="gene ID" value="HS99_0034005"/>
    </dbReference>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="4">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="3">
        <location>
            <begin position="129"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="3">
        <location>
            <begin position="326"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="43389" checksum="4EE09E753C1FE68B" modified="2017-01-18" version="1">MANTSSPEAPLPVGKVSALIGGWIDRLGAVWVEGQITQLSRRPGAGVVFLTLRDPQADVSLTVTCFRSVFDQVADVVQEGSRVVVHAKPEWYAARGQLSMRASEIRPVGLGELLARLEQLKRRLAGEGLFAAERKRRLPFLPQCVGLVTGRGSAAERDVLENARRRWPAVRFEVRNVPVQGISAVERVGAAVRELDEHPEVDVIIVARGGGSVEDLLPFSDEGLVRLVAAARTPVVSAIGHEPDQPLLDFVADLRASTPTDAAKRVVPDVGEELAKVRQLRDRARRHVQSRVEREQHGLDGLRSRPALAAPHRMLDGRGQEVEGLLERARRTLRHRLDHAQSDLGHTLARVVALSPAATLERGYAVLQRADGTVVTDPAQVTAGEGLHARVAGGGFDVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N330</accession>
    <name>A0A1E7N330_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286674.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene419"/>
    <dbReference type="EnsemblBacteria" id="OEV35084">
        <property type="protein sequence ID" value="OEV35084"/>
        <property type="gene ID" value="HS99_0034025"/>
    </dbReference>
    <dbReference type="OMA" id="RTWTRYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18128" checksum="B5744001AD7D4E33" modified="2017-01-18" version="1">MRGRQTVRDMVLSMLAVGFVVWIGYLFLPHDANSDPVHVVEYKVAAASAKRAAPYPLLAPDGLSDKWRATSVSYTPADLSGGKGNAWHLGFVTPSGQYAAVEQADVPRDKLLADKVAGAQPDGTSDAAGRTWDREQGDKARALAARNGSATTLVTGTASYEELAELAQALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N398</accession>
    <name>A0A1E7N398_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285391.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000196.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4442"/>
    <dbReference type="EnsemblBacteria" id="ARF78453">
        <property type="protein sequence ID" value="ARF78453"/>
        <property type="gene ID" value="B6264_05545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35145">
        <property type="protein sequence ID" value="OEV35145"/>
        <property type="gene ID" value="HS99_0033710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="9834" checksum="4EF4296ED8E36F2C" modified="2017-01-18" version="1">MTTNDNRAGQRSLIESQVADFKNLSATATRTARQLAALKAEPHADPATIASVQETLSAEEEQLAEMAAAGKAAVEEFQGECVGQTLPPGAAEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E9</accession>
    <name>A0A1E7N3E9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CdaR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290423.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4561"/>
    <dbReference type="EnsemblBacteria" id="ARF78514">
        <property type="protein sequence ID" value="ARF78514"/>
        <property type="gene ID" value="B6264_05950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34983">
        <property type="protein sequence ID" value="OEV34983"/>
        <property type="gene ID" value="HS99_0034810"/>
    </dbReference>
    <dbReference type="OMA" id="QTLYHRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="551" mass="59944" checksum="F976852D9F15ACC9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3G4</accession>
    <name>A0A1E7N3G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289499.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6141"/>
    <dbReference type="EnsemblBacteria" id="ARF79301">
        <property type="protein sequence ID" value="ARF79301"/>
        <property type="gene ID" value="B6264_10575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35238">
        <property type="protein sequence ID" value="OEV35238"/>
        <property type="gene ID" value="HS99_0033540"/>
    </dbReference>
    <dbReference type="OMA" id="PWLRTCQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="29320" checksum="EFA667FA5C5CE546" modified="2017-01-18" version="1">MSSLSTPGTGGPEPLLLLLDPAARQTDGESVRIAKDVLCGGADVKVAYPESPSELDRMLSHRGRRRPVVIGSDLALQRVLQALHRQRELGADPVGMVPVGRAEELATARALGVPGEPVRAARAVLSGAPRTFDLLVDDGGGVALGGVRITGGARRQVGRTGGWRSLWAKLAAAEQANALTPETADHSPRVRVEADGRLLADVHRPVRLVQLTLQGAGRTDPAGAGVLEVVVSAPGALVRARAASVSVVGRGFGYEADGHAVGPVRARTWTVHPGAWGLLLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q2</accession>
    <name>A0A1E7N3Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282862.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000810.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5333"/>
    <dbReference type="EnsemblBacteria" id="ARF80740">
        <property type="protein sequence ID" value="ARF80740"/>
        <property type="gene ID" value="B6264_19140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35316">
        <property type="protein sequence ID" value="OEV35316"/>
        <property type="gene ID" value="HS99_0033200"/>
    </dbReference>
    <dbReference type="OMA" id="WASGINL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21128" checksum="FF75796A9A55262F" modified="2017-01-18" version="1">MTVLPLIFTSGLASGINAYAVVLLLGLLGRFAGAESVPHALERTDVLAAAAVLFLLEAVADKIPYVDTVWDAVHTVIRPIAGAVVGVLIAGNDPGSLSEVAAGAMGGTTALVTHLVKASLRMAVNTSPEPASNIVVSLLEDLSVAGLVTLAIFHPWVAASIAAVLLAVGLLLVRLAISRVRAFRARRRERRAAKAAAEGAFAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T1</accession>
    <name>A0A1E7N3T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2432"/>
    <dbReference type="EnsemblBacteria" id="OEV35348">
        <property type="protein sequence ID" value="OEV35348"/>
        <property type="gene ID" value="HS99_0032535"/>
    </dbReference>
    <dbReference type="OMA" id="FDSEFNC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="PTHR23300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="50895" checksum="982A90FC5A169349" modified="2017-01-18" version="1">MDSSLYRSAAEAIAAPPETLAYVAGFDRSGQRPDALLTVDTDPQSASYGKVLNFAELPTLGDELHHFGWNACSSALAHACHENPERRYLLLPGLRSSRLHVMDTHPDPVRPRLVKTVEAKELAERAGYSRPHTLHCGPDGVFLSCLGAADGGDGPGGVALLDHTTFDVLRPWETERGPQHFAYDVWWHLGTDVGVTSEWGTPWMVEDGVLPDQLLGRKYGHALHFWELGTGRHLQRVDLGDQYQMVLELRPAHDPQAEWGFAGVVVNVEDLSSSVWLWYREGPAFTARKVIEIPAVPASADELPPALQPFGAVPPLVTDINLSVDDRWLYVSAWGTGELLQYDVSDPFHPRLASSVRLGGIAARTPHPAEPGRPLNGAPQMVEISRDGRRLYLTNSLYGAWDDQFYPDGIDPWLVKLEADPVNGGLSIDERFFPHGADFRGLRVHQTHLAGGDASSDSYCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Z7</accession>
    <name>A0A1E7N3Z7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0032590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2421"/>
    <dbReference type="EnsemblBacteria" id="OEV35405">
        <property type="protein sequence ID" value="OEV35405"/>
        <property type="gene ID" value="HS99_0032590"/>
    </dbReference>
    <dbReference type="OMA" id="WFGRGSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="65"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="347"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="644" mass="68885" checksum="4284AE68436E4E65" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J2</accession>
    <name>A0A1E7N4J2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional metallophosphatase/5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0006795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551210.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000518.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene966"/>
    <dbReference type="EnsemblBacteria" id="ARF80813">
        <property type="protein sequence ID" value="ARF80813"/>
        <property type="gene ID" value="B6264_19565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35617">
        <property type="protein sequence ID" value="OEV35617"/>
        <property type="gene ID" value="HS99_0006795"/>
    </dbReference>
    <dbReference type="OMA" id="EKAQYPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015018713" evidence="7">
        <location>
            <begin position="36"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="611" mass="65930" checksum="E04AB1B83BAEC1AF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q7</accession>
    <name>A0A1E7N4Q7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551132.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000376.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80876">
        <property type="protein sequence ID" value="ARF80876"/>
        <property type="gene ID" value="B6264_19925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35678">
        <property type="protein sequence ID" value="OEV35678"/>
        <property type="gene ID" value="HS99_0007155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="31793" checksum="CD22C2E1A24A6F67" modified="2017-01-18" version="1">MAESEERRTELSGFLRSRRARLTPQEVGLAPGGRRRTPGLRREELALLAGVGVTWYTWLEQGRDIHPSPEVLASLARTLRLDRAETAYLFRLAGSHPLDGEVGAPAEVPASLLRLMHAQWPAPAWVMDANWDLRAWNPGADALFELSGRPPQECNLAWVVFGNAVHRRRVEHWEQHARRFLAQLRAAYAERGGEATAVGRHLGRMIQHVRGEHPEADRWLDEHQVAERSGAEKVLRHEELGVLRIDQHVLLAAEGLQLIVMSPRDAETAERLRRLAPMPVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V2</accession>
    <name>A0A1E7N4V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene888"/>
    <dbReference type="EnsemblBacteria" id="ARF80882">
        <property type="protein sequence ID" value="ARF80882"/>
        <property type="gene ID" value="B6264_19960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35684">
        <property type="protein sequence ID" value="OEV35684"/>
        <property type="gene ID" value="HS99_0007190"/>
    </dbReference>
    <dbReference type="OMA" id="VQEPWGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="387" mass="39515" checksum="03BC7E948F0E4380" modified="2017-01-18" version="1">MAPSPASSHAFVRPNAGRIRRSAAAALAGLTAVALLSACSYGSKAADSGSGGSADTAAATGASGAKLSSPTVKIGYFANLTHGTALVGLQEGILQKELGATQIKTQVFNAGPAEIEALNAGSIDIGWIGPSPAINGYTKSDGKSLKIIGGSASGGVKLVVNPEKISSLDDLRGKKIATPQLGNTQDVALLNYLAGKGFKVDAASGAGDVSVVRTDNKVTPDAYRQGSVDGAWVPEPTASKLVTLGAKVLLNEKDVWPDKKFVITNLIVSQKFLKEHPDVVEAVLRGSVNTNAFIKANPEKAKADANEAIKKEAGNALEPAVLDPAWADIDFLDDPLAGTLQAEADHAVTAGLLKKPNLNGIYDLTLLNKVLAAKGQAPVADAGLGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X9</accession>
    <name>A0A1E7N4X9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">HS99_0007635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene801"/>
    <dbReference type="EnsemblBacteria" id="ARF80955">
        <property type="protein sequence ID" value="ARF80955"/>
        <property type="gene ID" value="B6264_20410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35748">
        <property type="protein sequence ID" value="OEV35748"/>
        <property type="gene ID" value="HS99_0007635"/>
    </dbReference>
    <dbReference type="OMA" id="DDMFLTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21551" checksum="0C6EB6CF31E45032" modified="2017-01-18" version="1">MSESRERPTVLRITEVGEEILRRTCRTATGEDFGSERLARLIDDMFATMYVADGCGLAANQVDVDLRLFVYDCPDDDGVRHVGHVLNPVVEEQDPGRPLIEDVEGCLSVPGANTRLARPARAVVRGVDQHGEPVTIEGTGYFARCLQHETDHLNGGLYIDRLSARDRKRMMKQTADRREQVFAERAAKAAKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C8</accession>
    <name>A0A1E7N5C8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7269"/>
    <dbReference type="EnsemblBacteria" id="ARF81100">
        <property type="protein sequence ID" value="ARF81100"/>
        <property type="gene ID" value="B6264_21280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35889">
        <property type="protein sequence ID" value="OEV35889"/>
        <property type="gene ID" value="HS99_0008505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="7838" checksum="B3C7BA22840A2C8A" modified="2017-01-18" version="1">MTDSPGSAVRNPATGDLVEHAAGGVERLTGRRMPVAGGLDVTFHEAVGVGAGREPGPDALRHFTETENVFIHSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5K2</accession>
    <name>A0A1E7N5K2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551089.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene848"/>
    <dbReference type="EnsemblBacteria" id="ARF82950">
        <property type="protein sequence ID" value="ARF82950"/>
        <property type="gene ID" value="B6264_20165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35959">
        <property type="protein sequence ID" value="OEV35959"/>
        <property type="gene ID" value="HS99_0007395"/>
    </dbReference>
    <dbReference type="OMA" id="SPRELMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="25683" checksum="C0BDE78BCF15DFA7" modified="2017-01-18" version="1">MNDNHGNHRIVLITGANKGIGLATAGELARAGHTVLIGARDPERGAAAATGLAEQGLDARSVRLDVTDPATIAAAAELIAAEYGRLDTLVNNAGITRDFGTTPETLPLDDLRETYETNVFGVVAVTNAMLPPLRRSPAGLIGNVSSGLGSSAVLTDLDHPAGEHAMLLGYNTSKAALNAVTLVYARSLRDAGIKVSSLEPGHCATDLNHHSGPSSVEEGGRRIARQLGEALAGPSGQFFHPEGGNYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M9</accession>
    <name>A0A1E7N5M9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tatB</name>
        <name evidence="7" type="ORF">HS99_0031315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TatB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene481"/>
    <dbReference type="EnsemblBacteria" id="ARF78836">
        <property type="protein sequence ID" value="ARF78836"/>
        <property type="gene ID" value="B6264_07820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36002">
        <property type="protein sequence ID" value="OEV36002"/>
        <property type="gene ID" value="HS99_0031315"/>
    </dbReference>
    <dbReference type="OMA" id="PRAVITK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15602" checksum="DC6A716C11ECB34E" modified="2017-01-18" version="1">MFSDVGGLEILTLIVMAIIIFGPDKLPKLIQDTMGFIRKIRSFADTAKEDIRSELGPEFKDFEFEDLNPKTFVRKQLMGDEQDPLGLKGMKDSLDIRSVLDDKPAAPVNGRAGSVGFDKAAPAPASAGAPLQPGERPPFDPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U9</accession>
    <name>A0A1E7N5U9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene509"/>
    <dbReference type="EnsemblBacteria" id="ARF78811">
        <property type="protein sequence ID" value="ARF78811"/>
        <property type="gene ID" value="B6264_07685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36024">
        <property type="protein sequence ID" value="OEV36024"/>
        <property type="gene ID" value="HS99_0031445"/>
    </dbReference>
    <dbReference type="OMA" id="PGWNRRQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="34516" checksum="F65902B218FB5573" modified="2017-01-18" version="1">MSQLRIATFNLLHGQPLAPDGAPRPYPADAAAPLAEAIAALDADVLALQEVDRHQPRSGGTDQASVAAGAMGAGDWRFAAALHGRPAPVAGWVPDPSGPNGLRVYGPGEVGDGAPSSYGTALLTRLPVRHWRARRFAPAPFGLPLRVAGRRGLTPVPDEPRAALAAVLEGERGPFTVVAAHLSFVPGWNMAQLTGIRRWIADLPQPHLVLGDFNLVGAVPRTVLGGATALERTAPRVRVRELRAARRARPAVVVEPRRRRVREPRARLQGWYDLARTPTYPSHRPAVQFDHVLAVGVPRAAVGPAAAPRAAVSDHRPLLVRVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N678</accession>
    <name>A0A1E7N678_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835498.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8104"/>
    <dbReference type="EnsemblBacteria" id="ARF79789">
        <property type="protein sequence ID" value="ARF79789"/>
        <property type="gene ID" value="B6264_13525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36178">
        <property type="protein sequence ID" value="OEV36178"/>
        <property type="gene ID" value="HS99_0030480"/>
    </dbReference>
    <dbReference type="OMA" id="CDIEGAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028908">
        <property type="entry name" value="Tox-PL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15644">
        <property type="entry name" value="Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="920" mass="91679" checksum="B6A37C489A874999" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N680</accession>
    <name>A0A1E7N680_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284273.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8067"/>
    <dbReference type="EnsemblBacteria" id="ARF79820">
        <property type="protein sequence ID" value="ARF79820"/>
        <property type="gene ID" value="B6264_13720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36207">
        <property type="protein sequence ID" value="OEV36207"/>
        <property type="gene ID" value="HS99_0030665"/>
    </dbReference>
    <dbReference type="OMA" id="ERTQIQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18003" checksum="05EE4132D9930375" modified="2017-01-18" version="1">MTTTPPVRQIRDISGLLDHASHVLATRMAAAFTELGITPRAYCVLFHAQEAERTQIQLAELSDLDKTTMVVTVDELEKAGLAERRPSATDRRARIISVTEAGERAVVQGTAIADRVHRELLDSLPQPEREVFVSALTRLVEGHLAEPVESERSVRRARRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6D5</accession>
    <name>A0A1E7N6D5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550890.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000315.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2654"/>
    <dbReference type="EnsemblBacteria" id="OEV36267">
        <property type="protein sequence ID" value="OEV36267"/>
        <property type="gene ID" value="HS99_0030120"/>
    </dbReference>
    <dbReference type="OMA" id="CFIPDAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="34974" checksum="BE3E13C5A6AD27D2" modified="2017-01-18" version="1">MTATMLAGRLDVAKGGFAVEEVPVPAPGPGEVLIKVEAAGVCLSDVHLIDGTLKPFLLKGDKVTLGHEVAGTVHTLGAGVTGATVGDRVLLQAGEHRNGRVFTRGVDYDGGWAEYALATATTLVPIPDELPFEQACFIPDAVSTPWAAITTTGAVRPAEAVGVWGVGGLGAHGVQLLRAIGAFPIVAVDPLPAARERALAFGADTALDPADPQFTEHLRAATGGRPLAAAFDFAGVAPVREQAMATLGERGRLVLVGLTDKPLTVTDGTRVSYLRQQILGHYGSDGQDVIDLVNLVHGGRLDFARSVSGTYPLADAARAVEALERKEGNPIRLVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I5</accession>
    <name>A0A1E7N6I5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0031485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene517"/>
    <dbReference type="EnsemblBacteria" id="OEV36063">
        <property type="protein sequence ID" value="OEV36063"/>
        <property type="gene ID" value="HS99_0031485"/>
    </dbReference>
    <dbReference type="OMA" id="YRHFVVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="286"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="631"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="722" mass="78271" checksum="D5CE47DF8201D4E3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T9</accession>
    <name>A0A1E7N6T9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7169"/>
    <dbReference type="EnsemblBacteria" id="OEV36412">
        <property type="protein sequence ID" value="OEV36412"/>
        <property type="gene ID" value="HS99_0029785"/>
    </dbReference>
    <dbReference type="OMA" id="RWEFHTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16508" checksum="ADDF6A24452316A4" modified="2017-01-18" version="1">MGHEPAVAPGGFELGTDGPKVILAGLDGSDSSWRAIAYAAGLARRQGALLAVAYVQPILGAATALAGAAVEETTQEIADELLAALREAEQRVREVWRVQWRFLTMRGDPYTGLAKLADELRADAVVVGVSEQAGHKVIGSVAVRLVKAGRWPVTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N704</accession>
    <name>A0A1E7N704_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0029415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554219.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene203"/>
    <dbReference type="EnsemblBacteria" id="ARF82240">
        <property type="protein sequence ID" value="ARF82240"/>
        <property type="gene ID" value="B6264_28190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36455">
        <property type="protein sequence ID" value="OEV36455"/>
        <property type="gene ID" value="HS99_0029415"/>
    </dbReference>
    <dbReference type="OMA" id="QNIGSAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="51584" checksum="1C59074149198623" modified="2017-01-18" version="1">MTSQPSRDAEKPQPPGATAAGGRAEARRWRALTICLVAGFMTLLDVSIVNVALPTVRAGLHMSNSGLQWVLSGYALAFGLVLVPSGRLGDARSRRAVFLAGLALFTAASALAGAAQDQEWLVLARLFQGAAGGVLVPQVSGFIQTLFEGAERGRAFGALGATIGLSTAVGPLLGGLLIHLFGPQDGWRWVFLVNLPIGVVALPIAYRLLPPPRPAAERAGHRDFDPVGVLLLGAGTVALLLPFVQGQQWHGPARWLLLPLAAVLLTAFVGWELHYARRHEPLVSMALFGVRPYAAGVLLSLVYFAGFTAIFFIFTLYLQAGLHYSALTAGLAVTPFAVGSGVAAAVGGRLVSRLGRRLVVLGLLLVLLGLLASALAVQLWSGPSVGWTTLGPLLVAGVGSGLVIAPNQTLTLQHVPRARAGSAGGVLQTAQRVGSAVGIAVVGSVFFAHAAGPHPDWALAFQLADTVASGLVLAALLVALADEWANQRENAGRTQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N733</accession>
    <name>A0A1E7N733_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2648"/>
    <dbReference type="EnsemblBacteria" id="OEV36273">
        <property type="protein sequence ID" value="OEV36273"/>
        <property type="gene ID" value="HS99_0030150"/>
    </dbReference>
    <dbReference type="OMA" id="ASAYREW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27091" checksum="2ABA268D47D424A0" modified="2017-01-18" version="1">MAPVNGQILPDKWFVSRELRPEATVRLVCFPHAGGATAMFARWPAALGPGVEVAALALPGRERRIGEPAAVEVERITEAVAATADRPYALFGHSMGALLAFEVVRRLRRDGAELPVHLFVSGCPRPDHPRGGDIFDGLSRLPDAELLDRLVRGGGLPALVLDEPELLELVLPVCRADLGWLDAYDCGGEPPVPVPITAFVGTDDASARPEDAAGWAAHTTGPFTQHVVPGGHFFLDDNLDAISRAIRTGIGSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N745</accession>
    <name>A0A1E7N745_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0111 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030059626.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1486"/>
    <dbReference type="EnsemblBacteria" id="ARF79200">
        <property type="protein sequence ID" value="ARF79200"/>
        <property type="gene ID" value="B6264_09955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36498">
        <property type="protein sequence ID" value="OEV36498"/>
        <property type="gene ID" value="HS99_0028625"/>
    </dbReference>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="23106" checksum="9F77008B3C9E4A68" modified="2017-01-18" version="1">MRFSLTPKETSFYDMFAAAAENLVVGSKLLLELLGSDVSARAEIVERMRAAEHAGDDTTHAVFHQLNSSFITPFDREDIYSLASSLDDIMDFMEEAVDLVVLYDIQTLPKGIEQQIEVLARAAELTAEAMPNLRSMSNLTEYWIEVNRLENQADQIHRKLLAHLFSGQYDAIEVLKLKQVVDVLEEAADAFEHVANTVETIAVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N809</accession>
    <name>A0A1E7N809_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553009.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82436">
        <property type="protein sequence ID" value="ARF82436"/>
        <property type="gene ID" value="B6264_29360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36784">
        <property type="protein sequence ID" value="OEV36784"/>
        <property type="gene ID" value="HS99_0027650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20945" checksum="C328CD1D9EBDB688" modified="2017-01-18" version="1">MERIPDEDQLDGLRPLLESGEAVLGYEPDGPAGPGQGFADRCWVLHTLRVDGRPVRWAEALAGSGRRLADWPFTLSYLVFRDPVALVGEVELPRIGEPDRDCLVRLVEVLARHSADGQATDCRFASAAIEDLLRPVTAHRGRLDEAVAHYDAWPEGRQFPAHWWPSDGSWFVLTNWDLSAPATVRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N821</accession>
    <name>A0A1E7N821_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387149.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4845"/>
    <dbReference type="EnsemblBacteria" id="OEV36845">
        <property type="protein sequence ID" value="OEV36845"/>
        <property type="gene ID" value="HS99_0027770"/>
    </dbReference>
    <dbReference type="OMA" id="YRPEHWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="48126" checksum="B7D56727B56BEF6B" modified="2017-01-18" version="1">MADPGRAGAVEGFADRVSVLPGESFGLHVSTSAAAFTVSAYRMGWYGGARARLVWRREHVPGTRQAAPHVDQTTRTVLTGWQRTLAVDTAGWPEGAYLLRLDAEDGSGRSYVPLTVRSASTAGRTVVMSAPATWQAYNEWGGYSLYNGPTGTLATRSLRVVFDRPYGYDHGAGLFLVYEAPLVALAEKLGLPLAYTTGIDVARDPGLLHGASAVLSLGHDEYWSPEQRANVVAARDAGTNLAILGANCCFRRIRFEPTDLGPDRTVVCYKDAWAQDPGHQAGAPATTDFRVGPGADPESSMLGVIYDGYPVDAPYVVTSPDHWAFEGTGVTAGASFPHLVGVEYDRVDTAFPTPRPIEVIAHSPVVCEGRHSHSDTAYYTVPSGAGVFASGTMRWVETLDANGPGGGNADHGIDSHAGDVVRKVTENVLRAFAAGPAGRTHPARDNLTAVYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N839</accession>
    <name>A0A1E7N839_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase DegT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553053.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4859"/>
    <dbReference type="EnsemblBacteria" id="ARF82403">
        <property type="protein sequence ID" value="ARF82403"/>
        <property type="gene ID" value="B6264_29170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36814">
        <property type="protein sequence ID" value="OEV36814"/>
        <property type="gene ID" value="HS99_0027840"/>
    </dbReference>
    <dbReference type="OMA" id="IHTQIHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="39754" checksum="5335EF5EE1B07FCB" modified="2017-01-18" version="1">MGVPAARIVFDENDRAAVADAVAEMLTTGALTLGPWTERFEQAFAAEHGASHAVAVSSGTAALEMILRTVDVRGRDVVVPAVTFYATAGAVVHAGGRPVFADVDPATLALSPETLAAALTPETAAVVLVHIGGLVTPEVDALRALCDQHGVPLVEDAAHAHGSSHDGRAAGTFGLAGAFSFYPTKVTTSGEGGMVLTESPELRDEARIYRDQGKGSFSTNHHVRLGYSWRMSELHAAVGAVHLRRLKEFIEARRAVARRYDSALAGLDGMEPVLEPPGSRGNYYKYVALLAPGVDRAAFKRAVAEEYGVRLSGEVYDLPLHLQPVLAPYRRGPLPVAEDVCARQVCLPVHSDMTEDETEQVIEAVSAVHRRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8I3</accession>
    <name>A0A1E7N8I3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81720">
        <property type="protein sequence ID" value="ARF81720"/>
        <property type="gene ID" value="B6264_25000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37005">
        <property type="protein sequence ID" value="OEV37005"/>
        <property type="gene ID" value="HS99_0004010"/>
    </dbReference>
    <dbReference type="OMA" id="WGDYTSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="534" mass="58204" checksum="79C7B9D954DFDBDE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K8</accession>
    <name>A0A1E7N8K8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5985"/>
    <dbReference type="EnsemblBacteria" id="ARF81727">
        <property type="protein sequence ID" value="ARF81727"/>
        <property type="gene ID" value="B6264_25040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36998">
        <property type="protein sequence ID" value="OEV36998"/>
        <property type="gene ID" value="HS99_0003975"/>
    </dbReference>
    <dbReference type="OMA" id="IDQGIFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="47707" checksum="319A93B777C1EB73" modified="2017-01-18" version="1">MTAPVVPAQEAGLARAARELARIAERTDAVLAALPVPAQRDPRHRERAADAKNTARTARARFLDQYAEAVYRHLTADLTLHLRLPELLAAAGEEWPGLVPTAEQLASERGRLQAEKEGHEIDQGLFLRAVLRSPVAGRHLIDTMALPTERALKLLPEFLRTAELDLGSVHLARRDGAAHLTMTRPDCLNAEDNRQVDDMETAVDLVLLDPGVRAGVLRGGEMTHPRYRGRRVFSAGINLKSLHSGDISLVDFLLRREIGYINKIIRGLRVDHDGAWHTPIVEKPWVAAVDTFAIGGGAQLLMVFDRVIAAADSYITVPAAQEGIVPGAANLRLGRLAGGRVSRQVVLWGRRLRACEPDARLLVDEVVEPARMDQAIAESLARLDGPAVTTNRRMLNLAEEPPEQFRQYMAEFAMQQALRLYSADVIGKVGRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N8</accession>
    <name>A0A1E7N8N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556119.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81664">
        <property type="protein sequence ID" value="ARF81664"/>
        <property type="gene ID" value="B6264_24630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37065">
        <property type="protein sequence ID" value="OEV37065"/>
        <property type="gene ID" value="HS99_0004365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="10910" checksum="2A095ABA9AA96F54" modified="2017-01-18" version="1">MERLQHGRAVAGGDRQPVTRRPVGHQAVRDAVPDDAAMARYLAAAAVALGSPYPYGWAEDAAEAAAVRTAAHEQVDDWREQVRLPYLDMHREYGAAGKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N996</accession>
    <name>A0A1E7N996_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0005260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000097_gene45"/>
    <dbReference type="EnsemblBacteria" id="OEV37214">
        <property type="protein sequence ID" value="OEV37214"/>
        <property type="gene ID" value="HS99_0005260"/>
    </dbReference>
    <dbReference type="OMA" id="WGFAIAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="190"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="394"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="575" mass="61964" checksum="DF71330ACD2890BB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G4</accession>
    <name>A0A1E7N9G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385670.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37335">
        <property type="protein sequence ID" value="OEV37335"/>
        <property type="gene ID" value="HS99_0006000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7338" checksum="AEB85B527F6C228E" modified="2017-01-18" version="1">MTVTPVPGLGDEAIDLVNAPKGPYATQEVLAVRIGDKVLFLDGDNIVDRLPHIKDLAAPIAKHIKEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L6</accession>
    <name>A0A1E7N9L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5433"/>
    <dbReference type="EnsemblBacteria" id="OEV37358">
        <property type="protein sequence ID" value="OEV37358"/>
        <property type="gene ID" value="HS99_0006120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14222" checksum="16477A8AEE146680" modified="2017-01-18" version="1">MTGLESGSAWLLRAAGRYLVLFVLTMLVLPAVRPDTAYTYADDVVMGGVLYGLLGVLPSLGWLTVIAPVRASRWATATAATGLFAIGGFLALCLRIVHPLWPVVGILSFQLLYALILLPAPLVDAPDREDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V2</accession>
    <name>A0A1E7N9V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552653.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7933"/>
    <dbReference type="EnsemblBacteria" id="ARF79102">
        <property type="protein sequence ID" value="ARF79102"/>
        <property type="gene ID" value="B6264_09390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37471">
        <property type="protein sequence ID" value="OEV37471"/>
        <property type="gene ID" value="HS99_0025965"/>
    </dbReference>
    <dbReference type="OMA" id="HWKLVID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16352" checksum="B417431DC0336E50" modified="2017-01-18" version="1">MPLHWKLVIDCADPHRQAAFWGAALDYTVEDHSTLITRLLGADAVTPDALTEVDGHPAWRTLAAVRHPGDECDPASDTGLGRRILFQAVPEDKQRSKNRLHLDVHAGPGGRAATVARLEALGATALHDVREPGGEWTVMRDPEGNEFCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9V5</accession>
    <name>A0A1E7N9V5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="1">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="1">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552664.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7941"/>
    <dbReference type="EnsemblBacteria" id="ARF79096">
        <property type="protein sequence ID" value="ARF79096"/>
        <property type="gene ID" value="B6264_09350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37477">
        <property type="protein sequence ID" value="OEV37477"/>
        <property type="gene ID" value="HS99_0026005"/>
    </dbReference>
    <dbReference type="OMA" id="MGEHRRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="HXTX 1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="1">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21345" checksum="2B48EF66D00B5673" modified="2017-01-18" version="1">MRLFVAVLPPVAALQGLSDAVAPVRGLPGADRLRWTTVEDWHLTLAFLGEVAEDRLTELTTGLAAVAEATPAHRLRLAGAGRFGDRVLWAGVGGQTWALRRLAEAVYGATEDITAEVDAFGFHPHLTLARAGSSRGRRRAERRASAAEVEAMVAALAGYRGPDWEAAELHLMRSDQGGGGGPHYESVRAWSLARWAAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA05</accession>
    <name>A0A1E7NA05_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene8003"/>
    <dbReference type="EnsemblBacteria" id="OEV37525">
        <property type="protein sequence ID" value="OEV37525"/>
        <property type="gene ID" value="HS99_0026300"/>
    </dbReference>
    <dbReference type="OMA" id="IRARCAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="372" mass="39315" checksum="6521DCFA437B233B" modified="2017-01-18" version="1">MTMNQLLSLAVPVLLLPAWLLRRRYGSAAVTTALGAVSAAVSGAVWFAGRWTEADRWTGLVGLAELAGLLLAVALSLRSEDGPRCAAAAWTACGAVALWPSRFDGPADALTLFGFGSMLSLPTVLIGLYLRGLDEGRARAVAEARRAQRIELAHDLHDFVAHDVSGMVAQAQAGAYLASVDPARTAEMFERIEQAGQRALASLDRTVQLLRSEEAGGRSPQPGLGELVQVTEQFTAAGGAEVQLELPDQPLPREVGGTVHRIVVEALTNVRRHAGGVRRIDIRARCAGDWLELTVTNDGRSPGSVVRPRSGGGSGLPGLAARVEALGGVFEAGPHEQQTWRVTARLPLAGRAEPERPETPMRTSAGAGEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB7</accession>
    <name>A0A1E7NAB7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein HS99_0025275</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290451.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6254"/>
    <dbReference type="EnsemblBacteria" id="OEV37622">
        <property type="protein sequence ID" value="OEV37622"/>
        <property type="gene ID" value="HS99_0025275"/>
    </dbReference>
    <dbReference type="OMA" id="HAPVCAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16283" checksum="3ED2F704158CBF87" modified="2017-01-18" version="1">MALDPSFIGRSYPPTDPYEVGREKIREFAIAIGDANPAYTDAEAAKALGHQDVIAPPTFPFAIAFQAAGQVVEDPELGLDYSRVVHGDQKFRYSRPVRAGDRLTVAVTIDNIKSLAGNDVLTVRGEVADETGEHVVTAIMTLVARAADEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAH1</accession>
    <name>A0A1E7NAH1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557923.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6240"/>
    <dbReference type="EnsemblBacteria" id="OEV37634">
        <property type="protein sequence ID" value="OEV37634"/>
        <property type="gene ID" value="HS99_0025350"/>
    </dbReference>
    <dbReference type="OMA" id="HWERFTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198948" evidence="2">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="29970" checksum="A48B64F8BEBC9B40" modified="2017-01-18" version="1">MAGRQRLAALAAVAVLASGLTGCGGGDVAPATPSAGSSASSASPTTATPTGPAKPTDRSPHGVLLSAELAMQTARRAKVSYRLGADAGSGPLFWAPKTALQIKRSTPGDAEQLIVVDTVAYQGGDAATAARNGGKHWERFTVPPDPDGHKEVPYAGLIDLLNPVEALAAATADGAEASFVGEEKYEDSTVEHYRVTTTAEKYAAAQTALTQARRDNLRAALAPGGSISLTVDLWLNDKDQLVRLQRTGNGDSGRADDSVLYSDPAGPLLSAQAPAETDTVDTGVRTVSPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAI5</accession>
    <name>A0A1E7NAI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79968">
        <property type="protein sequence ID" value="ARF79968"/>
        <property type="gene ID" value="B6264_14555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37710">
        <property type="protein sequence ID" value="OEV37710"/>
        <property type="gene ID" value="HS99_0025765"/>
    </dbReference>
    <dbReference type="OMA" id="RHAEEPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6405" checksum="A2CDBC5EAC5C51CF" modified="2017-01-18" version="1">MSSTTPAPERAARTAGDGESAHRAPGEPMRALLAACAAAEAVSTPPGPRPRQAGEPEAETPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB98</accession>
    <name>A0A1E7NB98_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ORF">HS99_0024170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278338.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000638.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2047"/>
    <dbReference type="EnsemblBacteria" id="ARF79515">
        <property type="protein sequence ID" value="ARF79515"/>
        <property type="gene ID" value="B6264_11845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37961">
        <property type="protein sequence ID" value="OEV37961"/>
        <property type="gene ID" value="HS99_0024170"/>
    </dbReference>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="233" mass="24925" checksum="22C409B21E8B9D2C" modified="2017-01-18" version="1">MTTRIGVVTFPGSLDDRDAQRAVRLAGAEPVALWHRDKDLHQVDAVVLPGGFSYGDYLRCGAISRFSPVMETVIEQAKLGMPVLGICNGFQVLCESHLLPGALTRNDSLHFVCRDQKLRIENAETAWTGDYSAGQEIVVPLKNGEGRFVADAHVLDELEAEGRVVARYLAGGNAADGYGNPNGSYRDIAGITNAAGNVVGLMPHPEHAVEPLTGPTTEGLGFFTSVLKQLVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBB7</accession>
    <name>A0A1E7NBB7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79534">
        <property type="protein sequence ID" value="ARF79534"/>
        <property type="gene ID" value="B6264_11950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37979">
        <property type="protein sequence ID" value="OEV37979"/>
        <property type="gene ID" value="HS99_0024270"/>
    </dbReference>
    <dbReference type="OMA" id="HASTRYH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="31688" checksum="9D14B6C9E213ED3F" modified="2017-01-18" version="1">MKIGLLVPDSDDPTTFIAADPTQLSTSLSNSWQRQALDLLSRAVSLPSELQELAREFHAPKQPGGSIEHVQGKALIRQRVQHFRDSGMEEALALQPGGPRLPEILSGMIEQDLETLRSGTKMRTIYHASTRYHQPTRDYVATLARAGGQYRTLDEPYTRLLVMDRRVAVIPIVDDMSLAAFIYDPAVIDYLVEEVFERCWSRALEFDGARTVPQQVVSRLRQTIIDQMLEGTNHRVIARRLGISERTLARHIAEMRDDYKVDSLFQLGYVLGRKTQESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBG5</accession>
    <name>A0A1E7NBG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551653.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000757.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8149"/>
    <dbReference type="EnsemblBacteria" id="ARF79750">
        <property type="protein sequence ID" value="ARF79750"/>
        <property type="gene ID" value="B6264_13305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38040">
        <property type="protein sequence ID" value="OEV38040"/>
        <property type="gene ID" value="HS99_0022800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14513" checksum="0558F151937D0A12" modified="2017-01-18" version="1">MVLTAVPVLTIGMLGWISMLYLALVHRRRRDWLVLVAVAAASVGGVALIGPSGKDSWQATTGVVLLLGTMVFVPAYFLAVDLRPQPSGGAVPGQGTPVALLAVPPGHPPVGLPRQDRIGQVRAGLDELSAYLEQQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBL2</accession>
    <name>A0A1E7NBL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288463.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3013"/>
    <dbReference type="EnsemblBacteria" id="ARF79708">
        <property type="protein sequence ID" value="ARF79708"/>
        <property type="gene ID" value="B6264_13045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38081">
        <property type="protein sequence ID" value="OEV38081"/>
        <property type="gene ID" value="HS99_0023055"/>
    </dbReference>
    <dbReference type="OMA" id="DEHNAPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11092" checksum="AE7A42A2842B55D7" modified="2017-01-18" version="1">MPDLERLAVEHTGLAAESPHGRSAHLVLHDGMLRQTVIAMTAGTALDEHNPPTAGSVQVLRGRVSLTIAGRQLELSVGELEPVPQERHGLLAHVDSVVLLTAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB2</accession>
    <name>A0A1E7NCB2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ligand-binding protein SH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284006.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4155"/>
    <dbReference type="EnsemblBacteria" id="ARF80163">
        <property type="protein sequence ID" value="ARF80163"/>
        <property type="gene ID" value="B6264_15695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38315">
        <property type="protein sequence ID" value="OEV38315"/>
        <property type="gene ID" value="HS99_0022575"/>
    </dbReference>
    <dbReference type="OMA" id="EVFWVIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="104" mass="10645" checksum="2821ACB17F9F7AD9" modified="2017-01-18" version="1">MAWLVLIVSGLLETVWAVALESSKGFSRLVPGLVFGVALLFSMGGLAYAMRTIPIGTGYAVWVGIGAVGTALYGMAVLGDPATVARIGCLLLIVSGVVGLKVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB6</accession>
    <name>A0A1E7NCB6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pilus assembly protein TadE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289403.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5934"/>
    <dbReference type="EnsemblBacteria" id="ARF79668">
        <property type="protein sequence ID" value="ARF79668"/>
        <property type="gene ID" value="B6264_12815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38123">
        <property type="protein sequence ID" value="OEV38123"/>
        <property type="gene ID" value="HS99_0023280"/>
    </dbReference>
    <dbReference type="OMA" id="GICALSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="12838" checksum="0E9EACAA9E0C7166" modified="2017-01-18" version="1">MRSARRGDGGFVTAETAVVLPALVLLAAMLIWGVLAAAAQITCVDAARIGARAAARGETDAVELARAAAPPGARVRLAVAADTVRVDVDAPCAGPGRLGGLLAVRVGAMAVAAREDVLGGTAEGGGGSWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD1</accession>
    <name>A0A1E7NCD1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name evidence="2" type="ORF">HS99_0022615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283988.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4148"/>
    <dbReference type="EnsemblBacteria" id="ARF80159">
        <property type="protein sequence ID" value="ARF80159"/>
        <property type="gene ID" value="B6264_15660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38318">
        <property type="protein sequence ID" value="OEV38318"/>
        <property type="gene ID" value="HS99_0022615"/>
    </dbReference>
    <dbReference type="OMA" id="CRFGQRN"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="446" mass="48016" checksum="6DFE1AE7FDEAC41D" modified="2017-01-18" version="1">MTDDVLLVHGGNPLEGEIRVRGAKNLVPKAMVAALLGQGPSRLRNVPDIRDVKVVRGLLQLHGVTVRTGDEDGELILDPSHVESANVADIDAHAGSSRIPILFCGPLLHRLGHAFIPGLGGCDIGGRPVDFHFEVLRQFGATIEKHPQGTYLVAPQRLRGTKIELPYPSVGATEQVLLTAVLAEGVTELRNAAIEPEIVDLICVLQKMGAIITLGTDRTILITGVDELGGYTHRALPDRLEAASWACAALATKGDIYVRGARQLEMMTFLNTFRKVGGAFEVDDEGIRFWHPGGELKAIALETDVHPGFQTDWQQPLVVALTQATGLSIVHETVYESRLGFTGALNQMGAHIQLYRECLGGTPCRFGARNFLHSAVVSGPSKLIGAELVIPDLRGGFSYLIAALAAEGTSTVHGIDLINRGYENFMEKLRDLGAHVELPSEQLVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP2</accession>
    <name>A0A1E7NCP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene341"/>
    <dbReference type="EnsemblBacteria" id="ARF82141">
        <property type="protein sequence ID" value="ARF82141"/>
        <property type="gene ID" value="B6264_27630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38462">
        <property type="protein sequence ID" value="OEV38462"/>
        <property type="gene ID" value="HS99_0021420"/>
    </dbReference>
    <dbReference type="OMA" id="RRGAYNM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="537" mass="57460" checksum="B61DEEEFD6971A19" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCT3</accession>
    <name>A0A1E7NCT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830786.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3113"/>
    <dbReference type="EnsemblBacteria" id="OEV38516">
        <property type="protein sequence ID" value="OEV38516"/>
        <property type="gene ID" value="HS99_0021760"/>
    </dbReference>
    <dbReference type="OMA" id="NPQTRAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25944" checksum="B231F129690587B4" modified="2017-01-18" version="1">MSIGAVLAFLRDDFPEVTISKIRFLEAEGLVEPQRTPSGYRKFSPSDVERLAYVLRMQRDHYLPLRVIREHLDAIERGEAPPALPSAAETRRGPLEEADRELVASADASSGVRLGRAELLAAAEAGERELAEWESYGLVAPGPDGGYDGEALQVARLVAELGRYGLEPRHLRAMKAAADREIALVEQVVAPLRRHRNPQTRAHAEATARELAMLSVRLHAAMVQAGLRTCGQGLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW1</accession>
    <name>A0A1E7NCW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3114"/>
    <dbReference type="EnsemblBacteria" id="ARF82087">
        <property type="protein sequence ID" value="ARF82087"/>
        <property type="gene ID" value="B6264_27280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38517">
        <property type="protein sequence ID" value="OEV38517"/>
        <property type="gene ID" value="HS99_0021765"/>
    </dbReference>
    <dbReference type="OMA" id="YRLVFYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="30547" checksum="7B720B3CAEF52C1A" modified="2017-01-18" version="1">MSFFSKLFGRNKGRDAAAVEAPTARHRRAEDEPAVPGMRSAPEAGTYAGQQLYRDGAAAQYAANPAGYGASVDPSGDPRIGFPSTPSTSGGGFAPDPYAGHNPSGVPRQEAVNMAGPTPCPRCGNQNPAAARFCSNCGTALRGGLLPEGAAETTSTISISGLESYDPSATTGTGTTPALSAEVLSAIDALPPGSALLIVQRGPNSGSRFLLDSDITTAGRHPQGDIFLDDVTVSRRHVEFRRTPAGFIVADVGSLNGTYVNRERIDEVPLNNGDEVQIGKYRLVFFAGHHRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDB0</accession>
    <name>A0A1E7NDB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388002.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene703"/>
    <dbReference type="EnsemblBacteria" id="ARF82523">
        <property type="protein sequence ID" value="ARF82523"/>
        <property type="gene ID" value="B6264_00285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38696">
        <property type="protein sequence ID" value="OEV38696"/>
        <property type="gene ID" value="HS99_0019870"/>
    </dbReference>
    <dbReference type="OMA" id="VHLVGGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25764" checksum="9E5426D37ABF5FC3" modified="2017-01-18" version="1">MAGKVIAVAGASGPAGQAVLRRLTADGATVIGADIDAQRLESALDATRVAVRGAKVSGQVIDLLDPQEVHDWADHLEAEHGHVDGLFHLVGGWRGSKTFFDTRLDDWDFLHDTVVRTLQHTSLAFQPALVRSLAGRYAMVSASAAHKPTAGGAAYAAAKAATEAWTLAMADSFKKETTSPDGEPTAAAAILVIKALVSPEMRAEKPEAKFAGFTDTADLAGHLADLWDRPAAELNGQHLWLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG7</accession>
    <name>A0A1E7NDG7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0020710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388469.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000888.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1795"/>
    <dbReference type="EnsemblBacteria" id="OEV38727">
        <property type="protein sequence ID" value="OEV38727"/>
        <property type="gene ID" value="HS99_0020710"/>
    </dbReference>
    <dbReference type="OMA" id="MCSAFAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017588">
        <property type="entry name" value="UacT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03173">
        <property type="entry name" value="pbuX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="46426" checksum="4C2ED3BAFA2B3322" modified="2017-01-18" version="1">MHPVDEVLPPVKLFSTGLQHVAAMYAGVVAPPLIVGAGVGLSAADLALLISASLFTAGLATLLQTLGIWRIGARLPFVNGVSFAGVAPMIAIAEEHGPKDALPVIFGAVIVAGALCFLAAPYFCKLIRFFPPVVQGTVITLIGVSLLPVAVNWARGGSPGAAGYGSMRAIGLAAITLVAVVLCNRLLRGFWQQLSLLIGLAFGTLIAFPLGLADFGAVQDAKVFALPSPFHFGAPAFDAAAIVSMCIVMVVSMTESTADMLALGKIVEREADEPTLAAGLRADGLATALSPVFNGFAASAFAQNIGLVALTKIRSRFVVAAGGGILILLGLFPVLGSLVSLVPQPVLGGAGIVLFGTVAASGIRTLAEAGMESSANTILVSVSLGVGIIPIAVPNFYDSFPEAVRTLMHSGISAGCVMAVLLNLLFHHVGAARRSGPEPESRSGQAPGATVPTATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH2</accession>
    <name>A0A1E7NDH2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0021335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene323"/>
    <dbReference type="EnsemblBacteria" id="OEV38533">
        <property type="protein sequence ID" value="OEV38533"/>
        <property type="gene ID" value="HS99_0021335"/>
    </dbReference>
    <dbReference type="OMA" id="GAMAMER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20875" checksum="001D942A67230952" modified="2017-01-18" version="1">MDRDTYYATRPRIRAKARALFTDADGRVLLVRLRPWSDPDEQYWTLPGGGVEADRETPRTAARREIREELGWEVEPGRLLALDWQPGAAAGPGANPATGRDTAVLVYLYDGGTVSEELLDSIALQEHELVEWRLCAPTEARALLRGPSWDRVAAALAARERSAGPAELVGGQAVGDRPAGEDWGHAERDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH9</accession>
    <name>A0A1E7NDH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene643"/>
    <dbReference type="EnsemblBacteria" id="OEV38708">
        <property type="protein sequence ID" value="OEV38708"/>
        <property type="gene ID" value="HS99_0020170"/>
    </dbReference>
    <dbReference type="OMA" id="RIDWLWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24477" checksum="9448B7F57D0F8D21" modified="2017-01-18" version="1">MRKISLRITRVLSTMTAITPNGLTYLMMFTGILAGAALVVPGITGAVLGALLIQVYLLLDCVDGEVARWRRQTSLTGVYLDRVGHYMSEAALLTGLGLRATDLLHREGRGSHWEWAFLGTLAALGAILIKSETDLVDVARARSGMTAVEDSASVPRSSSVAKARRVASLLKFHRLVGAVEASLFILAAGIADAVHGGLLLTRLAVVVLAAIAMLQTVLHLLSIVLSSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU8</accession>
    <name>A0A1E7NDU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387358.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000847.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1783"/>
    <dbReference type="EnsemblBacteria" id="ARF77696">
        <property type="protein sequence ID" value="ARF77696"/>
        <property type="gene ID" value="B6264_01065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38663">
        <property type="protein sequence ID" value="OEV38663"/>
        <property type="gene ID" value="HS99_0020650"/>
    </dbReference>
    <dbReference type="OMA" id="AVYISRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27804" checksum="48DAA26575C7532C" modified="2017-01-18" version="1">MSTPAPGRHAALDQGLAGPFTSLQHALRLLEAVDRHPDGATLVALARETSLGLPTVRRLAEILEIEGYLQCQDGGWVLGGTFALLGQHNREQLVKARLNRKLAELRDELGAAVYFSRYHDGELTVEAVSAADYAPAVQEWVDFRATAHASAIGKCLLSQLDSDGRRDHLSRHPVARLTSRTVTDADQLMHRLERQPATVPVLDIQEYALGTVCAAVPITAGSTVGCLATSMPVDNIHKLKAAAELLAARAAPLMLAMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV3</accession>
    <name>A0A1E7NDV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287236.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6511"/>
    <dbReference type="EnsemblBacteria" id="ARF81284">
        <property type="protein sequence ID" value="ARF81284"/>
        <property type="gene ID" value="B6264_22395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38877">
        <property type="protein sequence ID" value="OEV38877"/>
        <property type="gene ID" value="HS99_0019660"/>
    </dbReference>
    <dbReference type="OMA" id="QSWCALS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17253" checksum="A945864F51B9C53F" modified="2017-01-18" version="1">MTATDPALTALANGWAALYVLYGRIEAHIERALQSKHELSVREYSLLDVLSRQHDGEGGHLQMKQVADAVVLSQSATTRLVSRLEDRGLLSRYLCPTDRRGIYTDVSEDGLRLLEQARPTNDAALREALDEAARNPELAPLVTAVKAVNPPALLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX2</accession>
    <name>A0A1E7NDX2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0019640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555431.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6507"/>
    <dbReference type="EnsemblBacteria" id="ARF81281">
        <property type="protein sequence ID" value="ARF81281"/>
        <property type="gene ID" value="B6264_22375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38874">
        <property type="protein sequence ID" value="OEV38874"/>
        <property type="gene ID" value="HS99_0019640"/>
    </dbReference>
    <dbReference type="OMA" id="VQWLTGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="23642" checksum="A18291867245C036" modified="2017-01-18" version="1">MSGWSGQLLLGLVVLLGATVQRLAGLGFALVAAPVLVLLLGPNSGVTLANFAALAISAVGLAGSWRQVRPGAMLPLMAAAVCTVPAGAWVAATVPTPELLVGIGVLVTAAALLVIRGVRAAALRGVGGAVVAGATSGLMNSAAGVGGPAVSLYAVNSGWTAREFVPNAQLYGVVVNAFSLAVKGVPQLNPPAWGLVTVALAGGAVAGRLLTTRVPEPRARTVVLGLALAGGVSTLVKGVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA4</accession>
    <name>A0A1E7NEA4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83194">
        <property type="protein sequence ID" value="ARF83194"/>
        <property type="gene ID" value="B6264_30080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38968">
        <property type="protein sequence ID" value="OEV38968"/>
        <property type="gene ID" value="HS99_0017820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="16213" checksum="2775EF1DAD1E2324" modified="2017-01-18" version="1">MTIERHAAEAATRFRRALETSSEETRLIGLREFPHGACLDASLLLAEYLEDCGLGTWECVAGERPFRPALPQSHAWLEQDGLILDITADQFDDAPRQAVWVTRDPSWHQQFGDPEPRARLWRPQDEELLDAYDELRAIADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL8</accession>
    <name>A0A1E7NEL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386066.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83341">
        <property type="protein sequence ID" value="ARF83341"/>
        <property type="gene ID" value="B6264_30960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39112">
        <property type="protein sequence ID" value="OEV39112"/>
        <property type="gene ID" value="HS99_0018685"/>
    </dbReference>
    <dbReference type="OMA" id="MSPADPN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042075">
        <property type="entry name" value="KorB_DNA-db"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="25304" checksum="830058CFD5B6C028" modified="2017-01-18" version="1">MSPADPNNPNEAARLTRELLDQGYTKRQVAKILGRDASLVSQFFTKGKGKAFVGALRQVVRAVRGGERDTEALSGIAEANTKRRTTKTGQKARVRGKDVVGKPGESMAGRAGKQAIKSGASHLAPVVHETGRAGGRLAFTVRMKADQYTMSAGSTEDSPGLRRGFIPRADGTEERTYGSASTGGFDAAEWSQRVADHHGDVTEAMRAWLVETGRAVEDADIAYLEVRGWVPHQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF92</accession>
    <name>A0A1E7NF92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288882.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000596.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39357">
        <property type="protein sequence ID" value="OEV39357"/>
        <property type="gene ID" value="HS99_0001190"/>
    </dbReference>
    <dbReference type="OMA" id="FHHYNIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="17723" checksum="7631111EFE343CCA" modified="2017-01-18" version="1">MATAAIARLAEDWRRAADQHLTPTKRSLMVMWAAFGTTFGTVRFITHGIRGGWLPWGNVSAGGKHLHHYNIGIAALAGVGLVAVRGDEPAVGHPAVAAVYGAGAALITDEFALLLDLQDVYWAKQGRVSVDVSFGVLAALGGYLSAAPFWHELVRRTHRRLTAGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ8</accession>
    <name>A0A1E7NFZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polynucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550292.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2725"/>
    <dbReference type="EnsemblBacteria" id="OEV39594">
        <property type="protein sequence ID" value="OEV39594"/>
        <property type="gene ID" value="HS99_0002655"/>
    </dbReference>
    <dbReference type="OMA" id="LWDRYDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MJ1316" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="953" mass="102566" checksum="55671A9F4CD12B03" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG94</accession>
    <name>A0A1E7NG94_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2906"/>
    <dbReference type="EnsemblBacteria" id="OEV39739">
        <property type="protein sequence ID" value="OEV39739"/>
        <property type="gene ID" value="HS99_0003550"/>
    </dbReference>
    <dbReference type="OMA" id="WCQDNDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YkuD" evidence="1">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="24213" checksum="F7C9D5812BEB792D" modified="2017-01-18" version="1">MALALGVAATLTGAGPGPRAWADGGPFPVPVTVGRAEQVITVEADGTRATVTLWARQDGLWRSLDSTTDARIGSGGVHDGLTRVQGSGTTPTGTYTITQGFGISPDPGTRMPYHHVTTHDWWVQDPSSAYYNRMRTDTEGGFHLTEQGALGSEHLVSHPVQYDNVLVIDFNTSPVVRGRGAGIFLHDLGPRADATGGCVAVPAAFMTRTMQWIDPADHPVVAIARRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH0</accession>
    <name>A0A1E7NGH0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2918"/>
    <dbReference type="EnsemblBacteria" id="OEV39748">
        <property type="protein sequence ID" value="OEV39748"/>
        <property type="gene ID" value="HS99_0003605"/>
    </dbReference>
    <dbReference type="OMA" id="DHTDPGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="325"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="520" mass="54270" checksum="B61E4EEA76B5743B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGT4</accession>
    <name>A0A1E7NGT4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2822"/>
    <dbReference type="EnsemblBacteria" id="OEV39673">
        <property type="protein sequence ID" value="OEV39673"/>
        <property type="gene ID" value="HS99_0003140"/>
    </dbReference>
    <dbReference type="OMA" id="IAQCTGN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27447" checksum="D092DA9BCEABAF31" modified="2017-01-18" version="1">MSLTDRAIARIRRMIREGELPPGAKLPPEQQLAADLGLSRNLMREAVKALVVARVLEIRRGDGTYVTSLAPGLLLEGLGGAVELLQGDTVLELTEVRRLFEPVATALAATRVTDEDLAEVERHLSAMRDAQDDVELLLRHDAAFHHAVARATRNETLATLLEHISGRTLSARAWRGLAEADAAGRTVAEHEAIHQALVARDPNLAQAAALMHVNTTERWLRDHLAGGEPSPPARDRPSPDPDRPGATGPVVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV76</accession>
    <name>A0A1E7MV76_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289650.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000621.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6913"/>
    <dbReference type="EnsemblBacteria" id="OEV32325">
        <property type="protein sequence ID" value="OEV32325"/>
        <property type="gene ID" value="HS99_0016615"/>
    </dbReference>
    <dbReference type="OMA" id="DHYHPWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="34721" checksum="091FD752EF242372" modified="2017-01-18" version="1">MTTAFGYFLSCEEFTPAQLVEQAELAERAGFTRLAISDHFHPWNDAQGSSPFVWGVIGALSQVTRLPVTTLVTCPTVRLHPAVTAQAAATADVQLAGGLRLGVGTGEALNEHVLGDRWPPFDVRTEMLEEAVSVMRELFTGSLVSHRGTHYTVENARLYTPPKEGRLPVYVSAFGPKAAEAAAEYADGLVTMSPDTELIGRYRAAGGNGPVIGGVKVCWSTDRERAVKTVHRLWPSELLPGELAQVLPTPRHFEQATELVTEEMVAKAVTCGDDPQEHLDRLRGYVDAGFDEVYVGQIGPDQEGFFDFYREHVLPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS9</accession>
    <name>A0A1E7MVS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0040255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000096">
        <property type="protein sequence ID" value="OEV32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738024.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7084"/>
    <dbReference type="EnsemblBacteria" id="OEV32536">
        <property type="protein sequence ID" value="OEV32536"/>
        <property type="gene ID" value="HS99_0040255"/>
    </dbReference>
    <dbReference type="OMA" id="YDRAADW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="644" mass="67183" checksum="B15772BEF51C19C2" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW76</accession>
    <name>A0A1E7MW76_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0015565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288291.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3177"/>
    <dbReference type="EnsemblBacteria" id="ARF78276">
        <property type="protein sequence ID" value="ARF78276"/>
        <property type="gene ID" value="B6264_04520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32686">
        <property type="protein sequence ID" value="OEV32686"/>
        <property type="gene ID" value="HS99_0015565"/>
    </dbReference>
    <dbReference type="OMA" id="WFACIVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8068" checksum="B1CA423939494D73" modified="2017-01-18" version="1">MVLGFSIALIVFSLLMILLVLLHKGKGGGLSDMFGGGAMSTGGGSAVAERNLDRITIVVGIGWFACILVLGLVLKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM4</accession>
    <name>A0A1E7MWM4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6089"/>
    <dbReference type="EnsemblBacteria" id="OEV32819">
        <property type="protein sequence ID" value="OEV32819"/>
        <property type="gene ID" value="HS99_0016150"/>
    </dbReference>
    <dbReference type="OMA" id="GFCYPYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="75"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="29644" checksum="745E876241375C15" modified="2017-01-18" version="1">MPRSRRPVGEPADPGSSSPWILMYHSVTVEEEDPYQLTVSPERFAEQIAWLHKRGRRGVSVRELMRARAHGRDDKLVGLTFDDGYADFARYAVPILQAYGFTATAYVVADLLGQDNGWDTEGPRKKLLTVEEVAELAVAGWEIGSHGLGHRALPGLAADVLAVQTRESRRLLEEVVGGPVTGFCYPYGAVDAPAALAVRDAGYDYACAIAHSPLTGRFALPRCYVGDRDGAWRLRAKKGRHRLRDAFTELRRRRGTRAERAVTERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX7</accession>
    <name>A0A1E7MWX7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81329">
        <property type="protein sequence ID" value="ARF81329"/>
        <property type="gene ID" value="B6264_22640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32919">
        <property type="protein sequence ID" value="OEV32919"/>
        <property type="gene ID" value="HS99_0013625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="12542" checksum="F209AD311ECBE52C" modified="2017-01-18" version="1">MDGWAPFDIEERDSDVIEDDFLSYCDDLEGPLIVVNSTSFDEDQGPFFVEASRLVDFVKAFPTRVRDYFMYASVIVVSPVTGFVIVVQDDGYIVKVRGNAIMVMQDKLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX27</accession>
    <name>A0A1E7MX27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386170.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5735"/>
    <dbReference type="EnsemblBacteria" id="ARF81388">
        <property type="protein sequence ID" value="ARF81388"/>
        <property type="gene ID" value="B6264_22955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32974">
        <property type="protein sequence ID" value="OEV32974"/>
        <property type="gene ID" value="HS99_0013925"/>
    </dbReference>
    <dbReference type="OMA" id="CVIEPGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="485" mass="51435" checksum="3351B61438B991B5" modified="2017-01-18" version="1">MTHWVPDLPVVPLHAPPHILDLIEPFRAQGTAVVDGEGSLGYAELDERSAVIATALRAAGVEPDSPVVVHARLSRWAVVGMLGVLRAGARYVPVDAGFPVARQRYIAEASGARFSVSEPGLGIRLDNLRTVQADAEGSRGETVRGTLAYTCFTSGSTGRPKGVTISASALAASTAARLEYYPTPVSTFLLCSSISFDSSVAGIYWTLACGGRLVIPSDRPADLLAVGRAAQEYRASHLLMLPSLYDIALRGGLAERAGALSTVIVAGEACPPDLVQRHFDALPRTRLYNEYGPTECTVWSAVHECTRADADLSDVPIGRAVPGTRLYVRSADGAAVPTGEPGELHIGGPGLAELGSDLYRTGDIVSVTAEAELRFHGRADHQLKLGGMRVDRSEIEQALRTHPDVEAAAVGVCSVQGRKKLVGFVSPTNGEVDQRTLRAHLIERLPAVAVPSRIVPLSRLPVLPNGKLDHGAIDQLAYDALPQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX48</accession>
    <name>A0A1E7MX48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5714"/>
    <dbReference type="EnsemblBacteria" id="OEV32989">
        <property type="protein sequence ID" value="OEV32989"/>
        <property type="gene ID" value="HS99_0014030"/>
    </dbReference>
    <dbReference type="OMA" id="AFHVVDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="26828" checksum="BCFC720AC6C5C770" modified="2017-01-18" version="1">MTGVFDALAADRGRLERASAAQRVAEVLRDHITEGRLAPGTRLSEEALGEALTVSRNTLREAFRLLADERLVVHELNRGVFVRILEPADVADIYTLRLALETAGVRALHSAAPERLAALRAALDRAEAAEAIGDWVTVGTADLHFHQAVAGIAGSRRIDECMARLMAELRLAFAAVPSARALHAPFLRRNQTLTGLLESGEIDDAEVELTSYLNDARAVIVRAMTENATTESAMGEGATAQRPMTDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY96</accession>
    <name>A0A1E7MY96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3996"/>
    <dbReference type="EnsemblBacteria" id="ARF80496">
        <property type="protein sequence ID" value="ARF80496"/>
        <property type="gene ID" value="B6264_17680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33394">
        <property type="protein sequence ID" value="OEV33394"/>
        <property type="gene ID" value="HS99_0012455"/>
    </dbReference>
    <dbReference type="OMA" id="MGVPHTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="34461" checksum="69ACDAC3B0EA5BEF" modified="2017-01-18" version="1">MRDFQALYELDERGVAAVAEANAELRDTGAGLVLLHHFEGFMDAGEAGGQVVAHLLETGSPQVVARFDHDRLVDYRARRPAMVFDHDHWTAYDPPEILLQLVRDAAGAPFLLLSGPEPDVEWERFARAVRALVERFEVRLSLDFHGIPMGVPHTRPVGLTPHGNRLDLAPGYPQWFEQAQVPGSAQALLEYRLAEAGHDVLGFAVHVPHYVARSAYPAAAVLILEAVQSASGLVLPGTRLRERVGEVYADIEEQLAQGDGELRSAIRGMEGQYDAVAGAEGRESLLAEPVDLPSAEELGRRFEEFLAEHERGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC2</accession>
    <name>A0A1E7MYC2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0039125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366416.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5908"/>
    <dbReference type="EnsemblBacteria" id="OEV33233">
        <property type="protein sequence ID" value="OEV33233"/>
        <property type="gene ID" value="HS99_0039125"/>
    </dbReference>
    <dbReference type="OMA" id="ELAHRWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21841" checksum="6BA20E90B505A211" modified="2017-01-18" version="1">MNPPPTDPAAPRPPRRRIHTRARLLASASELFLTAGFARTSIEDVCAAAGYTRGAFYSNFGSKEGLLLALFDDRAAERMAELERLAAGCEGLAPRERARLLVEALLRVEPAETGWILLFLEFRLVAARSAALAEQVAAHDRTLARAAADVLERALPELVPAGADARQAAAVILAAREGLLARTAAGGAVAEELMAATAAVLSGLLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ18</accession>
    <name>A0A1E7MZ18_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280924.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000505.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4938"/>
    <dbReference type="EnsemblBacteria" id="ARF80006">
        <property type="protein sequence ID" value="ARF80006"/>
        <property type="gene ID" value="B6264_14785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33669">
        <property type="protein sequence ID" value="OEV33669"/>
        <property type="gene ID" value="HS99_0038455"/>
    </dbReference>
    <dbReference type="OMA" id="RVCSIVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="20957" checksum="DB179020C4A6C3EC" modified="2017-01-18" version="1">MSYPPDPNNPYGQPPAPGYGYPQQAPPPAPGYGYPQQAPPPAYGYAPALPQVMPGLVMTTRVLLFVIGGVQVILAGFCLIAAAVANDAVNKTSTSSDDFISSIGHAAMGILLVIGVVWALAAALSITLGAKFGKGGNGVRITTIVYGSIAALFGVLDLIGGINTKITANIIIGLIWIAICVIWITAMCVRDGVNWFNRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ67</accession>
    <name>A0A1E7MZ67_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000222.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82793">
        <property type="protein sequence ID" value="ARF82793"/>
        <property type="gene ID" value="B6264_12515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33728">
        <property type="protein sequence ID" value="OEV33728"/>
        <property type="gene ID" value="HS99_0038250"/>
    </dbReference>
    <dbReference type="OMA" id="PLFEQNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043857">
        <property type="entry name" value="DUF5819"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19136">
        <property type="entry name" value="DUF5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="21506" checksum="DF2CD6252CC49468" modified="2017-01-18" version="1">MALCVTTALVHVLLVFLYVAPSNQISQRYSKQINAWIYPFFEQNWRLFAPNPESVSRQISARTEATSSNGSKQVSDWFDLTAVDSADVEHNIFPSHTTQNMLRRAWTSYLETHGGDDRSYSARAAMFQKYLRNIAVERVSAHQPGPFQAIQLRVTTQPIAGSPHARGPYPAAKAPVETRYLPLWKVTPNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA4</accession>
    <name>A0A1E7MZA4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0038095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288010.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7688"/>
    <dbReference type="EnsemblBacteria" id="ARF78553">
        <property type="protein sequence ID" value="ARF78553"/>
        <property type="gene ID" value="B6264_06175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33757">
        <property type="protein sequence ID" value="OEV33757"/>
        <property type="gene ID" value="HS99_0038095"/>
    </dbReference>
    <dbReference type="OMA" id="FRWWTRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10663" checksum="9A8F4BE06BE2E494" modified="2017-01-18" version="1">MHGRDAHSDEPVRVTAWVRGKVQQVGFRWWTRARALEIGLTGYASNLGDGRVQVVAEGLAADCELLLALLRGPDTPGAVSGVTEIWTAVGAGYEGFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZB3</accession>
    <name>A0A1E7MZB3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288065.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000285.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7717"/>
    <dbReference type="EnsemblBacteria" id="ARF82664">
        <property type="protein sequence ID" value="ARF82664"/>
        <property type="gene ID" value="B6264_06355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33759">
        <property type="protein sequence ID" value="OEV33759"/>
        <property type="gene ID" value="HS99_0037920"/>
    </dbReference>
    <dbReference type="OMA" id="FRNIANP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7788" checksum="1010D8619D0BA042" modified="2017-01-18" version="1">MSLAKKATKSTLSCRSTANPRRTTLASVEDFSKIPGARKPEDVVTYGTELPAVTANPRRTQLMVAPVVTVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK0</accession>
    <name>A0A1E7MZK0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium:solute symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0037250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551288.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6360"/>
    <dbReference type="EnsemblBacteria" id="ARF78765">
        <property type="protein sequence ID" value="ARF78765"/>
        <property type="gene ID" value="B6264_07395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33859">
        <property type="protein sequence ID" value="OEV33859"/>
        <property type="gene ID" value="HS99_0037250"/>
    </dbReference>
    <dbReference type="OMA" id="PYVMLQQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="536" mass="57124" checksum="5BA5427120D46FC1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N079</accession>
    <name>A0A1E7N079_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">HS99_0011730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551894.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2359"/>
    <dbReference type="EnsemblBacteria" id="ARF77959">
        <property type="protein sequence ID" value="ARF77959"/>
        <property type="gene ID" value="B6264_02585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34098">
        <property type="protein sequence ID" value="OEV34098"/>
        <property type="gene ID" value="HS99_0011730"/>
    </dbReference>
    <dbReference type="OMA" id="KHLVRAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="57" mass="6651" checksum="6FB9923905E7866F" modified="2017-01-18" version="1">MAVPKRKTSRSNTRHRRAQWKATAPDLVPIEIDGRRHLVPKHLVRAYQRGLLTPEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G7</accession>
    <name>A0A1E7N0G7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34179">
        <property type="protein sequence ID" value="OEV34179"/>
        <property type="gene ID" value="HS99_0011865"/>
    </dbReference>
    <dbReference type="OMA" id="ILKFYHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="30551" checksum="91D09576224B592F" modified="2017-01-18" version="1">MRERVQPEEIGLAVRGARRVPGLRREEVAALAGVSPTYYTRLEQSQTAHASPAILVAIARALDLSPDEEEYLLKVGTPVTERELPARRVDQISPYTRMLVDSLGNAAVAVLNYRCDILGWNSLYHRLFAPHLDFDAPKNATVRPNVIRLNFLDDNVRGLYVDWPLEARSNVSYLRFIAGNHRHDPQLAELIGELSIRSEEFSKLWISHRVANCTVGTKTFDHPSVGEFELMYQSADLGDGNILKFYHAEPDSPHDAALRLLAVDLDPVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J9</accession>
    <name>A0A1E7N0J9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1950"/>
    <dbReference type="EnsemblBacteria" id="OEV34218">
        <property type="protein sequence ID" value="OEV34218"/>
        <property type="gene ID" value="HS99_0037200"/>
    </dbReference>
    <dbReference type="OMA" id="PNAWDHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="26316" checksum="53C27FD8D0E2F994" modified="2017-01-18" version="1">MNRPAAMTPFAALHHRPGRPLLLPNAWDHASAAALAAAGHPAIGTTSLGVAAAAGLPDGAAATRAETVRLARRLGRDGFLLSVDAESGFSDDPEEVAALAVELAEAGAVGINLEDGRPDGTLAPSAVHAAKVAAVKAAVPELFVNARTDAYWCGTEGPEPEAVRRLDAYQRAGADGVFVPGLGDPAVIARLVDGLSVPLNILWSPGGPGLAELAGLGVARVSLGSLLYRSALAAAVETAAAVASGRPVGPVPGYAEVRALSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R3</accession>
    <name>A0A1E7N0R3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2601"/>
    <dbReference type="EnsemblBacteria" id="OEV34266">
        <property type="protein sequence ID" value="OEV34266"/>
        <property type="gene ID" value="HS99_0036685"/>
    </dbReference>
    <dbReference type="OMA" id="CTEFHLL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036361">
        <property type="term" value="F:racemase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="26283" checksum="E92FCAA30CC03E3C" modified="2017-01-18" version="1">MTLTATAPPAAPGDRPEHPLIGVLGGMGPLASTELLRTVYRACRLQPEQDTPRLLLWSDPAVVDRTEAIGSGELDALRRAVETSLRGLLAAGAERTVIACITAHHVLGDLPAELAERCVSLVDVVHEELAAATEPHLLLCSSGTARAGLLTSGPAGARAAERLVALHPADQDALHERIHRLKRGEDPARTIDFLRETLPRYGVRAFVAACTELHLVTRAIEDSGLGGELPSLDPLTVVARRIMNGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S2</accession>
    <name>A0A1E7N0S2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0036715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283663.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2595"/>
    <dbReference type="EnsemblBacteria" id="OEV34271">
        <property type="protein sequence ID" value="OEV34271"/>
        <property type="gene ID" value="HS99_0036715"/>
    </dbReference>
    <dbReference type="OMA" id="YSAFSRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="10">
        <location>
            <begin position="31"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="29811" checksum="53507B530C0D6857" modified="2017-01-18" version="1">MTTATPTPRTREQAGPAAGPGRPSALWPTMRAVWLRELLLFRRYWPAITFGSLIEPLVYMTGFGLGFSRLIDSVQGHPYPQFVGVGMVVTSVLFASAFAGMFESFNRRKYQKIYDAVLCQPVDVWELVTAEGSWIAVKSSVYGTAPLLVTLAIGLPPTPELLLVPLVALVSGFAFALLGMWVSCLVPAIDWLRLVVSGVLTPLVMAAGVFFPLDGLPGWVHAVAAVNPIYHCTQTVRHAAFGTLGAADALHGAVLAGFAALAWYLAVRGMRRRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N144</accession>
    <name>A0A1E7N144_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555345.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1412"/>
    <dbReference type="EnsemblBacteria" id="ARF79237">
        <property type="protein sequence ID" value="ARF79237"/>
        <property type="gene ID" value="B6264_10210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34419">
        <property type="protein sequence ID" value="OEV34419"/>
        <property type="gene ID" value="HS99_0036030"/>
    </dbReference>
    <dbReference type="OMA" id="VEEPSYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="479" mass="50937" checksum="57FB9F23CA89498C" modified="2017-01-18" version="1">MNGSWTSFGGDLHLDLTERRAAGAGLRAALEDALREAVQDGRLAPGTRLPSSRALGEDLGIARNTVVEAYGQLTAEGWLNSRQGSGTTVARRAAPSPAVRPARSPRPRPAVRHDLMPGRPDLSLFPRTAWLAAARRALATAPHEALGYGSPLGRIELREALTHYLARVRGVRTDPDHLLICSGVQQGLGLLCAALRERGTRSLAVEAYGLPPQHAVVRAAGLSTVALPLDGEGALVDRLDARCGAALLTPAHQYPTGSPLSADRRAAAVRWAREQDRYVVEDDYDGEFRYDRQPLGAMQALDPERVVYAGTAAKSLAPGLRLAWLALPDALVEPVARLKVLADTMSPVLDQLTLAELIASGTYDRHVRRCRLHYRRRRDRLVAALAEHAPHVRVTGIAAGLHAVLQLPPGSPSEAELVARAAAAGLALSSLGWHRADPTAEMAEVAEEAGPALVIGYATPPEHAFPAALEALCGMLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N150</accession>
    <name>A0A1E7N150_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290834.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7206"/>
    <dbReference type="EnsemblBacteria" id="ARF79221">
        <property type="protein sequence ID" value="ARF79221"/>
        <property type="gene ID" value="B6264_10115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34402">
        <property type="protein sequence ID" value="OEV34402"/>
        <property type="gene ID" value="HS99_0035935"/>
    </dbReference>
    <dbReference type="OMA" id="EWQGEVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="32310" checksum="9364718A7FC86CB5" modified="2017-01-18" version="1">MNDEDLRLAPRTRAADLLTWAAAAGHDRAPVAEAPLRTVLALLELGESRMHDGWPELTSDAVEHLLYERLHLYVQPAPEDDPLAYGDAVRLLVDHQRAAKRLNAKRQERLHAEAEWQGEVAAGLLRRADLVTWPRLYAVLLHAHGVDVTDPAAVREWLTGFAGLDEEQRLAGYEALVPTGWLDEPDEQGWGPGRVLSVGMATDGARRLLEQGLMRRSYRNLAELTALGRPMPEELAGDFEEFEAAAAEVALDLIGEWTVPGLPRLLVEEFPELAPEPGAEEIDAYLAQLPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F5</accession>
    <name>A0A1E7N1F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0035125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737945.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6126"/>
    <dbReference type="EnsemblBacteria" id="OEV34530">
        <property type="protein sequence ID" value="OEV34530"/>
        <property type="gene ID" value="HS99_0035125"/>
    </dbReference>
    <dbReference type="OMA" id="FQIAPEM"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="437"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1503"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2073" mass="219792" checksum="7418AB932DD2988C" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I3</accession>
    <name>A0A1E7N1I3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552829.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5588"/>
    <dbReference type="EnsemblBacteria" id="ARF79330">
        <property type="protein sequence ID" value="ARF79330"/>
        <property type="gene ID" value="B6264_10725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34544">
        <property type="protein sequence ID" value="OEV34544"/>
        <property type="gene ID" value="HS99_0035205"/>
    </dbReference>
    <dbReference type="OMA" id="FGCSTFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="351" mass="38208" checksum="37455A0B32C75944" modified="2017-01-18" version="1">MRYRVLGGTGIEVSTYCLGTMMFGAIGNPDHDDCARIINTALDRGVNFVDTADIYSAGESEEIVGKTLAARGDRDEIVLATKAHFPMGEGRARGGNSRRWIVREVEESLRRLRTDRIDLYQIHRPDHTTDIEETLAVLGDLVRAGKILAFGCSTFPAEQIVDAHHVAERRALPRFRTEQPPYSLLARGIERDVLPVVQRLGMGALTWGPLAGGFLTGRYRKGRPVDLTTGRAAINPGRFDPTLPTTAAKLDAVEAFTELAEDLGRTLPELATAFPLAHPAVTSVIIGPRTMEQLESALEAADLVLDDATLDRIDAIVPPGTDLYRADGAWQPPSLTTPALRRRPAADRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1K6</accession>
    <name>A0A1E7N1K6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552801.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5560"/>
    <dbReference type="EnsemblBacteria" id="ARF79356">
        <property type="protein sequence ID" value="ARF79356"/>
        <property type="gene ID" value="B6264_10865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34564">
        <property type="protein sequence ID" value="OEV34564"/>
        <property type="gene ID" value="HS99_0035335"/>
    </dbReference>
    <dbReference type="OMA" id="WANGFGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="75"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="30729" checksum="C261071DA600199B" modified="2017-01-18" version="1">MDPAQALIRTTLNPTARIAPGLAGRAAFELFRRPLRRSRVRPAEREVHRRAALERLTVHGKSVVGYRWGSGERPVLLLHGWRSRASRFAPFVPRLRALGLSAVAFDAPGHGDSGGRSTSVLEYRELVLRLQDRYGPFEAVIAHSLGVCAAFGALGDGLRAGRLAAVSGVSEVGFFPAAFCAGLGLDAAVERALRGRIEQDLFAGDAGAWDRYDAAGRAGAVGLPILVLHDEGDDVVPLGQAHRLKRAYGEQLDLVVTRGLGHRRIIGEPTVVDQVIGFISAGLGVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V9</accession>
    <name>A0A1E7N1V9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription-repair-coupling factor</fullName>
            <shortName evidence="1">TRCF</shortName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mfd</name>
        <name evidence="2" type="ORF">HS99_0035720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290797.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1060"/>
    <dbReference type="EnsemblBacteria" id="ARF78948">
        <property type="protein sequence ID" value="ARF78948"/>
        <property type="gene ID" value="B6264_08475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34453">
        <property type="protein sequence ID" value="OEV34453"/>
        <property type="gene ID" value="HS99_0035720"/>
    </dbReference>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132097" checksum="74021567BFA0C240" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1X9</accession>
    <name>A0A1E7N1X9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555939.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4652"/>
    <dbReference type="EnsemblBacteria" id="ARF81927">
        <property type="protein sequence ID" value="ARF81927"/>
        <property type="gene ID" value="B6264_26300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34710">
        <property type="protein sequence ID" value="OEV34710"/>
        <property type="gene ID" value="HS99_0009480"/>
    </dbReference>
    <dbReference type="OMA" id="IHGAWSR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29107" checksum="72610065BD3486CF" modified="2017-01-18" version="1">MKQTPVVLIHGAWFHRSSWEGWAERFTSHGYAVCVPGWPGEAPTAEQVRRDPGPLRDLGLAALTAHYEKIVRSFDNPPVLIGHSAGGLIAQHLLGADLGRAAVALAPLPARGVPLDHGRPRPWSLMPADSARHPCFEPLPRARFRHVVANAVGEEEAAKLFDRYAVPAPLRLLADLGLDRTAAGPADTVVNTANSARGPLLLVSGQEDRMVPDAVTRSVYKLYGDSSVVTDLKQFADRGHSLVFDSGWRSVADHVLAWLAANGIEAVAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N238</accession>
    <name>A0A1E7N238_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4585"/>
    <dbReference type="EnsemblBacteria" id="ARF81867">
        <property type="protein sequence ID" value="ARF81867"/>
        <property type="gene ID" value="B6264_25920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34770">
        <property type="protein sequence ID" value="OEV34770"/>
        <property type="gene ID" value="HS99_0009835"/>
    </dbReference>
    <dbReference type="OMA" id="TEWITYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="45936" checksum="DBE9DADF2A7F869A" modified="2017-01-18" version="1">MTDSRHVRLGLLLALPAVALTACGGTGSTAATSAGDGTGTITIWAHQGQDSENTVLQNAVNSFNGSQSAIKATLKFVPEKDYTKTLTATSASALPDIVEFDGPMMSSFVYNKKLSPISDYVLPATVANATAAVKAQGTLDGKLYGLGMYDSGLGIYANKKLLDAAGVKYPASVLDDWTAADFTAAVQKLAAANPSHKALDLKEDYGLATEWGTYGMSPIVWSAGGALVKQGKAAGALDSPAVVDAFRTFQSWKPYVDADTDGNAFVNGRVALSWVGHWAYPAYSKALGSDLTVLPLPDFGNGAKTGQGSWAWGISSGSQHAKAAGKFLDYLLDDTNVTAMTTADGAVPATKTALAASPLYRTGGPLHLFAQELAEPCGDTDITKSCVAVTRPLTAGYPVITAQFSQALNDIYGGADPQTSLAKAARAIDQDFSDNDGYSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A0</accession>
    <name>A0A1E7N2A0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556986.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3225"/>
    <dbReference type="EnsemblBacteria" id="ARF81834">
        <property type="protein sequence ID" value="ARF81834"/>
        <property type="gene ID" value="B6264_25695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34805">
        <property type="protein sequence ID" value="OEV34805"/>
        <property type="gene ID" value="HS99_0010045"/>
    </dbReference>
    <dbReference type="OMA" id="HPFVNNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="451" mass="47366" checksum="AF9173C3ED9E0592" modified="2017-01-18" version="1">MSKVVDRRRPRLLARLALLCALAAVLVLILTGPHGLLVLLAEFVGLVLMAVGAWWAITRRALPRIAGAALAVAAPIGVVVLAYGAEVLLLAVIGLALWLVGLGCARAALRAGRPARPMPVREAPPPRRPVLIMNPRSGGGKVERFDLVRRAEELGARVVLLDTSDPSLRQDVAELAREAVAEGADLLGVAGGDGTQALVAAVAAEHDLPFLVVSAGTRNHFAMDLGLDRADPATCLDALRDGVELAVDLGRVGDRTFVNTVSFGAYAQIVQSPQYRDAKAATVMDTLPDLLVGDGGTRLTAQADGHRIEAPQALLVSNNPYAAPDPVDLGRRPRLDGGVLGVLGIRVDTAAQAAELALLGERAGGLKLLSARQVTVHADAPEIPVAVDGEALTLPTPVVCTLRHRALRVRVPRDRPGADPAQQARAHRLDWRDVTRLALGRTGPSRTGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B7</accession>
    <name>A0A1E7N2B7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3202"/>
    <dbReference type="EnsemblBacteria" id="ARF81814">
        <property type="protein sequence ID" value="ARF81814"/>
        <property type="gene ID" value="B6264_25555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34826">
        <property type="protein sequence ID" value="OEV34826"/>
        <property type="gene ID" value="HS99_0010170"/>
    </dbReference>
    <dbReference type="OMA" id="YAWAWAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sensor" evidence="2">
        <location>
            <begin position="56"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="225"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="414" mass="44407" checksum="F078AE690006ECF7" modified="2017-01-18" version="1">MTIPAGLRRTVLRARRDTGFLAAGVPPHLALVPVWAWAATTTARTGNWLLTVPTSAALVLLGTPVLTAVQRARYRVLIGVDVPRLTPTAPEKRTWASTARWLAATRPWRKIGYHLVLGPLLAMLELLVLVLTAAGLAGATVYAWAWALPTGIRQDWFGNLTQRPVYTAAGLLLLCALPWTARAVVRAEAWLALGLLGPSRAQRLQERVDQLAVSRTDLIEAVDAERRRIERDLHDGTQQRLVSLAVNLGLAIATRPDLPDAREVIARAHLEAKEAIAELNDLVRGLHPAVLEDRGLDAALSGLAARTPLPVRLRVDLEERVAPSVESVAYFVISEALTNATKHASAMRAEVIVRRVGGVLRVRVTDDGLGGADAAGGTGLSWLAKRVGSLDGAFHVSSPVGGPTTITAELPCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H5</accession>
    <name>A0A1E7N2H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3221"/>
    <dbReference type="EnsemblBacteria" id="OEV34891">
        <property type="protein sequence ID" value="OEV34891"/>
        <property type="gene ID" value="HS99_0010070"/>
    </dbReference>
    <dbReference type="OMA" id="QGQPIGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="749"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="833"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="917"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="959"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1292"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1366" mass="143616" checksum="C6F59E6908C33004" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M2</accession>
    <name>A0A1E7N2M2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366422.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5882"/>
    <dbReference type="EnsemblBacteria" id="ARF82051">
        <property type="protein sequence ID" value="ARF82051"/>
        <property type="gene ID" value="B6264_27040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34926">
        <property type="protein sequence ID" value="OEV34926"/>
        <property type="gene ID" value="HS99_0035025"/>
    </dbReference>
    <dbReference type="OMA" id="PRIAWDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="34691" checksum="06DB8975AFA985C8" modified="2017-01-18" version="1">MRTGTEQQDARGEWLRFAPVQPLFRARAAQRLAVLAYHGVTDHRSFGAQLDRLRRLATPVSLEAVLQAVTERRPLPPRSVLVTFDDADRSVLTHALPALDARGIPATAFVISELIGTERPFWWHEADFLARHGGRARSLDCGHPSQLLPRLKAMPDPDRRRSLHELRVSADRRPPRQEQLTPADLLALRDGGVAIGNHTQGHPCLGRCDDATVRTEITGAHEALTHWLGEPPIAFAYPDGGHDPRAETVLQELGYRLGFLSDHRLGPRLPTHPLQISRLQVDSTTSTRRFDTILSGLEPAYRRWRRQGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M9</accession>
    <name>A0A1E7N2M9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288619.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000943.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5886"/>
    <dbReference type="EnsemblBacteria" id="ARF83092">
        <property type="protein sequence ID" value="ARF83092"/>
        <property type="gene ID" value="B6264_27060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34947">
        <property type="protein sequence ID" value="OEV34947"/>
        <property type="gene ID" value="HS99_0035045"/>
    </dbReference>
    <dbReference type="OMA" id="WDKPELD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8061" checksum="B589509776B569F0" modified="2017-01-18" version="1">MEPELAPNGKPKVDFTGAEWLCSSQGVGDVQIAFVDGYIGMRDGRQEDGPVLVFTPAEWRAFVLGARDGEFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P3</accession>
    <name>A0A1E7N2P3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0034615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287998.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7683"/>
    <dbReference type="EnsemblBacteria" id="ARF78547">
        <property type="protein sequence ID" value="ARF78547"/>
        <property type="gene ID" value="B6264_06145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34954">
        <property type="protein sequence ID" value="OEV34954"/>
        <property type="gene ID" value="HS99_0034615"/>
    </dbReference>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="46967" checksum="634EC007DE79B54F" modified="2017-01-18" version="1">MPDGFSAGDTAFVLISAALVMVMTPGLAFFYGGMVRAKSTLNMLAMSFLSLGIVSVLWVLYGYSLSFGPDAFAGLIGNLDFLGMRGIGLNELSGSIPVTAFAIFQLMFAIITPALISGAIADRAKFGAWGLFIALWVTVVYFPVAHWVFFVDNGHGGWLGDRNGVIDFAGGTAVHINAGVAGLALCLVLGKRIGFKKDPMRPHSLPLVMLGSGLLWFGWFGFNAGSALAANGVAAMAMVNTQVATGAALVGWLVFEKLKHGAFTTLGAASGAVAGLVAITPACGSVSPLGAVAIGLIAGAVCAAAVSLKYRWGFDDSLDVVGVHAVGGAIGSLLIGLFATGGVGQTAKGLFYGGGPAQLGKQAMGVAVVAAYSFVLSWLLAKAVDKLVGFRVPEEVEVAGIDQAEHAESAYDFSAVGAGLARALPSLGTGAAPGGKPAGKAAEKAAEKSAQKTAEKTEVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2W0</accession>
    <name>A0A1E7N2W0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000338.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4710"/>
    <dbReference type="EnsemblBacteria" id="OEV35031">
        <property type="protein sequence ID" value="OEV35031"/>
        <property type="gene ID" value="HS99_0034425"/>
    </dbReference>
    <dbReference type="OMA" id="FEAILCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26367" checksum="37B32C5E3A486FA6" modified="2017-01-18" version="1">MPIRGVLFDVDDTLFDYTGSEQAGILAHLRDVGLLERFPTPRAALTLWRDVMEYQYARYLARELTLRGQQIERTRQFLAHLGHGAEHLSDEQAAAWFAGYAAHRDAAWAAFPDAEPALRQLAPHYRLGIVSNSDTDHQRRKLGAIGLLDHLGDVLVCSDQHGEAKPAPGIFHAGCAALGLPPHEVAYVGDKYTVDAEGARNAGLHAFWLDRAATGAPAADGIHVLHLLTTLPHALATLTPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N332</accession>
    <name>A0A1E7N332_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286659.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35090">
        <property type="protein sequence ID" value="OEV35090"/>
        <property type="gene ID" value="HS99_0034070"/>
    </dbReference>
    <dbReference type="OMA" id="MANNQSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="8739" checksum="C5F340B89DA00504" modified="2017-01-18" version="1">MANDQSETPVPSTPGNAAQTGAPAAAVEAGKAVEGAVTASSNPAGYTAPTDADKTAFENGSFGDEGEYINEPAGEPGGPLKPESVVGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I9</accession>
    <name>A0A1E7N3I9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289496.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6144"/>
    <dbReference type="EnsemblBacteria" id="ARF79298">
        <property type="protein sequence ID" value="ARF79298"/>
        <property type="gene ID" value="B6264_10560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35235">
        <property type="protein sequence ID" value="OEV35235"/>
        <property type="gene ID" value="HS99_0033525"/>
    </dbReference>
    <dbReference type="OMA" id="FADYSEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="9321" checksum="068C1251EA97F755" modified="2017-01-18" version="1">MGRGRAKAKQTKVARELKYNSGGFDANRLSNELGVSPSTASIDPEPIEEEEDDDPYAEYAARYADLDDEDDNEPGNGPSRASRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J6</accession>
    <name>A0A1E7N3J6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0032990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282770.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5291"/>
    <dbReference type="EnsemblBacteria" id="ARF80705">
        <property type="protein sequence ID" value="ARF80705"/>
        <property type="gene ID" value="B6264_18930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35279">
        <property type="protein sequence ID" value="OEV35279"/>
        <property type="gene ID" value="HS99_0032990"/>
    </dbReference>
    <dbReference type="OMA" id="LFRTNCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="28007" checksum="0C255F5A1C51325F" modified="2017-01-18" version="1">MKKLSARRRHPLAALVVLLLALAATGGLYAAFAPADKAQADVAAQSLAIDEGKRLFAVGCSSCHGINGQGSSEGPSLVGVGSAAVDFQVGTGRMPAQQPGAQVPRKPKIYTQGEIDQLAAYISSLGPGPIAPKPEQYNSTNPDDISKGGELFRTNCAQCHNFAGQGGALTKGKYAPSLEGVDAKHIYEAMQTGPQNMPSFPDSTMPEEQKKQIVAFVRHTTNDEPNPGGLTLGSLGPVTEGLFGWIFGLGTLIAVAIWVAAHTTKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T2</accession>
    <name>A0A1E7N3T2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0033110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550008.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5315"/>
    <dbReference type="EnsemblBacteria" id="ARF82925">
        <property type="protein sequence ID" value="ARF82925"/>
        <property type="gene ID" value="B6264_19050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35332">
        <property type="protein sequence ID" value="OEV35332"/>
        <property type="gene ID" value="HS99_0033110"/>
    </dbReference>
    <dbReference type="OMA" id="AWILVED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF5931" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="308"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="41703" checksum="91657743705378D7" modified="2017-01-18" version="1">MSVELPLWKAISYFRVLALCYALLRYFNSYLHFLHPVAGWIYFGALILWTLASTRAFSNPQRCTWYVLGFDLALAVTGIVLSGLTDAPARISHGAPTLPTIWAAGTVLGFAAKGGWRPAAASGAVIGVANILGHGGPTGDNVHNIVLLLVAGCAIGYVIELARASEATLTRALQVEAATRERERLSRDIHDGVLQVLALVQRRGAELGSGAKGSGGTGSSVNGRSADGTDFAELGRLAGEQERALRALMTGGPLPAQRPPEAGAEALDPAGPRDLTALLRPYAGERITLSAPGTPVLLPGPAAGELAAAVGAAVDNVRRHAGEGARAWILVEDEPEAVTVSIRDDGPGFAPGRLGEAERAGRLGVSQSIRGRVVDLGGTAELYSAPGEGVEVELRVPRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U5</accession>
    <name>A0A1E7N3U5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285358.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000301.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4426"/>
    <dbReference type="EnsemblBacteria" id="ARF78465">
        <property type="protein sequence ID" value="ARF78465"/>
        <property type="gene ID" value="B6264_05625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35133">
        <property type="protein sequence ID" value="OEV35133"/>
        <property type="gene ID" value="HS99_0033630"/>
    </dbReference>
    <dbReference type="OMA" id="HQPTADW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="44772" checksum="1C4130B5E41D1359" modified="2017-01-18" version="1">MTEPAATPPPGCPAHAGATPLYGPRFQTDPAQLYRELRAAHGPVAPVELAGGVPAWLVIGYRELQQVTGQPQLFGRDSSRWHAWDTLPADWPLKPMMAPVPSMLYTEGEEHVRRSRAVTDALAGIDPYELRKHSEEIADRLIDGFAGRGEADLVAEYAHLMPLLVLCRVFGLDEERAPELVDAVLTMLDGGPGAPASAQRLLELMLEVVRAKAEHPGGDVASRMLAHPAGLDHDEIMRDLRVLLISGHQPSSYWISNALRLMLTDERFSASLAGGRRSISQALNEALWEDTPVQIFAGRWAVRDTQLGGQRIGEGDMLLLGFAGANADPSVRQPDGRPAEGNRAHMSYSYGEHGCPFPAQEAAEVIATTAIEVLLDRLPDLRLAVAEHALVWRPSAWVRGLVALPVSFTPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3V2</accession>
    <name>A0A1E7N3V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2422"/>
    <dbReference type="EnsemblBacteria" id="OEV35355">
        <property type="protein sequence ID" value="OEV35355"/>
        <property type="gene ID" value="HS99_0032585"/>
    </dbReference>
    <dbReference type="OMA" id="GWRVNYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="369" mass="41049" checksum="11DCF04C963D3BF5" modified="2017-01-18" version="1">MRLIHTLLGVLLLLLVVGSILRTLVVPRGLYSALVHRLWWVLRTVLRLWAAPFGTYRAQDRALTWLAPLVLLGMLGIWLSGMLLAYTLLLHGISDLSWSVSIREAGSSLFTLGYASGERLQLSAIDFLAAASGPLVIALQIAYLPTLYAAYQRRETEVTLLQSRAGEPAWGPELLARQSLVDTETALPQLYRDWERLAADIGESHSNYPVLLSFRSPQPNRSWVVGLIAVMDAAALHLALCPRSAPPEARLVIRAGFTAMRDIGRSLRVDFDTDPDPDTPIRLTYAEYLGAVAMITAAGFAHERPVEEAWRHFRGWRVNYEALAYELARRSDAVPTLWTGPRDFHAPVIPPARPTDRRPDNSRPTLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N405</accession>
    <name>A0A1E7N405_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557970.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1605"/>
    <dbReference type="EnsemblBacteria" id="OEV35429">
        <property type="protein sequence ID" value="OEV35429"/>
        <property type="gene ID" value="HS99_0032220"/>
    </dbReference>
    <dbReference type="OMA" id="VARWALI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="34713" checksum="61EBCDD3BB3824D4" modified="2017-01-18" version="1">MSSRSTTDVRPGAPSRPPAPKAGRPAGRRSLFSRLGALPWLAPAVVLILGVVVWPVVEMVSTSLRRIDTTGTDHGPAGLVKYHKLFSDPRLPGVLTWTAVWTIAVVGLTMLISLALAQLFNQNFPGRRLTRWALIAPWAASVLMTAIGFRWMLDQVAGVFNRLLLDLGLIDHSRAWLGDAAHARPWLVLVAVFVSLPFTTYTLLAGLQTVPGEVYEAARVDGATPWQTYRKVTLPLLRPAFLVGLVINLINVFNSFPVIWGMTQGGPNADTATTTVLMYMLRGYDVAESAAMSVVNFAIVILMVVVFLKVSRWNGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N414</accession>
    <name>A0A1E7N414_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290474.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1602"/>
    <dbReference type="EnsemblBacteria" id="OEV35426">
        <property type="protein sequence ID" value="OEV35426"/>
        <property type="gene ID" value="HS99_0032205"/>
    </dbReference>
    <dbReference type="OMA" id="DANCAGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="31409" checksum="97DD1177C0C86A11" modified="2017-01-18" version="1">MTRVIALDVGGTYIKGGAAGEDGVLRETDRWFTGAERGPDAVLETVLSAARELADRHRPAAAGIAVPGIVDEAAGAVVLAANLGWHRLPVRDWLAEELGLPVALGHDVRAGGLAEARIGAGRGSRDFLFVPVGTGIAAALMSDGQSVTGSHARAGELGHLVVRPGGPACPCGGRGCLETVASAAAIARRYTAATGEGGVTAKDVGERAVAGDQTAVMVWNEAIEALADALTAAITLLDPERIVIGGGLARAGDPYFAPLRAAVAERLTFQTLPQLLPAQLGHEAGCQGAALLAHDLLAHDLPHPKVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N465</accession>
    <name>A0A1E7N465_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1610"/>
    <dbReference type="EnsemblBacteria" id="OEV35475">
        <property type="protein sequence ID" value="OEV35475"/>
        <property type="gene ID" value="HS99_0032245"/>
    </dbReference>
    <dbReference type="OMA" id="WPFIAPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="35109" checksum="403979E5E0DF0BF6" modified="2017-01-18" version="1">MDDPLRTGAPRGRSAPASRAGVGPLERQRRRMFWPFTAPALTVYAVLFIAPVGYALWTSLYKWDGMGAMDWRGPQNYILLFRDPRFRTSLVNTLELMVIGGTITFVLSFALTLVLREMRARLFARSVLFFPSLVNGMVFGIAAGFLFSPTGPVNQALKLFGVTTPPKWLSTDNLLPMVLGTLVWTATGYYTSIIMAAVDQIPDYLYEAAELDGAGPFQRFRHITLPCAWDVIAVCAVLWTVSSVKIFELILLYGGSTNAYPPVSSWNTAVYVYTEAFPQGTVPRLGTATAAAMASLVMVTLITVVLRRLLRREPVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N480</accession>
    <name>A0A1E7N480_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278177.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5517"/>
    <dbReference type="EnsemblBacteria" id="ARF79390">
        <property type="protein sequence ID" value="ARF79390"/>
        <property type="gene ID" value="B6264_11075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35501">
        <property type="protein sequence ID" value="OEV35501"/>
        <property type="gene ID" value="HS99_0031885"/>
    </dbReference>
    <dbReference type="OMA" id="TPFMWIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="14773" checksum="1B6FD28FAEF6ED32" modified="2017-01-18" version="1">MAITATANLGNSRTHQVFSTAKKCITLFGVIGLITLATVAVLASTGHVSTPFMWIRGVIFPALAPVLLRLAGRATEGDYRAFDRIRTLSTVMPIAVIAVDLIPGICPAWYAVLQGLSALALLPVAVLTRTKAVTAAFPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F2</accession>
    <name>A0A1E7N4F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278732.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2439"/>
    <dbReference type="EnsemblBacteria" id="OEV35343">
        <property type="protein sequence ID" value="OEV35343"/>
        <property type="gene ID" value="HS99_0032500"/>
    </dbReference>
    <dbReference type="OMA" id="CFANGYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198748" evidence="1">
        <location>
            <begin position="31"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="21544" checksum="0BE3557CDAE14ABC" modified="2017-01-18" version="1">MRIRRTLAAASLAAIALTGAAVAPAQASAAAVLTQGGSSGPAIAVGDTLVANLASGTAATFTDGPGSTNGVSCANSSFSATVTSNPSAPGSATEQLNSQSFDSCTSSVFGVMSVQSVTATSLPYTNTVTSGSGNNVSLNGTSAGPVGITVVLNTLLGTVNCVYQSPSGITGSTSNSSNSISFADQAATLVSGPGLCFSTGYFSATYGPVTDTSAAGNPVLYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F7</accession>
    <name>A0A1E7N4F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LLM class F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550051.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000790.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5369"/>
    <dbReference type="EnsemblBacteria" id="ARF80771">
        <property type="protein sequence ID" value="ARF80771"/>
        <property type="gene ID" value="B6264_19320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35577">
        <property type="protein sequence ID" value="OEV35577"/>
        <property type="gene ID" value="HS99_0006555"/>
    </dbReference>
    <dbReference type="OMA" id="GWARQEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29658" checksum="E1D1CD7CEF70D855" modified="2017-01-18" version="1">MQLGVNVPNFGPGTDPGLLRDWARVVEGLGFDLVMVSDHVAVTADVAERYPEPFYDPFATLSWLAGVTDGRLRLGTTVLVLPYRNPLLVARMSSSLHRLSGGQFVLGVGLGWARQEFEALGVPFGARGRLTDEYLWAVRESWVKQGDGAAAPVWVGGHSEAAIRRAAELGDAWHPLRLPVERMRSVLERHELPGFAPRVALRLTDEPVPGPDRPAGVGDLEQVVADLRELHGLGAEAVVLDPYHGDPEETRRPETAWRALTAVSEAWRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z0</accession>
    <name>A0A1E7N4Z0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388315.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80915">
        <property type="protein sequence ID" value="ARF80915"/>
        <property type="gene ID" value="B6264_20170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35714">
        <property type="protein sequence ID" value="OEV35714"/>
        <property type="gene ID" value="HS99_0007400"/>
    </dbReference>
    <dbReference type="OMA" id="MSADYLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="32894" checksum="138DC9F8DB4F6723" modified="2017-01-18" version="1">MVGARRQGQTWGVEHVDRAELAAFLRRWRARIQPADVGLPAGGRRRTPGLRRQEVAQLAGMSVEYYIRLEQGRGPRPSRQMIGAISRALRLSEDETAHLHHLVGEPPLPPSAMPRDVRPGILHLLDRLDDTPAMVCSAARDVLAWNAMAAALLGDFSALPPGERNLIWRFFTDPDARALHDPAGQADFARRAVADLRSAAARYPADSDLRRLVDRLLAGSAEFRDLWARQDVEVRRSTSKRIVHPVVGPLDLDCEALHDPHRDQWTIFYTAAPGTPSHSALRLLKVVGSQDLAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B4</accession>
    <name>A0A1E7N5B4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0008455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000396.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7259"/>
    <dbReference type="EnsemblBacteria" id="ARF81093">
        <property type="protein sequence ID" value="ARF81093"/>
        <property type="gene ID" value="B6264_21230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35882">
        <property type="protein sequence ID" value="OEV35882"/>
        <property type="gene ID" value="HS99_0008455"/>
    </dbReference>
    <dbReference type="OMA" id="CPIAMDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="35346" checksum="AA230226E775734F" modified="2017-01-18" version="1">MAEPLLSVRDLVKTFAGRRGRTGRPGAPVRAVDGVSFDLGAGETLGLVGESGCGKSTTGRMIVRLLDPTSGTVTFDGTEIGGLSQARLRPHRRHLQMVFQDPYSSLNPRQTVARIISEPLLVQGAGAEEARQRAGELMELVGLIPEHLDRYPHEFSGGQAQRIGIARSLATSPKLVIADEPVSALDVSVQAQVVNLMEQLQQELGLAYVFIAHDLSVVKRVCDRVAVMYLGRIVEIGDKAQVYGNPAHPYTRALLSAVPLPDPAAERARERIVLLGDPPSPADPPAGCGFHPRCPKAQQRCRTERPLLEVVGTGGRQAACHFPEVQGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5G8</accession>
    <name>A0A1E7N5G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550053.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000790.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5370"/>
    <dbReference type="EnsemblBacteria" id="ARF82931">
        <property type="protein sequence ID" value="ARF82931"/>
        <property type="gene ID" value="B6264_19325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35935">
        <property type="protein sequence ID" value="OEV35935"/>
        <property type="gene ID" value="HS99_0006560"/>
    </dbReference>
    <dbReference type="OMA" id="SCQPCGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15255" checksum="7A00A1D7B5BC27D8" modified="2017-01-18" version="1">MITTADEALLRRAIGIAARAVELGDAPYGSLLAGPDGTVLAEAHNTVRRDDDITAHPELKLARWAARVLDEEAAARATLYTSCQPCGMCAGALVRSGIGRVVYALATAQLVELNPASGAWPVVAHDGPALFDEARGPIEAYYREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I9</accession>
    <name>A0A1E7N5I9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene845"/>
    <dbReference type="EnsemblBacteria" id="ARF82951">
        <property type="protein sequence ID" value="ARF82951"/>
        <property type="gene ID" value="B6264_20180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35960">
        <property type="protein sequence ID" value="OEV35960"/>
        <property type="gene ID" value="HS99_0007410"/>
    </dbReference>
    <dbReference type="OMA" id="RSNWARK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="21222" checksum="1CCBE15E258F3210" modified="2017-01-18" version="1">MTPQHQIRADYDARTIVVYQAYSSTIADAALRAGRFVTPFSFQRMTWIKPSFLWLMHRSNWARKPGQERVLAVRMTREGWEQALSQAVHTTADPKAVAQAAVHLQWDPERSLRGAALNHYSIQVGIGRHLIRTFAEEWVVGLTDLTPQVHKAAALVRNGRAAQAQRLLPAERVYPMSRTMEAHLSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L6</accession>
    <name>A0A1E7N5L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0006535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387742.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000366.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5365"/>
    <dbReference type="EnsemblBacteria" id="OEV35934">
        <property type="protein sequence ID" value="OEV35934"/>
        <property type="gene ID" value="HS99_0006535"/>
    </dbReference>
    <dbReference type="OMA" id="VFAFYIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="38978" checksum="E1C793344C1DEBFA" modified="2017-01-18" version="1">MWWIWLAAYPVTAVFVLSNAATPLYVLWQHDIGFSKGTLTVVFAFYIVGLIGSLLVSGVASDRVGRKPVLLPALALGLTACLIFGTATSVAALIVARLFTGIAVGAVVSAGMAAVTDVAGPERKRTAALLASCAMVFGAGLGPLLAGVLSELAPAPTTTVFVVEAAVLAGAVLVVLRMPVRRPEGGGRGAWIRVPGVPRGNGRQLALGIAVFAPGITATSFVLSLGPSLLSGLLGTTNRIVAGAMAFAMFLAATGVQFAVQRLRRRTVLTAGAAATALSMVTLAVAVHTEAVAVLVLAALLAGAGQGMDQLGGLSLLNAGIPPQRLAEANAAFNVGGYVPAGLLPVSAGYLSDAVGLTSGATVFAAVLLGLAALGGLVVLATGRTVTDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V3</accession>
    <name>A0A1E7N5V3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6347"/>
    <dbReference type="EnsemblBacteria" id="OEV36072">
        <property type="protein sequence ID" value="OEV36072"/>
        <property type="gene ID" value="HS99_0031665"/>
    </dbReference>
    <dbReference type="OMA" id="ETRCART"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10460" checksum="AA75839D4D23D2D4" modified="2017-01-18" version="1">MLLSELVTNAVTHARTPRGRLLFVRLQLLPHGTLRIEVHDADSAKPAPHPTSLTSESGRGLLLVRELASEWGCCPRRGGIGKFIWCHVSASPEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y9</accession>
    <name>A0A1E7N5Y9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 9">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0031060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 9"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281003.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4988"/>
    <dbReference type="EnsemblBacteria" id="ARF80055">
        <property type="protein sequence ID" value="ARF80055"/>
        <property type="gene ID" value="B6264_15040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36110">
        <property type="protein sequence ID" value="OEV36110"/>
        <property type="gene ID" value="HS99_0031060"/>
    </dbReference>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Phosphate binding" evidence="10">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="28522" checksum="DDE1D3DA6C267CB0" modified="2017-01-18" version="1">MNASPQSVVSADPYAAAQAAAERLRELTGAERHDVALVMGSGWVPAADALGETVAEFPVTDLPGFPAPAVAGHAGKIRSVKIGDKRALIFLGRNHYYEGHGVATVVHGVRTAAAAGCGVIVLTNGCGGLRQGWTPGQPVLISDHINLTADSPIVGANFVDLTDLYSKRLRALCREVDPSLDEAVYVQFRGPHYETPAEVNMARVIGGELVGMSTTLEAIAAREAGSEVLGISLVTNLAAGMTGEPLNHEEVLEAGKASAERMGELLAKVLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N640</accession>
    <name>A0A1E7N640_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366717.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8125"/>
    <dbReference type="EnsemblBacteria" id="OEV36162">
        <property type="protein sequence ID" value="OEV36162"/>
        <property type="gene ID" value="HS99_0030380"/>
    </dbReference>
    <dbReference type="OMA" id="IAPWERA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="197"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="30908" checksum="098C8BAA4D2E7D0E" modified="2017-01-18" version="1">MSTVPPMGPALRRLAVRATAQAAAWQPRIGHAVRSRAVAPLRLLATPRHATLPGSRQRVERDHAVVSVGAAALMAGVVLAAAPGSASAQTVRPTTPGSSAFTAPRAKVPDPGLVQVAGPSPYKLPDGAPSAQAFVAVAPNLLPPGAEPAEPAPAAAPAPEPEPAPAAPPEPGWSAPVPDAPTSNPFGVHDSEYAAGYHTGVDFAVSPGTPVLAVGDATVVSAAWDGAYGKEVVLRLADGHFAQYAHLSTLSVSAGRRVSAGERVGLSGNTGNSTGPHLHFEIRTSNRYGAVVDPIAYLSGHGVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N696</accession>
    <name>A0A1E7N696_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284294.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79811">
        <property type="protein sequence ID" value="ARF79811"/>
        <property type="gene ID" value="B6264_13665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36198">
        <property type="protein sequence ID" value="OEV36198"/>
        <property type="gene ID" value="HS99_0030610"/>
    </dbReference>
    <dbReference type="OMA" id="FAETSHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="7998" checksum="3136D03F1870EC15" modified="2017-01-18" version="1">MKSKLAKTALTAAAALALAGAATPAFAHVGLEGGGGIVASADQPFLAGGGGGVAHTSDIVAGGGGGGAATATDLVGGGEGFAHIKGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N3</accession>
    <name>A0A1E7N6N3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280510.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7184"/>
    <dbReference type="EnsemblBacteria" id="ARF82341">
        <property type="protein sequence ID" value="ARF82341"/>
        <property type="gene ID" value="B6264_28795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36366">
        <property type="protein sequence ID" value="OEV36366"/>
        <property type="gene ID" value="HS99_0029860"/>
    </dbReference>
    <dbReference type="OMA" id="IWTINAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="21935" checksum="81BBF971C90CEC76" modified="2017-01-18" version="1">MAENPSTQPARRRAPAMDPEQRRAMIVAAALPLVVEYGAAVTTAKIARAAGIGEGTIFRVFADKDALLAACLAEALRPDDAVAHLAAIELDQPLADRLTEAADVLSGHLARVGAVIGALAGAGRPERAERPAPAEARRSADREAGLAAPRAALAALFEPDRDRLRLAPERLAGTFQLLLMSTGRAGMPDPLSTGELVDLFLHGAIATTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N786</accession>
    <name>A0A1E7N786_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000557.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1435"/>
    <dbReference type="EnsemblBacteria" id="ARF79158">
        <property type="protein sequence ID" value="ARF79158"/>
        <property type="gene ID" value="B6264_09705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36539">
        <property type="protein sequence ID" value="OEV36539"/>
        <property type="gene ID" value="HS99_0028880"/>
    </dbReference>
    <dbReference type="OMA" id="SEHRSQW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="16059" checksum="53312451BDEF56B5" modified="2017-01-18" version="1">MSEPIRVRGSVVVPDAELVWRFSRSSGPGGQHVNTSDSKVELRYDVAASKALPEVWRTRALERLANRLVDGRVLVVQASEFRSQWRNREAAAARLAAVLSEACAPPPKARRATRPSRGTVERRLNNKRHRSELKQGRRSPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E7</accession>
    <name>A0A1E7N7E7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PRC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000524.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7780"/>
    <dbReference type="EnsemblBacteria" id="ARF82288">
        <property type="protein sequence ID" value="ARF82288"/>
        <property type="gene ID" value="B6264_28490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36627">
        <property type="protein sequence ID" value="OEV36627"/>
        <property type="gene ID" value="HS99_0028020"/>
    </dbReference>
    <dbReference type="OMA" id="DYYHRLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13882" checksum="5331D730E3EA5610" modified="2017-01-18" version="1">MNERHNIWEFRTAAGHTAGTDLVGFHVEATDGAIGKVDKLSEEVGEQYLVVDTGPWIFGRRVLLPAGTVTRIELGERKVYVDRSKDEIKHSPELDDAEPHQENDTRERFGPYYDRLYGGRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U9</accession>
    <name>A0A1E7N7U9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0027600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284633.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4811"/>
    <dbReference type="EnsemblBacteria" id="OEV36776">
        <property type="protein sequence ID" value="OEV36776"/>
        <property type="gene ID" value="HS99_0027600"/>
    </dbReference>
    <dbReference type="OMA" id="KYNGYEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="156"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36845" checksum="DB5166B4A176EACD" modified="2017-01-18" version="1">MTADLTGRHYLRELDFTAAEIHHLLDLAAELKAARRAGTEIPRLTGRRIALIFEKSSTRTRCAFEVAAADQGAMTTYLGPDGSHIGHKESIADTARVLGRMYDAIEYRGFDQDAVTELAARAGVPVYNGLTDQCHPTQSLCDVFTMREHSAKPLGEISFCYLGDARNNTANSLMVMGSLLGMDVRIAAPRDLWPDSELVSECLRLGRDSGARFTLTDEVEEAVRGADYLYTDVWVSMGEDHARWPERIARLLPYQVNAKTLAATGNPDTAFLHCLPALHDRRTDLGAELAAEHGLDGLEVTDEVFESPASLVFDQAENRMHTIKAILVATLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Z4</accession>
    <name>A0A1E7N7Z4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386103.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36764">
        <property type="protein sequence ID" value="OEV36764"/>
        <property type="gene ID" value="HS99_0027530"/>
    </dbReference>
    <dbReference type="OMA" id="EQTRHEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="17162" checksum="9A95727DD299FEBE" modified="2017-01-18" version="1">MTQPPHDEPIASSVEELREQAERTRAELGETVQALAAKTDVKARAQEKAAEVKEQAAAKAGELREQAALKAGELKATVADLAHQAQDRLPDPVRDKAAQAAGQARAKAAEVGHLWEEKAPEPVREKTARGAQLARDNRTVLVAAAGVAVLVWLACRRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N877</accession>
    <name>A0A1E7N877_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0026930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281959.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000372.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6488"/>
    <dbReference type="EnsemblBacteria" id="ARF78651">
        <property type="protein sequence ID" value="ARF78651"/>
        <property type="gene ID" value="B6264_06755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36900">
        <property type="protein sequence ID" value="OEV36900"/>
        <property type="gene ID" value="HS99_0026930"/>
    </dbReference>
    <dbReference type="OMA" id="TAFCDGY"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="53194" checksum="F47BB9B54DDD1177" modified="2017-01-18" version="1">MSEPSRSQAHVQPDAPAGTAAPAGLRGTGPRRTALGVSELVQAALPLIAEWLPTQRWYAGKGRPITGLVPVVGTPLQVGDPALLHLLLRVEHATTAGLPHGDTYQLLLGIRSQGPSGIEPGAVLGRLSQGPYDGATLYDAVHDPELTGRLLEHLATGDRFGSLSFRRTPGSGLPTNLPGRASTAEQSNSSVIYGTSYILKLFRRIHPGTNPDLELSLALSRAGSTRIPRVAAWFESRMERAEPATLGLLQRYLPDAEDGWELALDQVGRLKGDRSPGNFAIEAHRLGRATAEVHRVLSRSMPVARLDRTQTGRLATAMADRLDSAVAAVPGLLRFRAALRTAFQQLADAHPDGLPVQRIHGDLHLGQAMRTPHGWVLLDFEGEPAKSVTERREPQPALRDVAAMLRSFDYAAAHLLAGGPVDPELAHLAAAWAQRNRTAFCAGYTAGGGADPAASPELMRALEIDKAVYEVVYEARHRPSWLPIPLAAINRLALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8B2</accession>
    <name>A0A1E7N8B2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553729.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6825"/>
    <dbReference type="EnsemblBacteria" id="ARF78619">
        <property type="protein sequence ID" value="ARF78619"/>
        <property type="gene ID" value="B6264_06565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36935">
        <property type="protein sequence ID" value="OEV36935"/>
        <property type="gene ID" value="HS99_0027125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="393" mass="40837" checksum="F776B503AF618BFD" modified="2017-01-18" version="1">MNRSRRIAAVAALVLALPLPMAGAAMASPSPSATTAAAAAVAPAAFHAELPRPTGRYAVGEEVLHLTDHSRTDPWVPSAGPRQLAVSMFYPARPGTGEPAPYMTLGEAQGFVATRVPAGTGLQPQDVVNIDTHAYTGAKAAGGKFPLVVLSPGFENPRATLTGLATDLAGHGYVVALVGHTHEDSGETLADGSTPGCALCDTGAPDSLPDSRAKDVSFVLDQLTGHHPAWRLAHLIDRDRVGMAGHSIGGASALTAMAEDRRILAGVNMDGAFWPPIPTDKLEGRAFLLLGKQSDHAVGGGETSWGRTWAGWEGYKPWLAVAGTNHSSFTDVPVLAAAAGLPFPPGTTTSPERGMQLTREYVGAFFDQSLKGIHQPLLDGPSAANPEVLFQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D3</accession>
    <name>A0A1E7N8D3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6847"/>
    <dbReference type="EnsemblBacteria" id="OEV36914">
        <property type="protein sequence ID" value="OEV36914"/>
        <property type="gene ID" value="HS99_0027015"/>
    </dbReference>
    <dbReference type="OMA" id="TYALYSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="169"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="30675" checksum="77896E2AD9EB8F89" modified="2017-01-18" version="1">MSAPERARLTPAPRRTRPIDGPLPILVSALLWGTTGTAASFAPAGAPAAGIGAAALVLGGSLLFLTDRAAWALPRVCGMVERWLLVVGAVAVVGYPVTFYPAVTRTGVAVATVIALGSAPVFTGLLGWLARQGRPSGRWAGATALAVLGCGVLVLGPQLTGGGSTVDLLGALLAALSGLSYAVYSLIAGRLIAAGHPSGGVMGAMFGGAAVLVLSVLLAGPTGWLLSVRGAGVVLHLGVVTTFLAYRLFGHGLRHTPAQIATTLTLAEPAVAAVLGVAALGERLPTVSWCGLAVLAGGLGVLTLPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D4</accession>
    <name>A0A1E7N8D4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000510.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4749"/>
    <dbReference type="EnsemblBacteria" id="OEV36733">
        <property type="protein sequence ID" value="OEV36733"/>
        <property type="gene ID" value="HS99_0027300"/>
    </dbReference>
    <dbReference type="OMA" id="YEVAHEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="39393" checksum="AB4611F0598D0271" modified="2017-01-18" version="1">MAQKSVRWPPYVRVAPWLLIVGGLVWNSLDPSDYWGDPLLAAAAVLSGALLTLRDTLAVGVANVTGILVLSLRDGSLGTQDGYLELVNTALAAVLGVGVNLVVARHGRRLARVRSVAEAAQRAVLPEPPRWVAGLEVAACYRAAQDEALIGGDAYALQDTPYGVRVLIADVRGKGLHAVGAVSVLLGVFREDAHREPDLAALADALERTLARESAALGEELRLEGFITALLVEFPPGEAVARTLDCGHPGPYLLGDGGPTVSRWDAADPGLPLGMGVLGVARPEVETRAFPPGCTLLLVTDGVTEARDAAGEFYDPVQGLAPLGPFAGPREAVDALVADVARWTGGPRDDDMAVLAVSRRGDAAGVGEPVRAGAESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E6</accession>
    <name>A0A1E7N8E6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="4" type="ORF">HS99_0026940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551384.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000372.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6490"/>
    <dbReference type="EnsemblBacteria" id="ARF82671">
        <property type="protein sequence ID" value="ARF82671"/>
        <property type="gene ID" value="B6264_06745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36962">
        <property type="protein sequence ID" value="OEV36962"/>
        <property type="gene ID" value="HS99_0026940"/>
    </dbReference>
    <dbReference type="OMA" id="RPNFWPN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="525"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="651" mass="72455" checksum="8103CB1097097723" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N5</accession>
    <name>A0A1E7N8N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37057">
        <property type="protein sequence ID" value="OEV37057"/>
        <property type="gene ID" value="HS99_0004310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="38" mass="4232" checksum="59DC57DAC7C4B3A8" modified="2017-01-18" version="1">MVGFGKEFDVNTGPWEFLLLEKSTVDEVLAQYSSPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N956</accession>
    <name>A0A1E7N956_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37222">
        <property type="protein sequence ID" value="OEV37222"/>
        <property type="gene ID" value="HS99_0005310"/>
    </dbReference>
    <dbReference type="OMA" id="GVLKRWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6766" checksum="91293AC5B903142C" modified="2017-01-18" version="1">MEFYREMGEADVETIGGVLKRWWLRAELYRDPEGDRIHAAVQAGTAPGTSASAVLRRFGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N985</accession>
    <name>A0A1E7N985_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0005530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555183.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1308"/>
    <dbReference type="EnsemblBacteria" id="OEV37260">
        <property type="protein sequence ID" value="OEV37260"/>
        <property type="gene ID" value="HS99_0005530"/>
    </dbReference>
    <dbReference type="OMA" id="WESINAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="435" mass="44014" checksum="D1AC71737104ED53" modified="2017-01-18" version="1">MYLADSRHTPVSDTAPAPRPGRPARIATTVLALGTVSLVTDVSSEMVTAVLPLYLVTVMAVSPLGFGVLDGVYNGATVVIRLLGGLLADRPGGHDAHGHGTDGHGRHKAVAAAGYGLSALCKPALLLARTTPVLGLVLAVDRAGKGLRTAPRDALISLSAPPERRARAFGVHRAMDTVGALAGPLLAFLILRAAPGGYHAVFTVSACVAALGVLVLVLCVPARPGGMVGGVLPLPAGRPVARLLRLPGLRRVCLCAALLGLATLSDSFVYLFAQRRLGLPAGWFPLLPLGTAAVYLLLAVPLGAAGDRYGRRRVFVLGHLALLSGYALLLLRPAGGLPVAAVVLTLHGLFYAATDGMLAAATAAVVPASRQGAGLALVSTGQAAGRFGCSLTVGVLWARWGDGAALAAMTAALAGAVAVAAYVLRPGPARGKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L1</accession>
    <name>A0A1E7N9L1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556398.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82490">
        <property type="protein sequence ID" value="ARF82490"/>
        <property type="gene ID" value="B6264_29715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37376">
        <property type="protein sequence ID" value="OEV37376"/>
        <property type="gene ID" value="HS99_0006240"/>
    </dbReference>
    <dbReference type="OMA" id="FAMHGEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8261" checksum="8B76F246832B021B" modified="2017-01-18" version="1">MRLVVDLNRCQGYAQCVFLAPDVFALHGDEALLFSPRFDEAQRDRVEEAAAACPVQAILVDYSDEPTRGAEPHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY0</accession>
    <name>A0A1E7NAY0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">HS99_0024995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6019"/>
    <dbReference type="EnsemblBacteria" id="ARF78023">
        <property type="protein sequence ID" value="ARF78023"/>
        <property type="gene ID" value="B6264_02985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37839">
        <property type="protein sequence ID" value="OEV37839"/>
        <property type="gene ID" value="HS99_0024995"/>
    </dbReference>
    <dbReference type="OMA" id="HTRRRWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8937" checksum="CE20DEFC789CFF71" modified="2017-01-18" version="1">MSAHCQLTGRIPGFGNAISHSHRRTRRRFDPNIQTKRYWLPSENRFVRLTLSAKGIKTVDKLGIEKAVARLHARGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ5</accession>
    <name>A0A1E7NAZ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="8" type="ORF">HS99_0025075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556720.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6000"/>
    <dbReference type="EnsemblBacteria" id="ARF82583">
        <property type="protein sequence ID" value="ARF82583"/>
        <property type="gene ID" value="B6264_02890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37876">
        <property type="protein sequence ID" value="OEV37876"/>
        <property type="gene ID" value="HS99_0025075"/>
    </dbReference>
    <dbReference type="OMA" id="DKMVLQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="618" mass="66301" checksum="589875B7CAC25D77" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB67</accession>
    <name>A0A1E7NB67_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278310.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000452.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2062"/>
    <dbReference type="EnsemblBacteria" id="ARF79501">
        <property type="protein sequence ID" value="ARF79501"/>
        <property type="gene ID" value="B6264_11760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37946">
        <property type="protein sequence ID" value="OEV37946"/>
        <property type="gene ID" value="HS99_0024085"/>
    </dbReference>
    <dbReference type="OMA" id="VDVRRHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="30269" checksum="8E623C1E4706D5B5" modified="2017-01-18" version="1">MTDNQTVQAYTEAWTHSIESISELVAPLPEGSWNRATECPGWSVRDVVSHVIAVESELLGDPRPIHSLPRDLRHVTTEFARYIELPVDKRRCHTALEMTSELEYTIIRRSRALRNAKQTPGELVRWPAGPLAGELPYHELLRMRAFDVWVHEQDLRRALDTPGNLAAPGALVARDFLLERLPKAVAHTAGAPAGTTLVVDVTGPVEFLRTVRVDSTGRGSVDESISLAPDVQLTMDWETYVRLACGRGRPGPVTVEGDKELAERVLANFSVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBH2</accession>
    <name>A0A1E7NBH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737814.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8144"/>
    <dbReference type="EnsemblBacteria" id="OEV38035">
        <property type="protein sequence ID" value="OEV38035"/>
        <property type="gene ID" value="HS99_0022775"/>
    </dbReference>
    <dbReference type="OMA" id="ITCGGPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198957" evidence="3">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18244" checksum="5DDADABE66C25419" modified="2017-01-18" version="1">MSKSRTHRSPARTTPVGAPTASARTLAASPPTRLLIPAISVDAPVTDLGLNADGTVQVPSADHADQVGWYRNGPTPGEAGPAVLIGHLDTRNGPAVFRRLPELHPGDLIRIRRSDGGSVDFKVRSLLQAAKDHFPTDAVYGDTPGPALRLITCGGRIGSDGHWTDNIIVLADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX1</accession>
    <name>A0A1E7NBX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288098.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7153"/>
    <dbReference type="EnsemblBacteria" id="OEV38190">
        <property type="protein sequence ID" value="OEV38190"/>
        <property type="gene ID" value="HS99_0023345"/>
    </dbReference>
    <dbReference type="OMA" id="YRWMVRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="32849" checksum="7FFDC29829B272D8" modified="2017-01-18" version="1">MRQSGPWGHRDLAANGARFHITELGSGPLVLLVHGWPEYWWAWRHQLTALAAAGYRAVALDLRGIGGSDRTPRGYDPGNLALDITGVIRSLGERRAHLVGHASGGTLAWVAAVMRPSVIQSLTVVSAAHPRDLRRALLTDRKQMAAFDHVLGFQRPWIPERRLVADDAALVGRYLDEWTGPNKLDEAAVHAYRQAIQIPSTAHCSIEPYRWLLRSMARPDGIQFARRMKKPITAPTLHVQGASDPVLLPHTALGGGEYVAAPYRWRLMPGVGHFPHEEAPEEFTAELLDWVGRHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX3</accession>
    <name>A0A1E7NBX3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1903"/>
    <dbReference type="EnsemblBacteria" id="OEV38192">
        <property type="protein sequence ID" value="OEV38192"/>
        <property type="gene ID" value="HS99_0023480"/>
    </dbReference>
    <dbReference type="OMA" id="RFTWELG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="13390" checksum="F34F42E2F87AB97F" modified="2017-01-18" version="1">MTEITAATLQQLAERYLAVWNETDPAARRKLIDEVWAEDGRYTDPLAAVVGRDAIDALIGAAQAQFPGLEFTLGPVDAHHDIARFTWNLGPAGAEPVVIGFDVLAATPEGRIATVHGFLDRVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC30</accession>
    <name>A0A1E7NC30_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8140"/>
    <dbReference type="EnsemblBacteria" id="ARF79758">
        <property type="protein sequence ID" value="ARF79758"/>
        <property type="gene ID" value="B6264_13350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38033">
        <property type="protein sequence ID" value="OEV38033"/>
        <property type="gene ID" value="HS99_0022760"/>
    </dbReference>
    <dbReference type="OMA" id="DRRWEEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="10337" checksum="867BE3C413396437" modified="2017-01-18" version="1">MGAAVGGGVPSAALAAGLGSAVCGTLYSTTVQHWVPPELLGRLSAFGAVGSFAVGPLGLAAAGPLSARYGTGGVLLVGAVWQVAAGAVVLGLPAVRDRRWEEGPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC72</accession>
    <name>A0A1E7NC72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555039.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000223.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3023"/>
    <dbReference type="EnsemblBacteria" id="ARF79716">
        <property type="protein sequence ID" value="ARF79716"/>
        <property type="gene ID" value="B6264_13095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38073">
        <property type="protein sequence ID" value="OEV38073"/>
        <property type="gene ID" value="HS99_0023005"/>
    </dbReference>
    <dbReference type="OMA" id="AYVRMRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="18943" checksum="6F85FE81B58FC81C" modified="2017-01-18" version="1">MHLRNVEPGDAEAYVRMRCDEGMMAELGGPLPREKVEARLRKDLALVAADSAWIKVIVPDGDAGPGGAAGLVTLWQDEEDGVTVSEIGWMVLPGFQGRGLAKAAVRQVLDAAAADGRWGEVHANPGVTNGPSNGICRALGFRLLGQRDLDFADRILRTNHWVVTPGRHDGARAGSGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE9</accession>
    <name>A0A1E7NCE9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388389.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4168"/>
    <dbReference type="EnsemblBacteria" id="OEV38357">
        <property type="protein sequence ID" value="OEV38357"/>
        <property type="gene ID" value="HS99_0022510"/>
    </dbReference>
    <dbReference type="OMA" id="CLAVTTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="261"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="484" mass="49148" checksum="18CAB08E4E8312B6" modified="2017-01-18" version="1">MRWALIKAAAAGTTMVALAFLIPLGLMVQQTARERAFTAAERQAAALGPALAITTEQDAIDRAVASTDAGAQGRMAVHLPVPAGAVGAGGAGAGVAGAGRAAGEGPGGPTIGEGRATAADVATAGGQGRAFTVAVPGGYALLQPVAVDTGRTAVVEVFVAESDLTRGVSTAWLVLSAVALGLVAVSVLVADRMGGRIVASARRLAAAARSLGAGNLAVRLPVEGKQVDGSPEELREAAHAFNTMADRVVQLLAAERELAADLSHRMRTPLTVLRLNAASLGHGDAADATRHAVAQLEREVDQIIRSARRAPEDAPAVAVGCDAAEVIRERVGFWSALAEDEGRRWQLAGAERPAPVPVQRGDLAAAVDALLGNVFRHTAVGTAFSVDVLATDGSVIVLVGDAGPGYSDPAAALRRGEGHGGEGSTGLGLDIVRKLAESTGGDLALGRSAVLGGAETTLRLRTRPEEAPPVRIGRRRTRGALFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM5</accession>
    <name>A0A1E7NCM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287723.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene305"/>
    <dbReference type="EnsemblBacteria" id="ARF82173">
        <property type="protein sequence ID" value="ARF82173"/>
        <property type="gene ID" value="B6264_27805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38435">
        <property type="protein sequence ID" value="OEV38435"/>
        <property type="gene ID" value="HS99_0021250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15188" checksum="37CA1038D37F0F10" modified="2017-01-18" version="1">MSANSRFGLSSPIARRFKGAVAAAVMAGVTIAVPVVSAGSAEAATANSPAALQKLAAQIVPANQLASFDQIISHESGWRVNATNPSSGSYGLPQALPASKMASAGSDWRTNPSTQLRWALKYMNGRYGSPNQAWVFWQNHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP5</accession>
    <name>A0A1E7NCP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aliphatic nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385928.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene336"/>
    <dbReference type="EnsemblBacteria" id="ARF82146">
        <property type="protein sequence ID" value="ARF82146"/>
        <property type="gene ID" value="B6264_27655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38457">
        <property type="protein sequence ID" value="OEV38457"/>
        <property type="gene ID" value="HS99_0021395"/>
    </dbReference>
    <dbReference type="OMA" id="CVEPKQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="PTHR46044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="35093" checksum="ACC32E489C3577B8" modified="2017-01-18" version="1">MLDLPRFTAAAVQAAPVYLDPAATVDKAVALIQEAARHGAGLVVFPEVFVPGYPYWNWTMTPVQGSPWYERLYRAAVNVPGPYVDTLRAAARQAGVVLVIGVNERGRHSLGVLYNTLLVIGSDGELLGVHRKLVPTWAEKLTWTPGDGSSLRVHRTAVGPLGALACGENTNTLARFTLLAQGELVHAASYIALPVAPEDYDMAEAIALRAAAHCFEGKLFTVVSCSTISPEMVDLIAGEDQQVRKQLARPRNALSGIFGPDGRAVTESLVDEEGIVYAEIDLGRCVQPKQMHDIVGHYNRFDVFQLHVNDRPLRPLVLPEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ1</accession>
    <name>A0A1E7NCQ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554511.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene309"/>
    <dbReference type="EnsemblBacteria" id="ARF82170">
        <property type="protein sequence ID" value="ARF82170"/>
        <property type="gene ID" value="B6264_27790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38438">
        <property type="protein sequence ID" value="OEV38438"/>
        <property type="gene ID" value="HS99_0021265"/>
    </dbReference>
    <dbReference type="OMA" id="DGKGDWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="42365" checksum="4BED14A21FC9ABC2" modified="2017-01-18" version="1">MRLRSLAAALAATLLVAATPALADTAQPTTTAPASDCALPGKTGWTDEGHNTDHTQFQQPFGTKHVLMLFVDFPDAPAAGSLDDYYRALAPAQEWMEQDSYGRVRLDIDPLKRWITMPQASATYGFQRGITFEQQELYVKQAAQAAAPYVDFSKYDMLYIVPTKSASAISFSPTYLYDPTTAGITVNGTRIKWAITFGQDMYHWGYKVADHETSHTFGLPDLYAFTGTDVHRYVGGWDLMGNIAGPAPQHIGWERWKFGWIDDRQVACLPATGSRTVRLKAVERPGGTKIAVMRTGGTTAYVAESRRAVGADDTACSTGVLIYKVDTSTQTGYGPVQVVNGNPGATAPAGCAALDMAAYQPGQSFTDPATGVRIDVLRRGPVSDTIRVTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU8</accession>
    <name>A0A1E7NCU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288362.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3100"/>
    <dbReference type="EnsemblBacteria" id="ARF82098">
        <property type="protein sequence ID" value="ARF82098"/>
        <property type="gene ID" value="B6264_27350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38505">
        <property type="protein sequence ID" value="OEV38505"/>
        <property type="gene ID" value="HS99_0021695"/>
    </dbReference>
    <dbReference type="OMA" id="LWQMMLL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="43963" checksum="B5CBBAD3890D1B5E" modified="2017-01-18" version="1">MPTPHPRRLAWASRNFRIQTAATVVSGLGNAGAPIATAFAVLGNGGTTAEVGYVTAARLLPTVLLLVVGGTLADRLPRHRIMVAANLFSAAAQAVLAVLVLAGDVRLWQLLVLSAAGGAGYALYSPAAGGMIMQAVPQEHANRAFSVFRMGQNGSQIGGAALGGGLTAVCGPGWVLALDAFCFLVAAVLRFFLAPEAAPAPSGGSMLRDLREGWREFSSRRWLWVVVAQFAVLVACINAVESVYGPAVADQRLGGAGAWGLAMSAYGVGLVVTGLLMARWRPRRILLVGNWGVFLFGVPALALALEAPLPLLIAAMFLSGVGVTVFAVNWMVALQQEVPEEMFSRVTAYDELGSYSLAPVGTALAGPAAVALGLSGALWACAALCLVLSAVVLIDPQVRRLTRRDPRRSSPDAPVSAVEPAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY8</accession>
    <name>A0A1E7NCY8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281300.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77590">
        <property type="protein sequence ID" value="ARF77590"/>
        <property type="gene ID" value="B6264_00415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38566">
        <property type="protein sequence ID" value="OEV38566"/>
        <property type="gene ID" value="HS99_0020000"/>
    </dbReference>
    <dbReference type="OMA" id="GYADKSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="42482" checksum="D33CD4D50A6BC229" modified="2017-01-18" version="1">MVEIWGETAEGFEPVREAFARNFAEYGELGAAFALYVRGRKVVDLWGGDARPEVGGRPAPAVPWTADTAQVLRSVTKGLTAATALLLVERGLLDLDAPAASYWPEFAAAGKGAVPVRWLLSHQAGVPALDVPLRLEDVLTWERAVAAVAAQAPAWEPGTAHGYHPYTFGWLVGEVVRRVSGRTVGQYFAEEIARPLGLDLWIGLPAGAAPRVGKLVDLPAPEAARTGPSGLRLRPKQSVRDAYQDPTSLTARAFASVLPGVNMNDPAVQAAEIPGAGGIGTARSVARFYAALIGAADRPDGSGALLPPLFGPEVLARAVGPVVNGPDRVLIVNSTFGLGFWRHGPTAPMTSPTSFGHPGRGGSLGFADPELGLGFGYVTNGMQPGVTGDVRSRNLIRAVRGCLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND35</accession>
    <name>A0A1E7ND35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366431.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene632"/>
    <dbReference type="EnsemblBacteria" id="ARF77624">
        <property type="protein sequence ID" value="ARF77624"/>
        <property type="gene ID" value="B6264_00650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38597">
        <property type="protein sequence ID" value="OEV38597"/>
        <property type="gene ID" value="HS99_0020235"/>
    </dbReference>
    <dbReference type="OMA" id="AYGLFFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="33899" checksum="0FBCF40B943324DD" modified="2017-01-18" version="1">MTSPASPPPATTPDSSTSAIPSTAPAPSPARLSGAVWLALAVVYVVWGSTYLAIRIAVETMPSFFSAAARFLTAGLLLVGYLLVRQGPAGLRVSGRQLASAALVGVLLLTGGNGLVVLGETSVPSGLAALLVAAVPLWMVVLTAVGGGERPRRAELAGVLLGLVGLGVLSAPAIGGSVEPLGVVLIICATLAWAAGSFASKKIPMPGNVLAASAYQMLAGGLCNVLIGLARGEQHGLDLGAVSGRSWLALAYLVLFGSLLAFTAYAWLLRSAPLTLVATYAYVNPVVAVLLGWLILAEPLTGPTLAGGSIVVAGVCLVVSVSRRQGRPSKAGAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH4</accession>
    <name>A0A1E7NDH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286313.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000495.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7318"/>
    <dbReference type="EnsemblBacteria" id="ARF81145">
        <property type="protein sequence ID" value="ARF81145"/>
        <property type="gene ID" value="B6264_21555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38737">
        <property type="protein sequence ID" value="OEV38737"/>
        <property type="gene ID" value="HS99_0018825"/>
    </dbReference>
    <dbReference type="OMA" id="VLRGWGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="30809" checksum="D321F3FAB59F72FF" modified="2017-01-18" version="1">MTTTLRPEGPETPTTAGGRTRRWRILSNGHQVGALRTTSARHGTQLWGEISELEITEARGRGRGTFGALAAEEVLRNWGCARVDVVVPESAQAARGLAATLGYAERMRNLGKSLTAAPPLPGGVTARPIGAAEFPAWLDRAARAYVRSLMDSGLTEEQARAKSRLDHHNVLQQGADTPGVVLRRLYRAGGDDRAAAEPLGSLWVDLHLRDLPDGTPLAWVMVVEVSPAHRGRGHGRTLMLLAERECLAAGVRELGLNVFSGNEVALRLYASLGYRVVNRCYGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDP1</accession>
    <name>A0A1E7NDP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000233.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6262"/>
    <dbReference type="EnsemblBacteria" id="ARF81215">
        <property type="protein sequence ID" value="ARF81215"/>
        <property type="gene ID" value="B6264_22010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38810">
        <property type="protein sequence ID" value="OEV38810"/>
        <property type="gene ID" value="HS99_0019275"/>
    </dbReference>
    <dbReference type="OMA" id="CMAPAPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21108" checksum="3FE13EE922DE494A" modified="2017-01-18" version="1">MFRTTRTARSTRTAVAAALGALALTALTAAAPAGATPSTETTAAARVNGSARIHYAPSPNDDIRFTIDAEGVPYTHPVPGLPTGLPTDARGTVHFSHRTASGDFREADATVDCLATGGPVATLSAVITKSNGIPVGERIGLSIYDAHGHGRDRLGFSWGVANMDLDKDGNPYQPVVGTCMAPAPFAPVTRGTFTVHSVELTDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ8</accession>
    <name>A0A1E7NDZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287243.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6508"/>
    <dbReference type="EnsemblBacteria" id="ARF83003">
        <property type="protein sequence ID" value="ARF83003"/>
        <property type="gene ID" value="B6264_22380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38931">
        <property type="protein sequence ID" value="OEV38931"/>
        <property type="gene ID" value="HS99_0019645"/>
    </dbReference>
    <dbReference type="OMA" id="WSTRYMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21546" checksum="1075D4C679105836" modified="2017-01-18" version="1">MTYGAGSSANSCTDCPNPGGGQFYTDLNALGLSALAQGRTLDLKYSVRFPAGRDWGKAGKLPGLYGGKIGEESGGNHGAGWSTRYMWRAAKGSPDNGEVYLYTPSNSGPTGYGVDEGLGDWHFQADDRWHTVEQLVDRGTGDITVWYDGRQVHAAKGTASGIGSIPFGGVLFSTFYGGHDTSWGPASTQQAYFADFSLSAGVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF57</accession>
    <name>A0A1E7NF57_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284972.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000389.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39278">
        <property type="protein sequence ID" value="OEV39278"/>
        <property type="gene ID" value="HS99_0000750"/>
    </dbReference>
    <dbReference type="OMA" id="NDWQGSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="555" mass="59679" checksum="1EFF2EBAEDEBEA8F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF72</accession>
    <name>A0A1E7NF72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3667"/>
    <dbReference type="EnsemblBacteria" id="OEV39322">
        <property type="protein sequence ID" value="OEV39322"/>
        <property type="gene ID" value="HS99_0000995"/>
    </dbReference>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="27463" checksum="74066F00C0E840C4" modified="2017-01-18" version="1">MADQMLLAAQRQALILEAIRRAGAVRVAELVEQFGVSDMTIRRDLDALVRQGTVEKVHGGAVATGTASTFEPGFDAKSGLEEGTKAALADAAVKLVEPGSVVALSAGTTTYAVAARLLEVPGLTVVTNSLRIADLLWAAGSDGRETVPSLLLTGGSPTRSAALVGALADQTIRSLHVDLLILGVHGVSEQAGLTTPNLAEAQTNRALIASARRTVVVADHTKWGVVGLSSFATLAEVDCFVTDDALPATARELVAEAVGELVVVPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD9</accession>
    <name>A0A1E7NFD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7530"/>
    <dbReference type="EnsemblBacteria" id="OEV39419">
        <property type="protein sequence ID" value="OEV39419"/>
        <property type="gene ID" value="HS99_0001590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14487" checksum="A388F898C2EBC1BF" modified="2017-01-18" version="1">MNEELAELAASGATALVAAMGTDLWTEAKRLMSGVVARAHGGRRRELSAALELPSTTTRGVVDGEAVSYWTDALVQLLHRNPGLAQDVMALASLRIPRQPDVAVQVNSATGSGEVFAVQHGNQHFAGGPRSRDSGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG5</accession>
    <name>A0A1E7NFG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288836.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1551"/>
    <dbReference type="EnsemblBacteria" id="OEV39375">
        <property type="protein sequence ID" value="OEV39375"/>
        <property type="gene ID" value="HS99_0001310"/>
    </dbReference>
    <dbReference type="OMA" id="FATTWIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="23272" checksum="36D0E200DB877C29" modified="2017-01-18" version="1">MLLIRPPGVYPPQGDTALLADCVRRESLDDSSRVLDLCTGTGAVALVAARSGARVTAVDLSARAVVTAWCNTRLHRRRIRLRRGDLLVPVTGRRFDLVTANPPYVPTASGIRSPGRGAALAWDAGADGRLVLDRICRTAPRVLASGGVLLVVQSALADVPATLAAMRRAGLRAGVAARRRQPFGPVLTARAALFEQLGLIRPGEREEELVVVRGVREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ9</accession>
    <name>A0A1E7NFJ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5084"/>
    <dbReference type="EnsemblBacteria" id="OEV39481">
        <property type="protein sequence ID" value="OEV39481"/>
        <property type="gene ID" value="HS99_0001955"/>
    </dbReference>
    <dbReference type="OMA" id="RQGHEYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="103"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="37738" checksum="EAE7BAE334ACC56A" modified="2017-01-18" version="1">MRRDGRVADSLLALLSRDWLGVPVAVLVVGVGGALVGKGAAWAVALGGIVVAVGVLLGAGAVRHLVLVAREARVNPPPGRLVDVGGHRMHVLAEGEAGGGPTVVWMPGGHAPGEDFRELHTMLAARTRSVLVDRFGAGWSDVGPFPRTTAAEAEELLTALEGAGERPPFVFVGHSFGGLLVANAARRRPDLVAGLVLLDPTPLEVIAFAPRNRQLAGMRRGFLLTAVRQLFGAHRGPGCRTGQGCAAASVFAELSPSGLARVGWETVVYDEDLGDLPLVLVIPRDLIGGEAVLAGARDAVEAERLARFYLRSRVRYLAASSASRLVHTPEGTGHDFPHEAAEFVVGVVGELVRELRTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY7</accession>
    <name>A0A1E7NFY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279158.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2729"/>
    <dbReference type="EnsemblBacteria" id="OEV39597">
        <property type="protein sequence ID" value="OEV39597"/>
        <property type="gene ID" value="HS99_0002675"/>
    </dbReference>
    <dbReference type="OMA" id="EEMYTLC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28781" checksum="D92DA93A539B3B5A" modified="2017-01-18" version="1">MEQPTTADADPVRVLETSGTDYRRAFDLFLAGTDEKPRTHARLSEIATSLPHRRVLLDLGAGDGRTTAYLARHFERTIAVEPSAAMREKLAAACPDALVIPHPLDRAAPPEPADLVHLSHVLYYVPQPDWLPTVARALGWTAPGGAMLIVLQNPDSPCMRMAAHFTGVRYDLRPLLDRLRAQHPAHDYALETLALHYRTPHLTEAVDVAEFMVNVADLATLDARPTRAALAAYVQQHFARPDGGYAIGHTQDMLIVRRAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ9</accession>
    <name>A0A1E7NFZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481126.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6722"/>
    <dbReference type="EnsemblBacteria" id="OEV39568">
        <property type="protein sequence ID" value="OEV39568"/>
        <property type="gene ID" value="HS99_0002495"/>
    </dbReference>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="36209" checksum="FBACF7DCF1C4F80F" modified="2017-01-18" version="1">MDTTRLVAGETGAWVVAQPGPVGGAGPGPLEWERRPVPEPGPGEVLVEVEACGVCRTDLHLAEGDLSPRVARCTPGHEVVGRVRAVGSAVGGFATGDRAGIAWLARTCGSCAYCRSGRENLCPRSRYTGWDRHGGYAGHLTADARFAYRLPEGPPAEELAPLLCAGIIGYRALERADLPPGGLLGIYGFGASAHLTAQIALARGSRVAVFTRGEAARQLALDLGAAFAGDSYDPAPEPLDAAILFAPAGELVPVALTALDRGATLAVAGIHLSDIPPLDYQRHLFQERTLRSVTANTRDDGRAFLAEAARTRPVVHVNRYPLRQAGTALADLAADRVTGVAVLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG34</accession>
    <name>A0A1E7NG34_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279223.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000789.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2768"/>
    <dbReference type="EnsemblBacteria" id="OEV39632">
        <property type="protein sequence ID" value="OEV39632"/>
        <property type="gene ID" value="HS99_0002870"/>
    </dbReference>
    <dbReference type="OMA" id="VEVWRHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19562" checksum="0CA50219A59AAA6F" modified="2017-01-18" version="1">MLLDDASAEFHDFFERHYAELARLAHLLTGETDAADDLAADALVALWQRWDRLRAADHPVAYARGVVANMARERIRSAVRERRRVLLFWSRSPERTSGPDVAAVLDVRAALARLPFRKRACVVMRHAFDLSEKDTAAALGISVGTVKSQTSKAMAELEQLLGARAVGELTAGRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG73</accession>
    <name>A0A1E7NG73_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0003145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385609.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2823"/>
    <dbReference type="EnsemblBacteria" id="OEV39674">
        <property type="protein sequence ID" value="OEV39674"/>
        <property type="gene ID" value="HS99_0003145"/>
    </dbReference>
    <dbReference type="OMA" id="YHDIDYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="611"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="442"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="712" mass="77969" checksum="8410903790168EFB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA3</accession>
    <name>A0A1E7NGA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron export ABC transporter permease subunit FetB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0003570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279517.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000745.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2910"/>
    <dbReference type="EnsemblBacteria" id="OEV39741">
        <property type="protein sequence ID" value="OEV39741"/>
        <property type="gene ID" value="HS99_0003570"/>
    </dbReference>
    <dbReference type="OMA" id="PWYEPQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="PTHR30028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00245">
        <property type="entry name" value="TIGR00245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="26344" checksum="DB6C91734454A493" modified="2017-01-18" version="1">MNTAVPTWAGVAASIALVLPAIAVAWHRRLDLARDIAVAAARAGVQLAAVGAILLLVFQHTGVAGAAGCLALMVITAGRVCAGRSAGLPRALPIATTAVAVGSGATLGVLLALGVIAPQARVVIPVGGMVVSGAMQATTLLLVRLRDEARTARPAIEARLALGLPAVEAFAPHLRSTLRTALIPAVDATRTVGLISLPGAMTGLILAGVDPLTAIRYQIVVMYMMLSAAALAALTAAHLAERALFDDVHRLRPLTAGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD9</accession>
    <name>A0A1E7NGD9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0003700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367077.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2937"/>
    <dbReference type="EnsemblBacteria" id="OEV39766">
        <property type="protein sequence ID" value="OEV39766"/>
        <property type="gene ID" value="HS99_0003700"/>
    </dbReference>
    <dbReference type="OMA" id="WKMILIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="450" mass="47153" checksum="42EA7FC61CAEDF72" modified="2017-01-18" version="1">MTDHIETAPARDGVQDGGRRRELAAATVGSVVESFDWNVYAVLAPYFAADLFGHGKGGVSGVLAAYATFAVGFVARPVGSYLIGRLSDTRGRRFALSLGMAVIAVASLGIATLPGQRTIGAWAAVLAVVVRVVQGLAFGGEAPSVAAYVTETAPPRHRFAFSSVSYGGIILGSLLSFGVLTLLIHTIGKSGLENGGWRWGFLVAALLGLGALWVRRAAPESAEFHRARARVRPGARPSFLRTVRDHRWAVLTVFLNTLGGTVGYYFALTYLPQYAAAYHVIDKERAASFMTVVLAIVLATMLLTGAAADRFGLLPVARIGFGLPIPLVGILLAGLRGGWLPFQVVAVLLGMTVATVLGTLNVFTGLLFPTEVRAVGLGVVNAATIAAFGGTFPLLAEWLDHHNGLGVIPVYVTVCTAGPALGLLTAMRVPSFTAALRQAEPDVQRPPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGE9</accession>
    <name>A0A1E7NGE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480319.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3545"/>
    <dbReference type="EnsemblBacteria" id="OEV39789">
        <property type="protein sequence ID" value="OEV39789"/>
        <property type="gene ID" value="HS99_0000410"/>
    </dbReference>
    <dbReference type="OMA" id="MIMMPVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="46734" checksum="04C44CB5DFC3D280" modified="2017-01-18" version="1">MWKMGVVLALGPILALLDTTIVNVGIDSVARDLRSSMVGVQWVATGYLLAISLTMPLSGWAAGRLGARRAWLGSVVLFVLGSALCGLAWSTGSLVAFRVLQGVGGGMIQPLGQTIMVQAAGPIRIGRVMGTLLLPISLAPVLGPILGGVVLEHLGWRWMFLLNVPVGLLTVLLAARWLPTGARSELPRPRLDVTGLLLLSPGLTALVYGLSTVGGGGAASPVAVAAGTVLLAAYGPHALRVGRCGERAPLIDLRLFARRGFAVATANSFLQGAVLYSSMFLVPLYYQQVEHTGAVAAGLLLAPQALGTAVTSLLSGRIADRFAPRPLILIGIGCSLLGTLAFTQLGDGSGPADWLVVGSLALRGVGMGITVIPGMAAVYASVEKAQVPAAAGAVNVLNRLGGALGTAVLTLVLGQVQAGHPDHPGAAFGATFWWVLALSALSIAPAMLYPGSARTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGR7</accession>
    <name>A0A1E7NGR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387114.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000678.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2724"/>
    <dbReference type="EnsemblBacteria" id="OEV39848">
        <property type="protein sequence ID" value="OEV39848"/>
        <property type="gene ID" value="HS99_0002650"/>
    </dbReference>
    <dbReference type="OMA" id="FPPQRVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="40847" checksum="7D1A53E6FEF7B073" modified="2017-01-18" version="1">MTSPIRRLLAGRTLAALATALIPTTLTLAVVRTGSATDLGLVLSCELLPMLVLLPVAGVVADRFPPQRVVFTADLVRATAQLAIGAELLGGGLRIPDLAVLSAITGAAVAFGTPAVRTLVAAVVTGAERLRTNAQLGAAQGLAQIAAPAAAGGLMLLVGAGWSSLLTGALFIASASTLGGLRPDRSLQRAERSAFLGELREGWAETRRHPWFLANVLGHGVWHLTAGVLLTLGPLITVRHLGGDTAWVVIAEVGTVGTVAGVYAASRLPIRQPLVGVAVGAAVFALPLTAFALLLPVPVVTAAYFAGMFGVGVLNPLWETTMQRRIPPEALGRVGSFDTLISFAARPLGLAVAAPLAAGIGTTTPLLLGAALVGTANLAVLLLPTVRETTRAPLPAAEQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV10</accession>
    <name>A0A1E7MV10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-(3-hydroxyphenyl)propionate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279657.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000240.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32271">
        <property type="protein sequence ID" value="OEV32271"/>
        <property type="gene ID" value="HS99_0016275"/>
    </dbReference>
    <dbReference type="OMA" id="HHTSAQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="489" mass="52246" checksum="127F980AF5942BD5" modified="2017-01-18" version="1">MDTDVLVVGAGPTGLTAANELLLAGASTVLADRLPQPSALSRAGGMQSRTVEALDQRGLLEPLLTTGHHPVGTSHFAGIPLPADDDSRPRLPWRSVPQVELEGFFEKHLAAQGLHVRRDHELVGLAQDEEGVTASFANGRTVRARYLIAADGGHSTARSLLKAEFPGRAGTATTIAADVRLSGTEQLGTHHRAEDGTWAAVFPLGTDGRGRPLRRLALGGPGRSVPRDVPITEEEIRTGLRAVFGERVQLLELRHARRITNAARQAAQYRHGRVFLAGDAAHVHLPLGAQGMNSGMQDAFNLGWKLGAAVRGWAPEGLLDSYHTERHLAGALVLRNVQAQSLLMDWTGSGDPEVTAARELFTELAELPEVRRRLGDLMAGTAIRYPMPDAAPHPLLGGPAPDVDLGPTRLHELLRSGRGVLLDPRGDLAGTVAPWSDRVDRFGRTGRADRGAVAAEPMLVRPDGHVCWVGVSESLRPSLARWFGAPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV26</accession>
    <name>A0A1E7MV26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenylalanine 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0016315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000133.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2985"/>
    <dbReference type="EnsemblBacteria" id="OEV32279">
        <property type="protein sequence ID" value="OEV32279"/>
        <property type="gene ID" value="HS99_0016315"/>
    </dbReference>
    <dbReference type="OMA" id="KQFPVAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016714">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="PTHR11473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="SSF56534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BH4_AAA_HYDROXYL_2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="32838" checksum="FC85AAC556A87F47" modified="2017-01-18" version="1">MQCVGETRARTPVAADGRLGVPAEHPGLSDPHYLRRRRSLAAMARGHRVGDPAPLVEYSASEDRTWRTIHRALWSAQEEHACRAVLDAREQAPIPAHRIPQHAEVGPALRRSTGFQFTLAGGVVANKRFLGSMADGYFHAVQFVRHPAVPLFTPEPDVVHDVFGHGIHLSCPAFADIYRSIGRAARRIDDADVLQMISDVYWFTLEYGVLEEDGMPKAYGAALLSSFGEIRRLGLSDVRALDIEAMLTTPYDISGYQPVLFSARCLHEVADTLNGFLEQLDDGSASRFGRTPPGARSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV46</accession>
    <name>A0A1E7MV46_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6874"/>
    <dbReference type="EnsemblBacteria" id="OEV32298">
        <property type="protein sequence ID" value="OEV32298"/>
        <property type="gene ID" value="HS99_0016435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="8826" checksum="A1D201F4BF94A2A3" modified="2017-01-18" version="1">MRVATVRTGGAERLALVDPEGGALALPAADRRRPVGLAELLPAGPEAWAEFAERARSGPRLPFDEADLLAPLPRPRTTCSPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU9</accession>
    <name>A0A1E7MVU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0040155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000092">
        <property type="protein sequence ID" value="OEV32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7190"/>
    <dbReference type="EnsemblBacteria" id="OEV32554">
        <property type="protein sequence ID" value="OEV32554"/>
        <property type="gene ID" value="HS99_0040155"/>
    </dbReference>
    <dbReference type="OMA" id="WWLHRAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="13"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="47890" checksum="2A988F4B5ADE049C" modified="2017-01-18" version="1">MATALHLQRGLRERLRRGEVEITVVEPRAYSTYHPLLAEVAAGSIDPRHVVVPLRRVLPDCRVLTARITRIEHAARRVLADAAGPGEPPAPLEVPYDVLVVAPGSVSRTAPVPGLAEHGIGFSTVGDAVHLRNHALEQLDLASATRDPALRQSALTFVFVGAGYAGVGALAELEDMARTAVRGHHNVRAEDLRWVLVEATDRILAEESPELAEHTLRQLRERGVDIRLRTTLESAAGGIAALSDGSRFGVRTLVWTAGVRPSPMLRDTDLPLDTLGRVRCLATLQAVGPDGRALPGVWAAGDGAAVPDPNADGAPCAPNAQHALAQAALLARNIALALDGGPHAPGLVAYRPVPAACSTSLGLHRAVAHTRRGGRLTGRRAWWLHRARHLRRLPSAERRVRVLMDWVLLGVFSREVVSLGTMAHPRSTLEGGFDSGTGRPAGAEPEAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW3</accession>
    <name>A0A1E7MVW3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0040080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32565">
        <property type="protein sequence ID" value="OEV32565"/>
        <property type="gene ID" value="HS99_0040080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="16795" checksum="1DA199C7A0AFF4F6" modified="2017-01-18" version="1">MAPAQPRRGDPGARAADHRDRHRGRGPRAGHPLDGPDRPAALAGGGHHGGRAAEPRRVGVLLGGSIVDALVGVLIGTGRGAVGHGHGFAFVFVDAEPYGRAVPVGFGRAAVLRTADRYGGALADADGRRVDAPDRGGHGLGTIGGPGRRRAAGRRQVRWIGGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW5</accession>
    <name>A0A1E7MVW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0040010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000088">
        <property type="protein sequence ID" value="OEV32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385591.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000088.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7045"/>
    <dbReference type="EnsemblBacteria" id="OEV32577">
        <property type="protein sequence ID" value="OEV32577"/>
        <property type="gene ID" value="HS99_0040010"/>
    </dbReference>
    <dbReference type="OMA" id="WMLGTPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198474" evidence="2">
        <location>
            <begin position="16"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="24"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="300"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="42657" checksum="76F8DE2D6D208562" modified="2017-01-18" version="1">MLVALIGQAPATATAATTTAATAPVAAAGPPPGWTTVFSDDFSGPAGARPSGANWTYDTGPGSNFGTGEIETMTDSTANVHLDGNGHLDITALGSGGSWTSGRIRTPSAVAGAPAGGKLEVTASIMQPAPAGGLGYWPAFWMLGPGQWPENGEIDIMEDVNARSQVAGTVHCGTSPGGVCNEGNGIGSGLRACPGCQSGYHDYAMVLDRTNTAAESITWYLDGAAYFTVTESQVGTAVWQQAFDHPLSVILDLAIGGGFPNGVCGCTTPTAATTSGATMSVASVAAYTTTGGGSGGGSAITGYGGLCLDDRAASTADYNPVQIYTCNGTPAQQWTVVQAGSTLHVLGKCLDVYAAGTANGTAVDLYTCNNTGSQVWIPRSDGSLYNPQSGKCLDDPGWSTTAGTQVQIWDCTGGANQKWALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW22</accession>
    <name>A0A1E7MW22_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287861.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000296.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3854"/>
    <dbReference type="EnsemblBacteria" id="ARF78327">
        <property type="protein sequence ID" value="ARF78327"/>
        <property type="gene ID" value="B6264_04810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32632">
        <property type="protein sequence ID" value="OEV32632"/>
        <property type="gene ID" value="HS99_0015270"/>
    </dbReference>
    <dbReference type="OMA" id="NCVGMRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="33840" checksum="AA91139044A5080A" modified="2017-01-18" version="1">MTHQPEPLLSGVLAIDAGNSKTDVALIGADGTVLGSARGGGFAPQKVGGAAAVAGLTPLVEQAAAAAGLAGAAGVLTSHVSACLANADLPIEEESLRTALASHPWGLSNTVVNDTFGLLRAGTDGPRGVAVVCGAGINCVGLRPDGRTARFPALGELTGDWGGGSGLAVSSMWHAVRAEDGRGGPTALAPAIAEHFGLPSAGAVAEAVHLGHLPTSRLHEIVRVLFAVAVEGDAVAMELIDRQADEIVRLAVVALGRLELLDSPTPVVLGGGVLASRHPLLLDNLTARLARAAPLAEPRVVVAPPVLGAALLGLDHLGAGGAAQARVREAYEAQRTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW87</accession>
    <name>A0A1E7MW87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3192"/>
    <dbReference type="EnsemblBacteria" id="ARF78264">
        <property type="protein sequence ID" value="ARF78264"/>
        <property type="gene ID" value="B6264_04450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32698">
        <property type="protein sequence ID" value="OEV32698"/>
        <property type="gene ID" value="HS99_0015635"/>
    </dbReference>
    <dbReference type="OMA" id="PCVNAAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="19989" checksum="0073B2D28D0D03EE" modified="2017-01-18" version="1">MVTPEAASSRREPFLYVIVCASGVADGVGELIIAAHAEGWKVGVIATPNALGFLDQEAIEAQTGYPIRSAWRTPGGSRPMPEADAIAVVSATFNTINKWALGIADTLALGILCEAYGLGIPVVVQPYVNSALAAHPAYSESLVRLRSMGVLVGDSVPHQPRSGGARDEYSWTYVLDLLRPTLSSLSEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWH5</accession>
    <name>A0A1E7MWH5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287945.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3809"/>
    <dbReference type="EnsemblBacteria" id="ARF78369">
        <property type="protein sequence ID" value="ARF78369"/>
        <property type="gene ID" value="B6264_05040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32593">
        <property type="protein sequence ID" value="OEV32593"/>
        <property type="gene ID" value="HS99_0015040"/>
    </dbReference>
    <dbReference type="OMA" id="EIRFFEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="32608" checksum="E251D35F8A191893" modified="2017-01-18" version="1">MELRQLRCFVAVAEELHFGRAAERLLLGQPAVSQQVRRLERELKVELFDRSPRYVRLTPAGERFLPAARDVLSAEDAARALAADLAAPAVLRLGTVTGLAERLDLILDTYQRQAPGVRVELQSVPVRERLTRLSDGRLDAAFVRGAIPGNSPELRFLPVWDDELVVVLPARHALAQQPEVDLADLAALPLRLTDRRNNPALVDLVTDACAQAGFRPVLGPAHGALQDTLASIGTGTPMWTVVYAANARLTNSPRVAFRPCRTPLSLPTSLAVRRSAPLPRLLLAACRKTPPSWDDQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV6</accession>
    <name>A0A1E7MWV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552583.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81332">
        <property type="protein sequence ID" value="ARF81332"/>
        <property type="gene ID" value="B6264_22655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32922">
        <property type="protein sequence ID" value="OEV32922"/>
        <property type="gene ID" value="HS99_0013640"/>
    </dbReference>
    <dbReference type="OMA" id="WMAGWYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="30446" checksum="7143A912398A1E51" modified="2017-01-18" version="1">MNKSEKIISDARKGNFLADLPDLLEIATRKGGARGPVWEAAAAAVQILFWTGEFAQAADLTQDLIERDGPLGGELCDQSTPFRPALLAGQLYADEPAAPRLAACAERIPDGRYMRRDFEWLSQELPRQGVEPLLPCHSDWGGAVRPLDGVIGAGLVDRNYHELDRKQRRLVWEALSETNDFTRAHQLLTDTGEEPEQYSICLWMAGWYATRGEVEHGEQMLLAAHSRWWPFAKWDAIPDAPVLQPTLRLVVTDKVRDHYLTRPIGPEAQAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY7</accession>
    <name>A0A1E7MWY7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0013790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279974.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000916.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5763"/>
    <dbReference type="EnsemblBacteria" id="ARF81362">
        <property type="protein sequence ID" value="ARF81362"/>
        <property type="gene ID" value="B6264_22815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32952">
        <property type="protein sequence ID" value="OEV32952"/>
        <property type="gene ID" value="HS99_0013790"/>
    </dbReference>
    <dbReference type="OMA" id="GYYCSLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="688" mass="73369" checksum="145F4A7AA0DDF0EF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH9</accession>
    <name>A0A1E7MXH9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5730"/>
    <dbReference type="EnsemblBacteria" id="ARF83008">
        <property type="protein sequence ID" value="ARF83008"/>
        <property type="gene ID" value="B6264_22980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33148">
        <property type="protein sequence ID" value="OEV33148"/>
        <property type="gene ID" value="HS99_0013950"/>
    </dbReference>
    <dbReference type="OMA" id="WLRYPTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18110" checksum="D7EC5129B9BCB349" modified="2017-01-18" version="1">MSADLTPVIAAGTRWLLTAFPPAPGAFSRALAEAQAGQAVTLAAVLRYPTDLDAQLLHLLGPGGSARLDWLTGAEHDRPAEDTAWRTWVDETVVSWAACLLADPALVPLAQAAAAAAGAGATGAVTRLLRPGDHEHQAAPLLRHPDLLEPIAALHREMLLHRLQEENLPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ3</accession>
    <name>A0A1E7MXJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4231 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000916.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83007">
        <property type="protein sequence ID" value="ARF83007"/>
        <property type="gene ID" value="B6264_22820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32953">
        <property type="protein sequence ID" value="OEV32953"/>
        <property type="gene ID" value="HS99_0013795"/>
    </dbReference>
    <dbReference type="OMA" id="NEWANIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17820" checksum="9015546B140010BA" modified="2017-01-18" version="1">MHPNTGPGVGLTPTETAALLLDKIRQGQDYARGKKEKFRRRASVIKMLTLALSAASTILLGLHRWTDLAFALVALVTALAAAEPFFNWRSRWVLMEEAQYRFRRLADDLEYLVASTDPADLARRQLDGVFDRYQAVWEDLSRTWLEQRREAVPSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL5</accession>
    <name>A0A1E7MXL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene17"/>
    <dbReference type="EnsemblBacteria" id="OEV33185">
        <property type="protein sequence ID" value="OEV33185"/>
        <property type="gene ID" value="HS99_0039485"/>
    </dbReference>
    <dbReference type="OMA" id="RMRFSYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="263"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="665" mass="73889" checksum="FB0FBCD354F3517A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ4</accession>
    <name>A0A1E7MXQ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5902"/>
    <dbReference type="EnsemblBacteria" id="ARF82066">
        <property type="protein sequence ID" value="ARF82066"/>
        <property type="gene ID" value="B6264_27140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33228">
        <property type="protein sequence ID" value="OEV33228"/>
        <property type="gene ID" value="HS99_0039095"/>
    </dbReference>
    <dbReference type="OMA" id="HPPVELH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27406" checksum="927A1EBF99B2DECD" modified="2017-01-18" version="1">MLTIAHLSDIHLGQVHRRDAGKRARRRAEQVMAYLDALPGPLDAVLVTGDLADHGLPEEYRQAAEVLASRHPVLTCPGNHDSRAPYRQVLLGEEPTTDPVNRLHQLPGTDVLMLDSSIPDQHDGLLDDATLDWLDAQLGSGRQELPALVAFHHPPVELHVPFVDGIRQFGEERLAQVLHRHPRVAALLCGHAHTSAATTFAGLPVLVAPGVVSTITLPCEGGKGILFDHPPMLAFHVLDGGRLTTHYRVVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT6</accession>
    <name>A0A1E7MXT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367100.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000070.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene171"/>
    <dbReference type="EnsemblBacteria" id="OEV33257">
        <property type="protein sequence ID" value="OEV33257"/>
        <property type="gene ID" value="HS99_0039010"/>
    </dbReference>
    <dbReference type="OMA" id="HSMGARA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="238" mass="25032" checksum="602996EA6894D42B" modified="2017-01-18" version="1">MRWRVRPSAVRAAVLVLHGGEEHNLARPRPLNLPLLRMHGFLRALTRATAGTDIALGTVRYRHRGWNGARADAAQDALTALDELAANLGPVPTVLVGHSMGGRAALRAGGHPAVTGLVALAPWCPAEDPCDHLAGRDVLLLHGDRDTVTPPADTRAFAARSRAAGARVCGYTVTGSGHAMLQRIPDWHRATTRLTAALLGLHPLPAEAASALALPPTSPEALTLPLPRQPRPTLAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ1</accession>
    <name>A0A1E7MXZ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3286"/>
    <dbReference type="EnsemblBacteria" id="ARF80293">
        <property type="protein sequence ID" value="ARF80293"/>
        <property type="gene ID" value="B6264_16490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33302">
        <property type="protein sequence ID" value="OEV33302"/>
        <property type="gene ID" value="HS99_0038815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="42827" checksum="AEC6A8CE6C6216C4" modified="2017-01-18" version="1">MLGMPLLLFDLDNTLLPRDAAFRAWAQDFLSEHRLPPRDLDWFVTLDGGGYVPRSTVLSAVRRRYGLDASVDFLLAHFRRGINSHIHCPARHIEALRTARAAGWTLGIVSNGGTRPQLEKIRRTGLGPLVDGWVISEEADCVKPDPLIFEIAARRCGIRPVGDWTAHTWMVGDHAPADIAGAELAGLRSVWLHHGRPWAENGYRPTLKAAGLPEAVGLVLAARNAPSVRPGVREGGLPGVLPAALPAVLPAALPMGLPTVRRDGAGRQQAAGAPVRATAPLGARSGVRPAVAAPEGPNAPVALNAGPAAASASGAGFGVRNRSGEFAVIADGLPDEGEPRESRAGTGGGGTDPGVDGGRTAALARPTPLRTVAGGTGGASGTNGTGPARTVFAAEPSAVTPLAAALTEPLTAAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI6</accession>
    <name>A0A1E7MYI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5187"/>
    <dbReference type="EnsemblBacteria" id="ARF80613">
        <property type="protein sequence ID" value="ARF80613"/>
        <property type="gene ID" value="B6264_18415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33510">
        <property type="protein sequence ID" value="OEV33510"/>
        <property type="gene ID" value="HS99_0013195"/>
    </dbReference>
    <dbReference type="OMA" id="TIWNQTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="46223" checksum="FBD61CCD2DDFEEB4" modified="2017-01-18" version="1">MNDDEPAHTGRPRALLRSLAPDLAPWRASRDFRYLWTSGCVTSFGSFLTYVALPMQIKELTDSSFAVGLIGAVELVPLIVFGLWGGALADALDRRKLVLRSEAALGLLAGLLLLNALLPRPVLWPLYLVAALVAACDGLQRPALDSLLPRIVAHQHLTAAFALKSLYHNVASVAGPALAGVVVAFSGVQTAYALDVLTFVVSLLLLARIRAVPPPTGAERPSVRAVLTGVRYAWSRKDLLGTYAIDTCAMLFAFPVAVFPFLASELGANWALGPMYAASAVGGLLVGATSGWTSRVHRHGRLLVVAAVGWGAAMTLAGLAGNVWVVLLGLALAGGADQVSGIARSTMWNQSIPDEVRGRMAGVELLSYSVGPQLGQVRAGTMAGLIGVRAAVWTGGLACVAAVLTVAAALPRLLAHDDRTDPHTAAVRAAHERAQQEAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYL5</accession>
    <name>A0A1E7MYL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549944.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5207"/>
    <dbReference type="EnsemblBacteria" id="ARF80631">
        <property type="protein sequence ID" value="ARF80631"/>
        <property type="gene ID" value="B6264_18515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33527">
        <property type="protein sequence ID" value="OEV33527"/>
        <property type="gene ID" value="HS99_0013295"/>
    </dbReference>
    <dbReference type="OMA" id="PMYLQLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="510" mass="52833" checksum="91A3F79422561135" modified="2017-01-18" version="1">MANATSQTGEAVADEAGGPAGFTHRQIITALSGLLLAVLLAALDQTIVSTALRTIGDQLHGQTVQAWVITGYLVSSTIAMPFYGKLSDIYGRKPLYLAAIAVFIVGSAACAMANSMETLAIARVLQGFGGAGLMSLPTAVIADLAPVRERGRYFSYLMMAWVAASVLGPLVGGLFAGAGEILGVTGWRWAFLINVPLGLVALLSVRKALNLPHRRVDHPIDFRGALTLALCLVPLLIVAEEGLDWGWGSARSLTLFAVSLIGLVLFVLAERARGLEAMVPLRLFRRGGITMATAVNFTIGVGIFGTVSTLPLFLQLVQGRSATVAGLVIIPVMTGAIVSQTICAKIIKKWNRYKKPAIVGLGSMAGALLSLSAAGADTPLAVIVVIAAWLGFGIGLSQTVITLAIQSSAPKSELGVANAASGLFRQLGGTSGAAVFMSVLFGVAAGRLDGADPDEAVRRALSDPGSTGGLSASAVDAFTSGFDTMFLVGGLILAVGFLLTFPLRELRDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP9</accession>
    <name>A0A1E7MYP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5251"/>
    <dbReference type="EnsemblBacteria" id="ARF80670">
        <property type="protein sequence ID" value="ARF80670"/>
        <property type="gene ID" value="B6264_18730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33565">
        <property type="protein sequence ID" value="OEV33565"/>
        <property type="gene ID" value="HS99_0013510"/>
    </dbReference>
    <dbReference type="OMA" id="VCENREY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7756" checksum="C9C0B568DD137D98" modified="2017-01-18" version="1">MQMQVRIRSVGAALRFAESVLLAPGQRHARRNAWAAVCENREYAADRRHDALGSSRASAGAAPAPGARSVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV3</accession>
    <name>A0A1E7MYV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558208.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000283.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77523">
        <property type="protein sequence ID" value="ARF77523"/>
        <property type="gene ID" value="B6264_00015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33630">
        <property type="protein sequence ID" value="OEV33630"/>
        <property type="gene ID" value="HS99_0038700"/>
    </dbReference>
    <dbReference type="OMA" id="HARERMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="35013" checksum="9236AA5CA2D43823" modified="2017-01-18" version="1">MKGDAVLVELCERLPVLAGEYGLHMVPAVPEDHPGRAEVDGEAMTVDEFCGLARAAGARVLFHRTTAFDADAFLAGAFPEDDDDPDALSEAETASVKAVERVRRRARRHDGQIVDVQLCVVLDGVAVFWSRLASWAAALADDAEKAQDEKNDMVEQIRTSRARDEQAEVTRISRLLQDDPTFREAKDPQARRRAADRLVPRPDEMDFEARRIRTRAIQEAISAIEEAADAIFSEYMTQLPELADELVASGALDGARTIPARKVHLKEFLRKRSGGHTPPVDLITLMMELPQLRNPSSAAVLPAARQPNETLFPMEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX9</accession>
    <name>A0A1E7MYX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1097"/>
    <dbReference type="EnsemblBacteria" id="ARF78982">
        <property type="protein sequence ID" value="ARF78982"/>
        <property type="gene ID" value="B6264_08680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33638">
        <property type="protein sequence ID" value="OEV33638"/>
        <property type="gene ID" value="HS99_0038545"/>
    </dbReference>
    <dbReference type="OMA" id="EYHANGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15609" checksum="4B8A64593EDECCB2" modified="2017-01-18" version="1">MSDTIGSPRSGNALNVPGLAGRAHTPVETVREAYSFACLRCGYGWEQAYDIEHHVARDGHIVFEYHANGVRVPSPLLKPTCPGCGGHTVRIMREGRVASADQPWQHAPGYPAHAEPAGATPVPAVPEPVKPRGRWARFWARLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYY9</accession>
    <name>A0A1E7MYY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78974">
        <property type="protein sequence ID" value="ARF78974"/>
        <property type="gene ID" value="B6264_08640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33646">
        <property type="protein sequence ID" value="OEV33646"/>
        <property type="gene ID" value="HS99_0038585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="7279" checksum="9735BAF87E3747FA" modified="2017-01-18" version="1">MRFEGVAQLFQNATSLPKLITTAQHHGGVGVLHHVNELLVLEIIELGFACHYLLPVSPYVFPRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ47</accession>
    <name>A0A1E7MZ47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597621.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1939"/>
    <dbReference type="EnsemblBacteria" id="ARF79609">
        <property type="protein sequence ID" value="ARF79609"/>
        <property type="gene ID" value="B6264_12405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33708">
        <property type="protein sequence ID" value="OEV33708"/>
        <property type="gene ID" value="HS99_0038150"/>
    </dbReference>
    <dbReference type="OMA" id="GTVACCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041356">
        <property type="entry name" value="PGM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040754">
        <property type="entry name" value="PreAtp-grasp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18105">
        <property type="entry name" value="PGM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18604">
        <property type="entry name" value="PreAtp-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="48313" checksum="BAD75494B1ED77FF" modified="2017-01-18" version="1">MPKLIVSNQRTDEMIGDLGSLTPEYRRYVAGQAQRMVWLAEAGDVLVLPVQLDEQFLSYVAALKGIDRGSWAVVVPPVGSLGEDVLSRDRLEDPEFVTRLKAAVRDHEVRTILPFHFDRVSVRLARTLGLDRHTPGFPFAAQSGTALLNSKAAFRALAVGHGIPVPFGTVTDDRQEAEEFLWEAIGAGQPVIVKQDFHVGGIGNEIISPVPGIRPIGATGTELITDRAALAAHLDRRWAHYAGPHRGRVVLEHYTPESPAIYSELLVTDEGVRLVGHGEMRMKPVINGLIVPAPSVRLPAFAGFLDDSRQLSETLHRMGYRGSLSVDAIVTPDDTILVNEINGRVVGSAHIHRIGEELVGGDYTRERVLIEKRRVAFPDFRTTLDKLTATSLAFDPARRTGVVVTVHDNGRTGGFGGCCLIAEDDAAARVLEEEVDALFGTAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ48</accession>
    <name>A0A1E7MZ48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366694.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1927"/>
    <dbReference type="EnsemblBacteria" id="OEV33712">
        <property type="protein sequence ID" value="OEV33712"/>
        <property type="gene ID" value="HS99_0038200"/>
    </dbReference>
    <dbReference type="OMA" id="IVWRVPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="62"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="234"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="48813" checksum="ADC8AB8FE072DE20" modified="2017-01-18" version="1">MGTPANGPPGDPPGFVHIPDPARLELDRAVQAVVTRANDVLHAESRLRDLLRAVLAVTTDIASPGVLDHLVNAARELLGARFAALAVLDDEGRLVQFRHSGIEPSAAREIGPWPRGEGVLGRLRTQSGPLRIDDINAAPDTYGFPTGHPTMRSFLGVPIRARGRTFGALYLADKQGAGTVPAPFTTEDEELLQALAGAASAAVDNARLYEQAQRREAWQHATALISSALLARTEPDQVLALIVEQARQVAGADIAAIALPETPERLVIRIAAGQYADRVTGQYLPTAQSLTGLVLTRGEPLITADLATDGRSHQPDTDLSPASGPAMFAPLTARGSRTGVLFVTRQPGRAGFDHDQLDMLTVFAAQAALAERLAAERADAELVTQVRDHERIAQDLRDRVIEGIFAISLTLNGLATTAPPHRQQHLLDTVGRLDTVIRDIRATVFDLRHPDPGPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ61</accession>
    <name>A0A1E7MZ61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278569.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000222.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79619">
        <property type="protein sequence ID" value="ARF79619"/>
        <property type="gene ID" value="B6264_12490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33716">
        <property type="protein sequence ID" value="OEV33716"/>
        <property type="gene ID" value="HS99_0038225"/>
    </dbReference>
    <dbReference type="OMA" id="IFEYDLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8929" checksum="2BD321D4D8FE0A3A" modified="2017-01-18" version="1">MSVYVKLSPEARAPAEPSKGPLDLQYEDGADGVIFEYDLHPSGALRVLRVFEDTPHRIEACFSPGAWLQVAGTYLRSGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG3</accession>
    <name>A0A1E7MZG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348197.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5238"/>
    <dbReference type="EnsemblBacteria" id="ARF82914">
        <property type="protein sequence ID" value="ARF82914"/>
        <property type="gene ID" value="B6264_18665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33613">
        <property type="protein sequence ID" value="OEV33613"/>
        <property type="gene ID" value="HS99_0013445"/>
    </dbReference>
    <dbReference type="OMA" id="FIMIMPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="35740" checksum="DD25665483B78B28" modified="2017-01-18" version="1">MTGAAVLTLAASLAACGGSDDGKGKSSSADGTPAATAGTGTPAATGSAAPGTPTAEQPTPANGKVLMPTGPAANLSKVRDTAAGPIMMTKVTGAKSGVTGQVWVWLPPEYNDPKFAKTGFPVLTLYAGGQSNGYNTWTDNQLPIQEVDEQLVKQGKAHPFIMIMPVQNFNSDEKNALDCSDIPGQPKMGTWMAEDIPAWVRANFRTLQGRDSWGVMGASTGGFCSAKLALQYPNVYKAAVPIDGYFIPDSGLWKGHDAEKAANNPNLLVTQGKADVKMYVTAGGANGYEKEVVKSWVAKAVAPVSIQYYEQPGGKHLTSDFKKMIPDTLQWLSANLAGPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZG7</accession>
    <name>A0A1E7MZG7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000377.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4531"/>
    <dbReference type="EnsemblBacteria" id="ARF80388">
        <property type="protein sequence ID" value="ARF80388"/>
        <property type="gene ID" value="B6264_17050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33809">
        <property type="protein sequence ID" value="OEV33809"/>
        <property type="gene ID" value="HS99_0037675"/>
    </dbReference>
    <dbReference type="OMA" id="KTPVDFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="23066" checksum="F7B30E367C8A70B8" modified="2017-01-18" version="1">MTTAAERKTADFWFDPACPWAWMTSRWLIEVQQLRPVDVNWHVMSLSVLNEHRDLPQNYRELLDNAWGAVRVCIAAAQQHGEEVLGRLYTELGLRFHNQGLPQNRETVEAALVAAGLPVELADAADTDAYDEALRASHKEGITLVGEDVGTPVIAVEGADGERVAFFGPVVTPAPKGEAAARLWDGTLLVASTPGFYEIKRTRTAGPSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N025</accession>
    <name>A0A1E7N025_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ureF</name>
        <name evidence="2" type="ORF">HS99_0011275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551777.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2266"/>
    <dbReference type="EnsemblBacteria" id="ARF77877">
        <property type="protein sequence ID" value="ARF77877"/>
        <property type="gene ID" value="B6264_02125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34021">
        <property type="protein sequence ID" value="OEV34021"/>
        <property type="gene ID" value="HS99_0011275"/>
    </dbReference>
    <dbReference type="OMA" id="TQYTRLF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="24632" checksum="77072861FEF7B473" modified="2017-01-18" version="1">MSSPTGDGLDALLVSLQLTDSAFPSGFYTLSHGLEGYAQAKAVTPDTVPELLADLLRHSVGPSDATALALAHRAASEGDWELLVEIDQRLHATKLNRELRLAAARTGRQLLDIARESVGGEPLERYAELVADKRAPGCQAVAAGVAYASAAVPVEQAVASDLFAFCTSFVGAALRLRLTDHRRAQVVLRAAAPVIREVVAAALVRESADLGGCVPIADAMSGRHERAEARLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N026</accession>
    <name>A0A1E7N026_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77904">
        <property type="protein sequence ID" value="ARF77904"/>
        <property type="gene ID" value="B6264_02285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34047">
        <property type="protein sequence ID" value="OEV34047"/>
        <property type="gene ID" value="HS99_0011435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="22269" checksum="438749F3F5491298" modified="2017-01-18" version="1">MQEEWEVGLSDFPLLSFSRAAVSPRSRFLEMADDLLNAGGLLRLIADDVMKAKVRMSERHPAFSKAFTSEEAKALEVHEYSMFAIPGLLQTASHARALYEVRRPWLSTEQIDKWVAARLGRQEILAKWPMSSISWVVDESVLRRPLGGWDTHQEQLRHLLKVAEIRGLELQIMPLAKEQNAGMGGPFTLLTPPGRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N060</accession>
    <name>A0A1E7N060_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551847.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2319"/>
    <dbReference type="EnsemblBacteria" id="ARF77924">
        <property type="protein sequence ID" value="ARF77924"/>
        <property type="gene ID" value="B6264_02395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34066">
        <property type="protein sequence ID" value="OEV34066"/>
        <property type="gene ID" value="HS99_0011545"/>
    </dbReference>
    <dbReference type="OMA" id="PRCHDEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="53972" checksum="243F24FFDC56E676" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N074</accession>
    <name>A0A1E7N074_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000766.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2330"/>
    <dbReference type="EnsemblBacteria" id="ARF77935">
        <property type="protein sequence ID" value="ARF77935"/>
        <property type="gene ID" value="B6264_02450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34076">
        <property type="protein sequence ID" value="OEV34076"/>
        <property type="gene ID" value="HS99_0011595"/>
    </dbReference>
    <dbReference type="OMA" id="LSCGGCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="30430" checksum="13F43A21FF3107B6" modified="2017-01-18" version="1">MASEVNLAQLRALVAVADTGGFGAAADELGISQSAVSHAVAALERSLGAPVLRRGTPCRPTPLGEQVLPHARTAVASAAAVRTIATRHSGGPTGTVRLAAPTTVCQALLPGLLRDWKAAYPQVTVRVFEGEDAELATWLEAGTVDAAVLVDADRPPPGAVALGADSMHALLRRDHPLAGQETVHVGELEDDDFLLSEGGCERHIREAYRRAGARFAPRHRIRDLNTLIGMVHAGVGVSVMPALALTMLPPDCVLVPIRPAVHRTLTLTGPSHRPWSPAVTGLLAGVGTTVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N094</accession>
    <name>A0A1E7N094_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2357"/>
    <dbReference type="EnsemblBacteria" id="OEV34096">
        <property type="protein sequence ID" value="OEV34096"/>
        <property type="gene ID" value="HS99_0011720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="10006" checksum="1E0B8F418C7D0E29" modified="2017-01-18" version="1">MVYGNASQQDHVYEANQMWYTAKTVAGYNIGGLAGQQPDLVHGHLVEAARRLATGAVRIETTQLALEDAVKAHEILERRDSTGKFVLRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0B5</accession>
    <name>A0A1E7N0B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387088.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000661.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1847"/>
    <dbReference type="EnsemblBacteria" id="ARF77756">
        <property type="protein sequence ID" value="ARF77756"/>
        <property type="gene ID" value="B6264_01385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33913">
        <property type="protein sequence ID" value="OEV33913"/>
        <property type="gene ID" value="HS99_0010545"/>
    </dbReference>
    <dbReference type="OMA" id="DLLSNTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14668" checksum="EE89B7DA825C5441" modified="2017-01-18" version="1">MGTEDVIENRADHDLGGGLFAADCRARLAFEVIANRWDSVVVYVLGECGPMRPRSLLDRIGGLSPKVLNESLRRLEYNGLVERRRYAEAPPRVDYTLTEAGTALLDPIRALGAWAAVHGDAVLASQELHGDKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N8</accession>
    <name>A0A1E7N0N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase C69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6062"/>
    <dbReference type="EnsemblBacteria" id="OEV34260">
        <property type="protein sequence ID" value="OEV34260"/>
        <property type="gene ID" value="HS99_0036895"/>
    </dbReference>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="263"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="517" mass="55419" checksum="A4393F4312918540" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P8</accession>
    <name>A0A1E7N0P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283661.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2596"/>
    <dbReference type="EnsemblBacteria" id="OEV34270">
        <property type="protein sequence ID" value="OEV34270"/>
        <property type="gene ID" value="HS99_0036710"/>
    </dbReference>
    <dbReference type="OMA" id="HGQTQWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32577" checksum="6694C20EE11F3C6D" modified="2017-01-18" version="1">MDTPAVRISGAVKTFGTTTAVGGLDLEVPAGMFLGLLGPNGAGKSTTMRMLTGQTRADSGTVEVFGHRMPDDSRRARSLVGVVPQHDNIDPELTVRQNLDVFVRFTALPRAGYRDAVDRALAAVRLTDRADTRADALSGGMRRRVLLARGIVNNPRLLLMDEPTVGLDPQIRQDLWDVIDGMRESGTTVVMSTHYIEEAERLADEVAVVFGGRLIARGTPAELLHAHAGAQAAEYRGDAARRELVEAEAARAGLPSRRTGPAVSVLRAETVPARMHERLGSPDVLRPTSLEDVFVALTGELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S3</accession>
    <name>A0A1E7N0S3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290921.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1894"/>
    <dbReference type="EnsemblBacteria" id="ARF78502">
        <property type="protein sequence ID" value="ARF78502"/>
        <property type="gene ID" value="B6264_05855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34289">
        <property type="protein sequence ID" value="OEV34289"/>
        <property type="gene ID" value="HS99_0036525"/>
    </dbReference>
    <dbReference type="OMA" id="QYEGIPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="566"/>
            <end position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="898" mass="94829" checksum="C6FA3C516A37D154" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N122</accession>
    <name>A0A1E7N122_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3922"/>
    <dbReference type="EnsemblBacteria" id="OEV34389">
        <property type="protein sequence ID" value="OEV34389"/>
        <property type="gene ID" value="HS99_0036220"/>
    </dbReference>
    <dbReference type="OMA" id="FNGLYEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="41383" checksum="92A9ABAB6E80B7A7" modified="2017-01-18" version="1">MRAALAAATEDTVIYDLDGIGRQYAALRAELPDVAVRFAMKACPVDEVLDHLAGLGSGFDAASPQEIAQALRTGVAPELIHYGNTVKSDRNIAEAYRMGVRDFATDSLEDVAAITEHAPGSRVFCRVATTGEGALWGLSHKFGCSPEDALRVLGAARTAGLVPSGLSVHVGSQQMTAEAWTAAIDSLAAVLETLNWRGITPTRVNLGGGLPALGVLDRGGRPLEPPLDKMFTVIREGMERLRAVNAAPLEFLLEPGRHLVADHGAIRAHVARLTSRHQLDGTRADWLYLSCGKFNGLYEMDQLQYRLEFPTHPGGQFVNAVVAGPTCDSDDAYAQEDGPVRVPHAIASGDPVWIHSCGAYATAYATRGFNGFPPLPYTCIGGSGDRGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1K0</accession>
    <name>A0A1E7N1K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552794.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79361">
        <property type="protein sequence ID" value="ARF79361"/>
        <property type="gene ID" value="B6264_10890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34569">
        <property type="protein sequence ID" value="OEV34569"/>
        <property type="gene ID" value="HS99_0035360"/>
    </dbReference>
    <dbReference type="OMA" id="KKYTCPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="22351" checksum="4730403177DCF02A" modified="2017-01-18" version="1">MRPARLPAACALLVLTIGPVALATAPALAADATPTPSSSATGDCPEGTTADPIPVTSSSDAAGELAVTFTNPGTATAKQLATTVALADGGSLPVELRAGSGAWKSLTVAGSPLNTGSYQLPQGQRLTLRVRLAAGAAQGDHRLTFTARSEVLPSGSAPAKKYTCPQLTASYTAPLTPANHTPDPTHLADTGAGTATRPLAIAGTTALLLGTALLVLTRRRPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q1</accession>
    <name>A0A1E7N1Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554764.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000116.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4284"/>
    <dbReference type="EnsemblBacteria" id="ARF82023">
        <property type="protein sequence ID" value="ARF82023"/>
        <property type="gene ID" value="B6264_26865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34611">
        <property type="protein sequence ID" value="OEV34611"/>
        <property type="gene ID" value="HS99_0008925"/>
    </dbReference>
    <dbReference type="OMA" id="RDAQMIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="42161" checksum="39FF3B4AFEA1DEBE" modified="2017-01-18" version="1">MVHQHKIALAGSAHLELVSGVVQLRPEDAMFDAMLRGWRAQQKARGLQDETVEDRERLIRRFHEFANDYPWQWTPAHMDEWSVCLTGEKHLAPFTIRGYQGIVRLFSEFVIDSRYGWVPACEEAFGAFPVAICHEWNTIPHLQDYEGSPEARPFTRDELQRFLDYADDQVDRAVRAKRKGALAAYRDATLFKVIYGWGLRRTETSKLDVVDFGRNPQAPQFGRYGTLNVRYGKAKKGQQPRRRNVLSVMDWAVEAVADYVENVRPRFGFPDHPALWITERGGRLQPGSINDRFEAYRNALKLPKDLVPHSIRHSYVTYLTEDGVDRRFIQQQVGHECDSSTTIYTHVSDDFVNTALHKALAPAFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N258</accession>
    <name>A0A1E7N258_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366236.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4599"/>
    <dbReference type="EnsemblBacteria" id="OEV34756">
        <property type="protein sequence ID" value="OEV34756"/>
        <property type="gene ID" value="HS99_0009755"/>
    </dbReference>
    <dbReference type="OMA" id="VERYHHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="49"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="32117" checksum="06D38247AF001A2D" modified="2017-01-18" version="1">MPDELTGAAAPVIRLRPDFRPTAFLSRTDKSLLIAGDCEDGPAVAKLLTTREPLWVEKFSAEIEAYRAFAETPPPVPVPGLIAVDDRHHVLVIEHVPGHLPAPGRDRCPPQALDPAHVTAMLTAMSDLSRWSPPTGAFTRTLDYLARLDRDHRQGLTTPQEHQALTDLFHRAGTDLVPGHGDPLPTNFVVRPDGRVTVIDWEHAGHYLPGHDLAVLWIVLAATPKARPQIEELVAAGPQSVRAAFTLNRAMLLVRELRNHRAVPPSTWRDQRMAVIERDWHDVRALAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N298</accession>
    <name>A0A1E7N298_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556966.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3215"/>
    <dbReference type="EnsemblBacteria" id="ARF81826">
        <property type="protein sequence ID" value="ARF81826"/>
        <property type="gene ID" value="B6264_25645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34814">
        <property type="protein sequence ID" value="OEV34814"/>
        <property type="gene ID" value="HS99_0010100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="49000" checksum="665EE214205409CF" modified="2017-01-18" version="1">MNGLRVELKRSLAPWPGLVVLGGSLAVFCLIDGIWWQGDAGWTAQWTSMALWTRSLLAFWWPLVVGTGAVYGLRDSRSRMTELLTTTPLPPWRRAALPAGATAIVLASGFGLLVLVGAVQVALGATTYTSLGWLPVSLVAALSLVAGAVFGMGVARAVPSVLTPPALTVFLLLATLLLRPSNEGLLPSSSAPNRLALLSPATSEPREVLLTLSGSVHLGQTLWLLGLLATGFALLSAATRRARLLAVAPVLVGAALALVILPATARDTYVVDKAAATSVCDGPVCVTQANRSHLPELAPRGRDALRVLHDALGDQAPTSVREDTRLHALGDDRQPSGDAVLVDFDDPLIARATGAELTRLLVAQGLAPNCAPRTTWEGRGQLDIPVQSIVASWALGDRRFEALQRPDTYAYSPRTWADADAAWKRLTAMSPADQRSRIAEVHTAALSCTGYHELSMLAGETPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2A8</accession>
    <name>A0A1E7N2A8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366283.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3205"/>
    <dbReference type="EnsemblBacteria" id="OEV34824">
        <property type="protein sequence ID" value="OEV34824"/>
        <property type="gene ID" value="HS99_0010155"/>
    </dbReference>
    <dbReference type="OMA" id="WLVEMEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="22471" checksum="423625587EB8F822" modified="2017-01-18" version="1">MMMNSRALMGAGAAAAVATWWFTDSAPYPYSQRWLLDLPLPFLTLKRLDHVLQAREGERILEIGPGTGLQSLHVAPQLGPNGQLDIVDIQQEMLDHVGRRAKEQGVDNIVPSCADAHELLFADNSFDAAYLVTALGEIPDPARTLAELRRVLKPFGRLVVGEFFDRHQIRPSSLISLAEGAGLRVARLYGPPFAYYAVLRPIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F9</accession>
    <name>A0A1E7N2F9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557735.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000168.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7603"/>
    <dbReference type="EnsemblBacteria" id="ARF81783">
        <property type="protein sequence ID" value="ARF81783"/>
        <property type="gene ID" value="B6264_25380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34855">
        <property type="protein sequence ID" value="OEV34855"/>
        <property type="gene ID" value="HS99_0010340"/>
    </dbReference>
    <dbReference type="OMA" id="MLPGKFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="15492" checksum="6F21303FB066567A" modified="2017-01-18" version="1">MSTDILQKSAPASTITRAAAGALIAAVHTAAARIGFTAAVAVTDPGGHLKAFDRADDALFLTAEVALDKAWTAASFQTPTHTWNDHLANPRLSPLAAHPRLMAVGGGYPIVENGRCLGGLGISGGSYEQDQQAAEEALTALGFELQTAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J3</accession>
    <name>A0A1E7N2J3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554087.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5858"/>
    <dbReference type="EnsemblBacteria" id="OEV34907">
        <property type="protein sequence ID" value="OEV34907"/>
        <property type="gene ID" value="HS99_0034910"/>
    </dbReference>
    <dbReference type="OMA" id="YWHTCLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="253"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="36025" checksum="80239A04DAC6960C" modified="2017-01-18" version="1">MHRFTLRLADLASTWFAYSPILEATLSLRMWSHPGVYRLQSRAFEQLRPSFERLDSRLLLSLVADNRWVPDFLTPRPSAPAPEFRTELATVRGLPPELLRSELEQTFRPNGQPLPALLEAGLADPERLLARICDALEEYWEACLAPTWWPQARAVLEADLVYRARVLAQHGAAALFTDLDHRLQWTDGVLSINRHWTDGDVETAVDGRGLVLCPTFFVRGAITMIDSSRAPQISYPARGQAGMAGQGSPVPPQALEALVGAPKARLLSLLAEPASTTELAYRLGVTPGAVSQHLSVLAATGLVTRARHGRSVLYRRSVLGDELTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L7</accession>
    <name>A0A1E7N2L7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555951.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4659"/>
    <dbReference type="EnsemblBacteria" id="ARF81933">
        <property type="protein sequence ID" value="ARF81933"/>
        <property type="gene ID" value="B6264_26335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34703">
        <property type="protein sequence ID" value="OEV34703"/>
        <property type="gene ID" value="HS99_0009445"/>
    </dbReference>
    <dbReference type="OMA" id="MFVEIDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="10403" checksum="BCE2784E4A4C359B" modified="2017-01-18" version="1">MFVEIDAEAFAERTRLELAEFAVAMSPAAMHRTVELTERESRIARRARDGRSNAEIGAELLLSAPPVEWHLRKVFTKLRISSRQELRTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U2</accession>
    <name>A0A1E7N2U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81864">
        <property type="protein sequence ID" value="ARF81864"/>
        <property type="gene ID" value="B6264_25905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34773">
        <property type="protein sequence ID" value="OEV34773"/>
        <property type="gene ID" value="HS99_0009850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="10976" checksum="44D0AABB8BB867A8" modified="2017-01-18" version="1">MFMTATPRLWAGKETDRLRVAMAGIEAAELIASMDDEALFGPVTHDYPLGTAISDGVIGSASALNRTVTPCSAKDSITRVTSTTGPPPLGIEQAEGYTGRYEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y4</accession>
    <name>A0A1E7N2Y4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0034495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552895.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000746.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4724"/>
    <dbReference type="EnsemblBacteria" id="OEV35044">
        <property type="protein sequence ID" value="OEV35044"/>
        <property type="gene ID" value="HS99_0034495"/>
    </dbReference>
    <dbReference type="OMA" id="DRPIFAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="3">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="41231" checksum="63AD5C074345EC0D" modified="2017-01-18" version="1">MNHARDLRIAIVGAGLGGLTCARVLQRHGRRVTVFEREAGPDARPQGGTLDLHADTGQAALCAAGLLERFQALARPEGDQWRVLDPATAEPLAQQGPPAGPDRGLEPDPNPGPGPDADSDSGARPEIDRGQLRGLLLDSLTAGTVHWGRAVSAATPLTDGTCRLHFADGTTEDFDLVVGADGAWSRVRPALSPAVPGYTGVTFLETGFDHCDTRHPDLARLVGHGSMLAKGAGRTLVAQRNSNHHIRAYIALRTPQDWHTAAGVDPGDQQAVRAHLLDLFEGWHVSLRRLLHGGDHPFTSRPLFVLPAPHTWRHVPGLTLLGDAAHLMPPVGLGANLAMLDGADLAHALASAADVDTAVRAYEDLMLPRSTRAATDSAHALDHLVPATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z0</accession>
    <name>A0A1E7N2Z0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386909.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4686"/>
    <dbReference type="EnsemblBacteria" id="OEV35061">
        <property type="protein sequence ID" value="OEV35061"/>
        <property type="gene ID" value="HS99_0034305"/>
    </dbReference>
    <dbReference type="OMA" id="FRRYWTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16361" checksum="3FD4225BC6F5ADED" modified="2017-01-18" version="1">MLDTDGDGVASRHDYFVRIERARQATGRSHDDPLVVAALTAGERAWAAMDANGDGVMTYEEYAAWVDADKFDNVCRYALGALFDLADADQDGALDRSQFTALRQALGNRAGNADAAFDALDGDGDGRVGRVEYLASIRAFVTGDGSPMGEALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Z1</accession>
    <name>A0A1E7N2Z1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284811.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000338.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4714"/>
    <dbReference type="EnsemblBacteria" id="OEV35035">
        <property type="protein sequence ID" value="OEV35035"/>
        <property type="gene ID" value="HS99_0034445"/>
    </dbReference>
    <dbReference type="OMA" id="MEPHMAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10944" checksum="FECF9BB570599241" modified="2017-01-18" version="1">MFILELTYTAALERIDEALPQHVQWLNGHYAAGTFLASGRKVPRDGGVILAVGQDRARIEELVATDPFVRLGLTEYRVTEFLATVTAPALEAHRQQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4B9</accession>
    <name>A0A1E7N4B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2152"/>
    <dbReference type="EnsemblBacteria" id="ARF79426">
        <property type="protein sequence ID" value="ARF79426"/>
        <property type="gene ID" value="B6264_11285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35537">
        <property type="protein sequence ID" value="OEV35537"/>
        <property type="gene ID" value="HS99_0032095"/>
    </dbReference>
    <dbReference type="OMA" id="GSRWQDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011020">
        <property type="entry name" value="HTTM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00752">
        <property type="entry name" value="HTTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="44541" checksum="00EBB6EC3E9740F9" modified="2017-01-18" version="1">MNEASAVEPVEVPGFPRQLPGPPVVPPVPVAPRGPVAALGRAMGTFTGRALGRHQAAVVRIGFGLVWLAYLLREWPNRRVLYGDRSPWSMELAQRLLADDGAFTVLPWFGGRLWFELVYHLAVLAALAVLLGWRTRASTVLFLVTVLSLQNRDVLLGDGGDNVVHLMAVYLVFTRCAEVWSLDARRVGPGRSGVVLWALLGAALAICQAGDFSGDSLTWTAPTFPHIGWAPLFWGLWAVAGFWWLLGRLRPAGEPRAVLDALANMVHNCAMLVIATEVVLVYATAGWYKVQGSRWQDGTALYYPLHLDYFTPWPALSGLVGSALLPVFLISYATVALQVAFPFTLMNRRVKNVLLAVMMAEHLGIAVVLGLPVFSLAMVAADAVFLPTGALLWAAQRLGRLRRRLVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D4</accession>
    <name>A0A1E7N4D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278202.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5492"/>
    <dbReference type="EnsemblBacteria" id="ARF79412">
        <property type="protein sequence ID" value="ARF79412"/>
        <property type="gene ID" value="B6264_11200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35524">
        <property type="protein sequence ID" value="OEV35524"/>
        <property type="gene ID" value="HS99_0032010"/>
    </dbReference>
    <dbReference type="OMA" id="GVKVQHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20602" checksum="8D866E96FF849405" modified="2017-01-18" version="1">MGPDNRTPPPRPVVKRTARAILLELDPDDPYGPASIVLIRRVRPGAPHPYWITPGGGVERDDRTVVEALHREVDEELGGKIVDVVPAFVDTISHPLPQPPAGGTPIDDGTLLHPHGVKVQHFFVCRLASMDLSRRHGPEVTDPNGEYQVVRLPFTREGVTSVNVVPPRLRAYLAANIEGIRALLAPDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4G4</accession>
    <name>A0A1E7N4G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000790.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5367"/>
    <dbReference type="EnsemblBacteria" id="ARF80769">
        <property type="protein sequence ID" value="ARF80769"/>
        <property type="gene ID" value="B6264_19310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35575">
        <property type="protein sequence ID" value="OEV35575"/>
        <property type="gene ID" value="HS99_0006545"/>
    </dbReference>
    <dbReference type="OMA" id="IMLFHST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20763" checksum="029816A497C9BD24" modified="2017-01-18" version="1">MAQIVLFHSSHGLNPAVRGAADRLRAAGHTVHTPDLFEGRTFDDSEASRTYQEEVGGGDELLRRAVTASAPLSEGGLVYAGIGLGGAIAQNLALADEKARGLLLLHGTSDLREDAVTGVPVQLHMAEPDPHEPEDWLNAWYLRMRRAGAEVEVHRYQGAGHLFTDPDLDDYDAEAAERAWAAALDFLADLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R7</accession>
    <name>A0A1E7N4R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0007135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551137.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene899"/>
    <dbReference type="EnsemblBacteria" id="ARF80872">
        <property type="protein sequence ID" value="ARF80872"/>
        <property type="gene ID" value="B6264_19905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35675">
        <property type="protein sequence ID" value="OEV35675"/>
        <property type="gene ID" value="HS99_0007135"/>
    </dbReference>
    <dbReference type="OMA" id="DYNILMI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="736" mass="77525" checksum="B241BAA975667D8F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V5</accession>
    <name>A0A1E7N4V5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0007490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281577.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene830"/>
    <dbReference type="EnsemblBacteria" id="ARF80931">
        <property type="protein sequence ID" value="ARF80931"/>
        <property type="gene ID" value="B6264_20260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35728">
        <property type="protein sequence ID" value="OEV35728"/>
        <property type="gene ID" value="HS99_0007490"/>
    </dbReference>
    <dbReference type="OMA" id="SAAIWKF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="PTHR31611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00802">
        <property type="entry name" value="nico"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="40876" checksum="F5BCBFA06BADF36F" modified="2017-01-18" version="1">MPSTAPGAPAGAAPVRWRDRLTREEWIRLAGMGGFILALHVIGWFTLLALVAPEHYDVGGQVFGAGMGLTAYTLGMRHAFDADHIAAIDNTTRKLMGQGKRPLSVGFWFSLGHSSIVFGLCALLAFGIRTLADQVEADDSTLHRMTGLIGTTVSGSFLLLLGLINLGAFNGILRVFRRMRLGEYDEAELERQLERRGLMNRILGKVTRAVSKSWHMYPVGLLFGLGFDTATEVSLLVLAGGAAAFSLPWYALLTLPILFAAGMSLLDTIDGSFMNFAYEWAFSKPVRKIYYNLTVTGLSVLVALVIGLVELIGLLGEKLDITSGPIAWIGDLDLNFVGYAIVGLFVLTWIGAIAFWKFGKVEEKWSAGLAAASAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N546</accession>
    <name>A0A1E7N546_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80985">
        <property type="protein sequence ID" value="ARF80985"/>
        <property type="gene ID" value="B6264_20600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35774">
        <property type="protein sequence ID" value="OEV35774"/>
        <property type="gene ID" value="HS99_0007825"/>
    </dbReference>
    <dbReference type="OMA" id="DAWCRFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12211" checksum="1DEB56BFC3545175" modified="2017-01-18" version="1">MLLGISAALSLASAGALYALLYVRSLDYGDRCERGLVSGGGRLLETGASWLPPDAWCRFEHRSLSTTPFWALLLFYVLLTVVVSAVTSLVRTLRPRPNPGLDWQPGHGAGPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N557</accession>
    <name>A0A1E7N557_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286058.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000818.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81032">
        <property type="protein sequence ID" value="ARF81032"/>
        <property type="gene ID" value="B6264_20880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35822">
        <property type="protein sequence ID" value="OEV35822"/>
        <property type="gene ID" value="HS99_0008105"/>
    </dbReference>
    <dbReference type="OMA" id="RYRRCEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="12225" checksum="B262512E22E55367" modified="2017-01-18" version="1">MTAQAAVDRIGDHPDAADITLQRILEAFADPVRRSIVRQIARAAGDTACGTFDISVTRSTGTHHFRVLRQSGLIRQYYVGTSKMNTLRRDDLEQAFPGLLDALIAAADREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B6</accession>
    <name>A0A1E7N5B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553583.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7245"/>
    <dbReference type="EnsemblBacteria" id="ARF81080">
        <property type="protein sequence ID" value="ARF81080"/>
        <property type="gene ID" value="B6264_21155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35868">
        <property type="protein sequence ID" value="OEV35868"/>
        <property type="gene ID" value="HS99_0008380"/>
    </dbReference>
    <dbReference type="OMA" id="AVKAFTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="30409" checksum="44A6442B32291F0C" modified="2017-01-18" version="1">MPGTGGLGPAGAVRAIERVLLDGLDPEAAPARSAVPVPAGELLLMPAAAGPYAGVKIAGVVPDNPARGLPRITGSYLLLDGATLQPLAVLDGAALTALRTPAVTAAALARLAEPEAEHLVVFGSGPQAYGHLDALLAVRPLRRLTVVARDPGRVAALVAYGRGLGLMASAGGPEAVGRADVVVCCTTARTPLFDGALVPAHAAVAAVGSHEPEAREVDEVLVGRAELYVEARTVAAREAGDLLLAGVGGRQLWNLAELVRGDALVPDGRPRFFKSVGMAWEDLAVAAEVYRAGRRRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N641</accession>
    <name>A0A1E7N641_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284378.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000192.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8120"/>
    <dbReference type="EnsemblBacteria" id="ARF79775">
        <property type="protein sequence ID" value="ARF79775"/>
        <property type="gene ID" value="B6264_13450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36167">
        <property type="protein sequence ID" value="OEV36167"/>
        <property type="gene ID" value="HS99_0030405"/>
    </dbReference>
    <dbReference type="OMA" id="AWATSDN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="17168" checksum="7BC52900FF3C54E6" modified="2017-01-18" version="1">MVRQLGELENAIMTRVWRWNRPVTVREVLLDLQSEREIAYTTVMTVLDKLHRKGWLRRERAGRAYRYEPVSSREAYTAALMNDAWATSDNPAAALVHFFGLMSPEQREALRDALRVAALFPSDPPGPESAEDGPDTGGPDTGGADTGETAPGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N653</accession>
    <name>A0A1E7N653_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0030430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829609.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8114"/>
    <dbReference type="EnsemblBacteria" id="ARF79780">
        <property type="protein sequence ID" value="ARF79780"/>
        <property type="gene ID" value="B6264_13475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36171">
        <property type="protein sequence ID" value="OEV36171"/>
        <property type="gene ID" value="HS99_0030430"/>
    </dbReference>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="13">
        <location>
            <begin position="446"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV36171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="557" mass="58180" checksum="173BA2A8B8DCC230" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C2</accession>
    <name>A0A1E7N6C2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8031"/>
    <dbReference type="EnsemblBacteria" id="OEV36256">
        <property type="protein sequence ID" value="OEV36256"/>
        <property type="gene ID" value="HS99_0030845"/>
    </dbReference>
    <dbReference type="OMA" id="LTYPLWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="183"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="41682" checksum="38C56EDA2980D2EF" modified="2017-01-18" version="1">MERPPLYGARMWRQVGHLMLNLPLGIAGFVLSVTALSVGLGLSVTVIGLPVLAAGLAGSRALGAQGRNRARSVYGSRIDEPEPVRPRRPGMVAYTIAHLTDLLNWRSALYNVLMLPWGILSFALSLVSVIVLWPVLPVVVRTMAAVDRILIESLLFPGALAERVRELEDDRGTVVDTAAADLRRIERDLHDGAQARLVALAMDLGMAKERLREVETQEDVAVATRMVDNAHGEVKLALQELRDLARGIHPAVLTDRGLDAALSAVAARCTVPGGVKVNVDLAGPDGEPERPDSAVEGIAYFTVSELLTNVSKHAGARTASVDVWRSDNQLMVLVHDDGKGGAAPYPGSGLGGLAERIRAVDGVFLVNSPEGGPTTVTVELPWRTRTTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C7</accession>
    <name>A0A1E7N6C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284229.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8045"/>
    <dbReference type="EnsemblBacteria" id="ARF79840">
        <property type="protein sequence ID" value="ARF79840"/>
        <property type="gene ID" value="B6264_13830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36228">
        <property type="protein sequence ID" value="OEV36228"/>
        <property type="gene ID" value="HS99_0030775"/>
    </dbReference>
    <dbReference type="OMA" id="DHRPPRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13126" checksum="57C390880C80CAC7" modified="2017-01-18" version="1">MIGTLQCLVLDCPDPGALARFYAAVLGGEVDRPDRRWSLGAGWSTLHLDDGTVFCFQGVADHRPPRWPDGEHPQQAHLDIDVADLDTAEAAVLALGAVRLHDAGGWRVHADPAGHPFCLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A3</accession>
    <name>A0A1E7N7A3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36570">
        <property type="protein sequence ID" value="OEV36570"/>
        <property type="gene ID" value="HS99_0029055"/>
    </dbReference>
    <dbReference type="OMA" id="QFIHRIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="31849" checksum="1B4D7A19CE4032C2" modified="2017-01-18" version="1">MPPRLNPTLRQRRIGTELRKMREAAGLSTGALSRDLGIDRTQVSQIEAAKVGVSPERLRSFAAACKCMNEPLIGALESMVQDRSKGWWEDHRGTVPDGFLENAELEKTSRELMLWVLTHMPGPCQTINYASAVFGRVFPPLPRHAIEARTAFRMQRKTDLRRNPKPLTAFIYESVLWTRFGGTPILKEQLGSLLEDSELPWMSIRVVPFDIETFPGAVENLTYAFGIIPELDTVERESSRDSEHLDATSELASYRAIFEQTEALALNESDSRDLIHKIARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C4</accession>
    <name>A0A1E7N7C4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289686.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79128">
        <property type="protein sequence ID" value="ARF79128"/>
        <property type="gene ID" value="B6264_09535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36569">
        <property type="protein sequence ID" value="OEV36569"/>
        <property type="gene ID" value="HS99_0029050"/>
    </dbReference>
    <dbReference type="OMA" id="GEFDHHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="63" mass="6793" checksum="1FAC2BD558C6820D" modified="2017-01-18" version="1">MTGTEWQKSTFSGSTENCVEVRAASGAVELRESDEGHRILRTTPAALADLLHGIKAGEFDHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L9</accession>
    <name>A0A1E7N7L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550722.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2508"/>
    <dbReference type="EnsemblBacteria" id="ARF81496">
        <property type="protein sequence ID" value="ARF81496"/>
        <property type="gene ID" value="B6264_23580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36668">
        <property type="protein sequence ID" value="OEV36668"/>
        <property type="gene ID" value="HS99_0028290"/>
    </dbReference>
    <dbReference type="OMA" id="WNINIHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22220" checksum="19DFEDB8D15D5E29" modified="2017-01-18" version="1">MPFDHNDHYHPLLLRSVPPDARRALDVGCGTGAFARALARRGLEVDAVDRDESVLAAARASGGPAPIRYRQADLTALQLTPGHYDFISCLASLHHLPLDTLARLREALAPGGVLVVLGCYRETTPGDRLISLTAVPVNALCRLAVHLRERGAPPSRVRAPVTMPQTSLPEIRAYAERHLPGFRVRRLLFWRYLLAYRRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q2</accession>
    <name>A0A1E7N8Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000344.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81668">
        <property type="protein sequence ID" value="ARF81668"/>
        <property type="gene ID" value="B6264_24655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37062">
        <property type="protein sequence ID" value="OEV37062"/>
        <property type="gene ID" value="HS99_0004340"/>
    </dbReference>
    <dbReference type="OMA" id="HSHWLAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="359" mass="39865" checksum="E1D8C316F36D425F" modified="2017-01-18" version="1">MTITPTLVATYPIPDRDADTRTLLDPSGPVPRLHVRSAESLHIYELREQAELTARFPAPTPDRWTREWVTPDQSLAVFGTATEYVAVARNGRTVWKQPYGTWEVGRWGYVDFADPAHLAMTGTGQEPRTWLRLPSGLPDSTLILTLDAEGAELARSMLQCGGYGQFVGLLRDGNGEIRGVSVSDGRAPATHYEARCENGGIVLGRRLPQDGDGRPPSGRDHLGTDSQRTRCMTLDPRGRDVSWHDLPSYQVTASLTLSDFPAPGTGDCSVHNDPYISSPSGFVDDDTALVALYNPYDEAAVYLFGEERWRQHSHWLADPATGTLHGRVEYPVPEVDNVTPLGDGTWITQEWDAYHRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y7</accession>
    <name>A0A1E7N8Y7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetoacetate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386666.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6632"/>
    <dbReference type="EnsemblBacteria" id="ARF81584">
        <property type="protein sequence ID" value="ARF81584"/>
        <property type="gene ID" value="B6264_24145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37149">
        <property type="protein sequence ID" value="OEV37149"/>
        <property type="gene ID" value="HS99_0004845"/>
    </dbReference>
    <dbReference type="OMA" id="GRTIWGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33466" checksum="6606D0E3BDBD8A6A" modified="2017-01-18" version="1">MKPILSLARLGLSLVPSPYPRRQRRLAGRNALVDGIPFEMPVNSADTPCLMAAFTVDRAAAARLLPGGELHPVTLPGGRGLLMITVVNYVRTDIGRYIEYSIALACTHGNRPAPPLLPGLLRGVFGTGQYVLDLPVSSEISVKGGKGIWGMPKHQANLDFRVTDATVSSEYQVDGQLGTFISIDRPPATALPLRVKAANYCAFRGMLMKSSIYFEGEADIAFGKRARARLLLGDAPQVVALHDLGITSNPLFTIYLPSTRGVLDDHFECWFLTSEAPGQSYGEPMKSVVDLGLSQQWLDPPRIDVGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N933</accession>
    <name>A0A1E7N933_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gmd</name>
        <name evidence="5" type="ORF">HS99_0003805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557259.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000468.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene162"/>
    <dbReference type="EnsemblBacteria" id="ARF81756">
        <property type="protein sequence ID" value="ARF81756"/>
        <property type="gene ID" value="B6264_25210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36973">
        <property type="protein sequence ID" value="OEV36973"/>
        <property type="gene ID" value="HS99_0003805"/>
    </dbReference>
    <dbReference type="OMA" id="FVKSSWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="38530" checksum="30B6B1BB6E7A8117" modified="2017-01-18" version="1">MSKRALITGVTGQDGSYLAEHLISLGYQVWGLSRGQANPRKDRVSRLIPELRFVDGDLMDQGSLVSAVDTIQPDEVYNLGAISFVPMSWRQPELVTEVNGTGVLRVLEAIRMVSGINKPAATGDGTGQIRFYQASSSEMFGMVAETPQHETTRFHPRSPYGVVKTYGHYITRNYRESYGMYGVSGILFNHESPRRGAEFVTRKISLAVAQIKLGLQDRLLLGNLDAVRDWGFAGDYVRAMHLMLQQDEPGDYVIGTGRMHSVRDAARIAFECVGLDWEEHVEVDPALVRPAEVETLCADAQNARRVLGWEPTVDFTELMRMMVESDLEQARLARDYGEVLTGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B0</accession>
    <name>A0A1E7N9B0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0005590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366204.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1297"/>
    <dbReference type="EnsemblBacteria" id="OEV37269">
        <property type="protein sequence ID" value="OEV37269"/>
        <property type="gene ID" value="HS99_0005590"/>
    </dbReference>
    <dbReference type="OMA" id="CMDITEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="526"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="828" mass="87967" checksum="B92F92115122196E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E5</accession>
    <name>A0A1E7N9E5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37315">
        <property type="protein sequence ID" value="OEV37315"/>
        <property type="gene ID" value="HS99_0005875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11010" checksum="C613DB6B9E4A1B89" modified="2017-01-18" version="1">MEFDDPAVMRRLCGERLGPEAGPQFAAMARRGFRLAAASEKTPATGRSQLGGSALLEPGTPWPVLADVPLSLHAVLDTGTLYFTIPARAFAAGDFSKAEATGQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F8</accession>
    <name>A0A1E7N9F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555101.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000750.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37298">
        <property type="protein sequence ID" value="OEV37298"/>
        <property type="gene ID" value="HS99_0005770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198899" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="13840" checksum="BE184D9FEA20EB53" modified="2017-01-18" version="1">MQFKLGRRVASLAAVTALTVTGLGLASGSASAATGSDSNSAHGVEITGWHTLDDNPWVSARLCNYQSSANSFYFWIKDTAGDNVTSPGHITPVLAPGQCDYISGEDYGSTPIQVYARSGSSWTFGTDPIYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G5</accession>
    <name>A0A1E7N9G5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0005690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385428.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1277"/>
    <dbReference type="EnsemblBacteria" id="OEV37284">
        <property type="protein sequence ID" value="OEV37284"/>
        <property type="gene ID" value="HS99_0005690"/>
    </dbReference>
    <dbReference type="OMA" id="WCAACDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="169"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="48422" checksum="05ABCE1880350D5E" modified="2017-01-18" version="1">MSTYPEPPAAASADRPVHGSPCPRCAVPLTDDPRFLVWCPACDWNLVPDEDAAPGPTRRERAAAARTDRLYEEQAAGGHSPTARRDWLLASAAAGVIHLVTVGTFALALWLLITGTVVQRCVGAVVLVIAVTLRPRLGRLPKDVGVLDRAGAPALYGLADRVAAEVGARPVDVIQVTDEFNASYGLVGLRRRSVLRIGLPLWEVLDDRERTALLGHEFGHRVNGDRRRSFWLYSAVSALWAWYDMARPGHDGPVAGRDEVSMLVRLGAVFGRLVLRGVAWVLYQGLVLFDRLTSRAGQQAEYHSDVLAGRVAGGEAARGMLAALLLPGSVDTAIHRVRAEERGRPRIGRSRSRRTEDAPAPPAPDLLWERVREHLASVPAVERERLLRLSARDRSAVDGSHPPTHLRIALAARAGDGDAAVTVTAAESASITAELAPHRARIAAELLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9J4</accession>
    <name>A0A1E7N9J4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5427"/>
    <dbReference type="EnsemblBacteria" id="ARF82476">
        <property type="protein sequence ID" value="ARF82476"/>
        <property type="gene ID" value="B6264_29620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37362">
        <property type="protein sequence ID" value="OEV37362"/>
        <property type="gene ID" value="HS99_0006145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="10187" checksum="A1F10033ABC05427" modified="2017-01-18" version="1">MLMSEARNWKRALAASGGGGDGMVCLTAAALKDAAAVKGSVVSKTHATPLVCSPRKTGKTTIKTLYAVTSLAAETAIAAQRALELGPEKAVIGKLDISSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L5</accession>
    <name>A0A1E7N9L5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">HS99_0006265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385940.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5406"/>
    <dbReference type="EnsemblBacteria" id="ARF82495">
        <property type="protein sequence ID" value="ARF82495"/>
        <property type="gene ID" value="B6264_29740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37381">
        <property type="protein sequence ID" value="OEV37381"/>
        <property type="gene ID" value="HS99_0006265"/>
    </dbReference>
    <dbReference type="OMA" id="PDEGIQM"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="184"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="481" mass="53653" checksum="6F2EF6140444F49B" modified="2017-01-18" version="1">MTAPTSTAADVLVIFGITGDLARKMTFRSLYRLERRRLLRCPVVGVARQEWSATALLDHARHAIEDTGETIDEDVFQRFAQRLSMTSGDFGDPSTYDRLARTIETRHTPVFYLEIPPSLFGRVVEGLAGANLTAQARVVVEKPFGHDLASARALNAQLRRLLEEQQILRIDHFLGKEPSLDILFLRFANSVLEPLWNRDRIQCVQITMAEDFGVADRGSFYDPVGALRDVVQNHLLQLIGLFASEPPSTADADGLRDKRVEVFRAIPSADPRHYVRGQYDGYLAVPGVSPDSQTETYAALRLEIDNWRWSGVPIFIRAGKALPERVTEIRVVFKRPPGVAFAPTCAPDPNELILRIDPDPGVDLVVQAKQPGARATRTVDLSLIFSEELGEAPEPYERLLGDAMEGDSSLFTREDSVEETWRIVQPLLDAPPPVEPYKSGSWGPAGADKLLAGHPRWRDPWLHSRAMSQHRTQLDTPGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA52</accession>
    <name>A0A1E7NA52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286489.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000521.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1132"/>
    <dbReference type="EnsemblBacteria" id="ARF79012">
        <property type="protein sequence ID" value="ARF79012"/>
        <property type="gene ID" value="B6264_08860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37559">
        <property type="protein sequence ID" value="OEV37559"/>
        <property type="gene ID" value="HS99_0026495"/>
    </dbReference>
    <dbReference type="OMA" id="KDPQGPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="6972" checksum="FB0FD09C49DC2EED" modified="2017-01-18" version="1">MSTPAEHGTRWRKSSHSGGQGACVEIAGPAAGAVAVRDSKDPDGPQLRFSSEAWNAFASAVAAGAFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA64</accession>
    <name>A0A1E7NA64_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FxsB family radical SAM/SPASM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835523.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7953"/>
    <dbReference type="EnsemblBacteria" id="ARF82721">
        <property type="protein sequence ID" value="ARF82721"/>
        <property type="gene ID" value="B6264_09300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37585">
        <property type="protein sequence ID" value="OEV37585"/>
        <property type="gene ID" value="HS99_0026055"/>
    </dbReference>
    <dbReference type="OMA" id="HATWDDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026335">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04269">
        <property type="entry name" value="SAM_SPASM_FxsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="808" mass="85783" checksum="82574CF0DE7075C1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF6</accession>
    <name>A0A1E7NAF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280753.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1688"/>
    <dbReference type="EnsemblBacteria" id="ARF79923">
        <property type="protein sequence ID" value="ARF79923"/>
        <property type="gene ID" value="B6264_14320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37666">
        <property type="protein sequence ID" value="OEV37666"/>
        <property type="gene ID" value="HS99_0025530"/>
    </dbReference>
    <dbReference type="OMA" id="TEYSMSK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="25148" checksum="2255040DCF498549" modified="2017-01-18" version="1">MSEYDNVWLVIPAYNEGQVIAEVVEGARKTFPNIVVVDDGCTDDTAQHVMTTGAHLVRHPVNLGQGAALQTGLKYALEQEGAEYFATFDADGQHQTADVEKMVALLREGEADIVLGSRFIEQTGQVPWIKRVVLRTAAAVSPTARKLKLTDAHNGLRVMNREAASRIKITMNGMAHASEIVSFLAGSDLRVAEVPVDILYTDYSRAKGQSLINGVNILFDISLRERNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT9</accession>
    <name>A0A1E7NAT9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557057.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3745"/>
    <dbReference type="EnsemblBacteria" id="ARF78053">
        <property type="protein sequence ID" value="ARF78053"/>
        <property type="gene ID" value="B6264_03185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37812">
        <property type="protein sequence ID" value="OEV37812"/>
        <property type="gene ID" value="HS99_0024805"/>
    </dbReference>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="37572" checksum="BAC3246C1D42A208" modified="2017-01-18" version="1">MDQSETPGTARGRSRPPSQADVAALAGVSSQTVSRVANNRSNVEPETRERVLSAMRILGYQRNSAARALTLGRFHVLGVVTFDVAAHGNARTLAAISRAAQRAGYSLNVVCVEDRTEEAVQQAVRQLTEQAVDGLIVIEAQILDRPGLDLHSGVPVVVADGDPERRFPSVDTDQAAGATAATRHLLDLGHRTVWHVGGPQDSYAARRRAAAWHAALKAAGAPVPPLRYGDWTAASGYEIGLELAARPDVTAVFAANDQLALGLVRALHEAGRRVPQDVSVVGFDDLPEAAYYLPPLTTIRQDFEEVGRQCVAQLLAQIDRASDTPAAERIVTVTPDLVVRASTARAPEGSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV8</accession>
    <name>A0A1E7NAV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557045.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3737"/>
    <dbReference type="EnsemblBacteria" id="ARF78045">
        <property type="protein sequence ID" value="ARF78045"/>
        <property type="gene ID" value="B6264_03140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37819">
        <property type="protein sequence ID" value="OEV37819"/>
        <property type="gene ID" value="HS99_0024850"/>
    </dbReference>
    <dbReference type="OMA" id="ATWDDIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="37400" checksum="2A0B28B4D3049D39" modified="2017-01-18" version="1">MTGPLLDELDRRLIGALHVAPRATWDDIGAILSADAGTLKRRYDRLHKARMVRVVGQADWGLHSTAMPVHVFLDTTGETPLAVLERLRDLPHVQRLAQISGDYPLYAVIHAPSEAATSEAIDRLFSIPGVRRVNALPALSTLRRGATWDPRFLTDAERAGLLELAGVSPEGTATANPPAKPLSDAERSVVTQLIQDGRASAASIARSAALPTSTAHRVVRRVLDERWVKPRLEIVSEWLGFRTPFMLRLRVAPGETPEVMQRLDQLPQTRLAVHVASDLSVLCTGLVTDRSALAAFIDEELAEIPGILAVSVYVMLAEPRRYWLDRDLASGALGTFHAPTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB86</accession>
    <name>A0A1E7NB86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278316.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2059"/>
    <dbReference type="EnsemblBacteria" id="ARF79503">
        <property type="protein sequence ID" value="ARF79503"/>
        <property type="gene ID" value="B6264_11775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37949">
        <property type="protein sequence ID" value="OEV37949"/>
        <property type="gene ID" value="HS99_0024100"/>
    </dbReference>
    <dbReference type="OMA" id="CDLWLVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23235" checksum="96C4308B6F865025" modified="2017-01-18" version="1">MACDLWLVPLVDVLSHSPDNPFRDDLALYNAVLTSRGLPEVPVYQFVPGLSGAVEPIAAFDYDSLHFLRRAYLLGLTGLDITPVDSLGGDYEQLLEMFESSAEQSHLVWHFDHAGAYVPVEFQTPLVDEVLLASGGPLGSSHGLLRELQAVAPALGIDPLNPPDPTRPLGPTGLEQPFGPPIDDVHPFARERHAWSGLYAAATRSVSQGSMIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC4</accession>
    <name>A0A1E7NBC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552061.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2050"/>
    <dbReference type="EnsemblBacteria" id="ARF79512">
        <property type="protein sequence ID" value="ARF79512"/>
        <property type="gene ID" value="B6264_11820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37958">
        <property type="protein sequence ID" value="OEV37958"/>
        <property type="gene ID" value="HS99_0024145"/>
    </dbReference>
    <dbReference type="OMA" id="RMWAGCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="35340" checksum="B110E7602F58CCF9" modified="2017-01-18" version="1">METSKPGRPGDSVIEVTDLHRHYGTGATEYHAVRGVDLTVGRGELFALLGTNGAGKTSTLEVIEGLAAPSGGTVRVLGHDPFEERATVRPRIGVMLQEGGFPGELTAAETGRAWAGVTSGARPVAEALELVGLGHRAGVRVKQLSGGERRRLDLAMALLGRPEVLFLDEPSTGLDPEARTAVWRLVRELRAQGTTVLLTTHYLEEAEELADRLAIMHGGRVVTTGTVAEVIAGRPSRITFELPEFTGAALPVLPGAEVTVDGRKVTVQSTGLQDTLTDLLGWARHHGIALGALDARSASLEEAFLAIASEAAHQAPPQTPAAARPARRRLIGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBN6</accession>
    <name>A0A1E7NBN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288499.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000841.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3030"/>
    <dbReference type="EnsemblBacteria" id="OEV38068">
        <property type="protein sequence ID" value="OEV38068"/>
        <property type="gene ID" value="HS99_0022970"/>
    </dbReference>
    <dbReference type="OMA" id="RFSYSHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21657" checksum="8FA537AE4663B8A0" modified="2017-01-18" version="1">MGLFNRTKTATTATVQAPAGPDLSHLTGDWTVDAMHSEIGFSVRHAMVTNVKGRFTEYDGKLHLDGATPGNSSADLVIKVASIDTNQAQRDEHLRTGDFFAAETYPEIRFRSISTEAVGEDSYRMNGELTIKDTTRPVVLDLEYTGSATDAYGAERVGFEGKAVVDRTDFGLTYNAALETGGVLIGEKVKLSFDISAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR5</accession>
    <name>A0A1E7NBR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386725.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000474.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7133"/>
    <dbReference type="EnsemblBacteria" id="ARF79644">
        <property type="protein sequence ID" value="ARF79644"/>
        <property type="gene ID" value="B6264_12665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38146">
        <property type="protein sequence ID" value="OEV38146"/>
        <property type="gene ID" value="HS99_0023425"/>
    </dbReference>
    <dbReference type="OMA" id="EMPVQET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="38497" checksum="3736C45A9931B954" modified="2017-01-18" version="1">MARTPGQAARRDPDWEGVRLHVVSGKGGTGKTTLAAALALALAADGGRVLLIEVEGRQGIAELFGIAALPYEERRIASVSPSQLGLPAGEVPAGGARAGEVLALAIDTEQALLEYLEMFYKLGRAGKALQKVGFVDFATTIAPGVRDVLLTGKACEAARRKGPDGRRRYDAVVMDAPPTGRITRFLNVNSEVAGLARIGPIHTQAQAVMRVLRSPETAVHLVTLLEEMPVQETVDGIAELREAKLPVGGVMVNMVRPPVLDAAAVAAVDGDHREEVALALGEAGLGGRSRRTETVRAAVEPLLDPLLEQAREHAERVELEREQRADLQQLRLPTYELPLLGEGVDLGGLYRLAGELKRQGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC81</accession>
    <name>A0A1E7NC81_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80181">
        <property type="protein sequence ID" value="ARF80181"/>
        <property type="gene ID" value="B6264_15805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38301">
        <property type="protein sequence ID" value="OEV38301"/>
        <property type="gene ID" value="HS99_0022465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6501" checksum="9D3031B9C119CDD3" modified="2017-01-18" version="1">MTAAASAFFRSATWMWSSSLLKKSPTVSLILSQLPGSSGISRLAWAIASDMLWRVLAASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB9</accession>
    <name>A0A1E7NCB9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283971.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4138"/>
    <dbReference type="EnsemblBacteria" id="ARF80149">
        <property type="protein sequence ID" value="ARF80149"/>
        <property type="gene ID" value="B6264_15605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38327">
        <property type="protein sequence ID" value="OEV38327"/>
        <property type="gene ID" value="HS99_0022670"/>
    </dbReference>
    <dbReference type="OMA" id="THTSMRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="43729" checksum="0560B97551295410" modified="2017-01-18" version="1">MARKIGSRYTVHQVIGRGSAGTVWLGEGPDGPVAVKLLREDLAADQVLVGRFVQERTALTSLDHPRVVGVRDMVVDGSDLALVMELVQGTDLRSRLERDGALPPQVAASVIADVADGLAAAHAAGIVHRDVKPENVLLDLAAAPGPGGAPRAKLTDFGVARLVDAPRRTRATRIIGTPDYLAPEIIEGLEPRAAVDIYALATVLYELLAGFTPFGGGHTGAVLRRHVTEQVPPIPGLPDGLWRIISECLAKAPASRLRAAELAARLREQLPSLAGLPVLAVPSQGRAPAEEQLSPGEAVYAEVDAGPGVHKRRRGPAVPLVPGAAPDSTRDTHTSLRRPSAEELAAYAAESRAQRAAPGHRRDRAALLRRRRMLAVLLATVLLLAGAAAAWTAFAAPEPGAGHPARPAVHSTAPRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI2</accession>
    <name>A0A1E7NCI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554455.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene251"/>
    <dbReference type="EnsemblBacteria" id="ARF82222">
        <property type="protein sequence ID" value="ARF82222"/>
        <property type="gene ID" value="B6264_28080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38387">
        <property type="protein sequence ID" value="OEV38387"/>
        <property type="gene ID" value="HS99_0020975"/>
    </dbReference>
    <dbReference type="OMA" id="ACRDTER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="35439" checksum="8EF6BC43E46FBB20" modified="2017-01-18" version="1">MANTSTRTLRLLSLLQTHRYWPGEELADRLGVSVRTLRRDVDRLRELGYPVEAQRGVDGGYQLAAGAALPPLVIDDEEAVALAVGLQAAAESPVEGVAEASVRVLAKVVQVMPARLRRRVEALRAVTVPVDWGASAGSGVDPDALTAVALACRDSERLRFSYTAATANRSDRHVEPHRLVCLGRRWYLVAYDLDRGDWRTFRLDRLTAAEGTGARFAPRTLPAADAAEYVRAGLNATPRSNRVEALVEAPADHVRAHVGRWGEVEEVDATRCRLRMTADSLDWPAMALGSLAADFQIIHPPELRTLIADWSTRFARAVERPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP0</accession>
    <name>A0A1E7NCP0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Maleate isomerase</fullName>
            <ecNumber evidence="1">5.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Maleate cis-trans isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">maiA</name>
        <name evidence="2" type="ORF">HS99_0021410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>maleate = fumarate</text>
            <dbReference type="Rhea" id="RHEA:13169"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30780"/>
            <dbReference type="EC" id="5.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the maleate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene339"/>
    <dbReference type="EnsemblBacteria" id="ARF82143">
        <property type="protein sequence ID" value="ARF82143"/>
        <property type="gene ID" value="B6264_27640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38460">
        <property type="protein sequence ID" value="OEV38460"/>
        <property type="gene ID" value="HS99_0021410"/>
    </dbReference>
    <dbReference type="OMA" id="NTTMEME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050076">
        <property type="term" value="F:maleate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00943">
        <property type="entry name" value="Maleate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026286">
        <property type="entry name" value="MaiA/AMDase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028615">
        <property type="entry name" value="Maleate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40267">
        <property type="entry name" value="PTHR40267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17645">
        <property type="entry name" value="Amdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015736">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="S-(2-succinyl)cysteine" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="26388" checksum="9C0495C74FF3C3A1" modified="2017-01-18" version="1">MTTYRIGQIVPSSNVTMETEVPALLRAREAVAPERFTFHSSRMRMTRVTPEQLRAMDAESDRCAAELSDARVDVIGYACLVAVMATGPGYHREAEQRLHRRTVENGAPAPVVTSAGALVAGLRTLGAKKVAMVTPYLRPLARTVVDYLAQEGIEVLDHAALEIADNLDVAAHDPARLPAIAKGLSHGGADAVVLSACVQMPSLSAVEETEQQLGKPVVSAAICTTHQLLRALGLPAVAPGAGHLLSGAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND21</accession>
    <name>A0A1E7ND21_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene642"/>
    <dbReference type="EnsemblBacteria" id="ARF77615">
        <property type="protein sequence ID" value="ARF77615"/>
        <property type="gene ID" value="B6264_00590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38589">
        <property type="protein sequence ID" value="OEV38589"/>
        <property type="gene ID" value="HS99_0020175"/>
    </dbReference>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="36826" checksum="9279C1390C21E819" modified="2017-01-18" version="1">MPVLTRLVPSPLFAEIRPGALDALGGILADQRLSASGRIAVAISNGSGAAMRERLEPALPGADWYNVDDGSLDSAVRFAEEMRGRHYDAVVGLGGGKIIDAAKYAAARVGLPVVAVATNLAHDGICSPVSTLDNDAGRGSYGVPSPIGIIVDLDVIRQAPQRFVAAGIGDVVSNISACADWELSHTVTGEPVDGLAVAMARSAGENLLRHPGSTQDQDLLTALAEALVLSGIAMNIAGSTRPSSGACHEISHALDVLYPKRSAQHGEQVGLGAAFASFLRGERELTGLVVERLARHGLPVTAAQIGFTEAEFTEAVHYAPNTRPGRYTILEHLDLSPSAIRDAYADYVQAVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDA7</accession>
    <name>A0A1E7NDA7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737796.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene583"/>
    <dbReference type="EnsemblBacteria" id="OEV38634">
        <property type="protein sequence ID" value="OEV38634"/>
        <property type="gene ID" value="HS99_0020475"/>
    </dbReference>
    <dbReference type="OMA" id="PEAEANW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="21771" checksum="8F61F9369170FAE8" modified="2017-01-18" version="1">MAVALIAAGGLGGAALYNSTGQRVAVLALARDVPWGQVITDDDLVVARIAGDPALHPVSAQDRSKAVGMRAATDLKRGSMLTGSDLAQGQTVQPGQIVVGVSAKRTQLPASRLQPGVQIVVVNTPDNGRPDSLAATVITVGRVDTDGSQVIDVAVGSADGPRLAQWVAGGRIQVLLAPRGSAAGGSGPAGSGAPASPSAAPSAASTGTAPSGGAGAPAAPAGTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT6</accession>
    <name>A0A1E7NDT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737786.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6289"/>
    <dbReference type="EnsemblBacteria" id="ARF81237">
        <property type="protein sequence ID" value="ARF81237"/>
        <property type="gene ID" value="B6264_22140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38834">
        <property type="protein sequence ID" value="OEV38834"/>
        <property type="gene ID" value="HS99_0019405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15708" checksum="DDBE775F7D685327" modified="2017-01-18" version="1">MNSPTSPNGSSPADQSGRAGTDAVRRDTASAVFEEAQSSPSFGRLRRSQRTFATLATIAVLSLYLLYVLLSSYARDLMDARVVGRLNVAFFLGLAQFGATFLTAWLYTRHADRRRDPVAEQVRQDIERVLVAGSYGSGQTTGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV0</accession>
    <name>A0A1E7NDV0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6523"/>
    <dbReference type="EnsemblBacteria" id="ARF81294">
        <property type="protein sequence ID" value="ARF81294"/>
        <property type="gene ID" value="B6264_22455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38886">
        <property type="protein sequence ID" value="OEV38886"/>
        <property type="gene ID" value="HS99_0019720"/>
    </dbReference>
    <dbReference type="OMA" id="EVVFARW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13867" checksum="54F0821B3D5CA6CC" modified="2017-01-18" version="1">MTNVLPDAELMHGYDVEAAITRGLLIDGVTRQVLFGEAAIAASYQAEALRIGPYPLGFLAQYVRTGGFSAALDLPEPVIGREAGELVRGWLRAAAGAGANLQREVVFARWLAEVALLITMRRDVRGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ0</accession>
    <name>A0A1E7NEJ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0018345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557490.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000084.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1002"/>
    <dbReference type="EnsemblBacteria" id="ARF83291">
        <property type="protein sequence ID" value="ARF83291"/>
        <property type="gene ID" value="B6264_30630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39058">
        <property type="protein sequence ID" value="OEV39058"/>
        <property type="gene ID" value="HS99_0018345"/>
    </dbReference>
    <dbReference type="OMA" id="WLDQVAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="54226" checksum="2954A8CF33237887" modified="2017-01-18" version="1">MSESVRRVLAGWVPDWPVVAVLGREPEPQCLAAVTERGRILAASGAARAAGVRGGQKLRSAQALVADLEVFDRDPDLEVQAFEPVADAVGALAAHLEVVRPGLLALAAGGAARFHGGEEALAERVMDAVEAMGHPCRVGIADGLFAARLAARVQQIVPVGASARFLAPYPVAELGEPRLADLLGRLGLATIGQFAALPTASVADRFGQAGVLAHRLARGLEARPVVARPPGADLTAEQRFDEPVLLAEPLVFTARALAERLHEHLAAAGLACERVDVEVECADGTTASRTWRHEGVLSVGAVAERVRWQLQAWQQRDLFDEASGGVVALRLVPDGLVKDPGRQLSLEDGDQEARARAERAVARVQAILGHSAPVTVDLAGGRAPGDRVVHTPWGDAHQERRADGPWPGRLPAPSPTHLPAQPAAVRLLDAGGHDVEVSARAEVRSAPARLVLPGGVSRVVAWAGPWPEQERWWDPEQARRTARMQVVVDDGRALLLAVTGGRWIIEGDYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ0</accession>
    <name>A0A1E7NEQ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557309.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000100_gene7485"/>
    <dbReference type="EnsemblBacteria" id="OEV38963">
        <property type="protein sequence ID" value="OEV38963"/>
        <property type="gene ID" value="HS99_0017780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="9285" checksum="B9C41AC877502104" modified="2017-01-18" version="1">MTRASARSTSSWSPRTATPGTGTWRLEGGAGLDAAAAVLGMVRSEMGSTARGAGRSGAQHAMAVNETALAFILGGSAPGWVLPALQDDPASAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NER4</accession>
    <name>A0A1E7NER4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550113.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000490.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39189">
        <property type="protein sequence ID" value="OEV39189"/>
        <property type="gene ID" value="HS99_0000190"/>
    </dbReference>
    <dbReference type="OMA" id="HCEIAGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="10585" checksum="42F317FEAAF99CC9" modified="2017-01-18" version="1">MSIECVRRVDGLVYRYRRDGEFNGRPSFKRVDLDVWCRWLPVRGWCTVGADGAANGWPLHGGSGDRRFPPPGPWRSWKAGRSYLYDLRRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV6</accession>
    <name>A0A1E7NEV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285091.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3472"/>
    <dbReference type="EnsemblBacteria" id="OEV39165">
        <property type="protein sequence ID" value="OEV39165"/>
        <property type="gene ID" value="HS99_0000060"/>
    </dbReference>
    <dbReference type="OMA" id="PYDDFPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="25419" checksum="8D230B0908ACB8E4" modified="2017-01-18" version="1">MSTRFADKSVLVTGGGSGIGRGIALAFAREGARVAVAGRGAGPLAETVALIEAAGGKAVALTGDVTNSADAARLVRETVERFGGLDVAVNNAGVFGAAGPVAEIDEDEFRRVVEINVTGTLLAMKHQIGHMRAHGGGAIVNVSSNLGVHRRLEGVGAYAVSKAAVTALTRAAARDHIGEGVRINTVSPGPVDTPMSSRPGESDADKSDRMKSEVPVGRSGAIAEIAAAVLYLASPEAGYTVGADLVLDGGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX8</accession>
    <name>A0A1E7NEX8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1021"/>
    <dbReference type="EnsemblBacteria" id="OEV39043">
        <property type="protein sequence ID" value="OEV39043"/>
        <property type="gene ID" value="HS99_0018260"/>
    </dbReference>
    <dbReference type="OMA" id="GSGQTCW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14964" checksum="898A6D2B371B2732" modified="2017-01-18" version="1">MSNKPWIVDDELWTRVEPLLPAWPERSPGPRPVDDRRCLQGILFVLYTGITWRQLPLELGFGSGQTCWRRLGRWQEAGVFEALHCILLAELNAAGLIDWTRACVDASHVRAKKGARPPARHRSTAARPAANTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF26</accession>
    <name>A0A1E7NF26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ni/Fe hydrogenase formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3650"/>
    <dbReference type="EnsemblBacteria" id="OEV39309">
        <property type="protein sequence ID" value="OEV39309"/>
        <property type="gene ID" value="HS99_0000925"/>
    </dbReference>
    <dbReference type="OMA" id="EEFGDPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10588" checksum="9156415568F8CB93" modified="2017-01-18" version="1">MCLAVPGRVAEVYERDGTRMARVDFGGVLKEVCLEYLPEIAVGDYAIVHVGFALQRLDEESALATLRLFEEIGALEEEFGDAWARARAEAQPEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF40</accession>
    <name>A0A1E7NF40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285017.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3591"/>
    <dbReference type="EnsemblBacteria" id="ARF82456">
        <property type="protein sequence ID" value="ARF82456"/>
        <property type="gene ID" value="B6264_29495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39258">
        <property type="protein sequence ID" value="OEV39258"/>
        <property type="gene ID" value="HS99_0000630"/>
    </dbReference>
    <dbReference type="OMA" id="QRVFFHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="12330" checksum="02D84722127B32F1" modified="2017-01-18" version="1">MSTPSTPVVERSDALHRYEVRVDGELAGFTEYLDHDGQRVFYHTLVEDAFAGRGLAGQLVRAALTDVRAAGKRIVPVCPYVAKFLVKHEEFSDIADEVTPEVKGWLRSQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE4</accession>
    <name>A0A1E7NFE4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molecular chaperone DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286014.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene556"/>
    <dbReference type="EnsemblBacteria" id="OEV39407">
        <property type="protein sequence ID" value="OEV39407"/>
        <property type="gene ID" value="HS99_0001520"/>
    </dbReference>
    <dbReference type="OMA" id="WDAGFEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="34227" checksum="EAACB4A0AA60728D" modified="2017-01-18" version="1">MARDFYEVLGVPRDADEDEIQRAYRKLARKYHPDVNRDPAAEERFKEINEAFSVLSDPNQRGRYDRFGEDFRKVPEDWEERVGAGAGPGGGFRWSTGGGPRVRYATSGFGAEGVDVDDLFGSIFGGAGRVRVPGADQEAELPLTVEEAYRGGRRTVTLAGPSGQPRRYEVDVPPGVTDGQRIRLAGEGGRGNGDAPAGDLYLRVRIQPHPQFRLEGRDVYVQLPVTPWEAALGATVPVPTPSGATAKVTVPTGSSSGRRLRLRGEGMPNPRGADGNLYAELRIMVPSRFSDRERELFEELAAVSSFDPRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG09</accession>
    <name>A0A1E7NG09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550368.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2793"/>
    <dbReference type="EnsemblBacteria" id="OEV39649">
        <property type="protein sequence ID" value="OEV39649"/>
        <property type="gene ID" value="HS99_0002995"/>
    </dbReference>
    <dbReference type="OMA" id="QGVDCFK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="760" mass="84178" checksum="6CE0B4C75E9EFBF5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVB0</accession>
    <name>A0A1E7MVB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289594.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6966"/>
    <dbReference type="EnsemblBacteria" id="OEV32372">
        <property type="protein sequence ID" value="OEV32372"/>
        <property type="gene ID" value="HS99_0016880"/>
    </dbReference>
    <dbReference type="OMA" id="QPRTCDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipase_3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="30069" checksum="2B1F43A145D9EB21" modified="2017-01-18" version="1">MAVPTTFDRNATGYSLAHAYNLARAADLAYEDDATIDRQAHDWGFDTVRHHDTRFTPPFPLEDTQAYTMASDRMIVVAFRGTEPREIRDWLTDSTTPPWPGPAGTGYVHYGFAEALESVFPDVLKTLAELRDNDQTVWITGHSLGGALAMLAAARLSLEDPRLTADGVYTFGQPRTCDRLLTAAYNKALKGRSYRFVNNHDVVPQLPPEPAFTHIEALRFIDSAGTVHDGASSLISGLATRARSLTSAAFEPTGEGVRDHFMHSYLAALEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVN6</accession>
    <name>A0A1E7MVN6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289652.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000621.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6911"/>
    <dbReference type="EnsemblBacteria" id="OEV32323">
        <property type="protein sequence ID" value="OEV32323"/>
        <property type="gene ID" value="HS99_0016605"/>
    </dbReference>
    <dbReference type="OMA" id="TRHGTPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016538">
        <property type="entry name" value="UCP008292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008292">
        <property type="entry name" value="UCP008292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="25245" checksum="613896C3247F77D8" modified="2017-01-18" version="1">MIRVAAVGDIHLGPDSRGLLRPAFATLDELADVLLLAGDLTRHGTPEEAAVVGEEVGGLPVPVIAVLGNHDYDAGRPEEVTRILASHGVQVLERSSTAVRVDGTLVGVAGTKGFGGGFAGRSAGEFGEPEMKAFVRHSRECADGLRTALDRLAAEGCDLRIALTHFAPVPDTLAGEPTEIHPFLGSYLLAEAIDGAGADLALHGHAHLGTERGLTACGVRVRNVAQPVIGRAFAVYRLHPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT4</accession>
    <name>A0A1E7MVT4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289592.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6967"/>
    <dbReference type="EnsemblBacteria" id="OEV32373">
        <property type="protein sequence ID" value="OEV32373"/>
        <property type="gene ID" value="HS99_0016885"/>
    </dbReference>
    <dbReference type="OMA" id="RWASKHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22088" checksum="2B2BCE053D390212" modified="2017-01-18" version="1">MSAEARTAGHGTERAAATAAPVRRRGEALESAIYGAVLQQLTTDGYARLTMEGVAAAAQTGKAALYRRWSSKEELVMDALRASLPPAGAAPDTGSLRGDLLAVVTGLRTAMFSELGAAVRAIMSEMDHQRARAFLELVLERVVEPTTALIAEVLDRGTARGEVRPGAVTPLVTDVVPALMLYRIKMCGGGAVELDPAAIVDEVLLPIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW10</accession>
    <name>A0A1E7MW10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3829"/>
    <dbReference type="EnsemblBacteria" id="ARF78350">
        <property type="protein sequence ID" value="ARF78350"/>
        <property type="gene ID" value="B6264_04935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32610">
        <property type="protein sequence ID" value="OEV32610"/>
        <property type="gene ID" value="HS99_0015145"/>
    </dbReference>
    <dbReference type="OMA" id="AFDSCII"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="4164" mass="450734" checksum="00D4A14D8206C368" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW47</accession>
    <name>A0A1E7MW47_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0015400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554901.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3143"/>
    <dbReference type="EnsemblBacteria" id="ARF78305">
        <property type="protein sequence ID" value="ARF78305"/>
        <property type="gene ID" value="B6264_04680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32655">
        <property type="protein sequence ID" value="OEV32655"/>
        <property type="gene ID" value="HS99_0015400"/>
    </dbReference>
    <dbReference type="OMA" id="EHNQAVQ"/>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="48657" checksum="F6261248847D7C33" modified="2017-01-18" version="1">MSDAQVVVVGGGIAGLAAAAFLSGAAGGPARARVTVLEASGRVGGKLWGGEVGGVRVDLGAESVLARRPEAVELARAVGLGEELEPPTTAKAAIWTRGALRPLPGGQVMGVPGDLEALAASGVLTAEGLERARSERPTEVGADVAIGRYVADRLGREVVDRLVEPLLGGVYAGRADEISLRAAVPQLLPIARGGGSLVEGVHELASRPQVVGTPVFQGLRGGLGTLPEAVAAACVRAGVDLRTDTPVEELRRTPEGWRVVAGGEVLTADAVVLAVPAPAAARLLRADAPAAAVELDTVEYAGMALVTLAFRRGDLAEPPSGSGFLVPPVDGRRIKASTFSSNKWGWLERSAPDAFLLRTSLGRHREDEVLELPDEELVARSLADLEEAVGLTARPYDTFVSRFTAGLPQYPVGHLDRVARVRAAAEAVGALALCGAAYDGVGIPACIASAAAAAAAIDKLLTPATGEGSTERTMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW84</accession>
    <name>A0A1E7MW84_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0015525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288276.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3169"/>
    <dbReference type="EnsemblBacteria" id="ARF78283">
        <property type="protein sequence ID" value="ARF78283"/>
        <property type="gene ID" value="B6264_04560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32679">
        <property type="protein sequence ID" value="OEV32679"/>
        <property type="gene ID" value="HS99_0015525"/>
    </dbReference>
    <dbReference type="OMA" id="TIDCACH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="14524" checksum="0CBA1B151DF60AD6" modified="2017-01-18" version="1">MSEAPETSPATSRRTLLCGAAAVLAAGGTVAVTGCSSSAGSSEKSSAPQGAVDLGPASAIPEGGGKVFREQKIVVTQPAAGQFKAFSAKCTHAGCIVDQVKQEQIQCPCHGSRFGIADGAVQDGPAPSPLPAYAVTVEGGNLKVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM0</accession>
    <name>A0A1E7MWM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0039930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000084">
        <property type="protein sequence ID" value="OEV32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2559"/>
    <dbReference type="EnsemblBacteria" id="OEV32830">
        <property type="protein sequence ID" value="OEV32830"/>
        <property type="gene ID" value="HS99_0039930"/>
    </dbReference>
    <dbReference type="OMA" id="DYAHTIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198498" evidence="8">
        <location>
            <begin position="32"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="47333" checksum="08CEDC7D173C1EB5" modified="2017-01-18" version="1">MLTRTSLTCALAVAALAVALALTVTGGGTLADRSPLYDWYTLDAALFVLALLLLRKVSRRHVVPLVLTGSVLVAAAGLLAPPRTSDDAYRYVWDGRVQAAGLSPYAYTPDDPALVRLRDAGLFPVGDGCATWDERRTAAGDCTRINRPAVHTVYPPVAEAWFLAAHPFGGGVRGAQAAGALLAVATTGVLLAVGRGSRRAALWGWCPGVTVWAVNDAHVDTLGALLMVAGLGCAARRRAGAGGALLGAAVATKLLPALALPGAVSGLLARRPTKGDLTVLAAALGTFLLAYLPYVAVSGSGVLGYLPGYLREEGYEQGHLDRFGLLRVVVPDRWAAWAAALALGAVVLWVLRRGDPHRPWRGALLVTGTALLLVAPSYPWYGLLVVALVALDGRWEWLAVPAAGQALYLVGGPQAQRTAYAAALACVLVVPALRRLVSAAPVRSARGAAPEMTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY6</accession>
    <name>A0A1E7MWY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552575.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5785"/>
    <dbReference type="EnsemblBacteria" id="ARF81339">
        <property type="protein sequence ID" value="ARF81339"/>
        <property type="gene ID" value="B6264_22695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32929">
        <property type="protein sequence ID" value="OEV32929"/>
        <property type="gene ID" value="HS99_0013675"/>
    </dbReference>
    <dbReference type="OMA" id="TWINTAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="567" mass="60059" checksum="AF79890008195F10" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX24</accession>
    <name>A0A1E7MX24_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279862.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5696"/>
    <dbReference type="EnsemblBacteria" id="ARF81423">
        <property type="protein sequence ID" value="ARF81423"/>
        <property type="gene ID" value="B6264_23150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33005">
        <property type="protein sequence ID" value="OEV33005"/>
        <property type="gene ID" value="HS99_0014120"/>
    </dbReference>
    <dbReference type="OMA" id="HGLFHLE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19478" checksum="3719E948C8010CCF" modified="2017-01-18" version="1">MSVPLTLLGLLEREPSHGYDLKRDYDSLFGRGKPLPYGQVYATLGRLARDGKVMAGEAEPGDGPERKRYVITETGATEFETWLRDPVAPEPNLQSVLFTKVVLALMLGRDAEQYLDTQRAAHLRRMRELTELRRGGPLVDALLADHGLFHLEADLRWIDLTVARLDALAAEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX69</accession>
    <name>A0A1E7MX69_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5690"/>
    <dbReference type="EnsemblBacteria" id="OEV33011">
        <property type="protein sequence ID" value="OEV33011"/>
        <property type="gene ID" value="HS99_0014150"/>
    </dbReference>
    <dbReference type="OMA" id="ACWRPLF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046037">
        <property type="entry name" value="DUF5995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19458">
        <property type="entry name" value="DUF5995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="29140" checksum="B7AF3C22BA33EAE9" modified="2017-01-18" version="1">MTIEEVVDRLREIAAALPLADGVAVFNRLYLTVTEAVRDRLADGYFADPPAMAELDAVFAGRYLLAVAADGAGQQPPACWRPLFALRAHPGVHPLQFALAGMNAHIQHDLPLAVVDLCRRRGCEPADVERDYHRINGVLAEVESVVREQLLPGPELLDCAEPLTHLLGAWSVEAAREGAWSAVRALWELRGLPAATGAFTAALDGSVGLLGHALLLPLVPYERCAGRTGQNEQHGRSDDAPGTTAAARLPEAGCRAAAGTGAGDQAQLECSGLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC4</accession>
    <name>A0A1E7MXC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279738.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81480">
        <property type="protein sequence ID" value="ARF81480"/>
        <property type="gene ID" value="B6264_23495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33064">
        <property type="protein sequence ID" value="OEV33064"/>
        <property type="gene ID" value="HS99_0014465"/>
    </dbReference>
    <dbReference type="OMA" id="WEGGVHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="480" mass="50854" checksum="72C17CAF4E3C055F" modified="2017-01-18" version="1">MSADTNKQAADTTDVPHPLGPVGHGGDGHLKAGLKNRHLSMIAIGGVIGAGLFVGSGAGIASTGPGILLSYTLAGVLVVLVMRMLGEMAAADPQSGSFSAYADRALGRWAGFTIGWLYWFFWVVVLAVEATAGAKILNTWVPGVPQWGWALIVMGVLTATNLFSVASYGEFEFWFAGIKVVAIAAFLVIGTLAAFGLMPGTHAVGTSNLTGQGGFLPHGVGAVFTGMLTVVFAFMGSEIVTLAAGESEDPEKAVSKATNSVIWRIGIFYLGSILLVVTLLPWNSAEVKASPYVAVLDHVGIPHAGQVMDVIVLTAVLSCLNSGMYTASRMAFSLGQRGDAPKAFATVTSRGVPRVAILSSVVFGFVAVFFNYTSPKTVFAFLLNSSGAIALFVWLVICATQLRMRKIIEREMPERHTVRMWLYPYLTWFAIGMIGFVVVYMFTDHDGRQQMYLSLVAAAIVLGASAVVGRRRRAAVAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH3</accession>
    <name>A0A1E7MXH3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0014885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550924.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000537.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2678"/>
    <dbReference type="EnsemblBacteria" id="OEV33132">
        <property type="protein sequence ID" value="OEV33132"/>
        <property type="gene ID" value="HS99_0014885"/>
    </dbReference>
    <dbReference type="OMA" id="AYGFDGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198618" evidence="6">
        <location>
            <begin position="27"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="577"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="664"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="818" mass="87062" checksum="203166BB767F38BE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXN3</accession>
    <name>A0A1E7MXN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0039325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000073">
        <property type="protein sequence ID" value="OEV33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7575"/>
    <dbReference type="EnsemblBacteria" id="OEV33210">
        <property type="protein sequence ID" value="OEV33210"/>
        <property type="gene ID" value="HS99_0039325"/>
    </dbReference>
    <dbReference type="OMA" id="TFRWEED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1789"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1954" mass="202868" checksum="DFF4DE6EA4A72166" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXT7</accession>
    <name>A0A1E7MXT7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vitamin K epoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0014395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279764.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5641"/>
    <dbReference type="EnsemblBacteria" id="ARF81468">
        <property type="protein sequence ID" value="ARF81468"/>
        <property type="gene ID" value="B6264_23425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33053">
        <property type="protein sequence ID" value="OEV33053"/>
        <property type="gene ID" value="HS99_0014395"/>
    </dbReference>
    <dbReference type="OMA" id="WYWLTFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12922">
        <property type="entry name" value="VKOR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041714">
        <property type="entry name" value="VKOR_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23150" checksum="05EB4245CDAE50A7" modified="2017-01-18" version="1">MTATTAHLSRPAPDAAGPGPIGAGRALALLLFLGGLVGLAASAVLTFDKLRILENPSYVPSCNINPIISCGSVMRTEEAAVFGFPNSLLGLAAFGALAAVGAGLLAGAAYRRWFWLGLQAGTTLGIVFTHWLIDQSLYGIGALCPYCMVVWATTVVLFWYTTLHNLRTGVIPVGPRMRTVVREAARYHWALPVLWAAVIALMVLNRFWYYWSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXW5</accession>
    <name>A0A1E7MXW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283772.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000861.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4502"/>
    <dbReference type="EnsemblBacteria" id="ARF82879">
        <property type="protein sequence ID" value="ARF82879"/>
        <property type="gene ID" value="B6264_17145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33276">
        <property type="protein sequence ID" value="OEV33276"/>
        <property type="gene ID" value="HS99_0038925"/>
    </dbReference>
    <dbReference type="OMA" id="FIPCRDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="447" mass="49540" checksum="DD1ADF53AC0C2C80" modified="2017-01-18" version="1">MAFVFGRFLVYWAGSRHAFRHNRPAEPGDPSAFQWHLVIPCRDEEAVVTQTLDGLRAAAPEAHLWVIDDDSEDATRELVLAAAARDPRVHLVQRRRPHARIGKGAPLNAAYREISARLPGSTDRSRVVIGVVDADGQLDPGTLGQVCNPKALGRPDTGAVQIGVRMRKADDERPLPGRGRTANALARALVRMQDVEFQANNAGMQLLRRRTGSVGLGGNGQFVRLTALDSLTAEEGRAGRPWPERALLEDYESGLDLRLAGWRLTHVTEAQVSQEGLISLRRFLTQRTRWAQGNMQCLRYTGRVLRSPHYTVSGKAEVLYTFLQPVVCVLLVLLFPLSLAITTAGLVLFPAATAEFQLRFGPWMLLVLVLATLPMVLWGLAYRRTVHPDRRRLTGLLWGVLVWLYAYHLFVVASRAAVRMLLGRNGWAKTRRNAEKVAVGAPTALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB8</accession>
    <name>A0A1E7MYB8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pirin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553429.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3973"/>
    <dbReference type="EnsemblBacteria" id="OEV33411">
        <property type="protein sequence ID" value="OEV33411"/>
        <property type="gene ID" value="HS99_0012585"/>
    </dbReference>
    <dbReference type="OMA" id="HTEIVTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="PTHR43212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin" evidence="4">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="27826" checksum="51F69A5B9538A606" modified="2017-01-18" version="1">MTDAPERPRADLRRTAERYRSTPAEGIETRHAFSFSGHYDPKNTHFGALLACNEELLAPGAGFEEHKHRDTEILTWVLEGALAHRDSRGHSGVVRPGMIQHLSAGSGVTHTERNLGGATGPVRFVQMWLQPDELDATPGYGLRRVEPADGGLTLLASGMERDAGTDALRLRRRDAALWLATAGPWQPLPQLPAAPWRYAHLTAGSLGYRTIPGPKGGGRSMEPGDSVRITGEAFADPAAGGTGAELLLWEMHSPVSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP4</accession>
    <name>A0A1E7MYP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549972.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5242"/>
    <dbReference type="EnsemblBacteria" id="ARF80661">
        <property type="protein sequence ID" value="ARF80661"/>
        <property type="gene ID" value="B6264_18685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33557">
        <property type="protein sequence ID" value="OEV33557"/>
        <property type="gene ID" value="HS99_0013465"/>
    </dbReference>
    <dbReference type="OMA" id="MGRLSHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19255" checksum="824BBD5E94070287" modified="2017-01-18" version="1">MTQPEFPTGAVRPSDSERDQALGVLRDGAGSGRLSHDTFLGRMDIVLQATSRGELDAAVAGLPTGGPVERFVLRAVGRVSAFGDRLNRAWRSERLPGLSLPQAGAGLLTIGRIPGSGLRLHDASVSRHHAELRHENGGWVLYDLGSTNGTHVNGRRIAGGIPVRPGDQVRFGNLEFRLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU2</accession>
    <name>A0A1E7MYU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290183.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33620">
        <property type="protein sequence ID" value="OEV33620"/>
        <property type="gene ID" value="HS99_0038650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198572" evidence="1">
        <location>
            <begin position="36"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="35434" checksum="AE334A00A0A7C647" modified="2017-01-18" version="1">MNSTVSRRQRLYAPTAAGLALLCSVALGAATPAQAFSGDNHEKVTRAALGPGGWHPNSLTAMADGNSGAIVANDHGEYFGIGKLHCDNADYLDPRYDSRYPRTRAQADAEIIDCVEGSVDHVKRALAAADRLVDAKGHVIAAQTSISPACAWNDQPGRAKCEVLEDLGRGWHQIEDFYAHSNWADQAAPGAVGARNPPGLGRTDLPAFFSIARYSSMNRADWVKDATRHIPHDLATGCYPDRDHTGTVSNCANRVTHDGVLNKDTKDSPRSAVGHNFDRAYDLAVKDIARQWKEFKDELQHRYPDNGRAQAMICAITHDHPDRTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ37</accession>
    <name>A0A1E7MZ37_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VII secretion protein EccC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289907.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000291.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4294"/>
    <dbReference type="EnsemblBacteria" id="ARF80351">
        <property type="protein sequence ID" value="ARF80351"/>
        <property type="gene ID" value="B6264_16815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33689">
        <property type="protein sequence ID" value="OEV33689"/>
        <property type="gene ID" value="HS99_0038345"/>
    </dbReference>
    <dbReference type="OMA" id="WEWMKWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="473"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="827"/>
            <end position="834"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1314" mass="142056" checksum="8CF3F1D2F03EEDE0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ85</accession>
    <name>A0A1E7MZ85_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7701"/>
    <dbReference type="EnsemblBacteria" id="OEV33744">
        <property type="protein sequence ID" value="OEV33744"/>
        <property type="gene ID" value="HS99_0038030"/>
    </dbReference>
    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="27209" checksum="1E6C509D42C42E2A" modified="2017-01-18" version="1">MSSTAPPRVLTVAGSDSGGGAGIQADLKAMLALGVHGMSVITAVTAQNSLGVQGYWELPAEAVRAQFRSVVDDIGVQAVKTGMLASIELVETVADLLSGVDAPVVVDPVGVSKHGDALLAAEAVATVREKLLPVATVVTPNLHEVTQLTGRTVEDESQMLAAAGALLDLGPRWVLVKGGHLEGEAADLLYGGPDEVHWYRAPRYDNRHTHGTGCTLASSIAAGLAKGESLPEAVGSAKEYITGAIAGGFALGAGIGPVDHAWRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC4</accession>
    <name>A0A1E7MZC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3776"/>
    <dbReference type="EnsemblBacteria" id="OEV33792">
        <property type="protein sequence ID" value="OEV33792"/>
        <property type="gene ID" value="HS99_0037820"/>
    </dbReference>
    <dbReference type="OMA" id="LEFARPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="26426" checksum="A620A6AF5CB37B0B" modified="2017-01-18" version="1">MNAYVGEDGVAVLEFARPHRRNAVTLAVWQALPKVLDQLAEQDGVRALLLTGAGNTFSAGADITELAEVYGDPQRADAYHAVNVAAEEALAAFPHPTLAVVHGACVGGGCQLAVACDLRFVAEDARLGITPAKLGVVYPAVPTLRLARLVGPARAKYLLFSGELVRGRDALPLGLAERVLPDAELDAAALEFARLLTRRSTQTIGAVKAALAVPAERAAEALAPWERRSREASDVHEGLAAFLDGRPPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR2</accession>
    <name>A0A1E7MZR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283093.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000311.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1849"/>
    <dbReference type="EnsemblBacteria" id="ARF77757">
        <property type="protein sequence ID" value="ARF77757"/>
        <property type="gene ID" value="B6264_01395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33915">
        <property type="protein sequence ID" value="OEV33915"/>
        <property type="gene ID" value="HS99_0010555"/>
    </dbReference>
    <dbReference type="OMA" id="MVNPTAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="10158" checksum="4A1BC87DED07E2CC" modified="2017-01-18" version="1">MTRNDGVVLYWRPLCTYCMKLRFGLLFTRLRYSRRFTRVNIWKDPDAAAFVRSVADGNETVPTATVGGRPMVNPSLRQLLDAARQYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZZ4</accession>
    <name>A0A1E7MZZ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551756.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2242"/>
    <dbReference type="EnsemblBacteria" id="ARF77861">
        <property type="protein sequence ID" value="ARF77861"/>
        <property type="gene ID" value="B6264_02015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34004">
        <property type="protein sequence ID" value="OEV34004"/>
        <property type="gene ID" value="HS99_0011170"/>
    </dbReference>
    <dbReference type="OMA" id="ERCAAGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1690" mass="180766" checksum="AB68F56CEF6CD49C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N004</accession>
    <name>A0A1E7N004_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551786.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2273"/>
    <dbReference type="EnsemblBacteria" id="ARF77884">
        <property type="protein sequence ID" value="ARF77884"/>
        <property type="gene ID" value="B6264_02160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34027">
        <property type="protein sequence ID" value="OEV34027"/>
        <property type="gene ID" value="HS99_0011310"/>
    </dbReference>
    <dbReference type="OMA" id="VCDRRMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="26982" checksum="BA9A7F6C2205F876" modified="2017-01-18" version="1">MILSHDDSGTGPAVVLLHSSVCDRRMWDPQWQALLDAGHRVVRCDFRGFGDTPLPTGPYGAAADVLALLDHLGIGTTALVGASYGGRIALTAAALRPHAVTALALLCAGRPGHEPSGTLRAFGAQEDELLEAGDIEAAVELNVRTWLGPEADEPTRDHVRRMQRHNFDVQLEATGGPEKEDVDLTRITAPTLAVSGAHDLPDFRHIAAGLPTILPNARHLELPWAGHLPNLERPAEVTTLLTDFLRDPSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N005</accession>
    <name>A0A1E7N005_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280177.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77867">
        <property type="protein sequence ID" value="ARF77867"/>
        <property type="gene ID" value="B6264_02055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34012">
        <property type="protein sequence ID" value="OEV34012"/>
        <property type="gene ID" value="HS99_0011210"/>
    </dbReference>
    <dbReference type="OMA" id="MANNHGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="37829" checksum="4D76C95A97DF657C" modified="2017-01-18" version="1">MRRAAAAVAVFVGLTAVAACGPDDPAPAPAKSAPPAAAPASSAAPSGTAAPAPTKGGAPRPDGTITVAFAGDVHFEGRTQPRLTVQSPETALGPLSRTLADADLSVLNLETAITGRGAPEPKTYTFRTTPKALSVLKDSGVDVVSMANNHAVDFGADGLVDTLAAKDSSPIPVLGVGHNAKEAYAPYVTTVRGVKVAVVAASQVEDITNQKWRAGANKPGIASALDVPALVSAVQAAKQQAPVVLVYLHWGEEGKACPTAAQTAIAKKLAAVGASAVVGTHAHTMVGSGMLGNTYVGYGFGNFLWYGTSNYAFSNETGVTTLTLAADGKVTGEAFAPATIDDKGIPEPVTGAAAEAALKRRDGLRGCAGLTPPPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N047</accession>
    <name>A0A1E7N047_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551834.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2306"/>
    <dbReference type="EnsemblBacteria" id="ARF77911">
        <property type="protein sequence ID" value="ARF77911"/>
        <property type="gene ID" value="B6264_02330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34054">
        <property type="protein sequence ID" value="OEV34054"/>
        <property type="gene ID" value="HS99_0011480"/>
    </dbReference>
    <dbReference type="OMA" id="RIWGRCS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025566">
        <property type="entry name" value="DUF4331"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14224">
        <property type="entry name" value="DUF4331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35643" checksum="EED32B840D27388C" modified="2017-01-18" version="1">MSHHLSGPNLRSPRGDARLDMTDLFAFPAADTPGRTVLILNVNPYAPTQAAEFHPDAVYRINVDNDGDHRADVAYSFTFSAPESGTGAQRVTVHRSTGAAARKHEPTGDVLFSEAPVAFGDAPDVIEANGYKLSVGLRSDPFFADLEGIVDNFTWTGKDAMADANVFGIALEAPDADLGPDPTIGIWGRVSLRQNGQLVSVDRGAHPSLTAYFNAEEVKDAYNAGEPADDWETYHEAWTVVLQHTGDYTTAAATETLKLVLPDILRYDRSRPAGYPNGRTLVDDVTSARLTMVSGGKIPTDHIGPHTDLLPAFPHLGHPHPVKWLQSEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0C6</accession>
    <name>A0A1E7N0C6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557273.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3708"/>
    <dbReference type="EnsemblBacteria" id="ARF77982">
        <property type="protein sequence ID" value="ARF77982"/>
        <property type="gene ID" value="B6264_02710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34121">
        <property type="protein sequence ID" value="OEV34121"/>
        <property type="gene ID" value="HS99_0011855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="7487" checksum="32CF0245F8542E46" modified="2017-01-18" version="1">MRSGDLTTAGAIKRGGQAVVAAFDGASLESLYFSGTFLNGSGKQSHSDNSGVSGPAAFYRSCEGASKFKIAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F0</accession>
    <name>A0A1E7N0F0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2165"/>
    <dbReference type="EnsemblBacteria" id="OEV34155">
        <property type="protein sequence ID" value="OEV34155"/>
        <property type="gene ID" value="HS99_0010800"/>
    </dbReference>
    <dbReference type="OMA" id="AEADMRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017150">
        <property type="entry name" value="Pept_M20_glutamate_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037238">
        <property type="entry name" value="Carboxypeptidase_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="160"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="38285" checksum="DC858873F4296CF2" modified="2017-01-18" version="1">MARIESPSGDAPRLDALAEELAAGFRATGATARREPGPAGDHLVIEWPGRDESLPHLLVVGHHDTVWPVGTLADWPVAEHDGRLTGPGVVDMKGGLAVLEGALALLADLEQRPHRSVRLVVVSDEEVGSPDGRRLVERQLRGAAAVLGLEPPHPDGRLKTARRGSTRVRLTVTGREAHAGNDAHDGVSAVDELVDQLVLVRGLAGQPGTELNAGRISGGSRANVVAGRAEAELGLRFSTVEAQRRTLDNLARLTALRPGARVRTEVLSSRPAWPERTGNPLLRHVRLLAAVLGQQLDGAPAGGAGDTNLPGSRGLPTLDGFGAVGAGAHARHEYIRLDQLAPRIALLAALLAVPLPRLRDRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F2</accession>
    <name>A0A1E7N0F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0011445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2299"/>
    <dbReference type="EnsemblBacteria" id="ARF82573">
        <property type="protein sequence ID" value="ARF82573"/>
        <property type="gene ID" value="B6264_02295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34170">
        <property type="protein sequence ID" value="OEV34170"/>
        <property type="gene ID" value="HS99_0011445"/>
    </dbReference>
    <dbReference type="OMA" id="FAWISEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="2">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="104"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26790" checksum="AAEFCBD10F507E28" modified="2017-01-18" version="1">MPGGRLTGEDRRLIAEGLAEGLGYTEIGRRLGRPASTVMREVTRNGGPEEYRASRAQEATRQRARRRRQDRPPTSTVPAGGDGRDPQQVQEFTEFFTVLVEQQGLPRMAARALTCLCVTDSGTLTAADLVQRLQVSPASVSQAVNVLEQQGIVRRERAPGERRERYVIDDDIWLRSALAAMRMNGALITASQRGAEILGATTPAGARFGASAEFLLLMSEALQQVMDRWRQRTDARNAERER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P2</accession>
    <name>A0A1E7N0P2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554591.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6072"/>
    <dbReference type="EnsemblBacteria" id="ARF78162">
        <property type="protein sequence ID" value="ARF78162"/>
        <property type="gene ID" value="B6264_03845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34245">
        <property type="protein sequence ID" value="OEV34245"/>
        <property type="gene ID" value="HS99_0036945"/>
    </dbReference>
    <dbReference type="OMA" id="MAYAVQW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="28908" checksum="5026559660FEA781" modified="2017-01-18" version="1">MYRFLLTRQWLITMLIGLLLIPATIKLGFWQLHRHEARVARNELIGKALTASPVPFDSLSAAPGAAVPSALTWRAVTATGQYDPAHEFVVRKRTDSNGTLGYFVVTPLKLSDGKGTVLVNRGWVPSGDGATEYPPVPAAPAGEVTLTGRLRADETTGSSGGWVKDRAGLPARQFNLINTEQQSKETGTTLLGGYLELTATNPAPADQPELIPAPDHSDIGPHMAYAIQWWLFTAMIPVGVWVLIRREAKDRAKQAAEPEVELDALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N112</accession>
    <name>A0A1E7N112_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3934"/>
    <dbReference type="EnsemblBacteria" id="OEV34380">
        <property type="protein sequence ID" value="OEV34380"/>
        <property type="gene ID" value="HS99_0036280"/>
    </dbReference>
    <dbReference type="OMA" id="PGNAQMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="46437" checksum="B8AFC602D1FBED6C" modified="2017-01-18" version="1">MSRIITTALPAHGHASPLLAISADLAARGHEVVFLGGSRFAAAAERAGVRFAALPAEADWDDRDLDASFPGRADLPPGPSRIAFDVQHVFLDPIPYQHRALLGLLEEFGADVVIADAFVQGALPLALSRPRAERPALIGVGISPSMLPSVDTAPFGPGVPPLPGEEGRARMRELREEADRRGEPLQRYAEKVFSELGVRLPEGPRGRVQVAVPDVFLQLTVPGFEYPRSDAPASYRLIGALPGNVGEDRPLPDWWDEVTDGGRPVVVVTQGTLANDDLGELVAPTVSALADRDVLVVATTARPDGPRALAELLGGSLPGNVRAAGYVPFDRLLPYADVLVSNGGYGGVQTALRYGVPLVVAGASEDKPEVAARVQWAGVGLDLRTGRPAPEAVGRAVEQVLAEGRFRERARALGAEFAEYRPFDTIAELVETLGRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N159</accession>
    <name>A0A1E7N159_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0036070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1404"/>
    <dbReference type="EnsemblBacteria" id="OEV34427">
        <property type="protein sequence ID" value="OEV34427"/>
        <property type="gene ID" value="HS99_0036070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="126"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="417"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="551" mass="56440" checksum="D30D861431B6AB98" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A7</accession>
    <name>A0A1E7N1A7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290818.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000867.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1051"/>
    <dbReference type="EnsemblBacteria" id="ARF78939">
        <property type="protein sequence ID" value="ARF78939"/>
        <property type="gene ID" value="B6264_08430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34462">
        <property type="protein sequence ID" value="OEV34462"/>
        <property type="gene ID" value="HS99_0035765"/>
    </dbReference>
    <dbReference type="OMA" id="VDPRSYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="49598" checksum="639F41FA37E9CAC8" modified="2017-01-18" version="1">MSTTERPRILIVGGGYVGLYAAMRILKKMRYGEATVTVVDPRSYMTYLPFLPEAAGGNVAPRNLVAPLRKTLKQAEVLTGSVTGIDHARKVATIQPAAGDSYELPFEYLVVATGSVSRTFPIPGLAENGIGMKTVEEAIGLRNHVMAQLDKAESTSDEEVRRKALTFVVIGGGFAGIETVAEIEDMARDASKLYKTVSRDDMRFVVVEAANRILPEMGPDLGLWTKEKLEERNIEVYIETSMDSCIDGHVMLKNGMEMDAATIVWTAGVKPNPVLANFGLPLGPRGHVDTAPTLQVQGFDYVWSAGDNAQVPDLAAGEGAWCPPNAQHACRQAVVLGDNVISGMRGFPQKEYKHKNLGAVAGLGLHKGVAILFGKYKLKGRPAWWFHRLYHGAMVPTFNRKVRVFTDWTLAMFLKREAVGLSQMENPQLPIQEVTPPTKPVEAAKPAADKELASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1C9</accession>
    <name>A0A1E7N1C9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557411.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000260.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7056"/>
    <dbReference type="EnsemblBacteria" id="OEV34484">
        <property type="protein sequence ID" value="OEV34484"/>
        <property type="gene ID" value="HS99_0035380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="38905" checksum="93D25970FC2B0060" modified="2017-01-18" version="1">MQTPTNPVEAVRHPDPYPYYARLTAERPFGWDERLQAWVAADAASVTAALSAAELRVRPPGEPVPTGLLGTAAGAVFGDLVRMTDGPDQQRLKQVVLDALGEAEPAEAGKLAAERTRQSLERAGGPGFEELMFQVPARVVAALCGLDAGLEPEAARLVGDFVQCIPAGATAEQQRAAAEAAARLRELLGPGLTGAEPTGLLAALVRAAGRRDWPRTAPLLANAVGFLSQTYDATAGLIGNSLLALREQPAGDLAALAREVARHDAPIQNTRRFAAEPWRFGAATVQPGQAVLVVLAAANRDPAANPDPHAFDPARPAPSCFTFGAGPHRCPGADLAVAITAGVLDELLAHGFEAAALPAGPSYRALANARIPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M7</accession>
    <name>A0A1E7N1M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386465.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77535">
        <property type="protein sequence ID" value="ARF77535"/>
        <property type="gene ID" value="B6264_00080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34587">
        <property type="protein sequence ID" value="OEV34587"/>
        <property type="gene ID" value="HS99_0008780"/>
    </dbReference>
    <dbReference type="OMA" id="RIMVYTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="32442" checksum="F1F94AF21AF57FE1" modified="2017-01-18" version="1">MSEGPDLAAMLRSWRARVRPEDVGSPFARGARRTPGLRREEVGWLAGVSPDYVKRLEQGRAHPSADVLRALSRALRLTDAEFTLACRLAGHAAELDGTVPQLIGPDVQRLLSRLADVPIAVFDAAWTLLEHNDLWAALHGETRRRAGRETNLVWRIFHNDPGRIRHPDPEEHRASLVADLRDVASRYPADRQLAAMIRDLRRSNTDFARLWDGSAVAHHASGRKTIDHPQVGAIELDCDVLTLHGADLRIIVFTAAPDSEAADKLRLLTVLGLQDMTSPTPGSPAHAKDRGLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N264</accession>
    <name>A0A1E7N264_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555815.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4589"/>
    <dbReference type="EnsemblBacteria" id="OEV34766">
        <property type="protein sequence ID" value="OEV34766"/>
        <property type="gene ID" value="HS99_0009815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15590" checksum="14EBC84D83EFB64B" modified="2017-01-18" version="1">MLALAFLAALAADATPARPADPNRSARSTDPIDLTVPEIRHLLSLTLPGRGPHHRAARPPRPGRPHAAAAETGTGGEQPPAVVGPPIEWLRIDAKRHTARVLQTVKLRAFNPRATEWQRMHAVAARFHLEHGHLEPPTRPSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B5</accession>
    <name>A0A1E7N2B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81811">
        <property type="protein sequence ID" value="ARF81811"/>
        <property type="gene ID" value="B6264_25540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34829">
        <property type="protein sequence ID" value="OEV34829"/>
        <property type="gene ID" value="HS99_0010185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="63" mass="6897" checksum="CD29E9EEA8342E49" modified="2017-01-18" version="1">MPATDGTVLHRRCPHPDRAELQHAAPPFVEDATDRWTGETGAQPTVEDAHPADSLDRARAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2C7</accession>
    <name>A0A1E7N2C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557763.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7624"/>
    <dbReference type="EnsemblBacteria" id="ARF81802">
        <property type="protein sequence ID" value="ARF81802"/>
        <property type="gene ID" value="B6264_25485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34837">
        <property type="protein sequence ID" value="OEV34837"/>
        <property type="gene ID" value="HS99_0010240"/>
    </dbReference>
    <dbReference type="OMA" id="YARISID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="23928" checksum="6674FCF27984E571" modified="2017-01-18" version="1">MSGASTGLRPGRRRFRARAGIAAAAVLVAVGVTLLVRQPWQPVTHLPAQACWGVLDADDLRPLAGGGNGTLTAATTTPTLQPGQSAGGAGYHCELAWHGGSAPTYLGNGPTIALHTESQLTQARALDASRGAVRPLSFGSGNTAWQAAEGYSLDLAIPCGFRDPYTGQSATGYARISIDAAGNPSFPPAPPPAEVRQADARIVLKLAKAFAQQYPCTGVTLPTDPPPVPAITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2C8</accession>
    <name>A0A1E7N2C8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7617"/>
    <dbReference type="EnsemblBacteria" id="OEV34842">
        <property type="protein sequence ID" value="OEV34842"/>
        <property type="gene ID" value="HS99_0010270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="373" mass="40049" checksum="F65CE08F797ACB73" modified="2017-01-18" version="1">MCLSALLVLLDASVVSFSYVGLAVVASGVMALGAAAAQLRLYRFGRQWTAGALCVVVATVSLLTTSLVKGTVLQRTPGWAELLGLLVLLCLSCRYGRPVPLMLSVVPLFVAVVRIEGRAPTLSDLPVLNDINGLFTLLPVGFVLLGGYLRAEDGRRRTAAENVRQAERLDLARDLHDHVAHYVTAMVVQAQAGEPTAERDPATARKLFANIERTGQEGLVAMSRMVRLLRDADGAVAEAPVTPAMTRIEDLVHQFSGTGQHAWLDIADDVDGAVWSPQLAKSVERLVQEGLTNIRKHAHTATTVHVKLGTDGDRLVVRVRDNASGQQRGRVWFRPSGFGMVGLSERVVELGGELSSGPMPEGGWELAASIPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D7</accession>
    <name>A0A1E7N2D7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557713.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000608.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7587"/>
    <dbReference type="EnsemblBacteria" id="ARF81770">
        <property type="protein sequence ID" value="ARF81770"/>
        <property type="gene ID" value="B6264_25300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34868">
        <property type="protein sequence ID" value="OEV34868"/>
        <property type="gene ID" value="HS99_0010420"/>
    </dbReference>
    <dbReference type="OMA" id="ANQEFFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20978" checksum="A72B77A4794B8516" modified="2017-01-18" version="1">MAQLDRALTIRQANEAFFWQFGRSSADLCGRTFSELVHPSVQQPLLRQFSGLIEGRRDRFATDVIAVGPGDETFTVPLTAVMVRGGLPDESSILVMMPDGRPEQGGSEVVAGRKKLLSDVDARILEGIAAGISTVPLAARLYLSRQGVEYHVTCLLRKLRVPNRAALVSRAYSMGVLKVGVWPPKVVESFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G7</accession>
    <name>A0A1E7N2G7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0009770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4596"/>
    <dbReference type="EnsemblBacteria" id="OEV34884">
        <property type="protein sequence ID" value="OEV34884"/>
        <property type="gene ID" value="HS99_0009770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin_AP" evidence="3">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin" evidence="2">
        <location>
            <begin position="172"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="40811" checksum="D467007A06596F52" modified="2017-01-18" version="1">MAGTTNAEDFSAAAEHVRNLYAGVEVTHSFVDDNGQVFDCVPIASQPALRGAFSVPPEPPDAPDAAGPRGAGQGTPIQPQLRSDRLDKFGHAMSCPPGTIAMRRVTLEEVARSGGVQNFHRKYPQGKGRHPRLSPPEAAAGTHKYAHAFQGVDNLGGHDFINVWDPNVGSEVFSLSQHWYAGGSPVQTVECGYQVYPGKYGTTQPVLFIYWTADGYQNTGCYNLDCSAFVQTNSAWALGGTISPVSVSGGAQYELEVSYYLSGGNWWLYLGGTQASNAVGYYPGSLFGSGPLATNAQDIDYGGEVVNNVAWPPMGSGAFADAGWQFAAYQRDIYYFATDNTAQSAKLTGVQTSPNCFTIAVGNAPDPWNEYFFFGGPGGTDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2M3</accession>
    <name>A0A1E7N2M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288591.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000815.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5870"/>
    <dbReference type="EnsemblBacteria" id="ARF77544">
        <property type="protein sequence ID" value="ARF77544"/>
        <property type="gene ID" value="B6264_00130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34915">
        <property type="protein sequence ID" value="OEV34915"/>
        <property type="gene ID" value="HS99_0034965"/>
    </dbReference>
    <dbReference type="OMA" id="PEGRPCH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="41822" checksum="3451083E7E581421" modified="2017-01-18" version="1">MQRDAHRRAAPDRGRTLLGPALSLIHTGQTPTRSALTRALDVTRATAGAVTAELEALGLITVDSRPAGGGRGRPSHRLAIDPEGPVVVAGQIHADGLSVTLAGLGGLLDPPVHLPLPAATDPVRMLRAVAQAGAELARSTSRRCLAAALALPNPVTEPDGTALAALHFAWPSGTPVADLYDVEVGRADHGPMAVHPLPTAIANDANLAALAEYRHGAGRGARHLLFVTSGHRGVGGALVIDGHLHTGSAGLALEVGHLTVDPQGRPCVCGNRGCLNSETDPDALFAAAGLTPEPGRPLIDQARELCWAASTDERARAAVEHVIDRLGLGLAGVANILNPDRVVLSGLHLDLLEAAPDRLRAVVAERSLWGRSGRVPIVGAELAHGALAGAAELGWGPYLADPQSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2V1</accession>
    <name>A0A1E7N2V1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552856.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4689"/>
    <dbReference type="EnsemblBacteria" id="OEV35014">
        <property type="protein sequence ID" value="OEV35014"/>
        <property type="gene ID" value="HS99_0034320"/>
    </dbReference>
    <dbReference type="OMA" id="GFARTTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20620" checksum="C1748C58C080C7E5" modified="2017-01-18" version="1">MSSPEAGPPASPTTETDRRTAVLDSALATFARFGYRRTSMEEVARAAHISRPGLYFLFSSKQALFRAAAAQALERDIAAVEHVLADAGRPLAERLVEAFDQWAGRYVGPLARDVAVLIEDNPDLLGELALTAPRRFEELITDAIAVESGQATATSRAQTMISASIGLKHQAATREFYLERLKAAVHLLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2X2</accession>
    <name>A0A1E7N2X2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552858.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4690"/>
    <dbReference type="EnsemblBacteria" id="OEV35015">
        <property type="protein sequence ID" value="OEV35015"/>
        <property type="gene ID" value="HS99_0034325"/>
    </dbReference>
    <dbReference type="OMA" id="GFEMHLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="33802" checksum="C27715A27A10E715" modified="2017-01-18" version="1">MTARAPLSTSFTASSTAQEVVRGVDLTDVRAVVTGASSGIGVETARALAAAGAQVTLAVRNTAAGDAVAASIENSTAGGRPRVMRLDLADRAAVAAFVDAWSGPLHLLVNNAGVVTGGLERTREGWELQFATNHLGHLALAVGLHRALALGARERDGARIVSVSSTAHMRSGVDFDDLHFERRGYDPQIAYARSKTANCLFAVEATRRWAGEGIVANAVNPGGVATGLQRNFTARQRQSLDEAEAAGVFTYKSVQQGAATTMVAAVAPQFAHSGGHYLDDSQEAYTVPNDADLAQHPHGVKEWALDPAIAERLWTVSTALLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N346</accession>
    <name>A0A1E7N346_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="9" type="ORF">HS99_0034240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene376"/>
    <dbReference type="EnsemblBacteria" id="ARF78921">
        <property type="protein sequence ID" value="ARF78921"/>
        <property type="gene ID" value="B6264_08330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35118">
        <property type="protein sequence ID" value="OEV35118"/>
        <property type="gene ID" value="HS99_0034240"/>
    </dbReference>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18075" checksum="26826230062B45A8" modified="2017-01-18" version="1">MTQTSENVTWLTQAGYDQLKAELDHLTGPWRIEIAQKIEAAREEGDLKENAGYHAAKEEQGKYELRIRQLTQLLERAKVGEAPADSGVVAPGMVVTVAFDGDEDDLMEFLLASREVAGADDLDVYSPQSPLGRAIDGKKIGDEATYELPNGKPAMVKIVKVVPHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N372</accession>
    <name>A0A1E7N372_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829944.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4445"/>
    <dbReference type="EnsemblBacteria" id="ARF78450">
        <property type="protein sequence ID" value="ARF78450"/>
        <property type="gene ID" value="B6264_05530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35148">
        <property type="protein sequence ID" value="OEV35148"/>
        <property type="gene ID" value="HS99_0033725"/>
    </dbReference>
    <dbReference type="OMA" id="IIEWRAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="33675" checksum="E4D619FC908823BB" modified="2017-01-18" version="1">MLFTRILKLRLLIADKGGVSTLAHPTMTPARSAEGPIHGPGDLDRFSYADRPTPPAPRWEGAESDIGRVGRKTTSSRGRGLHGQLVQQLGQMIVSGDLGADRPLVPEEIGQRFEVSRTVVRESLRVLEAKGLVSARPNVGTRVRPVGDWNLLDPDIIEWRAFGPQRDEQRRELFELRWAIEPLAARLAAGHGREDVQQRLVELVEIMGHTAAQADLSTYTRADAELHALVLQMAGNRMLEHLSGIVSCALQVSGGPAISCERPSESSVSLHARLVDALGTGDGTAGEVAMRALLTVHPEIEPSVPAPREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3A1</accession>
    <name>A0A1E7N3A1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285481.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4484"/>
    <dbReference type="EnsemblBacteria" id="ARF78419">
        <property type="protein sequence ID" value="ARF78419"/>
        <property type="gene ID" value="B6264_05340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35178">
        <property type="protein sequence ID" value="OEV35178"/>
        <property type="gene ID" value="HS99_0033915"/>
    </dbReference>
    <dbReference type="OMA" id="PWWWWPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="15976" checksum="1B5D595B7F0E78CC" modified="2017-01-18" version="1">MEGMYDERLTVPRSWWLLPVAVGLTLALILIRVGGLAALVGLVVGIAAGAVAISSYGSARIRVVQGSLVAGPARIPVDALGAAQALSPAEAAAWRGPKADPRAFMLLRSYVPTALRVEVSDPADPTPYLYLSTRSPMKLAEALEEARRGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3D1</accession>
    <name>A0A1E7N3D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NHLP bacteriocin export ABC transporter permease/ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1393"/>
    <dbReference type="EnsemblBacteria" id="ARF79256">
        <property type="protein sequence ID" value="ARF79256"/>
        <property type="gene ID" value="B6264_10305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35197">
        <property type="protein sequence ID" value="OEV35197"/>
        <property type="gene ID" value="HS99_0033275"/>
    </dbReference>
    <dbReference type="OMA" id="VRRQCGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022515">
        <property type="entry name" value="NHPM_micro_ABC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03797">
        <property type="entry name" value="NHLM_micro_ABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="775"/>
            <end position="782"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="976" mass="103356" checksum="60F4CAF78EEEA8EE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3X4</accession>
    <name>A0A1E7N3X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550592.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000493.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2379"/>
    <dbReference type="EnsemblBacteria" id="OEV35387">
        <property type="protein sequence ID" value="OEV35387"/>
        <property type="gene ID" value="HS99_0032795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30465" checksum="B51F950FDFE59A75" modified="2017-01-18" version="1">MLVLPAEVDREWTDWLARELEWGPVEVHSGVADGRTFAEALAARPALAARIADSGLPVLSWGRTAAQGEGPELAAVRRYESKAAAHGLFAALAAEHPGIVVPAQERPESRRRAARRLTVRAARGLTTVLKSPHGVGGYGTVVVEPAELFAAGGGSALLRRLVRSDTMPRHGELLLEEYVAPGPAARLRDLTYDAVVGPDGAVHPVGAGAMEVAGTRYQGVTVGPGAVPRAAAETARRFALAVGERLAADGYRGWFDVDFVTDRPTVSRFPGVGSTSTTAASRTAGWARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Z3</accession>
    <name>A0A1E7N3Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2385"/>
    <dbReference type="EnsemblBacteria" id="OEV35384">
        <property type="protein sequence ID" value="OEV35384"/>
        <property type="gene ID" value="HS99_0032770"/>
    </dbReference>
    <dbReference type="OMA" id="MRLPQTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="32760" checksum="949C4F1E2B2D59DB" modified="2017-01-18" version="1">MTDMTSDTTVTTVTASASGTWKLGDRTVHRIGFGAMRLPQTGPALMPDAVPRDREQALRVLRRAVELGVNHIDTAAFYFSPLRSANELINRALAPYADDLVIATKVGPARGPDGQWTEHARTPAGLRAQVEENLRQLGRDHLDLVNLRILGTDSIAERFGALAELQQAGLIRRLGLSNIHPHQLAEARTIAPVTCVQNPYGIGASAAQDELLRLCGEQGIAFVPFYAIAGDGRQGGAGATEPAQVQAVAEARGISTAQVRLAWTLHRGPHVLAIPGTGDVAHLEDNIAAGAVRLTAEELALLDQAHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4A6</accession>
    <name>A0A1E7N4A6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5487"/>
    <dbReference type="EnsemblBacteria" id="OEV35527">
        <property type="protein sequence ID" value="OEV35527"/>
        <property type="gene ID" value="HS99_0032035"/>
    </dbReference>
    <dbReference type="OMA" id="DHERAGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="17162" checksum="5FF39D41099ECEFB" modified="2017-01-18" version="1">MSAEQMSRLDRVDRSILRLLQQDGRASIRSVAERVHVSRANAYARISRMVEDGIIRGFTARVDHERAGQGASAYITLKIVQNSWRTVREQLLELPGVAHIALVGGDFDVLLLVHTADNHALRELVLNRIQSIPQVLGTRTMLVFEETDQVPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C2</accession>
    <name>A0A1E7N4C2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000563.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2151"/>
    <dbReference type="EnsemblBacteria" id="ARF79427">
        <property type="protein sequence ID" value="ARF79427"/>
        <property type="gene ID" value="B6264_11290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35538">
        <property type="protein sequence ID" value="OEV35538"/>
        <property type="gene ID" value="HS99_0032100"/>
    </dbReference>
    <dbReference type="OMA" id="YIRRIVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043857">
        <property type="entry name" value="DUF5819"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19136">
        <property type="entry name" value="DUF5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="24079" checksum="3F0241DD319B8FBE" modified="2017-01-18" version="1">MTGTTDRAAPGRVWSGPAQLVLGLAAAVLVSGTGLFLAAVFLHVAPDNVLSRQYRDEVDGVVYPEFEQNWKLFAPNPLQQNVSLDARVRTVADGGATRTRDWIGLTARDIAAIRGNPAPSHVDQNLLRRAWDFYDGSHDPQDEKPTSSRGRLAEQYLKRIALQRIGREVGGERVLEIEFRVTTATVPPPSWSGETGPSAPKVRELPWWPVGDEDYRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4D7</accession>
    <name>A0A1E7N4D7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552732.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5482"/>
    <dbReference type="EnsemblBacteria" id="ARF82763">
        <property type="protein sequence ID" value="ARF82763"/>
        <property type="gene ID" value="B6264_11250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35556">
        <property type="protein sequence ID" value="OEV35556"/>
        <property type="gene ID" value="HS99_0032060"/>
    </dbReference>
    <dbReference type="OMA" id="CAHEACI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20136" checksum="CE5CCC2F872A252B" modified="2017-01-18" version="1">MPDPRDHRPLIGEPLALDLLNTRWAGTPVNDALTGVEQYGIWLSSNGLSERCTADEAGLEAIRQAREAIELAAQDAREQGELGAPARDGLDAVLAHGRIRRTAGPGGAEDRVEADRPEWLAPWLAADDFLTLLGQGAHRVKQCAHEACILHFFDASQNGRRRWCRMAVCGNRAKAARHYVKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4E1</accession>
    <name>A0A1E7N4E1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552737.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5490"/>
    <dbReference type="EnsemblBacteria" id="OEV35555">
        <property type="protein sequence ID" value="OEV35555"/>
        <property type="gene ID" value="HS99_0032020"/>
    </dbReference>
    <dbReference type="OMA" id="HPCIMAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="45619" checksum="6DCFC1783F75FF33" modified="2017-01-18" version="1">MPVVREFRLPDLGEGLTGAEVVRWMVEVGEVIAVDQPVVEVETAKAVVEVPCPYGGVVTARYGAEGEEIAVGAPLVTVAVASAGGGAADTAASSPASSASSAEVERPLVGYGVVESRGARRRRVGAAAAPASAPAPVAVAAPVAPAEPVEPVAPAAPVVVPVISPLVRRLAREQGVDLTALTGSGPDGLIMRADVERAVAAKVAAPAPAAPVAVAQDGVVPLRGLRKAVAEKLSRSHREIPAATCWVDADATELMSLRRQLNSTPGPKVSVLALLARICTVALARFPELNSSVTEDGSGIVRHSAVHLGFAAQGERGLVVPVVRDAQAHSTEQLGEELGRLTESARSGSLTPAELTGGTFTLNNYGVFGVDGSTPILNHPEAAMLGVGRIVAKPWVHDGELAVREVTQLSFTFDHRVCDGGTAGGFLRFVADCVEQPGMLLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4L4</accession>
    <name>A0A1E7N4L4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="9" type="ORF">HS99_0006655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280437.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5390"/>
    <dbReference type="EnsemblBacteria" id="ARF80787">
        <property type="protein sequence ID" value="ARF80787"/>
        <property type="gene ID" value="B6264_19420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35594">
        <property type="protein sequence ID" value="OEV35594"/>
        <property type="gene ID" value="HS99_0006655"/>
    </dbReference>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="22782" checksum="899D372F6442FFF3" modified="2017-01-18" version="1">MGKNVVVLDYGSGNLRSAQRALERTGANVTVSSDYDTAMAADGLLVPGVGAFEACMRGLKSVRGDWIIGRRLAGGRPVMGICVGMQILFEKGVEHGVETPGCDEWPGTVEPLDAPVVPHMGWNTVDVPEGSRMFAGLDPETRFYFVHSYGVRHWELETHSARINPPLVTWATHGQPFVAAVENGPLWATQFHPEKSGDAGAALLTNWVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X4</accession>
    <name>A0A1E7N4X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene802"/>
    <dbReference type="EnsemblBacteria" id="ARF80954">
        <property type="protein sequence ID" value="ARF80954"/>
        <property type="gene ID" value="B6264_20405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35747">
        <property type="protein sequence ID" value="OEV35747"/>
        <property type="gene ID" value="HS99_0007630"/>
    </dbReference>
    <dbReference type="OMA" id="SGLCSFH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="19083" checksum="EAA218B5E56A1886" modified="2017-01-18" version="1">MTEDIVRTGALPEHAVRTALLELLAERRTLTSTEAAARLGYSSGLCSFHLRQLARYGVIEEAPATDGRARPWRLAQAQPPTTGDGFGELARGLEDESYRHWLARRAEAPAEWQQDEAFSTVVHLTPEELTAVADAVRQLLTRYRGRDTDPRTRPAGARPVAAVARLFPLLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N566</accession>
    <name>A0A1E7N566_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HS99_0008220</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286102.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3355"/>
    <dbReference type="EnsemblBacteria" id="ARF81051">
        <property type="protein sequence ID" value="ARF81051"/>
        <property type="gene ID" value="B6264_21000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35840">
        <property type="protein sequence ID" value="OEV35840"/>
        <property type="gene ID" value="HS99_0008220"/>
    </dbReference>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02069">
        <property type="entry name" value="methionine_synthase_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033706">
        <property type="entry name" value="Met_synthase_B12-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="743"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1165"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="746"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="930"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OEV35840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1169" mass="127326" checksum="BA85E221FE17AB9E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5D2</accession>
    <name>A0A1E7N5D2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS domain-containing sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0008560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286231.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7280"/>
    <dbReference type="EnsemblBacteria" id="ARF81111">
        <property type="protein sequence ID" value="ARF81111"/>
        <property type="gene ID" value="B6264_21335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35900">
        <property type="protein sequence ID" value="OEV35900"/>
        <property type="gene ID" value="HS99_0008560"/>
    </dbReference>
    <dbReference type="OMA" id="TRFWRGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="40089" checksum="A6E766E3F064AAB0" modified="2017-01-18" version="1">MVGSGPELDPDDLPDGLVVADARGRVVCFNRAAARLTGVLPEAALGSALEDVLPLEDLDGRRWWQLTDPYGGLAIRTRQPERNLLLPGGREVLVSARYVRAEPLGPVDRLVIALRGTEARRRTERSHAELIATVAHELRSPLTSVKGFTATLLAKWERFTDGQKRLMLETVDADADRVTRLIAELLDISRIDAGRLELRKQVVDLAAAVRRHVERKVATGIAEERFDIRVTEPLTVLWADPDKVDQVLANLLENAVRHGEGTVTIEVAPAKEVVEAPVWERSGTPPRIVEGTAVTVSDEGSGIPEESMPRVFTRFWRGSKRGGTGLGLYIVKGIVEAHGGSIRVDRAPGGGARFRFVLPAGVPDFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P8</accession>
    <name>A0A1E7N5P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287491.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene511"/>
    <dbReference type="EnsemblBacteria" id="ARF78809">
        <property type="protein sequence ID" value="ARF78809"/>
        <property type="gene ID" value="B6264_07675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36026">
        <property type="protein sequence ID" value="OEV36026"/>
        <property type="gene ID" value="HS99_0031455"/>
    </dbReference>
    <dbReference type="OMA" id="FVYQSHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26902" checksum="EE472FC46D2FB6FD" modified="2017-01-18" version="1">MSHTDQSRQAPVLHLEDVTRVHGQGAAEVQALRGVDLKVHPGEFVAVMGPSGSGKSTLLTLAGGLDTPTTGQVLVEGVALGTLSRKKLAQVRRRSIGYVFQDYNLIPALTAAENISLPRELDGLSARAARREALAALEELGIPELADRFPDDMSGGQQQRVAIARALIGERRLVLADEPTGALDSTTGEAVLAVLRARCDAGAAAMMVTHEARHAAWADRVVFLRDGRMVDESVSQDAASLLVSAAANSRKVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Q6</accession>
    <name>A0A1E7N5Q6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ORF">HS99_0031350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287444.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000723.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene488"/>
    <dbReference type="EnsemblBacteria" id="ARF78830">
        <property type="protein sequence ID" value="ARF78830"/>
        <property type="gene ID" value="B6264_07785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36008">
        <property type="protein sequence ID" value="OEV36008"/>
        <property type="gene ID" value="HS99_0031350"/>
    </dbReference>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="373" mass="41485" checksum="C6FBD8849922E4DA" modified="2017-01-18" version="1">MSMINSLRAAVRTNRRRGAAGAYDAVPEGSGSAVVDCAVYQHGRRNGETCSPREAARRVKAAHQLPDSSGSFSWIGLHEPTGAEFEGIAQRFGLHPLAVEDAVHAHQRPKVERYDDVLFAVFKTIRYVEHDQLTPTSEVVETGELMVFAGRDFVITVRHGGHGSLQELRHRLEADADEAGLLAKGPAAVLHAIADHVVDNYLLVAERLQNDVDEIEYGVFSAKGARSADVGRVYQLKREVLEFKRAVAPLLRPMQQLSEPLQRLVDPDMQKYFRDVADHLARVTEQVHGFDELLNSLLQANLAQVSVAQNEDMRKITAWAAIFAVPTMITGVYGMNFDYMPELHHAYGYPMVLGAITLICIGMYRGFRRNGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5T6</accession>
    <name>A0A1E7N5T6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386869.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000547.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6320"/>
    <dbReference type="EnsemblBacteria" id="ARF82686">
        <property type="protein sequence ID" value="ARF82686"/>
        <property type="gene ID" value="B6264_07605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36066">
        <property type="protein sequence ID" value="OEV36066"/>
        <property type="gene ID" value="HS99_0031520"/>
    </dbReference>
    <dbReference type="OMA" id="VRWVSNQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="21385" checksum="DB86F4FF547E1B2C" modified="2017-01-18" version="1">MPPEGHDRSRVEVRRSARRSRTVSAYREGDRTVVLIPARMSHAEEQRWVTQMLEKLAAQERRRILGDDALMGRARELSAAYLGGRAQPVQVRWVTNQNSRWGSCTPSEGTIRLSHRLQGMPEYVLDYVLLHELAHLLVPDHGPAFWALLEAYPRTERARGYLEGVVSAARLPHIPGARHGAPSPDPAASCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z1</accession>
    <name>A0A1E7N5Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzC/PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280978.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000609.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4975"/>
    <dbReference type="EnsemblBacteria" id="ARF80043">
        <property type="protein sequence ID" value="ARF80043"/>
        <property type="gene ID" value="B6264_14975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36098">
        <property type="protein sequence ID" value="OEV36098"/>
        <property type="gene ID" value="HS99_0030995"/>
    </dbReference>
    <dbReference type="OMA" id="YAWAWED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22785" checksum="84AD748AC1F32C01" modified="2017-01-18" version="1">MTDYEVLRVFCGPDGQHGNELGVVRDGAAVPGRAARQELARELGFSETVFVDDPERGEIDIYTPSVRLPFAGHPCVGTAWLLGVGQLVTAAGVVAVRHERGLTRIEARPEWAPGRTLRQYGSVAEVEALEVPPPGEWIYAWAWQDETAGTVRARAFPGRGDGIDEDEATGAAALLLAAHLGRALTITQGRGSQLMAGPRPGGLVEVGGRVVSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N687</accession>
    <name>A0A1E7N687_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0030540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000207.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8092"/>
    <dbReference type="EnsemblBacteria" id="ARF79800">
        <property type="protein sequence ID" value="ARF79800"/>
        <property type="gene ID" value="B6264_13590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36188">
        <property type="protein sequence ID" value="OEV36188"/>
        <property type="gene ID" value="HS99_0030540"/>
    </dbReference>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42793" checksum="9164D7D8AEE18845" modified="2017-01-18" version="1">MPEAERDTPCGLHLFWDEAVTAYDFGPGHPMDPTRLALTMRLVEALGLDTGPGVTVRSAPPAGESTLHLVHTREYVEAVKHAAAHPEQSDPRHGLGTDDNWSFPAVHSASALIAGQSVAAAEAVWRGDTPHAVNFAGGLHHAMPGKASGFCVYNDPALAIARLLELGAERIAYVDVDVHHGDGVQEAFWNDPRVLTVSLHEHPATLFPQTGWPSETGGPDAPGSAANLPLPAGTGDAGWLRAFHALVPELLEAFRPQVLVTQHGADTHLEDPLAHLAVTVDAQRLIAEELHELAHRYADGRWVATGGGGYAVVDVVPRTWTHLVATAAGRPVDPATETPEAWRAEVYRRTRRPAPLRMTDGARPAWRDFESGYDPADRLDQAILAGRRAVFPHHGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H2</accession>
    <name>A0A1E7N6H2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2611"/>
    <dbReference type="EnsemblBacteria" id="OEV36306">
        <property type="protein sequence ID" value="OEV36306"/>
        <property type="gene ID" value="HS99_0030330"/>
    </dbReference>
    <dbReference type="OMA" id="PWGDYVS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="130"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="432" mass="45265" checksum="891BD0C912263A72" modified="2017-01-18" version="1">MTVQPSDTRPQSPAAAPLPVLLVVYGRGSATPRGILGAARRLCTVVFLGDLGDPKAAADLAGLPKSATVVDTAGLTEEQLVERAAGFGASGVITFSDHLLRSAAAVAERCGLPFHDRATVEVLVDKFQQRAALAAAGVQSTVCRTVRSAADLAPALAATGLPAVLKPRSGAGSVDTCLVRSSDELADRYAEFTTDATTPAVFVLEEYLVSDPTVVGEFWGDYVSIESAVKDGEIHTVAVTGKLPLAHPFRETGYFTPALLPDGLAEQVVALERSALRALGIREGVTHTEIKFTPDGPRLIEVNGRLGGHVSDVLKRSAGTDLLLLALRLALGDFTPPAPVLALGAACPAVAFQYFLSPPADGLAPGGGELIDDLQAVPGVDLVDARIDPTWRANWRAGTEWLIGTVYGSAAGYAELRTTVEGIHRRMDTFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J7</accession>
    <name>A0A1E7N6J7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C4-dicarboxylate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000112.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2666"/>
    <dbReference type="EnsemblBacteria" id="OEV36312">
        <property type="protein sequence ID" value="OEV36312"/>
        <property type="gene ID" value="HS99_0030060"/>
    </dbReference>
    <dbReference type="OMA" id="QPDYPRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198813" evidence="2">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="31012" checksum="6AAB4E1EAD3AD89A" modified="2017-01-18" version="1">MARRLAHPLLLLGVLCTAVATLRFHWAPDQVSPLALIAVIGYLALLERLIPYRTDWHPSGRELRWYSVYFLLSMVGGGLAQGLVTALVELLGPARPALPFALEVPLALLLGSLGDYLVHRWSHRNRWLWRLHGVHHVPDKVNVANNGVNHFLDVLFAQSVVQLLLALIGFSADSVFVVGIFVMAQGYFVHANIDVRIGLLGHVLAGPELHRLHHSTDLAEAGHYASDLSLWDHAFGSFTWRPGRTPETVGLTDPAAFPATGELGATLLHPWRRTRTTEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L6</accession>
    <name>A0A1E7N6L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36318">
        <property type="protein sequence ID" value="OEV36318"/>
        <property type="gene ID" value="HS99_0029550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="6249" checksum="4845CA2C54F7DC5F" modified="2017-01-18" version="1">MGAYGPGTGGAAVGASAGAAFGEVAAGACAGVVGAAVAAPGAPGGAVGAGETGETGETGETGVDTGAGVGRSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N8</accession>
    <name>A0A1E7N6N8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0031135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5004"/>
    <dbReference type="EnsemblBacteria" id="ARF80069">
        <property type="protein sequence ID" value="ARF80069"/>
        <property type="gene ID" value="B6264_15115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36123">
        <property type="protein sequence ID" value="OEV36123"/>
        <property type="gene ID" value="HS99_0031135"/>
    </dbReference>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="525" mass="53977" checksum="CDB1404FA85C5BC1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R8</accession>
    <name>A0A1E7N6R8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4969"/>
    <dbReference type="EnsemblBacteria" id="OEV36153">
        <property type="protein sequence ID" value="OEV36153"/>
        <property type="gene ID" value="HS99_0030965"/>
    </dbReference>
    <dbReference type="OMA" id="FLRTYMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="34238" checksum="E9597224393CE99D" modified="2017-01-18" version="1">MPDGTEQRYRAAELGPDEPAVLLAPRLAQFAAVARLEHVTQAAALLGVPQPTLSRAVARLEGELGVDLLARQGRTVRLTRAGRLLLASVERALAELERGAEAARAEADPAAGRVAFGFLHTMGPDAVPALLRGFRAAHPQVRFQLVQDYGTAMLERLRAGELDLCLVAPLPDDPAFTARPLDEQRLHLVVPADHRLAGRRRIRLAEVAEEPFVGLEQGYGLRMITDGFCARAGFVPRLAFEGEETETLRGLVAAGLGVALLPPALVPRPGVVELEVTAPRTRRAIGLAWATGRPLTPPVAAFRDFVLSRRGRLLHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K5</accession>
    <name>A0A1E7N7K5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0028400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2485"/>
    <dbReference type="EnsemblBacteria" id="ARF81515">
        <property type="protein sequence ID" value="ARF81515"/>
        <property type="gene ID" value="B6264_23685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36687">
        <property type="protein sequence ID" value="OEV36687"/>
        <property type="gene ID" value="HS99_0028400"/>
    </dbReference>
    <dbReference type="OMA" id="IYYDPML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="644" mass="67755" checksum="069425BF0FC9F161" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N4</accession>
    <name>A0A1E7N7N4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Virginiamycin B lyase</fullName>
            <ecNumber evidence="1 2">4.2.99.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 2">Streptogramin B lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">vgb</name>
        <name evidence="3" type="ORF">HS99_0028505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Vgb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550668.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2464"/>
    <dbReference type="EnsemblBacteria" id="ARF81530">
        <property type="protein sequence ID" value="ARF81530"/>
        <property type="gene ID" value="B6264_23790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36700">
        <property type="protein sequence ID" value="OEV36700"/>
        <property type="gene ID" value="HS99_0028505"/>
    </dbReference>
    <dbReference type="OMA" id="ALWFTEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01282">
        <property type="entry name" value="VirginiamycinB_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011217">
        <property type="entry name" value="Streptogrm_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026412">
        <property type="entry name" value="Streptogrm_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="1 2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="29619" checksum="EF0F78A83BCFF916" modified="2017-01-18" version="1">MRVELFEVAGAGDGPYGIAVGPDGGVWFTLVHAGEIGRLGADGAVERLGLGAPGCGPSVITVGPDGALWFSRMRDHRIGRITVDGKISSYGLPTGDAGPYGIAAGPDGALWFTELNAHRVGRITVDGEVAEYPLPQAGAFPSVITAGADGALWCTLNQADAIARVSVHGEVTVHRLPTGGTAPVGITAGADGALWYVGIGGGLVGRITVDGQVTEYPLADRAAKPHAIAAGPDGRLWFTEWGAGRIGVLTPDGRLDGHPIPGPGAEPHGIAVGPDGAVYAALERGQIARLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N852</accession>
    <name>A0A1E7N852_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386830.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6458"/>
    <dbReference type="EnsemblBacteria" id="ARF78678">
        <property type="protein sequence ID" value="ARF78678"/>
        <property type="gene ID" value="B6264_06900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36875">
        <property type="protein sequence ID" value="OEV36875"/>
        <property type="gene ID" value="HS99_0026785"/>
    </dbReference>
    <dbReference type="OMA" id="CWNAKDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11896" checksum="898CB786F6A79DB6" modified="2017-01-18" version="1">MPRRNRIKSAASRESAEPAAAPLGGSLRRTENYQGDDWVVQTVAGTSGRFYRCPGCDQEIPPGMGHVVAWPMHGGGVDDRRHWHRACWGARERRASNVLRGRGAPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N864</accession>
    <name>A0A1E7N864_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551372.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6466"/>
    <dbReference type="EnsemblBacteria" id="ARF78671">
        <property type="protein sequence ID" value="ARF78671"/>
        <property type="gene ID" value="B6264_06865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36882">
        <property type="protein sequence ID" value="OEV36882"/>
        <property type="gene ID" value="HS99_0026820"/>
    </dbReference>
    <dbReference type="OMA" id="TFLHPKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16627" checksum="FFBCB7880CC8FFA4" modified="2017-01-18" version="1">MLTRIDHIGIACRDLDKTVEFYRATYGFEVFHSEVNEEQGVREAMLRINGTDDGGASYLQLLEPTRPDSTVAKWLEKNGEGVHHIAFGTADVDGDSEAIRGKGVRVLYDEPRIGSMGSRITFLHPKDCGGVLTELVTSAQPAGHEGHGAHGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K7</accession>
    <name>A0A1E7N8K7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7477"/>
    <dbReference type="EnsemblBacteria" id="ARF81700">
        <property type="protein sequence ID" value="ARF81700"/>
        <property type="gene ID" value="B6264_24865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37027">
        <property type="protein sequence ID" value="OEV37027"/>
        <property type="gene ID" value="HS99_0004135"/>
    </dbReference>
    <dbReference type="OMA" id="DGVGHTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="35600" checksum="0C6F5E30BD0755F5" modified="2017-01-18" version="1">MDETTTPQNKLTHSRPDAAPNVPRRRRVRTRRWRITALAAGVLALLLAGNTVSVLTETAGASGDQIVRIPGGDLHVVQDGPPDAPTVVLLHGLGGSTAWWNPVLPALRDLHVVRVDLLGHGRSAKPASGYGMAEQARRVAAALDRLGVHRATVVGHSTGGAVATALAEQRRDLVGAIALVDTGPRLDAYIGDSFAAHLMSTPVVAELIWRLRTDGTIRAALSSAFTRDVKIPDRIVADVRGMTYRSLTATDAASSAYLKERPIPDRLAGLGLPTLVVFGSQDHRWRPSSAQDYRQVPHARIEILDGVGHTPMLEDPDTTGTLLHGFAIETAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U4</accession>
    <name>A0A1E7N8U4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551373.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6467"/>
    <dbReference type="EnsemblBacteria" id="ARF78670">
        <property type="protein sequence ID" value="ARF78670"/>
        <property type="gene ID" value="B6264_06860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36883">
        <property type="protein sequence ID" value="OEV36883"/>
        <property type="gene ID" value="HS99_0026825"/>
    </dbReference>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="397" mass="40704" checksum="4AB24884300675FD" modified="2017-01-18" version="1">MTNNTSVIVAGARTPMGRLLGSLKGFSGADLGGFAIKGALERAGITGDQVQYVIMGQVLQAGAGQIPARQAAVKAGIPMNVPALTVNKVCLSGLDAIALADQLIRAGEFDIVVAGGQESMTNAPHLLPKSREGYKYGAVEVLDAMAYDGLTDAYENIPMGESTEKHNTRLGIPREVQDEIAAASHQRAAKAQADGVFDAEIVPVAIPQRKGEPVLFSQDEGIRADTTVEGLAKLRPAFTKDGTITAGTSSQISDGAAAVVVMSKAKAEELGLTWIAEIGAHGNVAGPDNSLQSQPSNAIRHALSKEGLEVSDLDLIEINEAFAAVAHQSMKDLGVSSNIVNVNGGAIALGHPIGMSGARVVLTLALELQRRGGGVGAAALCGGGGQGDALIVRVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W2</accession>
    <name>A0A1E7N8W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556073.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7410"/>
    <dbReference type="EnsemblBacteria" id="ARF81644">
        <property type="protein sequence ID" value="ARF81644"/>
        <property type="gene ID" value="B6264_24505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37084">
        <property type="protein sequence ID" value="OEV37084"/>
        <property type="gene ID" value="HS99_0004485"/>
    </dbReference>
    <dbReference type="OMA" id="SPKAFLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="43787" checksum="1FBEA856F4BBD3DB" modified="2017-01-18" version="1">MAEIVLDGITKRYPDGALAVRDVNLTIADGEFVILVGPSGCGKSTTLNMIAGLEDITDGTLRIAGQVVNDRAPKDRDIAMVFQSYALYPHMSVRDNMGFALRLAKADKATIAAKVEEAARILDLTQHLDRKPANLSGGQRQRVAMGRAIVREPKAFLMDEPLSNLDAKLRVQMRTQIAALQRRLGTTTVYVTHDQVEAMTLGDRVVVMRAGVVQQVGSPQHLYDEPVNLFVAGFIGSPGMNFLGAALEQNTLHTSLGALPLDDRTRRALERADAPRELIVGIRPENFEDAALTEHGGGVTCTVTVEVRESVGSDVYVHFTQGGGPAPTAGLTQLTQLDELDQLAELAADSGRADTGMQEQHVVARLAPATRATEGGPLDLRIDTARIHVFDPRSGANLTHPERPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N994</accession>
    <name>A0A1E7N994_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic synthesis protein MbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555172.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1300"/>
    <dbReference type="EnsemblBacteria" id="OEV37266">
        <property type="protein sequence ID" value="OEV37266"/>
        <property type="gene ID" value="HS99_0005575"/>
    </dbReference>
    <dbReference type="OMA" id="ACLAHIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8112" checksum="37E8CF1E2FD0C127" modified="2017-01-18" version="1">MDGEAQSYVVVLNDEEQYSIWPADRDLPLGWRGADVSGSKAECLAHIGEVWTDMRPLSLRQAVEQAGAAAHSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9D1</accession>
    <name>A0A1E7N9D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555091.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1256"/>
    <dbReference type="EnsemblBacteria" id="OEV37302">
        <property type="protein sequence ID" value="OEV37302"/>
        <property type="gene ID" value="HS99_0005795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="14413" checksum="8E91BDD30FC56D58" modified="2017-01-18" version="1">MIAGGFAVMVAGFALLTVVGAHSQLSVVLVAASLYASGGVGLMSQVSEVVMAAAPTERAGTPSALLESGTELGGALGMAVLGSVGTALYRSRIGGQLPADLPATARGAVRDPPGGTEGVLAQLPEAVRGPVLAAVREAFCGGMRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K0</accession>
    <name>A0A1E7N9K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82482">
        <property type="protein sequence ID" value="ARF82482"/>
        <property type="gene ID" value="B6264_29670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37367">
        <property type="protein sequence ID" value="OEV37367"/>
        <property type="gene ID" value="HS99_0006195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7189" checksum="CAA3F3852C941F7E" modified="2017-01-18" version="1">MDMAPSATMTCDACGRTAPWNPRGACSLACFDQPRPTAEEQHDMIDAAPEALAYFLAIPPGTSTDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K4</accession>
    <name>A0A1E7N9K4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556389.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5407"/>
    <dbReference type="EnsemblBacteria" id="ARF82494">
        <property type="protein sequence ID" value="ARF82494"/>
        <property type="gene ID" value="B6264_29735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37380">
        <property type="protein sequence ID" value="OEV37380"/>
        <property type="gene ID" value="HS99_0006260"/>
    </dbReference>
    <dbReference type="OMA" id="HNDLSMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28822" checksum="BA1B898A2F9B2AD1" modified="2017-01-18" version="1">MAPQSIRLLLADVDGTLVTQDKVLTERAIAAVANLRQAGILFAVTSGRPPRGMSMLIEPLELSTPIAAFNGGLFARPDMSVIEQQVVPDDVTPAAIELLIAHGLSVWVYRGADWLVLDPQGPHVARESWTVRFDPTPVDSFTPVSDGVAKVVGVSDDHDVVQKAVAAASERFGDHVSVSRSQPYYADVTHPHANKGCVVRYLSGAYRIPAEEIATIGDMPNDVLMFAHSGLSIAMGNASQEVQRAARRVTTTNEDEGFANAVERFILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K8</accession>
    <name>A0A1E7N9K8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37348">
        <property type="protein sequence ID" value="OEV37348"/>
        <property type="gene ID" value="HS99_0006065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7153" checksum="2C5DB1835B129F0E" modified="2017-01-18" version="1">MRRCHFVRDILADLGADTDGADREGAEQLPASCSMDDETICGGPEPSEPPPRAAGGICADQRANQGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA68</accession>
    <name>A0A1E7NA68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737837.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1105"/>
    <dbReference type="EnsemblBacteria" id="OEV37581">
        <property type="protein sequence ID" value="OEV37581"/>
        <property type="gene ID" value="HS99_0026635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="18663" checksum="3F1A6B1E599890C2" modified="2017-01-18" version="1" fragment="single">MRQVGALTRYHLELLVRSHAWLPPFLAFALLLVVGVTAGDPLLGGLGYGAGLLVPVSAWYVRGALTAEPPASRACLVAVAGPARVHLGALLAALSAGLLLAVGEVAALWWVSGPVAGPGAQREPGVGPALLAGLVTSVVCVLLGVLAGALGNRPVLVRAPYGVLAAPAGSAGRRISSRRRVSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA86</accession>
    <name>A0A1E7NA86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286562.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1113"/>
    <dbReference type="EnsemblBacteria" id="ARF82710">
        <property type="protein sequence ID" value="ARF82710"/>
        <property type="gene ID" value="B6264_08765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37599">
        <property type="protein sequence ID" value="OEV37599"/>
        <property type="gene ID" value="HS99_0026590"/>
    </dbReference>
    <dbReference type="OMA" id="AACIPDN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="23462" checksum="DB3FB8B3ECABDA48" modified="2017-01-18" version="1">MNAGWPVELQEGEVVLRPIRARDQREWQEVSRRNRDWLRRWEATVPPGPAGQAVGPRPTYRQMVRFLRGEASAGRMLPFVVIHKGQLVGQLTVGGITWGSMCSANIGYWIDEAVAGRGIMPTAVALSVNYCFHTLGLHRIEVCIRPENGPSRRVVEKLGFRSEGIRPRYLHIDGDWRDHLVYALTAEEVPEGMLERWRALSSGRGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAQ6</accession>
    <name>A0A1E7NAQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase IS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030599454.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000735.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000141_gene3391"/>
    <dbReference type="EnsemblBacteria" id="ARF78087">
        <property type="protein sequence ID" value="ARF78087"/>
        <property type="gene ID" value="B6264_03395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37777">
        <property type="protein sequence ID" value="OEV37777"/>
        <property type="gene ID" value="HS99_0024605"/>
    </dbReference>
    <dbReference type="OMA" id="RKTITWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001598">
        <property type="entry name" value="Transposase_IS30_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01043">
        <property type="entry name" value="TRANSPOSASE_IS30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="51885" checksum="9EDE4C615BCA5D78" modified="2017-01-18" version="1">MGRPVGWTTTVTGRPAMRSPGRPPVRRDVERAFWRKIAEGLTSEDAAIACGVSGPVGSRWFRQRGGMPSIQLSPLSGRYLSFAEREEIALLKARDTGVREIARLLGRAPSTISRELRRNAATRCGQLDYRASNAQWKAELAAKRPKPAKLAEHERLRNYVQDRLAGVIHARDGRPVEGPRTQEWKGRNKPRRQDRRWATCWSPQQIANRLPVDFPDDDSMRISHEAIYQALFIQGRGALKRDLVTCLRTGRALRVPRTRSRQRAAGHVTPEVMISQRPADAEDRAIPGHWEGDLIIGTGKSAIGTLVERTTRFTMLLHLPRMEGFGVEARTKNGPALAGLGAEAVKDAIAATITTLPEQLRRSLTWDRGKELAQHAQLKIDTGMAVYFADPHSPWQRGTNENTNGLLRQYFPKGTDLSRWNADELEAVARTLNGRPRKTLGWKTPAEALNERLLLLQEAGVATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK5</accession>
    <name>A0A1E7NBK5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288501.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3031"/>
    <dbReference type="EnsemblBacteria" id="ARF79721">
        <property type="protein sequence ID" value="ARF79721"/>
        <property type="gene ID" value="B6264_13135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38067">
        <property type="protein sequence ID" value="OEV38067"/>
        <property type="gene ID" value="HS99_0022965"/>
    </dbReference>
    <dbReference type="OMA" id="TQYIQMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1054" mass="112822" checksum="5866A6227E8865B2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY4</accession>
    <name>A0A1E7NBY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene462"/>
    <dbReference type="EnsemblBacteria" id="ARF82692">
        <property type="protein sequence ID" value="ARF82692"/>
        <property type="gene ID" value="B6264_07915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38195">
        <property type="protein sequence ID" value="OEV38195"/>
        <property type="gene ID" value="HS99_0023540"/>
    </dbReference>
    <dbReference type="OMA" id="VLWIGVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="41989" checksum="A5BFBEC582F6D49B" modified="2017-01-18" version="1">MNSPGSPVETRRQLLVKVAWMLLWMTYLAYPAGDLINGGHSLVGQVLGWGCLAVFVVSYVLLVIFRSQAGMKPRACRVIVGTMIVLAVVSSFALGGAFLTMFIYASVCLAVISPPKHALRALVVMAALTAATGLLVHAGNDNISTFALSAFLSGVAMTGLQRLVETMKELREARAAVAHLAASEERLRLARDLHDLLGHSLSLITLKSELAGRFMDAGKDEAARAQVADIEQVARQSLIDVREAVTGFRRPTLPVELAAARTALSAAQVRLEAAPELVDAWPSLANEEAGALAWALREAVTNIVRHGEGATVCTVTADETWEGSGERYAVLEITDNGRGPGKSQPGNGLSGLDERLALVGGRLETGPGERGKGFRLRACVPLRTVSAPSEPPKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC00</accession>
    <name>A0A1E7NC00_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290053.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000369.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3320"/>
    <dbReference type="EnsemblBacteria" id="ARF80264">
        <property type="protein sequence ID" value="ARF80264"/>
        <property type="gene ID" value="B6264_16305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38226">
        <property type="protein sequence ID" value="OEV38226"/>
        <property type="gene ID" value="HS99_0021975"/>
    </dbReference>
    <dbReference type="OMA" id="MQEDYMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="35441" checksum="713D49FD8AE9DE72" modified="2017-01-18" version="1">MLRYLTKRLGYYAALLIAAVFLAYAISASALQPRTYFDAKVPRPSAESVEHQLTSLNLNDRTPVLVRFGHWTGGLLHGDLGRTIHDTPVSDDFGRRVWVSLRLMLLGSLLGMLLGVAAGAWSAVRQYRISDRLLTVLSFVLLSTPVFLVALFLKNGAIAAKDAAGHEVVPFTGYETPGLTGGLGAHLADWALHLLLPTVSLALGGLATYSRYQRGTMLDVLGSDYLRTAEAKGLTRRRALLKHGLRTAVIPMSTMFAYSFLGIFTGAIFTETIFGWHGMGEWLIQSINEQDVNSVVAINLFTAVVVLASGFLADTLHAALDPRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCP9</accession>
    <name>A0A1E7NCP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor sulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287815.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000165.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene351"/>
    <dbReference type="EnsemblBacteria" id="ARF82134">
        <property type="protein sequence ID" value="ARF82134"/>
        <property type="gene ID" value="B6264_27580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38469">
        <property type="protein sequence ID" value="OEV38469"/>
        <property type="gene ID" value="HS99_0021465"/>
    </dbReference>
    <dbReference type="OMA" id="YPVKGCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29155" checksum="50AC7AA119C1352F" modified="2017-01-18" version="1">MATVTELRYYPVKGCAGVRVEQAELTPAGLAHDRAFMVVDERGVFRSQRRDALLATVRPTVEPGERLALAAPGVEPVAFSVDTVGPRRKVELFGAPFLAVDQGDEAADWLSRVLGVPSRLVRVPPEHDRVTDGLNPGTSGFADSSAVHLLSRSSLDDFNERTGGAPLPVERFRPNLVVDGWPEPHTEDLLRRFTVGGAELGYTKLAIRCSVTLVDQSTGAKAGPEPLRTLARYRRAAAGGVAFGSKFSVLRPGTLRVGDELTVSDWGSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND07</accession>
    <name>A0A1E7ND07_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551520.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene683"/>
    <dbReference type="EnsemblBacteria" id="ARF77584">
        <property type="protein sequence ID" value="ARF77584"/>
        <property type="gene ID" value="B6264_00385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38561">
        <property type="protein sequence ID" value="OEV38561"/>
        <property type="gene ID" value="HS99_0019970"/>
    </dbReference>
    <dbReference type="OMA" id="PRVCMRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="18713" checksum="4992782A8CCF725E" modified="2017-01-18" version="1">MRIRAVTEDELPLLGELERAAGAPFAEIGMPEIAEDEPPAPQELARYLEHGTALVAEAPDGTVAGYLLAEPVDGALHVEQVSVHPDHARRGIGRALIEHLAEGTDAPALTLTTFADVPWNAPYYARCGFRPLADAELTPGLREIRRKEAEHGLDRWPRLCMRRDLVRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND80</accession>
    <name>A0A1E7ND80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551425.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000424.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene582"/>
    <dbReference type="EnsemblBacteria" id="ARF77667">
        <property type="protein sequence ID" value="ARF77667"/>
        <property type="gene ID" value="B6264_00895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38635">
        <property type="protein sequence ID" value="OEV38635"/>
        <property type="gene ID" value="HS99_0020480"/>
    </dbReference>
    <dbReference type="OMA" id="DEIVWDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="31775" checksum="4E1B28BE4D8B3438" modified="2017-01-18" version="1">MLSARKPAGRFAAVASLSAGLLLTSAVTATADEPPSGGAEQCFPNVICAHAGSGGTTATPNPGGNGGGSDGGPELCSYHGVQWACYDPQWGSFDSGEGCYYRELDKQPPADDSAWGTNKPSDGSIYSKVCPQTNGGQDGAQFVFVPTGQRAKSVAELKQEAKDRVHLPAPVGRVAPSGTAVVKAPVWLWAENATPPKPGNATSGGVSVTVTARLTGATWDFGDGRTKECATAGTPYDPKYGGTASPDCGYEFTVGSGTKQNGAFTATVSTHWVADVVVTGPKPEKYTISMPPQDSEPFTVKVAEVQVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL2</accession>
    <name>A0A1E7NDL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0018955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386817.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7342"/>
    <dbReference type="EnsemblBacteria" id="ARF81164">
        <property type="protein sequence ID" value="ARF81164"/>
        <property type="gene ID" value="B6264_21685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38755">
        <property type="protein sequence ID" value="OEV38755"/>
        <property type="gene ID" value="HS99_0018955"/>
    </dbReference>
    <dbReference type="OMA" id="GVMYFMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14517" checksum="2C88C6A478C1A917" modified="2017-01-18" version="1">MNLIILLLPIIAIVLMFRSQKKRQSQMQQMQTALEPGAGVRTIGGLYAQVKAVNDETVELEIAPGVITHFTKSAVAAVLDPQEYDAIINGRPEEDELSESEAEDVTDAAPAEDKPLSLTKDSAEKGDAEGGAPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE85</accession>
    <name>A0A1E7NE85_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557387.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4378"/>
    <dbReference type="EnsemblBacteria" id="ARF83240">
        <property type="protein sequence ID" value="ARF83240"/>
        <property type="gene ID" value="B6264_30335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39010">
        <property type="protein sequence ID" value="OEV39010"/>
        <property type="gene ID" value="HS99_0018065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="8597" checksum="48C1217292C39514" modified="2017-01-18" version="1">MAWSISRDTRLAELRQLHHARSATLANSVPGTFAHDGLTKECDAIYAEIKRLEASRGISPKAVLLALAVLALLVYSLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF3</accession>
    <name>A0A1E7NEF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1009"/>
    <dbReference type="EnsemblBacteria" id="OEV39052">
        <property type="protein sequence ID" value="OEV39052"/>
        <property type="gene ID" value="HS99_0018315"/>
    </dbReference>
    <dbReference type="OMA" id="NGLRYIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="137"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="35665" checksum="48040DB33EFC77AB" modified="2017-01-18" version="1">MPLLYAVAAVDGNSVPPRCDCFAHRYGNAGDHRDRVRRYDSDMTDAEWAAVRDLLPVPAWMSGRGGRPEGYCHRQLLDAIRYLVDNGVKWAALPADFPPYKRVHAFFTRWRDTGLLTEFHDRVRAAVRTAHGRDPQPTAAVIDSQSVKAAASVHSATRGYDGAKNINGRKRHLVVDTLGLLLMILVTPADAGDRATAADMLPALKAKFRYLRRIWADSGYTGDLVTWANTKLALIVEIVKRTDDLSGFRIVPRRWVAERTFGWLMRSRRLARDYETRTDSAQAMILWSMTMVMSRRLARHRRRARSVTPRPGAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL1</accession>
    <name>A0A1E7NEL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557350.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4350"/>
    <dbReference type="EnsemblBacteria" id="ARF83375">
        <property type="protein sequence ID" value="ARF83375"/>
        <property type="gene ID" value="B6264_30195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39137">
        <property type="protein sequence ID" value="OEV39137"/>
        <property type="gene ID" value="HS99_0017925"/>
    </dbReference>
    <dbReference type="OMA" id="CSRPACA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="549" mass="58081" checksum="67D7547C543CE98C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU2</accession>
    <name>A0A1E7NEU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3537"/>
    <dbReference type="EnsemblBacteria" id="OEV39220">
        <property type="protein sequence ID" value="OEV39220"/>
        <property type="gene ID" value="HS99_0000370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="29407" checksum="C30AE184D282C5CE" modified="2017-01-18" version="1">MVPRLVPPDQLVAAGALLSLRRSIGGVAAPAAAVLLIATAGAPAAYLVGLGTFLLSIALLAHVRPVPSARDAGAPPLREFAGAPDVARRPDLLGTCLADLAATVSPCPPPCSRSRPRSWPPPGRSACYNPRPRPAAWSRPPPAAGPGECTGTDGLSCSPPPWSALPTAAAAFAPDLWAALICLAVAGGSHWTGDTFRSAIWNRSVPDELRGPAAGLELLTGSAGPALGDLRAGGLAARQGIRAALRTGGLPCLGGSTVLAAALPALWRYDQRAHRAEVVPGSASAPAPEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEW3</accession>
    <name>A0A1E7NEW3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550182.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000221.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3562"/>
    <dbReference type="EnsemblBacteria" id="OEV39239">
        <property type="protein sequence ID" value="OEV39239"/>
        <property type="gene ID" value="HS99_0000495"/>
    </dbReference>
    <dbReference type="OMA" id="QAWWSGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="850"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="941" mass="97397" checksum="CD4D1E936F6900C4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF58</accession>
    <name>A0A1E7NF58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288906.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1510"/>
    <dbReference type="EnsemblBacteria" id="OEV39341">
        <property type="protein sequence ID" value="OEV39341"/>
        <property type="gene ID" value="HS99_0001110"/>
    </dbReference>
    <dbReference type="OMA" id="DHVAYLL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="16676" checksum="6A26BF6ACB02A7FD" modified="2017-01-18" version="1">MTGFDAFTGMLDYPVYVVTAAAPEPAGCLVGFAGQCSIDPARFTVWLSKANHTHAVALRAPALGVHLLPPDHRLAELFGGRTGDECDKFAATAWRRGPEGVPVLAAAPAWFVGGVLDRVDWGDHTGFLLEPRHVHAPGSATPVLSFRDVADIDAGHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFU8</accession>
    <name>A0A1E7NFU8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trehalose 6-phosphate phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481131.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6739"/>
    <dbReference type="EnsemblBacteria" id="OEV39554">
        <property type="protein sequence ID" value="OEV39554"/>
        <property type="gene ID" value="HS99_0002405"/>
    </dbReference>
    <dbReference type="OMA" id="VHMADPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="309"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="5">
        <location>
            <begin position="724"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="604"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="787" mass="89092" checksum="A1107956F73977CE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL7</accession>
    <name>A0A1E7NGL7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6701"/>
    <dbReference type="EnsemblBacteria" id="OEV39846">
        <property type="protein sequence ID" value="OEV39846"/>
        <property type="gene ID" value="HS99_0002605"/>
    </dbReference>
    <dbReference type="OMA" id="YYNDYCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_19_cat" evidence="4">
        <location>
            <begin position="36"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="109"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25461" checksum="766BEAB10A6A9BF6" modified="2017-01-18" version="1">MPTAASASTSTSASASAESKAGPTHATAADQAGFVVSKAQFGRMFPNRNQFYTYEALVGAMSAYPAFAHTGNDQVKRREAAAFLANVSHETGGLRHVVEQNTANYPTYCDAARPYGCPAGRAAYYGRGPLQLSWNFNYKAAGDALHIDLLHNPDLIQTNPQVAWKTALWYWNTQTGPGSMTAHQAIVTDAGFGQTIRSINGAVECNGRNTAEMKDRVDLYQRFAQILGTSPGTNLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGP1</accession>
    <name>A0A1E7NGP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6730"/>
    <dbReference type="EnsemblBacteria" id="OEV39842">
        <property type="protein sequence ID" value="OEV39842"/>
        <property type="gene ID" value="HS99_0002455"/>
    </dbReference>
    <dbReference type="OMA" id="WWWTQHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="29842" checksum="4C74898B77516A4E" modified="2017-01-18" version="1">MRGRTATLRDAPFPRRLVAQLVHIHVLDMSTRLAAQAFLTAVPVLFVLAAFMPQEVRNSVSESLRTVLGLRGASLDEVNHVLQTDLTQTTDTFGAVGILVTLLSATSCSRALQRLCERSWHLPHLAGRLAAWRWLAWLLVWLTALTVQGKVWSGFGVGHGLGVFLYLLTAALLWWWTQHLLLGGRVPWLPLLPGAVLTGAALTALAWGSRLYVPRSLERSVTQFGPLGLVFTLLSWLIVVFTAVTLGISTGYVVAGQGRLARLLATPEPASADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV33</accession>
    <name>A0A1E7MV33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553755.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6867"/>
    <dbReference type="EnsemblBacteria" id="OEV32292">
        <property type="protein sequence ID" value="OEV32292"/>
        <property type="gene ID" value="HS99_0016400"/>
    </dbReference>
    <dbReference type="OMA" id="DRLMGVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="33282" checksum="0A1760BC03942735" modified="2017-01-18" version="1">MEMTLVGLRVLREVAERGTFTAAAEALGYTQSAVSRQVAALEQATGARLFDRYPGGVRLTGAGRALLRNAVVALDALEAAERELRGAEETERGSVRLGFFPAAGAVIVPRALAMLRQEHPHIQVTTREGTTPSLVRALRAGTLDLAVLSSRPPHRSPDTDDPPLSVEPLLEVHLAVAVPADGRFAERGSVSVEEIAGAPWIASPGTADEPLLGVWPGLPGRPKVRHTARDWLTKLHLVAGGAGITTATPSLLPVVPPGVRFVPVEGVAEEVRHLNLVRLPGPPTAPTQALARALRRQAADLADLPDLPDIADHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL1</accession>
    <name>A0A1E7MVL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557463.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1223"/>
    <dbReference type="EnsemblBacteria" id="OEV32476">
        <property type="protein sequence ID" value="OEV32476"/>
        <property type="gene ID" value="HS99_0017500"/>
    </dbReference>
    <dbReference type="OMA" id="RYPQTTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="31165" checksum="C925F1218A530062" modified="2017-01-18" version="1">MRIAVTGAAGFCGSHLARAAARLGLDVTCHGRRPGPLGRHLPWDATEADPDFTGADLVVHCAAAVADLPPGHPDEAHQHAVNVTGTQRVLRAAAGRPLVHVSSASVYDPRTTAAALTEDHPTHTGHLNAYGRTKAAAEHHALAAGAVVLRPRAVYGPGDPHLLPPLLARARHGLLPLPGPDIPLSLTAVANLTDACLAALGLTTTPPWPPGAYNIADPAPYRRDTALRHVLAAHRRSARILHLPAPLARLAARTTLLPGLTPYTLDLLTRSVVLDLTRAHTQGWHPHHTLTDYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM7</accession>
    <name>A0A1E7MVM7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6897"/>
    <dbReference type="EnsemblBacteria" id="OEV32313">
        <property type="protein sequence ID" value="OEV32313"/>
        <property type="gene ID" value="HS99_0016535"/>
    </dbReference>
    <dbReference type="OMA" id="VCPGLMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="33122" checksum="CA10C9D80233EEF6" modified="2017-01-18" version="1">MGVLAGRTALVTGSSRGLGLLIAGELAQRGCRVMLCGRDELGLERALRQLGGLPGEVAATACDLMDPQAPEQLLAAVRERFGADVDLLVNNAGLIQVGPFSAVQEQDFRRAHELMTMAPLRLVQAVLPQMRARGSGSIVMISSIGGRIPAPHLLPYVAAKFALTGLSEGLAAELAPYGIRVTTVLPGLMRTGSHTAAEFAGQAGSEYAWFATAASIPLVSMDARRAARRIVRAVEGGRRELVLTPLAKAAVLAHGVAPATTNRLLALTARLLPSAGAAPEHGVPGVRAASRHRPGGPVHRLTTLGRRAGRAHNEPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR7</accession>
    <name>A0A1E7MVR7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6984"/>
    <dbReference type="EnsemblBacteria" id="OEV32521">
        <property type="protein sequence ID" value="OEV32521"/>
        <property type="gene ID" value="HS99_0016970"/>
    </dbReference>
    <dbReference type="OMA" id="GYGAYNV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="54"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="265"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="539" mass="54791" checksum="8F0E0C23B2C6411B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWS3</accession>
    <name>A0A1E7MWS3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554368.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000122.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene454"/>
    <dbReference type="EnsemblBacteria" id="OEV32881">
        <property type="protein sequence ID" value="OEV32881"/>
        <property type="gene ID" value="HS99_0039595"/>
    </dbReference>
    <dbReference type="OMA" id="PPAVMWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198504" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="124"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="573" mass="61313" checksum="E4A5432A277CC632" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX10</accession>
    <name>A0A1E7MX10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285620.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6093"/>
    <dbReference type="EnsemblBacteria" id="OEV32773">
        <property type="protein sequence ID" value="OEV32773"/>
        <property type="gene ID" value="HS99_0016130"/>
    </dbReference>
    <dbReference type="OMA" id="PHAWSFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="41189" checksum="CC06A35478370E69" modified="2017-01-18" version="1">MTILHISQPVDGGVARVVADLARGQREAGHRVLVACPRGGRLAEEAAAVGALVRDWSADRSPGPATAAEAWRLRRIVRAAVPDVVHLHSAKAGLAGRLAVRGAVPTVFQPHAWSFAAVDGPMAAATLRWERFATRWAHRLLCVSVQERADGVAAGVHADWAVVPNGVDVRHYAPADRRAARIALGLDLDAPLAVCVGRLCRQKGQDVLLAAWPEVLRRVPRARLALVGGGPEQQRMAETVRESAEPCRVRLVGDVPDPRPWLAAADLVVLPSRWEGMALAPLEAMAAARPVLLTDVPGARECLPQAERALSVVPSEGVGALATRMAEALSDPIECERRGARLRDHVVARHDVRTVVEQVDALYRDLLGAGPAAGRRRARVPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH5</accession>
    <name>A0A1E7MXH5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283487.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2681"/>
    <dbReference type="EnsemblBacteria" id="OEV33129">
        <property type="protein sequence ID" value="OEV33129"/>
        <property type="gene ID" value="HS99_0014870"/>
    </dbReference>
    <dbReference type="OMA" id="WLSVFNT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="31704" checksum="7333E81617AAAAE2" modified="2017-01-18" version="1">MTHRRWFTPWLLAGPAILWLAVFNLWPAVNTVILSFTNAKPIGGGRFTGLENYGRLLDDAQLADALLNSIVFMLVCLPLLTVLPLLLALLVQRRIPGITFFRTAFYTPVIASAVVVALIWGWVLDDRGLVNGLLGQSGLSRSPVPFLTDRWLLLFSAIALTVWKGLGYYMVIYLSALANVPRELHEAAAVDGAGPLSRFRHVTLPGVRPTMVLISALISVSSLRVFSELYVLSNGLGGPGGRDMSVVMLIQMYSRGFNGHLGYASALSLLLFVVTLGPMLFLLRLNRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK4</accession>
    <name>A0A1E7MXK4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2682"/>
    <dbReference type="EnsemblBacteria" id="OEV33175">
        <property type="protein sequence ID" value="OEV33175"/>
        <property type="gene ID" value="HS99_0014865"/>
    </dbReference>
    <dbReference type="OMA" id="AFMGAWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28201" checksum="8881116B529270EA" modified="2017-01-18" version="1">MLLVLVLLLVTGPFLWQLSTSLKGATEDVYSRTPSFLPDHPTIGNYGQVADAIPVWTYALNSVIVAAVCITGNVVGCTLAGFALARLRFRGAKLVLGLFLATLVLPGEVTIVSQYVLVRGLGLADNLLGVSLPGAIAMLNVLLMRTAFAAVPAELDQAALVDGAGVWQRLWHIGLPNVRGMLSVIVIFTFIGAWDDFLWPLIVLNDPQKYTLTVGLQYLDGTFSANPRLIAAGTMIAFLPIVVVFALCQRFFFKGVEEGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX7</accession>
    <name>A0A1E7MXX7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000124_gene6495"/>
    <dbReference type="EnsemblBacteria" id="OEV33286">
        <property type="protein sequence ID" value="OEV33286"/>
        <property type="gene ID" value="HS99_0038875"/>
    </dbReference>
    <dbReference type="OMA" id="DFADINH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="620"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1114" mass="119661" checksum="CFC729A2E9B4C5E3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY31</accession>
    <name>A0A1E7MY31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558037.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3408"/>
    <dbReference type="EnsemblBacteria" id="ARF80437">
        <property type="protein sequence ID" value="ARF80437"/>
        <property type="gene ID" value="B6264_17355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33336">
        <property type="protein sequence ID" value="OEV33336"/>
        <property type="gene ID" value="HS99_0012125"/>
    </dbReference>
    <dbReference type="OMA" id="EWDGWRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10569" checksum="ADCDF815C94F3C69" modified="2017-01-18" version="1">MTENHTPDLPDVDDPFVRQLLVLPDRDAADEAAEELGAAHPDLGEPEIVRDALAGEDDAEDAQWLVVLDPPANGWTPALLHVLDTLATSHEGWREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC7</accession>
    <name>A0A1E7MYC7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FmdB family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288775.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000689.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6569"/>
    <dbReference type="EnsemblBacteria" id="ARF80541">
        <property type="protein sequence ID" value="ARF80541"/>
        <property type="gene ID" value="B6264_17940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33436">
        <property type="protein sequence ID" value="OEV33436"/>
        <property type="gene ID" value="HS99_0012715"/>
    </dbReference>
    <dbReference type="OMA" id="RYEYRCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="76" mass="7402" checksum="C315222721C582F9" modified="2017-01-18" version="1">MPRYDFRCRSCGATFELSRPMAQANDPAACPQGHQDTVKLLSTVAVTGAAAGGTAGGAPQQQAPGGGGCCGGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYN8</accession>
    <name>A0A1E7MYN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class E sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282633.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5227"/>
    <dbReference type="EnsemblBacteria" id="ARF80649">
        <property type="protein sequence ID" value="ARF80649"/>
        <property type="gene ID" value="B6264_18615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33546">
        <property type="protein sequence ID" value="OEV33546"/>
        <property type="gene ID" value="HS99_0013395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="25310" checksum="106042CBEB80989B" modified="2017-01-18" version="1">MARQRGVVVRAVARWTGDGLLTLGLLVLLFAVYVLWWSNVVSDRAADRAAGRLRDSWSAAAPPAADADSPVAGLGRGDLGFLHVPAMGRDYEVLIRSGTDEATLADGVAGAYTVPYRSVPPWEGEGNFALAAHRDGHGAKFHDLDQVGPGAPVVVETRDRWYVYRVDGVLPETSPDDVGVIAPVPTGSPYRSPGRYITLTTCTPEYTSLYRLVVWGSLVREEAMTPGRVPPAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ6</accession>
    <name>A0A1E7MYQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000821.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5262"/>
    <dbReference type="EnsemblBacteria" id="ARF80680">
        <property type="protein sequence ID" value="ARF80680"/>
        <property type="gene ID" value="B6264_18785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33575">
        <property type="protein sequence ID" value="OEV33575"/>
        <property type="gene ID" value="HS99_0013565"/>
    </dbReference>
    <dbReference type="OMA" id="MDETEFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="19590" checksum="99EA92540DBF36ED" modified="2017-01-18" version="1">MDETDFWQIIDDTWEAAAGDPDEQAERLVERLVQLTPDDVIDFARLFEARFQRAYRHDLWGAAHLLLDGASEETFDYFRCWLIGQGREVFEGGLAEPDDLADLLPEFDEEEDGEAEDLGYAADEAYEQLTGLPLPDVGGRQAGRPSGTPLDFEDPDVMAKRFPKLWERYGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ9</accession>
    <name>A0A1E7MYQ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Octanoyltransferase</fullName>
            <ecNumber evidence="6 7">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="8" type="ORF">HS99_0013520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6 7">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6 7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282693.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5253"/>
    <dbReference type="EnsemblBacteria" id="ARF80672">
        <property type="protein sequence ID" value="ARF80672"/>
        <property type="gene ID" value="B6264_18740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33567">
        <property type="protein sequence ID" value="OEV33567"/>
        <property type="gene ID" value="HS99_0013520"/>
    </dbReference>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="265" mass="28672" checksum="0B49F506D71172E0" modified="2017-01-18" version="1">MSENVRFVRLGIGEHVVPYEEAWEEQQRLHALRVADEIPDTVLLLEHPPVYTMGKRTNPADLPLDGTPVVEVNRGGEITWHGPGQLVGYPIIKLPDPIDVIAYVRRLEEALIRSAADFGIETTRVEGRSGVWVLGENIPDAVVDPSEVVDIGKLTLRLGLPLGIDPRLAGPEYAPSNAGQRGGDRKLAAIGVRVARGVTMHGFALNCDPDMTYFDKIVPCGIRDAGVASLAGELGRGVPVSEALPSVERHLKDVLAELPEPALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT8</accession>
    <name>A0A1E7MYT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6622"/>
    <dbReference type="EnsemblBacteria" id="OEV33602">
        <property type="protein sequence ID" value="OEV33602"/>
        <property type="gene ID" value="HS99_0012985"/>
    </dbReference>
    <dbReference type="OMA" id="RRMNVAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19868" checksum="CD1FA0F5098D5531" modified="2017-01-18" version="1">MEFGIAEQVALYQREFPTVDPQVETIVQTLNRVSRRMGVAYDRQLTVLGITSAEWEVLKALVVSGSPYRLGPGDLAKRLGLTPAAMTHRIDRMVTEDLVTRERDESNRVRVIIELTENGRDKWLESMRMAAVFEEELLQDISSEERAALSGLLARMLRRIEESQPDALGRTADLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZE5</accession>
    <name>A0A1E7MZE5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ORF">HS99_0037430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289888.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000878.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4309"/>
    <dbReference type="EnsemblBacteria" id="ARF80336">
        <property type="protein sequence ID" value="ARF80336"/>
        <property type="gene ID" value="B6264_16740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33825">
        <property type="protein sequence ID" value="OEV33825"/>
        <property type="gene ID" value="HS99_0037430"/>
    </dbReference>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15903" checksum="DF38E056D24A59F0" modified="2017-01-18" version="1">MTDTARARKLADRIQVVVAQTLERRIKDPRLGFVTITDTRVTGDLREATVFYTVFGDETDREATAAALESAKGVIRSEVGKIGVRFTPTLTFVADALPENARNIDDLLDRAKAIDAAVRTTAAGATYAGDADPYRVPASERDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ1</accession>
    <name>A0A1E7MZJ1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290402.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4404"/>
    <dbReference type="EnsemblBacteria" id="ARF80321">
        <property type="protein sequence ID" value="ARF80321"/>
        <property type="gene ID" value="B6264_16665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33839">
        <property type="protein sequence ID" value="OEV33839"/>
        <property type="gene ID" value="HS99_0037505"/>
    </dbReference>
    <dbReference type="OMA" id="CQISETA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="521" mass="55319" checksum="3A579B688AFF7CBF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR4</accession>
    <name>A0A1E7MZR4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1860"/>
    <dbReference type="EnsemblBacteria" id="ARF77767">
        <property type="protein sequence ID" value="ARF77767"/>
        <property type="gene ID" value="B6264_01450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33924">
        <property type="protein sequence ID" value="OEV33924"/>
        <property type="gene ID" value="HS99_0010610"/>
    </dbReference>
    <dbReference type="OMA" id="RLPVKAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="582" mass="62737" checksum="2C0B825EBB56D3D8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU3</accession>
    <name>A0A1E7MZU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0010840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387334.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000826.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2173"/>
    <dbReference type="EnsemblBacteria" id="ARF77805">
        <property type="protein sequence ID" value="ARF77805"/>
        <property type="gene ID" value="B6264_01680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33952">
        <property type="protein sequence ID" value="OEV33952"/>
        <property type="gene ID" value="HS99_0010840"/>
    </dbReference>
    <dbReference type="OMA" id="GWNWRAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="PTHR30618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="519" mass="55683" checksum="2838F4C667223F83" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU4</accession>
    <name>A0A1E7MZU4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein HS99_0010765</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280351.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2158"/>
    <dbReference type="EnsemblBacteria" id="ARF77793">
        <property type="protein sequence ID" value="ARF77793"/>
        <property type="gene ID" value="B6264_01605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33941">
        <property type="protein sequence ID" value="OEV33941"/>
        <property type="gene ID" value="HS99_0010765"/>
    </dbReference>
    <dbReference type="OMA" id="ETRNQAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12888" checksum="172842230F66A985" modified="2017-01-18" version="1">MADINEYGGGQSPNADVLVVTTNDIPGFRVDHVIGEVFGLTVRSRHIGSQIGAGLKSLIGGELRGLTKTLVESRNEAMQRLVEQTKARGGNAVLMMRFDVTEAADAGTEVCAYGTAAVISPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZY8</accession>
    <name>A0A1E7MZY8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551760.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000504.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2246"/>
    <dbReference type="EnsemblBacteria" id="ARF77865">
        <property type="protein sequence ID" value="ARF77865"/>
        <property type="gene ID" value="B6264_02035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34008">
        <property type="protein sequence ID" value="OEV34008"/>
        <property type="gene ID" value="HS99_0011190"/>
    </dbReference>
    <dbReference type="OMA" id="LGCHIEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="31705" checksum="A2DDBA552F3D6CC1" modified="2017-01-18" version="1">MAAGTPIARPLGVPWIHGSPSAKHNTDPDIQAHAYDEHTVILRQNKAVNYEAPFLFLLFGAERAVLIDTGATAEAEYFPLRATVDNLMADWLARNPRDDYRLLVLHTHPHGDHIAADGQFADRPATTLIGAELPSAWPYFGFDRDAETIARVDLGGGRVLECLATPGHHEAAVTYYDSWTGFLLTGDTVYPGRLYINDWPAFSRTVERLIAFADSRPVTHVLGCHIEMTRTPGVDYPIRTTYQPDEPPLQLTVDHLHRIRAAVAELGDRPRRYPLDDLILWPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZZ6</accession>
    <name>A0A1E7MZZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280183.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000504.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2247"/>
    <dbReference type="EnsemblBacteria" id="ARF77866">
        <property type="protein sequence ID" value="ARF77866"/>
        <property type="gene ID" value="B6264_02040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34009">
        <property type="protein sequence ID" value="OEV34009"/>
        <property type="gene ID" value="HS99_0011195"/>
    </dbReference>
    <dbReference type="OMA" id="YRMREDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="20700" checksum="371E2F7180C03476" modified="2017-01-18" version="1">MNPEHYRLLEEARRSLPDGFKVELSGDVIVMQASPSSIHQLNLSIVQRQFDVHCPVGYFTSGNSDLSSPGVGAVRNPDLTYLPEDVIDLAGHNIPAELALIAVEVVSPSNPDNDWSGKVRDYPRMGFPLYLIIDPRQKSVTLFSEPNHDRYHTRTDREFGETIHIPEPFDFDLDLSRLVPYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N021</accession>
    <name>A0A1E7N021_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0011300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urea transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2271"/>
    <dbReference type="EnsemblBacteria" id="OEV34025">
        <property type="protein sequence ID" value="OEV34025"/>
        <property type="gene ID" value="HS99_0011300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="PTHR10464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="13140" checksum="51A21716B46B255E" modified="2017-01-18" version="1">MRSTAYGFGLRRDAVEAGLTGYNGCLVALGCAVLLGPGHPATVAVAVLGAVVAVVVTAALGALLEGRGLPALTAPFCLVATAAAAATAAATVLTPALGASTAPFGGHAFTWPFVLTTMLFLAAVPVIPRLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N177</accession>
    <name>A0A1E7N177_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1066"/>
    <dbReference type="EnsemblBacteria" id="OEV34448">
        <property type="protein sequence ID" value="OEV34448"/>
        <property type="gene ID" value="HS99_0035690"/>
    </dbReference>
    <dbReference type="OMA" id="ERFTGRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025968">
        <property type="entry name" value="YwqJ_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14431">
        <property type="entry name" value="YwqJ-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16543" checksum="AB71565FB330813D" modified="2017-01-18" version="1">MTTGEPAGPPVLRHHRDSLLPAVAAALSLKGGEVHTLAGAKEDRRPVLHPLVGEFLDTLPVEARERFTGRCPEAVLLSQYLTTVDGKRSKRAARKPMSLHEARKALKGARMTTLRIREEGDPAHGTHAPPCRSCAPMLEHFTVQSVAVGPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N179</accession>
    <name>A0A1E7N179_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7203"/>
    <dbReference type="EnsemblBacteria" id="OEV34434">
        <property type="protein sequence ID" value="OEV34434"/>
        <property type="gene ID" value="HS99_0035920"/>
    </dbReference>
    <dbReference type="OMA" id="YRVGPDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16113" checksum="5BAD550B1DBC3D75" modified="2017-01-18" version="1">MDEYCALFGLTRARLTALIQASSAYRGVYFAMIDGCAVEPDYVERHEVRMAVDRADDRLLGFYALIHEPAELDLMFVADEAQGLGIGRALITDMLDRARAAGITAVEVVSHPPAEGFYLQVGAELTGTRPPQPKTPWEQPELRFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G6</accession>
    <name>A0A1E7N1G6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7058"/>
    <dbReference type="EnsemblBacteria" id="OEV34524">
        <property type="protein sequence ID" value="OEV34524"/>
        <property type="gene ID" value="HS99_0035390"/>
    </dbReference>
    <dbReference type="OMA" id="FRYRFSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="128"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="42173" checksum="0DE5C3646BE8FAB1" modified="2017-01-18" version="1">MTDLSTAIRTVHWIGTGLSTGRSGLELLLEHGARVVLWGRTAAKAEQCLAARGLAGRAGARAFDTAALAAALAPGDVLVSMLPAAHHPELLRLALAHGAHFACSSYVSPELAELAATAERTVVLTEAGLDPGIDHLMAHRLVELGRTAAGEAACTADFTSYCGGLPAELNEFRYRFSWAPLGVLNALRSPARYLRDWQVRTAPRPWQATTEYPVAGEQFEVYPNRDSLPFAEQYDFPPQWRKRSFVRGTLRPAGWRAAWSEVFATVESGDDGRIAALAGELAERHPMRETDRDRVVLAVALDLSWTDGAWSGNCLLDLRGDERESAMALLVSLPLAYGITRILDGALAPGLHRAAEDARKAEQWLDFLAARGITTELRTTESTTRGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I8</accession>
    <name>A0A1E7N1I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6120"/>
    <dbReference type="EnsemblBacteria" id="ARF79321">
        <property type="protein sequence ID" value="ARF79321"/>
        <property type="gene ID" value="B6264_10675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34535">
        <property type="protein sequence ID" value="OEV34535"/>
        <property type="gene ID" value="HS99_0035155"/>
    </dbReference>
    <dbReference type="OMA" id="GESACCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="25397" checksum="3431553BBE11C7CD" modified="2017-01-18" version="1">MSTSGTALISGGSRGIGKAAALRLAAEGHPISFCYQSDQQAADLLTKELDALGVGVLAERVDVTDAAAVRAWVTRTEQELGPITVAVASAGITRDKPLLLMADEDWQAVTDTNLTGTANLCRAVAFPMVKRRGGSIITLSSVSGLYGNPGQSNYAASKAGIIALTRALAKEVGRYGVRVNAVAPGMIETDMTSVLTDAQRGEALKNIPLGRFGTADEVAESVAFLAGPQSAYFTGSVLQIDGGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1T9</accession>
    <name>A0A1E7N1T9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7194"/>
    <dbReference type="EnsemblBacteria" id="OEV34433">
        <property type="protein sequence ID" value="OEV34433"/>
        <property type="gene ID" value="HS99_0035870"/>
    </dbReference>
    <dbReference type="OMA" id="RPYAGEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15198" checksum="0AEC8958E9BD234E" modified="2017-01-18" version="1">MLAACDGSDGSLWALDRAMTEAELFGLPLYVLAVVNPAPAGYPPGMAELVQESVETLVESMADGLRRAVATVLRQRVRPYAGEMSLHVVLGNVIEVLLEASTRQHTLVVGTRGNGGFARLLLGSVSSAAVHHAACPVLVVPAPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z8</accession>
    <name>A0A1E7N1Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4642"/>
    <dbReference type="EnsemblBacteria" id="ARF81920">
        <property type="protein sequence ID" value="ARF81920"/>
        <property type="gene ID" value="B6264_26245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34718">
        <property type="protein sequence ID" value="OEV34718"/>
        <property type="gene ID" value="HS99_0009530"/>
    </dbReference>
    <dbReference type="OMA" id="PGFLVWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17689" checksum="4966795141B4D5EB" modified="2017-01-18" version="1">MSKGSPGPTPGFLVWRLANKWRVAVDRAVAPLGLTHAQYSLVASLHGMQRAGERPSQRRLADHTGLEALYVSKLARALESAGLIERTRDPRDPRAVQLALSEQGQAVTRQAIAVVQELLQQLLEPLGGLDAPRTCAFTDELRALLDAPLAPSLPNDETTQGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N237</accession>
    <name>A0A1E7N237_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555831.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4597"/>
    <dbReference type="EnsemblBacteria" id="ARF81879">
        <property type="protein sequence ID" value="ARF81879"/>
        <property type="gene ID" value="B6264_25995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34758">
        <property type="protein sequence ID" value="OEV34758"/>
        <property type="gene ID" value="HS99_0009765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="9504" checksum="536BA968C31A3F3B" modified="2017-01-18" version="1">MGPFQNFAGANTGTFVTEERQISATSPGGVFVTLEIDTPGVSSQASLDGVQFAGTEVYGKNPAIPGQKVDTYTRPLNVAPPTTDDPYWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F4</accession>
    <name>A0A1E7N2F4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557727.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000168.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7596"/>
    <dbReference type="EnsemblBacteria" id="OEV34860">
        <property type="protein sequence ID" value="OEV34860"/>
        <property type="gene ID" value="HS99_0010375"/>
    </dbReference>
    <dbReference type="OMA" id="FVPHVIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="20661" checksum="37B0FCE9FD95A050" modified="2017-01-18" version="1">MTTIAVLGNGRVGGNLATALTRAGHELTVADRAPGAAADAARAARIVINATPGAGSLERLAALREELRDKILVDVSNATTDGPDGLPAGLIYPGSSLAEQLQDALPETRVVKTLNTMLFPVMTAPATLTQAPTAFLSGDDPQAKQTVGELLTDLGWRKEWITDLGRIQTARATEAAILFVPHVIRSSGFAPFAISIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F7</accession>
    <name>A0A1E7N2F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558359.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000701.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000115_gene4544"/>
    <dbReference type="EnsemblBacteria" id="ARF83084">
        <property type="protein sequence ID" value="ARF83084"/>
        <property type="gene ID" value="B6264_26465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34879">
        <property type="protein sequence ID" value="OEV34879"/>
        <property type="gene ID" value="HS99_0009315"/>
    </dbReference>
    <dbReference type="OMA" id="MHDIKER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12510" checksum="F9545CF7A2E5349A" modified="2017-01-18" version="1">MTERPMQEPTLLLLTALADAPRHGYALLREIAAISDGRVRMRTGTLYGALDRLLGQGLIEVIGDEVVDGRARRTYALTDGGQAALATETERLRVVVAEAQRRLSTARPRLRGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L1</accession>
    <name>A0A1E7N2L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555968.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81943">
        <property type="protein sequence ID" value="ARF81943"/>
        <property type="gene ID" value="B6264_26385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34693">
        <property type="protein sequence ID" value="OEV34693"/>
        <property type="gene ID" value="HS99_0009395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="10333" checksum="31F0FF92E768A3D3" modified="2017-01-18" version="1">MSVTAFLLALGTTCRITRFITKDTLAAGFRSWIAARFGDDSRAAYLVSCGWCTSIWAATATALYATWLEGSPWFQVPTAALTLSYLAGVASRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R6</accession>
    <name>A0A1E7N2R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000328.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4554"/>
    <dbReference type="EnsemblBacteria" id="ARF78508">
        <property type="protein sequence ID" value="ARF78508"/>
        <property type="gene ID" value="B6264_05915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34988">
        <property type="protein sequence ID" value="OEV34988"/>
        <property type="gene ID" value="HS99_0034845"/>
    </dbReference>
    <dbReference type="OMA" id="GTWIVVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15222" checksum="9C511C4D4CF10542" modified="2017-01-18" version="1">MERTGLNWLTQAAPDPEDLRAQWERTGLGLTLLPAGRRWDVLAVPGRLGRPALDVLDTAPCGPVLTDSGEDHVSFLVPVGTAARWIGTGVRCAGEGTWIVVPHPGRGSRGVRWLVPPDGSGRLNDPVLLELALHEEAAGLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S9</accession>
    <name>A0A1E7N2S9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">HS99_0034680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030243502.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7670"/>
    <dbReference type="EnsemblBacteria" id="ARF78536">
        <property type="protein sequence ID" value="ARF78536"/>
        <property type="gene ID" value="B6264_06080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34994">
        <property type="protein sequence ID" value="OEV34994"/>
        <property type="gene ID" value="HS99_0034680"/>
    </dbReference>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12995" checksum="0830F28783F1F9D0" modified="2017-01-18" version="1">MSNKLAAVDAASLRTDIPAFRAGDTLKVHVRVIEGNRSRVQVFQGVVIRRHGAGVGETFTVRKVSFNVGVERTFPVHTPVVEKIEVVTRGAVRRAKLYYLRDLRGKAAKIKEKRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F6</accession>
    <name>A0A1E7N3F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385443.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1382"/>
    <dbReference type="EnsemblBacteria" id="ARF79265">
        <property type="protein sequence ID" value="ARF79265"/>
        <property type="gene ID" value="B6264_10355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35205">
        <property type="protein sequence ID" value="OEV35205"/>
        <property type="gene ID" value="HS99_0033325"/>
    </dbReference>
    <dbReference type="OMA" id="FPERALF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35454" checksum="42CAD1203643F2AA" modified="2017-01-18" version="1">MATAVGEHPVSVRGLRKSYGDWHAVQGLDLDIHQGEVFALLGPNGAGKTTTVEILEGVRQRTGGDVRVLGCDPAEDRREWRARIGVVPQTTGAYSDLTVREVVEHFAAFYPNPLPVGQVIDMVGLGKHEKKQSTDLSGGQARRLDVAVGIVGDPDLIFLDEPTTGLDPVARREAWDLVRYFSERGRTTVLTTHYLDEAEALCQRAAVIVAGRVVQCGPLAEFGGRSQTPTTVSFRIPPELAGRTLPSLPPGAEPAPVGADGVLRIGTHAPTALLAALVPWAHRAGVAELPELRVHRPTLEDVYLDLIRENVDGTDRGADTTQLISEAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C5</accession>
    <name>A0A1E7N4C5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278199.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5495"/>
    <dbReference type="EnsemblBacteria" id="ARF79411">
        <property type="protein sequence ID" value="ARF79411"/>
        <property type="gene ID" value="B6264_11185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35522">
        <property type="protein sequence ID" value="OEV35522"/>
        <property type="gene ID" value="HS99_0031995"/>
    </dbReference>
    <dbReference type="OMA" id="MSVGLYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11632" checksum="863C7D076C2CE082" modified="2017-01-18" version="1">MKMFRLDELDAERAANDGAYLRFLREPRMSAGLYALSPGDTDTQTAHDQDEIYQVISGRAELTVGAETATVGRGSVVYVPAGTPHRFHHITEELRVLVVFSPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M3</accession>
    <name>A0A1E7N4M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0006905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366834.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene945"/>
    <dbReference type="EnsemblBacteria" id="ARF80829">
        <property type="protein sequence ID" value="ARF80829"/>
        <property type="gene ID" value="B6264_19675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35635">
        <property type="protein sequence ID" value="OEV35635"/>
        <property type="gene ID" value="HS99_0006905"/>
    </dbReference>
    <dbReference type="OMA" id="TWVTGQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="738" mass="75503" checksum="842873454C335CEE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4S9</accession>
    <name>A0A1E7N4S9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551110.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene866"/>
    <dbReference type="EnsemblBacteria" id="ARF80903">
        <property type="protein sequence ID" value="ARF80903"/>
        <property type="gene ID" value="B6264_20075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35701">
        <property type="protein sequence ID" value="OEV35701"/>
        <property type="gene ID" value="HS99_0007300"/>
    </dbReference>
    <dbReference type="OMA" id="TLWLEVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="22052" checksum="FB021A580A72729D" modified="2017-01-18" version="1">MADPRPRRPARPREEVFATARAAIAEHGLAKLTMAGLGKQLQMSAGHLLYYFGTKDQLLLETLRWSEDQLGARRREALTDPTLDPWQRLDAYLRLYLPEGPGDPRWILWVEVWGRSPASDELRRGQQEIETPWQADLVTLIEQGTTTGHFTPGPATARAARLRALLDGLAVPIAIGLPDAHPPTALTHATSVATTLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T8</accession>
    <name>A0A1E7N4T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000882.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene867"/>
    <dbReference type="EnsemblBacteria" id="ARF80902">
        <property type="protein sequence ID" value="ARF80902"/>
        <property type="gene ID" value="B6264_20070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35700">
        <property type="protein sequence ID" value="OEV35700"/>
        <property type="gene ID" value="HS99_0007295"/>
    </dbReference>
    <dbReference type="OMA" id="WYSTHHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="23455" checksum="4B4C6F4BF1CB1164" modified="2017-01-18" version="1">MAEPSFLTAVRESYDTVAAAYVERVPPPAAMDPLSRAMLAGLAELVRTAGPGLVADLGCGPGRVTVHLAELGVSAFGVDLSPNMIELARHAHPNLRFTVGSMTALEMEDDELGGILAWYSTHHTPPQWLPAVFAEFHRTLAPGGYLLWGDYVGDERLQPTRGYGQPVSYESYLLPLNRMVDLLEQAGLVVTAKLEQEPGGRANRPRACLLARKPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N528</accession>
    <name>A0A1E7N528_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene734"/>
    <dbReference type="EnsemblBacteria" id="OEV35798">
        <property type="protein sequence ID" value="OEV35798"/>
        <property type="gene ID" value="HS99_0007975"/>
    </dbReference>
    <dbReference type="OMA" id="FRATYHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="26478" checksum="7C30CC7EC4FF5DE1" modified="2017-01-18" version="1">MTSFLTHRARVHDAALPPYRRHSALRTCLTEFAPYGLRATYHHLTVSARMPRILEADPDSLVRAVEELNEARALWLARAEQYAAQRRAEKRAGRREPPVTAWWDRPWPGSPDAVWYQDPFLHPPLSLPDYVRRQNALLDGAGLPGCPACGEEGPAVPVPTGHGRAELCRCCARVLVPCPCDRWHGYQPQPPVGWSQTWRRAHMTGSGEPNPHWPTLLETARVERLVAYESPHGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N531</accession>
    <name>A0A1E7N531_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550970.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene732"/>
    <dbReference type="EnsemblBacteria" id="ARF81010">
        <property type="protein sequence ID" value="ARF81010"/>
        <property type="gene ID" value="B6264_20760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35800">
        <property type="protein sequence ID" value="OEV35800"/>
        <property type="gene ID" value="HS99_0007985"/>
    </dbReference>
    <dbReference type="OMA" id="VTEWRMH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18910" checksum="DAB994BAB0136A4A" modified="2017-01-18" version="1">MNDHSRPGNDYSYPEQGASCTGDLPAGYRHLRHRARIGHGRPALDVAGGALLGWRMHRLAGVRIDAEAEEAAPGVAVRCAIGLGPLRAGAPNRVLATVNGPDRYGFTYGTRHGHLGRGEETFLVELAPDGAVWFSVTAFSRPVAWWARLAGPLFPLLQHAFARRCGRVLAAIAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E7</accession>
    <name>A0A1E7N5E7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.174</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2G1835 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase RlmG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmG</name>
        <name evidence="2" type="ORF">HS99_0008640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10218"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.174"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RlmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.174" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366884.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7296"/>
    <dbReference type="EnsemblBacteria" id="ARF81127">
        <property type="protein sequence ID" value="ARF81127"/>
        <property type="gene ID" value="B6264_21415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35915">
        <property type="protein sequence ID" value="OEV35915"/>
        <property type="gene ID" value="HS99_0008640"/>
    </dbReference>
    <dbReference type="OMA" id="DFLAWRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052916">
        <property type="term" value="F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01859">
        <property type="entry name" value="23SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017237">
        <property type="entry name" value="rRNA_m2G-MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47816:SF5">
        <property type="entry name" value="PTHR47816:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037565">
        <property type="entry name" value="RRNA_m2G_Mtase_RsmD_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="42931" checksum="0E935A83E15A6771" modified="2017-01-18" version="1">MNPQTTPAEPAPATSFATPWGALDLTRFPADPRERLRAWDAADEYLLRHLAGEADSADGVATELAGRRIAVLGDRWGALTTALAPYGPVQITDSHLGRQATRENLARAGAAVDEARLLTTRDTPPERIDVLLVRVPKSLALLEDQLHRLAPAIHPGTVVVGTGMVTEIHTSTLQLFEKVLGPTRTSLAVRKARLIFCTPDPALDPGPSPWPHRYALPPDIGAAAGRTVVNHAGTFCAERLDIGTRFFLAHLPTPAAGARVVDLGCGNGVVGTAAALTGPGAELVFVDESHQAVASAEETFRANLGPDAPAEFRTADALDPAVFAAGSVDLVLNNPPFHSHQATTDATAWRMFSGARRALRPGGELWVVGNRHLGYHVKLRKLFGNCQLVAGNPKFVVLRAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F2</accession>
    <name>A0A1E7N5F2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0008415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387020.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7251"/>
    <dbReference type="EnsemblBacteria" id="ARF81086">
        <property type="protein sequence ID" value="ARF81086"/>
        <property type="gene ID" value="B6264_21190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35874">
        <property type="protein sequence ID" value="OEV35874"/>
        <property type="gene ID" value="HS99_0008415"/>
    </dbReference>
    <dbReference type="OMA" id="LAWCLHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="41637" checksum="68F30837DF4B02E6" modified="2017-01-18" version="1">MATERSRTIPVARVLQVCLHLLVAGLLALAVARAAFVDRGGDPAAVAAAASATAAVYAVGPRLAAVRRSRRGAALWLALLGVTWAGLLVATQDGVWLAFPLYFLELHLLGRRSGLAAVGLTAAASIAAWSWHQHSFSLAASIGPALGAAVATATVLGYQALYRESEERRRLIDELTAARADAAAAHHAAGVLAERERLAREIHDTLAQSLSSIQLLLRAAQRALPERTEAVAGYVEQARQAAQDNLDEARRFVRALSPPALDGDPLPVALERLCATTTAHSALPVHLHVSGDPVRLPAAQEVALLRIAQSALGNTVRHAKASRAEVTLSYMEGEVALDVFDDGAGFDPAAVAGRTGGDGGFGLPSMRARARALGGSFTVESAPGQGTALAVQLPVGPEVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5G4</accession>
    <name>A0A1E7N5G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5358"/>
    <dbReference type="EnsemblBacteria" id="ARF82929">
        <property type="protein sequence ID" value="ARF82929"/>
        <property type="gene ID" value="B6264_19265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35931">
        <property type="protein sequence ID" value="OEV35931"/>
        <property type="gene ID" value="HS99_0006500"/>
    </dbReference>
    <dbReference type="OMA" id="VTCKQRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17338" checksum="1171BCA8C38D432B" modified="2017-01-18" version="1">MAADPGEGTVTTTAPQKSSADTVTVTRGAESVDPATLPVRPGEEAWTSDEVHELHDELINDLERLRGEIDAADAAIAGLMRDSNDGAGDDQVDAGTKNISRESELALANNARDSLAQTERALARLEGVGFGTCESCGQAIGKARMQAFPRATLCVQCKAKQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M7</accession>
    <name>A0A1E7N5M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554386.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000409.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene486"/>
    <dbReference type="EnsemblBacteria" id="ARF78832">
        <property type="protein sequence ID" value="ARF78832"/>
        <property type="gene ID" value="B6264_07795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36006">
        <property type="protein sequence ID" value="OEV36006"/>
        <property type="gene ID" value="HS99_0031340"/>
    </dbReference>
    <dbReference type="OMA" id="ALWHVWH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19288" checksum="2FB5ADF8DDFD4BDC" modified="2017-01-18" version="1">MDRNSAATTADDFLDQALLEEAAKKSGLLWVRADGESQARPLWHAWHDGAVVVVGDGTEQPLHGLTAGARAVVTVRSKDKGGRLTGWDAEVVELAPEGEAWLGAVEELKGKRLNAPDTDTIAERWARECRVLRLQPAGALTERPGAMPDGSHAARPMPTPATTRRPIPAGLPKLLLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P2</accession>
    <name>A0A1E7N5P2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">HS99_0008650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553629.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000381.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7298"/>
    <dbReference type="EnsemblBacteria" id="ARF82981">
        <property type="protein sequence ID" value="ARF82981"/>
        <property type="gene ID" value="B6264_21425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35999">
        <property type="protein sequence ID" value="OEV35999"/>
        <property type="gene ID" value="HS99_0008650"/>
    </dbReference>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5033204786" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033204785" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="178"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="382" mass="38756" checksum="66CC71FC9EC8A0FB" modified="2017-01-18" version="1">MTAAKGFRAAGVTAGIKASGTPDLALVVNDGPSLAAAGVFTANRVKAAPVLWSQQVLKGGRVSAVVLNSGGANACTGPAGFQDTHATAEHVAAELELNSGEVAVASTGLIGVRLPMDVLLPGVTLAAGQLSETGGEAAAIAIKTTDTVHKTAQFTSPAGWTVGGMAKGAGMLAPSLATMLVVLTTDADLDAADLDAALRGATRTTFDRIDSDGCMSTNDTVLLLASGASGITPDRAEFAEAVRTVSADLARQLIGDAEGASKDIRIDVTGAATEDEAVEVARTISRNNLLKCAIHGEDPNWGRVLSAIGTTSAAFDPDRLDVAINGVWVCKDGGVGEDRELVDMKARDVVITANLNAGTAGASLWTNDLTADYVHENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U4</accession>
    <name>A0A1E7N5U4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene508"/>
    <dbReference type="EnsemblBacteria" id="OEV36062">
        <property type="protein sequence ID" value="OEV36062"/>
        <property type="gene ID" value="HS99_0031440"/>
    </dbReference>
    <dbReference type="OMA" id="GHPWPYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="357" mass="38036" checksum="AFFAF0ABF92EB3D4" modified="2017-01-18" version="1">MALIVVLDHLSGTEVTVEPALTAVPALAAVVSRRTWYPLAIGLCTEAAAFLMAFRSDALGESVHAASVIAILLVATIGWVSATLRLRQEQALADAQLVAAIARRVLLRPVPERVGSVRAAVHYEAAAAHARIGGDLYEVVNTRHGVRAVVGDVRGKGLGAVETAAAVLGAFREAAHQEPALDRVAGWLADSLDRALHENDHPGVEEEFVTLVLIGVRSDGTAELVNCGHPSPLLLRGGLVRPLELTETVPPLGVLDPADVHPPVHRVPLHGGDRVLLFTDGVIEARDRSGAFYPLAERFPRCADGRPADVLQRLHEDVVRHVGRQLGDDAAMLLLQYEPTPPAIAHLPQQTGVLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N600</accession>
    <name>A0A1E7N600_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5016"/>
    <dbReference type="EnsemblBacteria" id="ARF80081">
        <property type="protein sequence ID" value="ARF80081"/>
        <property type="gene ID" value="B6264_15185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36136">
        <property type="protein sequence ID" value="OEV36136"/>
        <property type="gene ID" value="HS99_0031205"/>
    </dbReference>
    <dbReference type="OMA" id="LISNAWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="11328" checksum="6D08AF9633569727" modified="2017-01-18" version="1">MTRSGRWDAEAIFNAELALCELISNAWRHGATPAPVVWFSILDQTLRVTVSDESDALPQPRTSPGLTETGRGLQLVEGLTDRWGVDPQKRGKTTWYELDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N645</accession>
    <name>A0A1E7N645_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="1 2">N5-CAIR mutase</shortName>
            <ecNumber evidence="1 2">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purE</name>
        <name evidence="4" type="ORF">HS99_0031280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290964.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5032"/>
    <dbReference type="EnsemblBacteria" id="ARF80093">
        <property type="protein sequence ID" value="ARF80093"/>
        <property type="gene ID" value="B6264_15260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36148">
        <property type="protein sequence ID" value="OEV36148"/>
        <property type="gene ID" value="HS99_0031280"/>
    </dbReference>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18162" checksum="8EEEB76B203A9038" modified="2017-01-18" version="1">MTNPVVGIVMGSDSDWPVMEAAAQALDEFEIAYEVDVVSAHRMPREMVAYGENAHRRGLKAIIAGAGGAAHLPGMLASVTPLPVIGVPVPLRYLDGMDSLLSIVQMPAGVPVATVSVAGARNAGLLAVRMLAAFDAELTEKMADFQAELNNQATEKGKKLRAKVAGSSSFGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N650</accession>
    <name>A0A1E7N650_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">panD</name>
        <name evidence="2" type="ORF">HS99_0030435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284363.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8113"/>
    <dbReference type="EnsemblBacteria" id="ARF79781">
        <property type="protein sequence ID" value="ARF79781"/>
        <property type="gene ID" value="B6264_13480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36172">
        <property type="protein sequence ID" value="OEV36172"/>
        <property type="gene ID" value="HS99_0030435"/>
    </dbReference>
    <dbReference type="OMA" id="MLYSKIH"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5033204787" description="Aspartate 1-decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033204788" description="Aspartate 1-decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="15704" checksum="C635019DC587C925" modified="2017-01-18" version="1">MLRTMLKSKIHRATVTQADLHYVGSVTVDEDLLDAADLLPGELVHIVDINNGARLETYTIAGPRGTGVIGINGAAARLVHPGDLVILIAYGQMDTAEAKGYEPKVVFVDEHNRITGLGGDPAEAQEGTGLLRGDQAYRGEDGAATAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H9</accession>
    <name>A0A1E7N6H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36317">
        <property type="protein sequence ID" value="OEV36317"/>
        <property type="gene ID" value="HS99_0030285"/>
    </dbReference>
    <dbReference type="OMA" id="AYTKMSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="34136" checksum="9AC0E83036375CB7" modified="2017-01-18" version="1">MEELSFDSTSAEATEEFLSTAYTPMRIGKSAADARTRISRRAAGPLNVDRLSFGYDMAYDAESLGRVCLLSIHAGTVVDRSGADGEQGETVFGPGETFLIAPPDAPYRGEVRSARYTIAMFDTALLDAMAPAGAEGAPVRLTGLRTVDEAANRQLGAAVAYVRDHVLDNPAAYGNELLLTTAAQHLAAATLAALPHTGRTDPVPADRTDATPATLRRAIAFVEANADREISLADIAAAAFVTPRALQYAFRRHLDTTPLGYLRRVRLDAAHRDLLAADPATATVTGIAMHWGFAHPGHFASLYRAAYGRSPGWTLRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J8</accession>
    <name>A0A1E7N6J8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000315.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2647"/>
    <dbReference type="EnsemblBacteria" id="OEV36274">
        <property type="protein sequence ID" value="OEV36274"/>
        <property type="gene ID" value="HS99_0030155"/>
    </dbReference>
    <dbReference type="OMA" id="ISISAHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="45"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="523" mass="54970" checksum="591FADF039138DE7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6K6</accession>
    <name>A0A1E7N6K6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386023.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2609"/>
    <dbReference type="EnsemblBacteria" id="OEV36308">
        <property type="protein sequence ID" value="OEV36308"/>
        <property type="gene ID" value="HS99_0030340"/>
    </dbReference>
    <dbReference type="OMA" id="WELAMSL"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="528"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="609" mass="65273" checksum="D4A02C13FC9F319C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6N2</accession>
    <name>A0A1E7N6N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7165"/>
    <dbReference type="EnsemblBacteria" id="ARF82359">
        <property type="protein sequence ID" value="ARF82359"/>
        <property type="gene ID" value="B6264_28890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36350">
        <property type="protein sequence ID" value="OEV36350"/>
        <property type="gene ID" value="HS99_0029765"/>
    </dbReference>
    <dbReference type="OMA" id="MLPLWGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32084" checksum="76FB89A9F4BE60D8" modified="2017-01-18" version="1">MTSANGPAMTRDEFDALFRQLRRAYLPGPVEAGRRVAAAGLVRTGEVVAMGRPWDSVPGPDNPRPALHQMTELADVTAPEPTVHRDFIGSDYHGKAQTHLDALCHIAYGGLLFAGVRAREVFSSQGAAYGAVTDLLPGLVGRGVLLDVPRLRGTDWLEPGEAIGGSELLVCAEEQGSPLHPQDILLVRTGHLARRRRLGAWDPDDLSAGLHPGAMRTLSESRASALGSDGDNDVRPSPVDGVRSPVHVLAITALGLSLIDNLDLEPLAEACARTSRWEFLLVVAPLNIPRGTGSPVNPLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N723</accession>
    <name>A0A1E7N723_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366369.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene218"/>
    <dbReference type="EnsemblBacteria" id="ARF82252">
        <property type="protein sequence ID" value="ARF82252"/>
        <property type="gene ID" value="B6264_28265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36444">
        <property type="protein sequence ID" value="OEV36444"/>
        <property type="gene ID" value="HS99_0029345"/>
    </dbReference>
    <dbReference type="OMA" id="RWELEIS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="940" mass="98351" checksum="1F4354722F023CA8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N776</accession>
    <name>A0A1E7N776_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388250.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000606.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4878"/>
    <dbReference type="EnsemblBacteria" id="ARF82387">
        <property type="protein sequence ID" value="ARF82387"/>
        <property type="gene ID" value="B6264_29075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36323">
        <property type="protein sequence ID" value="OEV36323"/>
        <property type="gene ID" value="HS99_0029585"/>
    </dbReference>
    <dbReference type="OMA" id="GDDFCQS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13566" checksum="42E32E80C0AE9AA3" modified="2017-01-18" version="1">MTGDPLVREVFPDLLHELTALLEAEGEAELAAGARDLRLVADCGCGDDFCQSFRTEPHRGGQPYGPGHRCVPLLPTEGTLILDVVDGRIVYVEVLGREPLRDLRRPPDQPGHQPDHRPSRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Q0</accession>
    <name>A0A1E7N7Q0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284749.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000510.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4747"/>
    <dbReference type="EnsemblBacteria" id="OEV36732">
        <property type="protein sequence ID" value="OEV36732"/>
        <property type="gene ID" value="HS99_0027290"/>
    </dbReference>
    <dbReference type="OMA" id="GYPWGGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="43211" checksum="CF94FB0EA1CB9236" modified="2017-01-18" version="1">MHASITAAYLARYRSAAAESPVELLPLTGAQRRFLITRRLAPQSRSDLAPLFFAFPGGTLDLDRLGRAAAAVAAGHPALCGAFATVRGTPVLRTGGPSVEVARVAVAPGGSAEGALREALLDWPLDGPALRLLVARQSDGGEELLALALDHAACDEQSIGALLGELGEAYRHDRAPEAAPGPQAVAAFREAVELQLAAEEAAAGPAARAHWGRRLGALTGAGGGAAKAAGLLTERLPAVEGGARSALFPALLDAVGAAARRLHRTDGPLALGYPWGGRPPGAPAVLGCFLNTLVHAVPPRPAADLEALCDDWWDDLDHAGTPFDEVVRAARAAGSPWSGALDAMLTFEDLQRRPPLVLGGVPGREVHLSGRPLAAPLAASASHGEVLTVHLAWDSERFPAADAEAAFGDLLAVLRRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R8</accession>
    <name>A0A1E7N7R8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550688.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2483"/>
    <dbReference type="EnsemblBacteria" id="ARF83023">
        <property type="protein sequence ID" value="ARF83023"/>
        <property type="gene ID" value="B6264_23695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36719">
        <property type="protein sequence ID" value="OEV36719"/>
        <property type="gene ID" value="HS99_0028410"/>
    </dbReference>
    <dbReference type="OMA" id="NLAGWYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="21839" checksum="CA42F63D6D4745F2" modified="2017-01-18" version="1">MAAGVVALVLAAGGGWLLHDGTDGLGGPPLPAPVPPASTAPTAAPTGTAKPTPAPAVPPLAASVPTRIRIPAIKVDAPVTGLGLTPSQQLDTPPTDQRNLTGWYRDGTAPGAAGNALVVGHADTRSGPAVFYRLGLLRVGDTVEVSRKDRRVAVFTVDSVRVIPKRDFPDALVYGPTERAELRLITCGGKFDRKTGYESNTVVFAHLSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7W0</accession>
    <name>A0A1E7N7W0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4806"/>
    <dbReference type="EnsemblBacteria" id="OEV36771">
        <property type="protein sequence ID" value="OEV36771"/>
        <property type="gene ID" value="HS99_0027575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="11966" checksum="6201616061E7A660" modified="2017-01-18" version="1">MHEVRHILAVRYPQLETRTDEVHDIATAALLASGEDAELLVVAARGAGGFPGLRIGSTAPHLAARAGCPTVVLPADPPGPEPREQVVVGLDARRPAEAALESERQVACSCAATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X7</accession>
    <name>A0A1E7N7X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553005.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4816"/>
    <dbReference type="EnsemblBacteria" id="OEV36779">
        <property type="protein sequence ID" value="OEV36779"/>
        <property type="gene ID" value="HS99_0027625"/>
    </dbReference>
    <dbReference type="OMA" id="NCKKHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="42"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="211"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="471"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="560" mass="59615" checksum="412AE3B23EC9ADFC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8A2</accession>
    <name>A0A1E7N8A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287038.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6836"/>
    <dbReference type="EnsemblBacteria" id="ARF78629">
        <property type="protein sequence ID" value="ARF78629"/>
        <property type="gene ID" value="B6264_06620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36925">
        <property type="protein sequence ID" value="OEV36925"/>
        <property type="gene ID" value="HS99_0027070"/>
    </dbReference>
    <dbReference type="OMA" id="RLFEPDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027945">
        <property type="entry name" value="SseB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14581">
        <property type="entry name" value="SseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="27971" checksum="BA2ED842B75BB917" modified="2017-01-18" version="1">MGYPVEQQQGWDGPQAAPSGGAWPANELEQVLTAALGDPGATPRVIEVLARSQVWIPLPAGGDPNGQSLDLPTVELAGAPYVPVFSSQEVFLQQAPGMAFAIAPAWEFARGLPLGVGIAVNPEAAVGIPVPPQGVAELRRGPREAARWEHTENASEAPTGGRVALREPVPGEDPEHFLAACRAELSALPGVLTARRALASIEGEPTVMFVGVQLDPAAPADPGAVNEALGRALGTAPLPGGVHLVLLDLADDPVVEWLLTQVMPFYSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8I5</accession>
    <name>A0A1E7N8I5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366176.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81716">
        <property type="protein sequence ID" value="ARF81716"/>
        <property type="gene ID" value="B6264_24965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37010">
        <property type="protein sequence ID" value="OEV37010"/>
        <property type="gene ID" value="HS99_0004045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="5987" checksum="556BF9D7637FDB81" modified="2017-01-18" version="1">MRDGGDHGGRGGYGFGDFARSGGDHGGRGGRGGYGFDDFGDGGDHGGGYDDWGDGGDWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N902</accession>
    <name>A0A1E7N902_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366168.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6203"/>
    <dbReference type="EnsemblBacteria" id="ARF81560">
        <property type="protein sequence ID" value="ARF81560"/>
        <property type="gene ID" value="B6264_23985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37175">
        <property type="protein sequence ID" value="OEV37175"/>
        <property type="gene ID" value="HS99_0005005"/>
    </dbReference>
    <dbReference type="OMA" id="SICPGNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12107" checksum="1EB42C7DD07239E9" modified="2017-01-18" version="1">MQPAQDPLWICASSPIPAGYVLTDHNPSSSPCLGDAWLMRLVTDGIWTCAGSPIPAGYVMTGHYRTGCRGIGSWFQQVAAPGLSICPGNAVPAGYHLGTYNSAGCAGLGSWVLLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N937</accession>
    <name>A0A1E7N937_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556549.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6158"/>
    <dbReference type="EnsemblBacteria" id="OEV37207">
        <property type="protein sequence ID" value="OEV37207"/>
        <property type="gene ID" value="HS99_0005195"/>
    </dbReference>
    <dbReference type="OMA" id="NMSQMTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33122" checksum="F532645F9B5F2E66" modified="2017-01-18" version="1">MDSSPEAGMRPILVTGAAGSVGAVGRTVVQGLRRRGFQVRALVRQDDDRAQALRATGAEVVVGDLTHARDVADALDGCGRMYFGMAVSAQYLLAAVTTAAVARTYGRLEAFVNMSQLTVSEMDATSGSDSHQHRQQWLVEQVLGWSGLPVVQVRPTVFMENPLFQTVFASVAKDGVIRWPFGEARTSPIAAGDVAAVVEEILADPAGRIGRTYELTGPRSQDVTALAAEISDALHRTVGYTDVPLQEWLDNDLAALGLPAHVLQHISTMARLHVAGRYDRQTDGMAEITGRPAEGVSGFVRKNPGLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N964</accession>
    <name>A0A1E7N964_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1338"/>
    <dbReference type="EnsemblBacteria" id="OEV37236">
        <property type="protein sequence ID" value="OEV37236"/>
        <property type="gene ID" value="HS99_0005385"/>
    </dbReference>
    <dbReference type="OMA" id="QTQNAKY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="853" mass="91374" checksum="0B7E56698685854B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N984</accession>
    <name>A0A1E7N984_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556556.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6163"/>
    <dbReference type="EnsemblBacteria" id="OEV37204">
        <property type="protein sequence ID" value="OEV37204"/>
        <property type="gene ID" value="HS99_0005180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198895" description="PG_binding_1 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12615" checksum="6595063F3CA2C419" modified="2017-01-18" version="1">MRTKLAAVAAGAVVLTGLGIGTATTASASTPAACSYYGYSSDNEAEVSSGDSGPEIKALQCELNYSVRGAGLQVDGVFGKNTLAIVKKFQGCAGLRPDGIVGPLTWAKLDYQSDIDTEANYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A4</accession>
    <name>A0A1E7N9A4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methoxymalonate biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555163.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1295"/>
    <dbReference type="EnsemblBacteria" id="OEV37271">
        <property type="protein sequence ID" value="OEV37271"/>
        <property type="gene ID" value="HS99_0005600"/>
    </dbReference>
    <dbReference type="OMA" id="MDTANAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10773" checksum="FBBD1D526AA6E62D" modified="2017-01-18" version="1">MTPEQQTEKAPFDTDAVVDEITRFVAEQTRTTPDVDQDLFTTGIANSMFAMQLVVFLEQAYRVTVAGPDLQLSNFRTIKSMAALVGRLQAESAADSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA73</accession>
    <name>A0A1E7NA73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558112.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82507">
        <property type="protein sequence ID" value="ARF82507"/>
        <property type="gene ID" value="B6264_29815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37393">
        <property type="protein sequence ID" value="OEV37393"/>
        <property type="gene ID" value="HS99_0006340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9770" checksum="CF00893024193C5E" modified="2017-01-18" version="1">MSDFPQADDSLGLMTRFFVEDVNNHRFRYHLLRLQAMAGLTEQDVEELGELGRLVFQNGQTPNQAADQAAKIAGRPDASPLAITIAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC4</accession>
    <name>A0A1E7NAC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280711.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1709"/>
    <dbReference type="EnsemblBacteria" id="ARF79904">
        <property type="protein sequence ID" value="ARF79904"/>
        <property type="gene ID" value="B6264_14210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37647">
        <property type="protein sequence ID" value="OEV37647"/>
        <property type="gene ID" value="HS99_0025425"/>
    </dbReference>
    <dbReference type="OMA" id="RDPYLFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="599" mass="65479" checksum="28F95176FAB5A722" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF3</accession>
    <name>A0A1E7NAF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1692"/>
    <dbReference type="EnsemblBacteria" id="ARF79919">
        <property type="protein sequence ID" value="ARF79919"/>
        <property type="gene ID" value="B6264_14300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37662">
        <property type="protein sequence ID" value="OEV37662"/>
        <property type="gene ID" value="HS99_0025510"/>
    </dbReference>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="35242" checksum="A40A9FCB00D1C733" modified="2017-01-18" version="1">MSTAPLLSVVMPIYNEQEALPLTVERLRPILDGLGIDYEVVGVDDGSRDATPVLMQKIRQDWPEFRIVRFARNSGHQAALTAGIHRALGDYVVSIDADLQDPPEKIPEMLELAREQGLDVVYGVRGDRGTDTAFKRRTAGAYYWLMRKLVGKRMPNQAGDFRLLSRNAVDALKQLPEHQPVYRLLVPWLGFPSGEVVYVREERVAGGTHYPLSKMVRLALDSITNFSAAPLRLATYLGLVSFVVCIGLAIHATVAYALGSTVPGWSSLFIGMLFLGGVQLICVGLLGEYVGRIYSAVQARPTYFVGYDSAEDDERGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAH2</accession>
    <name>A0A1E7NAH2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385840.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1686"/>
    <dbReference type="EnsemblBacteria" id="ARF79925">
        <property type="protein sequence ID" value="ARF79925"/>
        <property type="gene ID" value="B6264_14330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37668">
        <property type="protein sequence ID" value="OEV37668"/>
        <property type="gene ID" value="HS99_0025540"/>
    </dbReference>
    <dbReference type="OMA" id="SERECRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="33138" checksum="9731CF56AB7165BE" modified="2017-01-18" version="1">MSVDFVIPYYGDPEYLFATIDSIRAQHQQDWRLTVVDDQYPGNRALEYIEGLNDERIRYVRNEERLGPNGNTYKASTLAEREFVSMMGADDLLEPNYLDVVLERMKADPNAIAVQPGVKVMDSDGVLVPSLGIGDKVKRRIAAPARKAGLISGEDAVKSLLSGNWLYTPSLLYRQSALSKIPYRPDIDAVHDLAFMVDMLMEGGNLLVDEREVFRYRRHQASDSSTRVKDGKRFDEELRYYGLIAKELRAKGWNAAARSADLHLSSRLHALMVAAGRLGAGDFAHAGAMVGRAVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT5</accession>
    <name>A0A1E7NAT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78067">
        <property type="protein sequence ID" value="ARF78067"/>
        <property type="gene ID" value="B6264_03265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37799">
        <property type="protein sequence ID" value="OEV37799"/>
        <property type="gene ID" value="HS99_0024730"/>
    </dbReference>
    <dbReference type="OMA" id="APRINSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="26458" checksum="EBB61C59D2DE7919" modified="2017-01-18" version="1">MLTGSRTADIEHRVEDTSDFGLIVHRVASTTSEQDIPLPHSLLIQYRDLDDLAEWAAENQLQFVPCFALQAAIMLSRLPLGERTAGPVSGEPLEQYDLRRRQYVPVQRARSDGLFRFRRRDSKDVCQLQRGGQWYEIAHEYGVYQELQRVSIDGQGGDVMRWFPEKAPGREAFGRLHVDWGFPLPDLQRKIAVLCSGLAPQIHAKAQNIAYDNVPRAVARMIADSLGQCLGDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB45</accession>
    <name>A0A1E7NB45_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor SigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278261.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000894.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2109"/>
    <dbReference type="EnsemblBacteria" id="ARF79461">
        <property type="protein sequence ID" value="ARF79461"/>
        <property type="gene ID" value="B6264_11525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37911">
        <property type="protein sequence ID" value="OEV37911"/>
        <property type="gene ID" value="HS99_0023855"/>
    </dbReference>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="26737" checksum="408F740782A80F41" modified="2017-01-18" version="1">MTVADDDAALLARHVAGDPQAFGQLVNRHRDRLWAVALRTLGDREEAADALQDALVSAFRAAPGFQGRSAVTTWLHRIVVNACLDRARRSATRRTTPLDDDPQRLDSLVGTAEPADSPVVRAEVHRELTAALAELPVEQRAALVLVDMQGYPVAEAAELLGVPVGTVKSRCARGRARLLPLVRHLRETDGARQDVSRETPGRGAPGRGASGSPGTAPPPRHDAQGNPTGPRTVTGTGPSTGRTMLEGDASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB57</accession>
    <name>A0A1E7NB57_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278247.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2123"/>
    <dbReference type="EnsemblBacteria" id="ARF79448">
        <property type="protein sequence ID" value="ARF79448"/>
        <property type="gene ID" value="B6264_11450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37898">
        <property type="protein sequence ID" value="OEV37898"/>
        <property type="gene ID" value="HS99_0023780"/>
    </dbReference>
    <dbReference type="OMA" id="NGYALMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="31327" checksum="D43852AD44EEC468" modified="2017-01-18" version="1">MELGLIGLGKMGGNMRERIRRAGHTVIGYDRNPEISDVESLQELVTKLQGPRVVWVMVPAGAATQATVDELAELLSPGDVVVDGGNSRWTDDIKHAEALAAKGIGFVDCGVSGGVWGLENGYALMYGGDAEHVARVQPVFDALKPEGDFGSVHAGAVGAGHFAKMVHNGIEYAMMQAFAEGWELLEAAPEVTDVREVFRSWQEGTVIRSWLLDLAVRALDEDEHLAKLRGWAADSGEGRWTVEAAIDHAVPLPAITASLFARFASRQDDSPQMKMIAALRNQFGGHAVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBN8</accession>
    <name>A0A1E7NBN8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="9" type="ORF">HS99_0023240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289386.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000540.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5942"/>
    <dbReference type="EnsemblBacteria" id="ARF79676">
        <property type="protein sequence ID" value="ARF79676"/>
        <property type="gene ID" value="B6264_12865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38116">
        <property type="protein sequence ID" value="OEV38116"/>
        <property type="gene ID" value="HS99_0023240"/>
    </dbReference>
    <dbReference type="OMA" id="YAQPKQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="959" mass="104036" checksum="2EF49F9F2A4F23FC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW9</accession>
    <name>A0A1E7NBW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287423.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene478"/>
    <dbReference type="EnsemblBacteria" id="ARF78838">
        <property type="protein sequence ID" value="ARF78838"/>
        <property type="gene ID" value="B6264_07835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38177">
        <property type="protein sequence ID" value="OEV38177"/>
        <property type="gene ID" value="HS99_0023620"/>
    </dbReference>
    <dbReference type="OMA" id="RGMRPDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22319" checksum="15CA0D282C6EDB98" modified="2017-01-18" version="1">MSEFGPARAALADTYVGEDAVLTYARAQSARTGIRAIGPSGGACLRLLAAALDAKAVAEIGTGTGVSGVYLLRGMRPDGVLTTVDSEPVRQQLAREAYQAAGFAANRSRFIPGRALEVLPRLADGQYDLVFCDGDPAESREYLLESLRLLRPGGMVCFEGVFQEGRLAEPELQDPQTGAVRDLVRDVRESDALLPALLPVSDGLLCAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBY5</accession>
    <name>A0A1E7NBY5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene466"/>
    <dbReference type="EnsemblBacteria" id="OEV38197">
        <property type="protein sequence ID" value="OEV38197"/>
        <property type="gene ID" value="HS99_0023560"/>
    </dbReference>
    <dbReference type="OMA" id="WTGRANS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="177"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="33024" checksum="F4F238AED9E8973B" modified="2017-01-18" version="1">MRRLSEFVDDRPVFRDAIGVLTSWDDHGLVVEPRAGGPVAFPEKLLVAGKVVPPFPARRAPLPTATAVELQRIAGRGWPAVEQERLGEWTLRAAAGFTRRANSVQALGDPGLPLPQALAAVRAWYAERALPAYVEVISPGSPEDLRAELDRLGAGYAPTLVLTAPLAAVARSGAGHERVRLSRTADAGWMSLYRRVSADPGVEEAARQVLHGGPSVWFATVPGAEGQPPLAIGRCVVDGPWACFGAVEVQPYARRAGLATAVMAVLAARAAEEGASGAYLQVEAENGGAIALYDGLGFTTSHTYHYALLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBZ2</accession>
    <name>A0A1E7NBZ2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">HS99_0021885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290033.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3303"/>
    <dbReference type="EnsemblBacteria" id="ARF80279">
        <property type="protein sequence ID" value="ARF80279"/>
        <property type="gene ID" value="B6264_16395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38212">
        <property type="protein sequence ID" value="OEV38212"/>
        <property type="gene ID" value="HS99_0021885"/>
    </dbReference>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="553" mass="60366" checksum="ADED87B4F10FF270" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCH4</accession>
    <name>A0A1E7NCH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene257"/>
    <dbReference type="EnsemblBacteria" id="ARF82217">
        <property type="protein sequence ID" value="ARF82217"/>
        <property type="gene ID" value="B6264_28050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38392">
        <property type="protein sequence ID" value="OEV38392"/>
        <property type="gene ID" value="HS99_0021005"/>
    </dbReference>
    <dbReference type="OMA" id="NARIWPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="10312" checksum="089932215D43E3B8" modified="2017-01-18" version="1">MPSSPHPHEDLLAHLARTSPLGPREAARVVAEVLAYFSETTEEYVRRRHGELQARGLTNERIFARLAEELPARRVAAPELSARQLRRIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR5</accession>
    <name>A0A1E7NCR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288432.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000653.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3062"/>
    <dbReference type="EnsemblBacteria" id="ARF82127">
        <property type="protein sequence ID" value="ARF82127"/>
        <property type="gene ID" value="B6264_27535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38477">
        <property type="protein sequence ID" value="OEV38477"/>
        <property type="gene ID" value="HS99_0021510"/>
    </dbReference>
    <dbReference type="OMA" id="CDARLTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015057">
        <property type="entry name" value="Rv2632c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038070">
        <property type="entry name" value="Rv2632c-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08962">
        <property type="entry name" value="DUF1876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143212">
        <property type="entry name" value="SSF143212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9545" checksum="2E7B4780EE8F3670" modified="2017-01-18" version="1">MHNQWDVELSFDEDGVHTTCDARLTGARAPGLSAHGEAEKSADDRPLARIGEEVAASRALEELSRKLRAQATGEIEDEGHRPGYLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND26</accession>
    <name>A0A1E7ND26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0021010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554462.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene258"/>
    <dbReference type="EnsemblBacteria" id="ARF82216">
        <property type="protein sequence ID" value="ARF82216"/>
        <property type="gene ID" value="B6264_28045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38393">
        <property type="protein sequence ID" value="OEV38393"/>
        <property type="gene ID" value="HS99_0021010"/>
    </dbReference>
    <dbReference type="OMA" id="DIHTWMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="616" mass="68315" checksum="877E599DC49477D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDA3</accession>
    <name>A0A1E7NDA3_KITAU</name>
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        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020430</name>
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    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
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            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene592"/>
    <dbReference type="EnsemblBacteria" id="OEV38628">
        <property type="protein sequence ID" value="OEV38628"/>
        <property type="gene ID" value="HS99_0020430"/>
    </dbReference>
    <dbReference type="OMA" id="PTENPTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="286"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="437"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="816"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="434"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1308" mass="134436" checksum="D4C7A037A2BDD945" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE3</accession>
    <name>A0A1E7NDE3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene639"/>
    <dbReference type="EnsemblBacteria" id="OEV38710">
        <property type="protein sequence ID" value="OEV38710"/>
        <property type="gene ID" value="HS99_0020190"/>
    </dbReference>
    <dbReference type="OMA" id="VEDNHPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
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    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15345" checksum="8F090131EF0DD824" modified="2017-01-18" version="1">MEGVWRFRVPAVEASVPRTRHAVRDRLLAQGMTGVRYQELVDDLLLIVSELVGNAVRHAAELSPEVTTELSVRRGWVRVSVEDGDPYRPKALESDTARTGGRGLLLVKSVTLQAGGVCDVEQTGEGGKVIWASLPVPPGPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH8</accession>
    <name>A0A1E7NDH8_KITAU</name>
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        <submittedName>
            <fullName evidence="2">DUF1049 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene664"/>
    <dbReference type="EnsemblBacteria" id="OEV38704">
        <property type="protein sequence ID" value="OEV38704"/>
        <property type="gene ID" value="HS99_0020065"/>
    </dbReference>
    <dbReference type="OMA" id="VWFLFAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8540" checksum="7663091FEC21D8B7" modified="2017-01-18" version="1">MSDGSSRPQRSEIGGIPTRYIGIGVIVVLAVWFLFANLDKVKIQFWVFTVTAPLWIALLATLVAGGAIGWLLKGRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR3</accession>
    <name>A0A1E7NDR3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557887.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000233.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6264"/>
    <dbReference type="EnsemblBacteria" id="ARF81217">
        <property type="protein sequence ID" value="ARF81217"/>
        <property type="gene ID" value="B6264_22020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38812">
        <property type="protein sequence ID" value="OEV38812"/>
        <property type="gene ID" value="HS99_0019285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11261" checksum="2D1643FC7E994DDE" modified="2017-01-18" version="1">MAVIGRAAAGVVSLAILLAPVAVTAGDQQAPPVGTGRWEVSASAANVRVDHFGDGTVIGQAQAGDRVEVVDTWTSPLGTRWAKVLVSRTGVTGWVLWVLLTHSDPPPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE81</accession>
    <name>A0A1E7NE81_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366144.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4377"/>
    <dbReference type="EnsemblBacteria" id="ARF83239">
        <property type="protein sequence ID" value="ARF83239"/>
        <property type="gene ID" value="B6264_30330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39009">
        <property type="protein sequence ID" value="OEV39009"/>
        <property type="gene ID" value="HS99_0018060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26403" checksum="6AFC835DE37F5A70" modified="2017-01-18" version="1">MNQPSRPNPFAPFGQEQPDPKAGDAPGTLRAAAAQRARKLTAPGSVLDRRRREVLAALNGDWDDAQPWIKAVVYLLALTAGVLLLAAAGGILLTALTDLVNAVHLPTTLPAHSTGLVRTVTDPVHRYLAARTAGVLPVTGTAAYTLWKATGLAAALIAFVTRGATARLAWTAWSCAALAMVWAGTDPAGRPVAVGITAAAIAFVSLFALRGLSFSLRPVIYNMPRNEVAAPTINVTIPAQPGPAQDTDPAREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEK3</accession>
    <name>A0A1E7NEK3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoA ester lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0018245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557515.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1024"/>
    <dbReference type="EnsemblBacteria" id="OEV39146">
        <property type="protein sequence ID" value="OEV39146"/>
        <property type="gene ID" value="HS99_0018245"/>
    </dbReference>
    <dbReference type="OMA" id="ANCHRSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30779" checksum="6361E20000AD7452" modified="2017-01-18" version="1">MNPLTLRAARAWISVPAPAVNRFESAKACGAHVALVDLEDSVAPAKKQHARTIAERFFDGYETSPSLLGVRINAPVLLDGIRDIAAIADWRARPDIVLVPKVESPRDLDLVAGALDADDYRPHLFALIETPRAIEQIREITRAARISGAVFGTADYATAVSCGMGWEPTLHARSAVANSVAAAGLVAIDSPYFQMDDPDGLRVEAERAKALGFHGKGAIHTRQLPVITEVFSPSEQDIADARTILGAGRDSGNNITSVGGQMVGRPFFTRAQNLLAQVDTQREGQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEN1</accession>
    <name>A0A1E7NEN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdhA</name>
        <name evidence="6" type="ORF">HS99_0000015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285072.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3463"/>
    <dbReference type="EnsemblBacteria" id="OEV39157">
        <property type="protein sequence ID" value="OEV39157"/>
        <property type="gene ID" value="HS99_0000015"/>
    </dbReference>
    <dbReference type="OMA" id="WRRIKVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="46"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="512"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="647" mass="71873" checksum="88E59B61F783C47D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF90</accession>
    <name>A0A1E7NF90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0001290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1545"/>
    <dbReference type="EnsemblBacteria" id="OEV39371">
        <property type="protein sequence ID" value="OEV39371"/>
        <property type="gene ID" value="HS99_0001290"/>
    </dbReference>
    <dbReference type="OMA" id="DWIRHIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="8994" checksum="B6FA72D005B76173" modified="2017-01-18" version="1">MTILWALIAGLVVGVLAKLVLPGRQPVPLWLTVLVGVAGAVLGNAAASYFGVRHTAGIDWIRHLMQVGVAAVLIALVSPAYAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI5</accession>
    <name>A0A1E7NFI5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">HS99_0001525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286012.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene555"/>
    <dbReference type="EnsemblBacteria" id="OEV39408">
        <property type="protein sequence ID" value="OEV39408"/>
        <property type="gene ID" value="HS99_0001525"/>
    </dbReference>
    <dbReference type="OMA" id="YERHAET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21035" checksum="A559E55B1D38477B" modified="2017-01-18" version="1">MPIPPQDRSSDPPREGAARPPQGHLPEPAPPTAEAEPGPDAATGPAGDEDEYAAALKEVEDRWRRALADLDNLRKRHARELDRERAVERARTAAAFLPVIDNLELALNHAGSDPGAIVEGVRAVRDQAVSILERLGYERHAETGVPFDPSRHEVVGVVQDPDAEPNTVAQVLRPGYGEAERQLRPAAVTVAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFJ6</accession>
    <name>A0A1E7NFJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gas vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285891.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5092"/>
    <dbReference type="EnsemblBacteria" id="OEV39476">
        <property type="protein sequence ID" value="OEV39476"/>
        <property type="gene ID" value="HS99_0001920"/>
    </dbReference>
    <dbReference type="OMA" id="MNPPGNT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031411">
        <property type="term" value="C:gas vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000638">
        <property type="entry name" value="Gas-vesicle_GvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00741">
        <property type="entry name" value="Gas_vesicle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0304">Gas vesicle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="8507" checksum="6471BDD9B44A27D8" modified="2017-01-18" version="1">MNPPGNTPAATTGAPPSQQQVALIDLLDRLLSGGVVITGDLVLSVADIDLVRISLRALITSISERTPAPWAAHVPSEERGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL4</accession>
    <name>A0A1E7NFL4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39425">
        <property type="protein sequence ID" value="OEV39425"/>
        <property type="gene ID" value="HS99_0001620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17211" checksum="4AF3945906F709E9" modified="2017-01-18" version="1">MGMARNDHSNMAKLIRQESQALAARYPDVHSTTTAYVGGTFDENYVTVMAFEKDSAISDQGRSQILAGIWRPANAPGMTVVHGQVSNVDPGSLGGTLQCAETYTKTATTDAFGNSVYSTTQCAWVDVNTVAVIGISDAVSGQDVTKGAEIAREFRAAAESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFU6</accession>
    <name>A0A1E7NFU6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0002095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5056"/>
    <dbReference type="EnsemblBacteria" id="OEV39505">
        <property type="protein sequence ID" value="OEV39505"/>
        <property type="gene ID" value="HS99_0002095"/>
    </dbReference>
    <dbReference type="OMA" id="KYPNECI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199104" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="426"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="56662" checksum="5701DB3BD67C247A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFX0</accession>
    <name>A0A1E7NFX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6747"/>
    <dbReference type="EnsemblBacteria" id="OEV39548">
        <property type="protein sequence ID" value="OEV39548"/>
        <property type="gene ID" value="HS99_0002365"/>
    </dbReference>
    <dbReference type="OMA" id="EQWINLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17515" checksum="281C046C6BFB4F7D" modified="2017-01-18" version="1">MSDVTVVPAERRVFVDKQSPKAYKALLAAAEAARSVAAEAGLDRRLVELVNLRVSQINGCAYCLNVHTRAALREGETTQRLGVLPAWRDTELFTARERAALALAEATTDPSDAAAQQAAYMLARDALTEEEISAAIWVAIAINSFNRVSIMSKHPVRPTPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG99</accession>
    <name>A0A1E7NG99_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amylo-alpha-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385960.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2885"/>
    <dbReference type="EnsemblBacteria" id="OEV39726">
        <property type="protein sequence ID" value="OEV39726"/>
        <property type="gene ID" value="HS99_0003450"/>
    </dbReference>
    <dbReference type="OMA" id="GAPWFFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032856">
        <property type="entry name" value="GDE_N_bis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14742">
        <property type="entry name" value="GDE_N_bis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDE_N_bis" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="683" mass="74136" checksum="8696844412F2FF2A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG3</accession>
    <name>A0A1E7NGG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2903"/>
    <dbReference type="EnsemblBacteria" id="OEV39738">
        <property type="protein sequence ID" value="OEV39738"/>
        <property type="gene ID" value="HS99_0003535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12398" checksum="05B76B21F3EE3585" modified="2017-01-18" version="1">MGPCFPRRSMQIAVQDVLDRDRVVLVPPLARTLVTPATGMVPRRLVVTARVGDDRVVLDFHARTAARIANPSETSLRPFSVHETLGPCRVEAVIGGRLLAFETGGIVEFAGGAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ2</accession>
    <name>A0A1E7NGJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5065"/>
    <dbReference type="EnsemblBacteria" id="OEV39831">
        <property type="protein sequence ID" value="OEV39831"/>
        <property type="gene ID" value="HS99_0002050"/>
    </dbReference>
    <dbReference type="OMA" id="MGRTIRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="59"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="31343" checksum="8192DDCBA763A36A" modified="2017-01-18" version="1">MNRPEYVDLPPAQVWARELDAGTYWCSERTMYRILNAAGQSGERRRQATHPAKTVPQLLATAPCQVLTWDITKLRGPNKGEWYHLYAIIDIYSRYICGWTVEAAEDSHRAEELIRETIERNGIVPETVHADRGTSMTSKAVSQLLIDLGVTRSHSRPKVSNDNPYSESQFKTIKYSTDFPEYFNSLTHAREWCEGFFTYYNHEHRHSGIGLHTPASVHFGAADLVREQRAVTLTEAYARHPERFARRPKPPEIPQKVWINQPKPETVPAQQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ7</accession>
    <name>A0A1E7NGJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5105"/>
    <dbReference type="EnsemblBacteria" id="OEV39826">
        <property type="protein sequence ID" value="OEV39826"/>
        <property type="gene ID" value="HS99_0001860"/>
    </dbReference>
    <dbReference type="OMA" id="IDNRDPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017881">
        <property type="entry name" value="NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40562">
        <property type="entry name" value="PTHR40562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13084" checksum="FBDE49E5CE5F4712" modified="2017-01-18" version="1">MHDVQIHDGTRWHAVCTLDDLQPGRGRAVLLEDARQVAVFVDRAGTLYAVDNLDPFSGAQVLSRGLLGSRGDRPTLASPMYKQVFDLTDGRCLDDETAPDGSPAVLKIWPVRLAGSVAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>S4S395</accession>
    <name>S4S395_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CtcM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ctcM</name>
        <name evidence="3" type="ORF">HS99_0013320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Metab. Eng." volume="19" first="69" last="78">
            <title>Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Cheng X."/>
                <person name="Liu Y."/>
                <person name="Deng Z."/>
                <person name="You D."/>
            </authorList>
            <dbReference type="PubMed" id="23800859"/>
            <dbReference type="DOI" id="10.1016/j.ymben.2013.06.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">F3</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM627755">
        <property type="protein sequence ID" value="AEI98656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597156.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5212"/>
    <dbReference type="EnsemblBacteria" id="ARF80635">
        <property type="protein sequence ID" value="ARF80635"/>
        <property type="gene ID" value="B6264_18540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33532">
        <property type="protein sequence ID" value="OEV33532"/>
        <property type="gene ID" value="HS99_0013320"/>
    </dbReference>
    <dbReference type="KEGG" id="ag:AEI98656"/>
    <dbReference type="OMA" id="WNMAGEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEI98656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="15052" checksum="4283024D9A52EC5D" modified="2013-10-16" version="1">MPFTAKEAAYLASQPLARLATVDGRGQPHVVPLGFHYNAELGTVDVTGRGMARSLKYRHVQGHPRVSLVVDDIVDAQRWVVRGIEIRGTAVALATGGKEILPHVDDELIRITPERIVSWGIDSDCQAPPLARNVGAGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV66</accession>
    <name>A0A1E7MV66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553776.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000131.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6899"/>
    <dbReference type="EnsemblBacteria" id="OEV32315">
        <property type="protein sequence ID" value="OEV32315"/>
        <property type="gene ID" value="HS99_0016545"/>
    </dbReference>
    <dbReference type="OMA" id="AWINNAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="338" mass="36389" checksum="23C254819CE923A9" modified="2017-01-18" version="1">MRTRTHSEPRTVVITGATAGVGRACVRAFATDGNRLVLVARGVAGLRAASAEAQVAGSPVRTILADVSDPEACEAAAARAEAEFGPIDVWVNDAFVSVFAPFTEISPEEYRRVTEVTYLGYVNATRAALKRMLPRDHGTIVQVGSAIAYRGIPLQTAYSGAKHAIQGWHEALRCELLASRTGVRVTMVQLPAVNTPQFDWVLNRLRGQTRPVAPVAQPEVAARAVRYAADHPRRREYWVGGSTAATLIANAVAPGLLDRYLARTGIDAQQDQGRRNPEDHANLWAPSDASHDHGAHGRFDEESHERSAQLWASQHHGLLATGGAVLVGAAVRALARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV78</accession>
    <name>A0A1E7MV78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289635.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000184.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6929"/>
    <dbReference type="EnsemblBacteria" id="OEV32340">
        <property type="protein sequence ID" value="OEV32340"/>
        <property type="gene ID" value="HS99_0016700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046263">
        <property type="entry name" value="DUF6296"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19813">
        <property type="entry name" value="DUF6296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7499" checksum="D55551C87A799A3C" modified="2017-01-18" version="1">MSTAKRYRLVAADPYREFVLTATGAMGSEGTQVYVDESGAVRAEIDGDGEVRTITTALPLGRPVRAEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE4</accession>
    <name>A0A1E7MVE4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0017020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32395">
        <property type="protein sequence ID" value="OEV32395"/>
        <property type="gene ID" value="HS99_0017020"/>
    </dbReference>
    <dbReference type="OMA" id="WQLTATI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="27337" checksum="29DF3F136A4CB833" modified="2017-01-18" version="1">MCGRFVSTTTPQDLVSLLGELRWDPAETLAPSWNVAPTDPVPAVLERLDRDTGEVLRQLRPLRWGLVPSWSKDPSGAARMINARSETVDTKPAFRKAFAARRCVIPADGYYEWREVPATDDRRKYKQPYFLSTGGLMLMAGLYEFWRDPSRPEDDPLAWLATATVITTDATDSAGRVHDRMPLTIAPGDLPTWLSPGHTEPAELHHLLRRPADGALRVRAVPPTVNSVRNNGPELLATAPDPLGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG3</accession>
    <name>A0A1E7MVG3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0017180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291082.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7520"/>
    <dbReference type="EnsemblBacteria" id="OEV32421">
        <property type="protein sequence ID" value="OEV32421"/>
        <property type="gene ID" value="HS99_0017180"/>
    </dbReference>
    <dbReference type="OMA" id="VMTGRRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21306" checksum="2DAFD95E8CE27F3A" modified="2017-01-18" version="1">MSAPISDPDEALRVLLEGNARFVAGSPEHPNQDAGRRAALAPGQKPFAVLFGCSDSRLAAEIIFDQGLGDLFVVRTAGHVTGVEALGSVEYGVAVLDCPLVVVLGHDSCGAVAAALDSLEGRLPGGFVRDVVERVTPSVLSARAAGIEEPEAIVDEHIRQTVDLLLERSQLLASRVAEGRLAVVGLSYRLHDGRARTVAARGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVN5</accession>
    <name>A0A1E7MVN5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290123.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000691.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1233"/>
    <dbReference type="EnsemblBacteria" id="OEV32484">
        <property type="protein sequence ID" value="OEV32484"/>
        <property type="gene ID" value="HS99_0017550"/>
    </dbReference>
    <dbReference type="OMA" id="HRMDGPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="23532" checksum="36E249448B1775FB" modified="2017-01-18" version="1">MVPVVPDPGVLHPFPEQPRVVLLKPLVTSPLIEVGEYSYYDDPEDPTAFETRNVLYHYGPERLVIGRFCAFAQGVRFVMNGANHRMDGPSTFPFPIMGGAWAEHFDLLSGLPGRGDTVVGHDVWLGYRTTVMPGVRIGNGAIVAAGSVVTSDIPDYAIAGGNPAKVVRMRYEEDEVARLLAVAWWDWPVEHLTRHLRTVMSGSVEELEAAAPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD7</accession>
    <name>A0A1E7MWD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285501.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7835"/>
    <dbReference type="EnsemblBacteria" id="ARF78226">
        <property type="protein sequence ID" value="ARF78226"/>
        <property type="gene ID" value="B6264_04220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32734">
        <property type="protein sequence ID" value="OEV32734"/>
        <property type="gene ID" value="HS99_0015865"/>
    </dbReference>
    <dbReference type="OMA" id="YRFAHRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="17861" checksum="C3A6753D9096A535" modified="2017-01-18" version="1">MTNPRPHHYRFAHRELPRHLLKFGPQVTSPAPNGGSLVPAFTKLWNSFGETLPPEDRLPSNGLDCRHVEVEGTRLLLVTLPTPAGTTEAYFCASVLPKGANAVRYLTLEHAINPFDGSPGTVLGEWTTESHLNHGPGPSPVADLFVASVVQLVAPKKRGFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI5</accession>
    <name>A0A1E7MWI5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0015660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387072.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7874"/>
    <dbReference type="EnsemblBacteria" id="ARF82618">
        <property type="protein sequence ID" value="ARF82618"/>
        <property type="gene ID" value="B6264_04425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32797">
        <property type="protein sequence ID" value="OEV32797"/>
        <property type="gene ID" value="HS99_0015660"/>
    </dbReference>
    <dbReference type="OMA" id="LGWSPHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="24781" checksum="FB6C7FF43A9E9034" modified="2017-01-18" version="1">MLLAQTAFETRMLLRNGEQLLLTVVIPTVLLVLFSAVDVVAVEGPGKRVDFLAPGLLALAVMSTAFTGQAIATGFERRYGVLKRLGASPLPRWTLLTAKTGCVLVTEVLQVALLSVIALALGWSPHGNPLAVAALLVLGTAAFSGLGLLMAGTLRAEATLAAANLVFILLLLAGGVIVPLGKFPGAVRSVLELLPISALSDGLRSVLQQGAGVPWSDLGVLGAWAVLGLAAAARFFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX3</accession>
    <name>A0A1E7MWX3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5784"/>
    <dbReference type="EnsemblBacteria" id="ARF81340">
        <property type="protein sequence ID" value="ARF81340"/>
        <property type="gene ID" value="B6264_22700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32930">
        <property type="protein sequence ID" value="OEV32930"/>
        <property type="gene ID" value="HS99_0013680"/>
    </dbReference>
    <dbReference type="OMA" id="PCNQAAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="13234" checksum="009DF0D55B411B4B" modified="2017-01-18" version="1">MEFKVKPGELDGCGQSAQHIGGLIPGETSKISDPCNQAAGGLKGWLTAGAIQNCGTNWKTLLDKLGTDMGDVGTKLGTSATYYRQAEQNAHNSMKNPSAPAANGSEPDPFGTDFTPGPVKPRSAKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX55</accession>
    <name>A0A1E7MX55_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Limonene-1,2-epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279839.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000420.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5679"/>
    <dbReference type="EnsemblBacteria" id="ARF81438">
        <property type="protein sequence ID" value="ARF81438"/>
        <property type="gene ID" value="B6264_23235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33022">
        <property type="protein sequence ID" value="OEV33022"/>
        <property type="gene ID" value="HS99_0014205"/>
    </dbReference>
    <dbReference type="OMA" id="DATWTYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14442" checksum="4E004AE273D54664" modified="2017-01-18" version="1">MQQTDARTVVTEYVTRLAAGERDAAIALFAEDATWTYPGNLELSRTWHGKQEIFGDFLGQVGTLFAPDGLPTLTLTHVLADGPQAVAEWTAVGKAANGAAYENHCLGVFTVENGLITAVREYLDTHHVAQTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXD4</accession>
    <name>A0A1E7MXD4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387577.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5608"/>
    <dbReference type="EnsemblBacteria" id="OEV33079">
        <property type="protein sequence ID" value="OEV33079"/>
        <property type="gene ID" value="HS99_0014555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="28588" checksum="35CA4ED0B6C91448" modified="2017-01-18" version="1">MTTPGTSPLTTADLVDGWRRVGVRPDMALIVHSSLSSLGRVEGGAEAVVASLREAVGPGGTVVVPTFTSGTVCDPAPDHAGLPTPRIAELRDAVPLFHPDMPSRMGAIAEALRALPDSLRSTHPQASVAAVGAHAREVTARRSFGFAVGRESPFGALHDLGGYVLLVGVGHNRNTFLHYAETFAPNRRLKLRRFPMAIQGERVWLEAPDVGNDNDTHFPVVGREFEARAGIREVLVGNAPCRLVPVRELIPFAVRRLTELLAADGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA2</accession>
    <name>A0A1E7MYA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553451.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3999"/>
    <dbReference type="EnsemblBacteria" id="ARF80494">
        <property type="protein sequence ID" value="ARF80494"/>
        <property type="gene ID" value="B6264_17665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33391">
        <property type="protein sequence ID" value="OEV33391"/>
        <property type="gene ID" value="HS99_0012440"/>
    </dbReference>
    <dbReference type="OMA" id="ERRTRMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="35850" checksum="86B3165750917E2A" modified="2017-01-18" version="1">MTCANPLDPVALLGADQQHIATRAQLRRLGVPSGTIAHRLRPGGPWQQVLPRVICLQNGRLTIHQRLRAALAYASPKGRQPQPGEVLLTGFTVLAEAGLPSAGHPADLAEVEVLIPTQRRVGDREFVRVHRASGAMPGGFQRDDGLWSATVARALADVAPQETGQRRFRALCAEAVQRRHCELGELLDQLLARPGALALPQVARAVEDLTAGARSVVEGEAREVLAHAGLPEPLWNPVLFLDGRFLAAPDAYWPHACVALEIDSRAYHLRPSDHERGLARANRLTAAGLPVVRATPAQLRRDPAPVLHELTALVTTGPHGPHGRISWRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA5</accession>
    <name>A0A1E7MYA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287583.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3981"/>
    <dbReference type="EnsemblBacteria" id="ARF80508">
        <property type="protein sequence ID" value="ARF80508"/>
        <property type="gene ID" value="B6264_17770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33404">
        <property type="protein sequence ID" value="OEV33404"/>
        <property type="gene ID" value="HS99_0012545"/>
    </dbReference>
    <dbReference type="OMA" id="ARYHEEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="16837" checksum="CEECD79AE11222F1" modified="2017-01-18" version="1">MDTQPTEVATPQSDEITREVVDLMANLVALFHREYEEAAAARSLTGAQAKVLALLRRGPLPMRHIAQTLSCEPSNITGIVDRLEARGFVTREADRQDRRVKLVAATETGSAASEELRESLNFAREPLAALGPEERTMLRDLLRRMLTGASGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA6</accession>
    <name>A0A1E7MYA6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287538.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3958"/>
    <dbReference type="EnsemblBacteria" id="ARF80530">
        <property type="protein sequence ID" value="ARF80530"/>
        <property type="gene ID" value="B6264_17885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33425">
        <property type="protein sequence ID" value="OEV33425"/>
        <property type="gene ID" value="HS99_0012660"/>
    </dbReference>
    <dbReference type="OMA" id="VGKDWSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15734" checksum="CA91F1B47E8BE2A0" modified="2017-01-18" version="1">MSATADPADKSNPATRLGFEEGQIVQELGYDDDTDQDLREGIEEITGTDLVDEDYDDVADAVLLWHRDDDGDLTDALVDALEYLAEGGLIWLLTPKTGRDGHIEASDIADAAKTAGLSQTSSIAIAKDWAATRLATKSTAKQPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB9</accession>
    <name>A0A1E7MYB9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737967.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6565"/>
    <dbReference type="EnsemblBacteria" id="ARF80537">
        <property type="protein sequence ID" value="ARF80537"/>
        <property type="gene ID" value="B6264_17920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33432">
        <property type="protein sequence ID" value="OEV33432"/>
        <property type="gene ID" value="HS99_0012695"/>
    </dbReference>
    <dbReference type="OMA" id="SVETAYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="43721" checksum="67A724558094D7F5" modified="2017-01-18" version="1">MTHVMAKGANIALPAAAVRAVLRWSATPGAPDVDASALLLGANGKVRSDADFVFYNQPRHPSGLVRHLPKQHTSGGAEIIDTVEVELAKLPVEVDRVVLAGSSEGGPFRAVPGLRLLLFDAASGEGAVPLAEFAIEDAESVTALVAAELYRRNGSWKLRAIGQGYTSGLIGLATDFGITVDDEAEEAAAAAAPAPASTSGPTGAVDPRATPLRDPRSEARPDARPEPGTFTLSPAVPHPQSHPQPPAQPTTAPAPANTGAAAATGPTTPPPAAPPTPPPPPTTPPTMTPPPVAPPTAPPNVPPAPPAPPTPHPGGYGYPQQQPGTGYGYPQQQPSTGYGYPQPAQPYPPQPQPGAGYGYPQPNPPIPSQQHPGSYGYPPQQLPGTGQQPPVPPQPSVSAQAPAQAPAPAPAPASEEFALPPQGPQFQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE6</accession>
    <name>A0A1E7MYE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288736.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6593"/>
    <dbReference type="EnsemblBacteria" id="ARF80560">
        <property type="protein sequence ID" value="ARF80560"/>
        <property type="gene ID" value="B6264_18065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33456">
        <property type="protein sequence ID" value="OEV33456"/>
        <property type="gene ID" value="HS99_0012845"/>
    </dbReference>
    <dbReference type="OMA" id="DVWVPPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24322" checksum="B80A9DDE9A7FBEA4" modified="2017-01-18" version="1">MIRVLLADDQLLVRAGFRALLDLQDDLTVVGEADDGEAAVRLARELVPDVVLMDVRMPRMDGLEATRRIAEDPALSSVRVVVLTTFELDEYVFEALRSGAAGFLVKDTEPADLLRAVRVAVAGDALLSPGVTRRLIGEFAARSKGPETAPEGLTDVSVLTEREREVLALVGMGLSNEEIARRLVVSPLTAKTHVSRAMVKLGARDRAQLVVLAYESGLVRPGWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYF9</accession>
    <name>A0A1E7MYF9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Kynureninase</fullName>
            <ecNumber evidence="1 2">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynU</name>
        <name evidence="4" type="ORF">HS99_0012945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>H2O + L-kynurenine = anthranilate + H(+) + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288691.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6614"/>
    <dbReference type="EnsemblBacteria" id="ARF80575">
        <property type="protein sequence ID" value="ARF80575"/>
        <property type="gene ID" value="B6264_18165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33472">
        <property type="protein sequence ID" value="OEV33472"/>
        <property type="gene ID" value="HS99_0012945"/>
    </dbReference>
    <dbReference type="OMA" id="TFPTDGY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="79"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="44270" checksum="91BD87821B28C4A8" modified="2017-01-18" version="1">MITREECAALDAADPLAAFRKEFTLPDGVIYLDGNSLGALPVRTPERVAQVVEQEWGRELIRSWNDAGWFEQPYRLGRRIAPLIGADPAEVVVCDTTSVNLFKVLSAALELRPGRRTVLGDAEAFPTDLYIAEGVTGQVEGGRSVLVHPEELDRHLDGDVAAVVLSHVDYRTGELLDMPGITARVQAAGALMIWDVCHSVGALPVELGAAKADFAVGCTYKYLNSGPGAPAFLYVAERHLAAGPRQPLSGWFGHARPFAFEPGYDPKPGIGRFLTSSPSLLGQAALGASLDVWERADLAAVRTKSLALTDLFVSLVEGLDGVEVVTPREHARRGSQVALRHADGYPVVQALIARGVIGDFRAPDLMRFGFTPLYLSYTEVWDAARQLAEVLASGEWREERFSRRGEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYK6</accession>
    <name>A0A1E7MYK6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional RNase H/acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549920.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000252.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5173"/>
    <dbReference type="EnsemblBacteria" id="ARF80604">
        <property type="protein sequence ID" value="ARF80604"/>
        <property type="gene ID" value="B6264_18345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33501">
        <property type="protein sequence ID" value="OEV33501"/>
        <property type="gene ID" value="HS99_0013125"/>
    </dbReference>
    <dbReference type="OMA" id="GRWQIKH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="41351" checksum="D0C2D1C88EC37F11" modified="2017-01-18" version="1">MAARFIVEADGGSRGNPGPAGYGAVVRDGDTGQLVAEAAEFIGHATNNVAEYRGLIAGLRAARELDPDASVDVRMDSKLVVEQMSGRWKIKHPDMQPLAAEARTLFPRGRVTYTWIPRERNKDADRLANEAMDAGRDGRQWEPRKPAAPVDAAAALTAEPLGKSVSKAGWAAPADLGTPTTFVLLRHGETPLTPEKRFSGSGGSDPELSDKGRWQAERAAEALAARGSIQAVVASPMRRTRQTAEIVAARLGLEVRYEEGLREVDFGAWEGLTFAEVRERYPDDLTAWLGSAKARPTGSSESFTTLTHRVGVARDKVLARYPGRTVLVVSHVSPIKTLVRLALGAPPDSMYRMELAAASICAVQYYADGNASLRLLNDSSHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA9</accession>
    <name>A0A1E7MZA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0037830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553321.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3774"/>
    <dbReference type="EnsemblBacteria" id="ARF78400">
        <property type="protein sequence ID" value="ARF78400"/>
        <property type="gene ID" value="B6264_05225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33772">
        <property type="protein sequence ID" value="OEV33772"/>
        <property type="gene ID" value="HS99_0037830"/>
    </dbReference>
    <dbReference type="OMA" id="AMEELFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="43748" checksum="93433A48CAC12E71" modified="2017-01-18" version="1">MSSTFSLDPGADQLAVRDWLHGFAADVIRPAAAEWDEREETPWPIIQEAAKLGIYSLDFYAQQYFDPSGVGIPIAMEELFWGDAGIGLSIVGTTLAAVAVLANGTDEQIGTWTPQMFGTPDDVKVAAFCSSEPDAGSDVGALRTRAVYDEAKDEWVLNGTKTWATNGGIAAVHVVVASVDPELGTRGHASFVVPPGTPGLSQGQKFRKHGIRASHTAEVVLDGVRVPGSCLLGGKEKLDERLARAREGAKRAGGKGNAAMATFEASRPAVGAQAIGIARAAYEVALDYARTREQFGRPIIDNQGVAFQLADMKTRIDAARLLVWRASWMAVNNQPFTSAEGSMSKLYAGETAKFVTAQAMQILGGNGFTREYPVERMHRDSAIYSIFEGTSEIQRLVIARAISGMPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD3</accession>
    <name>A0A1E7MZD3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="7" type="ORF">HS99_0037640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283722.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4523"/>
    <dbReference type="EnsemblBacteria" id="ARF80381">
        <property type="protein sequence ID" value="ARF80381"/>
        <property type="gene ID" value="B6264_17015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33802">
        <property type="protein sequence ID" value="OEV33802"/>
        <property type="gene ID" value="HS99_0037640"/>
    </dbReference>
    <dbReference type="OMA" id="RCSHRPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14542" checksum="FD85F91D15C871C1" modified="2017-01-18" version="1">MIVVDASALVLALADQGPRGDRARAELAADGDWLAPEHIVIEVMQSLRGLYLAKQLTAERVAELTGELAAVTVRKVEVAPLLGRIWELKDNLTPDDAAYVAVAERYGAPLVTADLRLMRASGPRCEIRGIAREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ2</accession>
    <name>A0A1E7MZJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385372.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4394"/>
    <dbReference type="EnsemblBacteria" id="ARF82872">
        <property type="protein sequence ID" value="ARF82872"/>
        <property type="gene ID" value="B6264_16610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33847">
        <property type="protein sequence ID" value="OEV33847"/>
        <property type="gene ID" value="HS99_0037560"/>
    </dbReference>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="23386" checksum="2BC6CC53D9068585" modified="2017-01-18" version="1">MSATPEPTTRPYLTIRRAGSHETEIKKSRFICHLARVSDEDEAQAFIAGIRKQYWDARHNCTAFVVGDDQRRERSSDDGEPGGTAGVPMLEVLRRRGLTDTVAVVTRYFGGIKLGAGGLVRAYGNAVSEAVDEVGLLERRPVALLAVTADHVRAGRVENDLRAAGYAVSDLAYEAAGVRIEVGVPEPEVAGFHTWLAEATGGTAVAVPAGRTYVEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK9</accession>
    <name>A0A1E7MZK9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551292.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6366"/>
    <dbReference type="EnsemblBacteria" id="ARF78759">
        <property type="protein sequence ID" value="ARF78759"/>
        <property type="gene ID" value="B6264_07365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33864">
        <property type="protein sequence ID" value="OEV33864"/>
        <property type="gene ID" value="HS99_0037280"/>
    </dbReference>
    <dbReference type="OMA" id="NWAPSAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="517" mass="53405" checksum="5D4C522828F266E7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM0</accession>
    <name>A0A1E7MZM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectoine/hydroxyectoine ABC transporter ATP-binding protein EhuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282169.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6383"/>
    <dbReference type="EnsemblBacteria" id="OEV33890">
        <property type="protein sequence ID" value="OEV33890"/>
        <property type="gene ID" value="HS99_0037365"/>
    </dbReference>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="27579" checksum="BA5D2E795109C7CD" modified="2017-01-18" version="1">MVRAENVHKSYGPVEVLKGIDLEVRQGEVFCLIGPSGSGKSTFLRCINHLEKINGGRLWVDGELVGYQQRGDKLHELKDREVALKRRDIGMVFQRFNLFPHMTAMENVIEAPVQVKGETKAAARERGMALLERVGLADKAGNYPSQLSGGQQQRVAIARALAMKPKLMLFDEPTSALDPELVGDVLDVMRGLAEEGMTMVVVTHEMGFAREVGDALVFMDGGVVVESGNPREVLTNPQHERTRAFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZT1</accession>
    <name>A0A1E7MZT1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1884"/>
    <dbReference type="EnsemblBacteria" id="ARF77787">
        <property type="protein sequence ID" value="ARF77787"/>
        <property type="gene ID" value="B6264_01570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33935">
        <property type="protein sequence ID" value="OEV33935"/>
        <property type="gene ID" value="HS99_0010730"/>
    </dbReference>
    <dbReference type="OMA" id="RTVVWLE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="44267" checksum="5E5105B776F03EFF" modified="2017-01-18" version="1">MTAFRIRGRVTTILAPLVAGANYARLLHLLVGWIFAGVILMIYPGTYRKGLGEILTNAVSLDVVLLALVALIPAARRAEGVQARLLLVPDREEDIGVEPSGTWADRRRTAGWLIGRVVLGSTVGFATVFGLTPVFDLLTGPRALRYLPLVPVLALGYGWLVVWAGRLQLAMAVRLLGPSPADRLAEAELRAERLLERNRLARELHDSIGHALTVTVLQAGAAREIADPAFAAKALEVIEETGRQAMEDLERTLVLLRETPAGGPSAGGTSAGRTSGSGAATEQPGIDQLPALFDTARAAGCPVEANIEVPAGALPGVLSRESYRIVQEGVTNALKYAPGQPVDVQVAVREGQLELRCANRLVAAPGRAGAGRKGGKGLRGIRERAVLLGGAASAGPAESPGPSAEGGGEWVLDVRLPLRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW1</accession>
    <name>A0A1E7MZW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388026.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2189"/>
    <dbReference type="EnsemblBacteria" id="ARF77821">
        <property type="protein sequence ID" value="ARF77821"/>
        <property type="gene ID" value="B6264_01765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33965">
        <property type="protein sequence ID" value="OEV33965"/>
        <property type="gene ID" value="HS99_0010920"/>
    </dbReference>
    <dbReference type="OMA" id="TTHAQHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="31639" checksum="2996387E3371E7A7" modified="2017-01-18" version="1">MSAAQWPRPRVLVVGIDGVRHDFLAQVPMPRLREVAEAGFLVPVTVAETTPTMSGPCWATIVTGVEPAKHGVWGNHLGGNRLDVFPDFATRLNRGDRRRTFVAAGWDPLMINESGGPLFRAPGRLSYIAPAEDTPEAWETVDEEVTREAVHVLGTADPEASFVYLGAVDETAHFLGCGEEYRAAMRTADERLGRLLDAVRGRATHAEEQWTVIVVTDHGHVDAGGHGGRTVEERTAWVACAGHDIPASPPTGDIRHPDVAAQVYASLLRPIDPHWTLDGRPFPVARPVPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N010</accession>
    <name>A0A1E7N010_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280166.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2255"/>
    <dbReference type="EnsemblBacteria" id="ARF77871">
        <property type="protein sequence ID" value="ARF77871"/>
        <property type="gene ID" value="B6264_02080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34016">
        <property type="protein sequence ID" value="OEV34016"/>
        <property type="gene ID" value="HS99_0011235"/>
    </dbReference>
    <dbReference type="OMA" id="FEWKLYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="28272" checksum="207598AC55D6DE52" modified="2017-01-18" version="1">MDRDHVLALFDQRIRRDAQPDGPGVRVERDGAVVRQVGGERAWNGIVWSALDEAGADAAIAAQVSHFTELGLEFEWKTYAHDRPADLGRRLLAAGFTAEPDEALMIARIEDLHTDPVLPEGVRLESVADPAGVDLVVAAHEQAFERHMPGLRERILDHLRHSSDTISLVVAMAGDQPVSAARMELTPGTGFAGLWGGGTVPAWRGRGIYRALVAHRARLAAELGYEYLQVDASDQSRPILERLGFARLSTTTPYVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N067</accession>
    <name>A0A1E7N067_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551290.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6365"/>
    <dbReference type="EnsemblBacteria" id="ARF78760">
        <property type="protein sequence ID" value="ARF78760"/>
        <property type="gene ID" value="B6264_07370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33863">
        <property type="protein sequence ID" value="OEV33863"/>
        <property type="gene ID" value="HS99_0037275"/>
    </dbReference>
    <dbReference type="OMA" id="TAWNEFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="30634" checksum="026851FC6B64FEE1" modified="2017-01-18" version="1">MRRSLFGRTWPNVIAVVLIVFFVFPVYWMIATAFKQDRDIISKTPVFIPFDATFDHFGTAVDAPDFWTYVTNSVTVTVGAVVISLVIATLAAFAVARMKFRGRKAFVLVIMMAQMAPWEVMTIAVYMISRDNDMLNSLLPLTLFYMMMVLPFTIWTLRGFIAAVPKELEESAMVDGCTRTQAFVKVIFPLLAPGLMSTSLFGFITAWNEFPLVLIVNKEQGKTLPLWLSSFKTAFGNDWGATMAASTMFAIPVLILFVFLQRKAVGGLTDGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A4</accession>
    <name>A0A1E7N0A4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0011770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289990.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2367"/>
    <dbReference type="EnsemblBacteria" id="ARF77966">
        <property type="protein sequence ID" value="ARF77966"/>
        <property type="gene ID" value="B6264_02625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34106">
        <property type="protein sequence ID" value="OEV34106"/>
        <property type="gene ID" value="HS99_0011770"/>
    </dbReference>
    <dbReference type="OMA" id="YWKDKFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0050">Antiport</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0915">Sodium</keyword>
    <keyword evidence="1" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="2">
        <location>
            <begin position="8"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="517" mass="54053" checksum="6655385CF683BE69" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A9</accession>
    <name>A0A1E7N0A9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557265.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000459.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3700"/>
    <dbReference type="EnsemblBacteria" id="ARF77975">
        <property type="protein sequence ID" value="ARF77975"/>
        <property type="gene ID" value="B6264_02670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34114">
        <property type="protein sequence ID" value="OEV34114"/>
        <property type="gene ID" value="HS99_0011815"/>
    </dbReference>
    <dbReference type="OMA" id="WSWTESE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="28175" checksum="8E00B7723EB4829D" modified="2017-01-18" version="1">MSDAVLSARTALVTGASSGIGWETARLLAGHGATVLVHARTTAEAEAAVERLVAAGARRDQLVELAADFTKLSEVAVLAGTVVERYPSLDLLVNNAAATAPERCTLTDDGNEVSLQVNFLAAHLLSKLLRAPLSAAGDARIVNVSSSLHRTASMNWSDPHRVKKYSRVAAYAQSQLALTMATADMAPAGSGVTAVSVNPGLCDTALLPLYGRVGAPAAEGAAAVVRLCLPETVVANGAYFDGEVIASPAPVTQEERSLKRLAKLADQLVGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0C2</accession>
    <name>A0A1E7N0C2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557294.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3724"/>
    <dbReference type="EnsemblBacteria" id="ARF77996">
        <property type="protein sequence ID" value="ARF77996"/>
        <property type="gene ID" value="B6264_02790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34132">
        <property type="protein sequence ID" value="OEV34132"/>
        <property type="gene ID" value="HS99_0011935"/>
    </dbReference>
    <dbReference type="OMA" id="WTRTRER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="22873" checksum="C81CF1A657D6F0AB" modified="2017-01-18" version="1">MVGRQQRAVRTRELILEAAAEVFDESGFAGGSITRITERAATTQGAIYFHFKSKEGLARAVIMYQAAHLEGLPQKPGGLQQLIDLTFYLAHELQRNVVFRAGVRLAVEQGEAGLSEYSIYQEWIERFRAELTVARAAGELLPDAEEGVFAAVLVAGFTGSQVMSQIASGRADLPERIASLWRCLLPGIAMPGARDALVLDAERHRGWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0K0</accession>
    <name>A0A1E7N0K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554568.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6043"/>
    <dbReference type="EnsemblBacteria" id="ARF78136">
        <property type="protein sequence ID" value="ARF78136"/>
        <property type="gene ID" value="B6264_03705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34220">
        <property type="protein sequence ID" value="OEV34220"/>
        <property type="gene ID" value="HS99_0036805"/>
    </dbReference>
    <dbReference type="OMA" id="SAVWRVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="653" mass="66558" checksum="481AD5C56B2B6D62" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N6</accession>
    <name>A0A1E7N0N6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366519.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6076"/>
    <dbReference type="EnsemblBacteria" id="ARF78166">
        <property type="protein sequence ID" value="ARF78166"/>
        <property type="gene ID" value="B6264_03865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34249">
        <property type="protein sequence ID" value="OEV34249"/>
        <property type="gene ID" value="HS99_0036965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="23319" checksum="06A0F9475E5C6387" modified="2017-01-18" version="1">MRRTVVNRVLLGLVGSVLLGFGVLVLAGGLDLYRRLGVHPPGWWPLTSPDQPVLSARSRRRWVESSWWWPTVIGALAVLVAGMAWWLVAQLRRTGLHRIDVPTPGAGGLRLKVSARALEEALEHGTSVLPEVERARVRLVRAPGHPRLRGAVRLTPGGDPVGLVEHFEDGPRVDAVRSLGLAELPADLRIRVREAPAERRRGRRRHRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q5</accession>
    <name>A0A1E7N0Q5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386498.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2597"/>
    <dbReference type="EnsemblBacteria" id="OEV34269">
        <property type="protein sequence ID" value="OEV34269"/>
        <property type="gene ID" value="HS99_0036705"/>
    </dbReference>
    <dbReference type="OMA" id="WIDQLYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="17706" checksum="0C9927BB0058C49C" modified="2017-01-18" version="1">MWMQSDAPFTGNVHLRAARAEDAAAVTEVFLASRAAAMPYLPRLHSDEATLWWVTNVVLADTRVWLAEDAGTGALLGFAALDGALLDHLYLRPDVRRRGIGTLLLGAVKEASPEELSLHVFQRNTGARAFYERHGFVPVDSNDGSRNEENEPDLTYRWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1E0</accession>
    <name>A0A1E7N1E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7068"/>
    <dbReference type="EnsemblBacteria" id="OEV34494">
        <property type="protein sequence ID" value="OEV34494"/>
        <property type="gene ID" value="HS99_0035440"/>
    </dbReference>
    <dbReference type="OMA" id="NWDFFSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="349" mass="37405" checksum="8E8DBBB286E404FB" modified="2017-01-18" version="1">MTGRLLLEGTAFERGEQHGRSLAGELRAFLDDGLARLNHLTATPLTLDGLRPRIDAYRAAVEAATPDLAAEVEGLAAGAGLSPAEAWLLQLRREIMGYQKVPTAGDCTTYARAGGRYTGHPVLAQTVDLNGNLDDAISVLDVAPAGSARRSLVLSFAGLLGYLGLNSDGLAIGINLVLGGDWRPGLPPYLAIRHLLDTADSVTRALELLRGMRLASSRSLTLCDRERAVCVEVLGDELRVREGYQTAHTNHFLDPDLARGDELNVFARNSSVRRLKEAEAGLAELDPAAGPEEHFALLSRPPICVPDEGDIRRERTVAAVVLLPGRGELHLRPGDPSRSATQVFGLRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V5</accession>
    <name>A0A1E7N1V5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000466.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4219"/>
    <dbReference type="EnsemblBacteria" id="ARF81968">
        <property type="protein sequence ID" value="ARF81968"/>
        <property type="gene ID" value="B6264_26530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34667">
        <property type="protein sequence ID" value="OEV34667"/>
        <property type="gene ID" value="HS99_0009245"/>
    </dbReference>
    <dbReference type="OMA" id="GHYAIVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20237" checksum="706BD2EED7E7289B" modified="2017-01-18" version="1">MKATRRVRAIGLCALAVSATMLAAGSTPAAASVAPLFRAKLMANHSGKCLDVPFASQADGQPVQQWHCYDAPDNQTWNFVAAYNSDLGAGFLADNYYTVRAQHSGKCLEVQGGSTADGASVVQQTCDTSYQTTQQQWKLVQRPDGYFSLVARHSGKCLTVPQGILGDGIYVVQQGCSNDLPYQEWKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W1</accession>
    <name>A0A1E7N1W1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34655">
        <property type="protein sequence ID" value="OEV34655"/>
        <property type="gene ID" value="HS99_0009165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198677" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="18635" checksum="4433E39FAA684645" modified="2017-01-18" version="1">MTRLAVLLGLMTALLGTSVEPASAAPGDLISPITIVNSATSGHLLPWGFGDDHDDNIWMVAANSATRGDQWTLEELQGGYYLIRNNATGKCLKPAPFTYFGKTYVTQASCNDSFEFQWELAHSVFTNLYKIVNRSTRQAMTPYQNLPDQVVVLDTNSNDAKNWWSLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y1</accession>
    <name>A0A1E7N1Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558280.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000535.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000104_gene7214"/>
    <dbReference type="EnsemblBacteria" id="ARF81955">
        <property type="protein sequence ID" value="ARF81955"/>
        <property type="gene ID" value="B6264_26445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34681">
        <property type="protein sequence ID" value="OEV34681"/>
        <property type="gene ID" value="HS99_0009335"/>
    </dbReference>
    <dbReference type="OMA" id="IVYETHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="20504" checksum="F3D95D0984C0E739" modified="2017-01-18" version="1">MAVEIVYETHATTTDNEAGIATGWLPGRLSELGRLQAAELGERRRAGGFAAVFTSDLHRAVETARIAFPNGRPPIHQDIRLRECNYGDLNGTPVSRIAAQRARRIDEPFPGGQSYRQVLAATDVFLHDLATRWDGGRILVIAHSANRWALDCLLTGASMKELVEAPPAWRPGWHYVLPAGWTPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2B0</accession>
    <name>A0A1E7N2B0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556964.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3214"/>
    <dbReference type="EnsemblBacteria" id="ARF81825">
        <property type="protein sequence ID" value="ARF81825"/>
        <property type="gene ID" value="B6264_25640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34815">
        <property type="protein sequence ID" value="OEV34815"/>
        <property type="gene ID" value="HS99_0010105"/>
    </dbReference>
    <dbReference type="OMA" id="REFVEYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="28973" checksum="CC6A6E768137CCE6" modified="2017-01-18" version="1">MTPTTSAAGTAPKTYAWEIHASGLRVRVGRRKTAVDGLDLSLGIGTHGLLGPNGAGKTTLIRTLATVLRPTEGELEMLGTRVGAMVDHRSLRRQIGYLPQEFGYYKRFTVREFVEYMAWLKEVPKADVPAAVQRAVERVGLADRADHRMKTLSGGMVRRAGIAQAIVNDPAVLLLDEPTVGLDPAQRLRFRELLQELGRDTCVVVSTHLVEDVAAACSDVVLLAEGRLVFQGTPDDLAAAGGPEHPGDSPLERGYSALLQGCEQPGGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D4</accession>
    <name>A0A1E7N2D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557748.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7612"/>
    <dbReference type="EnsemblBacteria" id="ARF81791">
        <property type="protein sequence ID" value="ARF81791"/>
        <property type="gene ID" value="B6264_25425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34847">
        <property type="protein sequence ID" value="OEV34847"/>
        <property type="gene ID" value="HS99_0010295"/>
    </dbReference>
    <dbReference type="OMA" id="VLPAERH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7201" checksum="F27C0D5DF1DAC7CA" modified="2017-01-18" version="1">MSAAELTPPEAARWAARAGLVLPAERHAAVAAVADHIHSVVAVLRELDFADVPPAAAYRAAEEHHDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2P8</accession>
    <name>A0A1E7N2P8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="6" type="ORF">HS99_0034745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557940.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4574"/>
    <dbReference type="EnsemblBacteria" id="ARF78526">
        <property type="protein sequence ID" value="ARF78526"/>
        <property type="gene ID" value="B6264_06015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34971">
        <property type="protein sequence ID" value="OEV34971"/>
        <property type="gene ID" value="HS99_0034745"/>
    </dbReference>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="31393" checksum="5A744969FCBD9F90" modified="2017-01-18" version="1">MAVVTMRELLESGVHFGHQTRRWNPKMKRFIITERNGIYIIDLLQSLNYIDRAFEFIKETVAHGGSVLFVGTKKQAQEAIAEQATRVGMPYVNQRWLGGMLTNFSTVYKRLQRLKELGELDFSDVAGSGLTKKELLVLQREHDKLEKTLGGIRDMQRVPSAVWIVDTKKEHIAVGEARKLNIPVVAILDTNCDPDEVDYKIPGNDDAIRSVTLLTRVIADAVAEGLKARAGVAKGDAKAEPGADQPLADWEKDLIEGEKKAEEAAPAAAEAPAAEAPAAEAPAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3K5</accession>
    <name>A0A1E7N3K5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366818.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5303"/>
    <dbReference type="EnsemblBacteria" id="ARF80715">
        <property type="protein sequence ID" value="ARF80715"/>
        <property type="gene ID" value="B6264_18990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35289">
        <property type="protein sequence ID" value="OEV35289"/>
        <property type="gene ID" value="HS99_0033050"/>
    </dbReference>
    <dbReference type="OMA" id="LACRMIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="388" mass="40870" checksum="7530D7BAA01A20BD" modified="2017-01-18" version="1">MLSRRGALLLAAGGLAQLSLPPAAPAALPDERAADRHAEVAGLLAARARSLPVRSGLTGAEAAYRNLVLSPGRGAPTADGPERLTASVELAVRIAGYDEYPVVYPRRIELVRDRDGWRVEHEEGTDGPPALWDLGPARTAPGARCLVLGLAGGPDPAGLVAVGDQAVPAVSAVWGSGWPGRLLLELPATEAQFARLLEADPASWTGMAAVTVAAPGAPWHTPADRVVINPEAFGRLSDFGRQVVVTHEATHVATRADTRAWTPLWLSEGVADWTAYRESGRRPQQIAPELTRDVVAGRLPTALPADGDFAAGATGIAQAYEQAWLACALIAGRYGTDRLVAFYRAVGAADGQGEDRDRRTDRLLRGELGVGLAEFTALWLAEVQALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3K8</accession>
    <name>A0A1E7N3K8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0033455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1359"/>
    <dbReference type="EnsemblBacteria" id="OEV35255">
        <property type="protein sequence ID" value="OEV35255"/>
        <property type="gene ID" value="HS99_0033455"/>
    </dbReference>
    <dbReference type="OMA" id="LEPDFWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198720" evidence="2">
        <location>
            <begin position="17"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="575" mass="61455" checksum="136B98BE2C30B795" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q3</accession>
    <name>A0A1E7N3Q3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(Fe-S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550014.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000321.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5319"/>
    <dbReference type="EnsemblBacteria" id="ARF80727">
        <property type="protein sequence ID" value="ARF80727"/>
        <property type="gene ID" value="B6264_19070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35302">
        <property type="protein sequence ID" value="OEV35302"/>
        <property type="gene ID" value="HS99_0033130"/>
    </dbReference>
    <dbReference type="OMA" id="YVCMCHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="10332" checksum="04B9A2EA56832820" modified="2017-01-18" version="1">MYVCMCHAVTEDQVKEAIDGGAGTPRQIAKGCKAGTDCGSCVRRIQALLGEHGARPCPTARLAAKLGLADPQVQDVPAPAAPKPGPTAPLGPVAPVVPLRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R0</accession>
    <name>A0A1E7N3R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550016.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000321.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5321"/>
    <dbReference type="EnsemblBacteria" id="ARF80729">
        <property type="protein sequence ID" value="ARF80729"/>
        <property type="gene ID" value="B6264_19080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35304">
        <property type="protein sequence ID" value="OEV35304"/>
        <property type="gene ID" value="HS99_0033140"/>
    </dbReference>
    <dbReference type="OMA" id="VVPHLYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="23594" checksum="6629846539F7B9EE" modified="2017-01-18" version="1">MGQSEREPLPPSDPRLPPGQRVQRGWPALHYGPVPRFKPLTWDLQVFGATASAEKHSWDFEAFNALPRTTVVGDLHCVTKFSVLGNEWTGVSAALLLDLVPPAPGVTHVMVWAEYGYSANLRLADFADGRTLLATHRNGEALTAEHGFPVRLVVPELYAWKGPKWVRAVEYMRADRRGFWEERGYHNLADPWCEQRHSYQEEPGDGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y0</accession>
    <name>A0A1E7N3Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2443"/>
    <dbReference type="EnsemblBacteria" id="OEV35399">
        <property type="protein sequence ID" value="OEV35399"/>
        <property type="gene ID" value="HS99_0032480"/>
    </dbReference>
    <dbReference type="OMA" id="DIVAHHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="281"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="40567" checksum="DD935E2C6A339103" modified="2017-01-18" version="1">MSWSRPDALVAIGAGAIDLLGYLFLGEVAGARGLTVPGLALIVLSALPLLARHSRPVPVLAAVLVLQAAIDLTAPIGPHFGAVLTVALFSVGRSRSVPVTLAAVVLTAAATTLSQVGFHAPLWQQVVADPLSAVLVGCAGLVVARWQREVDANRRLQADRAVAEERRRIARELHDIVAHHITTMQLMAGGARANLDRPEVVRDALVTLESSGRLALREMRQLLNVLRAGDEPESVPPLPQPGADEVVRLVDESCLAGLPTELTVDGPRRPLPPTVGLTVFRIVQEGLTNARKYAGPARASVRLAYHPDRITVEVRDDGGGTPPERAPGTGPAGYGLLGMRERVALHGGTLTAGPRPEGGFAVRAELPLSCDESAEAAVQHGQEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y1</accession>
    <name>A0A1E7N3Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278624.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000871.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2383"/>
    <dbReference type="EnsemblBacteria" id="OEV35385">
        <property type="protein sequence ID" value="OEV35385"/>
        <property type="gene ID" value="HS99_0032780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12912" checksum="85207B641D959FBF" modified="2017-01-18" version="1">MDRKEPVEQPQGPLTAFGGRLALDPDARTATVDGRAVPLTYQDVRGLRTLIELGEGLHDARDVLLYGWGAWTDPRELRYPMAVLRAKLGEPWWIVRDGDRYGLRPPGPPPSGRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F9</accession>
    <name>A0A1E7N4F9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278703.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2424"/>
    <dbReference type="EnsemblBacteria" id="OEV35353">
        <property type="protein sequence ID" value="OEV35353"/>
        <property type="gene ID" value="HS99_0032575"/>
    </dbReference>
    <dbReference type="OMA" id="LWDIGPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="31066" checksum="200711B2B43A5BB2" modified="2017-01-18" version="1">MRIGLLGTGTWAERVHAPVLAEHPGLEFTGVWGRRPEAAEALGVAHGVPGYGDLDRLLAEVDAVSVALPPSVQAGLAVRAAEAGRHLLLDKPVAFTVPDARAVAEAVRAHEVASVVFFTVRFGGEQIPWIERQAELGGWFTGRSDWLGSVFAPGSTSPYAASPWRREKGALWDVGPHALSVLLPVLGDATQVTAVAGPLDTVHLVVRHVGGASSTMALSLTVPRAGGGAVMELRGEHGVAQLPERGEAPTVALHRAVDALLASAASGEPHPCAADFGLRVVEILAGAERSLADGRPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B9</accession>
    <name>A0A1E7N5B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286215.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7270"/>
    <dbReference type="EnsemblBacteria" id="ARF81101">
        <property type="protein sequence ID" value="ARF81101"/>
        <property type="gene ID" value="B6264_21285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35890">
        <property type="protein sequence ID" value="OEV35890"/>
        <property type="gene ID" value="HS99_0008510"/>
    </dbReference>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="28077" checksum="B258E9A773290E53" modified="2017-01-18" version="1">MSASPRSDNDVVCRRLVGRTAVVTGAGSGIGLAAARRLASEGAKVVCADLDEQTGRAAAKEVGGLFVHTDVTDPYMVEALFDEAYETYGSVDVAFNNAGISPPEDDSILTTGLDAWRKVQDVNLTSVYLCCKAALPYMRRHGRGSIINTASFVARMGAATSQISYTASKGGVLAMSRELGVQFAREGIRVNALSPGPVDTPLLRELFAEDPERAARRLVHIPLGRFARAEEIAAAVAFLASDDSSFITASEFLVDGGISGAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F9</accession>
    <name>A0A1E7N5F9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="6" type="ORF">HS99_0008670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000381.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7302"/>
    <dbReference type="EnsemblBacteria" id="ARF81131">
        <property type="protein sequence ID" value="ARF81131"/>
        <property type="gene ID" value="B6264_21445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35919">
        <property type="protein sequence ID" value="OEV35919"/>
        <property type="gene ID" value="HS99_0008670"/>
    </dbReference>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="50797" checksum="3275C78782A2D33A" modified="2017-01-18" version="1">MTAQQSSDVRLWGARFADGPSEALARLSASVHFDWRLAPYDIAGSRAHARVLHRAGLLSDEELSGMLAGLDQLLTDVRSGAFVGTVADEDVHTALERGLLERLGADLGGKLRAGRSRNDQIATLFRMYLRDHARTIGGLLLDLQHALVGLAEAHPDTAMPGRTHLQHAQPVLFAHHVLAHVQALGRDAERLRQWDARTAVSPYGSGALAGSSLGLDPEAVAADLGFEGGSVGNSIDGTASRDFVAEFAFVTAMIGVNLSRIAEEVIIWNTKEFGFITLHDAFSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSCDTLEVLLPAFTGMMATLTVHRERLEELAPAGFSLATDIAEWLVKQGVPFRVAHEVAGACVKVCEAEGIELGDLTDERFASISEHLTPEVRSVLSVHGAIAARNGRGGTAPSAVAVQLAEVKADLARQQEWVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L8</accession>
    <name>A0A1E7N5L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7268"/>
    <dbReference type="EnsemblBacteria" id="ARF82980">
        <property type="protein sequence ID" value="ARF82980"/>
        <property type="gene ID" value="B6264_21275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35997">
        <property type="protein sequence ID" value="OEV35997"/>
        <property type="gene ID" value="HS99_0008500"/>
    </dbReference>
    <dbReference type="OMA" id="NPGQHEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="50569" checksum="B5A6BB50BD6B165E" modified="2017-01-18" version="1">MPENAAAGSRPRPPLTLAELRTLVDAGEVHTVALAFTDMQGRLQGKRFAARFFLDEVAQNGAEACDYLLAVDVDLNTVDGYAFSSWATGYGDFAMRPDLGTLRLTPWQPGTAQVTADLARHGGHPVDAAPRQLLRRQIARLAEYGLAADIGTELEFLVFRDTYEQAWLGGYRGLTPANLYNVDYSMLGTARVEPLLSRIRNEMAGAGLTVESAKGECNLGQHEIAFRYADALTTCDQHSVYKTGAKEIAAQQGCALTFMAKYDEREGNSCHIHLSLRDAVGAPAFADRDGRMTDTMRHFLAGQLVALREFSLLYAPNINSYKRYRPGSFAPTAVAWGRDNRTCAYRVVGHGPGLRMENRVPGGDVNPYLAVAGMIAAGLHGLQRKLDLPTPCLGNAYAVEEYARVPGSLREAAELWAGSELARTAFGDDVVEHYLNMARVEQAAYDGAVTDWERYRSFERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5P7</accession>
    <name>A0A1E7N5P7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0031460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554408.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000230.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene512"/>
    <dbReference type="EnsemblBacteria" id="ARF78808">
        <property type="protein sequence ID" value="ARF78808"/>
        <property type="gene ID" value="B6264_07670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36027">
        <property type="protein sequence ID" value="OEV36027"/>
        <property type="gene ID" value="HS99_0031460"/>
    </dbReference>
    <dbReference type="OMA" id="SGFQCGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="956" mass="99593" checksum="910276DCF48CE6C5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G1</accession>
    <name>A0A1E7N6G1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283606.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36296">
        <property type="protein sequence ID" value="OEV36296"/>
        <property type="gene ID" value="HS99_0030275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="9013" checksum="EC0B4E84A6C2262B" modified="2017-01-18" version="1">MTTRDQNGTQPDEPTQERSAEERSITAPTPADVREKARGKVGDRERSAEERSITAPTPADVRRKGGTDGDDDEPEPPAADAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6K8</accession>
    <name>A0A1E7N6K8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">HS99_0030970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553160.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4970"/>
    <dbReference type="EnsemblBacteria" id="ARF80038">
        <property type="protein sequence ID" value="ARF80038"/>
        <property type="gene ID" value="B6264_14950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36093">
        <property type="protein sequence ID" value="OEV36093"/>
        <property type="gene ID" value="HS99_0030970"/>
    </dbReference>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="41895" checksum="F364FA96E343AD96" modified="2017-01-18" version="1">MEKQIPVTTAGTGPRIPTPEQIRRAPKVLLHDHLDGGLRPETVVELAAATGYEGLPTTDVKELGEWFREAADSGSLVRYLETFAHTCAVMQTREALAKVAADCAEDLAADGVVYAEVRYAPEQHLEGGLTLDEVVEAVQEGFRLGEANARAAGNRIRIGTLITAMRHAARSQEIAELANRHRDQGVVGFDIAGAEAGYPPTRHQAAFDYLKGENNHFTIHAGEAFGLPSIWEALQCCGADRLGHGVRIVDDITVNEDGSVELGRLAAYVRDKRIPLEMCPTSNLQTAAATSYAEHPIGLLSRLKFRVTVNTDNRLMSGTSMSQEFGHLVDAFGYTLGDMEWFTVNAMKSAFLPFDERLAMINDVIKPGYAELKAEWLFSVGTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X2</accession>
    <name>A0A1E7N6X2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7749"/>
    <dbReference type="EnsemblBacteria" id="ARF82316">
        <property type="protein sequence ID" value="ARF82316"/>
        <property type="gene ID" value="B6264_28650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36394">
        <property type="protein sequence ID" value="OEV36394"/>
        <property type="gene ID" value="HS99_0030015"/>
    </dbReference>
    <dbReference type="OMA" id="WANAGGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="36163" checksum="837D2EF6EFC24E2A" modified="2017-01-18" version="1">MSVRNRFGSAAAIALMTTVSAVLLSACGPDNADSGATAAPGTNASGSSAPGAAAPGTAAPGGATHTGSPAPGRKEVNGTTVANHLTISTGTRNVAMNGTIVDFGSVVRDLAWSPDGKKVVFVSDSGDLMTANPDGTGKATLAKHPDGEEWSHPTWQHADKGPSGDAVPNETERYNNIVFTAKKAGVLRLVKVPAKGGAVEDLSPHNSEGGDNPGVPQPPQTGNTWANAGGRQAAIAYANTPTNEVYIYDDYIRSGTQDIGKGSQPALSPDGGQIVFVRAVNGHDHLFTRSTDHDRKAEKDLTPSATTDFTEPAWSPDGKTVAARTPDGIDTVPADGSAAPTQVSTIPGLPVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Z2</accession>
    <name>A0A1E7N6Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289730.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene215"/>
    <dbReference type="EnsemblBacteria" id="ARF82250">
        <property type="protein sequence ID" value="ARF82250"/>
        <property type="gene ID" value="B6264_28250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36445">
        <property type="protein sequence ID" value="OEV36445"/>
        <property type="gene ID" value="HS99_0029355"/>
    </dbReference>
    <dbReference type="OMA" id="HESADCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="9638" checksum="A31365E3D2DB8F4B" modified="2017-01-18" version="1">MKFTLNAALGVPLMTAAVLALSTGPATAATGDLAINGTTRTDPSGCYALDGAASIVDNLTDEAAEIHSGADCTGDVLEVIQAGDDSRVTGAQSLFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G7</accession>
    <name>A0A1E7N7G7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385902.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2537"/>
    <dbReference type="EnsemblBacteria" id="OEV36647">
        <property type="protein sequence ID" value="OEV36647"/>
        <property type="gene ID" value="HS99_0028160"/>
    </dbReference>
    <dbReference type="OMA" id="SNDRMRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="217" mass="22632" checksum="811ED7EE05191BD0" modified="2017-01-18" version="1">MTSAAVDSAPKSVVKFLEPITRENAAVVLVDHQVGLLSGVRDIPLGELKHNVVALAKAATALDVPLVVTTTAAESMWGPTFPELVQALPTGQKIIDRSTVNAWHDGRVREAVEATRRQKLIFAGVSLEVCAALPAIAATAAGHDAYVAVDASGTFSRTKREAGLLRMQQAGVVVSDYATLMVEALADNAAPESGAVYAALDMPFAVLVGQISAAYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X5</accession>
    <name>A0A1E7N7X5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase C</fullName>
            <ecNumber evidence="2">3.1.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycerol + H(+) + phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:10604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10605"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial phospholipase C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553039.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000859.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4850"/>
    <dbReference type="EnsemblBacteria" id="ARF82411">
        <property type="protein sequence ID" value="ARF82411"/>
        <property type="gene ID" value="B6264_29215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36806">
        <property type="protein sequence ID" value="OEV36806"/>
        <property type="gene ID" value="HS99_0027795"/>
    </dbReference>
    <dbReference type="OMA" id="LPWYLGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034480">
        <property type="term" value="F:phosphatidylcholine phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017767">
        <property type="entry name" value="Bact_PC-PLC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03396">
        <property type="entry name" value="PC_PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="661" mass="72201" checksum="D3330DB84347D030" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N880</accession>
    <name>A0A1E7N880_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281977.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6478"/>
    <dbReference type="EnsemblBacteria" id="ARF78660">
        <property type="protein sequence ID" value="ARF78660"/>
        <property type="gene ID" value="B6264_06805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36892">
        <property type="protein sequence ID" value="OEV36892"/>
        <property type="gene ID" value="HS99_0026880"/>
    </dbReference>
    <dbReference type="OMA" id="CGVAIDS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="28"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="561" mass="62026" checksum="3788F600424EE826" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F5</accession>
    <name>A0A1E7N8F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284691.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4777"/>
    <dbReference type="EnsemblBacteria" id="OEV36753">
        <property type="protein sequence ID" value="OEV36753"/>
        <property type="gene ID" value="HS99_0027445"/>
    </dbReference>
    <dbReference type="OMA" id="SRQAWDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="50816" checksum="E5ECD9F9F1DD695C" modified="2017-01-18" version="1">MTSSETAPGRGTAVVIGGGLAGVVAAWALRGFAERIVVVERDRYPEEPAFRAGVPQGRHAHLVLEAGHRALEELMPGINQELTAAGAHRVSTSGDLKWLSSAGWMIDYPARMTFLSCTRPVLDKLVLDRVRTEPSIEFLEGTDVVGLLGSAQAVTGVKLRERGAGRGSEQETERDSAHDAAHDSEGGSERGSERGEVRDFPAELVIDASGRSTSVPKWLSELGCRPVPEERVDAGVAYASRLFHRPPGVDFGHQAIYLQTKAPDKPRMGVLLPVEGDRWIVSLAGMRGAEPEPGEAGFTKHLSQLRDPGLSEMLREAEPASEVRGFLPGPGVRRHYERSSPAGLVAVGDAASTFNPVYGQGVTISLFCAQVLRRTALRHGDIGPATARDARREIAAVSKNAWMMSCAEDVRFAATTGGPTGALIRLQHRYLDRVLHGATRNPEVTAAFHEVLSLVEPPTRLFHPSVVAAVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8I0</accession>
    <name>A0A1E7N8I0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene136"/>
    <dbReference type="EnsemblBacteria" id="OEV36991">
        <property type="protein sequence ID" value="OEV36991"/>
        <property type="gene ID" value="HS99_0003935"/>
    </dbReference>
    <dbReference type="OMA" id="AFVAHWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12479" checksum="CCDFACFE0A0C04FC" modified="2017-01-18" version="1">MSQPVHDGVELIPRPEQSPAALKAALAVVAADRLPEMIDGQTRAMAEAITTGSVQPIRAFVAHWATVVEIERHPATAQVYHRANYLANHAGTAQECREHAAVVAELYRAAYAAVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L5</accession>
    <name>A0A1E7N8L5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556172.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7465"/>
    <dbReference type="EnsemblBacteria" id="OEV37037">
        <property type="protein sequence ID" value="OEV37037"/>
        <property type="gene ID" value="HS99_0004205"/>
    </dbReference>
    <dbReference type="OMA" id="ALMLIDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="13049" checksum="950148A473A881F9" modified="2017-01-18" version="1">MSSAVITDPAQLPVVFQDALNSGDVDAVLALFAPGAAMRTVSGELVTGPGALRAEIGGTVAARGRLTNVQRHTLVGAGTALLVTDWTLEIDTPTGDRIAPTGTTANIARQDPSDGGWRFALLNPLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8P8</accession>
    <name>A0A1E7N8P8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7481"/>
    <dbReference type="EnsemblBacteria" id="OEV37024">
        <property type="protein sequence ID" value="OEV37024"/>
        <property type="gene ID" value="HS99_0004120"/>
    </dbReference>
    <dbReference type="OMA" id="WCAADSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028961">
        <property type="entry name" value="Imm21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15589">
        <property type="entry name" value="Imm21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21377" checksum="484BE2231588C656" modified="2017-01-18" version="1">MSTDPHAVRMTLDLTWVESMGGPLIVVPVSALQYWGGCTEDGMIIGESDQPDDYDRACGVEGLAEVIGLRGRSDVSALVLGDEPATTCYLPEQGAFVRWLAADSDAELLAAAEAALNDPATPWEECGLWETDGPAVLMDSAEAGKNLGVPYPDGRGEPDQAPVHLPAGRWRVRAFQKTGDSPWISVVQLLLQVDGQSTTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8V2</accession>
    <name>A0A1E7N8V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556100.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000736.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7424"/>
    <dbReference type="EnsemblBacteria" id="ARF81655">
        <property type="protein sequence ID" value="ARF81655"/>
        <property type="gene ID" value="B6264_24570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37074">
        <property type="protein sequence ID" value="OEV37074"/>
        <property type="gene ID" value="HS99_0004420"/>
    </dbReference>
    <dbReference type="OMA" id="MYEFHGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028965">
        <property type="entry name" value="Imm7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15585">
        <property type="entry name" value="Imm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="15417" checksum="AABED396F87B1412" modified="2017-01-18" version="1">MFEYHGWINVLETAGADDEDIRLEEGRLNVIAEGIQQRVEEIASPHLLDLRRMNGALFLHFGGQRNHRDPEVLDFFREVGRRAPGSYGLLHVRDDENPAHENEVYVLRMVRGEVSEHAEPMLSPCVPVLEDPLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W8</accession>
    <name>A0A1E7N8W8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81587">
        <property type="protein sequence ID" value="ARF81587"/>
        <property type="gene ID" value="B6264_24165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37146">
        <property type="protein sequence ID" value="OEV37146"/>
        <property type="gene ID" value="HS99_0004825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="19769" checksum="43DCD61306DA2D24" modified="2017-01-18" version="1">MDVNYPTQTSNQYEFQIRGFFREHPVFVVKAFDRHERAFPFAAARCVDDFYDDDHRHHEDGDRDDHARPHDGVAADGGGPSGAPSPEGGDQGHNGQPAPETSTSGGTSLSPPPGGETFGESIGRLGAKRIGIASGGLLMVLGALAAAWLRRRRRKRATRPEQGPAAPPTPDGASDQEPEVPPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y5</accession>
    <name>A0A1E7N8Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366170.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6224"/>
    <dbReference type="EnsemblBacteria" id="ARF81574">
        <property type="protein sequence ID" value="ARF81574"/>
        <property type="gene ID" value="B6264_24090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37160">
        <property type="protein sequence ID" value="OEV37160"/>
        <property type="gene ID" value="HS99_0004900"/>
    </dbReference>
    <dbReference type="OMA" id="ATICKPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22905" checksum="38B52DAB269CCABB" modified="2017-01-18" version="1">MDATIRGHQGFVIVMRYLKRRGPFCRTCGIATHREMTSDTLWQGWWGIPSMIVNPIVMLFNIPQRLKINKLAEPLPGAPGTPMDTGKPVYLRPTIVGLLIPAVLIALLFTLLKDDPEFAKAGDCVHNSSPLAMSGLNDNNPDVKVVPCSDPQADARVVGRADDTTDGEAECRKYPDADSYFTYKRGSDKYLLCLTSLKPRPKLTFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N929</accession>
    <name>A0A1E7N929_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556673.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81579">
        <property type="protein sequence ID" value="ARF81579"/>
        <property type="gene ID" value="B6264_24120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37154">
        <property type="protein sequence ID" value="OEV37154"/>
        <property type="gene ID" value="HS99_0004870"/>
    </dbReference>
    <dbReference type="OMA" id="VEWHYIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="12528" checksum="DC4047BA8E6F3AA4" modified="2017-01-18" version="1">MSSRGLAVPGAAVAALALAALFLPAAGAHAAPRADSCTNNWSISSAEGYANGKWCNYDTKVIGTVHDTKADGRCPYVRGDLSNGGHVDSDWAGGKGKSRSITLLAPSNSHFTSLSMRYINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G6</accession>
    <name>A0A1E7N9G6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556485.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5453"/>
    <dbReference type="EnsemblBacteria" id="OEV37340">
        <property type="protein sequence ID" value="OEV37340"/>
        <property type="gene ID" value="HS99_0006025"/>
    </dbReference>
    <dbReference type="OMA" id="EGQAMRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="39219" checksum="71EE0CD31C43509B" modified="2017-01-18" version="1">MRSTTNARIAVVGAGLGGLACARVLHRHGRSVTVFERENSADARPQGGSLDIHSGTGQVALRAAGLLDGFRALARPESQEWRILDPATAAVLPVPGPPSHDDDSPEIDRGRLRSLLLDSLPEGTVRWGRAVTAVRPIGDGTWRLVFEDGSTEEADLVIGADGAWSRVRPSVSDATPAYSGVTFIETGFSDCDTRHPALAALVGKGTMLATADGRALLAQRNGEGHIRVYIAFRAPQDWQAAAGVSFDDVETVRAHVVNLLDGWDGSLLDFVRHSESGFTARPVFVLPVPHTWEHVPGITLLGDAAHLMPPVGLGANLAMLDGSDLAHALVAETSIEEAVLAYEHTVHPRSARAALDCAKALEDILPPQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9H6</accession>
    <name>A0A1E7N9H6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556483.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5452"/>
    <dbReference type="EnsemblBacteria" id="OEV37341">
        <property type="protein sequence ID" value="OEV37341"/>
        <property type="gene ID" value="HS99_0006030"/>
    </dbReference>
    <dbReference type="OMA" id="AQFIVHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="34287" checksum="55A5E92C7E5E50E2" modified="2017-01-18" version="1">MHTVAVLALDQVIPFDLATPLEVFTRVRLPDGRHPYRVRVCGPGARIPAAGFVITAPWGLEGLADADTVIVPGRAEAAPPPGEEVLEALRAAAARGTRIASICAGAFDLALTGLLDGLAATTHWAAAAELARRFPAVEVCPDVLYVDNGQLLTSAGASAGLDLCLHMVRRDFGSAVAADAARLAVTPLEREGGQAQFIVHPQPPVPRGSALEPVLAWLEEHLDEELTLDVMARRSGMSGRTFSRRFREQTGTTPLQWLLRARIRRAQFLLENTDHTIERIADQAGFGSPTAFRERFKRVAGTTPYGYRAAFRSRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA03</accession>
    <name>A0A1E7NA03_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">menG</name>
        <name evidence="2" type="ORF">HS99_0026260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287196.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000346.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7995"/>
    <dbReference type="EnsemblBacteria" id="ARF79051">
        <property type="protein sequence ID" value="ARF79051"/>
        <property type="gene ID" value="B6264_09095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37521">
        <property type="protein sequence ID" value="OEV37521"/>
        <property type="gene ID" value="HS99_0026260"/>
    </dbReference>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24946" checksum="03DA4DF990535AE2" modified="2017-01-18" version="1">MTRASLDKQPHEVAAMFDDVAAKYDLTNDVLSLGQARAWRRAVAEAVAAGPGDLVLDLGAGTGTSSLPFAEAGAQVVPCDFSVGMLTEGKRRHPELPLTAGDATRLPFADDTFDAVTISFALRNVHETDAALREMHRVTKPGGKLVICEFSTPTWTPFRTVYTEYLMRALPPVATAVSSNPDAYVYLAESIRAWPDQPALAARMQESGWSKVAWRNLTGGIVALHRGYKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU1</accession>
    <name>A0A1E7NAU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557062.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000662.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3748"/>
    <dbReference type="EnsemblBacteria" id="ARF78055">
        <property type="protein sequence ID" value="ARF78055"/>
        <property type="gene ID" value="B6264_03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37810">
        <property type="protein sequence ID" value="OEV37810"/>
        <property type="gene ID" value="HS99_0024790"/>
    </dbReference>
    <dbReference type="OMA" id="SYITNDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="47236" checksum="ED09FA7B6368C2D7" modified="2017-01-18" version="1">MPPVRTRSRRRLLALVPAAALALALTACGSGGGSGSGGGSADPAAALDTPATITFWTWAPNLDKTVALFEQKYPKIKVNIVNAGQSATEYTKLQTAVKAGSGGPDVVQVEYFALPELALSKRLVNLKDFGAAGLESKFTPSAWSQVSVGGGVYAVPQDTGPMAMFYNKRILDELGLQPPKTWAEFEAAAVKIKESDPKRFITSIDPGDAGGMDSLMWQAGSRPFQQKDATSVAVNLQDPGAKKVSDLWSSLLSRKLVDAAPGWTNEWWQAMGSGQYAMWLTGAWAPGNIASTLPDSAKDWRAAPMPQWSAGENVSAEQGGSAVAVPSTSKNKAAAAAFAIWLDSDPQAVRSLNENGLFPASSELLKDQAFLDKPLASLGGQQANQVFASSSAAVGQGWQYLPYQVYANSVFKDTVGQGLTGDLGAGLTAWQKRIADYGNQQGFKVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC0</accession>
    <name>A0A1E7NBC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2128"/>
    <dbReference type="EnsemblBacteria" id="ARF82767">
        <property type="protein sequence ID" value="ARF82767"/>
        <property type="gene ID" value="B6264_11425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38006">
        <property type="protein sequence ID" value="OEV38006"/>
        <property type="gene ID" value="HS99_0023755"/>
    </dbReference>
    <dbReference type="OMA" id="TRVDPWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="24405" checksum="629E7AEF0B05FE68" modified="2017-01-18" version="1">MSGATGAAGGPSGGRPGAQGGGTYGGVPEQTPTEHSAASTSLMPPVGGAGQGGGATYGGQTPSGSQGGGQSGFSQPTTYAKGQPTPARGTRTGGNTPPGGTPVPGAARRPSGGPATVGGGLGRTRKARLRVTKVDPWSVMKVSFLLSLAVGIIVIVASAVLWMTLDSLGVFDSLTKTLKDVTGGGADNASSQLNLMDYIGFGKVMMFTTLIAVVDVVLLTALSTLSAFIYNAAAGFTGGVELTLAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBI7</accession>
    <name>A0A1E7NBI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835594.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3050"/>
    <dbReference type="EnsemblBacteria" id="OEV38052">
        <property type="protein sequence ID" value="OEV38052"/>
        <property type="gene ID" value="HS99_0022870"/>
    </dbReference>
    <dbReference type="OMA" id="DIKIQNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198962" evidence="2">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="21949" checksum="A6BA02E503F5E68F" modified="2017-01-18" version="1">MSRSLRRGSIAAIAAIAIASLSSCAASTTPDTLQIKPDNAAATLGTNLRLNNIVLVTGVGTSGDYTGPANVVVNISNTAGTPAELQSITVGSATATFADAAGAPQSSIVVPPGGSVVLGGQGNPSASFSSASVHIGGFATATFAFKDGQKVDAQAGVSPDSGENGRGLYKGFGPTPPPTPTPAAAPTKAATPSAGATATGTPTAPATPSAGATTAGAPVAGATATATAPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC17</accession>
    <name>A0A1E7NC17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA--3-ketoacid-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290081.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000164_gene7228"/>
    <dbReference type="EnsemblBacteria" id="ARF80245">
        <property type="protein sequence ID" value="ARF80245"/>
        <property type="gene ID" value="B6264_16195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38239">
        <property type="protein sequence ID" value="OEV38239"/>
        <property type="gene ID" value="HS99_0022085"/>
    </dbReference>
    <dbReference type="OMA" id="CGTTEYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26646" checksum="2FB15717EA6B2F5C" modified="2017-01-18" version="1">MDKVLDSPAAAVGDIPDGAVLAVGGFGLCGIPSTLIGALVSAGTTGLRVVSNNCGVDDWGLGLLLRAGRISRMTSSYVGENKEFARQYLAGELEVELTPQGTLAERLRAGGAGIPAFFTPAGVGTQVEEGGLPWRYAADGSVALASPPKEVREFGGRRYLLEEAITADFALVRAEVADRHGNCAFHAAARNFNPLCATAGRITLVEADRIVEPGELDPDAVHLPGVYVDRVVAADPEDRRIERRTVRPALQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB1</accession>
    <name>A0A1E7NCB1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate dehydrogenase</fullName>
            <ecNumber evidence="2">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000359.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4135"/>
    <dbReference type="EnsemblBacteria" id="ARF80147">
        <property type="protein sequence ID" value="ARF80147"/>
        <property type="gene ID" value="B6264_15590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38329">
        <property type="protein sequence ID" value="OEV38329"/>
        <property type="gene ID" value="HS99_0022685"/>
    </dbReference>
    <dbReference type="OMA" id="RATRWFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036761">
        <property type="entry name" value="GDH_Mll4104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1648" mass="183352" checksum="7AF04637CB7D9021" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE6</accession>
    <name>A0A1E7NCE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class F sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4158"/>
    <dbReference type="EnsemblBacteria" id="OEV38362">
        <property type="protein sequence ID" value="OEV38362"/>
        <property type="gene ID" value="HS99_0022560"/>
    </dbReference>
    <dbReference type="OMA" id="WYQNGIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="20917" checksum="9A8576F0ED9E3C75" modified="2017-01-18" version="1">MAVGAALVLGAWLLHDGGSAVLPPAPGAGQALSGFAPVSVVPPLGPSTPTRIRIPAVRLDAPVTELGLDPEGHLQAPPETERNLAGWYRGGASPGQRGTAILAGHVDNKSGPAVFYHLGALHRGDRIEIARADGATAVYQLYAIEVHNRKDFPDDRVYRQAADAQLRVITCGGAYSEEHGYEGNVVAYGFLADTTPPGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCI8</accession>
    <name>A0A1E7NCI8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trans-2-enoyl-CoA reductase (NAD(+))</fullName>
            <ecNumber evidence="4">1.3.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0020925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.44" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554442.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene241"/>
    <dbReference type="EnsemblBacteria" id="ARF82231">
        <property type="protein sequence ID" value="ARF82231"/>
        <property type="gene ID" value="B6264_28130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38378">
        <property type="protein sequence ID" value="OEV38378"/>
        <property type="gene ID" value="HS99_0020925"/>
    </dbReference>
    <dbReference type="OMA" id="EGCIEQI"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="42546" checksum="DF8B85C77796536A" modified="2017-01-18" version="1">MSERVLTPRHRGFLFLDSHPAGCARLVADMWQACPGAAELPEGEGPVALIMGSSAGYGLAATVAGLKRAGIRGIAVSYEKAPSGRRTATAGWYRTAATADLARAAGRDLVFLNGDAFSDLMKDQVAELIEQRFGGRLDYLIHSVAAPRRTDPDTGTTYASVLKPIGRANRTRTLVFDEQGVPEVREVETGPAEGDDVEQTVAVMGGADWERWIDHLAGRGLLGEGFATAALSYIGSPLTAAIYRQGTIGAAKLHLEATARTLNERLGRTVGGRAVTSVNGAAVTQSSTAVPGIALYTGLLRGVLGEDMVPPVRQFASLWDQLTGAAPLVPDEEGRIRLDGWELADDVQAAVAERWEAATTGTVAGLADLDWFCAEVRRLYGFSVPGVDYSAAVATDVPWPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM7</accession>
    <name>A0A1E7NCM7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366407.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene326"/>
    <dbReference type="EnsemblBacteria" id="OEV38450">
        <property type="protein sequence ID" value="OEV38450"/>
        <property type="gene ID" value="HS99_0021350"/>
    </dbReference>
    <dbReference type="OMA" id="INVGRLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15713" checksum="D5D378EC184D5C2C" modified="2017-01-18" version="1">MRRALKQRVGRRQLIALETELLAELRAVKRRVPHLAGGLVASVDGLLVAHDTHGAEPSGLAAMTAASLSLAQRLADTTGQGEFRESVVRGEHGYVATYAAGGSCVLTLLAHPDVNVGRLHLEARRCARRIAELLNDALTPKDPRDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR8</accession>
    <name>A0A1E7NCR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288402.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000583.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3080"/>
    <dbReference type="EnsemblBacteria" id="ARF82113">
        <property type="protein sequence ID" value="ARF82113"/>
        <property type="gene ID" value="B6264_27450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38489">
        <property type="protein sequence ID" value="OEV38489"/>
        <property type="gene ID" value="HS99_0021595"/>
    </dbReference>
    <dbReference type="OMA" id="MPGAMTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21340" checksum="804857217C49D67C" modified="2017-01-18" version="1">MNHLSELWDDPVIAVVRAPRIPDAAALCSALAEGGIRFTEFTYTTQDVTGHLTRASASGWRVGVGTVLTAEQAERGIDAGASFLVTPGCRPEVAQAARARGVPVVLGALTPTEVARAVDLGAAAVKIFPARSFGPGYFKDLRGPYPDVPLVASGGVNAGNAAEFLAQGALAVCAGTDVVPPAAVEAGDWAEITRRAREFTRACAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND14</accession>
    <name>A0A1E7ND14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281262.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene657"/>
    <dbReference type="EnsemblBacteria" id="ARF82530">
        <property type="protein sequence ID" value="ARF82530"/>
        <property type="gene ID" value="B6264_00515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38579">
        <property type="protein sequence ID" value="OEV38579"/>
        <property type="gene ID" value="HS99_0020100"/>
    </dbReference>
    <dbReference type="OMA" id="GAIITME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7481" checksum="F8E6E8D28ADA15EA" modified="2017-01-18" version="1">MTGSDVAGEDAEGYAGLRIERARELARRHGWASVRVLEPGQLITLEYREGRLNLAVRDGVVERSWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDJ9</accession>
    <name>A0A1E7NDJ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0018775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737783.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7314"/>
    <dbReference type="EnsemblBacteria" id="OEV38734">
        <property type="protein sequence ID" value="OEV38734"/>
        <property type="gene ID" value="HS99_0018775"/>
    </dbReference>
    <dbReference type="OMA" id="LELCEND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30606" checksum="E161DABBA67F73F1" modified="2017-01-18" version="1" fragment="single">MAMMRLRREDPRIVGPYRLHRRLGAGGMGVVYLGSDRRGQRVALKLIRAELAEDQEFRTRFAREIAAASRIRGGCTARVVGSDIEADRPWLATAYVPGPSLYKQVGDEGPLSWPDAARIGAALADGLVKVHEAGVVHRDLKPSNILLSPRGPRIIDFGIAWSRGASTLTHVGTAVGSPGFLAPEQVRGAAVTPATDVFAFGATLAYALTGDTPFGSGASSEVMLYRVVHEEPDLSAVPPQLAPLIRACLAKEPAERPGAAALHERLSELAARGAAATGGNGRATRRGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDW4</accession>
    <name>A0A1E7NDW4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555473.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6541"/>
    <dbReference type="EnsemblBacteria" id="ARF81310">
        <property type="protein sequence ID" value="ARF81310"/>
        <property type="gene ID" value="B6264_22540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38901">
        <property type="protein sequence ID" value="OEV38901"/>
        <property type="gene ID" value="HS99_0019805"/>
    </dbReference>
    <dbReference type="OMA" id="WARNLAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12959" checksum="D96ACD757ABE4798" modified="2017-01-18" version="1">MRHTLTDLARCLWGDEYGPTPACDAPWQHEESYFTELLTFAGPDEILAMLRTLCPHVVDGYLPVWVRNLAHRLLLLQCPDDPALLREAANSLYSHGPDWDDIAEELTGRADALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ4</accession>
    <name>A0A1E7NDZ4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">HS99_0018970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286360.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7345"/>
    <dbReference type="EnsemblBacteria" id="ARF82990">
        <property type="protein sequence ID" value="ARF82990"/>
        <property type="gene ID" value="B6264_21700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38917">
        <property type="protein sequence ID" value="OEV38917"/>
        <property type="gene ID" value="HS99_0018970"/>
    </dbReference>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="19022" checksum="2A78E9AE97AB2BCD" modified="2017-01-18" version="1">MTADTALAELLNSRIRDVPDYPKPGVLFKDIAPLLADAEAFGALTRALADRAKELGATKVVGLEARGFVLAAPAAVAAGLGFVPIRKQGKLPGEVFRRSYELEYGSATLEVQRDAFAPGERVLVVDDVLATGGTIGASLDLVKEAGAELVGVVVLMELGFLDGRERLAGHLDGAPLETLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE54</accession>
    <name>A0A1E7NE54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83175">
        <property type="protein sequence ID" value="ARF83175"/>
        <property type="gene ID" value="B6264_29965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38952">
        <property type="protein sequence ID" value="OEV38952"/>
        <property type="gene ID" value="HS99_0017710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008813">
        <property type="entry name" value="Plasmid_replication_RepL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05732">
        <property type="entry name" value="RepL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22163" checksum="6CA7B7C96F798C48" modified="2017-01-18" version="1">MAQAERGSTRRQTPERPRQPRLEPAGPQHQRDLAAEIVRGYAGHLPNGIYEARTKFYRRAPHEVLGSDGYALLSRYFARYVLPQALMSGEMTKLQCAVLSNIVGRAERGVCHAIQREIADEVGTSRSSVSPALKHLAARNYIRSIGRGIWQLNPLIAYKGNGDEQQTFLAELRALALENGFPDIIGLEALRNGDKESPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA9</accession>
    <name>A0A1E7NEA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4372"/>
    <dbReference type="EnsemblBacteria" id="ARF83234">
        <property type="protein sequence ID" value="ARF83234"/>
        <property type="gene ID" value="B6264_30305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39004">
        <property type="protein sequence ID" value="OEV39004"/>
        <property type="gene ID" value="HS99_0018035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8884" checksum="C13D6836BC3A1A00" modified="2017-01-18" version="1">MHGVGFIRREGFVFEQVVSDDNVIYDAYTDDDGVVHLSDDYEPGLEIRVAGVVIGGFIYEARTDEWGRVYLVDDEDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC2</accession>
    <name>A0A1E7NEC2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557353.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4352"/>
    <dbReference type="EnsemblBacteria" id="OEV38988">
        <property type="protein sequence ID" value="OEV38988"/>
        <property type="gene ID" value="HS99_0017935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="23494" checksum="067E5683CF932CF7" modified="2017-01-18" version="1">MTDDVRFELRRAFPWWTHTATPALAAHTVPVYDPKTGELLVLCDTRAYLLQTKLLTHSLLAKLNRLTDAPQVTALRLVLASTSVVVTGPAGWADKQLVEDVLLETWHDIVQDRGPLHLLAVRHLEAAGEVGDLAHRWAEAHGQPIEPVLRDARCGCLDTGVDHSHPPLTDEELAARLVTDASLVLAFIDNRALDELIADAAEHARIPVRRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEN9</accession>
    <name>A0A1E7NEN9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285107.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3480"/>
    <dbReference type="EnsemblBacteria" id="OEV39171">
        <property type="protein sequence ID" value="OEV39171"/>
        <property type="gene ID" value="HS99_0000100"/>
    </dbReference>
    <dbReference type="OMA" id="ATLCNDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199058" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="52293" checksum="6ACE17D39985875C" modified="2017-01-18" version="1">MSNTIRRTAAATVAAALAVSVLTALPAAADQGLPGRDHLDWSACQGQADPRQQCATVTVPLDYHDPGGQQITLAVSRIATAKPGLRRGVLLTVPGGPGGSGLGIPASAVKRLPQSVLDRFDLVGFDPRGVGRSTPVSCGLDTPDLAMVKLRPWPAADGSIDANLATERRIAETCARNGGPVLRSISTANEARDIDRIRQALGERKLSAWGTSYGTYAGAVYATMFPGHTDRIVLDSNDDPDPSRVGRGWLAAFGQGAEDRFPDFAKWASAPGNPDRVADTPEQVRPLFLDLADRLDRAPLPWPGANPAELNGNVLRETMLTSLYADAKFPDLARLMLAGLGRRPLPAPVLPPEQAVQNTTAVSVGTLCNDVSWPADPAGYVKDVAADRAARPLTAGMPVNAMPCAFWPFKAAEPPVRVTDRGPANVLLAQNLRDPATPYGGALKLRAAFGDRARMVTVDSGGHDVYLANGNACGDAAVTDFLVTGRRPSEDVFCPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF07</accession>
    <name>A0A1E7NF07_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0000740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3613"/>
    <dbReference type="EnsemblBacteria" id="OEV39277">
        <property type="protein sequence ID" value="OEV39277"/>
        <property type="gene ID" value="HS99_0000740"/>
    </dbReference>
    <dbReference type="OMA" id="QIGNVVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199070" description="GRAM_POS_ANCHORING domain-containing protein" evidence="6">
        <location>
            <begin position="45"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="887"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="851"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="925" mass="96225" checksum="1ED244899A08F617" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF13</accession>
    <name>A0A1E7NF13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550250.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3637"/>
    <dbReference type="EnsemblBacteria" id="OEV39296">
        <property type="protein sequence ID" value="OEV39296"/>
        <property type="gene ID" value="HS99_0000855"/>
    </dbReference>
    <dbReference type="OMA" id="PAEVNYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="32395" checksum="2CE8A45B319FC8A9" modified="2017-01-18" version="1">MVRSEWAAGLGRLVGAAAELGEAGRQAVLRGGRSAAGGRWALAALGSVAPPQVPVSEPWKLSLGMLIGRHPRTPGVVHKLLGLLDGYGAVHLGPSKVGFDGEEVEWDKVVEVRTRNAFEVLTTSALEQDVDRIREFLPPLPGRKWAVTRAGEALATVVLAALERGSVDQRLDELTVPAQIVHRGLLGRPRTLDAGCFAAATLVIVGQARESLIATARQRGIPVRPAAAAAEDDRAEHVAVLRERTDAVARLLSRIERSDPDAAETADEAEEAETADEAGTSAAPPQLSLAKAPLDRGPVDHEVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF94</accession>
    <name>A0A1E7NF94_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555990.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1513"/>
    <dbReference type="EnsemblBacteria" id="OEV39344">
        <property type="protein sequence ID" value="OEV39344"/>
        <property type="gene ID" value="HS99_0001125"/>
    </dbReference>
    <dbReference type="OMA" id="RTWRRSD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="16081" checksum="0BD4D7470E614724" modified="2017-01-18" version="1">MTVRTRALEGLAAGAVGTTALNAVTYLDMAVRGRAASEAPQEAVETLADRAGVSVPGDHDERDNRIAGLGPLLGLGTGLAVGLGIGVLTAAVKAPAGRAGACIVALGAAAAALAASDAPMAALGISDPREWEPADWAADIVPHLAYGAATAAVLLTLRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG6</accession>
    <name>A0A1E7NFG6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557682.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7537"/>
    <dbReference type="EnsemblBacteria" id="OEV39427">
        <property type="protein sequence ID" value="OEV39427"/>
        <property type="gene ID" value="HS99_0001630"/>
    </dbReference>
    <dbReference type="OMA" id="LDEGIAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="31711" checksum="541A087C640426A7" modified="2017-01-18" version="1">MTTPTAPLGARPVCRIGYGALQLERLHDRRDEAVVLLRRAVELGVDHVDTAEFYGFGFANDVIREALRPEDDVLVVTKVGADPNPGGHLPLRLAQRPEQLRASVEDNLRSLGVDRLAVVNLRRLDTGPGLRPEGDQIIDLDDQLAVMTALRDEGKIGEIGLSSVTLDGLRRALPAGVVCVQNAYSLVSRDDEDLLRLCAAEGIAWVPFFPLGGAFPGLPKATDEPAVHAVAESLDVTPSQVGLAWLLHHSPNVLLIPGTADLAHLEANVAVGEITLDAATLATLDGIRSRSNDVPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH1</accession>
    <name>A0A1E7NFH1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043482100.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39456">
        <property type="protein sequence ID" value="OEV39456"/>
        <property type="gene ID" value="HS99_0001790"/>
    </dbReference>
    <dbReference type="OMA" id="WAVEWER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039708">
        <property type="entry name" value="MT1774/Rv1733c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42305">
        <property type="entry name" value="PTHR42305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20303" checksum="E450DAACCD65271D" modified="2017-01-18" version="1">MSTHPSRRNPVRRTSDRIQWWLARVLLAVMVIGLPAAAVSAGLLTYRAQMHTGHVESSARHTVTAHLTAAAPVPSNNDYSRVPATAAWTAADGTTHTATVRMWPGERAGTPVPLWVNHQDTVTSAPLTRGQAAAAAWTTAAMTAGTLSLLCLAAWKGSVCVLDHHRYAQWDAEWSQVEPRWSKRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK2</accession>
    <name>A0A1E7NFK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3121"/>
    <dbReference type="EnsemblBacteria" id="OEV39454">
        <property type="protein sequence ID" value="OEV39454"/>
        <property type="gene ID" value="HS99_0001780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12221" checksum="7D74B6A55E6C0408" modified="2017-01-18" version="1">MVVLAAVDGSPERLAAARWTADEAVWRRCHRTRASDRVDAPPSADSRKDPGRRGRSRSTASAAALRRFCWTRACSWSDPVATGLWGRLALGSTSTEIVHHAHLPVVVPGEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM5</accession>
    <name>A0A1E7NFM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385803.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5052"/>
    <dbReference type="EnsemblBacteria" id="OEV39509">
        <property type="protein sequence ID" value="OEV39509"/>
        <property type="gene ID" value="HS99_0002115"/>
    </dbReference>
    <dbReference type="OMA" id="GYATNPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="788" mass="80537" checksum="D35FF7772A2B4B4A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFR6</accession>
    <name>A0A1E7NFR6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6745"/>
    <dbReference type="EnsemblBacteria" id="OEV39550">
        <property type="protein sequence ID" value="OEV39550"/>
        <property type="gene ID" value="HS99_0002375"/>
    </dbReference>
    <dbReference type="OMA" id="THARCLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="157"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30195" checksum="1E64461BFA28EE61" modified="2017-01-18" version="1">MNGFESLRPVIVGVDRSEASHWAVRWAADEAAGHHLPLRLLHAQEWPVDRATDVADHPWAIGLRAAGEAVLETARLLATERHPTLEITSELAEGRPVRVLRDAADEATQLVLGVRRVSEAHSALRIGSKGASLAGHLSCPLALVPEPADGLSGPGPVVVGVDGSPASRAAVGFAFEEASIGGTDVLAVEVRRPTEAGRPELVEESLTDLSESLAGWQEKYPEVRVRREVLTGSPAPMLATVATHARCLVIGSRGLGGFRGLLFGSTGRALVHRCTVPLVIVPNGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG19</accession>
    <name>A0A1E7NG19_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555574.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6699"/>
    <dbReference type="EnsemblBacteria" id="OEV39588">
        <property type="protein sequence ID" value="OEV39588"/>
        <property type="gene ID" value="HS99_0002615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7428" checksum="A07453F3E2E2E2EC" modified="2017-01-18" version="1">MPALALTPPEAARWAARAGLRLPAERHAAVTVVADHIHHVVAVLRELDFEDVPPAAAYHPVQEAHRAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG28</accession>
    <name>A0A1E7NG28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550347.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000789.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2775"/>
    <dbReference type="EnsemblBacteria" id="OEV39637">
        <property type="protein sequence ID" value="OEV39637"/>
        <property type="gene ID" value="HS99_0002905"/>
    </dbReference>
    <dbReference type="OMA" id="VQQPFEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199193" evidence="1">
        <location>
            <begin position="35"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="90"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="382" mass="38779" checksum="035D5D57933CFC2A" modified="2017-01-18" version="1">MRAPLPRPTRAARIASAAIVTLALTLAVGCSKQGAGDPGPSTGGSPAAAPAIQGDITFNDDNLTRLDAALKSALQGKDLSQLDLAMVVNVAVDYWNAGKAGFDKGLADLGVKGTFQAPANGRLDQQLSILQTLRGQSISAFSLSAIDPTAVKSPIQSASSAGIPVLAIDSPLPAEDGAALYLGTPNYQAGKRAGEAMKAALGGRGKVVVLVGSLTASNAVERIQGFEDALKGTDIKVSNKLADNMDAAKALTNAQTAIQTDPGVTGLYGVYSYDGPSAAQAVQAAGRAGKVKVISDDSDAQTLTFIQQGVIQATVVQSPYQQGYTGAYLLAALKVLGRDATMAVVKPLLESDGSTLSSGVGVVTPDNLGAFRAKQTQLGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG76</accession>
    <name>A0A1E7NG76_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Aspartate ammonia-lyase</fullName>
            <shortName evidence="5">Aspartase</shortName>
            <ecNumber evidence="3 5">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0002835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 5"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2761"/>
    <dbReference type="EnsemblBacteria" id="OEV39625">
        <property type="protein sequence ID" value="OEV39625"/>
        <property type="gene ID" value="HS99_0002835"/>
    </dbReference>
    <dbReference type="OMA" id="EAMNQTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="7">
        <location>
            <begin position="410"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="469" mass="49320" checksum="BCEF77BAEF7EF468" modified="2017-01-18" version="1">MTTATRSEHDLLGDRDVPADAYWGVHTLRATENFPITGTPISTYPHLIDALAAVKEAAALANEELGLLEPRKAAAIVAACREIRGGKLHDQFVVDVIQGGAGTSTNMNANEVVANRGLELLGHAKGEYPHLHPNEDVNLGQSTNDVYPTAVRIATVYAVRGLLDAMAVLQDAFARKAVEFRDVLKMGRTQLQDAVPMTLGQEFSAFAVMLDEDRSRLAEAVELIYEINLGATAIGTGLNAPAGYAEAARRHLADICGLPLVTAANLVEATQDCGAFVQMSGVLKRIAVKLSKTCNDLRLLSSGPRAGLGEINLPPVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDVAVTMAAEAGQLQLNAFEPIILHSLSESITHLRAACLTLAERCVVGITANTEVLRATVENSIGLVTALNPHIGYTAATEIAKEALASGRGVAELVLEKGLLPAERLAALLRPEVIAGSGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGE8</accession>
    <name>A0A1E7NGE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0003325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2858"/>
    <dbReference type="EnsemblBacteria" id="OEV39705">
        <property type="protein sequence ID" value="OEV39705"/>
        <property type="gene ID" value="HS99_0003325"/>
    </dbReference>
    <dbReference type="OMA" id="PKAARYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199120" evidence="7">
        <location>
            <begin position="35"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="8">
        <location>
            <begin position="1334"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV39705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1514" mass="155544" checksum="F4F89BA6AFAA708D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK3</accession>
    <name>A0A1E7NGK3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3606"/>
    <dbReference type="EnsemblBacteria" id="OEV39802">
        <property type="protein sequence ID" value="OEV39802"/>
        <property type="gene ID" value="HS99_0000705"/>
    </dbReference>
    <dbReference type="OMA" id="FNNAGCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="35"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="44582" checksum="0AB4E5B27AF509DA" modified="2017-01-18" version="1">MNAGQERVLDLSREPLLDLAALRADTPGCEAVIHFNNAGAGLMARPVLETVLDHLRLEAGIGGYEAAAARAAEVADFYAALAELLGTRPGNLAFAASATHAYAKALSAIDFRPGDVVLTTRNDFVSNQIAFLSLRRRHGVRIVHAPDHPDGSGVDVEAMAALMRAHRPRLVAVTHVPTNSGLVQPVAEIGRHCRELDLLYLVDACQSVGQYPIDVETIGCDLLTATCRKFLRGPRGSGFLYVSDRVLAAGYEPLHIDMHGARWVAPGYYRPVGTAARFEEWEFPYATVLGCAAAVRYALRVGLEPVARRTPALAGRLRERLAAVPRVRTLDGGPAPAALVTFTIEGWQAAPFKAAMDARGINSALSYREFAQFDFADKEVEWCLRLSPHYYNTEDEVDAAAGTVAELARSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM9</accession>
    <name>A0A1E7NGM9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1500"/>
    <dbReference type="EnsemblBacteria" id="OEV39808">
        <property type="protein sequence ID" value="OEV39808"/>
        <property type="gene ID" value="HS99_0001060"/>
    </dbReference>
    <dbReference type="OMA" id="QVLMEAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="31"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13629" checksum="5975A46F7C7168A7" modified="2017-01-18" version="1">MPSDNGRGEATLVTALPRPGLEVRSRATETGAVVCALAGDLDIETLASAAETLTGLVAQRPSALVVDLREVAFCDSSGLNLLLRTRIAAEKEGLHLRLAAVAPTVLRVLELTGARTVFTIHETVEEALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH28</accession>
    <name>A0A1E7NH28_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ORF">HS99_0003685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386207.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2934"/>
    <dbReference type="EnsemblBacteria" id="OEV39763">
        <property type="protein sequence ID" value="OEV39763"/>
        <property type="gene ID" value="HS99_0003685"/>
    </dbReference>
    <dbReference type="OMA" id="IMMGPGS"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="35807" checksum="A56B616584EB5B03" modified="2017-01-18" version="1">MTDTPTSTPPVTAHHLLAGNENPYPPLPGVLERATAALHTLNRYPDPAATRLVAALADHLNVPSAHVVVGPGSVGVLFQLVRAAAGPGDEVLFAWRSFEAYPEAAELAGATAAAVPLADGEVHDLTAMAAALTPRTKVVLVCNPNNPTGTAVPPAELVKFLDAIPDTTLVVLDEAYREFAPEDTPDGIDLYRTRPNLVVLRTFSKAYGLAGLRVGYAVAHDTVAAAARAVALPFGVSRIAQDAAVESLAAGSELHDRVRNLVAERNRVQAALRTQGWPLVESHANFVWLRLGEHTSAFAASCTEAGITAKVFPGEGVRLSIGEPDANDAALAVAAAWRARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SMD0</accession>
    <name>A0A176SMD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0006330</name>
        <name evidence="5" type="ORF">HS99_0017735</name>
        <name evidence="4" type="ORF">HS99_0019585</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558521.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000189_gene7506"/>
    <dbReference type="EnsemblBacteria" id="ARF81271">
        <property type="protein sequence ID" value="ARF81271"/>
        <property type="gene ID" value="B6264_22320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82505">
        <property type="protein sequence ID" value="ARF82505"/>
        <property type="gene ID" value="B6264_29805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83179">
        <property type="protein sequence ID" value="ARF83179"/>
        <property type="gene ID" value="B6264_29995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37391">
        <property type="protein sequence ID" value="OEV37391"/>
        <property type="gene ID" value="HS99_0006330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38866">
        <property type="protein sequence ID" value="OEV38866"/>
        <property type="gene ID" value="HS99_0019585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38956">
        <property type="protein sequence ID" value="OEV38956"/>
        <property type="gene ID" value="HS99_0017735"/>
    </dbReference>
    <dbReference type="OMA" id="MAKGARY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="12151" checksum="9885E3CFE941CEE3" modified="2016-09-07" version="1">MAAPMKYPPELRRRAVEMYRTADPKPVIRKMARDLGVHHEALRNWIRQDEADRGERDDRLTTAEKEELAALRKENAELRRSCEILKAASAFFAQELDPTRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV51</accession>
    <name>A0A1E7MV51_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF4040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0016515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000131.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6890"/>
    <dbReference type="EnsemblBacteria" id="OEV32310">
        <property type="protein sequence ID" value="OEV32310"/>
        <property type="gene ID" value="HS99_0016515"/>
    </dbReference>
    <dbReference type="OMA" id="VFAMAGN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="9531" checksum="563987D546B3A612" modified="2017-01-18" version="1">MTNALTVIALLLTAVTATTAALTREPVRQAVVLAFLGLCLALLFTVLQAPDVALSQLGVGSAITPLLILLTVRRVRRQEQADEHPDRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVB7</accession>
    <name>A0A1E7MVB7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000462.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6962"/>
    <dbReference type="EnsemblBacteria" id="OEV32368">
        <property type="protein sequence ID" value="OEV32368"/>
        <property type="gene ID" value="HS99_0016860"/>
    </dbReference>
    <dbReference type="OMA" id="YNHLLAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32976" checksum="DCC5D9D68FE48A0C" modified="2017-01-18" version="1">MIEAHQLTKRYGEKTAVDGLDFTVRPGAVTGFLGPNGAGKSTTMRMIVGLDAPTSGSVRVNGRRYAEHAAPLQEVGALLEAKSIHPGRSAFNHLMAQAHTHGIPRRRVEEVIELTGLQSVARKRAGAFSLGMGQRLGIAAALLGDPATVMLDEPVNGLDPEGVLWIRNLLTSLAAEGRTVFVSSHLMSEVSLVADHLIIVGRGKLLADTTVQELVQQAGGDVVKVASADPARLRSLLAGPGVEITGRTGSEELLVAGRTAREIGLTAAEHGIAVFELTPRTVSLEEAFMDLTRDAVEYHGTTTTTETTRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM1</accession>
    <name>A0A1E7MVM1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tautomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557468.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000691.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1231"/>
    <dbReference type="EnsemblBacteria" id="OEV32482">
        <property type="protein sequence ID" value="OEV32482"/>
        <property type="gene ID" value="HS99_0017540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037479">
        <property type="entry name" value="Tauto_MSAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38460">
        <property type="entry name" value="PTHR38460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14552">
        <property type="entry name" value="Tautomerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="14569" checksum="B8207C04A457531F" modified="2017-01-18" version="1">MPFVRIDALGAGSERLGALGRAVHEALVEAIGIPPNDHFQVLVGHDGTNSLLRYGDYLGVRRDEGIVYVAITLRAGRTDAQKRALYARIAELAQAYAGTEPRNVFVVLTENTSADWSLGHGLAQYALPDGEGVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP0</accession>
    <name>A0A1E7MVP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550532.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2956"/>
    <dbReference type="EnsemblBacteria" id="OEV32499">
        <property type="protein sequence ID" value="OEV32499"/>
        <property type="gene ID" value="HS99_0016170"/>
    </dbReference>
    <dbReference type="OMA" id="GLWRATF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="251" mass="26927" checksum="519B907392BD291B" modified="2017-01-18" version="1">MTRQGATRRWSGRLQARSFGLAAASYQHGRPGYPQALIGSAVPREARRVLDLGAGTGKLTALLVDAGLDVVAVEPDGGMRDRLAAAVPKAAVRAGSAERIPLPDASVDAVVVAQAWHWFDRTTAVPEIARVLAPGGTLSLVWNVRDETEPWAAALGALMHRSARQQIDTAPVLPAPFGPPERLEIRWEHSTTPAGIIDLVASRSYVIALPEAERARLLADVEHLLTTHPGLAGREEIAMPYVTRCTRVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVZ6</accession>
    <name>A0A1E7MVZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287913.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3825"/>
    <dbReference type="EnsemblBacteria" id="ARF78354">
        <property type="protein sequence ID" value="ARF78354"/>
        <property type="gene ID" value="B6264_04955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32606">
        <property type="protein sequence ID" value="OEV32606"/>
        <property type="gene ID" value="HS99_0015125"/>
    </dbReference>
    <dbReference type="OMA" id="CHNLETA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="26367" checksum="16343BB2DCB3C34F" modified="2017-01-18" version="1">MAHGQWAVELRSVEKKYGRGAGEVAALRDLSLSFDRGSFTAVMGPSGAGKSTFLHCAAGLDRPTSGSVWLAGTDLATLDEAQLTMLRRERVGFIFQAYNLLGSLTVAENITLPLLLAGVAAEPGWLDQVARRVGLSDRLQHRPAQLSGGQQQRVAIARALITKPEVIFADEPTGALDSRTGRQVLSLLREIVDRDGNTVVMVTHDPVAASFAQRVVFLADGAFAEEMAAPTADRVAARMTRLEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW65</accession>
    <name>A0A1E7MW65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">HS99_0015475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3158"/>
    <dbReference type="EnsemblBacteria" id="ARF78293">
        <property type="protein sequence ID" value="ARF78293"/>
        <property type="gene ID" value="B6264_04610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32670">
        <property type="protein sequence ID" value="OEV32670"/>
        <property type="gene ID" value="HS99_0015475"/>
    </dbReference>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="316"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV32670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="469" mass="48256" checksum="7E0BA5008C0E381D" modified="2017-01-18" version="1">MNDAAHDLHAPHFIGIGGAGMSGLAKILAVRGADVSGSDSKESETVLALRALGATVHVGHAAEHVPDGASSIVVSSAIRADNPELVAARERGIPVVHRSDALAALMGGRRALAVAGTHGKTTTTSMLAVALGELGLDPSYAIGGDLDAPGSNAQHGTGEIFVAEADESDRSFHKYAPEVAIVLNVELDHHANYASIDEIYESFETFVGRITPGGTLVVSADHDGARELTSRVAAREGLNVVTVGAAEDADLRVLSVVARGMTSEVTVLLDGAELTFTVSVPGRHYAHNAVAALAAGVALGVPAADLAKALGAYTGVRRRLQLKGEAAGVQVIDSYAHHPTEMTADLEAIREGLEGEGRVLVVFQPHLFSRTQQLAEEMGQSLALADASVVLDIYPAREDPIPGVTSELIIDAARRAGADVTAEHDFAAAPALLAGLARPGDLLLTMGAGDVTNLGPEILGHLANVASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW81</accession>
    <name>A0A1E7MW81_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0015540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3172"/>
    <dbReference type="EnsemblBacteria" id="OEV32681">
        <property type="protein sequence ID" value="OEV32681"/>
        <property type="gene ID" value="HS99_0015540"/>
    </dbReference>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="38158" checksum="BF5CBB52C5E34135" modified="2017-01-18" version="1">MSVAGYVPGRQPQSRTGERAGSPSPSRPRSSPARANPAPRITALGGGQGLSASLSALRRLTSDLTAVVTVADDGGSSGRLREELGVLPPGDLRKALAALCGDDDWGRTWSEVIQQRFTGNGELGGHAVGNLLIVALWEKLGDPVAALDWVGRLLNVQGRVLPMSAVPLDIEATVRGHDPARPAEVSAVRGQASVAATPGTVQSIRLLPDEPPAVPEAVTAVREADWVVLGPGSWFTSVLPHLLVPELAKALTETRARRLLTLNLAPQPGETEGFTPQRHLEVIADHAPDLAVDAILVDERAVTGGAFGQADLEGLEKAAERMGAALVLGTVARADGTPRHDPELLAAAYDRIFRTHGRIGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV8</accession>
    <name>A0A1E7MWV8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 2 glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738005.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000078.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene85"/>
    <dbReference type="EnsemblBacteria" id="OEV32904">
        <property type="protein sequence ID" value="OEV32904"/>
        <property type="gene ID" value="HS99_0039585"/>
    </dbReference>
    <dbReference type="OMA" id="MRDDVDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1118" mass="115471" checksum="CE872B9BF809AA80" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX05</accession>
    <name>A0A1E7MX05_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5737"/>
    <dbReference type="EnsemblBacteria" id="OEV32972">
        <property type="protein sequence ID" value="OEV32972"/>
        <property type="gene ID" value="HS99_0013915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9203" checksum="5BBBF31941B184B4" modified="2017-01-18" version="1">MQERLAQLWTARLEISPIGLDDDFFELGGDSLTAAELQGDIDKEFGVEVSATTLFLSPTITELTQVIEEAVAAAPSGTTGAHPGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA5</accession>
    <name>A0A1E7MXA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent succinic semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552418.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5623"/>
    <dbReference type="EnsemblBacteria" id="ARF81483">
        <property type="protein sequence ID" value="ARF81483"/>
        <property type="gene ID" value="B6264_23510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33067">
        <property type="protein sequence ID" value="OEV33067"/>
        <property type="gene ID" value="HS99_0014480"/>
    </dbReference>
    <dbReference type="OMA" id="KAMRWYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="49999" checksum="7FB0DAE76D7B45D0" modified="2017-01-18" version="1">MPIASVNPATGEILQTFEPLDAAGIEQRLARAEAAFHGHRSTPFTARAELMHRAADLLDRDQETVARTMTEEMGKPLTAARAEAAKCAKAMRWYADNAEALLADEHPAQADVTDSGATRAYVRYRPMGPVLAVMPWNFPFWQVIRFAAPALMAGNVGLLKHASNVPRTALAIEELFQRAGFPEGCFQTLLIGSDAVEDVIRDRRVAAVTLTGSEPAGRAVAAAAADEVKKAVLELGGSDPYVVLPSADLEAAVATAVRARVQNNGQSCIAAKRFIVHTDVYDRFTSAFTEAMRALRIGDPMDEGTDVGPLASRQGRDDLEELVEDARTHGARVECGGDRPMGWDTGWFYEPTVLTGVTPAMRIHQEETFGPVATVYRVADLDEALALANDTPFGLSSNVWTTDRDEQERFVRDIQAGGVFFNGMTASHPALPFGGVKRSGFGRELSGHGIREFCNVTTVWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXD5</accession>
    <name>A0A1E7MXD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290343.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3428"/>
    <dbReference type="EnsemblBacteria" id="OEV33097">
        <property type="protein sequence ID" value="OEV33097"/>
        <property type="gene ID" value="HS99_0014670"/>
    </dbReference>
    <dbReference type="OMA" id="VRHLGPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13776" checksum="A593913CD859AFA1" modified="2017-01-18" version="1">MRVFRRRSRAGDQSVPARRSAGARESGAVAPVGAVNGYAVLETVAALPVSTWRYFWEPEDVRHLGPMAQDWHAAFGFNRDDTTISVVDGLGVALVCVQALHRRVEELTAEVDRLREAASMNTPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXD6</accession>
    <name>A0A1E7MXD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5616"/>
    <dbReference type="EnsemblBacteria" id="OEV33074">
        <property type="protein sequence ID" value="OEV33074"/>
        <property type="gene ID" value="HS99_0014515"/>
    </dbReference>
    <dbReference type="OMA" id="NLGQDAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="22779" checksum="2FB11EC798CBFC04" modified="2017-01-18" version="1">MDIGPVTRTLRAAVFAALVVLLAGLGQVLVTGRSLPVGTMGLASVAVFALAFALAGRERGYPVIAAAFVPLELAVSTLFDFAQRSCPTLPPGAGHGFRPLLCGGGSLGGFLLGHGVSEQTGVLLLLLLHTVIALAGAFWLRRAEAALSGLTRALRVLGEFLHRHLPAAARWLRLLLAPVPARPVVRVPFPSASRSMVPAEDAVVRPAVRRGPPVFALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY5</accession>
    <name>A0A1E7MXY5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0038780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3279"/>
    <dbReference type="EnsemblBacteria" id="OEV33305">
        <property type="protein sequence ID" value="OEV33305"/>
        <property type="gene ID" value="HS99_0038780"/>
    </dbReference>
    <dbReference type="OMA" id="LFMLPMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="829"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="942"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="350"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="722"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1083"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1293" mass="138955" checksum="D504B1DF096D146C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY6</accession>
    <name>A0A1E7MXY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556868.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33296">
        <property type="protein sequence ID" value="OEV33296"/>
        <property type="gene ID" value="HS99_0038765"/>
    </dbReference>
    <dbReference type="OMA" id="LHGWEST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="44520" checksum="699915F3AB913C2B" modified="2017-01-18" version="1">MTSLHPSSTDPALPGPPADGADSSAGADAPPVAAGPTVTAVLSGPADSDAPFVPADRVHPAAPVGPAAPGARVCSIAAVAEGGPTGAAGAPTRHDRVPQPRTPEDVETQLRRAPADGGAAASGGTPASGGTTADRLRAAFADRLRAARAEGRSLAELAAACRRSVEEVRALLGEAGEEEGGVSGALLDGAGPGFVRFQQAAASESNRTVPVPSSAREPSREPSREPTREPTRESVRQEVRGLSSRRPSPSRRLRRMHPPADRSGQGATARETAAADPTGGQPRGAGRAGEPTGARRTAADHTPPTAGADAWAVVDGGAEQPRAVPPLGILIGGSPVQPEAVGRPEERTPVRVAAEPIRVGRGTSLVVLPSWRPAIAVSVPTEQLVLETGLTAEQLTGARLTVRMNPWALHDRELDLHGWEPGPTGPHGRPRRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA4</accession>
    <name>A0A1E7MYA4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557599.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7095"/>
    <dbReference type="EnsemblBacteria" id="OEV33213">
        <property type="protein sequence ID" value="OEV33213"/>
        <property type="gene ID" value="HS99_0039190"/>
    </dbReference>
    <dbReference type="OMA" id="SWQCANA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198543" evidence="1">
        <location>
            <begin position="36"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35349" checksum="A3191738041E7491" modified="2017-01-18" version="1">MTTHLKNGVRVLPALAAALCGIVGGTTLGTSPAAAADQRHPIYAIAHRVDTLDGVDAALKHGANGIEIDVCSWWNPNEWRAYHDCSSAGDNRRGPGFDSMIDRILSNANAGRRLSLVWLDIKDPNYCGEEPNRTCSVAGLHDKAQRLTAAGIQVIYGFFEYHGGNTPDVGGRGWKSLEGKLGRLEGMTTTGTRDQVQNAFTRSGSGIPAGHRAMDYGDSDITKGFGNCTEATWNTCTELKKGAADRASGQLAATLSWTTTYNDPWYVDKLLGDARVDGIIAGYGAFTGVREYDDSWQCANAVTLVRDWVNRHSSTHRMANSGDRLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYL9</accession>
    <name>A0A1E7MYL9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549928.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5192"/>
    <dbReference type="EnsemblBacteria" id="ARF80617">
        <property type="protein sequence ID" value="ARF80617"/>
        <property type="gene ID" value="B6264_18440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33514">
        <property type="protein sequence ID" value="OEV33514"/>
        <property type="gene ID" value="HS99_0013220"/>
    </dbReference>
    <dbReference type="OMA" id="PWGIAES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1131" mass="122446" checksum="D6031CB427B6DC78" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYM8</accession>
    <name>A0A1E7MYM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxylacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282608.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5217"/>
    <dbReference type="EnsemblBacteria" id="ARF80639">
        <property type="protein sequence ID" value="ARF80639"/>
        <property type="gene ID" value="B6264_18565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33536">
        <property type="protein sequence ID" value="OEV33536"/>
        <property type="gene ID" value="HS99_0013345"/>
    </dbReference>
    <dbReference type="OMA" id="RRHWFNM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15259" checksum="49FADFC199BEF286" modified="2017-01-18" version="1">MTGSLYEEVQHFYGRQMRHLDEGEVTEWAATFTEDGVFAANARPHPQEGRAAIEQGAREAAQRLADAGIRHRHWLGMLEVAAQPDGLVLAKTYALIVATPKGGPAAVHLSCSCEDQLVRVDGELKVRHRRVHRDDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU1</accession>
    <name>A0A1E7MYU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287593.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3986"/>
    <dbReference type="EnsemblBacteria" id="ARF82892">
        <property type="protein sequence ID" value="ARF82892"/>
        <property type="gene ID" value="B6264_17745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33589">
        <property type="protein sequence ID" value="OEV33589"/>
        <property type="gene ID" value="HS99_0012520"/>
    </dbReference>
    <dbReference type="OMA" id="NLMVVLC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="32829" checksum="2D2BC2D8E25738A9" modified="2017-01-18" version="1">MAVEDGPDIDLPAPKITERVITGAAGLPVLGAALLGLLAGFGALIAGGVQISGGSKGVGIPLVVVGPLVVLGSLLLLCGLTVISPGQARVVQLLGRYRGTIRAAGLTWVNPFTSRRRISTRIRNHETETTKVNDADGNPIEMAAVVVWQVEDTAMAVFEVDDYVDFVAIQTETAVRHIATSYPYDAHHEGQLSLRDGADEIARKLSAEIAARVASAGVRVIESRITRLAYAPEVAQVMLQRQQAGAVVAARRLIVEGAVGMVEEALDRLAERDVVELDEERKAAMVSNLLVVLCGDRGTQPVVNTGSLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC1</accession>
    <name>A0A1E7MZC1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0037630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283719.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000336.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4521"/>
    <dbReference type="EnsemblBacteria" id="ARF80379">
        <property type="protein sequence ID" value="ARF80379"/>
        <property type="gene ID" value="B6264_17005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33800">
        <property type="protein sequence ID" value="OEV33800"/>
        <property type="gene ID" value="HS99_0037630"/>
    </dbReference>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="36748" checksum="5F40A214A03DDBDA" modified="2017-01-18" version="1">MAFNLRNRHFLKETDFTPQEFRFLVDLAAGLKAAKYAGTEQPRLRGKNIALIFEKTSTRTRCAFEVAAHDQGATTTYLEPSGSQMGHKESVKDTARVLGRMFDGIEYRGHGQEIVEELAQHAGVPVWNGLTDEWHPTQMLADVLTVTEHTTKPLTDVALAYLGDARSNMGNSLLVTGALLGMDVRIVAPRALWPAEEVRKAAQALAEQTGAMITLTEDVAEGVAGVDFLYTDVWVSMGEPKEVWAERIELLKPYQVSMDTVRATGNPNVKFLHCLPAFHDLGTVIGRQMYEATGMTELECTDELFESAHSIVFDQAENRLHTIKAVLVATLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD5</accession>
    <name>A0A1E7MZD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366790.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80395">
        <property type="protein sequence ID" value="ARF80395"/>
        <property type="gene ID" value="B6264_17085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33815">
        <property type="protein sequence ID" value="OEV33815"/>
        <property type="gene ID" value="HS99_0037710"/>
    </dbReference>
    <dbReference type="OMA" id="VCPYGST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20352" checksum="F7A57C2CD4881010" modified="2017-01-18" version="1">MPRPAATPRPAPTSRPAPTPPPPFPPLLPDGSGLVAEIEAYLASLPAPARTPGPYVCPYGSTPSPWHAGHPAPRATLLDRALRRPARPVPVTAADHLRLASRYIGAHGWLQGAMWDAAGRVCLLGAQAAVLAYGYGTPATVRTARVQLMEVLHATGRPARSPDEYNDRPTTREGDVHQLLDRAAARAARLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI6</accession>
    <name>A0A1E7MZI6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386257.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000283.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000100_gene7487"/>
    <dbReference type="EnsemblBacteria" id="OEV33633">
        <property type="protein sequence ID" value="OEV33633"/>
        <property type="gene ID" value="HS99_0038705"/>
    </dbReference>
    <dbReference type="OMA" id="IKLELEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13524" checksum="AC6F6FA478DAF959" modified="2017-01-18" version="1">MALPAGCDSCEGVDVKYLVELPVEGEAGLGQLVRVEVEPAGEGLIQVSRPGQVAARAARSLGEMLAGIRPVAESFVEGLGGMAQAPEEISLEFGLSMSAEADLVISTTTAQANFKVSLTWRPPSAEAGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN1</accession>
    <name>A0A1E7MZN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283054.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1827"/>
    <dbReference type="EnsemblBacteria" id="ARF77737">
        <property type="protein sequence ID" value="ARF77737"/>
        <property type="gene ID" value="B6264_01285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33894">
        <property type="protein sequence ID" value="OEV33894"/>
        <property type="gene ID" value="HS99_0010445"/>
    </dbReference>
    <dbReference type="OMA" id="LPAGYHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018960">
        <property type="entry name" value="DUF1990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014457">
        <property type="entry name" value="UCP010260"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09348">
        <property type="entry name" value="DUF1990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010260">
        <property type="entry name" value="UCP010260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20251" checksum="0EBDFF9E5CCD0E51" modified="2017-01-18" version="1">MVGDLQQRLRAARATEPTYPEVGATRRGRLPDGYAHLRRRVHLGHGPEVLERAGRYVLGWGSQLGTGFAVYPGGPAREGATVLLRLSLPGSRWPRLVIPCRVVWTVAEPDRIGFAYGTLPGHPECGEESFLVSMDAEGEVWFEVAAFSRLSAWYARLGRPVALLCQHLAIERYLAALAGHVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0B6</accession>
    <name>A0A1E7N0B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557287.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3719"/>
    <dbReference type="EnsemblBacteria" id="ARF77993">
        <property type="protein sequence ID" value="ARF77993"/>
        <property type="gene ID" value="B6264_02765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34129">
        <property type="protein sequence ID" value="OEV34129"/>
        <property type="gene ID" value="HS99_0011910"/>
    </dbReference>
    <dbReference type="OMA" id="SIFCKAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008799">
        <property type="entry name" value="Pseudomon_AvrD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05655">
        <property type="entry name" value="AvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37527" checksum="0C72DB6E8859313E" modified="2017-01-18" version="1">MTTQVANTPPASVDDYLGPGDRRFFGRGFRRVHYDLSRIRVVRTPDGVAGASAVVGVRYPADWSRKAVGDLRPHFSTVDGLVLAAQLAELCLSDRRGDDLSEAWLREVRITAGSRPQEDLDQLEAAATRRRVEALDGAPGWSVSVIDCRIGTMRVRCELVHRSGSPRPGQWEYANPAEALGPAADRYYDHGFTTRRQLIREVAVDQGALLATARLGIELEEPASPAPRGLESGHGPSITMVDAFVTALQLAQVMLYEMDGVRRQDSDTLWMRQTVMTASGPHRPYEGGVPVTTALTEPDLLRLNGDTWRTMTVVADLAGIEVRSAVTHRLPAGRPSVAAEAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0C4</accession>
    <name>A0A1E7N0C4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557281.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3715"/>
    <dbReference type="EnsemblBacteria" id="OEV34126">
        <property type="protein sequence ID" value="OEV34126"/>
        <property type="gene ID" value="HS99_0011890"/>
    </dbReference>
    <dbReference type="OMA" id="VEDWADQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="11018" checksum="D2CBB6C8026AEC00" modified="2017-01-18" version="1">MTIQIVVTFDLVPERLAPTLAAFQELARHTRREVGALRFDVFRSEAEEHTVVLVEDWADQEAIDLHMKQEYTRAFLAAVDGAFRTPARVHRLAEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D1</accession>
    <name>A0A1E7N0D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1871"/>
    <dbReference type="EnsemblBacteria" id="OEV34148">
        <property type="protein sequence ID" value="OEV34148"/>
        <property type="gene ID" value="HS99_0010665"/>
    </dbReference>
    <dbReference type="OMA" id="DIVHEAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011517">
        <property type="entry name" value="RNA_pol_sigma70_ECF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07638">
        <property type="entry name" value="Sigma70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="17415" checksum="259F6F59B035EB53" modified="2017-01-18" version="1">MLTGSPLAAGDIVHDAYVRIARRPERFLSHPQPYAYVFTTMTNILRDQWRRERRRVALPEVPELAEAVERGRAALDPPHGGTAELQARWEVVRLLGFLTVKQARAVVLVDLDGYSVDEAAELLGLHRSTLAVTRRRAHGRLRAVLERERRHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D5</accession>
    <name>A0A1E7N0D5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0010620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367110.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000898.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1862"/>
    <dbReference type="EnsemblBacteria" id="OEV34142">
        <property type="protein sequence ID" value="OEV34142"/>
        <property type="gene ID" value="HS99_0010620"/>
    </dbReference>
    <dbReference type="OMA" id="ITNCLRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="118"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="367"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="559" mass="60853" checksum="069474F496C52056" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H1</accession>
    <name>A0A1E7N0H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289976.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2350"/>
    <dbReference type="EnsemblBacteria" id="ARF82576">
        <property type="protein sequence ID" value="ARF82576"/>
        <property type="gene ID" value="B6264_02550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34175">
        <property type="protein sequence ID" value="OEV34175"/>
        <property type="gene ID" value="HS99_0011695"/>
    </dbReference>
    <dbReference type="OMA" id="SFYKKDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26357" checksum="6CE0636C4B789602" modified="2017-01-18" version="1">MAEGAPALRLVGLRKRFGGHTAVDGVDLVVPSGSFYGLVGPNGAGKTTALSMAVGLLRPDAGSSAVFGVDVWSDPVRAKALVGVLPDGMMLPERLTGPELLHYLGRLRGLPSATVDARAEELLAVLELDEAGRTPVIDYSTGMRKKIGLATALLHAPRLLVLDEPFEAVDPVSAATIRVILRRFVAAGGSVVFSSHVMALVEQLCDHVGVIAGGRVPAAGPVEEVRAGRGLEEVFVELVGGRTGGEEGLSWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J2</accession>
    <name>A0A1E7N0J2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278478.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1977"/>
    <dbReference type="EnsemblBacteria" id="ARF79577">
        <property type="protein sequence ID" value="ARF79577"/>
        <property type="gene ID" value="B6264_12220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34191">
        <property type="protein sequence ID" value="OEV34191"/>
        <property type="gene ID" value="HS99_0037070"/>
    </dbReference>
    <dbReference type="OMA" id="KLAMEHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35750" checksum="F766068F37E0AF88" modified="2017-01-18" version="1">MSSVAVTGAEGFIGSHLVETLVADGHHVRAMVQYNSFSSFGWLETLSPEVLDSVEIVLGDVRDPGSVNGLVKGTEAVYHLAALIAIPYSYRAPHSYVDTNVTGTLNVLEAVRHLEIPRLVHTSTSETYGTAQTVPITEDHPINTQSPYAASKAGGDRLADSYHASFETPVVTLRPFNTFGPRQSMRAVIPTVIAQVAAGQTEITLGDLRPTRDFMFVKDTANAFRTVGTAPAETVVGRTFNAGTGGEISVGDLVTLVGKLMGVDLLVKEDEQRIRPTNSEVMRLVADATRLREATGWAPLFSLEQGLEQTIEFFRDPANLARYKTDIYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N115</accession>
    <name>A0A1E7N115_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553530.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3920"/>
    <dbReference type="EnsemblBacteria" id="OEV34388">
        <property type="protein sequence ID" value="OEV34388"/>
        <property type="gene ID" value="HS99_0036210"/>
    </dbReference>
    <dbReference type="OMA" id="AVTPCVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="40662" checksum="40BB3DDBE1FF1759" modified="2017-01-18" version="1">MSPARDEFRRSQLAIGALFFVLGFQYATWVSRVPALKARLDLGEAQIGLLLMTCGIGAAVSFPLVAVLMWRLGSRLLSVLSALALGVILMALSVVPDYPVTLLVLFCDGVAVGCLNVAMNAQGAALEARHGRTTMSRLHATFSAGSLLAALLASGVNAFTGTLAVHFGLAALLLAVLVAAARPGLLADAPPEAASREERKKERRGFALPAAATLWMGLAMVFGTVTEGAMNDWSALYLKDVVHAGAGLAPMGIAVVSVMMVCARIFADGWRTRFGDGRIVRTGSLLAGLGLALALLAGGVVPTLLGFACVGLGVAAVTPCVYVAAARQGSDALSLVAAMGTTGLLAGPALIGFIAGGTSLVWGMAAVAASAAVVSLCATRISWPRPQAAPAAQLTPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N171</accession>
    <name>A0A1E7N171_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385623.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1409"/>
    <dbReference type="EnsemblBacteria" id="ARF79240">
        <property type="protein sequence ID" value="ARF79240"/>
        <property type="gene ID" value="B6264_10225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34422">
        <property type="protein sequence ID" value="OEV34422"/>
        <property type="gene ID" value="HS99_0036045"/>
    </dbReference>
    <dbReference type="OMA" id="YEATHEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="593" mass="62952" checksum="DC6526145AEC3900" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N197</accession>
    <name>A0A1E7N197_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene364"/>
    <dbReference type="EnsemblBacteria" id="ARF78933">
        <property type="protein sequence ID" value="ARF78933"/>
        <property type="gene ID" value="B6264_08390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34468">
        <property type="protein sequence ID" value="OEV34468"/>
        <property type="gene ID" value="HS99_0035805"/>
    </dbReference>
    <dbReference type="OMA" id="NDVTHRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="35565" checksum="4BCCA6F32A96DE34" modified="2017-01-18" version="1">MPGAQDSRARVARRIATAAAYGGGGLGLLGVGLVGLLLTESKLAIQAIGVLETVPPKADGVYGEAFADRCAAPQAPLVLAVLGDSTGAGLGVARARETPGALLAAGLASVAERPVRLVNVARSGGRSADLPGQLEQALRHRPDIAVIMIGANDVTRHSPAQVAVRQLGEAVAALRANGCEVVVGTCPDLGTIKPVRPPLRWVARRLSRQLAAAQTIAVVEAGGRTVSLGSLLGPEFAARPEMFAADRYHPSAQGYATAAMAVLPSVCAALGLWPEEERPSAAVPGESVLPVALAAAAAAGRAGTEVAAVEAEGTGRRWALLRHRLRVGAEAPTEPGADPGNTSASSHAGAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1E2</accession>
    <name>A0A1E7N1E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0035420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030596999.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7064"/>
    <dbReference type="EnsemblBacteria" id="OEV34491">
        <property type="protein sequence ID" value="OEV34491"/>
        <property type="gene ID" value="HS99_0035420"/>
    </dbReference>
    <dbReference type="OMA" id="MNTVEFI"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1029"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1111" mass="121395" checksum="7B7E94121298BDB4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L0</accession>
    <name>A0A1E7N1L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77527">
        <property type="protein sequence ID" value="ARF77527"/>
        <property type="gene ID" value="B6264_00035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34578">
        <property type="protein sequence ID" value="OEV34578"/>
        <property type="gene ID" value="HS99_0008735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="34345" checksum="11882CA0E4A0FAB9" modified="2017-01-18" version="1">MPTENKAQNSPKHWQECTGAYDFLEQVRLRPGVWLPGGSLRHLESMLIGYRVALGVHRVEEDFDFWPENSFKEWLWRHLGRHSPLGWAAEIERETPAGSTPVAEFFRLLDTFRAEQDRLAAGRRSLTAPSAAEHPAMQVVRIEIERHDWDAMACGCGHPASGRPGRAELAVPGLNDAPPRRTPAAQPGPRRPPGRRAGSRQPAPQGTPSRGPGPAPCFSRSLGSRWPCSRWNTAATAFMRCHSTARGLNARSSTVWRIRAACRRASICSQSTGDRSAVAGGCSPAPASAAAPSSETCAMACWGWARWARSSVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1N2</accession>
    <name>A0A1E7N1N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3937"/>
    <dbReference type="EnsemblBacteria" id="OEV34383">
        <property type="protein sequence ID" value="OEV34383"/>
        <property type="gene ID" value="HS99_0036295"/>
    </dbReference>
    <dbReference type="OMA" id="RRWRCAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11606" checksum="CC83E133F3FC59A0" modified="2017-01-18" version="1">MTDREIQGLGTEHGDTVGAAVFGVLTVALDVLLLTRIWRWAGEQTASEHRAAAKQTGILIGAVLFAALLGVAIAGQWSTPHRRWRCAMLSALGSHLLLPLGLLLVLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N209</accession>
    <name>A0A1E7N209_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4630"/>
    <dbReference type="EnsemblBacteria" id="ARF81909">
        <property type="protein sequence ID" value="ARF81909"/>
        <property type="gene ID" value="B6264_26180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34729">
        <property type="protein sequence ID" value="OEV34729"/>
        <property type="gene ID" value="HS99_0009595"/>
    </dbReference>
    <dbReference type="OMA" id="PIMATEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="41723" checksum="171A0163A294115F" modified="2017-01-18" version="1">MKITSLETFLVAPRWLFLRIATDEGITGWGEPVVEGRAETVQAAVHELADYLVGQDPLRIEHHWQTLTKGGFYRGGPVLSSAVAGIDQALWDIAGKTYGVPVHQLLGGHVRDRVRVYAWIGGDSPAHVAELAQAQVDAGFTAVKMNGSAQLRPIDTPAQTRAVIDRVAAVREVLGEERDVAIDFHGRMSTAMSRRVLPLLEPLHPLFVEEPVLPEHSRDLRRLVDSTSVPLAVGERLYSRSDFRDVLATGIAVAQPDPSHAGGISEVRRIAALAEVHDVTMAPHCPLGPIALAASLQLAFSIPNFLIQEQSLGIHYNRGNDLLDYLLDPEPFRFTDGHAVRPTGSGLGIEIDEAAVRRAAETGHRWRNPVWHHTDGSFAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N272</accession>
    <name>A0A1E7N272_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557016.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000163.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3247"/>
    <dbReference type="EnsemblBacteria" id="ARF81851">
        <property type="protein sequence ID" value="ARF81851"/>
        <property type="gene ID" value="B6264_25810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34787">
        <property type="protein sequence ID" value="OEV34787"/>
        <property type="gene ID" value="HS99_0009935"/>
    </dbReference>
    <dbReference type="OMA" id="PGRELTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16147" checksum="7C0428B3AFDD7ACB" modified="2017-01-18" version="1">MPTIDESAPVIVRLSTEINAPLERVWSLHTGIDNWPVWNPDIDQARLQGPLTEGTSFTWRTHGMEITSTVHELVPGARIVWGGPAHGIEGVHVWTFEQSGDRVVVRTEESWSGAPVDAATDQLAAALRTSLEDWLTCLKNRAEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N274</accession>
    <name>A0A1E7N274_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556972.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81829">
        <property type="protein sequence ID" value="ARF81829"/>
        <property type="gene ID" value="B6264_25665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34810">
        <property type="protein sequence ID" value="OEV34810"/>
        <property type="gene ID" value="HS99_0010080"/>
    </dbReference>
    <dbReference type="OMA" id="VGCDGTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="490" mass="51911" checksum="19E98485B8CAB91B" modified="2017-01-18" version="1">MLDVLIAGAGPVGLWLAAELRLHGVEVTVVERRAAPDGRSRAVGMQAGTLDTFATRGLAERFIERGTPVSTGHFGAATTRLDFSTVGAVHPFMLALGQSVTEQLLEEHAVAVGARVLRGEEVVSLTQGPDAVEVVIRAGGTHRTVRARWVVGCDGTRSAVRQAAGIDFPGQDTTMTGWLADVELDDPPSAPLAATGPAGSFLVAPIGDGVHRLAGLSTATVHHGTGEPLTLEEVREQARALLGRDLGIRNPRWLSRYGNATRQAARYRAGRVLLAGDAAHMFFPAGGQGMNLGIQDATNLGWKLAATLQGRAPDGLLDSYDTERRPAARAVIDNTRAQLALFAAASPEQIALREVWSAALAEPQTNRQWARRIAGFDDPVPADTASAAHPLDGTRLAGLVLDAAGAPTAHPLMRHGRPLLLDLDGTRTPCSAPGLDQRTVAVNAEDSHPVWRDVTAVLIRPDARIAWAGTDTDPQRRALDCRAALRTLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N280</accession>
    <name>A0A1E7N280_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shy6-polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557020.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000163.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3249"/>
    <dbReference type="EnsemblBacteria" id="ARF81853">
        <property type="protein sequence ID" value="ARF81853"/>
        <property type="gene ID" value="B6264_25820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34785">
        <property type="protein sequence ID" value="OEV34785"/>
        <property type="gene ID" value="HS99_0009925"/>
    </dbReference>
    <dbReference type="OMA" id="ILWGGPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16305" checksum="4EBB8B4F9EA2901A" modified="2017-01-18" version="1">MKNTPSGIDRAAPVVARRELPIRAPAPAVWALLTYVPGWPTWQPDIAVARALTPLTPGAVFHWRTGGVDVTSTVYAVDAPRSILWGGLSQGITAVHEWTFTPSSRATFVVTEESWDGAPVQADADAVTRALDRSLAQWLLHLKSAAERAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I5</accession>
    <name>A0A1E7N2I5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288556.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000839.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5850"/>
    <dbReference type="EnsemblBacteria" id="ARF77560">
        <property type="protein sequence ID" value="ARF77560"/>
        <property type="gene ID" value="B6264_00230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34901">
        <property type="protein sequence ID" value="OEV34901"/>
        <property type="gene ID" value="HS99_0034870"/>
    </dbReference>
    <dbReference type="OMA" id="VHDHERI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="47"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="387"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="473" mass="48668" checksum="139DD9EBF104C509" modified="2017-01-18" version="1">MALLTALQGDHGDAADALRIDGRALSREALLGAATAVADRVAGAPALAVLARPTLETVTAVVGGLLAGVPVVPLPPDSGPKEREHILRDSGAALLAHAAGEAAPDGASVTALPVDPAERSSTTFAEPAPDATGFVLYTSGTTGAPKGAVIRRAAIAADLDALAAAWQWTAEDTLVHGLPLFHVHGLLLGVLGALRTGSRLVHTGRPTPAGYAAAGGSLYFGVPTVWSRLAADQEAAGRLSSARLLVSGSAPLPVPVFEKLAALTGHAPIERYGMTESLITVSTRADGERRPGSVGLPLEGVRTRLVGEDGEPVPYDGESVGELQVCGPTLFSGYLNRPDADAEAWTADGWFRTGDVAVIGADGFHRIVGRASVDLIKSGGYRIGAGEVEAALRDHPAVADAAVVGAPDEDLGQVIVAYVIPDGVVTEEQLTAFVAERLSVHKRPRRVVLVPELPRNALGKVLKKQLLAEAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I8</accession>
    <name>A0A1E7N2I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3232"/>
    <dbReference type="EnsemblBacteria" id="ARF83073">
        <property type="protein sequence ID" value="ARF83073"/>
        <property type="gene ID" value="B6264_25725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34890">
        <property type="protein sequence ID" value="OEV34890"/>
        <property type="gene ID" value="HS99_0010015"/>
    </dbReference>
    <dbReference type="OMA" id="NEWWGGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16817" checksum="D9672E762E22BF30" modified="2017-01-18" version="1">MTIRIAPAAVADFHQVLTDHARYWGERDLRSLHLLALVQEFGSTCLVARAEDGIRGYVFGFVTPEGTGYVHLIATRDDARGTGLGRRLYVAFAEAAERRGARKLKAITSVGNTGSVAFHRSLGFDAEIIDDYDGLGRAMVVFHRDLPLDTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T8</accession>
    <name>A0A1E7N2T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4685"/>
    <dbReference type="EnsemblBacteria" id="OEV35011">
        <property type="protein sequence ID" value="OEV35011"/>
        <property type="gene ID" value="HS99_0034300"/>
    </dbReference>
    <dbReference type="OMA" id="CTGDEHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198690" evidence="1">
        <location>
            <begin position="48"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="19513" checksum="9FF5AD8FA5F21873" modified="2017-01-18" version="1">MKISVRGGSLAAATSLLAVVPLLTGAWAPARAGLAAPVSSTAPVSSAAPVTDATCVLNAHGVFANAVGAGGIDLPLPDTLAMTGTLSCVDAFGAPLATGTFERTVTMPAAECTGDEHGDTSTTTVHWADLSTSTLRFTRTDVVKVNGTASLVVSGAVTADSARFAGDALSAVGTSSGAGCGTPAGETTLDSTLVLRLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U8</accession>
    <name>A0A1E7N2U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4708"/>
    <dbReference type="EnsemblBacteria" id="OEV35029">
        <property type="protein sequence ID" value="OEV35029"/>
        <property type="gene ID" value="HS99_0034415"/>
    </dbReference>
    <dbReference type="OMA" id="EGMAHAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18358" checksum="4B3C5B235D639545" modified="2017-01-18" version="1">MLIVVSGGPGSGKTTLAHALARAVGCPAVCRDEVKEGLLHAGTRVDAPDEAVRDAFFDVLGVLVRAGVSVVAEAAYQDRVWRPRLEPLAARTEVRVVCCRVDPTLARRRIAERLAAGGHRAAHADRELLAAPPGAGNLLDDFTPPSPPGAPRLCVDTTDGYDPPLADIAAFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N363</accession>
    <name>A0A1E7N363_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737920.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene380"/>
    <dbReference type="EnsemblBacteria" id="OEV35115">
        <property type="protein sequence ID" value="OEV35115"/>
        <property type="gene ID" value="HS99_0034220"/>
    </dbReference>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="681" mass="73028" checksum="6DA4189033EA6C41" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N369</accession>
    <name>A0A1E7N369_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285377.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000385.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4435"/>
    <dbReference type="EnsemblBacteria" id="ARF78457">
        <property type="protein sequence ID" value="ARF78457"/>
        <property type="gene ID" value="B6264_05580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35141">
        <property type="protein sequence ID" value="OEV35141"/>
        <property type="gene ID" value="HS99_0033675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="23137" checksum="E87640C20F721144" modified="2017-01-18" version="1">MPVFPEEPEIHESLPGPGVPFPRESDAQALHAPATGGAPATASTTAAAPLPVPGPRPAPPRAAPPRADRQGPPRLIPKPGPAPRRPAPATPQVEVQRIAATPAQALERADDAVDRLLDSGRNPGDVLVLTVGEAHPWQQHELSFGEERYWAQLTEGGDVFYADAALTRPVRREVVVLVVNGGSAARAAEAYGAALGRATALLVVCGEAGPAVAAAAGAAPGRPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N379</accession>
    <name>A0A1E7N379_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator OxyR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene406"/>
    <dbReference type="EnsemblBacteria" id="OEV35125">
        <property type="protein sequence ID" value="OEV35125"/>
        <property type="gene ID" value="HS99_0034100"/>
    </dbReference>
    <dbReference type="OMA" id="DQALDIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="31809" checksum="860EB0347EF94440" modified="2017-01-18" version="1">MAEHRHFREAAAATGTSQPALSGAVAALEESLGAQLVERTTRKVIVTPLGERVHEHARRVLASLQALTEEVEAARRPFTGPLHLGVIPTVAPYLLPTVLRLVRDRFPALELHVHEERTPSLLEGLAAGRLDVLLLALPAGGASPTRDIPLFDEDFVLVTPPGHPLAGRIDVPRDVLLDLDVLLLEEGHCLRDQALDICREVGADPAGSTTRAAGLSTLVQLVAGGLGVTLLPATALDVEAGRTDRLAAVRFAAPAPGRRIGLATRPGSARSAEYERFAAALREVLAELPVRIVDGEGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3G8</accession>
    <name>A0A1E7N3G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289451.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000602.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1371"/>
    <dbReference type="EnsemblBacteria" id="ARF79276">
        <property type="protein sequence ID" value="ARF79276"/>
        <property type="gene ID" value="B6264_10415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35215">
        <property type="protein sequence ID" value="OEV35215"/>
        <property type="gene ID" value="HS99_0033385"/>
    </dbReference>
    <dbReference type="OMA" id="FELETWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24918" checksum="2813CD564FB75B8C" modified="2017-01-18" version="1">MTAAFIDIPGVRNFRDAGGIGALRRGVLYRSGSLHTLTEEGARKLKDLGLRTVVDLRSPFELETWPDQRYGLDHESLNLPTLPANRGDLDRPWPEDQAGLYTFMPETAGPSLSAVIRRLADPEAVPVVVHCAVGKDRTGLTIAVLQSLLGASDADITADFLLSNLGLGLDEGPIPYIDETGSERLSRPVAAEHIAASLDWIRTQHGTVPGYLYSHGLTDADLDALRANLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H9</accession>
    <name>A0A1E7N3H9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366653.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1357"/>
    <dbReference type="EnsemblBacteria" id="ARF79287">
        <property type="protein sequence ID" value="ARF79287"/>
        <property type="gene ID" value="B6264_10500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35225">
        <property type="protein sequence ID" value="OEV35225"/>
        <property type="gene ID" value="HS99_0033465"/>
    </dbReference>
    <dbReference type="OMA" id="ANPQNGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="PTHR40631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="811" mass="86485" checksum="E1991A5BE904CC20" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J8</accession>
    <name>A0A1E7N3J8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="9">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metG</name>
        <name evidence="12" type="ORF">HS99_0033570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289512.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000384.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6134"/>
    <dbReference type="EnsemblBacteria" id="ARF79307">
        <property type="protein sequence ID" value="ARF79307"/>
        <property type="gene ID" value="B6264_10605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35244">
        <property type="protein sequence ID" value="OEV35244"/>
        <property type="gene ID" value="HS99_0033570"/>
    </dbReference>
    <dbReference type="OMA" id="YMRMAGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="4"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="11">
        <location>
            <begin position="418"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="343"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="572" mass="63872" checksum="7E539101E837E395" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T0</accession>
    <name>A0A1E7N3T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828204.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2434"/>
    <dbReference type="EnsemblBacteria" id="OEV35346">
        <property type="protein sequence ID" value="OEV35346"/>
        <property type="gene ID" value="HS99_0032525"/>
    </dbReference>
    <dbReference type="OMA" id="TATWDVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="33128" checksum="7F8F58A4F61205A3" modified="2017-01-18" version="1">MDQRTELSEFLRSRRARLRPEDVGLPGGTTRRRVPGLRREELAQLAGVSTAYYTRLEQGHGENVSAAVLDAIARVLRLGPAERDHLGRLTKPARRRPGGTGPTRPQRVRPALQQLLDTMESVPAYVLGRRLDIIAWNRLGAALLGDFAAMPPEQRNIAWHVFLDPAARELFEDWETKAGDVVGLLRLDAGRYPDDRGLASLIGELSVKSEDFRSLWATYRIQDKGHGTKRLHHPVVGPLSLQYETLRPAGDADQVLVAYHAEPGSPSAESLRLLASWDATELRPEPADRAGRVAEQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3T8</accession>
    <name>A0A1E7N3T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550623.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2420"/>
    <dbReference type="EnsemblBacteria" id="OEV35356">
        <property type="protein sequence ID" value="OEV35356"/>
        <property type="gene ID" value="HS99_0032595"/>
    </dbReference>
    <dbReference type="OMA" id="WIVNWFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="34737" checksum="9E0DE395236925DF" modified="2017-01-18" version="1">MKINGITYDTGTPTVDGSVTRPGLTAATMRRELAAVAGELYCTAVRITGDDVTRMRQAAETAIGLGLAVWLSPMLPNADEAATLGAVAAAAEVAGELHRAGGDVTLVVGCELSAFMTGLVPGTDIAARLAALADPMSWPPEYFAAGPPPVRFNALLATAVATARKHFDGPVTYAAGLWEDVDWTPFDLVAVDAYRDAANAATLRTTLEALHGHGKPVVVAEFGCAAFTGAADHGALAWTLVDRTDGVRRPRPGLVRDEAAQAAELTSLIELFTAAGLAGAFVFTYVTPAYPASDDPREDLDTVGYGLVRSWPDGRTTPKAAFGAVARAYAPPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3X7</accession>
    <name>A0A1E7N3X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386206.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2435"/>
    <dbReference type="EnsemblBacteria" id="OEV35401">
        <property type="protein sequence ID" value="OEV35401"/>
        <property type="gene ID" value="HS99_0032520"/>
    </dbReference>
    <dbReference type="OMA" id="YRFSIDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="13"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="38439" checksum="EF5AC8446BEFD087" modified="2017-01-18" version="1">MTNETTQSTTPTGTTRTVAAYAAPRPKAPLAKTTVTTRAAGEHDIVIDIKYSGICHSDIHQVGEDWGSGTFPMVPGHEIAGVVAEVGPGVTRWQVGDRVGVGCFVDSCRECDNCRAGLQQYCQGEGGMVFTYNDTGRDGRPTYGGYAAELVVDEAYALRIPDALPLDAAAPLLCAGITLYSPLAHWGAGPGKKVAIVGLGGLGHMGVQLAHAMGAEVTVLSQSLRKREDGLRLGADHYRATSDPTTFEELAGSFDLIVNTVSADLDLTAYIGLLRTDGTMVQVGVPEKPVSLHPFPLAIGRRSLAGSAIGGLPETQEMLDFCAEHGITARIELIRAEQINEAYRRVLDGDVRFRFVIDASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N412</accession>
    <name>A0A1E7N412_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278707.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2426"/>
    <dbReference type="EnsemblBacteria" id="OEV35404">
        <property type="protein sequence ID" value="OEV35404"/>
        <property type="gene ID" value="HS99_0032565"/>
    </dbReference>
    <dbReference type="OMA" id="WGMWAVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23357" checksum="30C1F4FA6E50AEB4" modified="2017-01-18" version="1">MHIDAWIESVPPTAVYALIGLIIGLESLGIPLPGEVALVTATLMAVKGVVSPWGIAACAIAGAIIGDSIGYSIGRKGGKPLFEKLGRKFPKHFGPSHLATAERSFQKWGMWAVFFGRFIALLRIFAGPLAGALKMPYWKFLIANVLGGVIWAGGTTLLVFKVGKAIEPWLSRFSLVALAAAVVVGATSAWLMKRRAAKTHAKIEAEEAAKAAEALKAPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N442</accession>
    <name>A0A1E7N442_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000950.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1620"/>
    <dbReference type="EnsemblBacteria" id="OEV35442">
        <property type="protein sequence ID" value="OEV35442"/>
        <property type="gene ID" value="HS99_0032295"/>
    </dbReference>
    <dbReference type="OMA" id="TGIGHMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="30056" checksum="7AA0CC64EEF8585A" modified="2017-01-18" version="1">MSPSPSDDADRPTVLAHLSDLHLDDGPRAEERVRRMVRYLVELPGEIDAVLITGDIADRGTEEAYVRTRAVLAPLYERFPVLVCPGNHDEARALRRILLDGGGEGEGTGDGAPVDQVRDVAGTRIVLCDSSVPGRADGLLRPQTLRWLDETLAEAPDRPTLVALHHPPAELGLPYIDGIRLREADRFAAVLRRHPQVAGVLCGHAHTMAVTRFADLPLVCAPGVASSALMPWEQEPGQLWKTLDAPPALAFHVLRNGRLTSHARTVLGDVRTRPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C9</accession>
    <name>A0A1E7N4C9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="10">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0033185</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550023.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000810.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5330"/>
    <dbReference type="EnsemblBacteria" id="ARF80737">
        <property type="protein sequence ID" value="ARF80737"/>
        <property type="gene ID" value="B6264_19125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35313">
        <property type="protein sequence ID" value="OEV35313"/>
        <property type="gene ID" value="HS99_0033185"/>
    </dbReference>
    <dbReference type="OMA" id="EMHPQAR"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004620">
        <property type="entry name" value="MTHF_reductase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00676">
        <property type="entry name" value="fadh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="6 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="33650" checksum="CA2750E16083B6A7" modified="2017-01-18" version="1">MALGIASTRPDRALTVRELLAAGKRSFSFEFMPPRTEVGEQKLWDAIRRLEPLDPNFVCMTYGAGGSSRERTVNMVGRIATETTLTPVAHLTAVDHSIAELRNIIGQYADQGVRNVLAVRGDPPGDPMGEWVRHPEGVTYAYELVELIKGIGDFCVGVAASPNMHPRSTDWDEDIRHFTAKIRSGADYAITQMFFEVDDYLRFRDRVTAAGCETPIIPEIMPVTNAKQLERFPQLSGSAFPANLEARLRAVVDDPAALRAIGMEHATAMAERLLAEGAPGLHFITLNHSTATLEIYQNLGLHQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5H0</accession>
    <name>A0A1E7N5H0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386573.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7274"/>
    <dbReference type="EnsemblBacteria" id="ARF81105">
        <property type="protein sequence ID" value="ARF81105"/>
        <property type="gene ID" value="B6264_21305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35894">
        <property type="protein sequence ID" value="OEV35894"/>
        <property type="gene ID" value="HS99_0008530"/>
    </dbReference>
    <dbReference type="OMA" id="QPWAGRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="27270" checksum="FD36AA91F24A1206" modified="2017-01-18" version="1">MDRKDFSNPAFVGKSIPNPGFSDDDGTADPALTAALARWSQDRTAEPEVLAALTPTRLMVPIVAILGEVEVDDHGHRHDKSSDMAVPVLEAPDGRRALPAFTSLESLTRWRADARPAPTAAPQAAMVAFSERADTLLVDPAGPVPFLLSGARLRALAENRPYLPPARDPEVREAVRALLAAEPQVLSGLLAPSEDSDGVLAVVFDPALDQPGLQAAAQRVGEAVAGDPLLRVRLDRGLDLAVLPASAQLPGEPLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V8</accession>
    <name>A0A1E7N5V8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0030935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386284.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4963"/>
    <dbReference type="EnsemblBacteria" id="ARF80031">
        <property type="protein sequence ID" value="ARF80031"/>
        <property type="gene ID" value="B6264_14915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36087">
        <property type="protein sequence ID" value="OEV36087"/>
        <property type="gene ID" value="HS99_0030935"/>
    </dbReference>
    <dbReference type="OMA" id="FRMNLFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="40308" checksum="D5E07E6990990A9C" modified="2017-01-18" version="1">MTSPNPAAKRSFAQRISGERIVLALAAPVLAVVLSVAICSVLLATSGKNPFDAWNVMITYATKSDGQVLILNRATTYYLAAAAAAFGFRMNLFNIGVEGQYKVAALFAAFVGAQVDLPAFIQIPLLLVTAMLIGGLYASIAGLLKVYRGVSEVISTIMLNAISVSIVGLLLVPGVFAPKASSTSNSIQTDPVSDSSHFFSIPTAGGDLWGFLFIAVLVGVLFQFTLTRTRFGFDLRATGRSESAATASGVNVKKMVVISMVVSGAIAGLIGLPELLQNSYSYGQSFQPGLGFLGISIALLGRNSPIGMAFAALLFSFLDSTGSQLPLKGGFPFEIVAVMQGTIVICVVVAYELVRRYGLKRQQQKVGAQLAAQAAATEKKEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y4</accession>
    <name>A0A1E7N5Y4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553169.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4994"/>
    <dbReference type="EnsemblBacteria" id="ARF80061">
        <property type="protein sequence ID" value="ARF80061"/>
        <property type="gene ID" value="B6264_15070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36116">
        <property type="protein sequence ID" value="OEV36116"/>
        <property type="gene ID" value="HS99_0031090"/>
    </dbReference>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="20493" checksum="DE883EF155A79C10" modified="2017-01-18" version="1">MTDQRALVLASASPARLGLLRQAGLDPRVVVSGVDEDAISAATPGELALVLAEAKAKAVAAGLTDGELVIGCDSVLELDGRALGKPADAAEALARWQSMRGRDGVLRTGHCVIDTATGKQASATASTTVRFGTPDDEEVAAYVVSGEPLHVAGAFTLDGRSAPFVDGIDGDPGNVIGLSLPLLRRLLAELDLRITDLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N663</accession>
    <name>A0A1E7N663_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366720.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000538.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8102"/>
    <dbReference type="EnsemblBacteria" id="OEV36180">
        <property type="protein sequence ID" value="OEV36180"/>
        <property type="gene ID" value="HS99_0030490"/>
    </dbReference>
    <dbReference type="OMA" id="GGRNLWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198802" description="GP-PDE domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="45"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="29644" checksum="41FC2A2127C73439" modified="2017-01-18" version="1">MTAPPRAARTAALAALAVLAAGCAAGGGPALQARSAVAPAVCASPVVIGHRGAPFNAPENTMASFETALDQGADWLETDVQTTRDGVPVLMHDPTVDRTTNGKGAVADLTAAQVAALRVTVGPGPAQSVPTLEELLERLSGSSATLLMEIKWQRPEDVARIARIAAGSKAHVVLYSFSVDHLRQAHAVAPALPVVLIQSGGIAEDPKGLKLNGIALDTGLATAARIAAERKAGREVYVWTLDGEEAWQLMTARDADGLITDTPGPARRWVDANCRTERRTGPRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N676</accession>
    <name>A0A1E7N676_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284343.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8103"/>
    <dbReference type="EnsemblBacteria" id="OEV36179">
        <property type="protein sequence ID" value="OEV36179"/>
        <property type="gene ID" value="HS99_0030485"/>
    </dbReference>
    <dbReference type="OMA" id="DTCEARY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="45715" checksum="7BC937E2072A1E42" modified="2017-01-18" version="1">MISRAQAVEAGHRWINGDLPQGAGAVRRVCAHEFELGWVVWAEPPRVEVDPRTGERRAPGEVGAACAVVDRESGRFTVWPSVPVDEVVGLYRDFVGAGGYDPTGPPVTGRGARAELTYRDGTGATHALALRSAAGLPHPALRGWWWLREQGIPAEDVLAVRTDLRLSALPGGYWSYALAAELPHARLEFELPYGPRSDHRAAAVRQLPAPPDGPGRNRVPFPRAVPPLPGESDAALAERLVRRFGTAGVQRFGPADTARAELPGDAAALLLSVGVPKAVDGFFALHHPGAEAIADGSRPGTVLPPLAPHLAALGRGTRVAERERSALAGQLVLGTDGWALITLDTGPGAVRAVDPDYGTARHCNADLRAFVRCLELFAGWWPTLRGLDPAAAGAAVDALQRGLAELDGTVYGDPENWWAVIVEQLWDGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H6</accession>
    <name>A0A1E7N6H6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000349.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2642"/>
    <dbReference type="EnsemblBacteria" id="OEV36278">
        <property type="protein sequence ID" value="OEV36278"/>
        <property type="gene ID" value="HS99_0030180"/>
    </dbReference>
    <dbReference type="OMA" id="RCIVMIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="224"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="44112" checksum="95EB7405D0A5D078" modified="2017-01-18" version="1">MKLTGLWDHADFRRLWAGQTLSMLGTNMVAVAVPLIASVSLGASVFQMGLLLATEFLPYLLISLFVGVWLDRRPKKMIIVAADAVRSLILLSVPLLSWAHLLSVPLLLAVVFGTGACSTVSDIGNASILPALVEREDLVEGNSKLEMSSSVSNIGGRTFGGLLVQLLTGPVVIMVNVFAFGLAAACTLRIRKREPVPEKPATGDPSSMWKEIGEGLGFIFGDATLRTLVLVTFLVNFSAIAIDPVFLVFITRTLDLPGILVGALLAGTGVGSLMGALIAARLGKALPFGRMVIWTTVAMTAVELVIPAATVMPKGVAFAMLMFVQVAYAVLVIASAVNIRSYRSAITPDAMQGRMNASTRMIVMAGTPFGAMVGGALGSWLGTQLAIVVCAGGIGLAALLLALSPVRTATGIPTEVPEPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P8</accession>
    <name>A0A1E7N6P8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="5" type="ORF">HS99_0031185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5013"/>
    <dbReference type="EnsemblBacteria" id="ARF80078">
        <property type="protein sequence ID" value="ARF80078"/>
        <property type="gene ID" value="B6264_15165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36133">
        <property type="protein sequence ID" value="OEV36133"/>
        <property type="gene ID" value="HS99_0031185"/>
    </dbReference>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="40427" checksum="ABE430494C9DB412" modified="2017-01-18" version="1">MSTRTTVITGIGSLVTNDPGHGTGPLGLLTDAAVVIDGDTVAWVGPAAQAPAADERFDAEGRALLPGFVDSHAHLVFAGDRTAEFNARMSGQAYSAGGIRTTVAATRAASDAELEANLAGFVREALRQGTTTIECKSGYGLTVEDEARALRIAAKHTPETTYLGAHIVAPEYAEDPAGYVDLVTGEMLDACAPHARWVDVFCEKGAFDGDQARAVLTAGIERGLTPRVHANQLTYGPGVQLAVELGAASADHCTHLTDEDVAALAGSATVATLLPGAEFSTRAEYPSGRRLLDAGAVVALSTDCNPGSSFTSSMAFCIAVAVREMGMTPDEAVWAATAGGAHALRRSDVGVITAGARADLLLLDAPSHVHLAYRPGVPLTAAVWREGVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R4</accession>
    <name>A0A1E7N6R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387254.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000773.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4893"/>
    <dbReference type="EnsemblBacteria" id="ARF82376">
        <property type="protein sequence ID" value="ARF82376"/>
        <property type="gene ID" value="B6264_29005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36334">
        <property type="protein sequence ID" value="OEV36334"/>
        <property type="gene ID" value="HS99_0029655"/>
    </dbReference>
    <dbReference type="OMA" id="CYTFFKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="30155" checksum="51AFE0F8568BB7F4" modified="2017-01-18" version="1">MTTETLTTGTVAAEATAAEADSHPAPYVHGYSDSEAQRLGDQADTLAELLHAGTVYPAGSRVLEAGCGVGAQTAHLLAASPGVLLTAADVSAESLAQARARIAGVAPSARVVWHHGDLHRLPFPDGTFDHVFLCFVLEHLPDPAAGLAALRRVLRPGGTITVIEGDHGSAFFHPETPAARRTIDHLVRLQAGAGGDALLGRRLYPLLTAAGFADVTVRPRTVYADGGCPALVDGFTLRTFVAMVEAVRAEALAAGLTTPEAFDRGIAELRGAAGPGGTFHYTFFKAVAVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C8</accession>
    <name>A0A1E7N7C8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7926"/>
    <dbReference type="EnsemblBacteria" id="ARF82724">
        <property type="protein sequence ID" value="ARF82724"/>
        <property type="gene ID" value="B6264_09430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36607">
        <property type="protein sequence ID" value="OEV36607"/>
        <property type="gene ID" value="HS99_0029155"/>
    </dbReference>
    <dbReference type="OMA" id="KAYGVVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="46481" checksum="D0A3C5C99272636B" modified="2017-01-18" version="1">MVRTASTVGLSAGKLVHGTGRRIRRATSAEGAGESGLAKLIELHALNSFGDMLITIALASTIFFSVPTGEARGRVALYLLITMAPFALLAPVVGPLLDRLPHGRRAAMAMSMLARAVLAWTMAGVISGGGIALYPEALGVLVASKAYGVVRSVVVPRLLPSRLSLVKANSRVTLAGLLATGVAAAVGGALHLIGPGWPLRGAFLVFVIGTLMAFHLPHTVDSAKGEQRAVLHADLPGEGQGPHLIHHRPPKVKASLRTVGPSVVLALRAMSGMRWLVGFLVFFLAFLLRTDPIGGLQPTLALGLVALSAGTGNALGSVLGSWLRTRGPEATVTAMLLLATCATAAAALWYGVVTVVLVAGVSGIAASLGKLALDALIQRDVPEAVRTSAFARSETLMQLSWVAGGGVGIVLPLDGVLGLSIAAAVVGLVLVWTGHSLLRLGLRRHPAAPRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M4</accession>
    <name>A0A1E7N7M4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2480"/>
    <dbReference type="EnsemblBacteria" id="ARF81518">
        <property type="protein sequence ID" value="ARF81518"/>
        <property type="gene ID" value="B6264_23710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36690">
        <property type="protein sequence ID" value="OEV36690"/>
        <property type="gene ID" value="HS99_0028425"/>
    </dbReference>
    <dbReference type="OMA" id="GWAGATM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="22353" checksum="DB124C1186381925" modified="2017-01-18" version="1">MTSHPAVRTPQQDRSRATRARLLAAAVDCLAELGWQGSTVSVVAERAGVSRGAAQHHFPTREDLFTAAVEHVTAERLAAVRTHADELPAAGPDRTRAVVDMIVRLYTGPLFRAALHLWTAAATEEALRERIIALEGHVGREAHRAAVEFLDADESRPGVRESVQATLDLARGLGLANLLTDDSVRRSGVIRQWAGVLESTLRPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T7</accession>
    <name>A0A1E7N7T7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552948.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000433.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36739">
        <property type="protein sequence ID" value="OEV36739"/>
        <property type="gene ID" value="HS99_0027330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="16103" checksum="2683FDE4A05C8BFD" modified="2017-01-18" version="1">MPGAGEAGEGAKVGEAGAAGDRVVLPDGRLLPAGPGDAPGTSLPRWTERGNAEQAVTAPAVRFSADGVHWAFTEWSGTGLRTTVGAESGAECGAAFTAVVPGVTAPPAHVCSHAGCGHRLAPRRTGVRRTGGRFGAAGRPGSHGGLTMAFEAATRRPERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D8</accession>
    <name>A0A1E7N8D8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287032.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6833"/>
    <dbReference type="EnsemblBacteria" id="ARF78626">
        <property type="protein sequence ID" value="ARF78626"/>
        <property type="gene ID" value="B6264_06605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36928">
        <property type="protein sequence ID" value="OEV36928"/>
        <property type="gene ID" value="HS99_0027085"/>
    </dbReference>
    <dbReference type="OMA" id="KGPYKDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="590" mass="63542" checksum="5E8B8C55D678FE44" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L0</accession>
    <name>A0A1E7N8L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556176.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81691">
        <property type="protein sequence ID" value="ARF81691"/>
        <property type="gene ID" value="B6264_24810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37035">
        <property type="protein sequence ID" value="OEV37035"/>
        <property type="gene ID" value="HS99_0004195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12315" checksum="86446B4542403E58" modified="2017-01-18" version="1">MACTTLDGIPAAVTASADTTVRVWDLRTSQTIGDPLIGHTGRVTAVACSMLNGMPAAVTASADKTVRVWDLRTGTATAVVALSAPYGVALTTTGDLVVAFQSDIALYRRQRYDGTAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N939</accession>
    <name>A0A1E7N939_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556653.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6219"/>
    <dbReference type="EnsemblBacteria" id="ARF81571">
        <property type="protein sequence ID" value="ARF81571"/>
        <property type="gene ID" value="B6264_24065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37164">
        <property type="protein sequence ID" value="OEV37164"/>
        <property type="gene ID" value="HS99_0004925"/>
    </dbReference>
    <dbReference type="OMA" id="PATWVGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="23149" checksum="9A365744F9884A48" modified="2017-01-18" version="1">MGHAVGDVLGLAAGIAVSPLPIVAIILILATPRGRLNGLLFALGWVLGLAALGALMLAVGGTGGASTHKNPATWVGALKLALGALLVVFGARQWRRRPKDASQAQLPKWMTAIDGFTPIKILGLALLFSAGNLKNAPLTIAAGASISSSGLPATQQVVTLVIFVVIASLGVLAPLVVYLVMGERAKSILRSWRDWAAQHNVAVLAALFFVFGLKLLGDGISILAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R0</accession>
    <name>A0A1E7N9R0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000680.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6199"/>
    <dbReference type="EnsemblBacteria" id="ARF83033">
        <property type="protein sequence ID" value="ARF83033"/>
        <property type="gene ID" value="B6264_23960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37430">
        <property type="protein sequence ID" value="OEV37430"/>
        <property type="gene ID" value="HS99_0005025"/>
    </dbReference>
    <dbReference type="OMA" id="QCCFLAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7449" checksum="2285C9C23972CB23" modified="2017-01-18" version="1">MRTVVDLTRCQGYAQCVFLAPEVFELHGEEGLLYATAVPDDQVERVRQAAAACPVQAILLGEEVSTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9S7</accession>
    <name>A0A1E7N9S7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1291"/>
    <dbReference type="EnsemblBacteria" id="OEV37447">
        <property type="protein sequence ID" value="OEV37447"/>
        <property type="gene ID" value="HS99_0005620"/>
    </dbReference>
    <dbReference type="OMA" id="QCHFGQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21943" checksum="E9DD8FFDFAE9B88A" modified="2017-01-18" version="1">MGAKVTGTDIADDAIDIARGLATELDLDANFVQANLYDLPKVLDGQFDMVFTGYGTLSFLPDIAGWAKIAAQYVKPGGTLTIVEIHPILTLFGDVDGELRVARSLFQSRDVHHEMSATYADRIEDEVEVETHSIYGWRWTIEEVLNSLIDAGLTIERVREVPYDARQRLPLMVPDGDHNWRIQGDPIPLSFACVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9W9</accession>
    <name>A0A1E7N9W9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552677.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7955"/>
    <dbReference type="EnsemblBacteria" id="ARF79087">
        <property type="protein sequence ID" value="ARF79087"/>
        <property type="gene ID" value="B6264_09290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37486">
        <property type="protein sequence ID" value="OEV37486"/>
        <property type="gene ID" value="HS99_0026065"/>
    </dbReference>
    <dbReference type="OMA" id="GRIQFIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="22990" checksum="B1353487813E8303" modified="2017-01-18" version="1">MQKFATPTPVSVVLDIPAGRIRFIAADRTDTVVEVRPADATKSRDVKAAERIEVRYADGVLRIQAPEAENRLLGNSGTAEVTVQLPVGSRVEAKAALGEFRGVGRLGDVTLRAAQGTVKLDETAGAHLTLQAGDIAVGRLGGPAEIRTQKGDLQIAEAVGGDVTLRTEYGQIAVGAARGISAALDAGTGHGRIHNALRNADGTPGLTIHATTGYGDITARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD8</accession>
    <name>A0A1E7NAD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280751.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1689"/>
    <dbReference type="EnsemblBacteria" id="ARF79922">
        <property type="protein sequence ID" value="ARF79922"/>
        <property type="gene ID" value="B6264_14315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37665">
        <property type="protein sequence ID" value="OEV37665"/>
        <property type="gene ID" value="HS99_0025525"/>
    </dbReference>
    <dbReference type="OMA" id="AGFCVHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="44985" checksum="D3FB66197B2594ED" modified="2017-01-18" version="1">MKNPIAKLLGVLPPGARLVVGGTVVLGASAYVYMALVGYSLSTVGAARVTMLWTIVMSVGWGLFQPVELELTRLVAARKVAGHGALPAVRRMLLLAMAILVAVCGVLAVAARPIADQLFSGDRSLVVALAGGLAGLAVSSVARGALAGLGLFGPYGTQLAVDGGLRIGLAGVAAAVGLHSAMAFGLILFVSPLLASLIGLRDTLADRTPGPEVSWKQLTGGLGLLIASVMLSQLVVNATVVCVRLLSPKHSEASDALVFAIGQAVVMARAPLFAYSALQASMVSALSGAAAAGNHAEFRKVLTRTTAIVAAMCIGGGLPVIVLGSRLNPLLFNAKDVLGPLDFVWLVFGTLCYVLATVFGQALMSSAQHRRQLVGWTAGSVALVAVALAPGDVGLRAELAYLAGSLVSAVLMLWSLYRAFPSRPAAVPSDRSAAEPLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL5</accession>
    <name>A0A1E7NAL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000498.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8010"/>
    <dbReference type="EnsemblBacteria" id="ARF82827">
        <property type="protein sequence ID" value="ARF82827"/>
        <property type="gene ID" value="B6264_14000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37737">
        <property type="protein sequence ID" value="OEV37737"/>
        <property type="gene ID" value="HS99_0025215"/>
    </dbReference>
    <dbReference type="OMA" id="LSADYWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="16364" checksum="5446ED0753EDDB9D" modified="2017-01-18" version="1">MSYELQALMGTLELLTVAAAEVPAARVVPLAQGLALIPLTSAVLSALQGDAAVPKPAGGAGFGWHSDGFELRIAAWSKAGPIACVEAEYFGGSGTQRAAVWSDGRVVLGPLTSGDSEPSPAEGTPISRALRCLGGHVEPGRADEFDSVGLGAHRSTAGWATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM6</accession>
    <name>A0A1E7NAM6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0025900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553127.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4920"/>
    <dbReference type="EnsemblBacteria" id="OEV37732">
        <property type="protein sequence ID" value="OEV37732"/>
        <property type="gene ID" value="HS99_0025900"/>
    </dbReference>
    <dbReference type="OMA" id="PSWWRDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="474" mass="50052" checksum="EF46AE0CE55F7E93" modified="2017-01-18" version="1">MTEDPRIQEAGPAAPPEPERPPLTRTEHHRVVAGVCGGLGRHLDIDPVVFRVVTVVLCLSGGLGLFLYGLAWLIVPTEDGADGKGRGGRTELQRVLTGRVDGQSIGAVLLTVIGTGVFFSSMDDGDQMFPLLLLGGLVFLAVRYDPERRRGRGRGRRHGGPYDRHFPDDDGPGRPQDEAARARHAAAQAAGTAPADSPAPGPSGYLWDPRHPERNPYGAADPAGPTPAYGTKVPPPGGPAQPWWQRTDLPEGDPLRKERPERRREPAAVRQPRDRSPLGFFGFLLAIGAAAAVWSASVGHTDVTKLSTVVLATGLLVIGLTLLLAARFGRARRLAVLGLLTTLVLAFTGHAPHTVQDAIGDRTWTVGSAAELKDRYNLGAGNVRLDLSGLDPAGSTLATKVDLGAGELVVTVPPNVTVNLVTRVGLGNVTVPGDRNDGTGRHVYRIDPVGGQPSKGTLDLQLGLGLGDIKVVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB06</accession>
    <name>A0A1E7NB06_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0023690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278232.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2139"/>
    <dbReference type="EnsemblBacteria" id="ARF79436">
        <property type="protein sequence ID" value="ARF79436"/>
        <property type="gene ID" value="B6264_11355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37886">
        <property type="protein sequence ID" value="OEV37886"/>
        <property type="gene ID" value="HS99_0023690"/>
    </dbReference>
    <dbReference type="OMA" id="DPDYRYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="708" mass="74636" checksum="615D1EAFCAF2EB91" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB28</accession>
    <name>A0A1E7NB28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6037"/>
    <dbReference type="EnsemblBacteria" id="OEV37868">
        <property type="protein sequence ID" value="OEV37868"/>
        <property type="gene ID" value="HS99_0024905"/>
    </dbReference>
    <dbReference type="OMA" id="WAAWLIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="43865" checksum="1CFD65695B5EEA27" modified="2017-01-18" version="1">MVAVAGMLSFVAMLDMNIVNIALADVADGFHISAQTAQWAVLGYQLPLVALLLPAGRWLDAVGTRPAVLTAVAGFALGSVAAAAAPWAGALIAARVVQGAFGAVLFVLMPVLAMRSVRPQLRARVMSVPATLGPLGAVTGPALGGLLLDHFGWRAIFLVKLPVCLAAWLLARRHVPAGGVLRAPGRAELADAGLIGGSVAAVLLGLTLSADSVAWLLLAAPALPLVLWWLRRGGGRPVLAVLRENRTAGLNTAVLAVAAAFAVVHYLLALHLQRDEAESATATGLTILCFPLAMGIGGPLGGRLADRFGARSTATAGVALTAFGFLLLVPLGDSWSLPDVAWRLALAGAGMGLYGGPTQTLVMSAATPATTATASSTVQLARSLGFTLGPALATASWSLGGPGAAGLHTGIGLAAAGACLAVVLLASHGRPAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBD0</accession>
    <name>A0A1E7NBD0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0024005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552076.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2079"/>
    <dbReference type="EnsemblBacteria" id="ARF82775">
        <property type="protein sequence ID" value="ARF82775"/>
        <property type="gene ID" value="B6264_11675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38016">
        <property type="protein sequence ID" value="OEV38016"/>
        <property type="gene ID" value="HS99_0024005"/>
    </dbReference>
    <dbReference type="OMA" id="VDHVHPT"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="39441" checksum="FA988D5DE03067D4" modified="2017-01-18" version="1">MSWSRARETARRAGLRPLPVVDLPLAGALGHVLAEPLGALTDLPAFDTSAMDGWAVAGPGPWRVAGRVLAGRTEVAPLADGSAVEIATGAQLPPGATAVLRREHGRTEGTLLRERGPEKLTTGQDVRPRGQECRRGEELLPAGTVIGPAVLGLAAACGHDRLAVRRRPVVQVLVLGDELLDSGTPGPGLVRDALSPLLPPWLHAAGAEVAEVRRVRDDFGLLRDALRYSTADVVVTTGGTAAGPVDFLHRALAEVGARLLVDGVAVRPGHPMLLAELPGGRHLVGLPGNPLAAVAGMVTLALPLLHARSGRAAFGPAPAPAAVLLPGHPVDTRLQPVRRTAEGVVPLAFDGPAMLRGLARAEALAVIPPGGAAAGEVVELVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBG6</accession>
    <name>A0A1E7NBG6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1999"/>
    <dbReference type="EnsemblBacteria" id="OEV38027">
        <property type="protein sequence ID" value="OEV38027"/>
        <property type="gene ID" value="HS99_0024405"/>
    </dbReference>
    <dbReference type="OMA" id="GMLACWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="224"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="448" mass="46498" checksum="374AB4A1B476F2F9" modified="2017-01-18" version="1">MLGPADAPEDGTDGTAAPSATVQDRLAGRLSDITSLHEHTERLAHARGLAATLDAVLASGAALLGADRGVLVTLMPGGGPGQPVGLGLDRASLGALETVPTEQSLLARLLGEDDRPEQLHSPDLAEDPAVGGRLRELAVQLGLGGAVGLPLATVEDGPLAAVVWFYDRPAEPTGCQRELARRYCEFAAPLLAKQLEVERIRRTTEALRRGLLPDHLPRAAGLRLAARVVPAGLDHSSGSDWYDAIPLPDGTVGLTVGSVFGDGPGAGPGSAPGAAAAMGRIRAALRAYAVLEGEDPVSVLGDLELLLKTTEPTRTATAVYAWVEPGERRVTLAGAGHCPPVLVGRHGAEFVETSLSAPLGMLACWEAPGIEFTADRGDTLLLYTEGLARRCGPTLHAGQANLRRAAADAPRDVRIDPDRLCAHLLAVCPVPDAAPATDDLMLLAARFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC70</accession>
    <name>A0A1E7NC70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558052.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1740"/>
    <dbReference type="EnsemblBacteria" id="ARF80229">
        <property type="protein sequence ID" value="ARF80229"/>
        <property type="gene ID" value="B6264_16095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38254">
        <property type="protein sequence ID" value="OEV38254"/>
        <property type="gene ID" value="HS99_0022185"/>
    </dbReference>
    <dbReference type="OMA" id="AWESFTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="30450" checksum="A3345A00025A4D2A" modified="2017-01-18" version="1">MTKILVIGANGSVGRHVVASLTEGGHEVRALVRNAAEAALPVGVEAVEGDLAAPESLAAGLSGGVQAVYLMWPGIPVQPRVVELIAEHAERVVYLSTDVPDLADDEPPVIFHQEIERLIRRSGLAWTFVRAIDFAGNVLGWAGQVREGLVRWPYGQARRSLIHERDIADVAVRALIEDGHEGAKYLVTGPESIAHADLARIIGEELGTEVRWAELAPETAREQLTAAWGNAAFVESRLRAWESFTREPERVTATVEQVLGRPARTFRSWVRDHAEDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC79</accession>
    <name>A0A1E7NC79_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290703.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80225">
        <property type="protein sequence ID" value="ARF80225"/>
        <property type="gene ID" value="B6264_16065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38258">
        <property type="protein sequence ID" value="OEV38258"/>
        <property type="gene ID" value="HS99_0022210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="13656" checksum="BEBC26A3EC151D7C" modified="2017-01-18" version="1">MLTKKIATAAVAVAAAGVLATATSASASTTLYNTGTATVGAGLSNTCTSRTVNLAAGSYGWGFYDSAPYVSSTITVAAGSYTWTDCLAVSVDYDFLNSTLQLNGSTSAPKTLRASRWLSQGTHTYGSFLKPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC96</accession>
    <name>A0A1E7NC96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553289.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4196"/>
    <dbReference type="EnsemblBacteria" id="ARF80199">
        <property type="protein sequence ID" value="ARF80199"/>
        <property type="gene ID" value="B6264_15900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38284">
        <property type="protein sequence ID" value="OEV38284"/>
        <property type="gene ID" value="HS99_0022370"/>
    </dbReference>
    <dbReference type="OMA" id="HIPPWTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26856" checksum="43F0B0BF51DB1E85" modified="2017-01-18" version="1">MKLTVVGCSGSFPSADSPCSSYLVEADGYRVVLDLGNGALGALQKYTSLYEVDAVLLSHLHADHCVDLCAYWVARNYRAEGCPDLLPVYGPAGTAERLARAYDMPENPGMKEVFEFRTLTPGSFELGPFRVSVTQVNHPVDAFAFRLEHGGRSLVYSGDTGESPALVELARDTDLFLCEAAYLDGRDTYQAVHLNGREAGEHATAAGARRLVLTHIPPWTDAERNRRDAAATYAGPVELARAGAVYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ2</accession>
    <name>A0A1E7NCJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82212">
        <property type="protein sequence ID" value="ARF82212"/>
        <property type="gene ID" value="B6264_28025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38397">
        <property type="protein sequence ID" value="OEV38397"/>
        <property type="gene ID" value="HS99_0021030"/>
    </dbReference>
    <dbReference type="OMA" id="QAIWANT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="24191" checksum="5B454032AA21F8BF" modified="2017-01-18" version="1">MPGMENQQPSERPTGLQAIWANTLEPVAPLPRYRTVPRKAWIAGGVVVALFAALTVAAVTGAGAPPSHRIVLADRIGDQERTPDDKVVTTERARLHRALTALRPYRDVSVAGYGPAGSGRRSLLVAGMTGSFPDARGELDRQFGAGWGSDVSRWPDNEPIRERQDHPAGPLGGALDCAVLGDSATSRTICIWADGTTVGAVIDGTGETRPDDLAKRALEIRTAVEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND23</accession>
    <name>A0A1E7ND23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase subunit CobN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551461.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene618"/>
    <dbReference type="EnsemblBacteria" id="ARF77634">
        <property type="protein sequence ID" value="ARF77634"/>
        <property type="gene ID" value="B6264_00715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38606">
        <property type="protein sequence ID" value="OEV38606"/>
        <property type="gene ID" value="HS99_0020300"/>
    </dbReference>
    <dbReference type="OMA" id="WETGQAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1209" mass="129943" checksum="DB2164812C5F53E1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH6</accession>
    <name>A0A1E7NDH6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1810"/>
    <dbReference type="EnsemblBacteria" id="OEV38731">
        <property type="protein sequence ID" value="OEV38731"/>
        <property type="gene ID" value="HS99_0020785"/>
    </dbReference>
    <dbReference type="OMA" id="AVWGYGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199028" description="OmpR/PhoB-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="22840" checksum="2C4519D00027252B" modified="2017-01-18" version="1">MRAVRSVPSLSAIPSTAPAVPGPSGSPVVGPSRPGAVPSAGPQPGAVVPPAPASLLAALPEGATVVAALPQGALPQGLLAQYGAQAGGPAGHPMVGYLVLVPAENPTPAPGGLPGAGAAGAVRPVRPAGRGITVDAERRNAYVDGRLLDLTYLEFELLAHLTEHPQRVHTRDHLVSAVWGYGHVGDGRTVDVHVARLRRKLGPTYRDSIVTVRRVGYKYTPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDW3</accession>
    <name>A0A1E7NDW3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0019560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5144"/>
    <dbReference type="EnsemblBacteria" id="OEV38862">
        <property type="protein sequence ID" value="OEV38862"/>
        <property type="gene ID" value="HS99_0019560"/>
    </dbReference>
    <dbReference type="OMA" id="VGGFWTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="41493" checksum="7B0B5CC59231FDA2" modified="2017-01-18" version="1">MQTTTPLSPEDPPEIGGFELLARIGQGGMGQVYLGESPGGEQAAVKVIKPSLVDSETRLRFAQEIEILKTVWGNRVAAFLDADPEAEPPWLATEYVEGADLRRHVDAYGPLPAVLVASLGATLAEALALVHKQGLLHRDLKPANVLLGPTGPKIIDFGLAVFAESGSSLTAPNTVVGTPMCMAPEQANGVKPLTEAVDAYALGAVLLFALTGRYPYQAANINVLFHMVTDRDTPPDLAGVPAELSPILASMLAHEARDRPSLPSVVQEFRAVIETQGLKVAQARRRLTALTAARPAPGPGSTTQTVQLLQPAPADATTVPAPAPTVAPPPGPAPDENPGYTPTLRDVPAVTTSPTDAPGPTPAPPSASAPRTPRRSLQARRTAQQLREVYAAKAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE01</accession>
    <name>A0A1E7NE01_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555433.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000178.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6509"/>
    <dbReference type="EnsemblBacteria" id="ARF81282">
        <property type="protein sequence ID" value="ARF81282"/>
        <property type="gene ID" value="B6264_22385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38875">
        <property type="protein sequence ID" value="OEV38875"/>
        <property type="gene ID" value="HS99_0019650"/>
    </dbReference>
    <dbReference type="OMA" id="AEMYANE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="30149" checksum="E8149E51CDE61ABB" modified="2017-01-18" version="1">MSTPDVPTVPSVKLNNGVEIPQLGFGVFQVPDDETTAAVGSALEAGYRSIDTAAVYGNETGVGRALAASGLARQDLFVTTKLWNADQGYDATLRAFDASLTKLGLDHVDLYLIHWPAPARDLYLDTWRALERLAAEGRIRAAGVSNFQPAHLQRLLDTSELVPAVNQVELHPGLQQAELRAFHARHGIATEAWSPLAQGAVLDDPAVTAVAGRTGRSPAQVVLRWHLQLGNIVIPKSVTPARIRQNLDVFDFELTEQDMAAIAATDRGLRTGPHPDQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE95</accession>
    <name>A0A1E7NE95_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557314.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4324"/>
    <dbReference type="EnsemblBacteria" id="OEV38965">
        <property type="protein sequence ID" value="OEV38965"/>
        <property type="gene ID" value="HS99_0017795"/>
    </dbReference>
    <dbReference type="OMA" id="MHLILSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30385" checksum="6D8161DBA314D90E" modified="2017-01-18" version="1">MNGDLETDHDVLVTLARFTLATAEQLHQLHGGQAGLKQTQKRMARLHEEGLAEFVTLPQAGRAKAWHLTGQGAATAATFPEARRPGHQAAPAEQAALRYGRGHLLDLGRVHTAFVADARARGEGCGPLDLIPAPEHPAGPTGEVYRPAAEIAYTATTTGGRRRLRAFVELHRPGGGTEHTVEQLAACASLWEQPGAGGSGRAWERRWRAFPSVLVVLAGTPAAAIDAAVADLRLAAEERPAVAELLAAVPTGAARLEDLVQHGPAAPVWHPLGTEGQRPCGWTQLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA1</accession>
    <name>A0A1E7NEA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557536.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83260">
        <property type="protein sequence ID" value="ARF83260"/>
        <property type="gene ID" value="B6264_30440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39029">
        <property type="protein sequence ID" value="OEV39029"/>
        <property type="gene ID" value="HS99_0018170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="24205" checksum="D155C428AECE0EAA" modified="2017-01-18" version="1">MTTAPATAAEALTGLARIRPAGWLATPMPTDPVDLLVRARQALAADHPGVTGRVSVLSARYTAAVFAVHRSPPEGSLVLKLPDDPAAYAGETLAYALLSDTAPVARLYAEGEDSLSLLLEYLPEAADWSGPQMPALLVERVVAVLTASLRLSDEAAEASHSPSCGAPRPRPGWRTRARTARCWPRTWTPTARTWCHWATSTSSLNTCTGARTARWCCSTWRACART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEE7</accession>
    <name>A0A1E7NEE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83314">
        <property type="protein sequence ID" value="ARF83314"/>
        <property type="gene ID" value="B6264_30790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39081">
        <property type="protein sequence ID" value="OEV39081"/>
        <property type="gene ID" value="HS99_0018510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15761" checksum="79A078C9CE0ED9C0" modified="2017-01-18" version="1">MSVLRSKIALLSATVGLAAGTVALATPASADVITGEGDQGLCTYRVCMSYYGSGNGAWFRSNYPEVTDLAGWQFGRGAFNNSYQWSGDGLPVKNAAAWIVNTGSQDIYVYVNSKAYGWGAYDLVYPGHGGNLQVTRNNEASYSTTPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEN2</accession>
    <name>A0A1E7NEN2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285078.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3466"/>
    <dbReference type="EnsemblBacteria" id="OEV39160">
        <property type="protein sequence ID" value="OEV39160"/>
        <property type="gene ID" value="HS99_0000030"/>
    </dbReference>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17493" checksum="13C02766448FE1E0" modified="2017-01-18" version="1">MSLYDIPLRTLAGEATSLAEHKGKALLIVNVASKCGLTPQYTGLENLQKRYAGRGFTVLGFPCNQFAGQEPGSAEEIQSFCSTTYGVTFPLFEKIDVNGDDRHPLYQQLTEVADAEGQAGDVSWNFEKFLISPDGTVAARLRPRVEPESAEAIAAIEAVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF23</accession>
    <name>A0A1E7NF23_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ORF">HS99_0000910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737758.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3647"/>
    <dbReference type="EnsemblBacteria" id="OEV39306">
        <property type="protein sequence ID" value="OEV39306"/>
        <property type="gene ID" value="HS99_0000910"/>
    </dbReference>
    <dbReference type="OMA" id="ILLCPCG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13601" checksum="A4CB785B2B64A5EB" modified="2017-01-18" version="1">MHELSIALSVVEAVEEFAAGYPGERVEEVRLRVGALAGVEAEALDFSFAVVCEGTALAGARLAIEHVPAVVRCRPCEREFAVRPPLDLRCPACGGGSVECASGRELEIAAVVLGTAEGADEREVAGDVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK8</accession>
    <name>A0A1E7NFK8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5079"/>
    <dbReference type="EnsemblBacteria" id="OEV39486">
        <property type="protein sequence ID" value="OEV39486"/>
        <property type="gene ID" value="HS99_0001980"/>
    </dbReference>
    <dbReference type="OMA" id="NGENWFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199087" description="SBP_bac_5 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="79"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="53767" checksum="1D5AC2493616DA85" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM9</accession>
    <name>A0A1E7NFM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550244.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3631"/>
    <dbReference type="EnsemblBacteria" id="OEV39293">
        <property type="protein sequence ID" value="OEV39293"/>
        <property type="gene ID" value="HS99_0000830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="3">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="42114" checksum="9EB780AE070CE38D" modified="2017-01-18" version="1">MPGPAHIAMVNIPAHGHVNPSLEVIRELVSRGHRVSYVNDPSFAEQIEATGARFVPHETGLSVLKGAVEPGTNVHSMIFDEAQAMLPLMREVFEDDRPDLVLYDFMAYAGRVLADSWGVPSMLISPSRVATADPEVEPFRTVMKALEAENVPERFTQWLADNGVPPRDIFTYMLRPDRGIALIPQALQTGLAEIDPEVFSFAGPCLDNRGRDGSWTRPQDAQKVLLVSLGSTFTHQPAFYRACLEAFGDLPGWHVVLQIGRSTDPAELGPIPANVEVHPWVPQFAVLQQADAFITHAGMGGCSEGLYCGLPMVAVPQAADQFENADRLVELGVARRLDTDLATADALRSAVLELTEDPKVADRLAELSAEVRAGASVARAADLVEAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFP0</accession>
    <name>A0A1E7NFP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0002165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481224.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5042"/>
    <dbReference type="EnsemblBacteria" id="OEV39516">
        <property type="protein sequence ID" value="OEV39516"/>
        <property type="gene ID" value="HS99_0002165"/>
    </dbReference>
    <dbReference type="OMA" id="REPWANE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="146"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30618" checksum="E9E75E760AC9D1EE" modified="2017-01-18" version="1">MVDPVIVGVDGSGRSLRALVWAASDAARRECPLLIAHVLPAWEFDFPFFPPGRSQGLSRRGAEILAEAVAIAKESHPGLEVESDQVSGSPAEVLRAATERACCMVLGARGEGGLGNLLMGSVSLQVAGHAACPVVVVGEIATGHGRVLVGTDSSEHSTAALEFAFEEASLRGVRVHSLRAWSMPTKPEPSEDGPGPDEVEAEQRRQLDDQLAPLRHRYPDVEIETTLVRGKPVTELVRASDRADLAVVGSRGKGGFHGLALGSVSHGLLHYGICPVAVERPPQPRHTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG01</accession>
    <name>A0A1E7NG01_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Ribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araB</name>
        <name evidence="7" type="ORF">HS99_0002925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ribulokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2779"/>
    <dbReference type="EnsemblBacteria" id="OEV39639">
        <property type="protein sequence ID" value="OEV39639"/>
        <property type="gene ID" value="HS99_0002925"/>
    </dbReference>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="298"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="565" mass="60096" checksum="9EF2D28B4D6FB49E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG26</accession>
    <name>A0A1E7NG26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367053.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2731"/>
    <dbReference type="EnsemblBacteria" id="OEV39598">
        <property type="protein sequence ID" value="OEV39598"/>
        <property type="gene ID" value="HS99_0002685"/>
    </dbReference>
    <dbReference type="OMA" id="APFERVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="18700" checksum="0349444C08FBDD33" modified="2017-01-18" version="1">MTDSPTPMPQWPVADFDPVRRLHVIAATAPGAARIGETVLGAPFERVWALAQDLERTMPLWIPDVRTVRLDRPAPSGSLPTTSLRARIHGHTRLRATFGIDLAPGWCLMQSRLVLGGMAARPETDRTTRFAFLGGLRFPGARLLAPALRPFTGDPLARFAALLEEEQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG82</accession>
    <name>A0A1E7NG82_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279476.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2889"/>
    <dbReference type="EnsemblBacteria" id="OEV39729">
        <property type="protein sequence ID" value="OEV39729"/>
        <property type="gene ID" value="HS99_0003470"/>
    </dbReference>
    <dbReference type="OMA" id="LESCTYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="126"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="31509" checksum="59168859CB445ACB" modified="2017-01-18" version="1">MRYTEAADPDCAISQALAVVGDTWTLLLIRDVAGGTHQFDALQNGLGISRKVLTERLKALVADGVLEKRLYHPHPPRYEYHLTDRGRGLLPVLVALQDWGGRYVLGDGTLTGTSTPDSAETRRVLALTGHRLPALELAAASGGWTDPVAADRAWTVLYCYPGAYAPGTMGHPPGWGEIPGAPGCTLESCTYRDRMGEFAARDTAVHGVSTQRPDQLAAFADHARIPFPLLSDAGLELAAALRLPTFRAAGAERLKRLTLILDADRTVRGALYPVPDPAGSVEDVLSLLDGLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF7</accession>
    <name>A0A1E7NGF7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ORF">HS99_0000415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480322.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3546"/>
    <dbReference type="EnsemblBacteria" id="OEV39790">
        <property type="protein sequence ID" value="OEV39790"/>
        <property type="gene ID" value="HS99_0000415"/>
    </dbReference>
    <dbReference type="OMA" id="AFMAHPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="31878" checksum="5A94A07788BF18DC" modified="2017-01-18" version="1">MRLLTVHAHPDDESSKGAATLARYAAEGVDVLVATCTGGERGSVLNPALDRPEVRADLTRIRREEMDAAREILGVRQQFLGFVDSGMPGPDEPLPEGCFAAQPLEVAAAPLVALIREFRPHVVITYDETGGYPHPDHVMTHKVAVEAFEAAADPKRHPGAGEPWQVAKLYYHLALSRAWFQTLHDAMTERGVASEMGELLAGWPDTPPALATTTRIECAEQFAVRDAAMLAHATQVQPGVAFMAHPRDIEREVWPTEDYHLARSFVSGPGNPVPTAGAVGAVENDLFAGVRAAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NHC0</accession>
    <name>A0A1E7NHC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0002880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2770"/>
    <dbReference type="EnsemblBacteria" id="OEV39853">
        <property type="protein sequence ID" value="OEV39853"/>
        <property type="gene ID" value="HS99_0002880"/>
    </dbReference>
    <dbReference type="OMA" id="FDVWNKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="41971" checksum="08F413FE45B4525D" modified="2017-01-18" version="1">MADSARNGAESDPSPSVGSVLARALRGNVRQYGMLVALALIVLLFQIWTDGILLQPLNITNLIQQNGYILILAIGMMIVIIAGHIDLSVGSLAAFVGAAAAVMMVEHHMPWPVAMLVALVIGALAGAWQGFWIAYLGIPSFIVTLAGMLLFRGGTQILLQGQSVAPFPKGFQSISSGFLPEVGPHTDYHNLTLLLGLAVLVVAVLQELRGRRQTASYGLEVLPLGLFLAKLAVITAAVVVFTLLLASYHGVPIVLLILGALLVGFGYLMRNSIIGRHTYAIGGNEAAAKLSGVKSKRVVFLAFTNMGVLAALAGLVFAARLNAGTPQAGINFELEAIAAAFIGGASASGGVGTVLGAIIGGLVLGVLNNGMSLVGVGTDYQQVIKGLVLLAAVGFDVYNKRRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP6</accession>
    <name>A0A1E7MWP6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289949.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene79"/>
    <dbReference type="EnsemblBacteria" id="ARF80125">
        <property type="protein sequence ID" value="ARF80125"/>
        <property type="gene ID" value="B6264_15430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32862">
        <property type="protein sequence ID" value="OEV32862"/>
        <property type="gene ID" value="HS99_0039745"/>
    </dbReference>
    <dbReference type="OMA" id="QAYRRGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="414" mass="42383" checksum="2B5DBE41BF74FD70" modified="2017-01-18" version="1">MLDDTLLDDPAALQRADHDRALLALAGAGARVRTALRQADTAGLDRLRPDGRPRAVLVAGHGSALTAAEILAVLAGSATLVAPLPPTEAAAPRADRAGAPPAFTAGLGWQLPGWAGPLDLLVVSSADGGEQGLISLAEQAYARGCAIVVTAPAGSPLAGAALQVRALPLPYVAAVLPDEGAPAVPAAEPDLPAEDPAALWSHLTPLLALAQKLGLTQLPYDALPAVADLLDATAVRCRPDAAAYTNPAKGLAARLAGTVPLLWAEGPVAAAAAARFAAQLADRAGRPALAGSLPQALTAHRGMFTGQWGAGADPDDFFRDRVEEPDPLHLQVLLLRHVPGTGPAEEQDGPAEVTEDDPRPRSFGVTRAHRLAAAHEVRLTEYASTLPEQLHALADLIALTDFAAVYLGLAAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWU5</accession>
    <name>A0A1E7MWU5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0013590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366904.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6554"/>
    <dbReference type="EnsemblBacteria" id="ARF81322">
        <property type="protein sequence ID" value="ARF81322"/>
        <property type="gene ID" value="B6264_22605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32912">
        <property type="protein sequence ID" value="OEV32912"/>
        <property type="gene ID" value="HS99_0013590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="7">
        <location>
            <begin position="460"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="858" mass="92596" checksum="41F20BC8CF8D327D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ4</accession>
    <name>A0A1E7MWZ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0013835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5753"/>
    <dbReference type="EnsemblBacteria" id="ARF81370">
        <property type="protein sequence ID" value="ARF81370"/>
        <property type="gene ID" value="B6264_22865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32957">
        <property type="protein sequence ID" value="OEV32957"/>
        <property type="gene ID" value="HS99_0013835"/>
    </dbReference>
    <dbReference type="OMA" id="HLANVIS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="490" mass="48909" checksum="53D98AA5E1B3D54D" modified="2017-01-18" version="1">MSGLALAASGALAVPTVTSAAAVGYPVVHPAVADYSQVSTGTTPPTPAQCASAGRRCFSPQGIRAAYNLGPLYANGFDGRGQTIAIFDSYGSDTMAHDLHVFDQAFGVNAMCGEEGVACQPGMPTFSELHVQGDPGTTAPPSTSRGTGQESKAAWALEVALDVETAHAMAPGANILLVSTPTAETLGVQGLPALMNAEQYVVDHHLANVISQSFASAEGALASSQSIEPLRHAFKSAALNGVTVLGSSGDNGTAGSVKTPVKSGGSTLPYPSVEWPASDPLVTGVGGTFLCTDPGATAGRTVDSTDNPAACRTNVGAAEVGWSGSGGGFSQVFDKPGYQSALPAGSTAIGARRGVPDVALQASPGTGALVYLSLPPDGSSGLKCGATPCSTGWYDIGGTSLSCPQWAGLVSIADQINGGGLGQINPALYKLATDPAAYAADFDDVTLGNNTTDPTVPGYSATTGWDPITGLGTPNAAKLLPDLVSAAHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX51</accession>
    <name>A0A1E7MX51_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552468.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5694"/>
    <dbReference type="EnsemblBacteria" id="ARF81425">
        <property type="protein sequence ID" value="ARF81425"/>
        <property type="gene ID" value="B6264_23160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33007">
        <property type="protein sequence ID" value="OEV33007"/>
        <property type="gene ID" value="HS99_0014130"/>
    </dbReference>
    <dbReference type="OMA" id="AGPWLTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="744" mass="77723" checksum="09F94C0FC4DFB422" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX71</accession>
    <name>A0A1E7MX71_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="12" type="ORF">HS99_0014290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279804.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5662"/>
    <dbReference type="EnsemblBacteria" id="ARF81454">
        <property type="protein sequence ID" value="ARF81454"/>
        <property type="gene ID" value="B6264_23320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33038">
        <property type="protein sequence ID" value="OEV33038"/>
        <property type="gene ID" value="HS99_0014290"/>
    </dbReference>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="30468" checksum="D2A4C4EE98F57987" modified="2017-01-18" version="1">MLRIAVPNKGSLSGPAAEMLHEAGYRQRKDPKELVLVDPNNEVEFFFLRPRDIAVYVGSGRLDVGITGRDLLLDSHSNAEEVLALGFAGSTFRFARPEGVDVKDVKGLEGLRIATSYTGLVEQHLADHGVKATVTKLDGAVETAVQLGVADVIADVVETGTSLRNAGLEVFGEPILISDAVVIRPKGAGEDARVDQFLRRLQGVLVARRYVLMDYDIRAEKVGAAVALTPGLESPTVSPLHTEGWVAVRSMVLRKEAQQIMDDLWGIGARAILVTNIHACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX99</accession>
    <name>A0A1E7MX99_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279734.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81482">
        <property type="protein sequence ID" value="ARF81482"/>
        <property type="gene ID" value="B6264_23505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33066">
        <property type="protein sequence ID" value="OEV33066"/>
        <property type="gene ID" value="HS99_0014475"/>
    </dbReference>
    <dbReference type="OMA" id="MAFFWFL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="10524" checksum="9D17116B3292FA2E" modified="2017-01-18" version="1">MDLLTYKELDTGPDAPRNPSRGQRAWHWLLSLSPTVVTFMVALSIGLCMVAVQTGWDPMLGLMAFFWFLTFIALVGMVARWVTPGRGRHRMAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC6</accession>
    <name>A0A1E7MXC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5600"/>
    <dbReference type="EnsemblBacteria" id="OEV33087">
        <property type="protein sequence ID" value="OEV33087"/>
        <property type="gene ID" value="HS99_0014600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="27444" checksum="7505B3737719521F" modified="2017-01-18" version="1">MSSGEAVPRRRNPRGQGQALKVELVEAAARLLATLERPETLTLRQVAREVGVAPASIYGHFADLGALVQHVLRLRYDELAAVMHAAAQGADDPLADLVGRCAAYVHWGVDHPGEYRTLFGGGMPAELVPTNAHGAGEELLGSVVASLASVRQERPGRREGQEGQGPRGPEQEWQAGLLLWTALHGLVALYNAHGNMPWPDLTDLIARTLALHTGRTVDEVAELARAAHREPPGSVPTRGSMSAAHPSTNPPNPPTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS4</accession>
    <name>A0A1E7MXS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385849.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000141.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000092_gene530"/>
    <dbReference type="EnsemblBacteria" id="OEV33248">
        <property type="protein sequence ID" value="OEV33248"/>
        <property type="gene ID" value="HS99_0039030"/>
    </dbReference>
    <dbReference type="OMA" id="MYLKRPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="234"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="37238" checksum="F4C1BDBDAF89E2F4" modified="2017-01-18" version="1">MQNPTSREQRVEKRLIVVVLFEGVDLLDVTGPPEVFSLVRRETADAAGYRVVLAAATTDPVTTAAGVRILPDLTFDQAAAAGGIDTLLVPGAVEADGGRVRALTDPAVVDHVRTLAARARRVASVCVGAHLLAAAGLLDGKRATTHWSTAGQLAAEYPQIEVDADPIFIREGEVWTGAGISACLDLSLALVAEDFGEELALRVARQLVMYLKRPSGQSQFSVPLEPVSTTRRIEELRHHILRNLSDRLTVPDLAAHAHVSERQLVRIFKAELGTTPSAYVESARVELARHRLESGDDTLERIATACGFGTTDTMVRAFRRRLDTTPTDYRRRFRTSTPPPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY04</accession>
    <name>A0A1E7MY04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6794"/>
    <dbReference type="EnsemblBacteria" id="ARF78592">
        <property type="protein sequence ID" value="ARF78592"/>
        <property type="gene ID" value="B6264_06415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33291">
        <property type="protein sequence ID" value="OEV33291"/>
        <property type="gene ID" value="HS99_0038840"/>
    </dbReference>
    <dbReference type="OMA" id="TKPHKYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="21426" checksum="72DA6057CB7C39E5" modified="2017-01-18" version="1">MSIAPYPDWIRPPAGGYTAEDLDRLPDLPPHTELIDGSLIFVSPQTAFHMRTLRRLERALETAVPEGWDVWREMTVRLDRRNRPEPDLLVVDERGVTGPKQTFCDARDVLLAVEVVSEESQQRDRDTKPRKYAAAGIRHFWRVESDDDGRPVVYAYELDPATGYVVSGIYHKQLKVDQPFPVEIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYD0</accession>
    <name>A0A1E7MYD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287531.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000343.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3954"/>
    <dbReference type="EnsemblBacteria" id="ARF80534">
        <property type="protein sequence ID" value="ARF80534"/>
        <property type="gene ID" value="B6264_17905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33429">
        <property type="protein sequence ID" value="OEV33429"/>
        <property type="gene ID" value="HS99_0012680"/>
    </dbReference>
    <dbReference type="OMA" id="EYVYLEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007427">
        <property type="entry name" value="DUF475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04332">
        <property type="entry name" value="DUF475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="39327" checksum="06A249D0BC93C956" modified="2017-01-18" version="1">MFLRTFGWSFAITAVGLIAAGLLWGAQGFGIVLILSILEISLSFDNAVVNATVLKRMNPYWQKIFLTVGVLIAVFGMRLVFPLLVVGLTAKLNPATVIDLALHSDKTHDGLTYGQYLEAANPAIAAFGGVFLLMIFLDFVFDEKEHNWLGWLERPLEKVGKLDALSSVVALVALVLASRFFAAEHAETVLLAGVLGLITYLAVSGLSSIFESGLEEEAEREEEAEKSGKSVVQVAGKAAFFLFLYLEVLDASFSFDGVVGAFAISNDIFQITLGLGIGAMYIRSLTVFLVRKGTLDDYVYLEHGAHYAIGALAVILLVGIKYHIPEIVTGLIGVAFIGLALASSMMRNRREAPEDEKELVGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ4</accession>
    <name>A0A1E7MYJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33506">
        <property type="protein sequence ID" value="OEV33506"/>
        <property type="gene ID" value="HS99_0013165"/>
    </dbReference>
    <dbReference type="OMA" id="HGYQIIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13760" checksum="C3E3F07D18391B44" modified="2017-01-18" version="1">MHGYEMIAEITERTNGAWRPSPGSIYPNLQLLEEEGLITAEEVGGKRLVSLTEAGRAVAESGPAEPWAEAGREVDWEAVQEVGQALAAVDQAVQQVMRTGTEAQRAKGLAVLTEARKKLYLILAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ7</accession>
    <name>A0A1E7MYJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5190"/>
    <dbReference type="EnsemblBacteria" id="ARF80615">
        <property type="protein sequence ID" value="ARF80615"/>
        <property type="gene ID" value="B6264_18430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33512">
        <property type="protein sequence ID" value="OEV33512"/>
        <property type="gene ID" value="HS99_0013210"/>
    </dbReference>
    <dbReference type="OMA" id="SSNMCWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6460" checksum="719C5970D4F1F27C" modified="2017-01-18" version="1">MPRTSLFALLVVVLALAAAVVSVVQGFWLGLIWLPLAGVASNVLWMNRRRAKLAEAAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ1</accession>
    <name>A0A1E7MYQ1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0013495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282683.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000708.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5248"/>
    <dbReference type="EnsemblBacteria" id="ARF80667">
        <property type="protein sequence ID" value="ARF80667"/>
        <property type="gene ID" value="B6264_18715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33562">
        <property type="protein sequence ID" value="OEV33562"/>
        <property type="gene ID" value="HS99_0013495"/>
    </dbReference>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="470" mass="52332" checksum="504AFE3A47FAE4EF" modified="2017-01-18" version="1">MFNNAAEVKQYIQDNDVKFVDVRFCDLPGVMQHFSVPAATFDPSETLMFDGSSIRGFQAIHESDMALVPDLATARLDPFRAEKHLNINFFIQDPVTGEAYSRDPRNVAKKAEAYLASSGIADTAFFGPEAEFYVFDSARFETSANASFYHIDSEAGAWNSGAAEGDVRGYKVKYKGGYFPTPPVDHFADLRAEMSLELAKSGLEVERQHHEVGTAGQAEINYKFNTLLHAADDLMLFKYIIKNVAWRNGKTATFMPKPIFGDNGSGMHVHQSLWSEGSPLFYDEQGYAGLSDTARYYIGGLLRHAPSLLAFTNPSVNSYHRLVPGFEAPVNLVYSQRNRSAAIRIPITGSNAKAKRIEFRAPDPSSNPYLAFSAMLMAGLDGIRNKIEPLEPVDKDLYELAPEEHANVPQVPSSLPAVLEALEADHEYLLAGNVFTPDLIETWIDFKRTNEIAPIALRPHPHEFELYYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT6</accession>
    <name>A0A1E7MYT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6605"/>
    <dbReference type="EnsemblBacteria" id="OEV33597">
        <property type="protein sequence ID" value="OEV33597"/>
        <property type="gene ID" value="HS99_0012900"/>
    </dbReference>
    <dbReference type="OMA" id="GSDFPNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="30"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="33212" checksum="7895CB5E43C6B798" modified="2017-01-18" version="1">MSSEPGARVSSEEAAAVREFWQSLGLPGLVDVHTHFMPKNVLDKVWAYFDAAGPLVNRPWPITYREAEEQRLQRLRDFGVRAFTSMLYPHKPGMANWLNAWAADFAARTPDCLHTATFFPEPGAAGYVARAVEEGARVFKAHLQVGGYDPTDARLDEVWGLLADTGTPVVTHCGSGPVPGKFTGPGPIGAVLDRHPGLVLVVAHLGMSEYRDFLDLAERHPAVRLDTTMAFTDFAEADDPFPRDELPRLRGLRERVLLGSDFPNIPYRYVHQLEALAGLGLGEEWLRAVCHDNAAALFQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYW5</accession>
    <name>A0A1E7MYW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6310"/>
    <dbReference type="EnsemblBacteria" id="OEV33622">
        <property type="protein sequence ID" value="OEV33622"/>
        <property type="gene ID" value="HS99_0038660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="7194" checksum="96ECC9A38A002DCB" modified="2017-01-18" version="1">MAGSSSDITHTCAALPATAIPWAASGTGTGPVPVSPEDDRAYGCSTWDGSQRFVDTPVAAPPAPGAPPRSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ5</accession>
    <name>A0A1E7MYZ5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0038535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286430.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1099"/>
    <dbReference type="EnsemblBacteria" id="ARF82707">
        <property type="protein sequence ID" value="ARF82707"/>
        <property type="gene ID" value="B6264_08690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33656">
        <property type="protein sequence ID" value="OEV33656"/>
        <property type="gene ID" value="HS99_0038535"/>
    </dbReference>
    <dbReference type="OMA" id="AGNHHPW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="592" mass="65539" checksum="8C8CC2E5D5CB1571" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW7</accession>
    <name>A0A1E7MZW7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2205"/>
    <dbReference type="EnsemblBacteria" id="ARF77834">
        <property type="protein sequence ID" value="ARF77834"/>
        <property type="gene ID" value="B6264_01840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33976">
        <property type="protein sequence ID" value="OEV33976"/>
        <property type="gene ID" value="HS99_0010995"/>
    </dbReference>
    <dbReference type="OMA" id="RCDSELA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="48784" checksum="8B6FC115C1175116" modified="2017-01-18" version="1">MHVTGTHFTDRTEAGHRLAARLAHLAGPDTVVVALPRGGVPVAAEVATALDAPLDICVIRKLGVPYQPELAMGAIGEDGVRVLNEQVLRLAGVSDEQLARVEGRERTELARRARRYRGDRPASDLRGRTVVVVDDGIATGSTAKAACRIVRARGAARVVLAVPVAPLDWTDRLSEVADELVCVDTPSPFFAIGEFYADFSQTGDEEVLRLLAEARGRVGHGNGRQEEPPDGVDRELLLSVAGVRLAGRLTVPAGARGIVVFAHGSGSGRHSPRNRHVARYLNRAGLGTLLFDLLTEAEEPDRRKVFDVGLLGSRLTAVARELERTDGARGLPLGLFGASTGAAAALYTAAELGPAVRAVVSRGGRPDLAGPDVLGRVDAPTLLVVGALDTTVLDLNRQARARLRGANELAVVPHASHLFEEPGTLDQAAELAGDWFLRHLPVTDGSPTTGPATDRRDADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N001</accession>
    <name>A0A1E7N001_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2243"/>
    <dbReference type="EnsemblBacteria" id="ARF77862">
        <property type="protein sequence ID" value="ARF77862"/>
        <property type="gene ID" value="B6264_02020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34005">
        <property type="protein sequence ID" value="OEV34005"/>
        <property type="gene ID" value="HS99_0011175"/>
    </dbReference>
    <dbReference type="OMA" id="ERWMVRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="31031" checksum="89BAD7513F5D3E5B" modified="2017-01-18" version="1">MAWVETDAGGYRVALDEEGRVVCRNAAGRALKSVPSKLGDDPVVTQLKQLAEWLAAHERRCQEDVERWMVRSLPVPAAVLAAVWPDEAWRAVLRDVVVTGPDGAVAGFLRDADAERGLGLVDLDGDTVRLTDGEVLIPHPVLLPDLDDLREFAVELGVSQRVQQLYREVWHRPDEPSAGTEVTTYAGGRYRELRELVGRCTRLGCRVRGGSAVQPITEGGRTVEARVWVGDYYEYDACETGALSWAGPDGRALPLAEVGPVAWSEGMRTAAALYAGRTIEGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N073</accession>
    <name>A0A1E7N073_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551882.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000805.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77950">
        <property type="protein sequence ID" value="ARF77950"/>
        <property type="gene ID" value="B6264_02530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34090">
        <property type="protein sequence ID" value="OEV34090"/>
        <property type="gene ID" value="HS99_0011675"/>
    </dbReference>
    <dbReference type="OMA" id="YRLENDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15198" checksum="230A0B0540943C81" modified="2017-01-18" version="1">MGGAEDEAWDAEAAERAVAVLKAVADPSRYRLLWALSRRELPVSELAELLGAHVAATSQHLAKLRAAGLVVARREGTRIFYRAAEVRGLLTEAAVIANDLPARGADRGGDGGAAPAAATVEQPFARAARAVRGVRRRPVTDRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G9</accession>
    <name>A0A1E7N0G9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1981"/>
    <dbReference type="EnsemblBacteria" id="ARF79573">
        <property type="protein sequence ID" value="ARF79573"/>
        <property type="gene ID" value="B6264_12200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34188">
        <property type="protein sequence ID" value="OEV34188"/>
        <property type="gene ID" value="HS99_0037050"/>
    </dbReference>
    <dbReference type="OMA" id="STGAWED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="35887" checksum="E16571A5165E759D" modified="2017-01-18" version="1">MNRRNRLLPATIAFATVTALLVSSCSSSGSEDDQDPADGTPSNSPAATAPSTPGDGSATPGTPSAPGTTSAPGTPGTTTAPNTPGTPGTPGTTTPPGSTAQPPAGARWQPTPGLAWQWQLGGTVDQSVDVPVYDIDGFENDASVVAALHAKGRKVICYINAGSWEDFRPDSTAFAKALQGSDTGWKGEKWFDIRKLDQLKPLMAARFDMCRSKGFDAIEPDTIEAYNQNSGFPLTPDDQLAYNRMLAKLAHDRGLAIGLKNDLDQIPALLPDFDFAVNEECSQFDECDRVAPFVKAGKAVFHVEYKLDTDQFCAKTKALGFSSMQKKLDLNAWRKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M7</accession>
    <name>A0A1E7N0M7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554594.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6074"/>
    <dbReference type="EnsemblBacteria" id="ARF78164">
        <property type="protein sequence ID" value="ARF78164"/>
        <property type="gene ID" value="B6264_03855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34247">
        <property type="protein sequence ID" value="OEV34247"/>
        <property type="gene ID" value="HS99_0036955"/>
    </dbReference>
    <dbReference type="OMA" id="HQSCASA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="15327" checksum="61B48071F52E137C" modified="2017-01-18" version="1">MRIGELAERAGTTTRALRYYEQLGLLPARRAGNGYRAYDEGDLRLLREIRMLQDFGFGLKETRPFVECLRAGHPDGDSCPASLEVYRRKLAELDECIGRLQEVREQVAGQFARAVRARDDLAVAEQPPQCELTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P5</accession>
    <name>A0A1E7N0P5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285666.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6073"/>
    <dbReference type="EnsemblBacteria" id="ARF78163">
        <property type="protein sequence ID" value="ARF78163"/>
        <property type="gene ID" value="B6264_03850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34246">
        <property type="protein sequence ID" value="OEV34246"/>
        <property type="gene ID" value="HS99_0036950"/>
    </dbReference>
    <dbReference type="OMA" id="CRVISPI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="12010" checksum="53EA02F30A1E53C7" modified="2017-01-18" version="1">MVRIAGVPAVTDETFAAEVLAAEGPVLVDFTADWCPPCRMMAPVLADVAREEAHRLRVVSVDVDHNPRTQAAYGVLSMPTLMVFRDGRPVRSVVGARAKARLLRELEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N117</accession>
    <name>A0A1E7N117_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0036255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000216.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3929"/>
    <dbReference type="EnsemblBacteria" id="OEV34375">
        <property type="protein sequence ID" value="OEV34375"/>
        <property type="gene ID" value="HS99_0036255"/>
    </dbReference>
    <dbReference type="OMA" id="AVPMQNT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20890" checksum="FF616163F6FBB042" modified="2017-01-18" version="1">MWHDLLVVQIPIVEKILRTVAVYALILVLFRLAGKRGLAGLNTFDMVVVFLLSNVVQNAIIGNDNSLVGGAIGAVTLVVVNSLVTRWLARDPRAARVLEGEPTTVVRDGKLVPGALRELALRPSELEHAVRLQNGDNLSDVARARLEPDGQLLVTLKAAGQSATKGDVDELRERLAAIEHLLTTLAADRRPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N196</accession>
    <name>A0A1E7N196_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside triphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552294.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1059"/>
    <dbReference type="EnsemblBacteria" id="ARF78947">
        <property type="protein sequence ID" value="ARF78947"/>
        <property type="gene ID" value="B6264_08470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34454">
        <property type="protein sequence ID" value="OEV34454"/>
        <property type="gene ID" value="HS99_0035725"/>
    </dbReference>
    <dbReference type="OMA" id="HWLRTKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="35877" checksum="4E1CCC30F5D32915" modified="2017-01-18" version="1">MPANAPGAKLILLTTTHRVAPGLLAWPAWEALRSAGRVLVADEGHPQVAAVRQAGVTVEVVPAGSAPALARLLTGQPAQAGPTVWLGGPDGDPGLTDALARLAVEHAGEVPEIEVLPGSYDLPGARLLDLASVMDRLRSPGGCPWDAEQTHESLVKYLVEEAYELVEAIEEGDRDTLREELGDVLLQVFFHSRIAEEHPTEPFSVDDVAGDLVDKLVYRHPHVFGDVEAGGAAEVEANWEQLKAAEKTDRESVLDGVPAGLPALAYAAKLVSRVRRAGFTGVPDEPYELPAELTAESAGRLLLAVTQRAHDAGVDVDAALRSAARGYRDAVRAAEGLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B9</accession>
    <name>A0A1E7N1B9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="5" type="ORF">HS99_0035835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554275.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene370"/>
    <dbReference type="EnsemblBacteria" id="ARF78927">
        <property type="protein sequence ID" value="ARF78927"/>
        <property type="gene ID" value="B6264_08360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34474">
        <property type="protein sequence ID" value="OEV34474"/>
        <property type="gene ID" value="HS99_0035835"/>
    </dbReference>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23572" checksum="5F944CC008F1B1A0" modified="2017-01-18" version="1">MLFNRHKTSLVPADQALPGRQAPGFALTEPHTVLGHPLTGPYPEGLEVADFGLGCFWGAERTFWLLPGVWTTLVGYQGGHTPNPTYEEVCSGLTGHTEAVRVVFDPAVISYERLLKTFWEAHDPTQGNRQGNDVGTQYRSALYTHSPAQAAAAGATRDAFQPALTALGYGPITTEIAPAGPFYPAEPYHQQYLSDAKNPNGYCGLGGTGASCPIGVARTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1D2</accession>
    <name>A0A1E7N1D2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557414.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7059"/>
    <dbReference type="EnsemblBacteria" id="OEV34486">
        <property type="protein sequence ID" value="OEV34486"/>
        <property type="gene ID" value="HS99_0035395"/>
    </dbReference>
    <dbReference type="OMA" id="ITFLWEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="131"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="438" mass="47428" checksum="1235685EF08448D1" modified="2017-01-18" version="1">MTDRRPPAFVLTGAFWVVCRNPRYLQELAARGLKILLITPRGWRERALAAQADPTGPAAMIDEIAFVDGELNQDGSFTAGVLARAADWRARYRIVGAYAVGETLVEPTGLLADALGLPGPGLRATRVCRSKPLQRWYLPEFAPPGAVLPAAERAAFEPASVEYPVVLKPAARHSSSGVVTVGDEQVLAARLADYPEHETLLVEQKVVGQEYSVESLVQEGKVVFASVTRKTTTESHAATFVELSHSVPSAPEPVDRALLEANATMLAALDFGSGIAHAEWRVDAAGRPVLMEVAARTPGDGLLALYRLATGEPLEPEIVRLALGEPADYPEPRRWTRQVYLEHREGVLDDVRVDWPGVRPVWLGEAGIWPDPPVGGPDGPGELRAVLVLKERGSRLGPLESSEDRAVCFLIDAPSPEELDALEQRVRAAVAIEVRDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1R6</accession>
    <name>A0A1E7N1R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389671.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000470.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N1R6"/>
    <dbReference type="STRING" id="1894.JOER01000033_gene4271"/>
    <dbReference type="EnsemblBacteria" id="ARF82008">
        <property type="protein sequence ID" value="ARF82008"/>
        <property type="gene ID" value="B6264_26775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34627">
        <property type="protein sequence ID" value="OEV34627"/>
        <property type="gene ID" value="HS99_0009015"/>
    </dbReference>
    <dbReference type="OMA" id="AGDHWFV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17975" checksum="B7DD6BFA9BDAB971" modified="2017-01-18" version="1">MSDSTLSGARVCADRFRSVLSHYPTGVVLVTAPPPAPAQPPPAMIVGTFTSVSLDPRLVGFLPAKSSTSWPRIRAAGRFCVNVLAADQQQVCRGFAARDPARWEVPYRLTPAGCPALVDALAWLDCEPAGEVEAGDHWFVTATVRDLAVQRTGPPLVFLRGDYGRCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U6</accession>
    <name>A0A1E7N1U6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387339.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000831.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4238"/>
    <dbReference type="EnsemblBacteria" id="OEV34657">
        <property type="protein sequence ID" value="OEV34657"/>
        <property type="gene ID" value="HS99_0009180"/>
    </dbReference>
    <dbReference type="OMA" id="PQWSALI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198668" description="Peptidase S53 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="2">
        <location>
            <begin position="78"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="42598" checksum="68CE8E103D51DD8D" modified="2017-01-18" version="1">MRGVRPIRSLLATALALVGLAVVPATAQAHGSPPGHHPPTLERVCPQPSGPLQAACTAVIRTDVPPIASLPPGANPPGLSPFDIRSAYKLFGQHGRGRTVAVTDAYHDPNLESDLAVYRRQFHLPPCTTANGCLRVVNQNGGSTLPTTVDPGWSLEESIDVDAVSAACPDCHILVVETDSAVPGDLFAGVDQAVAQGAKFISNSWDLPEASFEGAFDFHFNHPGVAFTFASGDTGGVPKYPASSPYVTAVGGTTLTRAHNRRGWTESAWEGTGCGCSLFEPKPAFQHDTICPNSRTTVDVSAVATNFPVYDTVPTVFGIGWLTTFGTSISSPLVASMYALAGNPAPGTFPNSYPYARPRDFFDITTGSAGAFSAMPGYDAPTGIGTPDGVDGLRDPRHEWHGATGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2K3</accession>
    <name>A0A1E7N2K3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0034865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737925.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000250_gene1"/>
    <dbReference type="EnsemblBacteria" id="OEV34900">
        <property type="protein sequence ID" value="OEV34900"/>
        <property type="gene ID" value="HS99_0034865"/>
    </dbReference>
    <dbReference type="OMA" id="RYVFGNK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="8">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ETF_alpha" evidence="7">
        <location>
            <begin position="160"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="28282" checksum="3A4F0AB3419AE765" modified="2017-01-18" version="1" fragment="single">LGAGAAAADIAAKAAEFGAAKVYVADGAEFADQLVVPKVDALAQIAKTVSPAAVLVTSSGEGKEVAARVALRIGSGIITDAVDLEAGDGGPVATQSVFAASFQVKSKVTKGAPVITVKPNAVAPEAAPAAGAVENVSVEFTGNAAKVTSRTPRVSTGRPELTEAAIVVSGGRGVGAAEGFGVVEELADALGAAVGASRAAVDAGWYPHSNQVGQTGKQVSPQLYIAAGISGAIQHRAGMQTSKTIVAVNKDAEAPIFELVDYGVVGDLFQVLPQLTTEVKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L5</accession>
    <name>A0A1E7N2L5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554094.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5863"/>
    <dbReference type="EnsemblBacteria" id="ARF77551">
        <property type="protein sequence ID" value="ARF77551"/>
        <property type="gene ID" value="B6264_00165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34910">
        <property type="protein sequence ID" value="OEV34910"/>
        <property type="gene ID" value="HS99_0034930"/>
    </dbReference>
    <dbReference type="OMA" id="RQAHETT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="28090" checksum="2ED23A4220CF8992" modified="2017-01-18" version="1">MEISEHIDALRREGVLLADAAARTDLAAPVPTCPDWRLSDLVRHVGQVHRWAAAYPSQGLDAVLDEAGAQAVIGPDPSDAALLDWFREGHAALVTTLSEAPADLECWSFLPAPSPLAFWARRQAHETAVHRFDADAAAGSPGPAVDPAFALDGIDELLRGFMARGRAKVHCDGPRTVRIRATDGPGSWRLTVSREPLAVTTEESPEPADLTITGPAHELYLLLWNRLTVEQAERQAQTGPVELSGDRGLLDLWRDGAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T1</accession>
    <name>A0A1E7N2T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366321.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000562.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4683"/>
    <dbReference type="EnsemblBacteria" id="OEV35009">
        <property type="protein sequence ID" value="OEV35009"/>
        <property type="gene ID" value="HS99_0034290"/>
    </dbReference>
    <dbReference type="OMA" id="INGTEHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198694" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9561" checksum="A7893BE52AF982A7" modified="2017-01-18" version="1">MRRQIIGAFMLAAAGTFALAAPAGAASGLLVVNGVPRHNPPRGCYPASSPVTIHNHTNTMVLVHAAANCQGPVTAEVEPGQSARTFGASYFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3K7</accession>
    <name>A0A1E7N3K7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282774.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5293"/>
    <dbReference type="EnsemblBacteria" id="ARF80707">
        <property type="protein sequence ID" value="ARF80707"/>
        <property type="gene ID" value="B6264_18940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35281">
        <property type="protein sequence ID" value="OEV35281"/>
        <property type="gene ID" value="HS99_0033000"/>
    </dbReference>
    <dbReference type="OMA" id="AWLASWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14947" checksum="DFE23BF1B131862F" modified="2017-01-18" version="1">MAYTTDETLTVLVYSDDRNTREQVLTALGRRPAEDLPELSYLECATTPAVIKALEKGGIDLCVLDGEAVPAGGLGLGRQLKDEIYGCPPVLVLIGRPQDSWLAAWSRADAAISHPVDPVALAGAVGTLLRARLAKRAPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3M6</accession>
    <name>A0A1E7N3M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282787.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5300"/>
    <dbReference type="EnsemblBacteria" id="ARF80712">
        <property type="protein sequence ID" value="ARF80712"/>
        <property type="gene ID" value="B6264_18975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35286">
        <property type="protein sequence ID" value="OEV35286"/>
        <property type="gene ID" value="HS99_0033035"/>
    </dbReference>
    <dbReference type="OMA" id="AMPINTI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="36691" checksum="E2269D4334933FD1" modified="2017-01-18" version="1">MASHRRPKQPSRARVSVLTAAAATAVALSAQVAAHAAPQPNTSDVKAQIDQLQQEQEQAAEKYNGAKERADQLRKQADQLQDQVARSQDQMSQLQTGLAQVAGEQYRTGGIDPSVQLMLSSDPTGYLDKASSVQQASETQTEALKGLLDQQRRLDQEKAEAAAVLASLDATTKDLNQAKADVNQKLKAAQDLLNSLSAAERAALKAQQQQDDRASRGAARVDLSSLPPASGYAAVAVAKAMSKQGSPYVWGATGPSTFDCSGLMLWSYAQAGVSLPRTSQEQGDVGTRVPSLDQAQPGDLVIYGSDRHHVGMYIGNGMVVHAPHTGDVVKVMKADAMPINTIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3S4</accession>
    <name>A0A1E7N3S4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5271"/>
    <dbReference type="EnsemblBacteria" id="OEV35325">
        <property type="protein sequence ID" value="OEV35325"/>
        <property type="gene ID" value="HS99_0032890"/>
    </dbReference>
    <dbReference type="OMA" id="LMRTLQM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="21394" checksum="06BBC60445B324EE" modified="2017-01-18" version="1">MEKQDETPQARHPQAKKGRPTPKRSEAEANRRTRVTVPKDRKEASRQARDRMRTEREKQRQALIDGDERHLPARDKGPVRKFARDYVDSRWSLAEFFLPAAVVILVLSIIKVPTLQLLSTLLFLLFFVLVILDFVRLGFGLRKQLGERFAGQNTRGVVAYGIMRTLQMRRLRLPKPQVRRGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N498</accession>
    <name>A0A1E7N498_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5499"/>
    <dbReference type="EnsemblBacteria" id="ARF79407">
        <property type="protein sequence ID" value="ARF79407"/>
        <property type="gene ID" value="B6264_11165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35518">
        <property type="protein sequence ID" value="OEV35518"/>
        <property type="gene ID" value="HS99_0031975"/>
    </dbReference>
    <dbReference type="OMA" id="VPDDTHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="76" mass="8371" checksum="704B6A86F63DE5A7" modified="2017-01-18" version="1">MPALTIRDVPDDQIQTLKIRAAQAGKSLQAFMQDLIAREVSKPTMAEMMERLNRETTARVSATDIVAAIDEGRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C1</accession>
    <name>A0A1E7N4C1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5550"/>
    <dbReference type="EnsemblBacteria" id="OEV35541">
        <property type="protein sequence ID" value="OEV35541"/>
        <property type="gene ID" value="HS99_0031720"/>
    </dbReference>
    <dbReference type="OMA" id="GNHLMFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198752" evidence="1">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15027" checksum="A9051827FABAC8B3" modified="2017-01-18" version="1">MAAVLGGGAILAACGTGGQDGTAAADTAPAKLSVADSYIPLPPAGGMGAGYLTVRNDGGPDQLVKVSSPAAGSVTIHRSTASTMEQVSSLDVPAHGALQLARGGTHLMIMDWQKAPALGDELELDLTFAKSGTISVKVPVKELTYRPGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P1</accession>
    <name>A0A1E7N4P1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1611"/>
    <dbReference type="EnsemblBacteria" id="OEV35433">
        <property type="protein sequence ID" value="OEV35433"/>
        <property type="gene ID" value="HS99_0032250"/>
    </dbReference>
    <dbReference type="OMA" id="LVYWSMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198751" evidence="1">
        <location>
            <begin position="32"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="426" mass="44819" checksum="AA30FE9D39090DA2" modified="2017-01-18" version="1">MSARRVVGAATAAALALGASACGGSGDGAKASGGFTYWSMWRADEPQAKVLKAAIDDFTAATGAKVNITWAGRDIAKKIGPAIAANQAPDLWDESDDKVYGTTAAADQALDLSPVLQLQVPGEDFPVSQVLPAKYFDMLPKDPSGSNHYVIPYEIVTNAMFYNAADPAIAAAMPSPPTDWAGLLKVCDALKAAGKACIASEGEDPWSNALYFDYLLNGAGVNVSQLAADKSGATWDAPAVLTAAQQVEQLVKGGHLIEGYDATKYPTQETNWASGKAAFYMDGNYVTAEVAKQVPAGWKMASMLPPTAKTPDANLIGFASPKRAKNAAAAQKFIAFFLQKKHLAGISTTALNLTPRADIPAPAELADVQKALDAPAVRLGFDGVSGSWLPKVLNENYLDLWHGKTTAAQFVAKCKADQVSYWQTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q6</accession>
    <name>A0A1E7N4Q6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551135.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene896"/>
    <dbReference type="EnsemblBacteria" id="ARF80875">
        <property type="protein sequence ID" value="ARF80875"/>
        <property type="gene ID" value="B6264_19920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35677">
        <property type="protein sequence ID" value="OEV35677"/>
        <property type="gene ID" value="HS99_0007150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="24154" checksum="775F1D8D068C268B" modified="2017-01-18" version="1">MRRTSALLSTALLAGAAALAAPATAAQAAPACSAFVAGWSAVGSCSGLDPMQTWSVGATCYYWNSTHTVQFSRPAIGGVAVGDGSLSAACGVGDSVMFPHIIMGATPPAGPTGQITGYVGKCVDVRGANLGNGTPVQIYDCNGTIAQKWRTGVDGTVRALGKCMDVSGGGTANHTMVQLYDCNGTGAQQWQYRADGSLLNPQSGRCLDDLGFSTANGNQLGIWDCNGAANQKWNLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4S6</accession>
    <name>A0A1E7N4S6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80900">
        <property type="protein sequence ID" value="ARF80900"/>
        <property type="gene ID" value="B6264_20060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35698">
        <property type="protein sequence ID" value="OEV35698"/>
        <property type="gene ID" value="HS99_0007285"/>
    </dbReference>
    <dbReference type="OMA" id="NGCSSHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16213" checksum="58809EA7E33AB6A9" modified="2017-01-18" version="1">MGLLLVALLTVLPCTGLAKADASARPGPGPVSAVSVVTAAEATAQTPLAREAARDTARDAARDTARASDGHHRIAEQQDHWILCTADGQPPHNNGCSSHPFCPQDAQLPNPPPHPQPAAWPLVSPAPEALPRVVPAGLLDGPHPAPDLHELQVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z1</accession>
    <name>A0A1E7N4Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551044.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene810"/>
    <dbReference type="EnsemblBacteria" id="ARF80947">
        <property type="protein sequence ID" value="ARF80947"/>
        <property type="gene ID" value="B6264_20365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35742">
        <property type="protein sequence ID" value="OEV35742"/>
        <property type="gene ID" value="HS99_0007590"/>
    </dbReference>
    <dbReference type="OMA" id="GTMEMLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="41505" checksum="8307D851A0930B0E" modified="2017-01-18" version="1">MATLCRPAVAVPEHVITLEETLDLASALHAGHPQLGLALRLIENTGVRTRHLVQPIEQTLTHPGLTVRNQVYEREAKRRVPEVVERALTHAELRARDIDLLIYVSCTGFMMPSMTAWLINTMGFRSDTRQVPIAQLGCAAGGAAVNRAHDFCRAYPGANVLIVACEFCSLCYQPTDLEVGSLLSNGLFGDAVAAVVMRGRGGSGVHIERNGSHLVPDTENWISYGVKDTGFHFQLDKRVPGTMEMLAPALRTLAGQHGWDVSGLGFYIVHAGGPRILDDLCHFLNLSPEKFRYSRATLTERGNIASAVVFDALARLFADGGAPEGTPGLIAGFGPGITAEISLGSWIGAPPEPAHRRLRAISTSDIALVHQGVPRRFPTGTTITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N504</accession>
    <name>A0A1E7N504_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0031730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552786.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000802.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N504"/>
    <dbReference type="STRING" id="1894.JOER01000016_gene5548"/>
    <dbReference type="EnsemblBacteria" id="ARF82752">
        <property type="protein sequence ID" value="ARF82752"/>
        <property type="gene ID" value="B6264_10925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35543">
        <property type="protein sequence ID" value="OEV35543"/>
        <property type="gene ID" value="HS99_0031730"/>
    </dbReference>
    <dbReference type="OMA" id="FVCWQAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="423" mass="43414" checksum="642EC66993A47FC1" modified="2017-01-18" version="1">MRDTEKGPAGFTRRALLGTAGAGLLVGAGAGVAGAVAYDRPDGDTAANGVAAGGGALGTGRVPFRGEHQAGILEPQQAGVRLAAFDLADGAGRDGLRTLLQRWTRAVDRLTAGEPTQEFDNQVALDAGPCSLTVTLGFGAALFDRAGLADRRPAALEPLPAFPGDALDPARGGGDLFVQIGADDALVAVHALRTLQKLATGTAALRWQSAGFARTPGATARPMTGRNLMGQIDGTNNPRPGEDGFAAKVFCTAGGDQPAWLAGGSYLVFRRIRMLLDHWEELPVERQERVIGRRKSDGSPLSAPAGSGEGTAVDLSAQGPDGGPAIPSDAHIRVAAPAGNGGAAMLRRGFSYHDGALPDGSPDAGLLFLAFQADPRKGFTPVQRKLSRGDGLSRFLRHEASGLYAVPPGVPAGGYLGQQLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N529</accession>
    <name>A0A1E7N529_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281519.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene794"/>
    <dbReference type="EnsemblBacteria" id="ARF80962">
        <property type="protein sequence ID" value="ARF80962"/>
        <property type="gene ID" value="B6264_20445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35754">
        <property type="protein sequence ID" value="OEV35754"/>
        <property type="gene ID" value="HS99_0007670"/>
    </dbReference>
    <dbReference type="OMA" id="RSINTDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13947" checksum="812D0567E59B74A5" modified="2017-01-18" version="1">MRHRLLRAALASAAAIALATATAPAVHAMPTAPRCPKGHLCLFDGPHQTGRILLNEDAHVTSEGFSLRELDDIEPPIHPRSAVAPLPNDFGCIIRLNDQPHFAGDEQELAHFGPHELDGRRVGSLTPDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N558</accession>
    <name>A0A1E7N558_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366877.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000155_gene6628"/>
    <dbReference type="EnsemblBacteria" id="ARF81030">
        <property type="protein sequence ID" value="ARF81030"/>
        <property type="gene ID" value="B6264_20860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35820">
        <property type="protein sequence ID" value="OEV35820"/>
        <property type="gene ID" value="HS99_0008085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="16057" checksum="62C800B2CBA4C6FB" modified="2017-01-18" version="1">MVHSAIDADTRSTTLYFQRCTWCNNPTFQRLLCPTCGSTELRLEPSEGTGVVRRCAVEQARTPLVRQKSLIRMAEGFDVWCIVDGMRSTVPVGTRVRLYSSPGSDQPELRLLTVEEPPVEQDPEPRPLPPVKGGFTQHLAAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N582</accession>
    <name>A0A1E7N582_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pup--protein ligase</fullName>
            <ecNumber evidence="1">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pafA</name>
        <name evidence="2" type="ORF">HS99_0008290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286131.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3341"/>
    <dbReference type="EnsemblBacteria" id="ARF81064">
        <property type="protein sequence ID" value="ARF81064"/>
        <property type="gene ID" value="B6264_21070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35852">
        <property type="protein sequence ID" value="OEV35852"/>
        <property type="gene ID" value="HS99_0008290"/>
    </dbReference>
    <dbReference type="OMA" id="CVSQRAE"/>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="51848" checksum="AEAC652C8A3EB646" modified="2017-01-18" version="1">MDRRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDDVVELVTHDKAGERILEGLLVDAERRLHEEGIAGDVYLFKNNTDSAGNSYGCHENYLVARHGEFSRLADVLIPFLVTRQLICGAGKVLQTPRGAVYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSETTTLLKVGATDLVLRLIEAGVVMRDLTLENPIRAIREVSHDLTGTHQVRLANGREASALDIQEEYYTKALEFADRKGINTGTIARVLDLWGRTLEAVRTERLDGVATEIDWIMKYKLIERYRDKHQMTMSNPRVAQIDLAYHDIHRRRGLFYLLQGKGQAERVTTDLKTFEAKSIPPQTTRARLRGDFIRRAQEQRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDERVEKLIAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N589</accession>
    <name>A0A1E7N589_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0008370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7243"/>
    <dbReference type="EnsemblBacteria" id="OEV35866">
        <property type="protein sequence ID" value="OEV35866"/>
        <property type="gene ID" value="HS99_0008370"/>
    </dbReference>
    <dbReference type="OMA" id="IWRYYAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="384" mass="38968" checksum="014E4942BD789C68" modified="2017-01-18" version="1">MREVGKPLAEARGEVARTAAIWRYYAQAPYEPSGAVHETAAGPGLLLTRRRPYGVAGLIAPWNFPLAIPSWKAAPALAVGNTAVLKPAPEATACALRLAELTALASLPEDVFTVLPGGAEEGVALVEAADVVSFTGSTGVGRAVVRAATGRGVPVQAELGGLNAALVLPDADVELAAGHIAAAIAGYAGQKCTATSRVIAVGAAYAPLREALVKALAAVDDSVCGPVVNEAARERMTGAVSSAVEAGASVLVGGGVPERAGWYVEPTLLADVPDQHPLAREEFFGPVAVLHAAADLDEAIALANDTPHSLATSVHTRSLDAALAAADRLDAGMIRVNAPSSGVDFHLPFGGTKGASHGEREQGRAALEFYTVSRTVSVLPGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J7</accession>
    <name>A0A1E7N5J7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0007780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35976">
        <property type="protein sequence ID" value="OEV35976"/>
        <property type="gene ID" value="HS99_0007780"/>
    </dbReference>
    <dbReference type="OMA" id="WHFGQYV"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="184"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="37062" checksum="38B4DAE36100604D" modified="2017-01-18" version="1">MSGTGSTPEAHPEALPVIDLSLADGTPEDRRRLHDELRAAATGVGFFQLVGHGVTQEEKAALTGAMRAFFALPEADRLAVSNLNSPHYRGYTRTGDERTGGSQDWRDQLDIGAELPPHAPGAGEPPYWWLEGPNQWPTALPELRTAALGWIDHLGTVARRLLHELLASIGARPDFYDDAFAGHPHLRLKLVRYPGTAPDGAGQGVGAHKDYGFITLLLQDTVGGLQVERPDGTFLDVPPLDGAFVVNLGELLEVATDGYLKATSHRVVSPAGARERFSVPFFYNPRLDAHIEPLDFPLAHHAPGATEDPANPLFADFGFNEWKGYTRAHPEVTRRHHAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J8</accession>
    <name>A0A1E7N5J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene795"/>
    <dbReference type="EnsemblBacteria" id="OEV35970">
        <property type="protein sequence ID" value="OEV35970"/>
        <property type="gene ID" value="HS99_0007665"/>
    </dbReference>
    <dbReference type="OMA" id="CAVDTGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="49820" checksum="4EF3ABA4D9E5D89A" modified="2017-01-18" version="1">MDTTTSEAACAAGLTPEELSAFSRTLGRLRGLPSHDRTRLHAERQLSSFVTESRKRRRQEAKEALRQADADLLAATATGARHRREDAPLTAVPTGPVGELQVPRRCYVCKQPYRRVDGFYHMLCPDCAADNTARRGLSTDLRGRRALLTGGRVKIGFQLALMLLRDGAELTVTSRFPQDTVRRFRAAEGSDQWWERLTVVGIDLRDPRQVLCLTDQLCADGRPLDILVNNAAQTLRRPPESYALLAAGETTALPAADRRAVTRAPGFRPFTGAAQLPSGAGPLLDLTDEAGLLPDLAPANSWSATLGSLDPAEVLETQLVNALAPALLCDRLLPLLLASPHRARYIVNVTAVEGRFAVRNKTARHPHTNMAKAALNMLTRTSAAELAPRGVHMCAVDTGWITDENPAPRKTRIAARGFRTPLDIVDGAARVYDPIVRGEAGDPVSGVFLKDYRVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y8</accession>
    <name>A0A1E7N5Y8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="15" type="ORF">HS99_0031495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene518"/>
    <dbReference type="EnsemblBacteria" id="OEV36064">
        <property type="protein sequence ID" value="OEV36064"/>
        <property type="gene ID" value="HS99_0031495"/>
    </dbReference>
    <dbReference type="OMA" id="CRTCPLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="14">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV36064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="12437" checksum="479E716E94CCFD04" modified="2017-01-18" version="1">MPSVPPTSQITKADQADPPEVPFMQLNSIEQAEALGLPIPCRAFDPEVFFAETPADVEYAKSLCGTCPVKEACLAGALERREPWGVWGGELFVQGVVVARKRPRGRPRKTEVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N681</accession>
    <name>A0A1E7N681_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829602.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8076"/>
    <dbReference type="EnsemblBacteria" id="ARF79813">
        <property type="protein sequence ID" value="ARF79813"/>
        <property type="gene ID" value="B6264_13675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36200">
        <property type="protein sequence ID" value="OEV36200"/>
        <property type="gene ID" value="HS99_0030620"/>
    </dbReference>
    <dbReference type="OMA" id="NSPNFHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="10956" checksum="B647310E117105E4" modified="2017-01-18" version="1">MIQKSFAAAGLAVAALAGAAAPASAIGNADGGAASIEGNGGTNFTGTVGNNSPNFHFLDNPNVCLPEIHNIAVAVLGVAVPVEVPVANTGGKQYCTVGQGTQSTGDGGVSHLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I0</accession>
    <name>A0A1E7N6I0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0030240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2630"/>
    <dbReference type="EnsemblBacteria" id="OEV36289">
        <property type="protein sequence ID" value="OEV36289"/>
        <property type="gene ID" value="HS99_0030240"/>
    </dbReference>
    <dbReference type="OMA" id="YHGNTNY"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="425" mass="46471" checksum="8FE3EEE7BC4C04A4" modified="2017-01-18" version="1">MVAGTGIVDVAGIGFGPSNLALAAAIAEIAGEAPVSARFFEAQPRFGWHRGMLIEGATMQVSYLKDLVTMRNPTSPYSFLCYLQARGRLADFINTKSPYPLRVEFHDYLEWVAESFADLVSYGARVVSVEPVSAEQGVEFLDVHFVAPDGTRQVQRARNLVIAAGIEPRLPAGLPASPRIWHTAKFLPEVDRIARQDPRSFVVLGSGQSAAEAIEHLHARFPRAQVHSVHARYGFSVADDSPFANQVFNPEAVDRFHTAPDDVRQRLIDYHASTNYSVVDADLLHSLFQQAYLEKVAGNPRLNFHNVSRVSEVTETPDGLRIDVESLSSGTSTVIEAQALVCATGYTRTDPAVFLDGLLPHCPLDDQGRLRLDREHRVVTDESVRCGIYVQGFGEHSHGLSETLLSLSAVRAGEIGDMLVKALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I4</accession>
    <name>A0A1E7N6I4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550863.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2635"/>
    <dbReference type="EnsemblBacteria" id="OEV36285">
        <property type="protein sequence ID" value="OEV36285"/>
        <property type="gene ID" value="HS99_0030215"/>
    </dbReference>
    <dbReference type="OMA" id="SMFANRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="459" mass="50211" checksum="C67C9C2CCB9E6374" modified="2017-01-18" version="1">MPGSVGATDPAERYELSSGQEALWMFEQLVPGTAAYHVPLAFRLRGPLRTDLLDAALTLVVRRQEVLRTAFREDDGEPYQLVLPPAGAEVPLCEVADGAELAEALRREAREPFDLAGGRPFRLRLFRLGPEEHVLSLVMHHIATDGWSLRLLTDELSAGYAALLAGEDPEAALPELPVPYRRYAQWQRECFQGPELEQLLGHWEKELRGIPAVDLAAGRERPRRPSFAADRLVVRLDPELHRALTDLARAARVSLFSWLGAAFSLALTERTGRPDTAFATLFAGRGEPELEPLIGYFVNMVVLRADLADDPAFCEVAARLNAANLRAIDHEVPFGSVVRHLAPARRPGRNPLAQVTLQLRTGGSAPGRPELPGVDCEDVDLYPGQHAFDATVTFIEDGPDFLLSIEYSTEVFDAPWAAGLADQLRALLRAAVDRPGARVSRLPAAVAATPHAPDQGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6K1</accession>
    <name>A0A1E7N6K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4959"/>
    <dbReference type="EnsemblBacteria" id="ARF80027">
        <property type="protein sequence ID" value="ARF80027"/>
        <property type="gene ID" value="B6264_14895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36083">
        <property type="protein sequence ID" value="OEV36083"/>
        <property type="gene ID" value="HS99_0030915"/>
    </dbReference>
    <dbReference type="OMA" id="IAQKEWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="57097" checksum="49C48E888064E9A3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6K4</accession>
    <name>A0A1E7N6K4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0030345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366952.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2608"/>
    <dbReference type="EnsemblBacteria" id="OEV36309">
        <property type="protein sequence ID" value="OEV36309"/>
        <property type="gene ID" value="HS99_0030345"/>
    </dbReference>
    <dbReference type="OMA" id="MIPSEWV"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="960"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1040" mass="111591" checksum="B26DD15BCE4FD041" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L8</accession>
    <name>A0A1E7N6L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4981"/>
    <dbReference type="EnsemblBacteria" id="OEV36103">
        <property type="protein sequence ID" value="OEV36103"/>
        <property type="gene ID" value="HS99_0031025"/>
    </dbReference>
    <dbReference type="OMA" id="ALGAHPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="22193" checksum="4B56F360A87B85B3" modified="2017-01-18" version="1">MNPAPTAHARVILLSGPSGSGKSSLAERSGLPVLQLDDFYKDGDDPTLPRLPDGAVDWDSPLAWHRDQAVAAIRALYEQGRTEVPVYSIPDNGRVSTRPLDLGGATAFIAEGIFAAEIVAECAAEGLLGDALCLRNGALTTAWRRLRRDVREGRKSLPVLLRRGFRLMRAERAIVGRQVELGSYPCAGAEAERRVRAAAGPLELSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6S3</accession>
    <name>A0A1E7N6S3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829724.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000947.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4885"/>
    <dbReference type="EnsemblBacteria" id="ARF83137">
        <property type="protein sequence ID" value="ARF83137"/>
        <property type="gene ID" value="B6264_29040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36406">
        <property type="protein sequence ID" value="OEV36406"/>
        <property type="gene ID" value="HS99_0029620"/>
    </dbReference>
    <dbReference type="OMA" id="THWNVAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="628" mass="65053" checksum="18E574C55933F913" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X5</accession>
    <name>A0A1E7N6X5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene206"/>
    <dbReference type="EnsemblBacteria" id="ARF82243">
        <property type="protein sequence ID" value="ARF82243"/>
        <property type="gene ID" value="B6264_28205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36452">
        <property type="protein sequence ID" value="OEV36452"/>
        <property type="gene ID" value="HS99_0029400"/>
    </dbReference>
    <dbReference type="OMA" id="MTTHEVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32232" checksum="2895FED0C71B5588" modified="2017-01-18" version="1">MIEVNELTKRYGRRTAVDRLTFTVRPGHVTGFLGPNGAGKSTTLRMALGLNDPTSGTVTVDGRAFRGLPRGLREVGALLDAGDVHGGRTGVAHLRVLARSNAIPRGRVEEVLAEVGLTDAAGRRIGGYSLGMKQRLGIAGALLGDPPVLLFDEPLNGLDPEGVLWVRGLFRRLAAEGRTVFVSSHMMAEMEHTADRLVVIGRGRLIADESLTEFAARAGRAAVTVRAAEPERLTAVLRAAGAEIRPGPDGSLDVTGLDAGRIGELALEQRLLLYALTERGASLEEAFMELTADSVEYLAGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Z3</accession>
    <name>A0A1E7N6Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289766.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene177"/>
    <dbReference type="EnsemblBacteria" id="OEV36472">
        <property type="protein sequence ID" value="OEV36472"/>
        <property type="gene ID" value="HS99_0029540"/>
    </dbReference>
    <dbReference type="OMA" id="CVQNCKC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="15494" checksum="890C5CA8B54C87DC" modified="2017-01-18" version="1">MSDTPRIVVGVDGSPASEEALRWAVDYARAVGGTVDAVTAWEYPAFYGWGGTTVPPEAYNPEELAGKTLTESVAKVIGQDAGVPIREGVVPGNAAGALLQAAKGAAVLVVGSRGRGGFSGVLLGSVSRHVTEHAPCPVVVVREGHVEGGAHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N722</accession>
    <name>A0A1E7N722_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289022.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1481"/>
    <dbReference type="EnsemblBacteria" id="ARF79196">
        <property type="protein sequence ID" value="ARF79196"/>
        <property type="gene ID" value="B6264_09930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36502">
        <property type="protein sequence ID" value="OEV36502"/>
        <property type="gene ID" value="HS99_0028650"/>
    </dbReference>
    <dbReference type="OMA" id="VYMGVHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25231" checksum="B54E3545912C0E3C" modified="2017-01-18" version="1">MSTPLADTTNPDLGLLYAVNGLAKSSPQWLDHLVSWIGEYGILIGLAMLGLVGWLQARRRPDAPVAIAGLLWVPLSVAVAELANLPIAAIVDRPRPFVDHPGLLVLVDGKAGTHSFVSDHSTMTMAVAVSLFLVNRKLGWIAGGLALLQGFCRMFMGVHYPTDVIGGYALAVAVVLLLAPIAMAVLVPFCHALGRTAVAPLIRAPERGGTARGSAQRGRRRGRGAVRSEEQPPESDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D0</accession>
    <name>A0A1E7N7D0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289696.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7915"/>
    <dbReference type="EnsemblBacteria" id="ARF79119">
        <property type="protein sequence ID" value="ARF79119"/>
        <property type="gene ID" value="B6264_09485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36579">
        <property type="protein sequence ID" value="OEV36579"/>
        <property type="gene ID" value="HS99_0029100"/>
    </dbReference>
    <dbReference type="OMA" id="PRPLMFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="24768" checksum="CD615733763097CC" modified="2017-01-18" version="1">MSTAVAPTAPARKGKAAALGWLISIAFNVVAPIMIYNQLHDHGYSESTAILASGLGPLVDTVIYLAWHRRIDEFAVVSLVFVALSLVVALVGPTDPKMLLAKDSFVSGLLGVLYLASLAAPKPIMFYFGRKFATDGTPEMISWWNSMWQYEGFRKVQRNLTLVWGVAFVLEAALRIVFVYTLSHGTVVTINNILPYVVIGGLVYWTMTYAKRASARGRAAAEAAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D6</accession>
    <name>A0A1E7N7D6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0029030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552622.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7899"/>
    <dbReference type="EnsemblBacteria" id="ARF82725">
        <property type="protein sequence ID" value="ARF82725"/>
        <property type="gene ID" value="B6264_09555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36606">
        <property type="protein sequence ID" value="OEV36606"/>
        <property type="gene ID" value="HS99_0029030"/>
    </dbReference>
    <dbReference type="OMA" id="PHERMVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="40744" checksum="CC6B36DDE586CE6A" modified="2017-01-18" version="1">MANGSLAPNWLTAYHAVPRHWFVPALVWPGQADGVRQGEAVNRHADPAAWWKAVYSDVPLTTQWDDGDHTGFGRGTMPTSSNSMPTMVFSMLAALDVGDGHRVLEIGTGTGWNAALLSRRVGSDEVFTIEVDEDTAAEARHRLARAGYSPTLVVGEGADGHPDGAPFDRVIATCSVRRIPYAWVAQSRPGAVIVAPWGPEYGGEAVARLVVGDDGTAGGRFVGSSAFMRLRQQRTARPGSLEYLSGPWPADGAKSSTPLSPEALADWLAMFAVGVQVPGAFPLTERYADGTYTLWLHDTAVTSWATADWEPGRTAYEVVQSGPRSLWNEVESAWNWWDDRGRPGFDRFGLTVTPDGHTVWLDGPDNPVPVRTGAVAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I5</accession>
    <name>A0A1E7N7I5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550750.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2529"/>
    <dbReference type="EnsemblBacteria" id="OEV36651">
        <property type="protein sequence ID" value="OEV36651"/>
        <property type="gene ID" value="HS99_0028190"/>
    </dbReference>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="29792" checksum="D9EE5BECD17C8F78" modified="2017-01-18" version="1">MIVVTSVNVNGIRAAAKKGFVEWLAGTEADVICLQEVRSEPGQLPVELRDLDGWHAVWAPSVAKGRAGVAILSRQEPQRTAIGFGSEEFDNSGRYVEIDLPGLTVASLYLPSGEVGTERQDEKERFMVEFLVHLTALRAHATAAGREVVVCGDWNIAHRPEDLKNWKANQKSAGFLPEERAWLSRVYDEAGYVDVVRALHPDRTGPYTWWSYRGRAFDNDSGWRIDMICTTGGIARRATKAYVERPASHAERWSDHAPVTAHFDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J1</accession>
    <name>A0A1E7N7J1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2547"/>
    <dbReference type="EnsemblBacteria" id="OEV36639">
        <property type="protein sequence ID" value="OEV36639"/>
        <property type="gene ID" value="HS99_0028105"/>
    </dbReference>
    <dbReference type="OMA" id="TGRFYDF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="22134" checksum="C37D4E50189E540F" modified="2017-01-18" version="1">MNDVTAVAQLVLHERRARDRGWWDLMREFLAPDAAIRLSWFRGRGAAFIAASQEMAARGDAATHILSPATVDVVGDRAVVEIGAAIHLRGDLHGVEVDLTSHARLLYRAERRGGRWLITSLDPVYEYDSLAPSTPGTAVWLEADVLARARPSYRMLTCLLSAKDYTIADDLYGDDRPEPVRQLYRTLFDWLRADTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V0</accession>
    <name>A0A1E7N7V0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366336.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000853.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4771"/>
    <dbReference type="EnsemblBacteria" id="OEV36749">
        <property type="protein sequence ID" value="OEV36749"/>
        <property type="gene ID" value="HS99_0027415"/>
    </dbReference>
    <dbReference type="OMA" id="HTNSAHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198851" evidence="2">
        <location>
            <begin position="26"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12753" checksum="8DBC4F5EBD7EAB4B" modified="2017-01-18" version="1">MAGALVALLAAVGLSAAASSATAVAATRTAVGSTAVEPGAASADVANVTRGPNVSQVSHVTPVTRVTQVSHVTNVAAKQEKKKSGFFAKLGKFLLVVVILIILVVILLIWAVVHFVRRLFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N826</accession>
    <name>A0A1E7N826_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4834"/>
    <dbReference type="EnsemblBacteria" id="OEV36842">
        <property type="protein sequence ID" value="OEV36842"/>
        <property type="gene ID" value="HS99_0027715"/>
    </dbReference>
    <dbReference type="OMA" id="GPPAWSS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13367" checksum="BC7FD9BC6085C570" modified="2017-01-18" version="1">MRHWHGHGFGPGYGGPGGWGIAVMAIVTLIVLVVLVLLAVALFRYVSRSRQPIAHGPGAVGVGPGAPHGWAHGPTPEQLLAERFARGEIDAEEYRHRRETLRSPDGPSGTSGPGEAGGPDGPSGVGGPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N893</accession>
    <name>A0A1E7N893_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553744.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6850"/>
    <dbReference type="EnsemblBacteria" id="ARF78642">
        <property type="protein sequence ID" value="ARF78642"/>
        <property type="gene ID" value="B6264_06695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36911">
        <property type="protein sequence ID" value="OEV36911"/>
        <property type="gene ID" value="HS99_0026995"/>
    </dbReference>
    <dbReference type="OMA" id="DWHAFVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="6926" checksum="0DA42109186E239C" modified="2017-01-18" version="1">MSTNLTWVKSSYSGTEGGNCIEVASCPSAVHVRDSKDKAGPTLAFSPEAWSAFVSFASEAQAARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F9</accession>
    <name>A0A1E7N8F9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser or Arg-related nuclear matrix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281992.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6470"/>
    <dbReference type="EnsemblBacteria" id="OEV36959">
        <property type="protein sequence ID" value="OEV36959"/>
        <property type="gene ID" value="HS99_0026840"/>
    </dbReference>
    <dbReference type="OMA" id="VGWADCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="28194" checksum="0A3678F0DEDE0BCD" modified="2017-01-18" version="1">MPTTHGGEGPVVHDAYTLPANDNVNPYAFAVELNGSYFLQKGKMVAYYGDITFRGVGAGMVDRMLGQHFNSPLHAADWVVAQGSGKLLLADRAYDLNSYDLDDGNLTVRSGNLLAFDPTLRLKQSIIPGFLTLIGTGRFVAASNGPVHFVEPPIRVDPQALVGWADCPAPCHHYDHDYLHGVVGGLRRLTGIGGASGEEHQFEFIGAGQVLVQSSEQLMAERPVGRVDAEAGVPGGGVPPQPGHGGNHPNQPGLGNLGELGRRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8P6</accession>
    <name>A0A1E7N8P6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37038">
        <property type="protein sequence ID" value="OEV37038"/>
        <property type="gene ID" value="HS99_0004210"/>
    </dbReference>
    <dbReference type="OMA" id="HKHDFFI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="197"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="33210" checksum="01739A2A0BCC5499" modified="2017-01-18" version="1">MVENGQRDVIDIAYENPDQRHTGLEVLTFDALRSRLKRSVTRRPSRLDFHQLLLVRGGEATAMVDFVTHPCTRGTLLHLRPGQVQRLPHDADGRPADLDAVLLLFTADFPPPLPATRSVLDGFGPVAWHLSPEDLAAFDRTTTELAAEYATLRTAHATAELTVALLRQLLGALLIRIARLPAPDPDSDPAPRTDPGAELLLAFRRELERSFTSTRSVEDYAARLGYSPRTLSRACLAATGRTAKQLVDARVALQAQRLLAHTDLPVATIGRTLGFTEPTNFGKFFTRETGQPPGAFRRTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8W5</accession>
    <name>A0A1E7N8W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6641"/>
    <dbReference type="EnsemblBacteria" id="ARF81593">
        <property type="protein sequence ID" value="ARF81593"/>
        <property type="gene ID" value="B6264_24200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37140">
        <property type="protein sequence ID" value="OEV37140"/>
        <property type="gene ID" value="HS99_0004795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="29694" checksum="8DA5E6F0F9A0FFCB" modified="2017-01-18" version="1">MPHPTTRRTARYGWAPDLPDARDFLYSAPRLSLISLPPAADLRGQCPPVYDQGEIGSCTANAIAAAFEFELMRQNLQAFVPSRLFIYYNERVIEGHTSTDSGAQLRDGIKSVANLGVCPEDEWPYDGTPALSDGGPFPPTARAGQKPPANCYTEALKSTVTGYQRVTRDINQFKACLASGFPFVFGFTVYADFESAEVKKTGVAQLPTTDEEVIGGHAVMAVGYDDQTERFIVRNSWGPGWGMDGYFTMPYAYLTEQGLASDFWTIRIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N910</accession>
    <name>A0A1E7N910_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable phosphoketolase</fullName>
            <ecNumber evidence="5">4.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0005015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388137.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6201"/>
    <dbReference type="EnsemblBacteria" id="ARF81558">
        <property type="protein sequence ID" value="ARF81558"/>
        <property type="gene ID" value="B6264_23970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37177">
        <property type="protein sequence ID" value="OEV37177"/>
        <property type="gene ID" value="HS99_0005015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="797" mass="88585" checksum="2C0BA8EE7D867B83" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N961</accession>
    <name>A0A1E7N961_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366269.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37231">
        <property type="protein sequence ID" value="OEV37231"/>
        <property type="gene ID" value="HS99_0005360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198896" evidence="1">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20177" checksum="EAF8DA3826CBCC38" modified="2017-01-18" version="1">MNRTTTRRAATATISLLLASAAALGVSGQAMAAPAPVPAAAAPSHPSSSSAATADTGLRIASLPAQRIAADHRPHEFTVRYAGDTRLAQAQQILVLSPEHGPYLQSEDIRLEWFDDATRHWEPAVLDSQTGTLYTRIPLTGRILTQGSDTAIRYRITLQHDLPTAPRHLTVQPRTILYTAPQTTGNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A1</accession>
    <name>A0A1E7N9A1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0005605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555161.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1294"/>
    <dbReference type="EnsemblBacteria" id="OEV37272">
        <property type="protein sequence ID" value="OEV37272"/>
        <property type="gene ID" value="HS99_0005605"/>
    </dbReference>
    <dbReference type="OMA" id="AGHADVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="221"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="39268" checksum="34D000BC0E6D2BDD" modified="2017-01-18" version="1">MSDGHFAEHEATWRLVKENAGGWDIAGEIPRTVLSGLGAAGVLCAEVRKEHGGLGLGSQESGKLTAHVGSLCSSLRSVMTSQGMAAWTVQRLGTREQRAAFLPQLTGGRLAAVAFSEPDAGSDLGAMTTQLRLDGDTVIVDGSKTWITAAAYADLIVVIGTAGDTAAAVVVPTDAQGVRIEKVPHPMGCRAAGHARVQLEGVRLPAANVLGGTGLSLPFLVTTALAYGRMSVAWGCVGILRGCLGAVTEHARSRRQFGKPIAEHQLVARRIAELYAAERTATAVCQQASECWESGSPDQVIATVLAKHVGATEAVRGAASALQIMASAGASDGHVVARAYRDAKLMEIIEGSSEICQLELARHALATGHGTARQEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9I8</accession>
    <name>A0A1E7N9I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81590">
        <property type="protein sequence ID" value="ARF81590"/>
        <property type="gene ID" value="B6264_24185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37143">
        <property type="protein sequence ID" value="OEV37143"/>
        <property type="gene ID" value="HS99_0004810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="19434" checksum="C15F9191272CD33B" modified="2017-01-18" version="1">MASRYTARGPSSSGAGRPPFHSSASSSSPEPSDTRVREGSAAAGAVTACDSARVRGRLPPGPASFIACGCAAGATEPSGARLRVRSTSVHVPSRRKRTGPAASSVVSVPSGLTQVVDTSLRSDTASTRRPVERAATRAAAMLPVGSTAAAVGGVPGEGLGCGLAANATGAPPASASDSATARDSGPAKVRLGICMRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L0</accession>
    <name>A0A1E7N9L0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81572">
        <property type="protein sequence ID" value="ARF81572"/>
        <property type="gene ID" value="B6264_24070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37163">
        <property type="protein sequence ID" value="OEV37163"/>
        <property type="gene ID" value="HS99_0004920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="18620" checksum="15AE937E62C3A52C" modified="2017-01-18" version="1">MRAERPGSAAGYGHLTTGALGLAAAHERTLDRARVDDEPDLVTQSGSQLPCGDGWFGRTPGVDAAHDLIGQLGRALRAGLAGDHGARPAGVQGGGDLVDRLAAVAEGTGALGDGHLFAAYPPHHLVLDLHHVPRVAERRGEEHLVDRLLPGDPTERASQPGGRVTRSPPADGCRTRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M0</accession>
    <name>A0A1E7N9M0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6207"/>
    <dbReference type="EnsemblBacteria" id="OEV37173">
        <property type="protein sequence ID" value="OEV37173"/>
        <property type="gene ID" value="HS99_0004985"/>
    </dbReference>
    <dbReference type="OMA" id="LQHFRGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="46865" checksum="06280088D3F7B369" modified="2017-01-18" version="1">MRRTAEAEPLPLVVIGGGAAGLSLADCLVGHGHEGHRPRPRLDLTVVEPPEGPLRPPPRTWCFWDDGPGEYERAVTAQWSRLRITGPDGNAVETEPAPLRYRMLRSTAFEELVHDRLGGHPGARIVRATVHRVQTRPDGRPGARVLATDPAGRPLTLDARYVFDSRPPVRPPLARTTLLQHFRGWFVHTDRPRFDPGTADLMDFRLPQPAHGLAFGYVLPLAPDRALVEYTEFSRRPLTTAGYEHALRDYTRRVLGLGALTVEEAEQGVIPMTDGRFPRRAGPAHVRIGTAGGATRPATGYAFAAIQRQSRAIAAALARQPTPGRTAPAPAPHRRRALVMDAVLLRALDTGRIDGPRFFTDLFRRTPAEQVLRFLDGRSTPAEDLRIGLRCPVGPMLRCAAELPLLPRRALPGTGPEPAPDSCEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA04</accession>
    <name>A0A1E7NA04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287149.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7969"/>
    <dbReference type="EnsemblBacteria" id="ARF79075">
        <property type="protein sequence ID" value="ARF79075"/>
        <property type="gene ID" value="B6264_09225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37498">
        <property type="protein sequence ID" value="OEV37498"/>
        <property type="gene ID" value="HS99_0026130"/>
    </dbReference>
    <dbReference type="OMA" id="YGWIDDA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="30852" checksum="D3C12C2C41504DAB" modified="2017-01-18" version="1">MVKTSDGRALAVESLGDPRGRPVFLLHGMPGSRVGPHPRSTVLYRLGVRLISYDRPGYGDSTRLFGRRVSHAAADVRTIADELGLDGFAVLGRSGGGPHALACAAMLPERVSRVAVLVGLAPRNATGLDWYAGMTPSNVRAYREAERGHGRIADAMEFRSRQIKDDPVRLLNGLRTELTGTDREVVADSGLRRMLQSNYREAFRHGADGWIDDVLAFTADWGFDVGSVGVPTWLWHGADDQFSPVDHSRWLADHIPGAELFLEPGAAHFGAFRVMTTALAWAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA33</accession>
    <name>A0A1E7NA33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387822.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1140"/>
    <dbReference type="EnsemblBacteria" id="OEV37551">
        <property type="protein sequence ID" value="OEV37551"/>
        <property type="gene ID" value="HS99_0026455"/>
    </dbReference>
    <dbReference type="OMA" id="QHITSRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="14250" checksum="BED6902948A8B9A3" modified="2017-01-18" version="1">MRVSLSGPPANVFDRMCPSRGVLEHVTSRWGVLVLGALRERGYRFSELRRRVSGVSEKMLAQTLQTLERDGFVLREAHPVIPPRVDYSLTPLGREAAELVAALAHWSEQRVGSVVAAREEYDGRPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA55</accession>
    <name>A0A1E7NA55_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mscL</name>
        <name evidence="10" type="ORF">HS99_0026535</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286478.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000566.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1125"/>
    <dbReference type="EnsemblBacteria" id="ARF79005">
        <property type="protein sequence ID" value="ARF79005"/>
        <property type="gene ID" value="B6264_08820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37566">
        <property type="protein sequence ID" value="OEV37566"/>
        <property type="gene ID" value="HS99_0026535"/>
    </dbReference>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14602" checksum="0B6003E444F70ABC" modified="2017-01-18" version="1">MKGFKEFLLRGNVVELAVAVVIGAAFTNIVNAFVKGVINPIVGAFGTKDLASYSSCLKGPCEVSGTGEVTSGVLILWGSVLSAALQFLITAAVVYFVLIVPMNRMAARRKTVVEEAAEAEAKEVQLLTEIRDALVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA67</accession>
    <name>A0A1E7NA67_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366620.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1148"/>
    <dbReference type="EnsemblBacteria" id="ARF79027">
        <property type="protein sequence ID" value="ARF79027"/>
        <property type="gene ID" value="B6264_08935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37544">
        <property type="protein sequence ID" value="OEV37544"/>
        <property type="gene ID" value="HS99_0026420"/>
    </dbReference>
    <dbReference type="OMA" id="GASYETC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="23398" checksum="C16DBE48C39EC720" modified="2017-01-18" version="1">MKTIRNSRTMALAGLAVVGALTMTACNDDAASSDSASTPPATRAPAAPTGAPTTAAASGSAAAPGGDATGAVPGGSTAGSTGGAPAQAGPTAAPGTTLKIGDAATVPFSSGSTKGTVSLAVTSIDKGDPADLAPLKLGDKVTGMVPYYVRFKVTNTGSTDLSFASLTQVKGTLPDGSEASEVMLIGTFDKCPHPSFPKGFTNGQSITSCVLALAPTATKVAGAEYWGEPYTLGKGVNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ0</accession>
    <name>A0A1E7NAZ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0025125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000254.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5990"/>
    <dbReference type="EnsemblBacteria" id="ARF78004">
        <property type="protein sequence ID" value="ARF78004"/>
        <property type="gene ID" value="B6264_02835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37857">
        <property type="protein sequence ID" value="OEV37857"/>
        <property type="gene ID" value="HS99_0025125"/>
    </dbReference>
    <dbReference type="OMA" id="NWRPTFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33646" checksum="D38FF9C4266C3971" modified="2017-01-18" version="1">MVQRPIAVLGECVADAFADTSRPRPGELALRVMPGGGPANTAVALARLGTTTRFLGRISADPFGDLFRTHLASSGVDLTGVVAAPEPSTMAIATFDAQGQARYSFHAQATADWQWTDAELAAAHSEDAACLHTGSLALVREPGGERIEHLLAQARADATICIDPNVRPLLVDPRIYRTRLAHWCTLTDILRLSSDDLELLMPGVTPEHACDTWHLAGVRLVVITLGARGAVASLDGVRVHVPAPPVEVVDTIGAGDSFTAGLLHRLSLAGRLGGRLDGLTTDEVSDACHYAARVAALTCSAAGPNPPWAHQLDAGPAVATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB42</accession>
    <name>A0A1E7NB42_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366674.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2108"/>
    <dbReference type="EnsemblBacteria" id="ARF79462">
        <property type="protein sequence ID" value="ARF79462"/>
        <property type="gene ID" value="B6264_11530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37912">
        <property type="protein sequence ID" value="OEV37912"/>
        <property type="gene ID" value="HS99_0023860"/>
    </dbReference>
    <dbReference type="OMA" id="VYVVHEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="704" mass="73453" checksum="DC473027EB859F35" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB90</accession>
    <name>A0A1E7NB90_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">HS99_0024165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278336.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000638.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2048"/>
    <dbReference type="EnsemblBacteria" id="ARF79514">
        <property type="protein sequence ID" value="ARF79514"/>
        <property type="gene ID" value="B6264_11840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37960">
        <property type="protein sequence ID" value="OEV37960"/>
        <property type="gene ID" value="HS99_0024165"/>
    </dbReference>
    <dbReference type="OMA" id="IENYRFE"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="9263" checksum="95B918AAF1E42EFC" modified="2017-01-18" version="1">MARVVVDVMLKPEILDPQGQAVQRALPRLGFTGIADVRQGKRFELELEGPVDDAALARIREAAETFLANTVIEDFTVRVEEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBI0</accession>
    <name>A0A1E7NBI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3057"/>
    <dbReference type="EnsemblBacteria" id="OEV38045">
        <property type="protein sequence ID" value="OEV38045"/>
        <property type="gene ID" value="HS99_0022835"/>
    </dbReference>
    <dbReference type="OMA" id="FAMAHPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="533" mass="53319" checksum="E9C13FE0B6CF85FF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK4</accession>
    <name>A0A1E7NBK4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0022790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551649.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8147"/>
    <dbReference type="EnsemblBacteria" id="ARF79752">
        <property type="protein sequence ID" value="ARF79752"/>
        <property type="gene ID" value="B6264_13315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38038">
        <property type="protein sequence ID" value="OEV38038"/>
        <property type="gene ID" value="HS99_0022790"/>
    </dbReference>
    <dbReference type="OMA" id="FITVMCC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="42652" checksum="06E842917B55A073" modified="2017-01-18" version="1">MTLRRQIATAVAAISVLVAVAVGLLVHQAMIRQHVDQARSSALTALNSALTDYARGLTPNPVAALDDPALPTRLHDLAAGGREGTVLATDQQGESMWAAAPVRGGVLSARVDFTQDRRAIADLDRIILLTVVAAVFTTVLAGVLVADRISRRLRTAATAARGIAAGGTDTRIGELVDGKDEVADLAAAVDLMSRTLHRRLEDEQRFTADVAHELRTPLTGLVTAAELLPPGRPTQLVQNRVQALRALVEDLLEVSRLDADVESPDLSAVPLERAVRRTVTLTGLDVRIGITSDQEVRTDLRRLDRILGNLLLNAHRHGASPVELHVDGRRITVRDHGPGYPDDLLDHGPQRFRTNAPERGHGHGLGLTIATGHTRVIGATLTFANHPAGGALATLTLPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCK8</accession>
    <name>A0A1E7NCK8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287724.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene306"/>
    <dbReference type="EnsemblBacteria" id="ARF82172">
        <property type="protein sequence ID" value="ARF82172"/>
        <property type="gene ID" value="B6264_27800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38436">
        <property type="protein sequence ID" value="OEV38436"/>
        <property type="gene ID" value="HS99_0021255"/>
    </dbReference>
    <dbReference type="OMA" id="DGCFADC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="34522" checksum="1D8EC9E50144E459" modified="2017-01-18" version="1">MELEFRHLRIICSIADCGSLTRAAASLRLTQPGVSAQLARIERALGGELFSRAQSGVIPTAFGEEVLSRARAVLPTVDELLEVATLAPQAGWSQHRFRLGSVNAPLLGGLITAIRSHHPEAEISTRGQGCPVPLVEAVAGGRLEAAVVGDSPGYELALPAGVAGEPIATEPLFVALPAAHPLAALEEVALEDLEGEDWAAPRPDNDRIREYWSRTLLVLGRRLRVVHEVEGRLVLDLVRSGHAVSFCQATFEEVPGLAVRPIVGNPLWYRHVLAWHEEGPLASLRPSLVQTVTEAYWTAAARSAVYRSWLERQGATAPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCT4</accession>
    <name>A0A1E7NCT4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288352.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3105"/>
    <dbReference type="EnsemblBacteria" id="ARF82094">
        <property type="protein sequence ID" value="ARF82094"/>
        <property type="gene ID" value="B6264_27325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38510">
        <property type="protein sequence ID" value="OEV38510"/>
        <property type="gene ID" value="HS99_0021720"/>
    </dbReference>
    <dbReference type="OMA" id="CQHQPSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046041">
        <property type="entry name" value="DUF5999"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19462">
        <property type="entry name" value="DUF5999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="63" mass="6834" checksum="90798448D062C2CC" modified="2017-01-18" version="1">MCQHRPECPTAESEDREAAVPVACHPEQGWSLLCNGVVLFEDTGELLPDGRVIAPRRPVAHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU0</accession>
    <name>A0A1E7NCU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385492.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3097"/>
    <dbReference type="EnsemblBacteria" id="OEV38502">
        <property type="protein sequence ID" value="OEV38502"/>
        <property type="gene ID" value="HS99_0021680"/>
    </dbReference>
    <dbReference type="OMA" id="VQFTCRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="25544" checksum="FE8FAC9BE12B671C" modified="2017-01-18" version="1">MLIRSWDRGDEDEWRAWLAEGRDFGLLAANGGPDEGPVLVPTHFLLDAGRGEILLHLATPNPLLAAVRADPNVTLAVTDGYAFAPGHWRGEPGTPTSYYASVHFHCTAEVVESAEGKAEILNRQLAHFQPETPDVRVVPGANEFGRLLSGLRGLRLTVREVRAKFKYDDKKPAEAQYAIADRLAERAEGPPGRRDQDAAARTQLLRRHQRRIARAGGAPGAAGARRTSRPHAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCX5</accession>
    <name>A0A1E7NCX5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554513.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene310"/>
    <dbReference type="EnsemblBacteria" id="ARF83111">
        <property type="protein sequence ID" value="ARF83111"/>
        <property type="gene ID" value="B6264_27785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38531">
        <property type="protein sequence ID" value="OEV38531"/>
        <property type="gene ID" value="HS99_0021270"/>
    </dbReference>
    <dbReference type="OMA" id="TNEYEHN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="46159" checksum="37C6E867D0656346" modified="2017-01-18" version="1">MPGLAVTDHVFTVPLDHAEPGQGTIEVFAREVVDPARAHDPLPWLLYLQGGPGGKSPRPMNATAGWLGHALRTHRVLLLDQRGTGRSTPITARAAERFGSGSGLAHHLARFRADSIVADAELIRRQLCGEGERWETLGQSYGGFVTLSYLSFAPEGLRACYVTGGLPGLDAAAHDVYAATYPRVRDKVNTYYARYPQDRPLVRRIADRLAQRAAQLPDGDWLTVRRLRTLGLVLGMGDGFERLHWLLDQALESDGELAATFLHQVANLTGFTDNPLFAVLQETIYGHPGAATGWAAARAMADRPEFAEDADPLLFTGEMFYPWMFAEIAGLRPFAEAVHLLAERTDWTALYDPVRLAANRVPVAAAVYHDDMYVDAGLSLRTARAVGSLRTWVTNEWEHDGVTASGDRVLARLMDLAADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND77</accession>
    <name>A0A1E7ND77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551421.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000424.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene580"/>
    <dbReference type="EnsemblBacteria" id="ARF77669">
        <property type="protein sequence ID" value="ARF77669"/>
        <property type="gene ID" value="B6264_00905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38637">
        <property type="protein sequence ID" value="OEV38637"/>
        <property type="gene ID" value="HS99_0020490"/>
    </dbReference>
    <dbReference type="OMA" id="RGLAWDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="28849" checksum="226FD5959A9B6CA8" modified="2017-01-18" version="1">MAGGVDLVVIGADGGPDRAFGGSAHAPAGARLLAEVLPGMCFDTGAAGCRVSAVAPDADANAMLTAVRAAAQHPGRWLVVCLVGQLVADPRGRRLALVTGGSTPDNAYRRGLAWDWVVSAMVHGDQEEALLLVDAVADRDAWTALERTGEDTAGELLSYSRVPLWGRIGRYAPGRRGRGAVLPGDEGSFSRALTTVLRQGVPGAPAAVAPSDLQPAVAGLLDGGDPPGSSGAPGARLLVPPQGGRLLMRNRAAVRGALAGLSLSEELLAVLWRESAPTEPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD4</accession>
    <name>A0A1E7NDD4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cation-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000565.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1819"/>
    <dbReference type="EnsemblBacteria" id="ARF77731">
        <property type="protein sequence ID" value="ARF77731"/>
        <property type="gene ID" value="B6264_01250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38691">
        <property type="protein sequence ID" value="OEV38691"/>
        <property type="gene ID" value="HS99_0020835"/>
    </dbReference>
    <dbReference type="OMA" id="NHHTGED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="32058" checksum="F71D3742F44E06D2" modified="2017-01-18" version="1">MPMSFNLNIIEEFRANGGRVGGPFEGGDLLLLTTTGARSGRPHTVPLGFVRSEGLLLVVASAAGAPEHPQWYRNLLAHPVVRVELGTETFDAIAVPAEGDRRKRLFETVVRTAPGYGDYQAHTERELPVVVLERPEAPPGLPSEARSLADKLLEAHTWLRAQLRHVRAEAQSHSPGRPAGLGLQLRQHCLAFCAGLTHHHTGEDSAIFPALARSHPELAGVLEQLGEQHRAIGRIKDELVALLAEIGISEPDRLRSELDRMSAELETHLDHEEAELLPALAGIPFPPVRPGPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD8</accession>
    <name>A0A1E7NDD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0019885</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281347.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene700"/>
    <dbReference type="EnsemblBacteria" id="ARF82524">
        <property type="protein sequence ID" value="ARF82524"/>
        <property type="gene ID" value="B6264_00300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38697">
        <property type="protein sequence ID" value="OEV38697"/>
        <property type="gene ID" value="HS99_0019885"/>
    </dbReference>
    <dbReference type="OMA" id="EMFAQGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="31904" checksum="DF78EBA17BD51C52" modified="2017-01-18" version="1">MEAFATRAEQDGYRPSERRLAHEAYRRSRARRSALIATASTVLTAVALYLLVVNSPGWEVTRRTFFNLDYARQALPEVLRGLRLNLELMLGCGVLILVFGLLLAVLRTLRGPVFLPVRLLATAYVDFFLGLPMIICLLVMITGVPALRLTGVTTDPLLLGGAALVLTYSAYVSEVFRSGIESVHPSQRAAARSLGLTNAQAMRYVVLPQAVRRVVPPLINNLVSLQKDTGLVSIGGAIDAVYAAKIIAAHSFNFTPYLLAGLVFIVLTIPLTRFADWLTGRMNRRQLQGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDM5</accession>
    <name>A0A1E7NDM5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="10" type="ORF">HS99_0019215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553697.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000241.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7395"/>
    <dbReference type="EnsemblBacteria" id="ARF81209">
        <property type="protein sequence ID" value="ARF81209"/>
        <property type="gene ID" value="B6264_21950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38801">
        <property type="protein sequence ID" value="OEV38801"/>
        <property type="gene ID" value="HS99_0019215"/>
    </dbReference>
    <dbReference type="OMA" id="CTVEAAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="694" mass="73464" checksum="94B1A03ADF5D48FE" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE20</accession>
    <name>A0A1E7NE20_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol mannoside acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0018905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737789.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7332"/>
    <dbReference type="EnsemblBacteria" id="ARF82986">
        <property type="protein sequence ID" value="ARF82986"/>
        <property type="gene ID" value="B6264_21635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38914">
        <property type="protein sequence ID" value="OEV38914"/>
        <property type="gene ID" value="HS99_0018905"/>
    </dbReference>
    <dbReference type="OMA" id="GMRSYMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="35321" checksum="6B5AAAF30CD8D945" modified="2017-01-18" version="1">MVYWAYALGWAVLKHLPEPVARWLFDRLADYAWRRRGPRVLQLEANLRRVRPGLHEAALRRLSRAGMRSYLRYWMESFRLPVWSRERVLRDVQVDGLERLREALESGRGAVVALPHMGNWDLAGTWIAQLGHPFTTVAERLKPERLFDRFVAFREGQGMEVLALTGGGVNVIGTLARRLREGKLVCLVGDRDLSEAGIEVSFFGEPTRMPAGPAALCQRTGAALLPATLWYDGPVLRGTIHPEVPVPEEGDRKARTLAMTQAMADVWQRGIGEHPQDWHMLQKFWLADLPAREPAAGGGSAGARPESAAEPAAGASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB5</accession>
    <name>A0A1E7NEB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557492.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1004"/>
    <dbReference type="EnsemblBacteria" id="ARF83289">
        <property type="protein sequence ID" value="ARF83289"/>
        <property type="gene ID" value="B6264_30620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39056">
        <property type="protein sequence ID" value="OEV39056"/>
        <property type="gene ID" value="HS99_0018335"/>
    </dbReference>
    <dbReference type="OMA" id="CAWITTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="33363" checksum="4F4E1D63D51E683D" modified="2017-01-18" version="1">MGPLGRTWRLPFPLDLAHVIGPLHRGARDPVSAWSPGELWRTFRTPAGTGTLRITARPATGEIHATAWGEAADWLLERLPTLLGATDTPEQLVLPPGPLREAQRRNPGLRLCATGLVLDSLIPAIMEQKVTVLEARRGMRYLVRRHGTPAPGPRPDLRVMPSARQWAAIPSWEWHKAGVDPKRAATILRAVRLAPRLEEASTMAGKQAFERLMTVPGIGIWTAAETLQRSNGDPDAVSVGDYHLANHIGHFFTGRARSTDEQMLELLAPYAGQRHRVCKLAFLAGASAPRFGPRLSPNDHRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB9</accession>
    <name>A0A1E7NEB9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6288"/>
    <dbReference type="EnsemblBacteria" id="OEV38833">
        <property type="protein sequence ID" value="OEV38833"/>
        <property type="gene ID" value="HS99_0019400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="2">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="19801" checksum="F717DBC2019B233C" modified="2017-01-18" version="1">MLRAARAGARENAATRVVSASADPLECGLRHAVVRQLFERLLADGADSPYGGRTPGSARRPAPWAPQPSGPSDPMAGQDAAALRDLYQLATQLTAQGSLLVAVDDLQWSDTTSLRWLRHLLHRADDLPLADIATLGPEDARSNSAGIAAAVPLFQHRLTLGGLSDEAVGSLAEEVLGEVGADQRGVVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF9</accession>
    <name>A0A1E7NEF9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052743476.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000345.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83287">
        <property type="protein sequence ID" value="ARF83287"/>
        <property type="gene ID" value="B6264_30605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39054">
        <property type="protein sequence ID" value="OEV39054"/>
        <property type="gene ID" value="HS99_0018325"/>
    </dbReference>
    <dbReference type="OMA" id="WIVNRLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36213" checksum="8F58DE4B16A61065" modified="2017-01-18" version="1">MASKPPTDFDATADALYVLAPTAFTAARNERADEVKKSDPQLAKAIRALHRPTVAAWAANLLAHRHHDLVRQLMDLGQALREAQEHLAGEQLRGLADQRRLLIRALTEQARRDAAAAGHPLASDAVADLDRTLSAALADPDAARALAEGRLTAALEPPLWPGAAPSRTEAGQPNLSTDVGASPDTGTPPARRRPAAERRSHRASATDAPPGDRQDAAAQARAEREWERKRDKARIAVTAAETAEREAADRAAEAERELRSARASRQRAQDEADRAEAALVQARERDDRARDALARADALVRDTETASDSARGRVARAREAARETAERHRRLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEJ8</accession>
    <name>A0A1E7NEJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386069.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4109"/>
    <dbReference type="EnsemblBacteria" id="ARF83346">
        <property type="protein sequence ID" value="ARF83346"/>
        <property type="gene ID" value="B6264_30985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39117">
        <property type="protein sequence ID" value="OEV39117"/>
        <property type="gene ID" value="HS99_0018710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16609" checksum="593D72DD29C3AD5F" modified="2017-01-18" version="1">MIKRLPVLAAAVGLLLAPLAGTASAETTTPAKPAVGSAVTSGVWNTATYNPDGNTNTVEINQYVGSDNHHYVTGWLYAGSSNVAFYYDQSFDGGRTWNSFLDRRYVGPGGWYTLPTKYDDGGVWYRACSAAEWAGSPYANPQWGYNIACTNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEN4</accession>
    <name>A0A1E7NEN4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285076.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3465"/>
    <dbReference type="EnsemblBacteria" id="OEV39159">
        <property type="protein sequence ID" value="OEV39159"/>
        <property type="gene ID" value="HS99_0000025"/>
    </dbReference>
    <dbReference type="OMA" id="GKQPELC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="32716" checksum="007B6F4B5EFC9FA6" modified="2017-01-18" version="1">MQLQQLRYFLAVAETRHFTRAAETEHVAQPSLSQQIRSLERELGAELFHRTRGNIALTDAGDALLPLARRILADTESARLAVQETVQLRRGRVRLGAPPSLCTSLVPDVLRVFRDHYPGVALGVREGGSRDLVRWLAAGELDLALVITPPSGEAAPALAVTELLHEELVLVSAAGPARRPVRVAELRGRPLVMFREGYDVREAALAACRAAGFEPEFAVEGGEMDAVLGFVRAGLGPAVVPGMVAARSGLSVTPFAGPGLGRTIAVAHGHEVPLTRAAEALHDTLLAHLRDAAREGELPPGTRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEP5</accession>
    <name>A0A1E7NEP5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1046"/>
    <dbReference type="EnsemblBacteria" id="OEV39142">
        <property type="protein sequence ID" value="OEV39142"/>
        <property type="gene ID" value="HS99_0018125"/>
    </dbReference>
    <dbReference type="OMA" id="HGRRNTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="66"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="20963" checksum="7CE501904CEA4263" modified="2017-01-18" version="1">MGPEDTDAAQTLHRDLLALLPAARVLLAERDDLARRLEVARRDPLTGLPARAAFTAAAEQLLATANAPAVLMVDLVDFKAVNDTHGHEAGDAVLAVTGRRLAGWAGPGAVVGRLGGDEFAAVLDTDPAGLPGRIAALRGLLEQPADHHGRQLAVGSSIGAATLTDHPTRDLSVLLHAADLAMYADKGRGRRGRRRHSPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE6</accession>
    <name>A0A1E7NFE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387080.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7541"/>
    <dbReference type="EnsemblBacteria" id="OEV39430">
        <property type="protein sequence ID" value="OEV39430"/>
        <property type="gene ID" value="HS99_0001645"/>
    </dbReference>
    <dbReference type="OMA" id="DMEGFDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18008" checksum="F8FC7623729C8EAC" modified="2017-01-18" version="1">MTGRVVVIGMGNPFRRDDGVGPAVIEAVRTQVPADTVLTVSDGEPVRILDLWHRHDQVVVVEAVHAHPGQPGRLLTLRADQAERAAVGSASTHALGLGETFALAAALDRMPRALVVHAVEGADFTLGVGLSPAVRTALPELTRRVADSIRKAHRTLGRAGGDTADGGPHKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG1</accession>
    <name>A0A1E7NFG1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737761.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39446">
        <property type="protein sequence ID" value="OEV39446"/>
        <property type="gene ID" value="HS99_0001730"/>
    </dbReference>
    <dbReference type="OMA" id="DRCRMVL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="175"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="41345" checksum="F245C63A4552078B" modified="2017-01-18" version="1">MARTGRPKVELVLSEDERAALEGWVRRRSTPQAWALRCRIILECASGASNKDVAERLGSTPHAVGRWRARFVEHRIAGLGDMPRPGGPRTVTDEQVAELVAKTLERTPKDATHWSTRSMARETGLSQSTVSRVWRAFGLQPHRAETFKLSTDPYFVDKVHDVVGLYLDPPERALVFCVDEKSQIQALDRSQPVLPMMPGVPQRMTADYVRHGTTTLFAALEVATGKVIGSLHRRHRAEEFKKFLLRLDKEVPEGLDVHLVLDNYATHKTPAIKTWLLSHPRFHLHFTPTGSSWLNLVERWFAELTNKQIRRGVHKSVQALEADIRDWIATWNTDPKPYVWTKTADEILNRLAGYLKRIPDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVF0</accession>
    <name>A0A1E7MVF0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7005"/>
    <dbReference type="EnsemblBacteria" id="OEV32406">
        <property type="protein sequence ID" value="OEV32406"/>
        <property type="gene ID" value="HS99_0017080"/>
    </dbReference>
    <dbReference type="OMA" id="GFYRHAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198482" evidence="1">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="447" mass="47096" checksum="B36524DB721C707D" modified="2017-01-18" version="1">MHTRTTSTVSRAASALLTTALAATVLGAAPAWSAPADGRGAPAADGPRRQVEAFAEDGGISRATAPAASPYLAAPPAGLAAPTGDGDGEVTALVRNGDPATKLDVVVVGDGYSAQEQEKFRTDAAEKWREITAVEPYATYQRLFNVWTVNAVSPESGVTGDPDQATVRHTALGSYFWCDGVERLLCVDEKAVERYAAKAPQADLVIVVANSAKYGGAGYNDVKSPVGYEGIATVAGGNAKSGQIAVHETGHSLGKLADEYAYDGQGTYQGDEPPEANLSTLTADRMSDQGTKWARWLGQSSPDGGTVGTYQGGGYYPTGLYRPTENSIMRSLGREFNLPGREAMIAGFYRHATPLTSPTPVGSWLTAADRLTVDLPVPGTVLRWYLDGREQPRLRGRTALDLDALHLTGPRSRPHLLSAVATDPTPAVADPALRTELTGSLSWLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU5</accession>
    <name>A0A1E7MVU5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289575.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000655.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32383">
        <property type="protein sequence ID" value="OEV32383"/>
        <property type="gene ID" value="HS99_0016950"/>
    </dbReference>
    <dbReference type="OMA" id="TVWTTYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="143"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27047" checksum="1AD6C7ACFCE57AA4" modified="2017-01-18" version="1">MPEATTPYVTGTPCWVDLMAQDQQAALDFYRDLFGWQGQTGPDEFGGYAVCRLNGKPAAGIGPAMAPEGVPEPPTVWTSYLATTDAQATQDAIVAAGGTLLVPVMDVGNLGRMLVAADPQGAVFGVWQALDFPGAGVVNEPGALIWNELHTDDIGGAGAFYGEAFGIEVVPVEGNDQYWELKVGGRPVGGASLLDNDPPGTPAHWLCYFAVDDVDSAADTVVKRNGTLLAPPFDMVAGRMAVVADPQDAPFAIIKPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD1</accession>
    <name>A0A1E7MWD1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285553.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000714.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7817"/>
    <dbReference type="EnsemblBacteria" id="ARF78209">
        <property type="protein sequence ID" value="ARF78209"/>
        <property type="gene ID" value="B6264_04125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32747">
        <property type="protein sequence ID" value="OEV32747"/>
        <property type="gene ID" value="HS99_0015955"/>
    </dbReference>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="36914" checksum="E0C31523163B8F67" modified="2017-01-18" version="1">MTAHEPDLRHHGDAEVRAGGRGLVDLAVNVRTGTPPTWLRERLAATLGDLAAYPDQGAARAAVAARHGRPVEEVLLTSGAAEAFVLLARVLTARHIVVVHPQFTEPEAALRDAGHRVHRVLLSPEDGFRLGAVPEEADLVVLGNPTNPTSVLHPAEAVAALARPGRTLVVDEAFMDTVPGERESLAPLRDLPGRVVVLRSLTKTWGLAGLRIGYVLGPAPLIAALGAAQPLWPVSTPALVAAEVCSGPPALAEAEQAAAELALRRAYLVKCLAAFPALRVYGEPAASFVLVRLPGAAAVRERLREHGFAVRRGDTFPGLGEDWLRIAVRDEETTDRFLNALEAVLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ4</accession>
    <name>A0A1E7MWJ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mechanosensitive ion channel protein MscS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0015300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3860"/>
    <dbReference type="EnsemblBacteria" id="OEV32789">
        <property type="protein sequence ID" value="OEV32789"/>
        <property type="gene ID" value="HS99_0015300"/>
    </dbReference>
    <dbReference type="OMA" id="MILEDQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="40136" checksum="6A2A258FBBFA89E0" modified="2017-01-18" version="1">MDASPALSTPTPVPSPTASPTAPELPQLRIPTSAQEVTDTTKQAASWFDTHWQSWLAAGLQIVLIIVLALVLRVVVSKLITQLITRMARGHDHSEESRLGGLLANHGVVNPERRQQRSEAIGSVLRSVASFTILGTAALMVLSALGMNLAPLLASAGVAGVAIGFGARNLVTDFLSGVFMIMEDQYGVGDEIDTGVATGTVLEVGLRVTKLRGANGEIWYIRNGEVKRIANMSQGWATATVDVQVGYKEDLQRVEDLIQETAEGLAKEAPYDELVWAPVSVLGVESVAADSVMVRVEARTAPGKAAVVSRALRQRLKTAFDQAGIKVKEEATAVATGVSITAAEPAPPSALSDPTSPRYRASEPIPLPKAPTDDPTLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ7</accession>
    <name>A0A1E7MWJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385744.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3832"/>
    <dbReference type="EnsemblBacteria" id="ARF78347">
        <property type="protein sequence ID" value="ARF78347"/>
        <property type="gene ID" value="B6264_04920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32613">
        <property type="protein sequence ID" value="OEV32613"/>
        <property type="gene ID" value="HS99_0015160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="37702" checksum="D8A1FD92B19481B0" modified="2017-01-18" version="1">MTQPNTAADPSAPFSGGRVTTAPVDPEPFLLRIEAAEPGVRLDRWIGANRARLVDELHRHGALLFRGFAVDSPAEFGSAARAYSPDLLDYLERAAPRTEIADKVFTSTELAADRWIDFHHEMSYSHNWPSILYFYGDRPSAQGGATPVASERAVFPKIPQEIRERFQRHGVAYVRNYSPGLDIPWQDVFQTTDRAEVEAYCRASDTEFTWTGDDGLRTRSVRQAVARHPHTGETVWFNHAHMWHVSTLDGDVAEYLLDEYGPEGVPRNAFYGDGTPIEDEAVALIGKLYQEAAVSVPWQRGDVLVVDNFLATHAREPFSGDRRILVAMSDLYVSQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ8</accession>
    <name>A0A1E7MWZ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386890.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000556.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5748"/>
    <dbReference type="EnsemblBacteria" id="ARF81375">
        <property type="protein sequence ID" value="ARF81375"/>
        <property type="gene ID" value="B6264_22890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32962">
        <property type="protein sequence ID" value="OEV32962"/>
        <property type="gene ID" value="HS99_0013860"/>
    </dbReference>
    <dbReference type="OMA" id="HWVDIAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="37775" checksum="A8E92F72C6A87472" modified="2017-01-18" version="1">MPPEGAHRPRRGATTIEDVARAAGVSRQTVSNALNAPHRVRPETLERVTAMIRELGYQPDQSARSLRSGARRTIGYLAPADDPHDPNPLMAGFLEALVDAAGEQGWRVLLFRRARGAADPTAAIDELVAARQVDGLVLADVLAEDARVEHVARLGVPFVTFGRTGPAQPQHWVDIANDAATAAVVRHLAALGHRRIGYLGGSEDLPWMAARRAGFLAESRRLGLAAVTAPGPEAAGVRELLRGPEPPTAVAAGSDLLALDVYEAVRAEGLAVGPRGIAVTGFHDTPLCRHLHPALTSVRLPLGAIAAALVERLLDQVRGAGPPPAGVELAAELVVRGSTAGPAEPRALTAVPAEGARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX72</accession>
    <name>A0A1E7MX72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000084">
        <property type="protein sequence ID" value="OEV32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278975.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2556"/>
    <dbReference type="EnsemblBacteria" id="OEV32833">
        <property type="protein sequence ID" value="OEV32833"/>
        <property type="gene ID" value="HS99_0039945"/>
    </dbReference>
    <dbReference type="OMA" id="PLEVERW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="23001" checksum="5979A06223560397" modified="2017-01-18" version="1">MTAPAAAWVDDPFAEAVRAGRGPLWLRQEDGARIPLDVERWCAPAAASDHSLLRRCLRLNAPVVDLGCGPGRLVAALLALGVPALGVDITGAAVARTRHLGGPALCRSVFDRLPAEGRWGAALLADGNLGIGGDPDALLRRGAELIAPNGLLLVEVEPEEVDERAVVRVEGPDGRLGPPFPWARLGPAATLRRARTAGLVEAERWTSHGRPFLALRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA4</accession>
    <name>A0A1E7MXA4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552440.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5652"/>
    <dbReference type="EnsemblBacteria" id="ARF81458">
        <property type="protein sequence ID" value="ARF81458"/>
        <property type="gene ID" value="B6264_23370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33044">
        <property type="protein sequence ID" value="OEV33044"/>
        <property type="gene ID" value="HS99_0014340"/>
    </dbReference>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="535" mass="55328" checksum="BCE3B3B56F860E9E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM2</accession>
    <name>A0A1E7MXM2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279901.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81399">
        <property type="protein sequence ID" value="ARF81399"/>
        <property type="gene ID" value="B6264_23020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32983">
        <property type="protein sequence ID" value="OEV32983"/>
        <property type="gene ID" value="HS99_0013990"/>
    </dbReference>
    <dbReference type="OMA" id="CEYMSSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6426" checksum="DE2F24275E7C1E36" modified="2017-01-18" version="1">MQPTAEQVRALKDEDFRLTLGQGHQVHPAGELADELYVTAAVLNSTCDGWSSCGRVCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ6</accession>
    <name>A0A1E7MXQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7112"/>
    <dbReference type="EnsemblBacteria" id="OEV33227">
        <property type="protein sequence ID" value="OEV33227"/>
        <property type="gene ID" value="HS99_0039270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198531" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="8973" checksum="E28961A83867580F" modified="2017-01-18" version="1">MTGVPLTAVPARRPSTVQAAPPKASPAKASPAKASPPAESATAPGGAGPGDLDELARRLVEPVGRLLRTELRRGRERAGRPYDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU5</accession>
    <name>A0A1E7MXU5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase M38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554149.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000819.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5909"/>
    <dbReference type="EnsemblBacteria" id="ARF82071">
        <property type="protein sequence ID" value="ARF82071"/>
        <property type="gene ID" value="B6264_27180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33234">
        <property type="protein sequence ID" value="OEV33234"/>
        <property type="gene ID" value="HS99_0039130"/>
    </dbReference>
    <dbReference type="OMA" id="GVTICHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="43084" checksum="5C053F80AA49B072" modified="2017-01-18" version="1">MNRLLITNAHLLHPEDGTRTDPGWLEAADGRITATGTGRPPAATDGVRVVDAQGGTVLPGLIDAHVHLLVTSLDLRDFANWTPGYATVRALAEAERMLRRGFTTVRDVGGADHGMARALAEGLVPGPRLLHGGKALSQTGGHGDLRPLGEDALPCCEARPNFGRIADGVDAVRAAARDEFRKGARHLKVLLSGGVASPHDEIAAVQYSEEEIRAAVEEAENHNRYVTVHAYHPRAIDRALRAGVRCVEHGNLLDDTTVALLLEKDAFLVPTLVAYEQTARLGAASGLPPASVGKLAEVRDRGLEALERAHRAGVNLVYGSDLLGPLHPAQLEEFTLRAQVQPVADVLRSATTTAARLLGMEGEIGTLAPGAHADLLVVDGDPLADLAVLTRPEEHLRYVVKAGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY33</accession>
    <name>A0A1E7MY33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385401.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3402"/>
    <dbReference type="EnsemblBacteria" id="ARF80443">
        <property type="protein sequence ID" value="ARF80443"/>
        <property type="gene ID" value="B6264_17385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33342">
        <property type="protein sequence ID" value="OEV33342"/>
        <property type="gene ID" value="HS99_0012155"/>
    </dbReference>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="475"/>
            <end position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="686" mass="72825" checksum="C5AE4A90390FD216" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYG3</accession>
    <name>A0A1E7MYG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6619"/>
    <dbReference type="EnsemblBacteria" id="ARF80580">
        <property type="protein sequence ID" value="ARF80580"/>
        <property type="gene ID" value="B6264_18190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33477">
        <property type="protein sequence ID" value="OEV33477"/>
        <property type="gene ID" value="HS99_0012970"/>
    </dbReference>
    <dbReference type="OMA" id="TCYDRRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="18669" checksum="1FFE46C04EAF9AF5" modified="2017-01-18" version="1">MCLNRKDLGLLALRSAVGGVLIAHGTQKLFGWFGGGGLEGTTQAMDHMGFHPARESAIAAGVGEAGGGALLVAGLATPAAGAVVAGTMAGAVAVHAPAGFFAMSGGYEYPAFLGATGLAIGLAGPGRYSLDHLTGHVFDRSWVGLLAFVGSAAGAYGVVARRRHLVRLREERAAVEAEQQEGSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU4</accession>
    <name>A0A1E7MYU4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288749.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6586"/>
    <dbReference type="EnsemblBacteria" id="OEV33594">
        <property type="protein sequence ID" value="OEV33594"/>
        <property type="gene ID" value="HS99_0012805"/>
    </dbReference>
    <dbReference type="OMA" id="GANRSWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="538" mass="57734" checksum="291D7E4185D7C661" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ14</accession>
    <name>A0A1E7MZ14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6602"/>
    <dbReference type="ESTHER" id="kitau-a0a1e7mz14">
        <property type="family name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80566">
        <property type="protein sequence ID" value="ARF80566"/>
        <property type="gene ID" value="B6264_18105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33463">
        <property type="protein sequence ID" value="OEV33463"/>
        <property type="gene ID" value="HS99_0012885"/>
    </dbReference>
    <dbReference type="OMA" id="TPYYYQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008761">
        <property type="entry name" value="Peptidase_S37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05576">
        <property type="entry name" value="Peptidase_S37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="500" mass="55262" checksum="ABF33C0E3803AADD" modified="2017-01-18" version="1">MTTKLKRLLVSVLLIPMFAITGLATPAAAATAGQGSEAAAAAHGRSPADDPNADIKDRLAAIPGVTITGEQPTTTGHRYFLATYTQPIDHFRPWLGTFQQRFSVLHRGYDRPTVFYTNGYTLGTTPSRTEPTRLVDGNQVSIEYRFFTPSRPDPADWSKAGIRQQAADSHKLVTALKRIYQQEWLSTGASKGGMSSTFYRRFYPDDVAGTIAYVAPNNTDVNDYSAYTDFFRNVGTPECRAKLNAAQRELLVRRDRLEPRYIADNKAAGSTFNTLGTPDRAYEAGVLDVVWAFWQYSLEADCAKVPVAATATDDELYAWYDAQSGITGNSDQSLAKYTAYYYQAATELGAPFFDVSYLKDQLHYDYKELYSARSYVPKEIPTVFNPYAMPDIDRWVKREGERIMFVYGGNDPWGAKPFRLGRGSDDSYVYVVPGGNHGSNIGKLPAEQSAEATAKVLEWAGLDDQAAAAARSLAKSPQVGAPFGPLDVEGQRLEQERRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF3</accession>
    <name>A0A1E7MZF3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0012995</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6624"/>
    <dbReference type="EnsemblBacteria" id="OEV33603">
        <property type="protein sequence ID" value="OEV33603"/>
        <property type="gene ID" value="HS99_0012995"/>
    </dbReference>
    <dbReference type="OMA" id="WALRRDW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="324"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="516" mass="56797" checksum="DC3CF1CBC1C947F7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF6</accession>
    <name>A0A1E7MZF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0037485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557798.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000268.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4408"/>
    <dbReference type="EnsemblBacteria" id="ARF80325">
        <property type="protein sequence ID" value="ARF80325"/>
        <property type="gene ID" value="B6264_16685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33835">
        <property type="protein sequence ID" value="OEV33835"/>
        <property type="gene ID" value="HS99_0037485"/>
    </dbReference>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="47304" checksum="D016D1D284933672" modified="2017-01-18" version="1">MATVLTVVGILVFVVGLLFSIAWHELGHLSTAKLFGIRVPQYMVGFGPTIWSRRKGETEYGIKAIPFGGYIRMIGMFPPGEDGRITKRSSSPWRTMIEDAREASYEELQEGDENRLFYTRKPWKRVIVMFAGPFMNLVLAFGLFLTVMMGFGVTMAVPTIGSVAQCVVKAGQPTDTCPADAPKTPANEVGLRQGDKVLSFDGDRIRDYDQLQADIRRSAGKQVEVVVDRDGQRLTFRPTIAVNDVQKYDGNGVPVKGQTVQAGFLGFTPRSETVQLGLGQSIDRMYGMAENGVKSLAALPGKIPGLWNAVVGNAPRDPDSPIGMVGAARVSGEVFSLHESAAQRVAIFVNLLAGINLSLFLFNMLPLLPLDGGHIAGAVWESVRRRFARLFRRPDPGPFDVARLMPVAYVVASIFIGFTLLVMVADLVNPVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK6</accession>
    <name>A0A1E7MZK6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385373.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4390"/>
    <dbReference type="EnsemblBacteria" id="ARF80308">
        <property type="protein sequence ID" value="ARF80308"/>
        <property type="gene ID" value="B6264_16590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33851">
        <property type="protein sequence ID" value="OEV33851"/>
        <property type="gene ID" value="HS99_0037580"/>
    </dbReference>
    <dbReference type="OMA" id="PCELSSP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="48382" checksum="458405440EE0FE79" modified="2017-01-18" version="1">MREALRTGGQGLGRLAQAVLGALPGFVLPVGAAIFSGVVTSRFLEYYYAAPLVALALAAVVGAAVAALCVRRTADRTRRFLQRWYGIRLPAVYDPLPKLESDERGHWWTGYSYHRSGTVARYAQLVHWGLRDRTTRAELLWLVVNPVLVLALGGAVGLLLVLGTAFALSGPVPANAFGPVSPRLTSMALSLLVGIGMVLAGILLAPYAVRGYAEVARRVLDQDGRATHAQLTKRVAELTETRADAVGSQAAELRRIERDLHDGAQARLVAIGMTLGTIEHLMETDQDAARELLSEARQSSARALQELRDLVRGIHPPVLAERGLGDAVRALALDSALPTEVFVSLPDRLPAPVEAAAYFSISELLANAAKHSAAERVWVDILYRAGSLRITVTDDGVGVADPSRGTGLRGIERRLGTFDGVLAIDSTSGGPTTITLELPCELSSPRTSTSSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP0</accession>
    <name>A0A1E7MZP0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552238.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1840"/>
    <dbReference type="EnsemblBacteria" id="ARF77749">
        <property type="protein sequence ID" value="ARF77749"/>
        <property type="gene ID" value="B6264_01350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33906">
        <property type="protein sequence ID" value="OEV33906"/>
        <property type="gene ID" value="HS99_0010510"/>
    </dbReference>
    <dbReference type="OMA" id="NMVFPRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="45929" checksum="4CFC1F66EE7CA74A" modified="2017-01-18" version="1">MDDYRLIADEVAADITSGRLRPGQQLPTQRAFARRRGIAASTAGRVYRELVRRGLTVGEVGRGTFVRAGGRSGENGRIALAEPATAPIDLELNYPSAPGQAELLAGALTPLLRADALEEALRPVGAAGTDAARQSFAGLLTAGTGGWEVEARGLLFAGNGRQAVAGALAALVAPGQRLGVEALTYPVVKAVAGRLGVRLVPLAVDEHGLRPDAVAAAHRTAPLSAVYLQPRLQNPLGTSLPPERAVALAAELRRLDLPVVEDAIWSFLRPELAPLAALAPERTVLVDSLSKRLAPGLTVGFAVVPDGLRERVAGALRTGGWTPSGFALEAAVRWIADGTLAAVTAAKRTDAAARQALAREALAGQRLRADPCSYYLWWELPGSWRAEAFVAAAARAGISVTPAAAFAVDPRSTPSAVRVGLASPPLPVLAWALRVLAGIADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N072</accession>
    <name>A0A1E7N072_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551866.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000956.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77941">
        <property type="protein sequence ID" value="ARF77941"/>
        <property type="gene ID" value="B6264_02485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34082">
        <property type="protein sequence ID" value="OEV34082"/>
        <property type="gene ID" value="HS99_0011630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14691" checksum="E4942E8E38E96E7D" modified="2017-01-18" version="1">MPSGTWTSYRDVGVWEQQGGRADETSRFPMLDTGTPSQPHLLWPLALYPVTGATEVVFQCLKDRSPFDDAEIGRELLRRFDEIDGIELAEANWTSARPSRSRCSPTTRRRSARCWSSRSAPEPDCCAAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L1</accession>
    <name>A0A1E7N0L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285711.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6051"/>
    <dbReference type="EnsemblBacteria" id="ARF78144">
        <property type="protein sequence ID" value="ARF78144"/>
        <property type="gene ID" value="B6264_03745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34228">
        <property type="protein sequence ID" value="OEV34228"/>
        <property type="gene ID" value="HS99_0036845"/>
    </dbReference>
    <dbReference type="OMA" id="DHQVVRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="23919" checksum="16AC2C0070AF196D" modified="2017-01-18" version="1">MPESTPSIRVLLVDDHQVVRRGLRTFLEVQDDIEVVGEAADGAEGVERARELDPDVVLMDLKMPGVDGIEALRTLKGGGSRARILIVTSFTEHRTMVPALRAGAAGYVYKDVDPEALAGAIRSVHAGHVLLQPELAEALLADEGPRAPQGRGGTLTEREREVLGHIADGRSNREIARSLHLSEKTVKTHVSNILLKLDLADRTQAALWAVRNGETREAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L9</accession>
    <name>A0A1E7N0L9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285720.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6047"/>
    <dbReference type="EnsemblBacteria" id="ARF78140">
        <property type="protein sequence ID" value="ARF78140"/>
        <property type="gene ID" value="B6264_03725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34224">
        <property type="protein sequence ID" value="OEV34224"/>
        <property type="gene ID" value="HS99_0036825"/>
    </dbReference>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="37702" checksum="AF59FEDDCD4C5EC6" modified="2017-01-18" version="1">MEPVLIVLVVLVVVAFIALIKTIQVIPQASAAIVERFGRYTRTLNAGLNIVVPFIDRVRNRIDLREQVVPFPPQPVITQDNLVVNIDTVIYYQVTDPRAATYEVASYIQAIEQLTVTTLRNIIGSMDLESTLTSREVINAGLRGVLDEATGKWGIRVNRVELKAIEPPTSIQDSMEKQMRADRDKRAAILTAEGQRQAQILKAEGEKQADVLRAEGEAQAAVLRADGEAAAIRTVFEAIHDGDADQKLLAYQYLQTLPELAKGDSNKLWIIPSEVGDALKGLGGAFTGLAGNGGGANGGAVAAPSVPQTPPAATQVPIDPAAGPRPVDVEKGAARPRVDPAREYRKIDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N164</accession>
    <name>A0A1E7N164_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Stearoyl-CoA 9-desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0035630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552306.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000353.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1077"/>
    <dbReference type="EnsemblBacteria" id="ARF78964">
        <property type="protein sequence ID" value="ARF78964"/>
        <property type="gene ID" value="B6264_08565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34439">
        <property type="protein sequence ID" value="OEV34439"/>
        <property type="gene ID" value="HS99_0035630"/>
    </dbReference>
    <dbReference type="OMA" id="SCGESWH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="36673" checksum="9FD3312924A55F6C" modified="2017-01-18" version="1">MTIQAGEERAGAAALPDPSSDPSADAATRLSATRGGEKQGLAERIALALFILVPFAALVAAVPVAWGWGLGWTDAAVTVAMYFLTCHGITVGYHRYFTHGAFKASRPMRLVLAIAGSLAVEGPLVRWVADHRKHHRFSDKDGDPHSPWRYGESVPALIKGLWWAHMGWMFDEEQTPHLKYAPDLVGDPAMRRISRLFWLWTTISLLLPALVGGLVSLSWQGALSAFFWGSLVRVALLHHVTWSINSICHAIGRRPFRSRDRSGNVWWLAVLSCGESWHNLHHADPTSARHGVLRGQIDSSARLIRWFELAGWVRDVRWPDPQRIAARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F7</accession>
    <name>A0A1E7N1F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2574"/>
    <dbReference type="EnsemblBacteria" id="OEV34514">
        <property type="protein sequence ID" value="OEV34514"/>
        <property type="gene ID" value="HS99_0035545"/>
    </dbReference>
    <dbReference type="OMA" id="DAWCAPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="40081" checksum="6A06535352831A8E" modified="2017-01-18" version="1">MQIGIFSVGDVTVDPATGRAPSERERIKAMLTIALKAEEVGLDVFAMGEHHNPPFVPSSPTTMLGWIAAKTERIILSTATTLITTNDPVKIAEDYAMLQHVADGRIDLMLGRGNTGPVYPWFGQDIRQGIPLAVENYALLHRLWREDVVDWEGRFRTPLQAFTATPRPLDGVPPFVWHGSIRSPEIAEQAAYYGDGFFANNIFWPQEHTRRMVGLYRERFAHYGHGTPEQAIVGLGGQVFMRKNSQDAVREFRPYFDNAPVYGHGPSLEEFTEQTPLTVGSPQEVIERTLGFREAVGDYQRQLFLMDHAGLPLKTVLEQLDILGEEVVPVLREEFAKGRPATVPDAPTHATLRDAVPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1P3</accession>
    <name>A0A1E7N1P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34619">
        <property type="protein sequence ID" value="OEV34619"/>
        <property type="gene ID" value="HS99_0008965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17194" checksum="6B7AFA4D81DA125B" modified="2017-01-18" version="1">MPDGAGLDELHAHLVRLVVALPGVGHVLAADVEAELRGGRGAVCHGLEFGEDGVVHGEYRVGPLQHAVVDLDRAVVADVVAGFLGGPDGVAVRRAADVALAQPGRADLDLLPADVGEHRGGERRAVVVAQADHQDAVALRVAERLAHLRLLGVGHEVALIASASAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q2</accession>
    <name>A0A1E7N1Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554763.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000116.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4283"/>
    <dbReference type="EnsemblBacteria" id="ARF82022">
        <property type="protein sequence ID" value="ARF82022"/>
        <property type="gene ID" value="B6264_26860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34612">
        <property type="protein sequence ID" value="OEV34612"/>
        <property type="gene ID" value="HS99_0008930"/>
    </dbReference>
    <dbReference type="OMA" id="CDILSCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12818" checksum="479ED46D40F438C9" modified="2017-01-18" version="1">MSAKLDYRWHLRKVMADHGMFSTTDLIPPLAERGITLSTSQVYRLVVERPERLSLKILMALLDILDCRMDDLVEPIASATAVKKPKTAAAAGTAPPAADGLGDLRPKRARIRGVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1S3</accession>
    <name>A0A1E7N1S3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82019">
        <property type="protein sequence ID" value="ARF82019"/>
        <property type="gene ID" value="B6264_26840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34616">
        <property type="protein sequence ID" value="OEV34616"/>
        <property type="gene ID" value="HS99_0008950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="7908" checksum="D4D3F0E0BF9EA1AB" modified="2017-01-18" version="1">MLVCRLEGELGARALQQDLRPGDRVAVRGRLAVRYYRGDDGIPRSATLFHADGFGPFLGCRPSRPPGGPAGSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U4</accession>
    <name>A0A1E7N1U4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554692.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4245"/>
    <dbReference type="EnsemblBacteria" id="ARF81982">
        <property type="protein sequence ID" value="ARF81982"/>
        <property type="gene ID" value="B6264_26635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34652">
        <property type="protein sequence ID" value="OEV34652"/>
        <property type="gene ID" value="HS99_0009145"/>
    </dbReference>
    <dbReference type="OMA" id="IEAGPFH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="30708" checksum="45654419991E3C79" modified="2017-01-18" version="1">MSTAITFSEYGAPEVLQLSEVALPQPGPGQVRIRVRAASVNPLDMKIRSGLMAKVAPARFPMIPGLDAAGVVDAVGEGAGAAVGDEVLGATVGGSYSEYALIERPVAKPEALSWEVAASLVTVGQTAHRVLGQLGVQAGQTLLVHGAAGSVGFIAVQLAAARGITVIGTVSEKDIERVTALGATAVRYGDGWAERVTAAAPGGVDYVFDASGAGVLADSVALTGDAAKVITIADMSAQQHGVRFSAGTTDQGTDALPELVHLVAEGRLTVPIWRTYPLAETAQAHADLEAHRNHGKAVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V3</accession>
    <name>A0A1E7N1V3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554660.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000466.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4225"/>
    <dbReference type="EnsemblBacteria" id="ARF81971">
        <property type="protein sequence ID" value="ARF81971"/>
        <property type="gene ID" value="B6264_26545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34664">
        <property type="protein sequence ID" value="OEV34664"/>
        <property type="gene ID" value="HS99_0009230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="25429" checksum="7ACFA888D87A95D2" modified="2017-01-18" version="1">MAPVITSISPTSGHSGQTMTITGTGLGSLSTTKVNIGTKTVTPTTASNTSVTFAIPSGCSGQANVTATVSGVNSNSSAFFYVAAPTVTSLNPSTGPAAPGAIDVFGTGFATATSVAFDAIGTAVPTVLSDSHLSVTPPAHGAFTACTDAADVIVSSSGGTSSPIGAAGQFIYYALPTVTSVTPNTGPAGTTGVIVTGTCFVDVSSVTFTPVGGGASTPADNVSLIGVGSLTLDVPTLAAGTYDIQVTNPGGTSAAVAADHFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W9</accession>
    <name>A0A1E7N1W9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737933.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4215"/>
    <dbReference type="EnsemblBacteria" id="ARF81965">
        <property type="protein sequence ID" value="ARF81965"/>
        <property type="gene ID" value="B6264_26505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34671">
        <property type="protein sequence ID" value="OEV34671"/>
        <property type="gene ID" value="HS99_0009270"/>
    </dbReference>
    <dbReference type="OMA" id="KDVQHYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2171" mass="227304" checksum="F0A473B323BA0A36" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F1</accession>
    <name>A0A1E7N2F1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0010285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737942.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7614"/>
    <dbReference type="EnsemblBacteria" id="ARF81793">
        <property type="protein sequence ID" value="ARF81793"/>
        <property type="gene ID" value="B6264_25435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34845">
        <property type="protein sequence ID" value="OEV34845"/>
        <property type="gene ID" value="HS99_0010285"/>
    </dbReference>
    <dbReference type="OMA" id="APTHLVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="40997" checksum="3915AB52B5D1698A" modified="2017-01-18" version="1">MLSVTALPSRRRLNALGRRGAFRLHASVLVALLAASSAPTPLYALYQAAWHFSAMTLTVVFSAYALALLVALLTAGTLSDHLGRRPVLAGALLAEAVAMTVFATAQGVPALIAARILQGLATGVATSAAGAALLDFEDPDRPGRATVANGITPVAGMAVGVLAATALVQYAPAPTRTVYLPLLLLFTAQAAAVLLTPETAHPHPGAWRSLRPAITVAPASRPTLALTTPGIVAAWALGGFYSSLGPSLARLIDPHAARATGGLVFFTLTAAAGIAGHTARALPARTVSLAGTALLIPGALLTLSSPQLHSLPALFAGTAVAGAGFGAVTQGALRLLLPPAAPGERAGTLAAYYVLSYLAMSIPAVLAGLLTNLYGLQKAVSLYAATVVLLALIGLTRAVRRPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2H1</accession>
    <name>A0A1E7N2H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4621"/>
    <dbReference type="EnsemblBacteria" id="OEV34882">
        <property type="protein sequence ID" value="OEV34882"/>
        <property type="gene ID" value="HS99_0009640"/>
    </dbReference>
    <dbReference type="OMA" id="GTRWAVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="38364" checksum="6A1CA083538F2913" modified="2017-01-18" version="1">MAGLIAPLERKYGWSLAERAGEDCPDGMQRLLNSADWDADTVRDDVRDFVVETIGDSNAVLIGDDTGFLKKGIRSAGVQRQYTGTAGRTENCQIGTFLAYASTKGRALIDRELYLPASWTDDRARCRAAGIEDDVPFATKIEHFRAMLQRALDAKVPFAWVTADEAYGQVKTLRFWLEERRVAHVPATKVNDTVITTGGADARVDQLIAALPRQAWKRLGAGPGAHGQRIYDWARVPIRIYRENGFGHWVLARRSVSDPTEIAHYVCYGPADTRLTDLARIAGARWQVEECFQTAKNECGLDHYQVRRYQAWYRHITLSMAALACLTAIRAHELAKGAPDPTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J1</accession>
    <name>A0A1E7N2J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000839.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5851"/>
    <dbReference type="EnsemblBacteria" id="ARF77559">
        <property type="protein sequence ID" value="ARF77559"/>
        <property type="gene ID" value="B6264_00225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34902">
        <property type="protein sequence ID" value="OEV34902"/>
        <property type="gene ID" value="HS99_0034875"/>
    </dbReference>
    <dbReference type="OMA" id="WRWTSHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="32310" checksum="320D2FFAA83A2351" modified="2017-01-18" version="1">MTTVNTGAPDVADEPTGQHAPATEARSANAARPARDGRIRRGIGMAAMIAVGVGAIGLGTGVSPAAAERAPAHAGWDGSRYWFKDSQGQWRWTSHYSVYLARTGGAESSSKSTSKSSSAASSTSSSKSSNGGIKPGWDGSRYWFKNTKGEWRWTSHYDVYLQRTGGSSGGSSSSGSSGGASSGSVAADRNVEAAVQYALAQLGKPFRTAGNGPDGYDCSGLVQQSFRRGGIALPRVANDQYAATTPIKASQLRRGDLLFWSPNGTARGIQHVAIYLGNNQYVEAARPGTRIRISSISKGYYPAFMGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L3</accession>
    <name>A0A1E7N2L3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737926.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34905">
        <property type="protein sequence ID" value="OEV34905"/>
        <property type="gene ID" value="HS99_0034890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025238">
        <property type="entry name" value="DUF4184"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13803">
        <property type="entry name" value="DUF4184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="124" mass="12751" checksum="AFC1D4471F670B93" modified="2017-01-18" version="1">MPFTLSHPAAVLPLLRAAGERGPLVASALVAGSMAPDVPFFAESLLPGVYGRGGLTHAWWAVPTLDVAIAGALVAGWHGLLRARSATRRWSRPPAGGVAGGPEPVRTRVSWSAVRRSGGGTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3J1</accession>
    <name>A0A1E7N3J1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3-diaminopropionate biosynthesis protein SbnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0033605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289525.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6127"/>
    <dbReference type="EnsemblBacteria" id="ARF79314">
        <property type="protein sequence ID" value="ARF79314"/>
        <property type="gene ID" value="B6264_10640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35250">
        <property type="protein sequence ID" value="OEV35250"/>
        <property type="gene ID" value="HS99_0033605"/>
    </dbReference>
    <dbReference type="OMA" id="PETHYRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023927">
        <property type="entry name" value="SbnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03945">
        <property type="entry name" value="PLP_SbnA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36487" checksum="55349822FA137D4F" modified="2017-01-18" version="1">MPIIRTPQEFNEDDLFVDLRAMFDYPLYLKCEGFNFAGSVKLKAALSMVDAAERDGRLNRDSVLVESSSGNLGMALSMIASVRGYQFICVVDPRTNLSTRQLIETLGGHVHMITEPSPETGFLGARLDYVRELCASSPRYVWLNQHANPDNWRAHYRTTGPSILRQFPELDVLFVGAGTTGTLMGCARYFKEHRPATRVVAVDSVGSVTFGGEPGPRMIPGLGAGVRPALLDEDFVDDVVHVPEVDTVRTCHRLARGGFLFGGSTGTVVSGAAAWLEKHREGKDVVAVAVSPDLGDRYLDTIYQSAWVRDIYGADALDAVERLTPPNAIVTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P0</accession>
    <name>A0A1E7N3P0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282783.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5298"/>
    <dbReference type="EnsemblBacteria" id="ARF80711">
        <property type="protein sequence ID" value="ARF80711"/>
        <property type="gene ID" value="B6264_18965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35285">
        <property type="protein sequence ID" value="OEV35285"/>
        <property type="gene ID" value="HS99_0033025"/>
    </dbReference>
    <dbReference type="OMA" id="SERWRCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="87" mass="9628" checksum="68F8B1AA5341A440" modified="2017-01-18" version="1">MTVPALTAETRWRCTLCGNLTRFDVTRTARVTEFLHFDLAGESEVEETEVLSETIESVRCRWCNAVDQVELVARPGAEGAEAPAEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3W3</accession>
    <name>A0A1E7N3W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35378">
        <property type="protein sequence ID" value="OEV35378"/>
        <property type="gene ID" value="HS99_0032720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7284" checksum="9D83AA9EBBCF37C4" modified="2017-01-18" version="1">MGGSSGAEAQPRERTVPGTASAREGYQPDHGTGSGSPLEGVEIDPDEQQEIHPSDDEDQPDAGPVRRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3W6</accession>
    <name>A0A1E7N3W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278615.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000493.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2378"/>
    <dbReference type="EnsemblBacteria" id="OEV35388">
        <property type="protein sequence ID" value="OEV35388"/>
        <property type="gene ID" value="HS99_0032800"/>
    </dbReference>
    <dbReference type="OMA" id="MDEPCAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29582" checksum="4CB42FF3D1C09E9E" modified="2017-01-18" version="1">MSPSFDGPLLRTQDVDVVRDGRHLLRGITLEIRPGEHWALLGPNGAGKSTLLALLGAVSHPTRGTVDVLGRRLGRVDVRELRAHLGHVNPRHPLRSPLSVREVVLTGSTNTIEPEWHRKPAPEAVERAEQLIETLGMGAMAEAPWTTLSQGERGRALIARALMPSPRLLLLDEPATGLDLTARELLLDSLDLLRHQHPELASVLVTHHLEELPESTTHALLLRGGECVAAGPVDEVMTTGLISETFGHPIRISRHEGRWTARAAARRAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y4</accession>
    <name>A0A1E7N3Y4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366986.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3460"/>
    <dbReference type="EnsemblBacteria" id="OEV35397">
        <property type="protein sequence ID" value="OEV35397"/>
        <property type="gene ID" value="HS99_0032845"/>
    </dbReference>
    <dbReference type="OMA" id="YLAWFGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="33604" checksum="F12190573F822A69" modified="2017-01-18" version="1">MTIPAPQHPERPAGWISTGLSWHDGRALLGAVRGGRVHERAVAPGTEVGWLLGGPRRCTGAWLAGATERTPCPHHAEIAPDGGATQCPACQSVDRGLALARDQILDDGRTYLLYLAWFGEGLLKVGLTAEQRGDSRLLEQGALAYAFTARGGLPAVRRAELTVAASGMARERYKSRLKTDHWWSHGDAPHRRTVLTEARARAHGLLKGHAVELLADRPVVDHVERFGLADGAPEVYREITGLAPGAVIAGTLRPPVGRHLFLDQPDGSGPLLLDTRRLTGWALTPVTGRAPEGLALQERVRPPEPDTQEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N453</accession>
    <name>A0A1E7N453_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3895"/>
    <dbReference type="EnsemblBacteria" id="OEV35466">
        <property type="protein sequence ID" value="OEV35466"/>
        <property type="gene ID" value="HS99_0032425"/>
    </dbReference>
    <dbReference type="OMA" id="LHLRVCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013630">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038576">
        <property type="entry name" value="Methyltransf_Zn-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013691">
        <property type="entry name" value="MeTrfase_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08421">
        <property type="entry name" value="Methyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08484">
        <property type="entry name" value="Methyltransf_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198734" evidence="1">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_13" evidence="2">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_14" evidence="3">
        <location>
            <begin position="244"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="411" mass="44937" checksum="6DC3EE0A1023B1B3" modified="2017-01-18" version="1">MTRCRLCGSAALASVVDLGATPPCESFLAADELDRPEPAYPLHLRVCTDCWLAQLPPLITPEETFTQYAYFSSYSTSWVEHARSFVDGAVRRLGLGPDAFVVEVASNDGYLLRHVVDRGIRCLGIEPSVNVGAAAREAGVPTLTEFLSPDTGAAVRAEHGPADLVVANNVYAHIPDVVGFTRGLRALVADDGWVSIEVQHLLTLIEENQYDTIYHEHFQYYTVASAARALASGGLTLVDVELLPTHGGSVRLWARPAEAAGEPGRRVAEVLDREKAAGLQELSGYTEFSARVAKVRRDLLRFLIDAAERGETVVGYGAPGKGNTLLNHCGIRPDLLPYTVDRNPYKHGRFTPGTRIPVLAPEQIAVDRPDYVLVLPWNLRAELVEQLSFVHEWGGRLVFPVPELSIVEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N469</accession>
    <name>A0A1E7N469_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552781.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5538"/>
    <dbReference type="EnsemblBacteria" id="ARF79376">
        <property type="protein sequence ID" value="ARF79376"/>
        <property type="gene ID" value="B6264_10975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35488">
        <property type="protein sequence ID" value="OEV35488"/>
        <property type="gene ID" value="HS99_0031780"/>
    </dbReference>
    <dbReference type="OMA" id="AKHINEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="19339" checksum="1385FB1061C2DD7D" modified="2017-01-18" version="1">MSVSRRLLATALVATAAFGLAACGPDDSSGQGAGTAGATAAPATAPATGAPASGAPASGTAKPAPSGKPTDGAPEGFCTSDPLPAGQKWVIVQKGTSATALVYKESKDACGVDDVAHEPTGADKTAQFSPTVKGHLRSVVAAPKDVNAADLAKHINECIATPGNQKGFYPCSNGDYKIAVDASGKVTEMWERPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P2</accession>
    <name>A0A1E7N4P2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551171.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene921"/>
    <dbReference type="EnsemblBacteria" id="ARF80852">
        <property type="protein sequence ID" value="ARF80852"/>
        <property type="gene ID" value="B6264_19800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35659">
        <property type="protein sequence ID" value="OEV35659"/>
        <property type="gene ID" value="HS99_0007030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="14236" checksum="E3B2229BF92D82D4" modified="2017-01-18" version="1">MSRNSSTIWLPRSRRSPAIARQRLSVLLSSTPNGDRFLDSGLVVTTEFVTNAVLHGTPIGHLIYFALDVDPTRLRIEVHDARGDRLPALSSPGLDGETGRGLHLVDSLTKRWGCCPRRPVGKIVWGEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4T0</accession>
    <name>A0A1E7N4T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0007230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene880"/>
    <dbReference type="EnsemblBacteria" id="OEV35690">
        <property type="protein sequence ID" value="OEV35690"/>
        <property type="gene ID" value="HS99_0007230"/>
    </dbReference>
    <dbReference type="OMA" id="PYYQGDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="583" mass="60911" checksum="703749FC546EB71B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N500</accession>
    <name>A0A1E7N500_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281589.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80926">
        <property type="protein sequence ID" value="ARF80926"/>
        <property type="gene ID" value="B6264_20235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35724">
        <property type="protein sequence ID" value="OEV35724"/>
        <property type="gene ID" value="HS99_0007465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18533" checksum="D048DEDC303DC51C" modified="2017-01-18" version="1">MFFSVGWAVLLAAVVVPPLVVGPAFARSGALIASGLVAALGPAVLLEAATARRRSVRVAGGVVRARTWSGEREVDLRDLAIVRAWEAISRDGARTFVSLADRSGGWVVLLADGGRRQLIADAVRRHGAGYVSPWALGLLGLEPTRWYAAGGRVLGLLFVFVALLPAGMLLAAAVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5G3</accession>
    <name>A0A1E7N5G3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="17" type="ORF">HS99_0006640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280428.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5386"/>
    <dbReference type="EnsemblBacteria" id="ARF82932">
        <property type="protein sequence ID" value="ARF82932"/>
        <property type="gene ID" value="B6264_19405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35936">
        <property type="protein sequence ID" value="OEV35936"/>
        <property type="gene ID" value="HS99_0006640"/>
    </dbReference>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OEV35936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="435" mass="45617" checksum="E0318FF1AB7A4BB7" modified="2017-01-18" version="1">MISRIDLRGSLDDPRDLLPRAEFDVAAALEKVRPIAEDVRHRGVAALIEITERFDGVRLESTRVPAEQLTAALETLDPRVRAALEESIRRARAVHADQRRTGHTTQVVPGGTVTQRWVPVERVGLYVPGGLAVYPSSVVMNVVPAQEAGVKGIAVTSPPQKEFGGRVHPTILAACALLGVDEVYSVGGAQAVAMFALGTEECAPVNMVTGPGNIYVAAAKRLFAGRIGIDSEAGPTEIAVLADDSALPSDVAADLISQAEHGPTSGSVLVTDSPELADAVEAELAVQVARTKHTERVAEALGGRQSGIILVDDLTQGLAVVNAYAAEHLEIQTRDPHAVAARVVNAGAIFIGRWTPVSLGDYAAGSNHVLPTGGCACHSSGLSVQTFLRGVQVVEYDRDALAEVAAHVVTLADAEDLPGHGDAIKARFDWTVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R6</accession>
    <name>A0A1E7N5R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000564.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78802">
        <property type="protein sequence ID" value="ARF78802"/>
        <property type="gene ID" value="B6264_07635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36032">
        <property type="protein sequence ID" value="OEV36032"/>
        <property type="gene ID" value="HS99_0031490"/>
    </dbReference>
    <dbReference type="OMA" id="MGNIMIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="15715" checksum="02E3F2644CC35E38" modified="2017-01-18" version="1">MGNIMITKMTGQTVVAASLRAARLRALAELGGTGLGLDATGVSVASAVSGLGHTDLCLTGGRSVEGTAVETGLSRDWASVDASRPERDERPTQAPKAAVAAAMHGGYAQVIGAGNAQKQNEQQINQATAAFIGAKAIRMRAFRGPEPWRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N659</accession>
    <name>A0A1E7N659_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284382.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000192.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8122"/>
    <dbReference type="EnsemblBacteria" id="OEV36165">
        <property type="protein sequence ID" value="OEV36165"/>
        <property type="gene ID" value="HS99_0030395"/>
    </dbReference>
    <dbReference type="OMA" id="WVGHARK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="12373" checksum="035E4622A9F90B47" modified="2017-01-18" version="1">MAQRVQVILEDDLDGGSADETVTFALDGVAYEIDLKSANADKLRGLLAPYVEKGRKQSGRLAGARRPGRGTAARPSGSAPDTAKIRAWAKEQGMDVNDRGRVPSTVREAYDKANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E4</accession>
    <name>A0A1E7N6E4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550898.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000157.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2660"/>
    <dbReference type="EnsemblBacteria" id="OEV36262">
        <property type="protein sequence ID" value="OEV36262"/>
        <property type="gene ID" value="HS99_0030090"/>
    </dbReference>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19772" checksum="F87C3E97AE0E93AF" modified="2017-01-18" version="1">MTADLSDLTGDYVLDPAHTRIGFVARHAMVTKVRGAFTEFEGAAHLDGSDPSRCSARVTIQAGSIDTGVAQRDQHLRTNDFLDVPDFPTITFAVTAVEPRGDGEYRVTGDLTIKGTTRPVSIDFEYTGNAVDPMGNLRVGLEGSVTINRKDFGVTWNAALEGGGVLVGEKVVLEFDISAVRQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6P3</accession>
    <name>A0A1E7N6P3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366354.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7180"/>
    <dbReference type="EnsemblBacteria" id="ARF82345">
        <property type="protein sequence ID" value="ARF82345"/>
        <property type="gene ID" value="B6264_28815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36362">
        <property type="protein sequence ID" value="OEV36362"/>
        <property type="gene ID" value="HS99_0029840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="14928" checksum="FCFFB67A8FDD93EF" modified="2017-01-18" version="1">MTVISAALFGTDWRPRLPGGAELLRECAARGWTVVLTGPRPPGVPVLTVADPGGEPVRAALELVDGEPQHAVAVAGSVREVLAARRLGVPCVALETGGDAGSELRAAGAVEVHRDATALLGVLDDSLLARPRAFGRVDAGTGAPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N708</accession>
    <name>A0A1E7N708_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386248.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene219"/>
    <dbReference type="EnsemblBacteria" id="ARF83121">
        <property type="protein sequence ID" value="ARF83121"/>
        <property type="gene ID" value="B6264_28270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36481">
        <property type="protein sequence ID" value="OEV36481"/>
        <property type="gene ID" value="HS99_0029340"/>
    </dbReference>
    <dbReference type="OMA" id="WIRAAVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="51181" checksum="09572CB76A0F84CF" modified="2017-01-18" version="1">MEGFEPYLTGTAPPAEGLRLVSLQTWSFETLADSGIGFGDVVANLAAATDTLLRLPLSGGGADGDVPQRLASGATALPHRLESGERSFAFYRGPLTATPAQALPAPADPRLESAGEALVYLRAHGVFDTGYASAFSLGRTLALADAPFRGKLLEFRKAARRAVRRLATRPELVTSARTVRQAADQLNANPQRAAFDRLISTALPAALARTGADLAAAEHRPAARTAAALPLAAGDLRAQLASERVREVLRESTDPEREPVQDWLAELSRLEMIPFDHLVPDPRMLPPESIRFAHLDAEWIRAAVDGALSVGVGHALDADLNQLAAEVPAPPACAVLIRSELIPNWPRTIMTALAGEDVVEPVHRLHYGSDVLLLLFPRVIDAFALAEPPQGLHFGISDNGTIELRRLTGDIGHPMGDFPEEYGFRRFLRAGGRDVLDVTGDLLTELAAAHERETLSPAQFALQMTKAPQLQLFVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N771</accession>
    <name>A0A1E7N771_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291193.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000557.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79157">
        <property type="protein sequence ID" value="ARF79157"/>
        <property type="gene ID" value="B6264_09700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36540">
        <property type="protein sequence ID" value="OEV36540"/>
        <property type="gene ID" value="HS99_0028885"/>
    </dbReference>
    <dbReference type="OMA" id="RFAMKGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19223" checksum="ABA1953554E811DD" modified="2017-01-18" version="1">MRYVYPSPQPEAAPRATPDEFRAALSQLAAGVSLVTVHDEEDGEDVGMTATSFLSVSLDPPLVLISVREDSRMDEVLSRNDTWAVSVLAEGQKTLGSRFAMKGRLSDRLLFAETPHRRGAHTGAPLVEGALATVECRTEQRIPAGDHLLLVGRVLEATVPAPGGRPLLYFRGGYRTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B6</accession>
    <name>A0A1E7N7B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289703.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7922"/>
    <dbReference type="EnsemblBacteria" id="ARF79112">
        <property type="protein sequence ID" value="ARF79112"/>
        <property type="gene ID" value="B6264_09450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36586">
        <property type="protein sequence ID" value="OEV36586"/>
        <property type="gene ID" value="HS99_0029135"/>
    </dbReference>
    <dbReference type="OMA" id="QRVEFGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13495" checksum="CF39606DA9477BB3" modified="2017-01-18" version="1">MPTGQVKWFNETKGFGFLSRDDGGDVFVHTKALPAGVTVLKPGQRVEFGVVAGHRGDQAMAVQLLDALPSVAAAQRRSADDMAPIVQDLITTLDAVLPGLQRGRYPAKPTGQKLAGLLRAVADQFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B7</accession>
    <name>A0A1E7N7B7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000290.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1436"/>
    <dbReference type="EnsemblBacteria" id="ARF82729">
        <property type="protein sequence ID" value="ARF82729"/>
        <property type="gene ID" value="B6264_09710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36602">
        <property type="protein sequence ID" value="OEV36602"/>
        <property type="gene ID" value="HS99_0028875"/>
    </dbReference>
    <dbReference type="OMA" id="DFAWALC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18872" checksum="AC5AB07BD136F3F0" modified="2017-01-18" version="1">MIELGYSLSNRFPDPPQTDYRTAPVRALRYDLFCGDVYLDAEGAELSTRWGWVPVLDFAWALCDIVEQLDRDPDGSRAARVQTADLDFTQNTELLRFARRFNWVEITATWLRDEPPAVVRHSELRREARDFLQDTLADLFDMHPDLADNPNIWTLQGRFPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7C7</accession>
    <name>A0A1E7N7C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289702.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7921"/>
    <dbReference type="EnsemblBacteria" id="ARF79113">
        <property type="protein sequence ID" value="ARF79113"/>
        <property type="gene ID" value="B6264_09455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36585">
        <property type="protein sequence ID" value="OEV36585"/>
        <property type="gene ID" value="HS99_0029130"/>
    </dbReference>
    <dbReference type="OMA" id="VCMLMGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="8816" checksum="E39FCD4A62DF4857" modified="2017-01-18" version="1">MSSQSADPGDVYVKAGAVVFALGALATLVTFVPLFLHLTPLPTAMYWLSMLMPAGFLAALTGLFLNARAQRRRLEPQQPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7M7</accession>
    <name>A0A1E7N7M7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M43 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene176"/>
    <dbReference type="EnsemblBacteria" id="OEV36473">
        <property type="protein sequence ID" value="OEV36473"/>
        <property type="gene ID" value="HS99_0029545"/>
    </dbReference>
    <dbReference type="OMA" id="MTMNYMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198845" description="Peptidase_M43 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M43" evidence="2">
        <location>
            <begin position="173"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="28128" checksum="5DDEE6507CE29004" modified="2017-01-18" version="1">MSGKQKTLAVLTGTVLAAGLTSPAFGSTAVELGPAHVPLAAAPTGIPVYVHVIHSGDTGRLDEGVVAAQIDHLNATYGGQGEGNTPTPFHFVLAGTDWTDNAAWYTGMTPGSTAEQAMKSALRKGDQGTLNLYTAHLGESLLGWSAFPDAYRSHPTDDGVVILDDSLPGGPATHYNEGNTATHEIGHWLGLFHTFQGGCLPPGDYVDDTPPERTPAYGCPEGRHSCPGGGLDPIHNFMDYSYDSCMTRFTPGQVQLMSNSWTAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P6</accession>
    <name>A0A1E7N7P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278889.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000737.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81491">
        <property type="protein sequence ID" value="ARF81491"/>
        <property type="gene ID" value="B6264_23555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36664">
        <property type="protein sequence ID" value="OEV36664"/>
        <property type="gene ID" value="HS99_0028270"/>
    </dbReference>
    <dbReference type="OMA" id="GGWIITR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="25575" checksum="C44FAD37C85D785F" modified="2017-01-18" version="1">MGRNRGRRLTGRRAVGWVVMVGVVAAGGWIITRPTPGDYIPGLGPSQKDAARTPPVVGTPPPPTDSEGLNAGSLFPAQRLVEAAGYKARRNGIRQGEKCDEVLQDGTQELLKDSGCQAYLIVSFTGVDHPVRSSVTLLRFADQAAAVRAADTLRGKPGAVAFILADTNFAPAPSAGSAKPGSEARVEAVGHYVTVTSSRSGDARPADTASSNPAPSTPTPTASGGEPNLDEATRALSYAAGQPFVWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Y1</accession>
    <name>A0A1E7N7Y1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="9">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0027555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386104.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4802"/>
    <dbReference type="EnsemblBacteria" id="OEV36768">
        <property type="protein sequence ID" value="OEV36768"/>
        <property type="gene ID" value="HS99_0027555"/>
    </dbReference>
    <dbReference type="OMA" id="IGVPNKR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28969" checksum="0A90589665FEDC6F" modified="2017-01-18" version="1">MPDPILPVHLPSRSASAATPAAAVTRRPAGGMFHSWDLSTGVDGPGTRFVAFLAGCPLRCLYCHNPDTWHLRDGRRIRADEIVSEAAKCVEFIRASGGGATVSGGEPLLQPVFTGELLHRFKHDLGLHTALDTSGFLGTRATDALLADTDLVLIDIKSWDRALYRHLTGQRLAPTLDFARRLADLGKEVWVRFVLVPGLTDAVENVEGVAAFAASLGNVTRVDVLPFHKLGVAKWRALGLDCTLADAPVPTGDQTAQARAVFEAHGLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N827</accession>
    <name>A0A1E7N827_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4827"/>
    <dbReference type="EnsemblBacteria" id="ARF83146">
        <property type="protein sequence ID" value="ARF83146"/>
        <property type="gene ID" value="B6264_29330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36841">
        <property type="protein sequence ID" value="OEV36841"/>
        <property type="gene ID" value="HS99_0027680"/>
    </dbReference>
    <dbReference type="OMA" id="GAVEFGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="23881" checksum="983644746B928BA2" modified="2017-01-18" version="1">MRANATATAVRLRLTTVYVLLLTAVASWLATQGHAERARFVRHNSSNVHHMEVGKWWSLFTSGLVVDGVPAWAGIAAVAVVLGLAEWRWGPTRAGAVFASGHVGATLLTEGAMWVMLVARIPGALSRARDVGISYGLVATAGCLLALGPPALRRYGLPALALALAGAWAADQQLADAGHLVALGLGVLASRSPWLLARAARPHPGRTPPPRPHRQGPHRREPSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N858</accession>
    <name>A0A1E7N858_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2526"/>
    <dbReference type="EnsemblBacteria" id="OEV36653">
        <property type="protein sequence ID" value="OEV36653"/>
        <property type="gene ID" value="HS99_0028205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9097" checksum="3B7D984766DED34C" modified="2017-01-18" version="1">MAASVRSIRSRTSLGSIGSIGSIGSLLSIGSVGSVLSIGSVGSVLSVGSAGSVFSAFSACSWLSVGSLLSVRSRWSVRGRRPGRGPSVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8D2</accession>
    <name>A0A1E7N8D2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0027260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286965.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6798"/>
    <dbReference type="EnsemblBacteria" id="ARF78595">
        <property type="protein sequence ID" value="ARF78595"/>
        <property type="gene ID" value="B6264_06435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36955">
        <property type="protein sequence ID" value="OEV36955"/>
        <property type="gene ID" value="HS99_0027260"/>
    </dbReference>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="526" mass="54917" checksum="D7DA2CAE9D0B41C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F0</accession>
    <name>A0A1E7N8F0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6817"/>
    <dbReference type="EnsemblBacteria" id="OEV36967">
        <property type="protein sequence ID" value="OEV36967"/>
        <property type="gene ID" value="HS99_0027170"/>
    </dbReference>
    <dbReference type="OMA" id="HNEQAYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="33256" checksum="1AE0503A10203575" modified="2017-01-18" version="1">MVSCTPTVALLDAREWLAGSGTMLRRLRDEHGAVLLRGFSPLDADGLGELATAMSGGLLDYNNRSTPRTRVSGNVFTSTEYPADQTIPLHNEMSYTDAWPDTLFFACVVPAEEGGETPFADSARVYDRVPAGIRERFERHGVMYVRNFGHGVDLSWQEAFQSEDRDEVDAYCREHGMQTEWLGGDRLRTRHVVQATTVSRTTGRKVWFNQAHLFHVSSLPGGVEKVLRESFAEDELPRNALYGDGSPLDPADLAGIRAAYAAEEIAFPWQSGDIVIIDNEQFAHGRRPYSGTRSTLVAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8G8</accession>
    <name>A0A1E7N8G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6469"/>
    <dbReference type="EnsemblBacteria" id="OEV36958">
        <property type="protein sequence ID" value="OEV36958"/>
        <property type="gene ID" value="HS99_0026835"/>
    </dbReference>
    <dbReference type="OMA" id="QITRMEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="16404" checksum="63B68AD41CA6D945" modified="2017-01-18" version="1">MWRAHLEVAKLLDYQLSRELQPHNLAINDYEILVVLSEAPDHRMRMTDLATATLQSKSRLSHQITRMENAGLVLRQECPGDRRGLYAHLTEQGWETMQRVAPDHVRSVRAHFIDRFTPEQLDAIYEALAPVAEHLRGLRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8N6</accession>
    <name>A0A1E7N8N6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0004065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5965"/>
    <dbReference type="EnsemblBacteria" id="OEV37014">
        <property type="protein sequence ID" value="OEV37014"/>
        <property type="gene ID" value="HS99_0004065"/>
    </dbReference>
    <dbReference type="OMA" id="AMTPTMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="PTHR11452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198874" description="Alpha-galactosidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="7">
        <location>
            <begin position="415"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="549" mass="57053" checksum="DEB919CA9810CC26" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N903</accession>
    <name>A0A1E7N903_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein mbtH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386617.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6814"/>
    <dbReference type="EnsemblBacteria" id="ARF78609">
        <property type="protein sequence ID" value="ARF78609"/>
        <property type="gene ID" value="B6264_06510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36943">
        <property type="protein sequence ID" value="OEV36943"/>
        <property type="gene ID" value="HS99_0027185"/>
    </dbReference>
    <dbReference type="OMA" id="EFIDREW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8632" checksum="D3B5326C853A8673" modified="2017-01-18" version="1">MTANPFDNDAGEFHVLVNEEGQHSLWPAFAAVPAGWQSVFGPGSRGSALEYVETSWTDIRPRSVGSPERSGTVTAEGAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N904</accession>
    <name>A0A1E7N904_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isorenieratene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556637.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6209"/>
    <dbReference type="EnsemblBacteria" id="ARF81564">
        <property type="protein sequence ID" value="ARF81564"/>
        <property type="gene ID" value="B6264_24015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37171">
        <property type="protein sequence ID" value="OEV37171"/>
        <property type="gene ID" value="HS99_0004975"/>
    </dbReference>
    <dbReference type="OMA" id="HGFHGFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="518" mass="56221" checksum="97BB02E08CD08BF9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B3</accession>
    <name>A0A1E7N9B3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555139.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37281">
        <property type="protein sequence ID" value="OEV37281"/>
        <property type="gene ID" value="HS99_0005665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11648" checksum="7AFAE5F27B880749" modified="2017-01-18" version="1">MAELIEQGVARVAEKITATAPQGWAEAVQVSTQGPYGLGISTRYTVPGAKPQATSATQSIQLAGTFQDLEEVTAAVGATRGWERTRLEIRCRPSGEFDGGWCHRARSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9I0</accession>
    <name>A0A1E7N9I0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555705.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81600">
        <property type="protein sequence ID" value="ARF81600"/>
        <property type="gene ID" value="B6264_24235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37133">
        <property type="protein sequence ID" value="OEV37133"/>
        <property type="gene ID" value="HS99_0004760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8825" checksum="205717FAB19B68D0" modified="2017-01-18" version="1">MPVLPIEKIFTTLYRTLADSTADDAADQAADHAPTGSPTIPPAGHRPGHPRHVQRFEVGEAGLDALLQGVGVLTVFGLDGEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K9</accession>
    <name>A0A1E7N9K9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556396.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5409"/>
    <dbReference type="EnsemblBacteria" id="ARF82491">
        <property type="protein sequence ID" value="ARF82491"/>
        <property type="gene ID" value="B6264_29720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37377">
        <property type="protein sequence ID" value="OEV37377"/>
        <property type="gene ID" value="HS99_0006245"/>
    </dbReference>
    <dbReference type="OMA" id="AHNMICA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="464" mass="49995" checksum="9250D2E70E384B46" modified="2017-01-18" version="1">MSADADVEVLRREGRIVVVGASLAGLRAAETLRDKGFTGSLTMIGDEPYEPYDRPPLSKQALLGRARAEDTALPRRREIDAEWRLGVAAEGLDRQAKRVRLANRDTVPYDRLLITTGTRARPWIHPDEAALDGVFVLRTRDDSVRLDRKLAGSPSRVLVIGAGFTGSEVASACRERGLEVTVAERGPAPLVGALGGVIGAVADRLQRRKGVNLRCGISVTALEGDYAGRLRRAHLSDGSAIEAEVAVVSLGAIRNTDWLAGSGLAAGPRGIACDAGCRVFDVNGIVTDDIYAAGDVARSPHPLFDYQFLSLEHWGNAVEQAEIAAHNMICAGPDRRPHLWLPMFWSSQFGVNIKSVGVPSLGDQLVVAQGTLAEERFVAVYGYHGRVIAAASFDGAKWLGFYQQQIEAAAPFPPEYGTVDRRTETLEPVDPAFPDPHLPTHGPTVTLTGHSPSERRVEFVPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R7</accession>
    <name>A0A1E7N9R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucoamylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0004950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556644.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6214"/>
    <dbReference type="EnsemblBacteria" id="ARF83036">
        <property type="protein sequence ID" value="ARF83036"/>
        <property type="gene ID" value="B6264_24040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37429">
        <property type="protein sequence ID" value="OEV37429"/>
        <property type="gene ID" value="HS99_0004950"/>
    </dbReference>
    <dbReference type="OMA" id="GEPLQIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="229"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="605" mass="67582" checksum="03FABE8644C5A442" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA98</accession>
    <name>A0A1E7NA98_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formyltetrahydrofolate deformylase</fullName>
            <ecNumber evidence="1">3.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formyl-FH(4) hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purU</name>
        <name evidence="2" type="ORF">HS99_0026175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="EC" id="3.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.10" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287167.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000204.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7978"/>
    <dbReference type="EnsemblBacteria" id="ARF82719">
        <property type="protein sequence ID" value="ARF82719"/>
        <property type="gene ID" value="B6264_09180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37588">
        <property type="protein sequence ID" value="OEV37588"/>
        <property type="gene ID" value="HS99_0026175"/>
    </dbReference>
    <dbReference type="OMA" id="HADHHTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="32231" checksum="A717BCDA3C2E45BE" modified="2017-01-18" version="1">MPPVEQQPASAQYVLTLSCPDKQGIVHAVSSYLFMTGCNIIDSQQFGDGETGLFFMRVHFSAPEPVTADKLRASFAAIGASFGMDWQIHPTEQRMRIVLMVSKFGHCLNDLLYRTRIGALPVDIAAVVSNHTDLRDLTESYGVPFHHIPVTRDTKAEAERQLLDLVEKEDVELVVLARYMQVLSDQLCTALSGRVINIHHSFLPSFKGAKPYHQAHARGVKLIGATAHYVTADLDEGPIIEQEVARVTHDVSPDQLVALGRDVECQALARAVKWHSEHRVLLDGSRTVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAN4</accession>
    <name>A0A1E7NAN4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553969.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1701"/>
    <dbReference type="EnsemblBacteria" id="ARF82831">
        <property type="protein sequence ID" value="ARF82831"/>
        <property type="gene ID" value="B6264_14255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37742">
        <property type="protein sequence ID" value="OEV37742"/>
        <property type="gene ID" value="HS99_0025465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="19157" checksum="B87CACCCB5C603B4" modified="2017-01-18" version="1">MSRKVHPHNRADPEAKRSCGPADLDKLLTQARGAMTWLREGASVPQQQTVRDFAKSRAKALAVEGFRPTFLGRTTMARKAADAAIGATKAALVEQARKHGRTVYLVNPAHTTMDCAHCGVRAKHRLPLSERIYTCTACGVSSPRDKNSARVMLVRAGLNPVGVDRGRPQRPPDVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAP6</accession>
    <name>A0A1E7NAP6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="9" type="ORF">HS99_0024490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290148.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3444"/>
    <dbReference type="EnsemblBacteria" id="ARF78108">
        <property type="protein sequence ID" value="ARF78108"/>
        <property type="gene ID" value="B6264_03520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37759">
        <property type="protein sequence ID" value="OEV37759"/>
        <property type="gene ID" value="HS99_0024490"/>
    </dbReference>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="24409" checksum="44154DFFB04FFE14" modified="2017-01-18" version="1">MDTADRAHAPVVVAIDGPSGSGKSTVSRAVAARLGLSFLDTGAMYRAMTWWMLANDVDVTDAEAVAVACGKPVIVSGTDADGPTITVDGQDVSGPIRGPEVTAQVSAVAAVPAVRARLVELQRGCAEVAERGIVAEGRDMGTVVFPQATVKVFLTASEAARAERRAAELRAKGVDEATIVAMAADLARRDAADSSRETAPLAQAADAVLVDTSELTLEQVIDRIAALVEERAGLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBC3</accession>
    <name>A0A1E7NBC3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0024345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552033.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000265.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2011"/>
    <dbReference type="EnsemblBacteria" id="ARF79547">
        <property type="protein sequence ID" value="ARF79547"/>
        <property type="gene ID" value="B6264_12025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37991">
        <property type="protein sequence ID" value="OEV37991"/>
        <property type="gene ID" value="HS99_0024345"/>
    </dbReference>
    <dbReference type="OMA" id="PSFAWCS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV37991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="43250" checksum="E27468E390E335B1" modified="2017-01-18" version="1">MQHTRPSGGPPLGGRDAGNPDAGRLALLLDFAFLLLLAAALSRYLTHHADSPWIPWVIGLSTALAVAQPTASWLEHRRPAAPDRPRRWPVALVVALWVVLVLLAPSFAWCAVPLIYTGLRALPAKAAIPLVAALTLLVVIAEIRLPGTADATLVLLPPAVAALATGVFLFMARQAARQRALIADLVRTRRKLAATERREGTLAERERLAMEIHDTLAQGLSSQQMLLQAADRTWDTDPATARTHVRTAAEVAARNLAEARRFVRDLAPAELADGGTLDGALRALAGRESAESGLPVRFHLDGTPVPLPTAVQSALLRIAQGALANVREHAGASAAAITLSFLGDQAVLDIADDGQGFDPSAGDRRASGGARGYGLPAMRARLRQLGGTLTVESTPGEGTVVSAAIPLEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBG2</accession>
    <name>A0A1E7NBG2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1994"/>
    <dbReference type="EnsemblBacteria" id="OEV38029">
        <property type="protein sequence ID" value="OEV38029"/>
        <property type="gene ID" value="HS99_0024430"/>
    </dbReference>
    <dbReference type="OMA" id="AFEIIVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="47857" checksum="03FF7BB6AC78FC5D" modified="2017-01-18" version="1">MLDHRVEAPLVLDTEPPRTLRFRDHFALWMNLGVSLIGFSTAATVLGEKGSELSLAAAVTAIVAGTAVGTAMLGVAALIGARTGAPAMANLRGLFGTRLSYLPTVLNIVQCIGWGVFELLTIAAGAQTVAHTTGYRWLFVLLAGVLTTALTIWPLGSIAVLRRFVAGAVAVAMVYFTVQLGRQGVPDPGAGNWHGFLGATDAMIAVSISFVPMAADYTRHSRTPRSSFWGSFSGYTVAQVWCYVLGLMALLQSDGDPSRIFDSFLGVWAGWLFLLVLVLRETDQSFANVYSTAMSLQNLLPRVDRRVLSGGIGVLTTVLALRIDRFTDTYSNFLGLIGSVFVPLLAVLAVDYFFGAGRHGWDLSERAPSRWLMLLPWVLGFAVYQFIAPTAVAGWWVDFWTSAQEALHFTPQEWTSASLFAFLVPALATWALTPLTRRTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBH6</accession>
    <name>A0A1E7NBH6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction endonuclease subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551655.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000757.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8150"/>
    <dbReference type="REBASE" id="196223">
        <property type="entry name" value="M.SauDM1ORF13300P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79749">
        <property type="protein sequence ID" value="ARF79749"/>
        <property type="gene ID" value="B6264_13300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38041">
        <property type="protein sequence ID" value="OEV38041"/>
        <property type="gene ID" value="HS99_0022805"/>
    </dbReference>
    <dbReference type="OMA" id="NERSWGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="673" mass="71865" checksum="D1F13D2727C9F6E1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM0</accession>
    <name>A0A1E7NBM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555020.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000143.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3004"/>
    <dbReference type="EnsemblBacteria" id="ARF79700">
        <property type="protein sequence ID" value="ARF79700"/>
        <property type="gene ID" value="B6264_13000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38090">
        <property type="protein sequence ID" value="OEV38090"/>
        <property type="gene ID" value="HS99_0023100"/>
    </dbReference>
    <dbReference type="OMA" id="RMAAHRG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27729" checksum="40A36C391C4042D1" modified="2017-01-18" version="1">MMWRVQSAESPGAGTGSPLGRSGPVPPPGRGPVPTDLTEAVRAAQDGDEQAFRLLFRTVQPGLLRYLRVLVGGRPEDVQDAEDIASETWLQIARDLRGFSGDGDGFRGWAATIARNRAMDHLRARRRRPVTDLPFEYLVELAAGDDTARAALTTVGTADALALISRLPRDQAEAVLLRVVMELDAESAAQVLGKRAGTVRMAAHRGLRRLAKLLEQPFASGVGIPAAGKPAEEAAGKPAKKSSPQGVTERRAATLKDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC65</accession>
    <name>A0A1E7NC65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737812.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4198"/>
    <dbReference type="EnsemblBacteria" id="ARF80201">
        <property type="protein sequence ID" value="ARF80201"/>
        <property type="gene ID" value="B6264_15910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38282">
        <property type="protein sequence ID" value="OEV38282"/>
        <property type="gene ID" value="HS99_0022360"/>
    </dbReference>
    <dbReference type="OMA" id="ARLWDSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="39238" checksum="7CCDDC4155774154" modified="2017-01-18" version="1">MPRQLHLSAAIDAAADAATDSPRHLDPGHYAALARLAERAGLDFVTLDDSFTAEPSRPDALATLARIAPLTSRIGLVPTVTTTHTEPFHTSISLNTLDWVSGGRAGWLVGVSTTEAEAKAFGRRPVAPEDELWAEAADAAEVAARLWDSWEDDAEIRDTATGRFIDRDKLHYIDFEGRHFSVRGPSITPRPPQGRPVVAVPVAAGDLARDASPGGRARVATAIRYADVVLLDAPDRAARLTAATELRLRSGEHLRILARLDSALPDRAAEQRLLAELTATGTGVDGFHLVPAEPERDLAALAERIAPALRDAGLLRTGYPGRTLRDHLGLPRPASRYAGAGNATATATATATATATARPTTATALAEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE7</accession>
    <name>A0A1E7NCE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0022350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553293.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4200"/>
    <dbReference type="EnsemblBacteria" id="OEV38355">
        <property type="protein sequence ID" value="OEV38355"/>
        <property type="gene ID" value="HS99_0022350"/>
    </dbReference>
    <dbReference type="OMA" id="TYQNPGV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="15"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="45889" checksum="1CCABA156612BC90" modified="2017-01-18" version="1">MSSAGATAPQTTWWHTFYGGLQKMGRSLQLPVAVLPAAGILNRLGQPDVFGKDGLGWTDVAKVFAAAGGALLDSALGLPMLFCIGVAIGMARKADGSTALAAVVGFLVYYKVLHAFPENCKPPTVLVSDQCVDYSSAKAAGATYQNPGVLGGILIGLMSAWLWVRFHRTKLVDWLGFFNGRRLVPMITALVGMLTAVVALWVWPPIGRGLNDFSQDLADLGAGGAGIFGVFNRALLLIGMHQLLNTFVWFQFGEFTKADGTIVHGDIPRFLAGDPTAGQFQSGFFPIMMFALPAAALAIAHSAKPHRRKEIYGLMLSVGLTSFVTGVTEPIEYSFAYVAPALYGVHALLTGASMAVTWGLGVHDGFSFSAGLIDYVINWGLATKPWLIIVIGLGFAAVYYGLFRFIIVKFDLKTPGREDETEVEDVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ5</accession>
    <name>A0A1E7NCJ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene277"/>
    <dbReference type="EnsemblBacteria" id="ARF82199">
        <property type="protein sequence ID" value="ARF82199"/>
        <property type="gene ID" value="B6264_27950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38411">
        <property type="protein sequence ID" value="OEV38411"/>
        <property type="gene ID" value="HS99_0021105"/>
    </dbReference>
    <dbReference type="OMA" id="PAAEWCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13033" checksum="2B17D963E5C6F5CE" modified="2017-01-18" version="1">MKFLISLHINPAVLDALTDDEKAAIGAGHGKFIEALKSSGELIVTQALVDPSQAAVVTVRDGQPAVTDGPFLEAKEFLGGFYLVDCEDKERAIELAAQIPDAAIEGLGVEVRQVMFSDGHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCS0</accession>
    <name>A0A1E7NCS0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288423.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3070"/>
    <dbReference type="EnsemblBacteria" id="ARF82122">
        <property type="protein sequence ID" value="ARF82122"/>
        <property type="gene ID" value="B6264_27500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38482">
        <property type="protein sequence ID" value="OEV38482"/>
        <property type="gene ID" value="HS99_0021545"/>
    </dbReference>
    <dbReference type="OMA" id="PERACRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="30541" checksum="99A10FDA01631FC2" modified="2017-01-18" version="1">MLGVLGDLVEDIVVWADGPLRHGTDSGARVFRRRGGSAANVACFAAGQYPVRFLGCVGADPVGDGVVAELGGHGVDVRVQRHGRTGSIVVLIDPDGERTMLPDRGAAKLLERAPDEWLAGLTHLHVPAYSFDGEPVGRTAVDALARVRQAGGTTSVDASSTGMLEQFGRERFLALLVGLAPTFVFANRSESAFLGLLVDGLPGPERARLGATTVVTKSGAEPTTVDVPGEDLFTVPVPPVAEVRDLTGAGDAFAAGFLAGFLRNGDLRLAAGLGHRSAARVLGSPGASLGGGGGGCGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ7</accession>
    <name>A0A1E7NCZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281266.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000654.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene661"/>
    <dbReference type="EnsemblBacteria" id="ARF77602">
        <property type="protein sequence ID" value="ARF77602"/>
        <property type="gene ID" value="B6264_00495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38576">
        <property type="protein sequence ID" value="OEV38576"/>
        <property type="gene ID" value="HS99_0020080"/>
    </dbReference>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="31282" checksum="9000168E7EDBF109" modified="2017-01-18" version="1">MSNIPSVTLNDGTQIPQLGFGVWQVPDAEATPAVRTAIEAGYRSIDTAAIYENETGTGAAINEALAGGLAREDLYVTTKLWNSGTRDWSGEQGRDAVLREFDASLDKLGLEYIDLYLIHWPRPMHGTFLNVWKALEQLKEGGRVKSIGVSNFGTEQLTRLLDEASVVPALNQVELHPYFPQGELRAFHAQHGIATEAWSPLGQGGELLAEPELARIAEKHGRTVAQVVLRWHLQNGVIAIPKSVTPSRIRENLAVTGFELDTEDLAAIAGVATGKRIGPDPQGFDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCZ8</accession>
    <name>A0A1E7NCZ8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0019975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281310.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000323.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene682"/>
    <dbReference type="EnsemblBacteria" id="ARF77585">
        <property type="protein sequence ID" value="ARF77585"/>
        <property type="gene ID" value="B6264_00390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38562">
        <property type="protein sequence ID" value="OEV38562"/>
        <property type="gene ID" value="HS99_0019975"/>
    </dbReference>
    <dbReference type="OMA" id="DQDAFQM"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="184"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="37595" checksum="C215D6FEE3B52BCB" modified="2017-01-18" version="1">MPSEATTVRREPLDPSGAGAAIQRWTLTAGPYEASVLTLGATLHTLSGPDRSGRTAQLLLSTDELAQILGPARHYGTVVGRYANRIDGSSVTIDGQNHPLAPTGGGMTIHGGPDGFAQRMWAAEPVEGGVLLRLHSPDGDQGFPGALDVTVSYTLSYAPGAGGELVIDYRAVTNKPTVVNLTNHAYFNLAGEGSGDVLGHLLTLDADEYTPADERQIPYGRTEPVAGTPFDFTVATPIGKSLHDDHPQLAGPGGYDHNWALRARPASGGPARAALLEDPVSGRTLEVLTTEPGLQVYTANKFQGAVTGASGVPYGPFAGIALETQHFPDSPHHPAFPSTELRPEEEFRSTTVLRLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND88</accession>
    <name>A0A1E7ND88_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033351831.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000847.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1782"/>
    <dbReference type="EnsemblBacteria" id="ARF77695">
        <property type="protein sequence ID" value="ARF77695"/>
        <property type="gene ID" value="B6264_01060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38662">
        <property type="protein sequence ID" value="OEV38662"/>
        <property type="gene ID" value="HS99_0020645"/>
    </dbReference>
    <dbReference type="OMA" id="HEGSTEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016516">
        <property type="entry name" value="UCP07580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39456">
        <property type="entry name" value="PTHR39456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10118">
        <property type="entry name" value="Metal_hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007580">
        <property type="entry name" value="UCP07580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="34231" checksum="37E40105CD8E826A" modified="2017-01-18" version="1">MPRSTPVPALAAPAARVHESLVLEPRDVRFDWARLPLHWIPDEPMATHVINVLHLLLPEGERWFVKVFKEALPLIRDEQLREEVLGFIGQEAIHAEAHQEVLDHLLGQGLDPRPYVRQVSWLFQRVLGDKPGLTPAQRRENVIERVAFVAAIEHFTAFLGNWALNSPGLDRAKADPTMLDLLRWHGAEEVEHRSVAFDLMVHLDPGYLRRVRGMALSGPLLVHLWVRGARFLLAADPTLQGRLKPSWREAGRIARRGLLPDPIRSIRSGLRYLRPGYHPTQEGSSSQALGYLATSPAARAAAAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDB5</accession>
    <name>A0A1E7NDB5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000380.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1792"/>
    <dbReference type="EnsemblBacteria" id="OEV38671">
        <property type="protein sequence ID" value="OEV38671"/>
        <property type="gene ID" value="HS99_0020695"/>
    </dbReference>
    <dbReference type="OMA" id="QEKFGHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017595">
        <property type="entry name" value="OHCU_decarboxylase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="SSF158694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03180">
        <property type="entry name" value="UraD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OHCU_decarbox" evidence="2">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="17595" checksum="7BD96B5267F5C6CC" modified="2017-01-18" version="1">MTNHPHALDALAAADAAELEGILLEVCSSPRWAAAVAEAKPWSSREALLAANAAAMAGLTAADLRDAMAGHARIGQPKAGDATSEREQAGIQGVDQAVLDELHEANAAYEAKFGHVFLICATGRTAATMLAALRERHPNDPATEAEIVRGELRKINDIRLNRLLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDK8</accession>
    <name>A0A1E7NDK8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="8" type="ORF">HS99_0019185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553695.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7389"/>
    <dbReference type="EnsemblBacteria" id="ARF81203">
        <property type="protein sequence ID" value="ARF81203"/>
        <property type="gene ID" value="B6264_21920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38796">
        <property type="protein sequence ID" value="OEV38796"/>
        <property type="gene ID" value="HS99_0019185"/>
    </dbReference>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="28147" checksum="09139F5B3C940A36" modified="2017-01-18" version="1">MTLAPFGARLRQALDTRGQLCVGIDPHASLLSAWGLGDDLAGLETFSRTVVEALADRVAVLKPQAAFFERFGSKGVAVLEKSVEEARAAGALVLMDAKRGDIGSTMAAYAEAFLSPAGPLFSDAVTVSPYLGFGSLRPALDLAREQGCGVFALALTSNPEGAEVQRAVGADGEPVAASVLRQLAAENAGAAPLGSFGAVVGATLADAGVDLAINGPLLAPGIGAQGATMADLPRVFGASVINVVPSVSRDVLRHGPSVPALREAAERFVGEFAEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX1</accession>
    <name>A0A1E7NDX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0019735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555455.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6526"/>
    <dbReference type="EnsemblBacteria" id="ARF81297">
        <property type="protein sequence ID" value="ARF81297"/>
        <property type="gene ID" value="B6264_22470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38889">
        <property type="protein sequence ID" value="OEV38889"/>
        <property type="gene ID" value="HS99_0019735"/>
    </dbReference>
    <dbReference type="OMA" id="MGKDAWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="41791" checksum="E6B0151BB09A3425" modified="2017-01-18" version="1">MHAILHALSIAGSMTWEITWALILGFLLSAVVQAVVHKSTVVRLLGDDRPRTLAVASALGAASSSCSYAAVALARSLFRKGANFTAAMAFEIASTNLVVELGVILALLLGWQFTAAEFVGGPVMILLLALLFRSLLRDRLLQEAREQAEFGRAGSMEGHAAMDMSVAGPGSFARRLLSRQGVTSVSHVFVMEWAAILKDLVIGLLIAGAIAAWVPDSFWQAFFFVDHPLAAKLWGPLVGPLVAIASFVCSIGNVPLAVVLWKGGISFGGVVAFIFADLLILPILNIYRKYYGTRMALFLLGTFYAAMVAAGYVVEFVFGGLGLVPNQREAEIPMAGVEWNYTTWLNIAFLLLALGLVVRFFRTGGAAMLRMMGGAPDADEHAGHEHQGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE97</accession>
    <name>A0A1E7NE97_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557525.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1031"/>
    <dbReference type="EnsemblBacteria" id="ARF83267">
        <property type="protein sequence ID" value="ARF83267"/>
        <property type="gene ID" value="B6264_30480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39036">
        <property type="protein sequence ID" value="OEV39036"/>
        <property type="gene ID" value="HS99_0018210"/>
    </dbReference>
    <dbReference type="OMA" id="HWYWRPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21648" checksum="DF923B2D93CC0048" modified="2017-01-18" version="1">MADHWWWRPGWAPGTRWYTWHLVFDGADDVHRLAADYRHALAEVPGLTLVPDRWLHLTMQGLGSTAEVSETAARAIADAAAHHLAKIPPFDLALGPAIVTPEALLLTVDPAEPVHAVRSAIRVAIADVWPKVPESADGFRPHVSVAYSSADGPARPAADALAHVTTYPATARIAAAELIILNRDRQMYEWETAARVPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED0</accession>
    <name>A0A1E7NED0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0018360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene998"/>
    <dbReference type="EnsemblBacteria" id="ARF83294">
        <property type="protein sequence ID" value="ARF83294"/>
        <property type="gene ID" value="B6264_30645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39061">
        <property type="protein sequence ID" value="OEV39061"/>
        <property type="gene ID" value="HS99_0018360"/>
    </dbReference>
    <dbReference type="OMA" id="RWAYETK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="34053" checksum="F8AF72C34B60F4D6" modified="2017-01-18" version="1">MSPRGSAQVTLPHVEPMLATAGPLPAGPGWMGEVKWDGVRCVAYVPEAAPVRLLGRHGTDLTDRFPEVVEALTMRGPLVLDGELVVMRGGRPSFAALQGRVHRTRPAAVRTGAAATPAVFVAFDLPHTGERSLLIEPYARRRQLLEGLELERPGLRVPPAWDSITEAFGWTREHGLEGVVAKRSDSPYRPGTRSRDWIKIKHLRTADVVIGGWLPAPREASVRAVLVGVPVEAEGRLTFVGSVGTGFAGAERRALAAVLRRIDSPVSPFTAAGLGLPRGTLVRFVRPELRAEVEFLELTDAGRLRQPVWRGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV0</accession>
    <name>A0A1E7NEV0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557392.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4383"/>
    <dbReference type="EnsemblBacteria" id="ARF83243">
        <property type="protein sequence ID" value="ARF83243"/>
        <property type="gene ID" value="B6264_30350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39013">
        <property type="protein sequence ID" value="OEV39013"/>
        <property type="gene ID" value="HS99_0018080"/>
    </dbReference>
    <dbReference type="OMA" id="WHHGWET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="16610" checksum="C669DC422F716EAB" modified="2017-01-18" version="1">MKTTPNAPAARFAAAYALLRAGADVGDHLVQSDHCARTKGATDAAPVTGDDGTVHGTAAGRKACAVHCLTYSATQATAVLLGARALGMRLRPGQVAAALAISGLTHYAIDRRVPGGLLQRFADAIGKGNFYRLADHGMNGAYCMDGAVHHAFETVAAAVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF53</accession>
    <name>A0A1E7NF53_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6458 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284846.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000731.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3677"/>
    <dbReference type="EnsemblBacteria" id="OEV39330">
        <property type="protein sequence ID" value="OEV39330"/>
        <property type="gene ID" value="HS99_0001040"/>
    </dbReference>
    <dbReference type="OMA" id="FATDWHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045597">
        <property type="entry name" value="DUF6458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20059">
        <property type="entry name" value="DUF6458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6458" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="8237" checksum="B5DC5FB63DDC0F88" modified="2017-01-18" version="1">MGIGGCIVLFALGAIMAFATDWHVNGVNLHLVGWILMAAGLLGLITYVNVFRRRRLVRSVESDEPVEERRYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE5</accession>
    <name>A0A1E7NFE5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">HS99_0001180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288886.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000596.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39355">
        <property type="protein sequence ID" value="OEV39355"/>
        <property type="gene ID" value="HS99_0001180"/>
    </dbReference>
    <dbReference type="OMA" id="AKAKTMC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="11005" checksum="FF4F74FCB68D8A6D" modified="2017-01-18" version="1">MADISRLPGAYDHYWEWQLEAACRRVENSLFFHPAGERGAAHKAREEAAKAVCARCPVQMECRRHALETREPYGVWGGLSEEERSLLLSPAHRRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG9</accession>
    <name>A0A1E7NFG9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation_ATPase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3125"/>
    <dbReference type="EnsemblBacteria" id="OEV39451">
        <property type="protein sequence ID" value="OEV39451"/>
        <property type="gene ID" value="HS99_0001760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8806" checksum="D1F7FAC255191560" modified="2017-01-18" version="1">MLFVALLAAQLGVVLGLRERLLTRANPFLPVAVLASAALGAAALYLPFLRDVLETVPLSWGDHAAPAVAGLLGFTTARLRKQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFI1</accession>
    <name>A0A1E7NFI1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1775 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0001445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556056.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000615.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1578"/>
    <dbReference type="EnsemblBacteria" id="OEV39395">
        <property type="protein sequence ID" value="OEV39395"/>
        <property type="gene ID" value="HS99_0001445"/>
    </dbReference>
    <dbReference type="OMA" id="TVVKWDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="3">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="24217" checksum="77EB3854FF2E53C8" modified="2017-01-18" version="1">MGATTVLGAAVPASAHVIVQPSSVPKNATDQTFAFRVPNEDDKNSKVKVEIDFPTDHPIPSVKVAPVPGWTDSIRTTKLATPVHTDDGDITDAVSQVVWTGGQITPGHFQDFTVDLGALPGGTDKVVFKALQTSGDGTVVRWIEEPPAGQPEPKNPAPVLKLTAATAGDSDAPAPGAAAGAKADPTPANTTSTDTAKASGSDSTARALGVAGIVVGVLGTAAGFVLGRRGRGRGTGADASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFP2</accession>
    <name>A0A1E7NFP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556235.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5054"/>
    <dbReference type="EnsemblBacteria" id="OEV39507">
        <property type="protein sequence ID" value="OEV39507"/>
        <property type="gene ID" value="HS99_0002105"/>
    </dbReference>
    <dbReference type="OMA" id="TEGHINR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199098" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10643" checksum="B3738D0DB3C3C307" modified="2017-01-18" version="1">MTALAAATTGFAALLTPAPANADALTGWITQVRAADLPFLHAYVTGLERDRTAVDHALTLPWRNGRTEGVNNKIKLLKRQTYGRAGYRLLRQRILLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG62</accession>
    <name>A0A1E7NG62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556274.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5082"/>
    <dbReference type="EnsemblBacteria" id="OEV39483">
        <property type="protein sequence ID" value="OEV39483"/>
        <property type="gene ID" value="HS99_0001965"/>
    </dbReference>
    <dbReference type="OMA" id="SATHPYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="28728" checksum="2C3EBD34637DDF94" modified="2017-01-18" version="1">MTVLRVTDLTVHHPGPLGQVTAVDGVSLEVPSGTTLGLVGESGSGKSSLARAIVGLVPVHTGRIMLDGREIRARTIRDRRRLGRLVQVVLQDPDTALDPRMTVRQTLGEAATVFHRLDRPARDKRVTELLELVGLDPRLAGRLPRQLSGGQRQRVALARALAVEPGLLIADEVTSALDVSVQAAVLNTIRELQRRLGLSMLFIGHNLPAVCHVSDAVAVMRHGRIVETAPTDALLRAPQHPYTRTLLAAVPSLRTPPPAPAPEEQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGG4</accession>
    <name>A0A1E7NGG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3597"/>
    <dbReference type="EnsemblBacteria" id="OEV39801">
        <property type="protein sequence ID" value="OEV39801"/>
        <property type="gene ID" value="HS99_0000660"/>
    </dbReference>
    <dbReference type="OMA" id="FQYVSMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="46111" checksum="E043A1B9DB72D4F7" modified="2017-01-18" version="1">MVGGSLGNLVEWYDWFVYASFAVYFADDFFPGSDSTAKLMNTAGIFAVGFLMRPVGGWLLGRAADRHGRKSALTLTVTMMSAAAVLIAVAPTYARAGYLGAGVLLLARLLQGMSIGGEYAASATYLTEASAPNRRGLGSSFQYVSMTCGQLLGLGILIVMQHTLSSAQLHSWGWRVPFLLGAVLAGVVLWLRRRLPETEAFTADARTAEAGGRKQDGARGTLRSLWEHRRQALLVMALTLGGTVAYYTYTTYLTKYLIGSAGLAKNTATLVSFTALALFAAIQPLAGLLSDRIGRRPLLITFALGCTVGTYPLMTALGSASGYWSALGLSLVALVIVTGYTSINAAVKAELFPTRIRALGVALPYALANALFGGTAEYIALWFKNSGHESGFFWYVSGCALVSLVVYVLMPDTRNAVLSPEEARTEAAAAGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGN9</accession>
    <name>A0A1E7NGN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550341.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000789.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2771"/>
    <dbReference type="EnsemblBacteria" id="OEV39633">
        <property type="protein sequence ID" value="OEV39633"/>
        <property type="gene ID" value="HS99_0002885"/>
    </dbReference>
    <dbReference type="OMA" id="AKREIYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="264"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="515" mass="56380" checksum="7DAD7C74531AC6B3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGQ7</accession>
    <name>A0A1E7NGQ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385614.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2816"/>
    <dbReference type="EnsemblBacteria" id="OEV39862">
        <property type="protein sequence ID" value="OEV39862"/>
        <property type="gene ID" value="HS99_0003105"/>
    </dbReference>
    <dbReference type="OMA" id="ARWVGPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="38642" checksum="0DA5FD0D81F0EDAC" modified="2017-01-18" version="1">MHDGVRPAGAVQEEPVTRAATLAEIAQEAGVSAPTVSKVLNGRADVAPATRERVEELLQRYGYRRRRGNRRASPLLELVFHELESAWAVEVIRGVENAVREEGLSIVLSESAERHGPGQSWVDGVLARRPTGVVLVLSDLDRSLREQLSRRDVPFVVLDPAGDPGQDVPAVGTTNWDGGLAATRHLLDLGHRRIGLIGGPARMMCSRARADGYRAALDMAGIPYDADLVREGSFHHESGRLLGLELLGLPERPTAVFAGNDLQALGLYEAARELGLRVPEDLSVVGFDDLPLARWVGPPLTTVRQPLTEMAEVATRLVIDLARGVRPGTLRVDLATSLVQRSSTAPPRTAVPGQVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGX5</accession>
    <name>A0A1E7NGX5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pqqC</name>
        <name evidence="4" type="ORF">HS99_0003365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550448.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000628.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2866"/>
    <dbReference type="EnsemblBacteria" id="OEV39713">
        <property type="protein sequence ID" value="OEV39713"/>
        <property type="gene ID" value="HS99_0003365"/>
    </dbReference>
    <dbReference type="OMA" id="AYVHFVR"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="16"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="26741" checksum="0F674166AA360938" modified="2017-01-18" version="1">MTSPARTPAQFTADLHAYAEKYWHHHPFHLRLHEGELTADQLRLWIANRWYYQARLPQKDAAVIANCPVAEVRRRWTERIVYQDGAADGQGGHEEWLRLAEAAGLERTAVLDGSLLLPGVRFATDAYVDFARTRPWTESVAASLTELFSPDLMRRRLDAIKTHYTWIAPSGHGYFTDRPPVAAADAEHALGLVIAHCATRAEQDAALAALSFKCDVLWSMLDAIEHASEGTTESGPENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>S4S398</accession>
    <name>S4S398_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CtcD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ctcD</name>
        <name evidence="2" type="ORF">HS99_0013365</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2013" name="Metab. Eng." volume="19" first="69" last="78">
            <title>Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Cheng X."/>
                <person name="Liu Y."/>
                <person name="Deng Z."/>
                <person name="You D."/>
            </authorList>
            <dbReference type="PubMed" id="23800859"/>
            <dbReference type="DOI" id="10.1016/j.ymben.2013.06.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">F3</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM627755">
        <property type="protein sequence ID" value="AEI98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282616.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5221"/>
    <dbReference type="EnsemblBacteria" id="ARF80643">
        <property type="protein sequence ID" value="ARF80643"/>
        <property type="gene ID" value="B6264_18585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33540">
        <property type="protein sequence ID" value="OEV33540"/>
        <property type="gene ID" value="HS99_0013365"/>
    </dbReference>
    <dbReference type="OMA" id="YCQIEKL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AEI98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="27812" checksum="9C55EF9A27F95941" modified="2013-10-16" version="1">MRLIDLSSTIDANAWEVDGIRHEVLTPADGARHMAEGMLRDHGLEFDVADLPDGELLSLDTLTLTTHTGTHVDAPSHYGSRAAYGVPRHIDELPLEWFIGPGVRLDLTDCGVGTVGVDRLRRAFDEIDHRPSAGEIVLLHTGAERLAGTPEYFTRFAGLDGAATNLLLDLGVRLIGTDAFGLDAPFTHMLAEFQRTRDRSVLWPAHFAGRQREYCQIERLSNLGALPAPTGFTVQAFPVKIAGAGAGWTRAVALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV79</accession>
    <name>A0A1E7MV79_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553807.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6930"/>
    <dbReference type="EnsemblBacteria" id="OEV32342">
        <property type="protein sequence ID" value="OEV32342"/>
        <property type="gene ID" value="HS99_0016710"/>
    </dbReference>
    <dbReference type="OMA" id="YAWMREF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20215" checksum="FE67235CBBCD3C04" modified="2017-01-18" version="1">MTHTTKVLAIVTNYGVEQDELLVPVRHLRENGTQVDIAAPDRDDIRTLVNDKDPGEIVRPTHTLGEIEPSGYDLLLIPGGTINADTLRLRQEAVALVLAFTTSGRPVAAICHGPWMLAEAGVAYGKRLTSYPSLRTDLANAGATWADESLVTDDANGWRLITSRNPGDLDDFLRGIDSALSARTGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVJ7</accession>
    <name>A0A1E7MVJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1204"/>
    <dbReference type="EnsemblBacteria" id="OEV32456">
        <property type="protein sequence ID" value="OEV32456"/>
        <property type="gene ID" value="HS99_0017395"/>
    </dbReference>
    <dbReference type="OMA" id="AMICSAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24404" checksum="7358C205ACC7F353" modified="2017-01-18" version="1">MAAALVGVVIGVGIIKTRYDDPAPAAAAGPTGAPAPTATPTPYGAKSNGSHFGSLRDLLLPVPAGFELGPDEGGYGNDTEIGAGQISDELDAELQQVPKDKRDKLRSYWEGLHVKGTGVRTYRNDGNNLVVGLRLRQFNQQEVQRINEYTAVFTGDTGIFRSGPQIPGHPEAHCYLMPAPPSAPIDYLECSAAEGDLLVVMSVEGVAPLPKDKIVGLFTLQLDRLASPGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR8</accession>
    <name>A0A1E7MVR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6976"/>
    <dbReference type="EnsemblBacteria" id="OEV32519">
        <property type="protein sequence ID" value="OEV32519"/>
        <property type="gene ID" value="HS99_0016930"/>
    </dbReference>
    <dbReference type="OMA" id="VEWEHVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="304" mass="32616" checksum="89A695548B685916" modified="2017-01-18" version="1">MAAVQRLAGGSKKGVYRLVTDDGATAVAYRWDDSENYWPAAEGDDDLADPFSPGLGLDLFEAAHARLAGLGVRVPAIRLVDREGAYGPADLAVVEDVPGESLASLLARDPLAATPVLARLGEALEAMRGHRAPAYGKVAVVDAGRASRGSSCEGVVLERALRDLAEAAARDSRMAGARERLEERLRALAGAVRPRAEYAVVHGELGPDHVLVDAGGQPVVIDLEGSMYFDVEWEHVFLRIRLHEAYPPLEAPGLDEDRLALYLLAQRLSLTAGPLRLLDGDFPDRAAMAGIAEYNLKRALELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW37</accession>
    <name>A0A1E7MW37_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0015355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3134"/>
    <dbReference type="EnsemblBacteria" id="OEV32646">
        <property type="protein sequence ID" value="OEV32646"/>
        <property type="gene ID" value="HS99_0015355"/>
    </dbReference>
    <dbReference type="OMA" id="TGAGWPF"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="346"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="717" mass="75965" checksum="F33DE2A63D13BA5E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA8</accession>
    <name>A0A1E7MWA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CopY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290208.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000754.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7846"/>
    <dbReference type="EnsemblBacteria" id="ARF78239">
        <property type="protein sequence ID" value="ARF78239"/>
        <property type="gene ID" value="B6264_04285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32722">
        <property type="protein sequence ID" value="OEV32722"/>
        <property type="gene ID" value="HS99_0015800"/>
    </dbReference>
    <dbReference type="OMA" id="HTELDRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13831" checksum="3FF0403B1C6F8E58" modified="2017-01-18" version="1">MSDVPSARRPAGELEAEVLAALWSARQPMTPQDVQTALGGHLARTTIATILARLHDKGTVERTRAGRAYAYIPTVQDTAGLAARRMHTELGREADRSTVLARFVSDLSAEDEQLLRELLGDGGPGSAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC2</accession>
    <name>A0A1E7MWC2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598934.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000836.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32709">
        <property type="protein sequence ID" value="OEV32709"/>
        <property type="gene ID" value="HS99_0015725"/>
    </dbReference>
    <dbReference type="OMA" id="VVRYTVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="43059" checksum="C8E1CD760959A2B5" modified="2017-01-18" version="1">MRHRMVRESGGRSQEPREWNAERSGPDGPGGQDRFAGQEEFSRRTLAAVDFPVYGVAGPTGRGEALAAFETCGGELRWVEVQVGDWTTAAGPYVTVRTYRPGADGCEVLPELEDVVEDERDRVYEQLGIDEGDGPGQVRALREWITVDGEYCAIEVHEDRPVASGGSGSAGQVWAGRLRVGGQAVTVCGRGLPPGRVELGGIGDFECYLRGRTELLRDLASRRARYVPVEERELPPAVGLEAHRELIAQSIAEAAAIEAQVRVGRTPRLPRGLRGDVCAERWETAVRQQMRLATETREEAAAAVTSMVNHLNRLSQQTHWLVGTPEGEAAVEEVVRYTVFASEVASLPAQRAWEQLWRERPGGGGEGAWEEQRLVEQLWLSAWEQWRAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWJ8</accession>
    <name>A0A1E7MWJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6098"/>
    <dbReference type="EnsemblBacteria" id="OEV32816">
        <property type="protein sequence ID" value="OEV32816"/>
        <property type="gene ID" value="HS99_0016105"/>
    </dbReference>
    <dbReference type="OMA" id="WAWAPVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16952">
        <property type="entry name" value="Gln-synt_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="117"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="47523" checksum="FA4C947E4D4D13E1" modified="2017-01-18" version="1">MSPRAERAARAQEAVDRLRTAAVEAVAVTWVDNAGITRVKAVPLSGLVHAAEWGVGTAPCFDVFLADDAITTSPVIGGPTGDLRLYPDLDRLVPLAAQPGWAWAPGDRHTQDGVPHPGCQRLFARRMEAAAAARGLSLKAGIEVEWVVALAGPPNEPPQYPTHGPAYGMHRLTDLSDYLRDVVRALGEQGLGVLQIHPEYAPGQFEVSVAPEGPVGAADTSVLVRQTVRAVSAKYGLRTSFAPVVEPDGVGNGGHLHLSLWRDGRNLGHGGSGPHGLTAEAEGFLAGVLQALPELLVLGCSSPAGYLRLVPSHWAGAYQCWGLENREAALRLVTGSTGERAATANAEVKCFDASANPYLAVGAVIAAGLAGLEQRHVLPPEFTGDPAAAEPGTVPRLPQGPAEAIAAYERSAVLRGALGEPLHQAVLAVRRAEAEQYADAGPEELVAATRWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM8</accession>
    <name>A0A1E7MWM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000083">
        <property type="protein sequence ID" value="OEV32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367158.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4117"/>
    <dbReference type="EnsemblBacteria" id="ARF82850">
        <property type="protein sequence ID" value="ARF82850"/>
        <property type="gene ID" value="B6264_15500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32840">
        <property type="protein sequence ID" value="OEV32840"/>
        <property type="gene ID" value="HS99_0039895"/>
    </dbReference>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="34519" checksum="65C16E912316BFDA" modified="2017-01-18" version="1">MTPGTAPATPATDPRAALTALRAEIGKAVVGQDAAVTGLVVALLCGGHVLLEGVPGVAKTLLVRTLSTALSLETKRIQFTPDLMPGDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQAALLEAMEERQVTVDGEPRALPVPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLILPLPDRDQEFQVLSRHASGFDPKDLAAAGVRPVAGPEHLAAAREQITGLTVSPEVLAYIVDLCRATRQSPSLSIGVSPRGATALLAASRAWAWLAGRDYVTPDDVKALALPTLRHRVALRAEAEMEGVTADSVIQAVLAQTPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX89</accession>
    <name>A0A1E7MX89_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5645"/>
    <dbReference type="EnsemblBacteria" id="ARF81465">
        <property type="protein sequence ID" value="ARF81465"/>
        <property type="gene ID" value="B6264_23405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33050">
        <property type="protein sequence ID" value="OEV33050"/>
        <property type="gene ID" value="HS99_0014375"/>
    </dbReference>
    <dbReference type="OMA" id="TARMFGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="12968" checksum="9A13FA6F67412C21" modified="2017-01-18" version="1">MTDAPDAEVIALAGKLFDAARAGDTATLTAAVDAGVSADLTSGSGDTLVMLAAYHGHAATVEALLQRGADPNRANDKGQTPLAGAVFKGSTDVVDALLADGADPRAGVPSAVDAAAMFGKTELLARFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXF8</accession>
    <name>A0A1E7MXF8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33094">
        <property type="protein sequence ID" value="OEV33094"/>
        <property type="gene ID" value="HS99_0014650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="9734" checksum="603F79C9B6902F6B" modified="2017-01-18" version="1">MPAESGQPPTAVKVREVPAAIEAREALLAAIAQEARTVVDKQPGQASSALVELAQAYNLLATTSVPVTTDGTSALTPVQSRAGGHQVGMCLELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY47</accession>
    <name>A0A1E7MY47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein DegV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283864.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000912.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7040"/>
    <dbReference type="EnsemblBacteria" id="ARF80432">
        <property type="protein sequence ID" value="ARF80432"/>
        <property type="gene ID" value="B6264_17320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33331">
        <property type="protein sequence ID" value="OEV33331"/>
        <property type="gene ID" value="HS99_0012090"/>
    </dbReference>
    <dbReference type="OMA" id="MALGFCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="29069" checksum="7DC5CA1423E6DA54" modified="2017-01-18" version="1">MPSDLALVTDSTAYLPQEALDRHGITVVPLSVAVGDSVLCEGVEISPKDVAEALRAKQRVTTSRPNPETFAAAYRAAAEAGATGIVSVHISGELSGTVEAARLAAAEAPVPVRVVDSRLVGMALGYGVLAAAEAIAAGRDLAEAAEAATRRAAGTSGFFYVDTLEHLRRGGRIGAARAMLGSALAVKPLLHLDGGRIEPLEKVRTASRAIARLEEIAVERSGEGEVDITVHHLAAEERAEPLAERLRARVPGLRDLYVGEVGAVIGAHVGPGLLAVVVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA3</accession>
    <name>A0A1E7MYA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3988"/>
    <dbReference type="EnsemblBacteria" id="ARF80503">
        <property type="protein sequence ID" value="ARF80503"/>
        <property type="gene ID" value="B6264_17730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33399">
        <property type="protein sequence ID" value="OEV33399"/>
        <property type="gene ID" value="HS99_0012505"/>
    </dbReference>
    <dbReference type="OMA" id="QQRFDCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="25639" checksum="C8AC5681FEC979F9" modified="2017-01-18" version="1">MAPRPVPPPRAAGATALAALLLASGTACGGGADASPNAEVAQQSPARDRIGTLSVHGPQGSRACTASVVHSPGHNLLVTAAHCVQNQRVGLLDGLVFTPGYRNGYSPYGSWEVESITVDPRWASDDDPDYDVAFVTVRPVDGRQVEDAVGGNPLGTGRGVGLAVSVTGYPNESDEPITCSVRTKSQSATQERFDCGGYTDGTSGSPWVTADGAVVGVIGGYQEGGETPGTSYSVAFDQRVSDLYRRATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA9</accession>
    <name>A0A1E7MYA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386995.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000607.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3961"/>
    <dbReference type="EnsemblBacteria" id="ARF80527">
        <property type="protein sequence ID" value="ARF80527"/>
        <property type="gene ID" value="B6264_17870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33422">
        <property type="protein sequence ID" value="OEV33422"/>
        <property type="gene ID" value="HS99_0012645"/>
    </dbReference>
    <dbReference type="OMA" id="VPVELHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="24880" checksum="E72D9B5832E6ED32" modified="2017-01-18" version="1">MAARTSHPVGTPEDLGRAPGLRERKKQQTRDALVQAAHALFLGQGFARTTVDEIASAVDVSQRTFFRYFANKDEVALAVMAEAEDYFIHCLRHRPAEEPPLQALRASIVKAWRDLGNARTSGPGSISSALELLRIIEETPALLAAHLRRVTEQERLVVQVLAEREGLDPARDLRPVVLAAVFGSLLRAAHLSWTAEQEPAGPEGMVAIIERYFDQLGPALAGHWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV1</accession>
    <name>A0A1E7MYV1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33606">
        <property type="protein sequence ID" value="OEV33606"/>
        <property type="gene ID" value="HS99_0013170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6695" checksum="84497EED525833AB" modified="2017-01-18" version="1">MRHRRSRAQAAAHHNRQVAGVTGVLLLVVSLYSVTIGPDGWLWFAWAVLLLACAALFAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD7</accession>
    <name>A0A1E7MZD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0012380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4011"/>
    <dbReference type="EnsemblBacteria" id="OEV33583">
        <property type="protein sequence ID" value="OEV33583"/>
        <property type="gene ID" value="HS99_0012380"/>
    </dbReference>
    <dbReference type="OMA" id="WSGFMFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="46254" checksum="075732BD3F15BC86" modified="2017-01-18" version="1">MVTVLLGAFLPMLDFFIVNVALPTIDKDLAAGPAVLELVAAGYGIAFAVLLVLGGRLGDIFGRRRLFVVGAATFALTSLACGLAPDAWSLVAARAAQGASAALLIPQVLGTITAATDGARRGRALSVYGAVGGISVVIGQVLGGMLVAADVFGTGWRSVFLLNVPFALLAVVLAVRYVPESRATQAAAVDVPGTALLTATLLSLLVPLMEGRAAGWPLWSWVLLALFPVFATAFALVERRAEQRGAVPLVPPTLLRIPEMRRGLGIAVPYFAGFGGFMFVIAVALQQGLQLGVVAAGWALVPMAVGYFTASLSGPRLIGRWGSRVLSAGAVIQAVGLTTIALTVLADADHFSPLRMAPGVALAGIGQGLIGTPLFRVVLSKVPAARAGVGSGVLATSQQSSLALGVATLGTLYLSLSPSLGMGRALALCLGIQLLGSFTVLYLTTRLPRSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZF1</accession>
    <name>A0A1E7MZF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0037810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387284.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3778"/>
    <dbReference type="EnsemblBacteria" id="OEV33791">
        <property type="protein sequence ID" value="OEV33791"/>
        <property type="gene ID" value="HS99_0037810"/>
    </dbReference>
    <dbReference type="OMA" id="VVVWQVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198577" evidence="6">
        <location>
            <begin position="21"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="482" mass="49607" checksum="6A21E61447EF17E4" modified="2017-01-18" version="1">MLLCLLTIVLAVLDSNIVSAATVPIVHDLDPVHGIDRLPWLVSAFSLAATALLPLYGKLCDVYGAKRVLLGAVGSFLLGSALCGAAQSMGELIAFRAVQGVGGGGLMSVTMVVMAQLQDPEERSRGKGGAVGGIVAGLGMAIGPLVGALFTDHLGWRWIFYVNLPLGLLVLAGFALALKLPQTVERRGLDFLGATLAAAFATGLLLVTEWGGKDYGWTSPVILGTSAATLAALGLFLWRQATAAEPVLPLSLFRIPVVRIGFAVQGLVGMGMMGAIVYVMIYLQVARGIAPTTASLYLMPMAAGMTGAGLLATRLLSRGHRPRTFLVAGAGCSMLALGLLGLSGPDTPLWAVGAELTLLGAGFGQLIGQLITLVQDAAPRHQLGVATTGIRFFQTLGNALGAAVFGTVLSRVFEAGRPGRTLGAVRVVTGPAREQAVRSFTDAVDVVFLSAAGVMVLVLLLALRLRSVESAGAAAEQPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS8</accession>
    <name>A0A1E7MZS8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386469.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1885"/>
    <dbReference type="EnsemblBacteria" id="ARF77788">
        <property type="protein sequence ID" value="ARF77788"/>
        <property type="gene ID" value="B6264_01575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33936">
        <property type="protein sequence ID" value="OEV33936"/>
        <property type="gene ID" value="HS99_0010735"/>
    </dbReference>
    <dbReference type="OMA" id="EGIIWIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="34174" checksum="647BC04DF48EBED8" modified="2017-01-18" version="1">MEPASGARTATSYQEGKAAVIEIQGLTKEYDGRRVVDALSFEVRPGVVTGFLGPNGAGKSTTMRLVLGLDRPTAGQALVNGRPYAQLTEPLRQVGALLDAHALHGGRTAQGHLRWLAASNGLPARRVGEVLAQVGLADVAGRRIRGFSLGMRQRLGVAAALLGDPPVLLLDEPVNGLDPEGIRWIRTLLRELATEGRAVLVSSHLMTEMALTADHLVVIGRGRLLADAATSEFIDRHGRTRVRVRAVDAAKLAALLGGPGHGLDAVEAEGGAWEVTGAEPERIAALAAANGVVLYEIAVQQDSLEEAFMRMTADSVEYRAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N078</accession>
    <name>A0A1E7N078_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366482.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000956.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2339"/>
    <dbReference type="EnsemblBacteria" id="OEV34084">
        <property type="protein sequence ID" value="OEV34084"/>
        <property type="gene ID" value="HS99_0011640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10303" checksum="5FC52EB91D9D5930" modified="2017-01-18" version="1">MRACDSPSERALELIANAWGHGRTPAPVVYFSLTRTLRVCVADESDALPAPRTPSRLAESGRGLQLVEGLTHRWGVDPQKRGKTVWYELDFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0D6</accession>
    <name>A0A1E7N0D6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0011925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366493.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3722"/>
    <dbReference type="EnsemblBacteria" id="OEV34131">
        <property type="protein sequence ID" value="OEV34131"/>
        <property type="gene ID" value="HS99_0011925"/>
    </dbReference>
    <dbReference type="OMA" id="PHETIII"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24492" checksum="0AB575E23FAAA220" modified="2017-01-18" version="1">MPLRSGGSIPAQTPGPGGPVPGPARSIGLLDGLGALARRAVREILLVLPSAPVEPRLRARLELLGAEVVDRGVRVRAVGPENLDDPACGGSADRMAALGVELLAVNQPPLWMAVADRDAAIVPTDPLAEQSGWVFLRGVAPVAACRLLFEQLWEQGRELKPSDGSGDDSGPDRREREVLRLLAEGLTDEAIAARTGLSVRTNRRTIADLMARLGARSRFQAGAEAARRTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0I1</accession>
    <name>A0A1E7N0I1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552006.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1984"/>
    <dbReference type="EnsemblBacteria" id="ARF79570">
        <property type="protein sequence ID" value="ARF79570"/>
        <property type="gene ID" value="B6264_12185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34185">
        <property type="protein sequence ID" value="OEV34185"/>
        <property type="gene ID" value="HS99_0037035"/>
    </dbReference>
    <dbReference type="OMA" id="WIDFDHN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045474">
        <property type="entry name" value="GEVED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20009">
        <property type="entry name" value="GEVED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GEVED" evidence="2">
        <location>
            <begin position="350"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="535"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Big_13" evidence="1">
        <location>
            <begin position="628"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="930" mass="93126" checksum="FAD04AE1209BDDE7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0S6</accession>
    <name>A0A1E7N0S6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280041.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000766.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2327"/>
    <dbReference type="EnsemblBacteria" id="ARF77932">
        <property type="protein sequence ID" value="ARF77932"/>
        <property type="gene ID" value="B6264_02435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34073">
        <property type="protein sequence ID" value="OEV34073"/>
        <property type="gene ID" value="HS99_0011580"/>
    </dbReference>
    <dbReference type="OMA" id="YGHFTSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27674" checksum="FD12C46D47EE3B6F" modified="2017-01-18" version="1">MAEIEIDGAPADPARLAALGLLNYGHFTTLRVEAGGVRGLALHLDRLVRDCRVLFAAELDRGAVRERIRAVLPADGAPVIVRVTVYDPALGLERPAAPATPALLVTTRPAATVEPAPLRVRTVTYRRELPEVKHVGLFGLVHHRRVAQLAGYDDVLLVDDDGLVAEGATWNVGFLAGDRLVRPDGPSLPGVTEALLAGAYGGPQVREPVRTADLARFDAAFALNAGGGLRPLAAVDGTAFDPAHPLLAELRAAYLRIAADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A3</accession>
    <name>A0A1E7N1A3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290801.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1058"/>
    <dbReference type="EnsemblBacteria" id="ARF78946">
        <property type="protein sequence ID" value="ARF78946"/>
        <property type="gene ID" value="B6264_08465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34455">
        <property type="protein sequence ID" value="OEV34455"/>
        <property type="gene ID" value="HS99_0035730"/>
    </dbReference>
    <dbReference type="OMA" id="ELDRPGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14394" checksum="AEB88D350ACD0B81" modified="2017-01-18" version="1">MRVSGAVVVIAVLDGGSGADLARRFTAAGAAGMLIADQHVGIAEDLAAELDRPGCPVVGVCGDIRRPSDVAALVDTAEKHLGPIDLFCVAGPEGERVVSLADLPDHLDLERLAELVALIGEAIGELVPPQRRPSESTATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N213</accession>
    <name>A0A1E7N213_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0009485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4651"/>
    <dbReference type="EnsemblBacteria" id="OEV34711">
        <property type="protein sequence ID" value="OEV34711"/>
        <property type="gene ID" value="HS99_0009485"/>
    </dbReference>
    <dbReference type="OMA" id="EPWDISR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="852"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="922" mass="98992" checksum="AFAD4069BA71E391" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N275</accession>
    <name>A0A1E7N275_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81862">
        <property type="protein sequence ID" value="ARF81862"/>
        <property type="gene ID" value="B6264_25885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34776">
        <property type="protein sequence ID" value="OEV34776"/>
        <property type="gene ID" value="HS99_0009865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="9255" checksum="CFFA4FB05A6B75E7" modified="2017-01-18" version="1">MQWPGTKLQQSPFFLDIQQAVIKRRLTTSAPDYVGYLPTVSAYLQLPQPKRQQAYGAITRVLSETVEIAADIIVHLARRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N292</accession>
    <name>A0A1E7N292_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3199"/>
    <dbReference type="EnsemblBacteria" id="ARF81810">
        <property type="protein sequence ID" value="ARF81810"/>
        <property type="gene ID" value="B6264_25535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34830">
        <property type="protein sequence ID" value="OEV34830"/>
        <property type="gene ID" value="HS99_0010190"/>
    </dbReference>
    <dbReference type="OMA" id="SYRWPIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004705">
        <property type="entry name" value="Cation/H_exchanger_CPA1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00831">
        <property type="entry name" value="a_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0050">Antiport</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0915">Sodium</keyword>
    <keyword evidence="1" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="528" mass="56649" checksum="5A414EC77AC49EC8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N297</accession>
    <name>A0A1E7N297_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trypco1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3220"/>
    <dbReference type="EnsemblBacteria" id="OEV34809">
        <property type="protein sequence ID" value="OEV34809"/>
        <property type="gene ID" value="HS99_0010075"/>
    </dbReference>
    <dbReference type="OMA" id="NCHLTVK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045794">
        <property type="entry name" value="Trypco1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19493">
        <property type="entry name" value="Trypco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypco1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="12833" checksum="047EC906356A4A83" modified="2017-01-18" version="1">MCRRVRRGEGGIVAALARMLLEGGGCVLIEAPAGLGGPVKAGRVGDAIHELPESLQGALQPVTEAARATLDELRKACPDEITVAFGVDLAVEAGAVITKAGATGHLMVTMTWNRNAAGHPGAGESPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2E0</accession>
    <name>A0A1E7N2E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385865.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7613"/>
    <dbReference type="EnsemblBacteria" id="ARF81792">
        <property type="protein sequence ID" value="ARF81792"/>
        <property type="gene ID" value="B6264_25430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34846">
        <property type="protein sequence ID" value="OEV34846"/>
        <property type="gene ID" value="HS99_0010290"/>
    </dbReference>
    <dbReference type="OMA" id="VFTHAHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="33658" checksum="8F7A4237D0AB235E" modified="2017-01-18" version="1">MSTSTTRPTTSSTSTGWSLGDIAVHRVDEIELPRQTGPWLLPAATKEVLDEAAWLRPDFADADAPRLASHSFAVEAGGLRIVVDTGIGNGKNRANPAWNGLDTDFLERLAAAGFPPESVDLVITTHLHTDHVGWNTRLVGGDWVPTFPNARYLTSRTEWDHWAATDLDEARSQMFRDSVHPVRDNGQYHLVDVPEQGHEVAPGVLLVPAPGHTPGQVAVELRGSDRRALITGDSIHHPVQLSHPHVHSCVDIDPAQAVRTRARLLDALADTDALLLGTHFPQPTAGTVRRENGRYRLLAEHGSVMPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2I4</accession>
    <name>A0A1E7N2I4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288576.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000568.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5862"/>
    <dbReference type="EnsemblBacteria" id="ARF77552">
        <property type="protein sequence ID" value="ARF77552"/>
        <property type="gene ID" value="B6264_00170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34909">
        <property type="protein sequence ID" value="OEV34909"/>
        <property type="gene ID" value="HS99_0034925"/>
    </dbReference>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="26639" checksum="559EC4526A7C6ABA" modified="2017-01-18" version="1">MTSAEPLVRVTTADAVTTLTLDSPHNRNALSSRLMSELHAGLAVAAANQDVRAVVLTHTGKVFCAGADLSEATGADPTVGPRGLVELQKAIVDCTKPVIAVVDGHARAGGLGLIGAADLAVAGPAATFAFTEVRLGLAPAVISLPLRPKLEPRAASRYYLTGEVFDAAEAARIGLITQAAGSTEDTGVVLKGLLDALRQGSPQGLAESKRLANAEVVRSFQRDADELVQLSALLFGSAEAQEGMRAFLEKRPAAWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J5</accession>
    <name>A0A1E7N2J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554096.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000889.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5864"/>
    <dbReference type="EnsemblBacteria" id="ARF77550">
        <property type="protein sequence ID" value="ARF77550"/>
        <property type="gene ID" value="B6264_00160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34911">
        <property type="protein sequence ID" value="OEV34911"/>
        <property type="gene ID" value="HS99_0034935"/>
    </dbReference>
    <dbReference type="OMA" id="GCWIGTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27208" checksum="61D67CE71CE50D51" modified="2017-01-18" version="1">MPITRSLLSTVRTGGRRAAGRLVHRGWRWMQRTGAVTNRNPGPYRFGELGDGTTLAFPLGAVFNEQWITIGPFSIIGERVTISAGFLPGLDLGPEPIVRIGGGCVIGRDSHIVGHQSIVIGDDVWTGPGVYVSDQAHEYRDTELPIGKQWPRNEPVEIGAGSWIGTGAVIMPGARIGRNVVVAAGAVVRGEVPDHSVVAGAPAKVVRRWSEEEGWQPPLRHEPPRPVPDGVTAEQLRALVEWDLRLPGEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2K4</accession>
    <name>A0A1E7N2K4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288620.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5887"/>
    <dbReference type="EnsemblBacteria" id="ARF82055">
        <property type="protein sequence ID" value="ARF82055"/>
        <property type="gene ID" value="B6264_27065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34929">
        <property type="protein sequence ID" value="OEV34929"/>
        <property type="gene ID" value="HS99_0035050"/>
    </dbReference>
    <dbReference type="OMA" id="QGVFLRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17947" checksum="DCA8DA388D03519D" modified="2017-01-18" version="1">MSFLRRRSGQPAGPDFDVLAMDPGDWPGDFGAAMMTGPDGSCQGIFLRYDLFGGRGPAMFIGNLPEGSPARETGDEVPFEVRQLLAALENDEPVEFVSAEDFPVMLGDDLLIVKKVKVSEERVFCAQFGRSDGVLVTIASWDRPISDDLYQLLKPLPADMFQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L6</accession>
    <name>A0A1E7N2L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366420.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5898"/>
    <dbReference type="EnsemblBacteria" id="ARF82063">
        <property type="protein sequence ID" value="ARF82063"/>
        <property type="gene ID" value="B6264_27120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34938">
        <property type="protein sequence ID" value="OEV34938"/>
        <property type="gene ID" value="HS99_0035105"/>
    </dbReference>
    <dbReference type="OMA" id="TRCTATS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="33134" checksum="AC40134CE23E77C2" modified="2017-01-18" version="1">MITRLAAASLGAALSMTLLTTGAAVAAPAGTPSTSAQHVTVSQSGNYPGGFFTSGNMAASWVSSGTSDLTGPTHFTVDLPPGVTTDGAMFYSTPYDYTFTETLSPDGRHLEAVLTGTRVVGKSEFMKLSLRTTPGVPVAGVITVTAANPNDTDPTGHVSRYDLGSGSQLPATVQAAPAVTGLGTTTGPGAGGTPVTVSGSNLAHGMVLVGGVPAAGTCTDTACTVTTPGGSGSAPVSVVTPGGTATAPAGFDYTGAAPPAPPAPVVSSLTTTSGPVTGGTGVYVQGANLTYGSIAFGGVPAAHVSCGPSFCSATAPAGAAPGLVDVTVTTAGGTSAPVTYTYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N4</accession>
    <name>A0A1E7N2N4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="8" type="ORF">HS99_0034650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554864.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7676"/>
    <dbReference type="EnsemblBacteria" id="ARF78541">
        <property type="protein sequence ID" value="ARF78541"/>
        <property type="gene ID" value="B6264_06110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34959">
        <property type="protein sequence ID" value="OEV34959"/>
        <property type="gene ID" value="HS99_0034650"/>
    </dbReference>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="470" mass="51928" checksum="5AD6432662E177A7" modified="2017-01-18" version="1">MAKAPVLTPQAEDFPRWYQDLINKAELADNGPVRGTMVIRPYGYGLWERMQQEMDARIKKAGAQNAYFPMFIPQSYLTKEAEHVEGFAPELAVVTHGGGKQLEEPVVVRPTSETIINEYFSKWVQSHRDLPLLINQWANVVRWELRPRIFLRTTEFLWQEGHTAHATYEDARDYASMIHTQVYGDFMTNVLGIDVVLGRKTAKERFAGAINTLTLEGMMGDGKALQMGTSHELGQNFAKAFNTTYQLQGAEREYVWQTSWGVSTRMVGGLIMSHGDDNGLRVPPRLAAVQAVVLAIKGDDAVIAKVREIGAQLEAAGIRVVVDDRTDTPFGRRAVDWELKGVPLRIEVGPRDLENGTAMLARRIPGGKEPVSIDALAALLPGVLEEDQALLLRQSRERREARTVDVKTLDEAVEAAATGWGRIAWADLGAEGEAKLAEQGVTVRCIIAADGSVPQADDQDGNIAIVARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N5</accession>
    <name>A0A1E7N2N5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5889"/>
    <dbReference type="EnsemblBacteria" id="OEV34930">
        <property type="protein sequence ID" value="OEV34930"/>
        <property type="gene ID" value="HS99_0035060"/>
    </dbReference>
    <dbReference type="OMA" id="FVRHRPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="165"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="43817" checksum="5DBF925AE39ADE48" modified="2017-01-18" version="1">MYSSATTPTPTATRTTLRPPTAATGRPGPKQVPPASRPVAPRGTEGRSTDARVPAGRTALGLRTPETAPPVGHRLPLARQADGQVLRARRPGQPLGPERIDPSALQTPAVRAALGSVARICPAFTPRQVLREGSRHILVAGTIGRAPVVAKCLAPQAVRSEYFEQLVADFHHEVAVYRAFVRHRPPVRLPRLVAADHDRCVLVMERVPGRPAARERHPVSAPTPGEVRALLGAVRTLNLWRPPSDVFQPRLDYQLEIARYHSVGQLTDRDAGDLRGLLHGLGHTPLQLCHGDALLSNMLLAPSGPVLVDWEQAGWYLPGYDLALLWSVLSGDTAARRQISQLAQNGGTLARDAFLVNLVLVLMREIRLYDVPGAGEEQRIMIRRLYDDAALARRAVRAAVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S0</accession>
    <name>A0A1E7N2S0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366560.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4568"/>
    <dbReference type="EnsemblBacteria" id="ARF78521">
        <property type="protein sequence ID" value="ARF78521"/>
        <property type="gene ID" value="B6264_05985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34976">
        <property type="protein sequence ID" value="OEV34976"/>
        <property type="gene ID" value="HS99_0034775"/>
    </dbReference>
    <dbReference type="OMA" id="LRLAWCA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="38802" checksum="2738F642746E7798" modified="2017-01-18" version="1">MFYLRLARGYRVPDLGRWLLTALAAAVVAAFLLRSLGRALSEPIGGADALVRLLWCLPPLAAVAWFAAVAARSVPARRPERLAGLTAAGAGSRRIRTLIAGEVALACTLGSVLTLLLFLVLRNDIAGPSLAPDLGMGVPLPAAAPVTLLALVPLTAGIAAACSVPVAETLPGGRTRGRTGFGPLRIAVPIGLVVIGAALELIALRPGAPADGRPIHLPAGLGTTSTAALGGWAAGALGLALLTGPLLAWTGRLLAVGRPTPLRLLAGRGLTAQAPRLGPPLAVLTLVLALVLTTVRYWIGTPNRADALPAVEACLVLGCAAAAVLARLAEVRTDRREVTEALLRLGTSPRLLFGAVALRTLAVGTTLLLTGGATAALAAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2T0</accession>
    <name>A0A1E7N2T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831475.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4556"/>
    <dbReference type="EnsemblBacteria" id="ARF82656">
        <property type="protein sequence ID" value="ARF82656"/>
        <property type="gene ID" value="B6264_05925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35001">
        <property type="protein sequence ID" value="OEV35001"/>
        <property type="gene ID" value="HS99_0034835"/>
    </dbReference>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28427" checksum="4DDE332CBDEB0E47" modified="2017-01-18" version="1">MKWVRAHLVVLAGLLALAYLVLPNLVVLAFSFNKPVGKFNYEWNEFSTDAWTNPCGVADMCQSLSLSLRIAVLATVGATVLGTMVAFALARYRFRGRSATTAMIFLPMAMPEVVMAASLGTLFLNMRIPFGFTTILIAHIMFCLSFVVTAVKARVMSMDPRLEQAAQDLYATPTQTFLRVTLPLAAPGIAAGALLSFALSFDDFIITQFNSGPTTVTFPMFVWGASQRGIPVQVNVIGTAMFVAAVALTVAGQWLGNRRKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2V2</accession>
    <name>A0A1E7N2V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81856">
        <property type="protein sequence ID" value="ARF81856"/>
        <property type="gene ID" value="B6264_25840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34783">
        <property type="protein sequence ID" value="OEV34783"/>
        <property type="gene ID" value="HS99_0009905"/>
    </dbReference>
    <dbReference type="OMA" id="PEGWALW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15416" checksum="28CEC4676E5A662B" modified="2017-01-18" version="1">MQRAVNALARGLRHYHFPGDGCLDDEADRPELKLAGVVILRPGAMPDGMEETYEEACARLGVEARPEGWALWNTWGDGNLQVTMVISAVDTTEGLLANWSRGEAIYPVTPVPSQIALIHHGWAAHMIFSPFGVKKLGLGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N342</accession>
    <name>A0A1E7N342_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286649.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000569.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene407"/>
    <dbReference type="EnsemblBacteria" id="ARF78896">
        <property type="protein sequence ID" value="ARF78896"/>
        <property type="gene ID" value="B6264_08185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35094">
        <property type="protein sequence ID" value="OEV35094"/>
        <property type="gene ID" value="HS99_0034095"/>
    </dbReference>
    <dbReference type="OMA" id="QYELAMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21751" checksum="F17D207610F0C1BF" modified="2017-01-18" version="1">MAHVPASERRPQLVRAAIDLMTREGVAAASTRAIAAELGVAQATVHYTFGTKKDLYRAVVEEVAAQFIGQVRAASPGDGPFGEQVRTLVHALWEAATGEDGRCVLLSEFETLAMRDPDVREIMLGLQRAIEGTAGEMIGALAAAHGLTLAAPAGRIAVHFLSGFDGLTARHLIRRHPGEQPDPETLAALDVLVATTVGLCLGEAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P3</accession>
    <name>A0A1E7N3P3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5338"/>
    <dbReference type="EnsemblBacteria" id="OEV35321">
        <property type="protein sequence ID" value="OEV35321"/>
        <property type="gene ID" value="HS99_0033225"/>
    </dbReference>
    <dbReference type="OMA" id="SDPFGMC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="47203" checksum="D8C1792ED6DB1259" modified="2017-01-18" version="1">MASSDQTGGLRAGLRGLTTRGRSFLAAGLTAVVCAYVLDQDALLRVGVLLAALPLAAALVVANTRYRVASGRRLSPHRAIAGQEARVHLRVDNVSRVPTGLLLLEDKVPYVLGPRPRFVLDRVEPRGFREVSYRVRSDLRGRYPLGPLQLRLSDPFGMCEVNRGFSASDVLTVVPQVQALPQVRLTGEWIGQGESHARTLALAGDDDVILREYRPGDDLRRVHWRSTARYGELMVRREEQPQKARATVLLDTREVGHRGSGPASSFEWAVSCAASVAVHLLERGYQTQLLTDTGQWVPGPGTGGQNLAADTSGLILDALAVADLSDGAGLSRAEEPLRAGGEGLLVAVLGDLDGAQAARLARLRSRTGGAIAFLLDTGTWAGLRMIAPDTGGDPFRDRVRELRAAGWTVLPVRAGDSLPDLWRAADGAKTTAPYREEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3S5</accession>
    <name>A0A1E7N3S5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278742.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2444"/>
    <dbReference type="EnsemblBacteria" id="OEV35340">
        <property type="protein sequence ID" value="OEV35340"/>
        <property type="gene ID" value="HS99_0032475"/>
    </dbReference>
    <dbReference type="OMA" id="WRLMATG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25594" checksum="83DF9DC7C31B6CD2" modified="2017-01-18" version="1">MTDRSHPGDGAGTAVKVLVVDDQPLVRRGLSLILSPDPSLHVVGEAEDGEQAVAAALRLRPDVVVMDIRMPVLDGVGATERLARVLPDCRVLALSTFDMDEYVVAALRAGAHGFLPKDVSPEDLAAAIRTVHAGEAVVAPRLLTRLISTYVRAPVAAAAPAPPAPGTGELTPREVEVWRLIATGLDNAAISLALDISQSTVKNYITSIFGKLDVRDRAQAVIAAYESGLVTARTGNGDQAERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N423</accession>
    <name>A0A1E7N423_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290462.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1614"/>
    <dbReference type="EnsemblBacteria" id="OEV35436">
        <property type="protein sequence ID" value="OEV35436"/>
        <property type="gene ID" value="HS99_0032265"/>
    </dbReference>
    <dbReference type="OMA" id="GHYLHWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6602" checksum="8A26758E9B789833" modified="2017-01-18" version="1">MTAAPTTGAFAAPVDLNHPGHYLHWGVVQISVANLVVMCLMVTLFVAALLLPFPRGRRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N478</accession>
    <name>A0A1E7N478_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386265.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79387">
        <property type="protein sequence ID" value="ARF79387"/>
        <property type="gene ID" value="B6264_11060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35498">
        <property type="protein sequence ID" value="OEV35498"/>
        <property type="gene ID" value="HS99_0031870"/>
    </dbReference>
    <dbReference type="OMA" id="YEPFFLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16373" checksum="676A7DB564FFC3D1" modified="2017-01-18" version="1">MKTTVLRAAAYAAATWSAAFSLVHLYWLLGGRTGLPDGLSVTGNTPLLVIDVLAVPGCAVAAVLALAGVRPWGGRLPGRLLDFALRGIAAVLLVHSVPSVPDWLALATGARTTADFDAMGRFATLLYEPFFMTGGLLFGLSALGRRAPLNSASPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N481</accession>
    <name>A0A1E7N481_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5272"/>
    <dbReference type="EnsemblBacteria" id="OEV35263">
        <property type="protein sequence ID" value="OEV35263"/>
        <property type="gene ID" value="HS99_0032895"/>
    </dbReference>
    <dbReference type="OMA" id="MIFRAKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="41"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28747" checksum="B83A92E8855515ED" modified="2017-01-18" version="1">MGLIFRSKANKALDRAEDPRETLDYSYQKQLELLQKVRRGVADVATSRKRLELQLTQLQQQSAKYEDQGRKALSLGREDLAREALTRKANMQSQINDLETQYQQLQAEEEKLTLASQRLQAKVDAFRTKKETIKATYTAAQAQTRIAESFSGISEEMGDVGLAIQRAEDKTAQMQARAGAIDELLASGALDDASGLGRKDDIEAELERVAGGSDVELELARMKAELSGGPAAGPAAIEQGKPAQQPQDSHSQDTPRINYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4A2</accession>
    <name>A0A1E7N4A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030240061.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5296"/>
    <dbReference type="EnsemblBacteria" id="ARF80709">
        <property type="protein sequence ID" value="ARF80709"/>
        <property type="gene ID" value="B6264_18955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35283">
        <property type="protein sequence ID" value="OEV35283"/>
        <property type="gene ID" value="HS99_0033015"/>
    </dbReference>
    <dbReference type="OMA" id="ETHIAFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10106" checksum="94880A8B4A864E8E" modified="2017-01-18" version="1">MITAIVLIKTSVDRIPEIAEAIAAIEGVSEVYSVTGGYDLVAMVRVRRHDDLAEVIPGRLNKVPGVAHTETQIAFRTYSQHDLEAAFALGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4G3</accession>
    <name>A0A1E7N4G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550057.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5374"/>
    <dbReference type="EnsemblBacteria" id="OEV35581">
        <property type="protein sequence ID" value="OEV35581"/>
        <property type="gene ID" value="HS99_0006580"/>
    </dbReference>
    <dbReference type="OMA" id="ERRYEYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="30049" checksum="4ECEFBD914DF7F6D" modified="2017-01-18" version="1">MAERRYEYAPAGTLPGLLQRGRGLGALMAAEDPGAAAELVYGCIRWEWRWDPRVDERGRYLARLIRDLELPLGPVVEVLSGAEEARARAVRVLGLLALGGSAEAREALGARGALGALGASASAWRERAGAGAGSAVGHGEERDVPALVAELERAWVDRAWCGPTRLARGLARFGPEAADAVSLLRRFWLQTPHSSERAAYLEALAALGSAGMAEAYTESLWDCEADARLLGAEHAPDTPQVRARLAFLRDDPIEEPEVSNTAGARLAGLAPAGGLRGCVSRGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M8</accession>
    <name>A0A1E7N4M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551180.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80841">
        <property type="protein sequence ID" value="ARF80841"/>
        <property type="gene ID" value="B6264_19745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35648">
        <property type="protein sequence ID" value="OEV35648"/>
        <property type="gene ID" value="HS99_0006975"/>
    </dbReference>
    <dbReference type="OMA" id="WWAGHRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="32379" checksum="9ECFE0FB99D686E8" modified="2017-01-18" version="1">MDRTKEIAGFLRSRRARVTPEEAGLPADGRVRRVPGLRRDEVARLAGVSTEYYTRLEQGRALNPSAEVVDAITRALRLDDTEREHLTDLLHSGTQRPRRAAPATKAQRVRPGLYLMLETLDHVPAFILGRRTDVLASNRLAREVLTDFDALPATHRNLARYYLLDPRARERVGDWARIAAETVAMLRLEAGRYPDDRRLADLVGELTLRSPEFTGWWNDHRVLRRTHGAKHYHHPLVGDLHFSYESFQVPGDAEQTLCVYNVEPGSETAQSLLVLASWTAPGIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4N8</accession>
    <name>A0A1E7N4N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281786.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene923"/>
    <dbReference type="EnsemblBacteria" id="ARF80849">
        <property type="protein sequence ID" value="ARF80849"/>
        <property type="gene ID" value="B6264_19785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35656">
        <property type="protein sequence ID" value="OEV35656"/>
        <property type="gene ID" value="HS99_0007015"/>
    </dbReference>
    <dbReference type="OMA" id="FPRRMMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8408" checksum="2F729C471ECBD515" modified="2017-01-18" version="1">MALHKLGQDPDSPEGKSPTVYFDDVTGNYILQGWRVLDPARLAHMDVPEHETVIEFPRRMMQFFPEVNGGGGTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4P9</accession>
    <name>A0A1E7N4P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme GlgX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281756.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene906"/>
    <dbReference type="EnsemblBacteria" id="ARF80865">
        <property type="protein sequence ID" value="ARF80865"/>
        <property type="gene ID" value="B6264_19870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35671">
        <property type="protein sequence ID" value="OEV35671"/>
        <property type="gene ID" value="HS99_0007100"/>
    </dbReference>
    <dbReference type="OMA" id="HAFVNDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="715" mass="80335" checksum="02B41C0032353685" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U5</accession>
    <name>A0A1E7N4U5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386637.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene842"/>
    <dbReference type="EnsemblBacteria" id="OEV35718">
        <property type="protein sequence ID" value="OEV35718"/>
        <property type="gene ID" value="HS99_0007435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13398" checksum="CFDA7DDC3ABE2731" modified="2017-01-18" version="1">MFSLELPPDWSVPREELREATSRAGWKPDLVADAEVALLELFVNAWRHGGSAAPLVVVLIIGSVLRVSVSDQNPLFPAQRDDPDPYAVSGRGLHLVRSLTHRFGTEPRKAGKSVWFELDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y0</accession>
    <name>A0A1E7N4Y0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35704">
        <property type="protein sequence ID" value="OEV35704"/>
        <property type="gene ID" value="HS99_0007325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="9249" checksum="1CB521CE411B6141" modified="2017-01-18" version="1">MAAIAGSSQSGMESPEEGGSPPDSTGASRPEASAGGVRTELRRVAWAGGRTAGGGCTAGAPGGRDGPCDSGSVGMLLLPLPWRTAPTVRTGRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z5</accession>
    <name>A0A1E7N4Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5480"/>
    <dbReference type="EnsemblBacteria" id="ARF79422">
        <property type="protein sequence ID" value="ARF79422"/>
        <property type="gene ID" value="B6264_11260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35533">
        <property type="protein sequence ID" value="OEV35533"/>
        <property type="gene ID" value="HS99_0032070"/>
    </dbReference>
    <dbReference type="OMA" id="YVLQVHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="34345" checksum="621672DCDE8876AF" modified="2017-01-18" version="1">MPAPSPNPAPAPSAGRPAPAGGFADALHLAIEASGLSLDRIRAALAQRGVRVSVTTLSYWRRGRSQPERASSLRAVHLLEELLGLPHSALSSLLGPPRPRGRWAAAANTLHLGLEDVWPGEQEIAAIFAELDAPPAGELERLSIHDSYYVDAERRGNLLRMRQVVRATVGGVGRCMVVHKADEEATGCPEITSVRHGRLGRVRRRADTGLTVAELMLDRPLGLGDSTVFEYEVEIPPGGPTMEYSRRFATPVREYVLQVHFDPAAVPAHCERYDREPGADVDHRREQLWIGASASAHVLAPDQQPGHIGIRWEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N514</accession>
    <name>A0A1E7N514_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278200.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000175.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5494"/>
    <dbReference type="EnsemblBacteria" id="ARF82761">
        <property type="protein sequence ID" value="ARF82761"/>
        <property type="gene ID" value="B6264_11190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35553">
        <property type="protein sequence ID" value="OEV35553"/>
        <property type="gene ID" value="HS99_0032000"/>
    </dbReference>
    <dbReference type="OMA" id="TLGLFHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13756" checksum="C09529120FF46D96" modified="2017-01-18" version="1">MKGFVIKTLINAAAIWVAAWIVSGIQLAQGNADWQHKALTVLGVAVVFGLINWLIKPVVKLFSFPLFILTLGLITFVINALMLLLTSWASNRLELDFHVVDFGAALFGSLIISLVAWGLHLALDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5B7</accession>
    <name>A0A1E7N5B7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366883.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000215.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7271"/>
    <dbReference type="EnsemblBacteria" id="ARF81102">
        <property type="protein sequence ID" value="ARF81102"/>
        <property type="gene ID" value="B6264_21290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35891">
        <property type="protein sequence ID" value="OEV35891"/>
        <property type="gene ID" value="HS99_0008515"/>
    </dbReference>
    <dbReference type="OMA" id="MTQVTPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="376" mass="37598" checksum="9B0BFBA4A582200B" modified="2017-01-18" version="1">MSEQIPAGWYPDPKDTTSDPRPQRWWDGKGWTADTRPAPSDAPQPESSAAAAPGPETSEQPRVLEGEVLDSGPTVRYPEPPPFGTAYGAPAQPPRKAWRKPSRLVVATAVAAVLGLGAGSGITYLVMDGKHDGGSQRSAARAQPAPNDGGGGLFGFPGLGGGNGKGGGNGGGGGNGGGKARPGANKAIDMVNGLTLPVPSGWQGGTTDNGYAGLTIGDYKCPDGSDKCTLGGVNTGRIDGGGTDAQAAAKADIDKAAKDAYGDITGHQELKSEAVKVNGKDGYLVRWKVDAAKGNNGYVETVVFPSSDGKNLVSVHFGFDIADKAPDVGVMDTIVKGIADFKGKIPGLPGMPGSGSGGSGSGAGGSSPDGSGTEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C5</accession>
    <name>A0A1E7N5C5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281793.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene926"/>
    <dbReference type="EnsemblBacteria" id="ARF80846">
        <property type="protein sequence ID" value="ARF80846"/>
        <property type="gene ID" value="B6264_19770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35653">
        <property type="protein sequence ID" value="OEV35653"/>
        <property type="gene ID" value="HS99_0007000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026496">
        <property type="entry name" value="GRASP_targ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025744">
        <property type="entry name" value="Rbsml_synth_pep_Strp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14404">
        <property type="entry name" value="Strep_pep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04186">
        <property type="entry name" value="GRASP_targ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="7694" checksum="9155A0AB96977FE4" modified="2017-01-18" version="1">MTTASAERQPFAMRYAARQTSEPADTTSVTYDQGLQIAVTSDGNPWAHTALGETSSNTNSDSRNDEGTDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I0</accession>
    <name>A0A1E7N5I0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0007185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene889"/>
    <dbReference type="EnsemblBacteria" id="OEV35950">
        <property type="protein sequence ID" value="OEV35950"/>
        <property type="gene ID" value="HS99_0007185"/>
    </dbReference>
    <dbReference type="OMA" id="IFQSHAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28785" checksum="20313378C4498428" modified="2017-01-18" version="1">MTTEADAPVLDSDGGAPAVRISHVHKSFGRPGAQTHVLDDITLDVAPGEFVTLLGASGCGKSTLLNLVAGLDKPSRGSIEVPGGRPALMFQEHALFPWLTAGKNIELALKLAGVPRPERRAEAERLLELVRLGGAYGKRVHELSGGMRQRVAMARALAQGSKVLLMDEPFAALDAITRDVLHDEITRIWAERQLSVLFVTHNVREAVRLAQRVVLLSSRPGRVAREWRIDLPQPRRIESSGVADLSIEITEELRGEIRRHVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5N0</accession>
    <name>A0A1E7N5N0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80973">
        <property type="protein sequence ID" value="ARF80973"/>
        <property type="gene ID" value="B6264_20520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35763">
        <property type="protein sequence ID" value="OEV35763"/>
        <property type="gene ID" value="HS99_0007745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15128" checksum="6B0AF433E4CC1A11" modified="2017-01-18" version="1">MEKSLFSALAASRVCNCLSWSSERLPPLDVRSVARLASATGPPPPGVGLKAVVLVPMSLWRSTVARWSAVVAFSTALARRSDMALALALASRSFANLSLSGSFLAPFGRLQLTEVGLVQFLEGNHPFVPPVLVSGPRSGRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Q9</accession>
    <name>A0A1E7N5Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287500.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene515"/>
    <dbReference type="EnsemblBacteria" id="ARF78805">
        <property type="protein sequence ID" value="ARF78805"/>
        <property type="gene ID" value="B6264_07650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36030">
        <property type="protein sequence ID" value="OEV36030"/>
        <property type="gene ID" value="HS99_0031475"/>
    </dbReference>
    <dbReference type="OMA" id="PKYQRLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="30526" checksum="61E6CE8720C15BFD" modified="2017-01-18" version="1">MTIPRGTAQSPKYQRLAADLRRRIAEGEFTTDAALPVESELERQYGVARNTVRLAVDVLVNEGRLVRLQGKGTYLREHPVLDHHAYGPTLPPAPRDCLAAPSDVYLGEAAEAGRELSTDFEMMIVRARVDIAERLGLRPGETIVVRRQLRLLDREPYSIEESHYRAGLAAGTPLMEPDPVEGGDEAVLAALGRTEIGAVDHLVARMPGPEEAQWFQGGPGVPLVVQTRVTYDRRGPVRVIETRYSADRSRLVYGIGDLSARTTLPAPATPVDPARADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5W3</accession>
    <name>A0A1E7N5W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551253.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6329"/>
    <dbReference type="EnsemblBacteria" id="ARF82684">
        <property type="protein sequence ID" value="ARF82684"/>
        <property type="gene ID" value="B6264_07550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36068">
        <property type="protein sequence ID" value="OEV36068"/>
        <property type="gene ID" value="HS99_0031575"/>
    </dbReference>
    <dbReference type="OMA" id="CEEWYER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="578" mass="61781" checksum="27487A06EA29DFBB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X7</accession>
    <name>A0A1E7N5X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="7">The heme is bound between the two transmembrane subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4955"/>
    <dbReference type="EnsemblBacteria" id="OEV36079">
        <property type="protein sequence ID" value="OEV36079"/>
        <property type="gene ID" value="HS99_0030895"/>
    </dbReference>
    <dbReference type="OMA" id="WSWVAHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000178">
        <property type="entry name" value="SDH_cyt_b560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared with second transmembrane subunit</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000178-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="13037" checksum="DF0CF2E1AE7B760D" modified="2017-01-18" version="1">MWSWVAHRVTGVLIFFFLFAHVLDTALVRVSPESYDTVIQTYKTPLVNLMEYGLVAAILFHALNGLRVVAVDFWSKGPKYQKQMLWTVVGVWVVLMAGSFYGILQHTLISWFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z3</accession>
    <name>A0A1E7N5Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286175.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7250"/>
    <dbReference type="EnsemblBacteria" id="ARF81085">
        <property type="protein sequence ID" value="ARF81085"/>
        <property type="gene ID" value="B6264_21185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35873">
        <property type="protein sequence ID" value="OEV35873"/>
        <property type="gene ID" value="HS99_0008410"/>
    </dbReference>
    <dbReference type="OMA" id="GDASYSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="36588" checksum="238511DCFE16357F" modified="2017-01-18" version="1">MFVAWRDLRFAKGRFALMGTVIVLITVLVGLLSGLTAGLGRQNISAIEGLPADHLVFGKPADGQELNFTDSQVTPDQWQAWAREPGVTSAQPLGITTTKAAAGQRTAALSAFGVPDGSDLAPQGGRVGPGRAVLSTAAAEKLGNLTDGADFTLAGHRLTVAAVEGDAAYSHTPVIWTSLTDWQQFAPGGTGHATVVALRTTAGADLAAADARHGTETRTRDDALAAIGSYTSENGSLQLMRGFLFAISALVIGAFFTVWTIQRSGDVAVLKALGASTRYLLRDALAQAVLLLVLGTAVGTAIALGAGSLIGSAVPFVLDAPTLLLPAAVMIALGAVGAALSIRRITSVDPLTALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C8</accession>
    <name>A0A1E7N6C8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79841">
        <property type="protein sequence ID" value="ARF79841"/>
        <property type="gene ID" value="B6264_13835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36229">
        <property type="protein sequence ID" value="OEV36229"/>
        <property type="gene ID" value="HS99_0030780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="687" mass="70089" checksum="8B35C800D88FC9F0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H9</accession>
    <name>A0A1E7N7H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000524.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7781"/>
    <dbReference type="EnsemblBacteria" id="ARF82287">
        <property type="protein sequence ID" value="ARF82287"/>
        <property type="gene ID" value="B6264_28485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36628">
        <property type="protein sequence ID" value="OEV36628"/>
        <property type="gene ID" value="HS99_0028025"/>
    </dbReference>
    <dbReference type="OMA" id="WRACDPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14393" checksum="56B1996E3FB36FD5" modified="2017-01-18" version="1">MERVTTRITMRLMTGDERSRDLDVDWSYRATEPHAVELDFTSYQAGAVWALSRDLLLSGLHEPSGEGDVHITPYEDTRLLIALAGQEGVALLAVPAGAVARFLAATVRLVPPGQEHARIDWDRGLEDLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I2</accession>
    <name>A0A1E7N7I2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550740.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2522"/>
    <dbReference type="EnsemblBacteria" id="OEV36656">
        <property type="protein sequence ID" value="OEV36656"/>
        <property type="gene ID" value="HS99_0028225"/>
    </dbReference>
    <dbReference type="OMA" id="NGHEYGN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="19794" checksum="6A0F8B003CF3B35C" modified="2017-01-18" version="1">MTDPLSSTTPQPGIEPEIPEVPPLAPRRRRAERLRAWAGGRERRIAASVAAVALLAGGGLAVAAAAHEGHGERGHGHGQREAAARSEDGNGHEYGNGHEYGNERGTGNEHGKQRGHGHGEAPAPLPSFAASAALDKAQAAVPGGRAESLSRVTAQGGGAAWAVTVVGQDGVRHLVTVDGTDGQLTSNTVVDGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N833</accession>
    <name>A0A1E7N833_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TENA_THI-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829783.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4766"/>
    <dbReference type="EnsemblBacteria" id="OEV36828">
        <property type="protein sequence ID" value="OEV36828"/>
        <property type="gene ID" value="HS99_0027390"/>
    </dbReference>
    <dbReference type="OMA" id="YTHFLSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21502" checksum="1B18EC91582AC3B4" modified="2017-01-18" version="1">MRAELAPGDFAPALVTALADGSAPLTAVAELAAQQHRIITSDRRSLLLLATRCADRPLGAWFATLAEGESAALRTLPALAAACGLDGRAVADRPPLPGCQAYPAYLAWLALNSVPPAAVAALVANFAAWGGYCATIARALRRHHGFSDEACAFFDFFAQPATELEQRAADALGPDPLDGLTLATAREYGLLLQAYEHLFWSTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N874</accession>
    <name>A0A1E7N874_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033350312.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6462"/>
    <dbReference type="EnsemblBacteria" id="ARF78674">
        <property type="protein sequence ID" value="ARF78674"/>
        <property type="gene ID" value="B6264_06880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36879">
        <property type="protein sequence ID" value="OEV36879"/>
        <property type="gene ID" value="HS99_0026805"/>
    </dbReference>
    <dbReference type="OMA" id="PDGAYPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="11394" checksum="C3FB4C5F7FE4479A" modified="2017-01-18" version="1">MSPDAAGWDFSALEVTGRMPVTNRGEGLVELTLEPLGEDYWLRPGETFIVTSYGDHGSGHPFEVQYWPDSVSVWCTSWFGTVSDDEGNQLSSGHQRPDGAYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8J5</accession>
    <name>A0A1E7N8J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284589.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4832"/>
    <dbReference type="EnsemblBacteria" id="ARF82427">
        <property type="protein sequence ID" value="ARF82427"/>
        <property type="gene ID" value="B6264_29305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36793">
        <property type="protein sequence ID" value="OEV36793"/>
        <property type="gene ID" value="HS99_0027705"/>
    </dbReference>
    <dbReference type="OMA" id="MMVLWER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17282" checksum="9C6992205837D2CC" modified="2017-01-18" version="1">MTTLPGMADEELLRLDQQICFSLNAASRAFGGVYRVLLRDLGLTYPQYLVMLVLWEDGELPVKRIGERLRLDSGTLSPLLKRLETAGLVRRERSQEDERSVTVTLTAEGSALRGRAGQVPRRLLAATGLPVEDLAALRELLDRVTVALDSADVEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M3</accession>
    <name>A0A1E7N9M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37368">
        <property type="protein sequence ID" value="OEV37368"/>
        <property type="gene ID" value="HS99_0006200"/>
    </dbReference>
    <dbReference type="OMA" id="GDWYIQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="14759" checksum="59EA7C3C6914E6DF" modified="2017-01-18" version="1">MLIATNERGHVVKRPSKPAIGTMLANLRRGNAHMVLERVDERQPGSWYIQVRLRENNTFQLEYRDGVAELHYQTLTISQEKVLGALLGWAGAKPGWRDGFMWNNIGEQFGPSDCESPEPSGGTKPSTDPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U4</accession>
    <name>A0A1E7N9U4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37452">
        <property type="protein sequence ID" value="OEV37452"/>
        <property type="gene ID" value="HS99_0005865"/>
    </dbReference>
    <dbReference type="OMA" id="WPDMPLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="25971" checksum="C2962D82A6BB1FE3" modified="2017-01-18" version="1">MAPTRSWALERNDRRVDFLTDPTATMFAESGPFQVTRHRHPAWKVVLSLAGPIEVRHADGVMASTGMIVPPQLVHTCATSSAYVALFLDPWKLRSASGPCRLDVAETQRVLDALGPTSEASAHADLAAACAELTRLHGEAASLDPRLAHAVGEYTRPDHDAGIEAVAAGVGISPSRLRALARDAVGIPLTRLRQWARLRVAVADLPRETVAAAAASAGFADQAHLTRTARRLTGRTPSSVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA15</accession>
    <name>A0A1E7NA15_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0026365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286541.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1159"/>
    <dbReference type="EnsemblBacteria" id="ARF79035">
        <property type="protein sequence ID" value="ARF79035"/>
        <property type="gene ID" value="B6264_08990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37535">
        <property type="protein sequence ID" value="OEV37535"/>
        <property type="gene ID" value="HS99_0026365"/>
    </dbReference>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Proton_antipo_N" evidence="7">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="135"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="631" mass="67499" checksum="B539CCFC3C63729A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA21</accession>
    <name>A0A1E7NA21_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5462"/>
    <dbReference type="EnsemblBacteria" id="OEV37333">
        <property type="protein sequence ID" value="OEV37333"/>
        <property type="gene ID" value="HS99_0005980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="24554" checksum="D00F2C26DC5ECEF6" modified="2017-01-18" version="1">MCPVAALCPFSLRPAGAGRVWTAMPQRVIADTGHVVTLAYWPGIESLAPTTWITATRTGDDTTRKQGLQDLAAGTWTLGRYRWTGTELLSHFLAGEWFSVHCFQDATTHEPLRWYVNFEKPYQRRPGGIDTLDLCLDLVVTPDQSGHHWKDRDEYSQLRRLGLIDDYLHHQVEQAQGRPIAMLDNHTGPFAAGWPTWAPDPSWPLPTLPDDADDPAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA48</accession>
    <name>A0A1E7NA48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366619.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1143"/>
    <dbReference type="EnsemblBacteria" id="ARF79023">
        <property type="protein sequence ID" value="ARF79023"/>
        <property type="gene ID" value="B6264_08915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37548">
        <property type="protein sequence ID" value="OEV37548"/>
        <property type="gene ID" value="HS99_0026440"/>
    </dbReference>
    <dbReference type="OMA" id="HRTDEPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="638" mass="68872" checksum="485E2B4E09B85466" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAA8</accession>
    <name>A0A1E7NAA8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386543.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1115"/>
    <dbReference type="EnsemblBacteria" id="OEV37598">
        <property type="protein sequence ID" value="OEV37598"/>
        <property type="gene ID" value="HS99_0026580"/>
    </dbReference>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="14874" checksum="5708281B344CA020" modified="2017-01-18" version="1">MVDVSGKATTARTAVAAGRVRVSPKVVELLRGEGVPKGDALAVARIAGIMGAKRTPDLIPLCHPIAVSGVKVDLAVADDAVEITATVKTADRTGVEMEALTSVTVAALTVIDMVKAVDKGAAIESVRVLSKTGGKSGDWFAPEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV9</accession>
    <name>A0A1E7NAV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556755.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6029"/>
    <dbReference type="EnsemblBacteria" id="ARF78032">
        <property type="protein sequence ID" value="ARF78032"/>
        <property type="gene ID" value="B6264_03040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37832">
        <property type="protein sequence ID" value="OEV37832"/>
        <property type="gene ID" value="HS99_0024945"/>
    </dbReference>
    <dbReference type="OMA" id="TAGWCCR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="27582" checksum="EFEC3B705FC0283F" modified="2017-01-18" version="1">MSAPRTEPVPALVRVAALDLRVLRALPFATVCVVLAAAGHALESGSPVPLGALLLGWVLTTVAAVTGARRERSMGAIVGGLAAGQAGLHVLFHAAQSLRPPPRPAGADGSGHAPDMGDMPGMAHMPGMLATGGGHSGAAVPHVAAGSTGAPHAVAAATHAAFWCHALHLGLSPAMLVAHLAATVAAGWWLQRGEAAVWRLVRLTAGAVTATAHACAAPLHGLLALFAVLRCGVDGRSRARAVRFASADGQRRVPQSALLRHAVIRRGPPPVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBJ3</accession>
    <name>A0A1E7NBJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2012"/>
    <dbReference type="EnsemblBacteria" id="OEV38024">
        <property type="protein sequence ID" value="OEV38024"/>
        <property type="gene ID" value="HS99_0024340"/>
    </dbReference>
    <dbReference type="OMA" id="VLVFTTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="21350" checksum="BE97AEF7E30AB0B3" modified="2017-01-18" version="1">MLVCDDHAVVRAGLLALLASAGDIEVVGEASTGEEAVALAAELAPQVVLMDLQLGDGIDGVEATRRITAAPGGPHVLVLTTYDTDADITRAIAAGATGYLLKAERPEELFAAVHAAAQGRTVLSPPVASRVMAQMRAPSPQLTEREQDILEQLAQGLGNREIARTLFISEATVKTHLGRIYDKLGVDTRAGAVAVAKERRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM4</accession>
    <name>A0A1E7NBM4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288528.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000685.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3047"/>
    <dbReference type="EnsemblBacteria" id="ARF79735">
        <property type="protein sequence ID" value="ARF79735"/>
        <property type="gene ID" value="B6264_13215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38054">
        <property type="protein sequence ID" value="OEV38054"/>
        <property type="gene ID" value="HS99_0022885"/>
    </dbReference>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="25118" checksum="9673DD9EE5DCA141" modified="2017-01-18" version="1">MRDAYHEELDAIGDSLVEMARLVGSALGRATTALLDADLALAEGVIAADEKINDLHHELENRAIDLLARQQPVATDLRIVVTSLRMSADLERCGDLARHVAKVARMRYPESAVPADLQSTVLEMGQLAQRLVAKAGLVIATKDVDKALEMEQDDDRIDALHRELLSHLIDERWHHSIETAVDITLVGRYYERFADHAVSVAKRVVYLVTGEHVAEFVAAAEAAEAAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU7</accession>
    <name>A0A1E7NBU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1906"/>
    <dbReference type="EnsemblBacteria" id="ARF79632">
        <property type="protein sequence ID" value="ARF79632"/>
        <property type="gene ID" value="B6264_12590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38157">
        <property type="protein sequence ID" value="OEV38157"/>
        <property type="gene ID" value="HS99_0023495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="15798" checksum="B7E0B031FA7183C6" modified="2017-01-18" version="1">MRRLPAFAGAVLAGALALSGCSGSHGDEADCPPPVAPRPASPAAATPTAAASTGAEEDTAERGGSHGSSGSHGSSGSKGSSGSKGSSGSKSGGTVHHHVDHHDSNDVVGGHGHCSGGSAPVNEDTGAPFGGGVNTPAPSQSPTPTVVPTPVAPPAKPLPSPTGKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC06</accession>
    <name>A0A1E7NC06_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82804">
        <property type="protein sequence ID" value="ARF82804"/>
        <property type="gene ID" value="B6264_13105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38184">
        <property type="protein sequence ID" value="OEV38184"/>
        <property type="gene ID" value="HS99_0022995"/>
    </dbReference>
    <dbReference type="OMA" id="HEFAVQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="27042" checksum="446999B7205093A9" modified="2017-01-18" version="1">MPGGRAQPKTDKSEATRALILETAMRLFQERGYEKTTMRAIATEAGVSVGNAYYYFSAKEFLIQGFYDRMTHDHAADARRRMAHTRDFSERLQIALTSWLDTAAPYHEFAAQFFRTAADPTSSLSPFSNESHPARATAVELFRDVLQGSDLAPKLDAELVELLPDVLWLNLMVVVLYWVFDRTEDTERTREFVRRSTPMAARLINLSRYRVFRPIVRDAKGLIQDFILPTIGKTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB4</accession>
    <name>A0A1E7NCB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4133"/>
    <dbReference type="EnsemblBacteria" id="OEV38330">
        <property type="protein sequence ID" value="OEV38330"/>
        <property type="gene ID" value="HS99_0022695"/>
    </dbReference>
    <dbReference type="OMA" id="HIVWDWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="202" mass="21621" checksum="0D39F96A7707E6FF" modified="2017-01-18" version="1">MDAVLGASNAAFATIGVGPMTMQQYREQYEIPIPRFYERLLGRMPSQEEWLRLDDAFQDRYRELSPACGLTEGVPELLAGWQAAGHSQSLLSMYVHDKLVPLVDSFGLTGSFLRVDGRSGPPGGQKADQLTKHLAALGEWVDPARTVLIGDAADDALAALHAGAHAVLYTGGSHTREKLEPVGVPVVDSLAEAVELAGQLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCF0</accession>
    <name>A0A1E7NCF0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0022730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4126"/>
    <dbReference type="EnsemblBacteria" id="OEV38370">
        <property type="protein sequence ID" value="OEV38370"/>
        <property type="gene ID" value="HS99_0022730"/>
    </dbReference>
    <dbReference type="OMA" id="VYAMREK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="166"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="26033" checksum="DB2357E20A1ED45A" modified="2017-01-18" version="1">MPPGPEEEPAYAPHRGEPIRVLVVDDHALFRRGLEIVLAEEPDIKVVGEAGDGAEAVLKAADLLPDIILMDVRMPRRSGIEACTAIKDVAPSTKIIMLTISDEEADLYEAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRRSDDRDLVPAPRLTDRELEVLKLVATGMNNREIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCJ6</accession>
    <name>A0A1E7NCJ6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0021070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554470.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene270"/>
    <dbReference type="EnsemblBacteria" id="OEV38405">
        <property type="protein sequence ID" value="OEV38405"/>
        <property type="gene ID" value="HS99_0021070"/>
    </dbReference>
    <dbReference type="OMA" id="HPAGRIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="282"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="587" mass="61161" checksum="4B4F181499FBDEF3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCU3</accession>
    <name>A0A1E7NCU3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0021080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737810.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000605.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene272"/>
    <dbReference type="EnsemblBacteria" id="OEV38526">
        <property type="protein sequence ID" value="OEV38526"/>
        <property type="gene ID" value="HS99_0021080"/>
    </dbReference>
    <dbReference type="OMA" id="LWHANSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="949" mass="101401" checksum="3F71E6B93091F469" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI1</accession>
    <name>A0A1E7NDI1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0018900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286338.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000523.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7331"/>
    <dbReference type="EnsemblBacteria" id="ARF81156">
        <property type="protein sequence ID" value="ARF81156"/>
        <property type="gene ID" value="B6264_21630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38747">
        <property type="protein sequence ID" value="OEV38747"/>
        <property type="gene ID" value="HS99_0018900"/>
    </dbReference>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV38747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="22978" checksum="396970740ADE9C4D" modified="2017-01-18" version="1">MLNKYARAFFTRVLTPFAAFLIRLGVSPDAVTLIGTAGSVAGALVFFPRGEFFWGTITITLFIFSDLVDGNMARQLGRSSKWGAFLDSTLDRVADAAIFGGLAMWYAGKGDNNLLCAVAIFCLASGLVVSYTKARAESQGLPCDVSGLVERAERLVISLVAAGVAGLHEFGVPYVEWLLPVALWLVAAGSLVTVFQRMLTVRREAFEADRAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI4</accession>
    <name>A0A1E7NDI4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="8" type="ORF">HS99_0019000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286373.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000458.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7351"/>
    <dbReference type="EnsemblBacteria" id="ARF81170">
        <property type="protein sequence ID" value="ARF81170"/>
        <property type="gene ID" value="B6264_21730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38762">
        <property type="protein sequence ID" value="OEV38762"/>
        <property type="gene ID" value="HS99_0019000"/>
    </dbReference>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="531"/>
            <end position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="596" mass="65682" checksum="27225466B8316DF0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDJ1</accession>
    <name>A0A1E7NDJ1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ORF">HS99_0020305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene617"/>
    <dbReference type="EnsemblBacteria" id="OEV38714">
        <property type="protein sequence ID" value="OEV38714"/>
        <property type="gene ID" value="HS99_0020305"/>
    </dbReference>
    <dbReference type="OMA" id="YVALVPW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="203"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="51437" checksum="E65A9C7E2E1EB250" modified="2017-01-18" version="1">MAAGAVPVVAFPAPGLAWLAWIALVPGLSLIQRAPSGREAAVRGWWFGAGFILTAMYWLVPSIGPALPVLAVLFGALQSVVGYAVHRLLHPPLTTRRALLALLVVPAAWVSTEYARSWHALGGPWALLGATQWQHPAILGLASAGGIWLVSAAVAAVNTGALIALTAVHWRPRAAAALVTVLVLAAGPLLFALRPAPAGAGAVTVALVQPGIVEDPQARFEASTRDTAALVGQPVDLVVWGESSTTADLDRDPAALDELRRLAATTGAEVMAGEDARKADGRISKDAVLVSPVGVVDRYRKIRLVPFGEYIPLRPVLGWIAGVSRAAGENRASGSDFHVLPATDRAGRPLPVGALICFESAFPDMARTAARDGARVLVYQSSTSTFQHTWAPEQHVSLAAIRAAETGRPAVQASLTGVSAAFDAQGRELARLGTDGTGALTVRLPLAAPGTLTWYDRIGDVVPMGALLVTAGAAVPAWRSRTAAGRAAAGPGTRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL9</accession>
    <name>A0A1E7NDL9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="6" type="ORF">HS99_0019155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290261.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7383"/>
    <dbReference type="EnsemblBacteria" id="ARF81198">
        <property type="protein sequence ID" value="ARF81198"/>
        <property type="gene ID" value="B6264_21890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38791">
        <property type="protein sequence ID" value="OEV38791"/>
        <property type="gene ID" value="HS99_0019155"/>
    </dbReference>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="330" mass="35694" checksum="A5ACA7512173516D" modified="2017-01-18" version="1">MKRHLVSAADLSRDDALLILDTAEELAQLSGRAVKKLPTLRGRTVVNLFFEDSTRTKTSFEVAEKRLSADVINFSAKGSSVSKGESLKDTALTLQAMGADAVVIRHHASGAPARLAQSDWLHGSVINAGDGTHEHPTQALLDAFTMRRHLNAGAGNDLAGRRVTIVGDVLHSRVARSNVHLLTTLGAQVTFVAPPTLLPIGIENWPCEVSYDLDSVLPKTDALMMLRVQRERMNAAFFPTEREYSRRYGMNGIRMAQLPEHAIVMHPGPMVRGMEITAEVADSPRCTVVEQVANGVSVRMAVLYLLLGGAVFADGPADTAPRTDSVENAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDQ6</accession>
    <name>A0A1E7NDQ6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0019440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5122"/>
    <dbReference type="EnsemblBacteria" id="OEV38841">
        <property type="protein sequence ID" value="OEV38841"/>
        <property type="gene ID" value="HS99_0019440"/>
    </dbReference>
    <dbReference type="OMA" id="LMAMIDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="924" mass="99404" checksum="2AA82E035BEF14ED" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE65</accession>
    <name>A0A1E7NE65_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6533"/>
    <dbReference type="EnsemblBacteria" id="OEV38935">
        <property type="protein sequence ID" value="OEV38935"/>
        <property type="gene ID" value="HS99_0019765"/>
    </dbReference>
    <dbReference type="OMA" id="AHRSGIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="36545" checksum="80F530DE91874794" modified="2017-01-18" version="1">MSHNHAGTPWPLVDLGQVPIRVHGAGVYYRRFFERDADHFHRIRAEHAFQSLTESTKPGSAHRSGIYLTPVTRTGDDELHFRLLRCSTNLSGPTENFGPTDTDIVDALNREAATVFRDHAPLNHVLAQTYHNTHATPERKQSKAKISSHADKTKDMPANGIMAFCTFYDRLDGLQPLAEDPFDYGTKNSSALTRLHFRLKDSAAELHGDTLPSHFSLTLYPGSVFFVPLSTNRLYTHEIRPSALDAELLPTRLGYVVRCSNTEAVHKDGRTFLKSAGDLVELEPPTQAGMDALRGLYAEENRSSSFVDYGNRFLFSMNTGDYLAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC5</accession>
    <name>A0A1E7NEC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557547.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1045"/>
    <dbReference type="EnsemblBacteria" id="ARF83253">
        <property type="protein sequence ID" value="ARF83253"/>
        <property type="gene ID" value="B6264_30400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39022">
        <property type="protein sequence ID" value="OEV39022"/>
        <property type="gene ID" value="HS99_0018130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9124" checksum="9A8986D50D7C3830" modified="2017-01-18" version="1">MPRTTMPVTGVHADGTACTHQVNQRTGRPKDSNSDCPGRTGYGATCSACGETVTNYLKLLVTPEVTKHLRQHTSTAPQAEPTGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEK6</accession>
    <name>A0A1E7NEK6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558240.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83370">
        <property type="protein sequence ID" value="ARF83370"/>
        <property type="gene ID" value="B6264_29970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39129">
        <property type="protein sequence ID" value="OEV39129"/>
        <property type="gene ID" value="HS99_0017715"/>
    </dbReference>
    <dbReference type="OMA" id="MQLYAIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="186" mass="19951" checksum="7990576644651E1A" modified="2017-01-18" version="1">MSVAVTEHSGPWTVEDVLALPEDTHHRIELVGGALLMSPNPGVPHQRASSRLWALLDAAITAASAPFEVLEAVNVIVPDGLLIPDLVVADAVAAAEAGTTLSAHDIVVAIEIASPSTRVADKKMKPSLYAAAGIPHYWRLELEPAPRLYLGHLERGLYVDRLIQVGETTALTDPFPLNIDPARLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEP1</accession>
    <name>A0A1E7NEP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0000070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285095.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3474"/>
    <dbReference type="EnsemblBacteria" id="OEV39167">
        <property type="protein sequence ID" value="OEV39167"/>
        <property type="gene ID" value="HS99_0000070"/>
    </dbReference>
    <dbReference type="OMA" id="EHGLAWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32095" checksum="3D74CD8D9F581C18" modified="2017-01-18" version="1">MPTAPHTARRSRWGEHGLAWAFLLPSLVVFALFIGYPLGRTIYLSGHANDLFGAPSRYVGAKHYTDLLSSADFGRTLVTTGLFTLLTVVPGVLGALVLVLLLENRIRGVRLLRSAFALPFAFSVASASVVFAVFFNPASGVLNGLLSHVGLGPVGWLTDSRYALVSVALTTVWMNLGYNVLVLSAGIASIPGEIVEAARIDGASGLRLSRSITVPMLGPNLFFLTVVSTVHALQSFGQIHILTKGGPDGSTRTLVYSVYEKAFAYNSSDFGTASAQAVVLLVVVLACTAVQFGVLERKVHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV7</accession>
    <name>A0A1E7NEV7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285232.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3547"/>
    <dbReference type="EnsemblBacteria" id="OEV39227">
        <property type="protein sequence ID" value="OEV39227"/>
        <property type="gene ID" value="HS99_0000420"/>
    </dbReference>
    <dbReference type="OMA" id="NGFLFNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="159"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="35818" checksum="608F1DE659C06BE8" modified="2017-01-18" version="1">MLAYAPAALFFLLCGIGVLRDRRRFSNAVLLGIAVSLLALALLTELRRAPTLVAELAAVAIILLPTIGTVALVWFLLANGVTMIRKEGRRPANLLSLLAGLGIIAVIALLVAAIATRSPRLGILAGTAVLVVGYVSFLFVCFVGYAFLYGRHRPRGDVDFVVVLGSGLIGGERVPPLLASRLIRGREVYERQAARGNPPVLITSGGQGPDEKLPESDAMAAYLIERGFPAQHIEREDRSRTTEENLLFSRAIMERAKPDYRCVVVTNNFHAFRAALTARKTGVNGHVFGSPTARYYWPSATIREFAAIFLSHKLVNFGICGLLALCGVLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX6</accession>
    <name>A0A1E7NEX6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366990.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000410.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39198">
        <property type="protein sequence ID" value="OEV39198"/>
        <property type="gene ID" value="HS99_0000245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="21793" checksum="204883D057A387EE" modified="2017-01-18" version="1">MIEPPRIGISPVIASVTESWTFIDAWLAEHAPASLAELQLPASPEAISRAEERLGFPIPADLRESLLCHNGDGSSVGVLPCGPMYSTERIVEIRDMRMRIWDADDPDQQDDPWWGMLWVPFAGGDGDEHFIHAGPGLWHNHLGRAPHDDSAYFVGWPSLAAWLHGITQAMAHYDDRDWSGTAYRPMLRKDGTVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF42</accession>
    <name>A0A1E7NF42_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HS99_0000985</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3665"/>
    <dbReference type="EnsemblBacteria" id="OEV39320">
        <property type="protein sequence ID" value="OEV39320"/>
        <property type="gene ID" value="HS99_0000985"/>
    </dbReference>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="39"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="213"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV39320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="40875" checksum="72F394AA6A57D330" modified="2017-01-18" version="1">MHRTATKLADGRELVYFDRAPGAVRDVRDERPLEPAASLSEIRLDPVLGEWVTVAAHRQQRTYRPPAGECPLCPSRDGRHSEIPAADYEVAVFENRFPSLAPAAAEHVASRDEPLHTLRPGDGRCEVVCFTSDHDASFADLDETRARLVLDAWTDRTAELSALPGVRQVYCFENRGEEIGVTLAHPHGQIYAFPFVPSRTARMIARAEAHRARTGRNLFEDLLAAEQATPERLVLQGEHWLAFVPFAARWPYEVHLYPRRRVADLTALTEPERAEFPGLYLDLLRRFDALFPAPPGAGPNRTPYISAWHQAPRTDGGQLALHLELFTVRRAPGKLKYLAGVESGMDAFVTDVSPEQAAARLREAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF70</accession>
    <name>A0A1E7NF70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556001.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1520"/>
    <dbReference type="EnsemblBacteria" id="OEV39351">
        <property type="protein sequence ID" value="OEV39351"/>
        <property type="gene ID" value="HS99_0001160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11084" checksum="444488619C690041" modified="2017-01-18" version="1">MSGGDNGGVGVGFSAHPEKLGDAGDQLIAASTDVGSVKDALGKLGMSGEDTFGEYGASDAAKAFWQAWQDELGVNVDALNDLGGKVHTTAANYTNTDHGVGQQYQHQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFG3</accession>
    <name>A0A1E7NFG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558135.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene551"/>
    <dbReference type="EnsemblBacteria" id="OEV39412">
        <property type="protein sequence ID" value="OEV39412"/>
        <property type="gene ID" value="HS99_0001550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="8017" checksum="3F4CEA3E8FD238EC" modified="2017-01-18" version="1">MLNTSLNQTCVAELSRSDGLTYTFRASWGAAKTTFLPDTGYTMWICVWNANNRSAEQCSARFAMNGTTPTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG42</accession>
    <name>A0A1E7NG42_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385774.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2790"/>
    <dbReference type="EnsemblBacteria" id="OEV39647">
        <property type="protein sequence ID" value="OEV39647"/>
        <property type="gene ID" value="HS99_0002980"/>
    </dbReference>
    <dbReference type="OMA" id="ILYHQQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199116" evidence="1">
        <location>
            <begin position="17"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="556" mass="59027" checksum="6651D6B12A3B3773" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG98</accession>
    <name>A0A1E7NG98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550466.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39730">
        <property type="protein sequence ID" value="OEV39730"/>
        <property type="gene ID" value="HS99_0003475"/>
    </dbReference>
    <dbReference type="OMA" id="PDYQAPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="23982" checksum="99A7CEFE627D8E6F" modified="2017-01-18" version="1">MARRPNKKQKRPLAAGAGRSPKPARRRSGKDIRLAPRTVRRTALLVGLLAPLLIVGLLALATNPDYQAPCTVLAVLVLMAAVVGLMMIRSTGWVIWPAVLLGVLLLVIPTAALRAQLIAHRGVDTRVVITSAHSGKDRMGKVSWTCGIRREDGQPLPHGSVVGTGCSGGSVGRTTTVLADPDGWAPPATLDDDLSFRGAGVYVAGAAAVLWAALTFGAARRSLGGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK9</accession>
    <name>A0A1E7NGK9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">HS99_0000395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550164.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3542"/>
    <dbReference type="EnsemblBacteria" id="OEV39788">
        <property type="protein sequence ID" value="OEV39788"/>
        <property type="gene ID" value="HS99_0000395"/>
    </dbReference>
    <dbReference type="OMA" id="CPPTFCT"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="30475" checksum="96B2E18A9621E41B" modified="2017-01-18" version="1">MTQDAVPATETVRADWAGIDRLPTLDLLHLMNAEDRTVPAAVAGQLAAIAAVVDAAAARMARGGRLVYAGAGTAGRLGVLDAAECPPTFGTDPGLVVGLIAGGRTAVTEAVEGAEDRTDLAEADVAALGLTPADTLVGVSASGRTPYPLAAVRAARAAGALTVGLACNRGSALAAAADLGIEVEVGPEVLAGSTRLKAGTAQKLVLNLLSTAVMVRLGRTYGNLMVDLRATNAKLRDRARRIVAEATGADEEAVRRALAATDGRAKDAVLVLLADVDAPTAARLLAATAGRLRDALELPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL2</accession>
    <name>A0A1E7NGL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550305.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39603">
        <property type="protein sequence ID" value="OEV39603"/>
        <property type="gene ID" value="HS99_0002715"/>
    </dbReference>
    <dbReference type="OMA" id="VYLCHPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="28583" checksum="AB32161487B51BBE" modified="2017-01-18" version="1">MDDTTLISSFLRDGFVKLEGAVAPRVAADCARLLWRETGCDPDDPSTWTQPVHWVAGMAQGPFAAAPNSLSLHRAYDLLVGGGRWEPRYSLGSFPLRFPHQEEPDDAGWHIEGSYLPEGENRYFTNLRSKGRALLMLFLFSEVGEDDAPTRIRVGSHLDVPKVLAQYGEEGASGLTLAPDLVAASEHRPIALATGSPGDVFLCHPFLVHAAQPHHGLRPRFMAQPPLMPAEPYELERADGAYSPVETAIRQGLGRDTPGHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGL3</accession>
    <name>A0A1E7NGL3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0002985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2791"/>
    <dbReference type="EnsemblBacteria" id="OEV39859">
        <property type="protein sequence ID" value="OEV39859"/>
        <property type="gene ID" value="HS99_0002985"/>
    </dbReference>
    <dbReference type="OMA" id="NMTEFRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006584">
        <property type="entry name" value="Cellulose-bd_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03422">
        <property type="entry name" value="CBM_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00606">
        <property type="entry name" value="CBD_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="SSF50405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="5">
        <location>
            <begin position="723"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="CBD_IV" evidence="4">
        <location>
            <begin position="812"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="942" mass="101931" checksum="94452C10749F2A9F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGV3</accession>
    <name>A0A1E7NGV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550430.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000984.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2843"/>
    <dbReference type="EnsemblBacteria" id="OEV39693">
        <property type="protein sequence ID" value="OEV39693"/>
        <property type="gene ID" value="HS99_0003245"/>
    </dbReference>
    <dbReference type="OMA" id="WGADQHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="145"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="27922" checksum="40EA00C333C93065" modified="2017-01-18" version="1">MTPLDHGTAVAAETARFVAAVRQADPALPVPGCPGWTLADLVRHTGSVQRWFTVLLRQRIQEPPRSRDVDLRLPERPEDYPAWLAEAAEQAAAAFAEGDLDAPMWAWGADQHARFWVRRMLFETLVHRVDAERALGLEPEIDPALAADGVDEFLTNLPFAAFFAPATAELRAENRTVRFARTDGEGDWLVRLRPDGFGLDHADTDTEADATVRATAAELLLMLYGRLDRDTAGVELSGDQELLAHWFAHSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV52</accession>
    <name>A0A1E7MV52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000131.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6887"/>
    <dbReference type="EnsemblBacteria" id="OEV32307">
        <property type="protein sequence ID" value="OEV32307"/>
        <property type="gene ID" value="HS99_0016500"/>
    </dbReference>
    <dbReference type="OMA" id="LAFWRAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="4">
        <location>
            <begin position="137"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="614" mass="62541" checksum="DC20519A4A5DBE97" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD5</accession>
    <name>A0A1E7MVD5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32385">
        <property type="protein sequence ID" value="OEV32385"/>
        <property type="gene ID" value="HS99_0016960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="12018" checksum="03667F38E3B02446" modified="2017-01-18" version="1">MVAQTAPIRIERLMPREAEPRDRVASIELLASPQVHSYLGRPRSRDELEGELPEVPERWPGRLPGDDRLRGRQARPSPGSGACDRPWRSPTGRVWAMVFRLIVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW28</accession>
    <name>A0A1E7MW28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553389.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3859"/>
    <dbReference type="EnsemblBacteria" id="ARF78322">
        <property type="protein sequence ID" value="ARF78322"/>
        <property type="gene ID" value="B6264_04785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32636">
        <property type="protein sequence ID" value="OEV32636"/>
        <property type="gene ID" value="HS99_0015295"/>
    </dbReference>
    <dbReference type="OMA" id="DFVLLWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="39689" checksum="398B2F6AEC86026D" modified="2017-01-18" version="1">MTKSTAKAPLAGTPSLLRAINDRAALELLLENGPLSRTQIGALTGLSKPTASQLLSRLEAAGLVVPVGTTEGGPGPNAQLYQVNPAAGYVAGLDVTNSGIRVAVADITGSTVAEHSVSTRGVPAAGTVPGVAAAVAEAVRAAGVPAGGLRTVAIGVGGAPDPVTGKLRYASHLPGWHSPRLVAELTEAIGAPVSIENDVNLAAVAEQASGAAAGFEDFVLLWAEAGVGAAIVLGGRLHRGFTGGAGEVGYMPVPGSPVEWDARRRKFGGFQAQVGAPAVRTLAREHGLGAPSAEESIAKALETPGAGDAFLTELAGRLAVGLSVIVAVVDPQLVVLSGAVPSAGGERLRALVEDELARICLARPEIRSSALPGSPVLLGALQRALTDAREAVFSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW49</accession>
    <name>A0A1E7MW49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288246.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000121.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3150"/>
    <dbReference type="EnsemblBacteria" id="ARF78300">
        <property type="protein sequence ID" value="ARF78300"/>
        <property type="gene ID" value="B6264_04650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32662">
        <property type="protein sequence ID" value="OEV32662"/>
        <property type="gene ID" value="HS99_0015435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="267" mass="28833" checksum="78BDB755A5870D97" modified="2017-01-18" version="1">MEILLQVLIASVPAVMGFLAARSLARTRLLLRYGFLRALLAPYGRVQIVIPSLEVAEFAFTEDGCQLTSRGPKNVLFVPMAEARAIAELTDLLRKINRKATIELVVAGAQDPRMPTFSIGGPSVNSYSGGVLEAVFPDFTIEYPDEARARWGGMTFESLYGPAGELIRDHGFIFVTHTPRHAPCVVLCGVFAFGSAMAVEALTSANRNSSLAALFRSGEKGFVAVEGRVIGLDTVDVTVEVCRVLPAPRSDVPPGFRGEVPISRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW63</accession>
    <name>A0A1E7MW63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480451.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2971"/>
    <dbReference type="EnsemblBacteria" id="OEV32503">
        <property type="protein sequence ID" value="OEV32503"/>
        <property type="gene ID" value="HS99_0016245"/>
    </dbReference>
    <dbReference type="OMA" id="ECPKGVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="9"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="35067" checksum="5FDEC9A9C2903755" modified="2017-01-18" version="1">MRLARRPVGEVRPEDWEYGEEPVGVPGDGEFLGRTRYLSLDPAMRGWLDDRPSYLPPVGLGDVMRAGSVVEVVASNHPKFQVGDHVVGTFGVQDYAVSNGKGALKVDPALAPLSTYVGALGMPGMTAYFGLLEVGALKEGETVVVSGAAGAVGTMVGQIAKVKGCRVVGIAGGPRKCALLTEELGFDAAIDYRSEDVRKALRTHAPDGIDVYFDNVGGPILDAALTRLAMHARVVVCGAISQYNNEDAVQGPSNYLSLLVRRARMEGFVVFDYARRYAQAAAEIAGWIGEGRIKVKEHVVEGTVADFPETFGMLFRGENTGKLVLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW99</accession>
    <name>A0A1E7MW99_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0015745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290221.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000836.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7857"/>
    <dbReference type="EnsemblBacteria" id="ARF78248">
        <property type="protein sequence ID" value="ARF78248"/>
        <property type="gene ID" value="B6264_04340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32712">
        <property type="protein sequence ID" value="OEV32712"/>
        <property type="gene ID" value="HS99_0015745"/>
    </dbReference>
    <dbReference type="OMA" id="WKPSPFA"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="542" mass="58543" checksum="D315D059E63E376A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWH4</accession>
    <name>A0A1E7MWH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287864.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82629">
        <property type="protein sequence ID" value="ARF82629"/>
        <property type="gene ID" value="B6264_04820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32787">
        <property type="protein sequence ID" value="OEV32787"/>
        <property type="gene ID" value="HS99_0015260"/>
    </dbReference>
    <dbReference type="OMA" id="GYENADK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="367" mass="37146" checksum="B05651C66A13572E" modified="2017-01-18" version="1">MSPTSRRARVRALTGLSALALAAAGFAAAPAAQADQPGSEFAGQSHPYRHGVVPTKESAEHANANSAAATRTSNLRYGGGVDGIGVTTGAPKVYVVFWGSQWGTAGTDANGYTTLTGDPSGEAVRAQQLYKGLGTNNETWSGVMTQYCQGVATGATSCGSTAAHVGYPTGGALAGVWVDNSAAAPGQATGNQIANEAIKAAGHFGNTTSAANRNVQYVVLSPTGTHPDGFNTSSGNFCAWHDWNGDTTLTGGAATSPYGDIAFSNDPYVTDMGTSCGQNYVNSGNAGLLDGVTMVFGHEYAETVTDQNPAGGWTDSTGYENADKCAWKGVGGTGGSQNVAFATGSFAMQGTWSNAVSGCQISHAIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI0</accession>
    <name>A0A1E7MWI0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0015320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3863"/>
    <dbReference type="EnsemblBacteria" id="ARF82627">
        <property type="protein sequence ID" value="ARF82627"/>
        <property type="gene ID" value="B6264_04760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32790">
        <property type="protein sequence ID" value="OEV32790"/>
        <property type="gene ID" value="HS99_0015320"/>
    </dbReference>
    <dbReference type="OMA" id="QYPNWRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="694" mass="75665" checksum="79E9920835EF40BB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX14</accession>
    <name>A0A1E7MX14_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386889.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000556.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5749"/>
    <dbReference type="EnsemblBacteria" id="ARF81374">
        <property type="protein sequence ID" value="ARF81374"/>
        <property type="gene ID" value="B6264_22885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32961">
        <property type="protein sequence ID" value="OEV32961"/>
        <property type="gene ID" value="HS99_0013855"/>
    </dbReference>
    <dbReference type="OMA" id="PAYSTWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="580" mass="61680" checksum="CC19C94B85F12939" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK6</accession>
    <name>A0A1E7MXK6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3419"/>
    <dbReference type="EnsemblBacteria" id="OEV33172">
        <property type="protein sequence ID" value="OEV33172"/>
        <property type="gene ID" value="HS99_0014720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="36259" checksum="A90973A709E96ED7" modified="2017-01-18" version="1">MAPEEGERRTRRRGGFATRAEAAREMKAVLDGELRGVYEDRRTTVASFLRQWLATKKEELAPNTYAGYEARVERDLIPAFGHYRLPDLRPQHIERWIAAQRKAKRGKVTVYRIVSTLRNALNAAVRAWGLRYNPAKHSVPPRPRAAERICWPPEQAAAFLQQGVEQYADQLTDLFEVMLGTGMRRGEVLTLHWSDVHLMDRKLFVRWTLAAIDNGKIHLREPKTEAGRAWISLSPRVMAALHRQAAIQKRHTAASIMIAENIPIAVISKTLRHSTIATTINLYGHLLKDSADQAVLALAQALDRAAAGQSPVPGPGEVLRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY23</accession>
    <name>A0A1E7MY23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0012100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737964.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000587.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7042"/>
    <dbReference type="EnsemblBacteria" id="ARF80433">
        <property type="protein sequence ID" value="ARF80433"/>
        <property type="gene ID" value="B6264_17330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33332">
        <property type="protein sequence ID" value="OEV33332"/>
        <property type="gene ID" value="HS99_0012100"/>
    </dbReference>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="865" mass="89070" checksum="FC86D1053534BD18" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY66</accession>
    <name>A0A1E7MY66_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name evidence="2" type="ORF">HS99_0012200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283907.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3393"/>
    <dbReference type="EnsemblBacteria" id="ARF80452">
        <property type="protein sequence ID" value="ARF80452"/>
        <property type="gene ID" value="B6264_17430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33351">
        <property type="protein sequence ID" value="OEV33351"/>
        <property type="gene ID" value="HS99_0012200"/>
    </dbReference>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="1">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="40292" checksum="66BC948268AF4043" modified="2017-01-18" version="1">MATDYYAVLGVRRDAGQDEIKKAFRRLARELHPDVNPDPKTQERFKEINAAYEVLSDPQKRQVYDLGGDPLSPGGGGGAGGFGAGAAGFGFSDIMDAFFGAAAGQRGPRSRTRRGQDAMIRLEITLEEAAFGTTKELQVDTAVTCTTCNGEGAAPGTSAQTCDMCRGKGEVSQVTRSFLGQVMTSRPCPQCQGFGTVVPTPCPECAGDGRVRARRTLTVKIPAGVDNGTRIQLAGEGEVGPGGGPAGDLYVEIAETAHSVFQRRGDDLHCTVTIPMTAAALGTQVPLQTLDGLEEVDIRPGTQSGQSIPLHGRGITHLRGGGRGDLIVHVEVQTPTKLDAEQEELLRRLSMLRGEERPSGQFAPGQQGLFSRLKDAFNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYH8</accession>
    <name>A0A1E7MYH8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ORF">HS99_0012940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6613"/>
    <dbReference type="EnsemblBacteria" id="OEV33471">
        <property type="protein sequence ID" value="OEV33471"/>
        <property type="gene ID" value="HS99_0012940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18095" checksum="2E97496A0B9022F0" modified="2017-01-18" version="1">MHFELGPLGPDPGMLVLGLAQLFLLMFALGVVLLPRIERMRAQRWDATEGRTERAEAVRAEAEATRDAALDEIAGARHEAARIRQEYAERGAAAIAAARAEGTRDRDRLLTTGRARIAAGRSAAADRLRQDVGDLAVALAGRVVGEPVHAVAAERRTVERFLARPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYN0</accession>
    <name>A0A1E7MYN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282611.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5219"/>
    <dbReference type="EnsemblBacteria" id="ARF80641">
        <property type="protein sequence ID" value="ARF80641"/>
        <property type="gene ID" value="B6264_18575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33538">
        <property type="protein sequence ID" value="OEV33538"/>
        <property type="gene ID" value="HS99_0013355"/>
    </dbReference>
    <dbReference type="OMA" id="KNWTSRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="34746" checksum="CD36D70B092670AE" modified="2017-01-18" version="1">MSTIQHTTHSIDVDAPAEVVYTVIADALAWPRRFAPTLHVEREELGPGAERLRIWARANGEVKHWTSRRDLDADLRRIRFRQEASSAPVASMAGEWQVAERPGGTTLTLTHEFSALDDDPQGLRWISEATDRNSRSELAGIKDLAERWNRLAEFEFEFEDSVLVDAAPEAVYDFLRDAAAWPARLPHVARLDLREEAGGIQHMSMDTRTADGSEHTTESIRICFPESGIAYKQLRTPSMMAAHTGRWTVESTDRGVRVTSWHAVVLNPEAVPTVLGPDATAATARRFIREAAGGNSRATLGLAKRFAEERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ3</accession>
    <name>A0A1E7MYQ3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neutral metalloproteinase</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0012275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553480.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80465">
        <property type="protein sequence ID" value="ARF80465"/>
        <property type="gene ID" value="B6264_17505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33363">
        <property type="protein sequence ID" value="OEV33363"/>
        <property type="gene ID" value="HS99_0012275"/>
    </dbReference>
    <dbReference type="OMA" id="FCTIVPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M4" evidence="7">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="8">
        <location>
            <begin position="168"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="35874" checksum="FD173F18FE057709" modified="2017-01-18" version="1">MNAAVPICAIVPPYVLDRLAEAGHEPAVRSLALDTAHRAARLTAPPPTAGARGLNRVIADTGHSQRLPGRTVRTEGHAPVADPSVNHAYDGLGDTFALYAQVFGRDSIDGRGLRLDASVHYGQNYENAFWNGRRMVFGDGDGRIFGDFTACVDVIGHELTHGVTQFTAGLEYQDQPGALNESVSDVFGSLVKQYALHQSAADADWLIGAGLLAPGIQGVALRSMKAPGTAYDDPQLGKDPQPAHMRDYVNTTQDNGGVHINSGIPNHAFYLLATALGGQAWDRAGRIWYDALTGGGLSADADFTAFARATVAAAKARYPDRSSIADTVSASWAQVGVSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU9</accession>
    <name>A0A1E7MYU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737966.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3971"/>
    <dbReference type="EnsemblBacteria" id="ARF80517">
        <property type="protein sequence ID" value="ARF80517"/>
        <property type="gene ID" value="B6264_17820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33413">
        <property type="protein sequence ID" value="OEV33413"/>
        <property type="gene ID" value="HS99_0012595"/>
    </dbReference>
    <dbReference type="OMA" id="MPHIDRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18663" checksum="3DE137FD85F245B5" modified="2017-01-18" version="1">MATPVRAQAGLRSCAEVFNHPVGDADRTARHTISEVAAASGLTAHTLRWYERIGLLDPVDRAVGGQRRYSDGDLHRLAFLGRLRLTGMSVADMLKYVDMVRRGEQTYVERRHLLEAQREEVRQRIVDLQATLAVLDHKIDLYAGMIADAAGAPAQCQYYRAEEEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ05</accession>
    <name>A0A1E7MZ05_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="5" type="ORF">HS99_0038425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280912.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000303.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4932"/>
    <dbReference type="EnsemblBacteria" id="ARF80001">
        <property type="protein sequence ID" value="ARF80001"/>
        <property type="gene ID" value="B6264_14755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33664">
        <property type="protein sequence ID" value="OEV33664"/>
        <property type="gene ID" value="HS99_0038425"/>
    </dbReference>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="30046" checksum="3CFC497F24AF8174" modified="2017-01-18" version="1">MAIFLTKDSKVIVQGMTGAEGMKHTRRMLASGTQIVGGVNPRKAGTTVDVDGTEIPVFGSVAEAMEKTGADVSVLFVPPAFTKAAVVEAIDAEIPLAVVITEGVPVHDTAAFWAYAGSKGNKTRIIGPNCPGLISPGQSNAGIIPADITTSGKIGLVSKSGTLTYQLMYELRDIGFSSAVGIGGDPVIGTTHIDALKAFQEDPETEIIVMIGEIGGDAEERAAAYIAEHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAQAKKEALEAAGVKVGKTPSETARLAREIIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ56</accession>
    <name>A0A1E7MZ56_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0037980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288049.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7711"/>
    <dbReference type="EnsemblBacteria" id="ARF78577">
        <property type="protein sequence ID" value="ARF78577"/>
        <property type="gene ID" value="B6264_06295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33735">
        <property type="protein sequence ID" value="OEV33735"/>
        <property type="gene ID" value="HS99_0037980"/>
    </dbReference>
    <dbReference type="OMA" id="AQFKAVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="23957" checksum="18DBA25677E646AE" modified="2017-01-18" version="1">MNKAQLVEAVAEQLGGRKAAAEAVDAVLDTMVRAVVAGDRVSVTGFGTFEKVERSARFARNPQTGERVKVKKTSVPRFRPGQGFKDLVSGSKKLPKEGPSVKKAPKGSLTPGKTGVAATPAAKRAATKRAATAAAAAPAATKKTAAKKATTTAAAKKTTATAAKKAPAAKKATTTAAAKKTTATATKKTAAAKKATTTAAAKKTTATAKKATATAKKTAPAKKTATRKTTARKTSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ57</accession>
    <name>A0A1E7MZ57_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551939.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79621">
        <property type="protein sequence ID" value="ARF79621"/>
        <property type="gene ID" value="B6264_12500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33718">
        <property type="protein sequence ID" value="OEV33718"/>
        <property type="gene ID" value="HS99_0038235"/>
    </dbReference>
    <dbReference type="OMA" id="YRWILET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="9762" checksum="742D0D8733D43FBF" modified="2017-01-18" version="1">MRRYRWILETQNDDGRWSRQDDTTMPNPLEYDGPPQRAANHLRDVFVRTLSRPAPGPRAVRVRLWEGTGIDGEPQAETEWSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI2</accession>
    <name>A0A1E7MZI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290404.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000268.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4406"/>
    <dbReference type="EnsemblBacteria" id="ARF80323">
        <property type="protein sequence ID" value="ARF80323"/>
        <property type="gene ID" value="B6264_16675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33837">
        <property type="protein sequence ID" value="OEV33837"/>
        <property type="gene ID" value="HS99_0037495"/>
    </dbReference>
    <dbReference type="OMA" id="DWVVWSA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="22397" checksum="0CA9807F4683B2F3" modified="2017-01-18" version="1">MRTVIAGGHGQIALKLERLLADRGDRPAGIIRRPEQAQDLVDAGAEPLVLDLESATAPQLAALLADTDAVVFAAGAGPGSGAARKNTVDRDAAVLLADAAELAGVRRYLMVSSMGADAAAHHPDEVFETYLRAKGAADDAVRSRTTLDWTVLRPGSLTDGTGTGLVRLAPSVGRGTVDRADVAAVLAALLREPGTAGQTLELVAGNATVAEAVAAAAGHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN3</accession>
    <name>A0A1E7MZN3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1829"/>
    <dbReference type="EnsemblBacteria" id="OEV33896">
        <property type="protein sequence ID" value="OEV33896"/>
        <property type="gene ID" value="HS99_0010455"/>
    </dbReference>
    <dbReference type="OMA" id="PAITCGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8205" checksum="E4042F64E53BD156" modified="2017-01-18" version="1">MPAIQCGVGATGRRIDRHLAVLGAPALSAVDTAEALGLIRELTPRGAGTPAAARRRHTRVSLLAPLRRLRRSLFGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN8</accession>
    <name>A0A1E7MZN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283067.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1833"/>
    <dbReference type="EnsemblBacteria" id="ARF77743">
        <property type="protein sequence ID" value="ARF77743"/>
        <property type="gene ID" value="B6264_01315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33900">
        <property type="protein sequence ID" value="OEV33900"/>
        <property type="gene ID" value="HS99_0010475"/>
    </dbReference>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="611" mass="66020" checksum="E5C24B29352B4C3F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP7</accession>
    <name>A0A1E7MZP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366454.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000311.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1851"/>
    <dbReference type="EnsemblBacteria" id="ARF77759">
        <property type="protein sequence ID" value="ARF77759"/>
        <property type="gene ID" value="B6264_01405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33917">
        <property type="protein sequence ID" value="OEV33917"/>
        <property type="gene ID" value="HS99_0010565"/>
    </dbReference>
    <dbReference type="OMA" id="ARKSGHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="31942" checksum="240D2BD1A7BD3479" modified="2017-01-18" version="1">MPNQGNSRTGRAVGGVRELIAEALAERTPGGVRPGELDRGGRALRWVETGPGEGVPIVLVAGCGESSLTWAPLLPELAELGRVVAYDRAGLGASAPDRAPRLTLDAQVEDLAALVRYLDAGPAVLVGHSWGGQLAQLLARQRPELVAGLVLVDPAHEEFSPRAIALAEVALLRFSLLRTAIAPTAPDRGDALARAGAAAVARPYQRRAVLAEHRLTGRAVPALRRRRAAAPLPEVPVTVLSATEGLPRSLRARFTAAQAGIAAGADRGVHTVVPGAGHYVHADRPHVVAAAVREVSAPARIARNAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZQ9</accession>
    <name>A0A1E7MZQ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283132.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000288.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77775">
        <property type="protein sequence ID" value="ARF77775"/>
        <property type="gene ID" value="B6264_01500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33928">
        <property type="protein sequence ID" value="OEV33928"/>
        <property type="gene ID" value="HS99_0010660"/>
    </dbReference>
    <dbReference type="OMA" id="LVARMRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33871" checksum="9C97B47BF2C64E82" modified="2017-01-18" version="1">MIAYEDHSLRALAEDGRWPELLAAYRQGRAAAVVQAGEQAAVALTAPLGHLIAYAAPPELAVRLFDADGGEGTVAGVDDHDAGPLWEVLATRHSWLRLAPLLGPAPVRRLVAHTRVLLGEDLSYGAEPDPDGVPLSLEPWEKAGWGEASRVREYLPGGGARSAVLTLPASREGLGEVELPKAAARPGRQRVTRGLAELAALVPWAEVVCVRGPAPQAAAVLARGRRVLGGFLPFALVYPALVQAAAVGRTHGCAHGRMRLWRALGAMAGANVPDRSEVDALVARMRCFTWQEPAAGLHHLHVALEDPASGVAWAVSGSQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZT9</accession>
    <name>A0A1E7MZT9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366464.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000164.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2167"/>
    <dbReference type="EnsemblBacteria" id="ARF77800">
        <property type="protein sequence ID" value="ARF77800"/>
        <property type="gene ID" value="B6264_01650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33946">
        <property type="protein sequence ID" value="OEV33946"/>
        <property type="gene ID" value="HS99_0010810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="30149" checksum="1EF18EB72679E61A" modified="2017-01-18" version="1">MRTGLLGWHGPDHRPWVDSLLLLGILVLTAEEGLFQWLHADGPLRPYRIVVAALSALSLLFARRHPAASAVLPVLTSSLFNRAFPGLFGVAPLASLGRTGPAVAAGAVIVLASAARADSLVGWAGTTGSQLLLQVAVLSFGLWLHGRRALIRALHAQVENLRRERELRAEQARSAERARIAREMHDVLAHRLSLLVLHAGVAHPARARPGAGPVRPLVGLGERVGALGGHLDAGPDAVGGFRLSARLPAPDRPRPSRPTAARSESPGPRAPHPQPSQPPQPEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E4</accession>
    <name>A0A1E7N0E4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2156"/>
    <dbReference type="EnsemblBacteria" id="ARF82553">
        <property type="protein sequence ID" value="ARF82553"/>
        <property type="gene ID" value="B6264_01595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34152">
        <property type="protein sequence ID" value="OEV34152"/>
        <property type="gene ID" value="HS99_0010755"/>
    </dbReference>
    <dbReference type="OMA" id="RCVLAHY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="16260" checksum="C90D9D5C384BAEC0" modified="2017-01-18" version="1">MGRIELGLEGVRAAQHGRTAEARASFEALWEELGERDVFHRCVLAHYLADLQDDPRAELEWDRRALAAADSLTAERAATYESALQVRAFYPSLHLNLASDHLKLGEPDLAREQLERAVRSLDALPVDAYSAGIRAAVDELRQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Z3</accession>
    <name>A0A1E7N0Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283364.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3908"/>
    <dbReference type="EnsemblBacteria" id="OEV34359">
        <property type="protein sequence ID" value="OEV34359"/>
        <property type="gene ID" value="HS99_0036150"/>
    </dbReference>
    <dbReference type="OMA" id="STVMPTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="26420" checksum="EDDA69722DC3F33C" modified="2017-01-18" version="1">MDALNGRIALVTGGGSGLGRASSLALLEAGWTVVLAGRRKDALEETAALADVDPARVLTVPTDIRSPEEVARLFDAVRDRYGRLDLLFNNAGAAAPRRPITETPFGDWNRVLDTIATGSFLCAREAFRLMSTQTPQGGRIINNGAPSAHVPRPNSPAYTAAKHAVLGLTKVLALDGRPYGISCGQIDVGNIAPPDGSPQPAAMQADGTMAVEATIPVDRFTEALLLMASQPPDTSIQSLVVLPTTMPFVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N126</accession>
    <name>A0A1E7N126_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557810.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7200"/>
    <dbReference type="EnsemblBacteria" id="OEV34398">
        <property type="protein sequence ID" value="OEV34398"/>
        <property type="gene ID" value="HS99_0035900"/>
    </dbReference>
    <dbReference type="OMA" id="CGFAFTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="46340" checksum="447148D264B09ED9" modified="2017-01-18" version="1">MGSPSGGGPGVWLGRATVRTAADAPGTGPRTGDTRTIPGPRGRRAHRLLPGPGGASPPPTATSAPTRDGPPGAPPGRGRSMALSSVTTTAVLVLVGCGVLVLHLVQRQTGTVGLLVGLGLALVPLPFVLGGLAWLNLTARVPLRHTVFCLGWGACAATTVAILANNWTADYLTAHRGAFGGLLGAGIATPVIEESAKATALLVLLLPFGQRLRCHGRRSGRPCAPLLHRAPAPRRTHPPRRPPTGPHARGRLRLRPYLRPLPYLCPAPPSPGTPHRRSRPRTLAAGVVLGGMTACGFAFTENALYLGRAFTTDQRNRLDSIGLGDPPSLRDFDSTVQTFVLRALLSPFAHPLFTALTGIGLAVTLTTGRRWLARLAAPAGLLTAMVLHGTWNAAADLGTDGFLVVYGVLMVPCFVALVCFALWARSRAARHAWRRGRRSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N149</accession>
    <name>A0A1E7N149_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557824.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7210"/>
    <dbReference type="EnsemblBacteria" id="ARF79225">
        <property type="protein sequence ID" value="ARF79225"/>
        <property type="gene ID" value="B6264_10135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34406">
        <property type="protein sequence ID" value="OEV34406"/>
        <property type="gene ID" value="HS99_0035955"/>
    </dbReference>
    <dbReference type="OMA" id="IHETNQI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20397" checksum="05EAAED916FD3441" modified="2017-01-18" version="1">MPRVGLTPDQVVDHALALIDDQGTEALTLASVAARAGVATPSLYKHVSGGLTELRRLIAVRVTEELADRLAEAAVGRSGDDAVTALLRAYQAYATAHPHRYAALPQAPQPDEDLTKAATRLVGVIIAVLRGYGLDGPEVIHAARTVRSLAHGFAALSITGAFQLTEDLTTTHNRLITTLITGLHSWPKSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I4</accession>
    <name>A0A1E7N1I4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386365.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000333.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5590"/>
    <dbReference type="EnsemblBacteria" id="ARF79329">
        <property type="protein sequence ID" value="ARF79329"/>
        <property type="gene ID" value="B6264_10715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34542">
        <property type="protein sequence ID" value="OEV34542"/>
        <property type="gene ID" value="HS99_0035195"/>
    </dbReference>
    <dbReference type="OMA" id="PICDGYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="34606" checksum="8D66E5A42D0A0E3B" modified="2017-01-18" version="1">MSATKTAEYYDTAERHDAVVIGAGAAGLSAALVLGRARRRVAVVDAGEPRNAPAAHMQGFLSRDGMPPAALLAVGREEVARYGVDLIDGRVEHVENAEPTGLGFLVHLAGGPVLQARRVVVATGLRDGLPELPGLAERWGRDVLHCPYCHGWEVRDRPLGVLGTAPGSVDQALLLRQWSADVVLLAHTLELTAADRERLAARGVRVVGGRIVRLVADDGRLRGVELDTGRVVNREAVFVFPQPVPRDALLFGLNCARDDNGWVTTDRTGRTSVPGVWAVGNVADPRAQVVTSAGTGAAAAFALNHDLVDEEIGRAVALRRASGPAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M1</accession>
    <name>A0A1E7N1M1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552799.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5559"/>
    <dbReference type="EnsemblBacteria" id="ARF79357">
        <property type="protein sequence ID" value="ARF79357"/>
        <property type="gene ID" value="B6264_10870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34565">
        <property type="protein sequence ID" value="OEV34565"/>
        <property type="gene ID" value="HS99_0035340"/>
    </dbReference>
    <dbReference type="OMA" id="VIREYHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22517" checksum="400A53AF9A5C745E" modified="2017-01-18" version="1">MAGPTTDGRVLRGEETRRAVLRRAVAIASVEGLDALSIGRLATDLGLSKSGVFAGFGSKEELQLATVRAARRIFADAVVAPVADALPGLARARALCENWLAYSRARVFPGGCFFYEVTAEFDARPGAVRDALAGCAREWHGTIVEALTDARTAGALCPDTDLGDLAFALIAVLETANSQAVLHEEDVPYERAGRLLLRLLRAEATDPADPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M8</accession>
    <name>A0A1E7N1M8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558159.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000243.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82037">
        <property type="protein sequence ID" value="ARF82037"/>
        <property type="gene ID" value="B6264_26950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34599">
        <property type="protein sequence ID" value="OEV34599"/>
        <property type="gene ID" value="HS99_0008845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14667" checksum="D93E02EC9242CDE3" modified="2017-01-18" version="1">MFDQAAELPLHVVTGVLLDAALLSLTSPSTTAFRKKWAEGEATYESAQYAGLPDPTPQTAQALRWLLSDERPATRTYGLIAHQARHRYDIPVPFTAGWLISAIKWGGGRAESFPVEADVEAFVLAATTEAALKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Q9</accession>
    <name>A0A1E7N1Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389618.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000792.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4258"/>
    <dbReference type="EnsemblBacteria" id="ARF81995">
        <property type="protein sequence ID" value="ARF81995"/>
        <property type="gene ID" value="B6264_26710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34640">
        <property type="protein sequence ID" value="OEV34640"/>
        <property type="gene ID" value="HS99_0009080"/>
    </dbReference>
    <dbReference type="OMA" id="MYVFDEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="42235" checksum="1A70D398A24B5763" modified="2017-01-18" version="1">MPLRSAGAPGGLPGPFWWLWGGTLVTSAGGFVVPFMTIYLTTVRGYSVFFTGLTLTTFGVGSGIASLFGGILADRVGRRTVLLASEVLTVAGMLGLGLAHGRVPVLLFTLTVGVGLNATRPARAAAVADLVALEDLPRAYSLIYWATNLGFSVAAVTAGLAASHGFLLLFLVNAVANLLAGVMVYLRVPETRPPPESAGVTDAAGAQRPPHRAPGFPVLLGSVLMLGLLFQQPLVALPLTMTGDGLSAADYGAAMMMNGLVIAVLQLPLTRLAGRLRPEHALAVATLVTGLGMGLTAAVHGTVGYGATVVLWSLGEIVVWPTCMALVAALSPPDRQGGYQGWFLSVWSVSVALAPVLSARVIEASGTTAVWGACLCLAVVCAGCHLLLARLRGERRAEAVPGERASVTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N203</accession>
    <name>A0A1E7N203_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4661"/>
    <dbReference type="EnsemblBacteria" id="ARF81935">
        <property type="protein sequence ID" value="ARF81935"/>
        <property type="gene ID" value="B6264_26345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34701">
        <property type="protein sequence ID" value="OEV34701"/>
        <property type="gene ID" value="HS99_0009435"/>
    </dbReference>
    <dbReference type="OMA" id="EFYDYYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="32683" checksum="63C86B11277F3BE3" modified="2017-01-18" version="1">MSMSDIRFESAGIEIAAHLYIPDTPAPGPHPALVVGHPGTGVKEQTSGTYARRMADHGFVTLAFDAAHQGESGGLPRGLEDPAQRVEDFKAAVSYLVTREDVDAERIGLLGICASGGYSLAATGGDHRVRAVATVCTADPSRQFRLGADGGQDPAVFQALLGAAASARTAGARGQDPGVMTMFPQTAAQAGALGGEHGVEGFEYYCTSRGEHERSAKFLAWESIDRLASYDAFFAVPLIGPRPMLQIVGERAVTSWMAVEAHQRATGPKELHWIEGASHVDLYDKKEYIDPAVDKLADFFTTHLGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N205</accession>
    <name>A0A1E7N205_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4645"/>
    <dbReference type="EnsemblBacteria" id="OEV34717">
        <property type="protein sequence ID" value="OEV34717"/>
        <property type="gene ID" value="HS99_0009520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6059" checksum="A786E03F707CB86E" modified="2017-01-18" version="1">MEGGGQQVDRRLAVGARVAHRLAVHRQPDQGFVLLNGVGGVAGEPGADGVVQDVAVDAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N216</accession>
    <name>A0A1E7N216_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555877.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4619"/>
    <dbReference type="EnsemblBacteria" id="ARF81900">
        <property type="protein sequence ID" value="ARF81900"/>
        <property type="gene ID" value="B6264_26120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34738">
        <property type="protein sequence ID" value="OEV34738"/>
        <property type="gene ID" value="HS99_0009650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="25325" checksum="E1866E3F8012EB3B" modified="2017-01-18" version="1">MTTGSVLARSWRSFTGRTLPYSPPPPGHGRNGHSLGQRVWASFTGVELRPARGRTAAPAPVVLPQPRPAPPDRPRAVALAPGWFALPQLPQAGGLAAASGDSVLIEASSPDGSARFLVRGPGVADPDHRLELIVDTAGADRPLMTAVGYTDPDGIGHLLLVPVVRGRFGPPAAYVRLPGFDTGSTLTASDAHPVGPESSLDAEQVAASVRAAVNEATREAWRQVRELLADDSLRAVIDRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N244</accession>
    <name>A0A1E7N244_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81897">
        <property type="protein sequence ID" value="ARF81897"/>
        <property type="gene ID" value="B6264_26105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34741">
        <property type="protein sequence ID" value="OEV34741"/>
        <property type="gene ID" value="HS99_0009665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10635" checksum="770D10662DEEA592" modified="2017-01-18" version="1">MQLGAWEVLLAGRAVRVSESETRSLAVRVSQDAGRDALRPGIGTGIGRPSHFVIPTLGCQRSLRIPTVSRMAGAPASTWRGLWNSALYSTPSTRLRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R9</accession>
    <name>A0A1E7N2R9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830695.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7658"/>
    <dbReference type="EnsemblBacteria" id="OEV34970">
        <property type="protein sequence ID" value="OEV34970"/>
        <property type="gene ID" value="HS99_0034740"/>
    </dbReference>
    <dbReference type="OMA" id="APACLHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="13774" checksum="13C1F5AA711A5D36" modified="2017-01-18" version="1">MGGPGGLLGRFEPPAKPWAAGHRGVDLAAVPGAEVRAAAAGVIAFSGLVAGRPVVTVAHPGSGSPPLRTTYLPVTGTLPVGTTVAAGQVIGRLAPDGRHCGAGDCLHWGLLRGGRYLDPLALLGAGRARLLPLGRGGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2V5</accession>
    <name>A0A1E7N2V5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4684"/>
    <dbReference type="EnsemblBacteria" id="OEV35010">
        <property type="protein sequence ID" value="OEV35010"/>
        <property type="gene ID" value="HS99_0034295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14149" checksum="5213421CAA643506" modified="2017-01-18" version="1">MGELHPDVLRSREFRTAVDAFVDAVSLHNDIVSYDREVEEGTIGNNGVEVARRALGVSRREATALIDGLLTARVDTLAHAPAAVPPGAAGFTRSLQEALAGSYLWHEVTGRFGPCGAAAVGKPRGLGTSAGYAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N319</accession>
    <name>A0A1E7N319_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286732.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000435.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene432"/>
    <dbReference type="EnsemblBacteria" id="ARF78873">
        <property type="protein sequence ID" value="ARF78873"/>
        <property type="gene ID" value="B6264_08050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35072">
        <property type="protein sequence ID" value="OEV35072"/>
        <property type="gene ID" value="HS99_0033955"/>
    </dbReference>
    <dbReference type="OMA" id="WWGGMWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="29461" checksum="D7E5268777F84EF9" modified="2017-01-18" version="1">MSGSQPAAYTHGHQEAVLRSHRSRTAADSAAYLLGQLRPGQALLDVGCGPGTITADLAELVGPGGRVVAVDASAEVLEQAAGYVAGRGLSNVVFELADVHRLPYRDGEFDVVHAHQVLQHLADPVAALREMRRVTTPGGVVAARDVDYASMTWYPEAPALDRWLELYRRTARANGGEPDAGRRLLSWARAAGLTEVTVTTGTWTFATPERREWWGGMWADRVTGTAFGRTAVERGFADRAELERIADGWREWSAAEDGWFSMIHGEVLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L8</accession>
    <name>A0A1E7N3L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5273"/>
    <dbReference type="EnsemblBacteria" id="ARF80690">
        <property type="protein sequence ID" value="ARF80690"/>
        <property type="gene ID" value="B6264_18840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35264">
        <property type="protein sequence ID" value="OEV35264"/>
        <property type="gene ID" value="HS99_0032900"/>
    </dbReference>
    <dbReference type="OMA" id="MIVRIMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10855" checksum="9E642197B15907A1" modified="2017-01-18" version="1">MIMRVMGEGQYEVGEDHLNLLNQLDDELLTAVESGDEENFRQAYGKLLGAVKQYGTLLPDDSLEPSELILPSADASLDEVRALLLSEGEGVIPGFPEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N431</accession>
    <name>A0A1E7N431_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366388.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1613"/>
    <dbReference type="EnsemblBacteria" id="OEV35435">
        <property type="protein sequence ID" value="OEV35435"/>
        <property type="gene ID" value="HS99_0032260"/>
    </dbReference>
    <dbReference type="OMA" id="KVWRGAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="799" mass="86074" checksum="927EF0215E81DC73" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N434</accession>
    <name>A0A1E7N434_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0032195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557968.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1600"/>
    <dbReference type="EnsemblBacteria" id="OEV35424">
        <property type="protein sequence ID" value="OEV35424"/>
        <property type="gene ID" value="HS99_0032195"/>
    </dbReference>
    <dbReference type="OMA" id="NNMEIVQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="28558" checksum="E681CA93205DEBA0" modified="2017-01-18" version="1">MPLAGTGTIVTPAADAARGVGAFNVIQLEHAQAIVAGAEAVGAPVVLQLSENAVRYHGALTPIASAVLATARTASVPVAVHLDHATSADLVTEAVELGFSSVMFDASVLPCEENVRATAEVVARCHAAGVWVEAELGEVGGKDGVHAPGARTDPAEAAAFVAATGVDALAVAVGTSHAMLTRDAVLDFDLIAGLRAAVPVPLVLHGSSGVADEHLTRAVEHGMTKVNIATHLNQVFTGAVRRTLDDDPSLVDTRRYLGSGRTAMAAEVTRLLRVLKAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N455</accession>
    <name>A0A1E7N455_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-1-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283396.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3894"/>
    <dbReference type="EnsemblBacteria" id="OEV35465">
        <property type="protein sequence ID" value="OEV35465"/>
        <property type="gene ID" value="HS99_0032420"/>
    </dbReference>
    <dbReference type="OMA" id="YGAHHIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="29281" checksum="695EA637255BADDC" modified="2017-01-18" version="1">MKVVLFCGGYGLRMRSGTSDDVPKPMAMVGPRPLIWHVMRYYAYYGHTEFILCLGYGAHHIKDFFLNYEETTSNDFVLRGGRTELLSTDIASWTITFAQTGIESPIGERLRRVRHHLDGDEMFLANYADVLTDAPLPEMIDRFAERDAGASMMVVPPQSSFHCVDLGEDGLVGGITAVSDMPLWENGGYFVLRQEVFDHIPENGDLVADGCTQLAKRGRLVAHRHRGFWKPTDTVKERAALDAAYAHGDRPWAVWEREGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4E3</accession>
    <name>A0A1E7N4E3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278215.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5479"/>
    <dbReference type="EnsemblBacteria" id="ARF79423">
        <property type="protein sequence ID" value="ARF79423"/>
        <property type="gene ID" value="B6264_11265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35534">
        <property type="protein sequence ID" value="OEV35534"/>
        <property type="gene ID" value="HS99_0032075"/>
    </dbReference>
    <dbReference type="OMA" id="TAPTCGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16846" checksum="A81F0F4165F3B5EF" modified="2017-01-18" version="1">MSSTTLLRTLQTGHVGLNVTDLNRSIDFYRTVLGLQLTHEGTDPERRYAMLGRDGRLVITLWQQSTGAFSTGTPGLHHLSFEVESLGEVRATENLLRELGAEFAYDGVVPHGEGSASGGIFFSDPDGIRLEIYTRAGVDETPAEAPTTGAPTCGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y1</accession>
    <name>A0A1E7N4Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551034.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene799"/>
    <dbReference type="EnsemblBacteria" id="ARF80957">
        <property type="protein sequence ID" value="ARF80957"/>
        <property type="gene ID" value="B6264_20420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35750">
        <property type="protein sequence ID" value="OEV35750"/>
        <property type="gene ID" value="HS99_0007645"/>
    </dbReference>
    <dbReference type="OMA" id="IRDDLHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="37010" checksum="D6C64AE856C9FB53" modified="2017-01-18" version="1">MRARGISYDTGFVRGGSYSRKLFDPQVVERELRIIRDELHCTAVRIMGGDPDRIELAAGYAAGLGLEVWFSPYPLERTAEEMLRLFADCAGRAERLRLGGAEVVFVAGAELSLMNPGFLPGDTTEERIALLARPEAVREHLGAVRGKVNAFLGEAVATVREHFHGRLTYAAVPLEQVDWTPFDVVSLDLYRSAGTADRFADGVRELTAQGKPVAVTEFGSATYRGAGDRGALGLSVVEYGPDGPVRLDGSYQRDEPGQAAHLRELLTAFDAGGIDAAFVFTFALHDFVHRPDGDPREDLDLASYGIVKVHEDRPGSAFPGLPWEPKEAFAAVGEYYRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N502</accession>
    <name>A0A1E7N502_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0007800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551005.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene769"/>
    <dbReference type="EnsemblBacteria" id="OEV35770">
        <property type="protein sequence ID" value="OEV35770"/>
        <property type="gene ID" value="HS99_0007800"/>
    </dbReference>
    <dbReference type="OMA" id="MSVTACI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="757"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="285"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="694"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="796" mass="80689" checksum="DC3E657F8CACE5D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A1</accession>
    <name>A0A1E7N5A1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0008430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7254"/>
    <dbReference type="EnsemblBacteria" id="OEV35877">
        <property type="protein sequence ID" value="OEV35877"/>
        <property type="gene ID" value="HS99_0008430"/>
    </dbReference>
    <dbReference type="OMA" id="AHACVLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="52682" checksum="AE3494D17C0FE2C0" modified="2017-01-18" version="1">MTLPQPGLTTGSHDLPVSPALDAFMASHWAATPLPADRRVPGHSGFPGRRARLSATFPGERLIVPAGRLKVRCNDLDHRFRPHSAYVWLTGLTGEDQADHVLVLEPAGAAGHEPVLYVRPRSPRDGGEFYRDRRYGEFWVGRRPDLAEAAQLTGLRTEHLDDLGKLLTGPQPPTRVLAGTDPFVDSALDLDGDSLRHGELAAVLSELRLVKDTWEVQQLQLAVDHTVSGFEDVVRALPTALRHHRGERWIEGVFDLHARAEGNGPSYTTIAASGAHACVLHWIRNDGALDPNSLLLLDAGVETDTLYAADITRTLPLGGTFTPVQRQAYELVLAAQSAGIAALRPGARFRDFHRAAMRVIAEGLADWGVLRIPAEQALADDNGLYRRYTLCGSGHMLGLDYHDCAKARADRYVDGTLEAGMVLTVEPGLYLQPDDETLPLELRGLGIRIEDDLVITEDGAHLMSGALPRTVNAIESWMADLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E8</accession>
    <name>A0A1E7N5E8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281723.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene890"/>
    <dbReference type="EnsemblBacteria" id="ARF80880">
        <property type="protein sequence ID" value="ARF80880"/>
        <property type="gene ID" value="B6264_19950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35683">
        <property type="protein sequence ID" value="OEV35683"/>
        <property type="gene ID" value="HS99_0007180"/>
    </dbReference>
    <dbReference type="OMA" id="LWQQGWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="31381" checksum="3CD83DB9ADE21064" modified="2017-01-18" version="1">MSSTDTAPARNDGDTAEVGAGLDALDSVAAQRSSLGEVLRTKALPPLIGVLVVLALWQGAYSLHLTSSYKLPSPADVWRSLQDLWYQGTLFSIIWTSVWRGLSGFLLAVVIGTPIGLVVARVGPVRTAIGPVLQGLQSLPSVAWVPAAVIWLGINDSMMYAVILLGAVPSIANGLVAGIDQVPPLFLRAGRTLGATGLTGARHVLIPAALPGYLAGLKQGWAFSWRSLMAAELVASSPDLGRGLGRFLEDQREFSDMSGVLLGIVLILFVGIAIELLVFTPVERRVLRDRGLLASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I1</accession>
    <name>A0A1E7N5I1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0006740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene977"/>
    <dbReference type="EnsemblBacteria" id="OEV35939">
        <property type="protein sequence ID" value="OEV35939"/>
        <property type="gene ID" value="HS99_0006740"/>
    </dbReference>
    <dbReference type="OMA" id="LLIWPRT"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16018" checksum="2CFD568922BE218E" modified="2017-01-18" version="1">MPAWSEWAGTAVRLGLAVVWGWAGLAKIADPAEAAQAVRAYEILPEGLVKPIGYGLPFLELAFALLLVIGLGVRLVAGASALLLLTFVAGIASAWARGISIDCGCFGGGGHVDASQTEYLQEVLRDTGFLLLAGWLLWRPRTRLSADGWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L3</accession>
    <name>A0A1E7N5L3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348685.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene745"/>
    <dbReference type="EnsemblBacteria" id="OEV35980">
        <property type="protein sequence ID" value="OEV35980"/>
        <property type="gene ID" value="HS99_0007920"/>
    </dbReference>
    <dbReference type="OMA" id="IQWYAED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="18703" checksum="EBEE8886CEAC23D1" modified="2017-01-18" version="1">MLHGTLVTLRPATADDIPALAAIRSTPEVFARWRGGDDLVDEVAEDLESPDTETFAIELGGRVVGAVQWYANNDDEYRHAGMDLYLEPSVHGLGLGTDAVRTMARHLVHDHHYHRLVIDPAADNLAAIRCYTKVGFRPVGTMRQYERGPDGSWHDNLLMDLLADELSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5R3</accession>
    <name>A0A1E7N5R3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0031595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000436.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6333"/>
    <dbReference type="EnsemblBacteria" id="ARF78788">
        <property type="protein sequence ID" value="ARF78788"/>
        <property type="gene ID" value="B6264_07530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36046">
        <property type="protein sequence ID" value="OEV36046"/>
        <property type="gene ID" value="HS99_0031595"/>
    </dbReference>
    <dbReference type="OMA" id="WPTIAFC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11073" checksum="19D1508139F2835C" modified="2017-01-18" version="1">MAWALVVLAGLLETGFAINLKLSEGFTRLWPTISFCVFALGSFGLLTLSLKSLPVGPAYAVWTGIGAAGTAVYGMVFLDETTSVLKLVSISLVIAGVIGLQLSGTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y7</accession>
    <name>A0A1E7N5Y7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280967.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000297.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4965"/>
    <dbReference type="EnsemblBacteria" id="ARF80033">
        <property type="protein sequence ID" value="ARF80033"/>
        <property type="gene ID" value="B6264_14925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36089">
        <property type="protein sequence ID" value="OEV36089"/>
        <property type="gene ID" value="HS99_0030945"/>
    </dbReference>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13544" checksum="B75B2A7430FF9ABD" modified="2017-01-18" version="1">MTAPVIDWARLREAAREAMGHAYAPYSKFPVGAAALVDDGRLVSGCNVENASYGLGLCAECGLVSALHASGGGRLVAFTCVDGAGELLMPCGRCRQLLYEHGGPGLLIELPSGVRPMSEVLPDAFGPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N667</accession>
    <name>A0A1E7N667_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">HS99_0030420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284369.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8116"/>
    <dbReference type="EnsemblBacteria" id="ARF79778">
        <property type="protein sequence ID" value="ARF79778"/>
        <property type="gene ID" value="B6264_13465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36169">
        <property type="protein sequence ID" value="OEV36169"/>
        <property type="gene ID" value="HS99_0030420"/>
    </dbReference>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="27863" checksum="93B1F98BBFD666C1" modified="2017-01-18" version="1">MLLTIDVGNTQTTLGLFDGEEVVEHWRISTDPRRTADELAVLLQGLMGNHTAARDAAVEGLAICSSVPAVLHELREVTRRYYGDVPAVIVEPGVKTGVHVLMDNPKEVGADRIVNALAANHLYGGPCIVVDFGTATTFDAVNARGDYVGGAIAPGIEISVEALGVRGAQLRKIELARPRNVIGKNTVEGMQSGILYGFAGQVDGLVERMARELAKDPDDVQVIATGGLAPLVLGEATTIDVHEPWLTLIGLRLVYERNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N668</accession>
    <name>A0A1E7N668_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ORF">HS99_0007240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388342.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000816.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene878"/>
    <dbReference type="EnsemblBacteria" id="OEV35953">
        <property type="protein sequence ID" value="OEV35953"/>
        <property type="gene ID" value="HS99_0007240"/>
    </dbReference>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="102"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="110"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="199"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="37465" checksum="211ED8473A3108C6" modified="2017-01-18" version="1">MAGYGWTPELDELFAPLAEAGLLPARIVRVDRGQCDAVLADPETGALRTVRFDTRRVGDADMINCPCTGDWAAVDLHAQPMAAVTALLPRSTAIIRKVAGKRSDGQVLAANVDTVLIAASLAADPDLGRIERFLALAWESGAEPLVVLTKADLVDDADFIRADVEAVAPGVTVLVVSAETGEGIDVLRACAPGTTVLIGQSGVGKSTLTNALVGAEVMTVQQAREVDQKGRHTTTTRELMALPGGGVLIDTPGLREVGLYGGEGVDLAFADIAELAEECRFHDCNHHTEPGCAVRTALADGTLPQRRMDSYLKLQRENEWIASRSDARVAKARLNKWKAITKSMRAAGGPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6E3</accession>
    <name>A0A1E7N6E3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0030085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000157.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2661"/>
    <dbReference type="EnsemblBacteria" id="OEV36261">
        <property type="protein sequence ID" value="OEV36261"/>
        <property type="gene ID" value="HS99_0030085"/>
    </dbReference>
    <dbReference type="OMA" id="RCECGEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="83"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="42110" checksum="2320535EF1A2216E" modified="2017-01-18" version="1">MATDDSLATGQRSLGDPALDYPLWPPLTSGCPRTSTEDVSYPVEVDYAYDKADPADLFAPVRARGGLERWAPLLPPLLAPGLGEGATPLVELEPGVYVKDESRNPTWSHKDRLNRCTTSAAVGAGAPGIAVASSGNHGASAAAYAARAGLPCVVFTGPDAPPAVDAFLNAYGAVVLPVPWEARWPLLRQVVERLGLHPVSNLTTTHTGHAYGPEGYKTVAYEIFQDVGVPSAVFVPTGYGELLFGVWKGFEELRRLGLADRVPRVFACESAASGALHRALAEGAPAAHVTVGASEAYSIASPVSGYRGVLAVRGSGGRTLTVDDRQLAEAQGELALAGLWAELSAAAGLAGLRSLGAQAPDDGPVVCVSTSSGFKDKGMGSHRTTPAVPTWEEVERRLRAAGITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N770</accession>
    <name>A0A1E7N770_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386190.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene209"/>
    <dbReference type="EnsemblBacteria" id="ARF83118">
        <property type="protein sequence ID" value="ARF83118"/>
        <property type="gene ID" value="B6264_28220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36484">
        <property type="protein sequence ID" value="OEV36484"/>
        <property type="gene ID" value="HS99_0029385"/>
    </dbReference>
    <dbReference type="OMA" id="PVHMRAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="28464" checksum="01582A22857C7C76" modified="2017-01-18" version="1">MDVPHSARVYDYLIGGKTNFEADRAAAHASVQAWPALPISMRTTRDFMQRSVRHLTEQYGVRQFLDIGTGIPTSPNVHEIAQTIAPEARVAYVDNDPIVLTHARALMSSTPQGRTCYVEADFRDPESIMGNPRLREVLDLAQPVALSLIAIVHFVLDEDDPQGIVRRFMDTLAPGSFLALTVFTGDTDPVGVGGVGREYNARGIPLQIRDKAETEAFFDGYRLLDPGVTLVHHWRPDADAPAIRDRDIAMYAGVAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N788</accession>
    <name>A0A1E7N788_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1478"/>
    <dbReference type="EnsemblBacteria" id="OEV36504">
        <property type="protein sequence ID" value="OEV36504"/>
        <property type="gene ID" value="HS99_0028665"/>
    </dbReference>
    <dbReference type="OMA" id="EYGGFTY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="27801" checksum="9A9992A3F8551B3C" modified="2017-01-18" version="1">MPLSDDQPHTRTRLPVDEQPSTSATLRQSRPLRTLLTVLVVVTLLVVAISIANRGKPAAGGGSSSDHAAPGAASGAGPAPSGDQPVGTTVNGIASGFPHSDQGAQSAAANYSVAIGSADMFRTDSRHTIIATIADPGAAGALQSRLDQGFGGDTAARYGLDAQGRAPKGLTFVSRTVPVGTKSTNYNDGDAKVEVWCTGLTGLAGERSVQPVTTNWFTLALSLHWTGSDWKLTDFTSRQGPAPMPGDQQAATAEEITGAAQQFGGFRYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B5</accession>
    <name>A0A1E7N7B5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0028850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555374.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000290.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1440"/>
    <dbReference type="EnsemblBacteria" id="ARF79162">
        <property type="protein sequence ID" value="ARF79162"/>
        <property type="gene ID" value="B6264_09730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36534">
        <property type="protein sequence ID" value="OEV36534"/>
        <property type="gene ID" value="HS99_0028850"/>
    </dbReference>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21461" checksum="808AE1E31C320133" modified="2017-01-18" version="1">MNSSDPIAEPNAFDLESRVDSADTTLHSQRCAVIALGSNLGNRLDTLQGAVDALADTPGLKIKAVSAVYETEAVGGPEEQPNYYNAVVVLRTSLPPRDLLERGNAIEDAFGRVREVRWGARTLDVDILTYEGVLSEDPQLLLPHPRSHERAFVLAPWLDAQPEAEVPGHGQVAALLAALGGPDAQGVKRRDDIRLTLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E6</accession>
    <name>A0A1E7N7E6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0028985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7890"/>
    <dbReference type="EnsemblBacteria" id="ARF82727">
        <property type="protein sequence ID" value="ARF82727"/>
        <property type="gene ID" value="B6264_09600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36605">
        <property type="protein sequence ID" value="OEV36605"/>
        <property type="gene ID" value="HS99_0028985"/>
    </dbReference>
    <dbReference type="OMA" id="DPMVIDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="693" mass="75040" checksum="7F561AC5E8CA933A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U6</accession>
    <name>A0A1E7N7U6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4789"/>
    <dbReference type="EnsemblBacteria" id="OEV36760">
        <property type="protein sequence ID" value="OEV36760"/>
        <property type="gene ID" value="HS99_0027495"/>
    </dbReference>
    <dbReference type="OMA" id="AFDSHDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002386">
        <property type="entry name" value="Amicyanin/Pseudoazurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00155">
        <property type="entry name" value="AMICYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupredoxin_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10108" checksum="E23C6FA824F98872" modified="2017-01-18" version="1">MTSPSGQPSAPVGANAVTIKNFAFAPATLTVKAGTKVTWSNTDPDAHTVTSKQGSGGPLQSTALATNDAYSYTFTQPGSYAYYCTIHPFMTATVVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N830</accession>
    <name>A0A1E7N830_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284565.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4847"/>
    <dbReference type="EnsemblBacteria" id="ARF82414">
        <property type="protein sequence ID" value="ARF82414"/>
        <property type="gene ID" value="B6264_29230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36804">
        <property type="protein sequence ID" value="OEV36804"/>
        <property type="gene ID" value="HS99_0027780"/>
    </dbReference>
    <dbReference type="OMA" id="TLEICTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="45536" checksum="64D95BE1CD442CE1" modified="2017-01-18" version="1">MDLLPESLTAKLRRGARDPFAVQTLRATVAATLSYGVATQLSSEPAPLTAPLTALLVVQVTVYSTLKTSVRRVVSVVVGVLIAIGFSAVVGLSWWSLGLVILASLVIGRYVRVEEFVQEVAISAMLILGVTKLASQAWDRVLETLIGAAVGLLFNLLFAPPVWVDTAGESIEDLARRARQLLLDISEQLGRPTPVARAVERLHEARRLDQAIADVDAALRQAEDSLRFNPRISEGLLSRLVLRTGLDTLEICVVVIRVLARSVTDLAKRRGPQEQLFPPEVAVGLEELLAHVGGAMVSFAVLVTTQVSRNAEEAEERLTAELAAALATRENVAQVLLRKVQEHPEAWQLHGSMLAEIDRILDELDLEHRSRRLMEELDRASLVSRERFSGLARLRSVLRGGRRRGERERPAVGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Q0</accession>
    <name>A0A1E7N8Q0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556097.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7422"/>
    <dbReference type="EnsemblBacteria" id="ARF81653">
        <property type="protein sequence ID" value="ARF81653"/>
        <property type="gene ID" value="B6264_24560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37076">
        <property type="protein sequence ID" value="OEV37076"/>
        <property type="gene ID" value="HS99_0004430"/>
    </dbReference>
    <dbReference type="OMA" id="KPAYHRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046051">
        <property type="entry name" value="DUF6009"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19472">
        <property type="entry name" value="DUF6009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14765" checksum="D5E801EA66249F27" modified="2017-01-18" version="1">MSALIDPAELAHETDLVWLEDTTDLDYVRQSLDRLTTRRGRPAYHRDGRMVGYAILGPDAKSSRASGTFRRRVFWLLPHDRDQDPDGLYTTGAPSEAVDPRTVAPGVKGYKTERSEGGPASPAMLELGITLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y8</accession>
    <name>A0A1E7N8Y8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556649.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6217"/>
    <dbReference type="EnsemblBacteria" id="ARF81569">
        <property type="protein sequence ID" value="ARF81569"/>
        <property type="gene ID" value="B6264_24055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37166">
        <property type="protein sequence ID" value="OEV37166"/>
        <property type="gene ID" value="HS99_0004935"/>
    </dbReference>
    <dbReference type="OMA" id="GVWGIAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="49395" checksum="82DA32A32509ACDD" modified="2017-01-18" version="1">MTSADNLQAFKREGRIVVVGASLAGLRAAEALREEGFTGSLTMIGDELGEPYDRPPLSKQVLTGWVPAENTKLPRRREVDAEWLLGVPASGLDLATNHVRLADGREVPFDRVLISTGVRGRPWFVESEAALDGVFVVRTREHAAGLQRALAAGPSRVLVIGAGFTGSEIASICRERDIPVTVAELAPAPLVGALGAMIGEVAADMQRAHGVDLRCGVKVTRLEGDAQGRLRRAHFDDGSTIDTDVAVVALGGVRNTDWLQGSGLAAGVWGIACDTGCRALDLNGLVTDDVFAAGDVARCPNPIYEYRLISLEHWANAVEQAEVAAHNMVSGQADRWPHLSIPRFWSIQFGVNIKSVGVPTFADEVVVTQGSVPDHRFVAAYGYRGRVTAAVSFNNAKWLDHYQALIETAAPSPPPCPAPDQPADAKPVPVDFPGPTLLAQGATVVVTGHDPSERRVTAAYQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9D0</accession>
    <name>A0A1E7N9D0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555122.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1273"/>
    <dbReference type="EnsemblBacteria" id="OEV37289">
        <property type="protein sequence ID" value="OEV37289"/>
        <property type="gene ID" value="HS99_0005715"/>
    </dbReference>
    <dbReference type="OMA" id="IAVYRHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="22293" checksum="C6752114FEA510C3" modified="2017-01-18" version="1">MSTADTPSASAGRKRADVRRNEQKLLDAAAAVFVRMGIDAPVREIAAESGLGMGTIYRHFPTRADLVVAVFRHQVDALAAAVDAAPTAGTPYEVLRQWVHQFVDFLVTKHGLAEALHSDQAGFESLHNEFVERLMPVLDQLLKASTAAGYTRSDVRAYDFMLAIGNLCIGVENFPDYQARRMIDLLLAGLARTAPASTGEEPEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F2</accession>
    <name>A0A1E7N9F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37322">
        <property type="protein sequence ID" value="OEV37322"/>
        <property type="gene ID" value="HS99_0005910"/>
    </dbReference>
    <dbReference type="OMA" id="GRVTKKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="17998" checksum="04723CB20904AF35" modified="2017-01-18" version="1">MDCLRSESGRVTKKWVDTNIDTASYRLTVLRENTPARTYKVDRSFYEAVDVGSTVELRSWRGRVAEIIQQKHRSDPPSTPWAAAFRISLLVTAGTALLAGGLAGVFLERWRIQAVILVPLFLLTWGLGARLLLWHWPQALTMGLPALAWLIAAGLATAAAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G0</accession>
    <name>A0A1E7N9G0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366215.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5472"/>
    <dbReference type="EnsemblBacteria" id="OEV37326">
        <property type="protein sequence ID" value="OEV37326"/>
        <property type="gene ID" value="HS99_0005935"/>
    </dbReference>
    <dbReference type="OMA" id="GSPWAMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198915" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="44"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="176"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="31076" checksum="FE87A05550754398" modified="2017-01-18" version="1">MLISGTGRHRRARRRHTPRLAATAGIAGAGLMLPLLSASGASAAPGSHTHASHAGWQEHHQHRHQSDSDSQHRHQAGPPSAPASPDASHASHASHASPSPSAPASHAPESAAARPGGESQGSHPAWPSASTPAPASHTSAPSSPSAQVTHAPAPAAAPATPAAQTGSNSDAVQQVLNLINRARAAQGLPAYTITSGLTDSAEAHNQTMAGGCGMSHQCPGEAELGARETAAGVQWNAAGENIGYGSGVSTSAQDIAALAVSLTQGMLNETPPDDGHRKNILSSVFTHIGIAVHRDASGTVWLTQDFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N8</accession>
    <name>A0A1E7N9N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0003875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37410">
        <property type="protein sequence ID" value="OEV37410"/>
        <property type="gene ID" value="HS99_0003875"/>
    </dbReference>
    <dbReference type="OMA" id="FPRWAAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="36649" checksum="B664205BB7040FF2" modified="2017-01-18" version="1">MRTTGRRAPRVKSWFGVGFALSVGALLAWHAVDAVLQLTSLLTLLLLAVFIAVSLEPVVTWLEHRGLRRGRAVAVVVAGLAAVLAGLLAVVIPPVGEEVSALVDAVPGWLQQLHDRQSTLGRIEDHYHLVERAKEQLGSGGSASGLFGGVLGAGRLLLSTVTDAVIVISVTLYVMAALPDIKAFCYRFVPRSRRAGVEEITEEILSRTGRYMLGNVLTSAVAGLATFAWCAATGVPYSGALGVFVALMDLVPMVGSTIGGIVVSLVALSVSLPIALATAGFYIAFRLLEDYLIMPRAMKFVVDVHPVVTVIAVLLGGALLGLVGALVAVPAAVALGLVLDEYVFPRLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA42</accession>
    <name>A0A1E7NA42_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286532.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1155"/>
    <dbReference type="EnsemblBacteria" id="ARF79032">
        <property type="protein sequence ID" value="ARF79032"/>
        <property type="gene ID" value="B6264_08970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37538">
        <property type="protein sequence ID" value="OEV37538"/>
        <property type="gene ID" value="HS99_0026385"/>
    </dbReference>
    <dbReference type="OMA" id="TEYGHEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23763" checksum="83C898BBC37BC621" modified="2017-01-18" version="1">MRRVVIAEDSVLLREGLTRLLTDRGLEVVAGVGDGAALVKTVHDLAASDALPDVVVSDVRMPPTHTDEGLRACVELRGRYPHLGVLVLSQFVEERYASELLAGSTRGVGYLLKDRVAEVREFADAVVRVAEGGTALDPEVVQQLLSRSRKGDVLANLTPREREVLGLMAEGRTNAAVAKQLVVSDGAVEKHVSNIFLKLGLAQSPEDHRRVLAVLTYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA87</accession>
    <name>A0A1E7NA87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene8000"/>
    <dbReference type="EnsemblBacteria" id="OEV37592">
        <property type="protein sequence ID" value="OEV37592"/>
        <property type="gene ID" value="HS99_0026285"/>
    </dbReference>
    <dbReference type="OMA" id="KGTHSYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="201" mass="21701" checksum="AA59529727EDA7F6" modified="2017-01-18" version="1">MVLLRPLVTDPRIEVGEYTYFDDPDGATRFEERNVLYAYGPERLVIGKYCAIATGTRFLMAGAAHPTIGASTFPFTMFGGSWTEQTLDIVTGLPSRGDTVVGNDVWFGFGATVLPGVRIGDGAIIAAGAMVTADVEPYTIVGGNPAHPIRRRFDDADIERLLRAAWWDWPVELVTEHVRAIMSGTPADIEAIADANGLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAQ4</accession>
    <name>A0A1E7NAQ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366508.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37780">
        <property type="protein sequence ID" value="OEV37780"/>
        <property type="gene ID" value="HS99_0024630"/>
    </dbReference>
    <dbReference type="OMA" id="RERWIGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17860" checksum="14DDA6AA5F7A38F4" modified="2017-01-18" version="1">MTVFRCVRCNQPLTAPLKRLTAFPERPKPVEQEIAPSTVSRGCFAIDPEPFGAPFVPNDDPQEPVAAMAGMTVHRDGAFLKSAGPKDTVVLHPDDAIGLHYHTGRERWIGCCGPSGMYGPNQLCACGNPVGTLVADCLMQNELHLDPRRIWAEEMRAAVKLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE6</accession>
    <name>A0A1E7NBE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CCA tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278265.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000219.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2105"/>
    <dbReference type="EnsemblBacteria" id="ARF82772">
        <property type="protein sequence ID" value="ARF82772"/>
        <property type="gene ID" value="B6264_11545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38011">
        <property type="protein sequence ID" value="OEV38011"/>
        <property type="gene ID" value="HS99_0023875"/>
    </dbReference>
    <dbReference type="OMA" id="HRHKDVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="53171" checksum="F000891228E58953" modified="2017-01-18" version="1">MSEAQALGLQELLRVSPVADEIARRFQAAGHRLALVGGSVRDALLGRLGNDLDFTTDARPQQVLKLVKGWADAVWDVGIAFGTVGARKDTPEGSFLIEITTYRSEAYDRTSRKPEVSYGDTIEQDLVRRDFTVNAMAVDLPGRGFVDPHHGLEDLEARVLRTPATPEESFSDDPLRMMRAARFAAQLDFDPAPGVVAAMTAMAERITIVSAERVQAELNKLLLADHPVKGLRLLVDTGLARHVLPELPALKLERDEHHRHKDVYEHSLTVLEQAIDLEQDGPDLTLRLAALLHDIGKPRTRRFESDGRVSFHHHEVVGAKMTRKRMRELKYSKELTEDVSRLVELHLRFHGYGGGEWTDSAVRRYVTDAGPLLERLHKLTRSDCTTRNKKKAAALSRTYDGLEHRIAELKAQEELDSIRPALDGNQIMELLGLKPGPQVGKAYKHMLELRLEHGPMEPDEAVAALRAWWDGQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW4</accession>
    <name>A0A1E7NBW4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287421.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene476"/>
    <dbReference type="EnsemblBacteria" id="ARF78840">
        <property type="protein sequence ID" value="ARF78840"/>
        <property type="gene ID" value="B6264_07845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38175">
        <property type="protein sequence ID" value="OEV38175"/>
        <property type="gene ID" value="HS99_0023610"/>
    </dbReference>
    <dbReference type="OMA" id="SCDMVVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="266" mass="27885" checksum="BFE9F3269B5CFD40" modified="2017-01-18" version="1">MSDSVLYELDGGLAVITINRPEAMNALDVATKVALRDTVIEAAGDPAVRAVLLTGAGERAFCVGQDLNEHLALLKRFEETGEGALRTVAEHYNPLTRALAGMPKPTVAAVGGVAAGAGASLAFACDFRILSDRAGFNTAFTGIGLTADSGASWTLPRLVGHAKATELLMLPRTVKAAEAMELGLATKVVPAEELAATARVFARELAEGPTVAYGAVKESLAYGASHSLDELLDKEDELQTLAGESEDHRIAVRAFIAKEKPKYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC26</accession>
    <name>A0A1E7NC26_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033354030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000718.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3332"/>
    <dbReference type="EnsemblBacteria" id="ARF80253">
        <property type="protein sequence ID" value="ARF80253"/>
        <property type="gene ID" value="B6264_16235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38235">
        <property type="protein sequence ID" value="OEV38235"/>
        <property type="gene ID" value="HS99_0022045"/>
    </dbReference>
    <dbReference type="OMA" id="CCVIDGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="20936" checksum="B1174779BFFCC922" modified="2017-01-18" version="1">MNFVAATGSSWICALALFAVLGDALLPFIPSGTLVILAVLKTAQINGAPVLLGLGVAVASFLGDLLLLHLARRGAPVLQRRIARRPKLAASVARVQQSLVERPHGGAAAMVVVARFVPAGRTVLDLAIGHSPAHPHRFLHWSALAGLVWAAYIVTLGWLNSHWFNTAWLSLAVSCAAATAVSTAIARIVRRNRRLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW8</accession>
    <name>A0A1E7NCW8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0021645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830797.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3090"/>
    <dbReference type="EnsemblBacteria" id="OEV38539">
        <property type="protein sequence ID" value="OEV38539"/>
        <property type="gene ID" value="HS99_0021645"/>
    </dbReference>
    <dbReference type="OMA" id="ASRTYEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="175"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="708" mass="75791" checksum="EE58C19C21C9BACC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDF3</accession>
    <name>A0A1E7NDF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene589"/>
    <dbReference type="EnsemblBacteria" id="OEV38719">
        <property type="protein sequence ID" value="OEV38719"/>
        <property type="gene ID" value="HS99_0020445"/>
    </dbReference>
    <dbReference type="OMA" id="QAGLWWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="13033" checksum="7018813C36411303" modified="2017-01-18" version="1">MAIVFPVVLLLLLLVVQAALIWYDRQVALTAAREGVDAGRVQAKATEAEAEEAARRQARDFLDRQGVHAYQVETGDSTADTIKVTVELTPPLLIPGLTGPSVRQYAEAPRERFVPPAVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDI6</accession>
    <name>A0A1E7NDI6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553654.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000347.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7323"/>
    <dbReference type="EnsemblBacteria" id="OEV38741">
        <property type="protein sequence ID" value="OEV38741"/>
        <property type="gene ID" value="HS99_0018860"/>
    </dbReference>
    <dbReference type="OMA" id="QTIFHKM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27389" checksum="2DB64C7A0FE1F4DA" modified="2017-01-18" version="1">MQQHWYTGPLASFDTETTGVDVETDRIVSAALVVQLAPGAPAQTTTWLADPGVPIPDGARAVHGITDEQVRAYGRPARVVVAEVTRALAGQARAGRPVVVMNAPYDLTLLDRELRRHHGLTLNAGLGGAGLVVLDPRVLDKHVDRYRKGRRTLTDLCAHYGVDLTGAHDAAADATAAMSLIRRIGARYPAALGGLSAAELHLRQAVWHAAQARGLQAWFDRSGTPERVDVSWPLRPARCMCGRRLDPEHGCEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN7</accession>
    <name>A0A1E7NDN7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">X-Pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290254.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7376"/>
    <dbReference type="EnsemblBacteria" id="ARF81191">
        <property type="protein sequence ID" value="ARF81191"/>
        <property type="gene ID" value="B6264_21855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38784">
        <property type="protein sequence ID" value="OEV38784"/>
        <property type="gene ID" value="HS99_0019120"/>
    </dbReference>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="368" mass="39217" checksum="E2F311D7A110FC95" modified="2017-01-18" version="1">MVDAYAGRRERVREHCSAAGADAALVTRAANVRYLTGCAPCGAALLLTRERALLSLPDDLPPDDSGEHLIDGEVTQVPVPAGADTALAAAAAVGRLGVRDLAVEEHDLTVTRHRAVADLVEGARLADLGQVVERLRVVKDEHEIADLRIAAEIADQALGELLESILVGRTERHLAMELERRMIDHGADRAAFPVSVGTGSHSGRPAHQPTDRRVEEGDFLTVVMGAQYRGYRVSTARTFVIGAPPAPWQVELHRLVFRAQRAGREALGPGVEQCVPDRVARQVLEAAGHTEASPRPVGHGIGLEIREAPRLGPSDMGKLDSRVPVTVGPGVHLPGKGGVRIEDTLVVRPLAEGGPELLTITTKELLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDQ3</accession>
    <name>A0A1E7NDQ3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">HS99_0019225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000241.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7397"/>
    <dbReference type="EnsemblBacteria" id="ARF81210">
        <property type="protein sequence ID" value="ARF81210"/>
        <property type="gene ID" value="B6264_21960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38802">
        <property type="protein sequence ID" value="OEV38802"/>
        <property type="gene ID" value="HS99_0019225"/>
    </dbReference>
    <dbReference type="OMA" id="NMHGEPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19680" checksum="7AC520EB88F9D6D7" modified="2017-01-18" version="1">MAIQPIRLFGDPVLRATAQPVTTFDKELRNLVSDLTDTMLDAPGAGLAAPQLGVSLRVFTYHVDGVTGHLINPDLSLSEEEQEGPEGCLSLPGLRYDTRRAHGVVARGFNMYGDPVTVEGTQLLARCIQHETDHLDGIIFIDRLDREQRKAALKAIRESDWGAGPAPVVKISPHSTFGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDU2</accession>
    <name>A0A1E7NDU2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290515.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6517"/>
    <dbReference type="EnsemblBacteria" id="ARF81290">
        <property type="protein sequence ID" value="ARF81290"/>
        <property type="gene ID" value="B6264_22425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38881">
        <property type="protein sequence ID" value="OEV38881"/>
        <property type="gene ID" value="HS99_0019690"/>
    </dbReference>
    <dbReference type="OMA" id="WHQWFDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="54544" checksum="716F66F4B3B1B33E" modified="2017-01-18" version="1">MSNAPATDVLVVGAGPVGLALAIGLARAGVDCRIIERDPEFRTAGVRGKGVNPRTLEVFDDLGVVEQILDRGVLNLKVRAYEGDRLLQEVDPAVGNPAAPDRPYAGMLLLAQHQTEDVLRGQLSEHGAEVETGTELVGYTQDADGVLATLRQEGRTLQLRARYLVGCDGGRSTVRKLAGIPFLGETWEEERFIMASMDLDGLSPDHMHIWNHPRFGAGAMTIVPMRQDDKWALHAAVEPDEHGELPAPTLDTFRRLFAERAGLPGVRLHEPIWSTVWRPTVRLVERYRDGRVLLAGDAAHCQSAAGGQGMNTGIQDAHNLAWKLAALLRGAPSALLDSYQEERMPIARASLAATSAHHKAAFSGGGDAAGLLAEQFRTMAVQGTDLTGLSLGYRGGPLGRDLDGATGIRAGDRAPDAPCTTADGTPVRLFDLFRGPHFTLLLFGDRPAPAELTGLPGIRTAAVRDPDGHAARGYGLRGDAVVLVRPDGYVSLTGAAADRAVIAEHLRAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX7</accession>
    <name>A0A1E7NDX7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation protein SsgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0018845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030056266.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000495.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7322"/>
    <dbReference type="EnsemblBacteria" id="ARF82984">
        <property type="protein sequence ID" value="ARF82984"/>
        <property type="gene ID" value="B6264_21575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38911">
        <property type="protein sequence ID" value="OEV38911"/>
        <property type="gene ID" value="HS99_0018845"/>
    </dbReference>
    <dbReference type="OMA" id="NDEPVEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14893" checksum="748159CAC922B9E7" modified="2017-01-18" version="1">MNTTVSCELHLRLIVSSESSLPVPAGLRYDTADPYAVHATFHTGADETVEWVFARDLLAEGLHRPTGTGDVRVWPSRSHGQGVVCIALSSPEGEALLEAPARALESFLKRTDAAVPPGTEHRHFDLDRELSHILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE68</accession>
    <name>A0A1E7NE68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557356.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4354"/>
    <dbReference type="EnsemblBacteria" id="ARF83219">
        <property type="protein sequence ID" value="ARF83219"/>
        <property type="gene ID" value="B6264_30215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38990">
        <property type="protein sequence ID" value="OEV38990"/>
        <property type="gene ID" value="HS99_0017945"/>
    </dbReference>
    <dbReference type="OMA" id="HEESIYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="20115" checksum="716239BCB776FB48" modified="2017-01-18" version="1">MIITRAEITDLVRLTQFRVDAARWLAALGSDQWSTTFPSDQIAQSIRSGEVFVVRDSADADDLAATITLDGAADPLLWTPQERQDKAQYVHKLTVDRKFAGLDLGTRLLDWAGDRAARHGAQWLRLDAWTSNIRLQQYYTERGFQHVRTIHDPEAGGSGWVAQRPAELAQHGFDDRTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE70</accession>
    <name>A0A1E7NE70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557373.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4367"/>
    <dbReference type="EnsemblBacteria" id="ARF83229">
        <property type="protein sequence ID" value="ARF83229"/>
        <property type="gene ID" value="B6264_30280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39001">
        <property type="protein sequence ID" value="OEV39001"/>
        <property type="gene ID" value="HS99_0018010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="6492" checksum="751642AB8DE8B321" modified="2017-01-18" version="1">MPLTPGQLAHWNARVLAAGTNAERAPVLWDLARVVAGKDEAAWADLVRLLTQWTQARAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED6</accession>
    <name>A0A1E7NED6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557531.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83263">
        <property type="protein sequence ID" value="ARF83263"/>
        <property type="gene ID" value="B6264_30455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39032">
        <property type="protein sequence ID" value="OEV39032"/>
        <property type="gene ID" value="HS99_0018185"/>
    </dbReference>
    <dbReference type="OMA" id="CLMFVEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="10067" checksum="0AB9DCF7E3B5D63B" modified="2017-01-18" version="1">MTDMDPLVPVLAGLVVDTVWLLDSCEDDEVDPDSAVKMMESVAGVLQRLPEDQLGRFLRTLRGLAESESDPQRREFLESFPGACGLVEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEF4</accession>
    <name>A0A1E7NEF4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557147.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000342.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4085"/>
    <dbReference type="EnsemblBacteria" id="OEV39091">
        <property type="protein sequence ID" value="OEV39091"/>
        <property type="gene ID" value="HS99_0018575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11520" checksum="E816BBB465FCB943" modified="2017-01-18" version="1">MLDREGIRGLRARAQALAGGLREVSAEAVVRRVFAVQAQDATAADLGIRVRGRDITAADIGAAYEDERSIVRGWYMRGTLHTIPSEDAHCQIGVSLNLVSDRSSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH4</accession>
    <name>A0A1E7NEH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557161.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4091"/>
    <dbReference type="EnsemblBacteria" id="ARF83329">
        <property type="protein sequence ID" value="ARF83329"/>
        <property type="gene ID" value="B6264_30895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39100">
        <property type="protein sequence ID" value="OEV39100"/>
        <property type="gene ID" value="HS99_0018620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="12059" checksum="6674CED779C8DAFB" modified="2017-01-18" version="1">MFFSDLTLWLDGHGSDWGQRGTDWEGGLRQLEDAPSPVLYLTLSQYHHAILADSSRQGMKLYFGDGTVEQVTPEVREKARAFMQQTLERDWPGYIGGLIADGKLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI5</accession>
    <name>A0A1E7NEI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557131.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4075"/>
    <dbReference type="EnsemblBacteria" id="ARF83315">
        <property type="protein sequence ID" value="ARF83315"/>
        <property type="gene ID" value="B6264_30795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39082">
        <property type="protein sequence ID" value="OEV39082"/>
        <property type="gene ID" value="HS99_0018515"/>
    </dbReference>
    <dbReference type="OMA" id="NERRYGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31100" checksum="1C062A2AC768CA9F" modified="2017-01-18" version="1">MATTGSAALVVTALGALLTGCAGPNHPVASSYPAAAAPTLADISATPSAAVPSAAPTDLSTLRLPIEQYVLTPAENAELTHATWVLAADCIQHHGITFPTPAALTGLRSGSEVPRRYGPADPAAAAKYGYHNPPAPDGNNVPTDNLSSLPTAQRTTVFSCHQDAQTRLTGGATFGSSPIGEQINSRSYTKAADDDRVKAAFTAWSACMKNAGYTYASPIDAYNDPHWQGTSTAGQQEIATAQADIACKQQTNLIGTWYAVDAAYQQQQIHAHQSELDRDRTAEQQQLTAARKALGQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF25</accession>
    <name>A0A1E7NF25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550184.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000692.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3574"/>
    <dbReference type="EnsemblBacteria" id="ARF82447">
        <property type="protein sequence ID" value="ARF82447"/>
        <property type="gene ID" value="B6264_29415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39248">
        <property type="protein sequence ID" value="OEV39248"/>
        <property type="gene ID" value="HS99_0000550"/>
    </dbReference>
    <dbReference type="OMA" id="RTAERFW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="44029" checksum="212F8F95E0690AA4" modified="2017-01-18" version="1">MRRIAVVGAGQAGLQLALGLVADGCEVTLVAERTPEQVRGGRVLSTQAMFGPALRIEAAAGLDLWTDEAPSVASVDAALVAPPATRVLEFTMPLDEPARSVDQRIKLARWLELLAERGGRVEYRSLDRAGLHALARRHELTVVAAGRGELAGIFERNAARSPFDRPQRALSCLYAHGVGSPDPAAGPRARMHALPGLGELYLQPALTRSGPCDILLWEALPGSPLDAFGDGPEVGVQLDRIRTLLAEYLPWEAEHWRDAEPTDAGAGLWGAVTPTVRRPVAELGSGVDAVHVLGLGDAVVVNDPITGQGANGAARAADAYRQAIREHGDAPFTADWMCRTAERFWQQHARHTVEFTAAMLTMPDHLQGVFAAAAEYPAVARRLANTYAEPSDHAAWLATPELTTAYLSSIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA4</accession>
    <name>A0A1E7NFA4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556014.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39367">
        <property type="protein sequence ID" value="OEV39367"/>
        <property type="gene ID" value="HS99_0001270"/>
    </dbReference>
    <dbReference type="OMA" id="EFREMAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="25115" checksum="2C1ECF1C1A65420E" modified="2017-01-18" version="1">MPLFGNRKNLPKPLCDEHGPCRALAGISVFEARDRLRLLITPTRGLGPDPMARQIDDELSVVMCVNGGKRGGTTEALSIAEHAADQWSISRAELWERAFANLATEQLNRQSFNATNGDVLYAVNGTGAWPGAAQALRLENALGGTELPHGALVTLPTSNAFCAAPIRSASSLNAIRFMIDLSKQLQIKDPAPLTSSIFWYRNGWLENLNVGDNGMMRPSAEFREMANSLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC9</accession>
    <name>A0A1E7NFC9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39410">
        <property type="protein sequence ID" value="OEV39410"/>
        <property type="gene ID" value="HS99_0001535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="80" mass="8525" checksum="5E58FED48E0B1FAB" modified="2017-01-18" version="1">MVDAVNECPHATAHAGLRDFRGRSGPADAVKPAHSRTALVRETTGPERCSDRPDHGAVRRLPRLHLGLGSTVVPRVLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE8</accession>
    <name>A0A1E7NFE8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288844.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39368">
        <property type="protein sequence ID" value="OEV39368"/>
        <property type="gene ID" value="HS99_0001275"/>
    </dbReference>
    <dbReference type="OMA" id="AWNSHDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="13497" checksum="B651162B36FE49AA" modified="2017-01-18" version="1">MDHDFATRFAQDWAAAWNSHDLERILAHYTEDVVFASPRIVELVGDPTGEVRGKEALRVYWAKGLRHLPDLHFTVEDVLVSVDTLVINYRNERGRAVAEVLTFRDGLVCRGFGAYGPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFP3</accession>
    <name>A0A1E7NFP3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481232.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000488.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5070"/>
    <dbReference type="EnsemblBacteria" id="OEV39494">
        <property type="protein sequence ID" value="OEV39494"/>
        <property type="gene ID" value="HS99_0002025"/>
    </dbReference>
    <dbReference type="OMA" id="VYVDFYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="SSF51101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199094" evidence="1">
        <location>
            <begin position="37"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="313"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="47173" checksum="F5E0EEC9B5CE6D0D" modified="2017-01-18" version="1">MSEPRLRRPFVRTVFAGALAAAAALGGLVSAPAAQAAEGGGSFAVLTYNVAGLPQVLSSASTDRQSSTTAIGGRLAPYDLVDVQEDFNYHAALYAADSHPYRTPTSGGAGIGSGLNTLSGLAYDTDDFERVRWNDCQLDSGDCLTPKGFTFLRARLAEGVYVDVYNLHANAGTSAGDEAARAANLAQLTSYIGTHSAGNAVIVMGDTNTRYTRADDTVAAFAADNRLTDAWVQLERGGVAPTRGADPLLCDENAITDTCEVVDKVLYRSSALVSLSATSYHNKHADFLDGSGAMLSDHDPIAVGFSWNQSPAYRTSEQFGGPHGDFYDDIDQVPAGAQAAVIGLRAGSRVDQVQLTLGNGTTLTHGGSGGTASSLGLGSGEYVSSATLCQGAYNGHTRIFYAKFTTSLGRSLAGGTTTADCVTRTAPAGWQLAGFDGRAGDEVDKLGFIFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT8</accession>
    <name>A0A1E7NFT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555594.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6721"/>
    <dbReference type="EnsemblBacteria" id="OEV39569">
        <property type="protein sequence ID" value="OEV39569"/>
        <property type="gene ID" value="HS99_0002500"/>
    </dbReference>
    <dbReference type="OMA" id="RHMQGGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="27446" checksum="E9B271FA740BE88A" modified="2017-01-18" version="1">MTLNLWRQPLGPVAAEMLSTVWDRNELTVLILAEAAISELPPGISRLSRLRTLDLGHNLLTEVPAELGRLTGLRDFLYLHDNQLTALPDSLGRLTQLRYLNVGENRLTELPSSIGKMAELVELRAQHNRLTALPEPIGALGQLRELWLRGNRLTTLPASFRLLSELRELELRENALAELPAVLARLPRLRRIDLRSNEIAELPDWLADPTALPALEKLDLRWNDVEVPDRVGEALAERGCVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV8</accession>
    <name>A0A1E7NFV8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555596.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6723"/>
    <dbReference type="EnsemblBacteria" id="OEV39567">
        <property type="protein sequence ID" value="OEV39567"/>
        <property type="gene ID" value="HS99_0002490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="23750" checksum="0FFAC038EC439D78" modified="2017-01-18" version="1">MIPDRTDPAAIARRILQRRDQLGLSEGMLAYRTHMSPAYLRQLLCAGPEFDREAFLRIATALGTTWSELLTGRRPDAPPGQADPAAPRPLLLHLTGPQCWELLGTHGVGRIGLPGRAAPVVLPVNYTVDARTVVYRTAAQGAAAPTEGSPASFQVDHVDDRRSNGWSVLILGEAHHIDDPDEQRRLSARPGATPWAGGARPLWVRISPSEIAGRRLGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG30</accession>
    <name>A0A1E7NG30_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2820"/>
    <dbReference type="EnsemblBacteria" id="OEV39671">
        <property type="protein sequence ID" value="OEV39671"/>
        <property type="gene ID" value="HS99_0003125"/>
    </dbReference>
    <dbReference type="OMA" id="GPTINTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="689"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="797" mass="83773" checksum="433F346099E88D01" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG40</accession>
    <name>A0A1E7NG40_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367032.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000671.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5110"/>
    <dbReference type="EnsemblBacteria" id="OEV39463">
        <property type="protein sequence ID" value="OEV39463"/>
        <property type="gene ID" value="HS99_0001835"/>
    </dbReference>
    <dbReference type="OMA" id="LGTHPAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="25034" checksum="AAA02E81DDBA11CF" modified="2017-01-18" version="1">MLLAVAHGSRDASSSVTIHTLLRRVRSLRPELLVQYAFLDLNRPSLRDALYQLRSERPILVPLLLSTGYHVRVDIPAAVAAAGLPTSQVARALGPHPLLAEALAARLAETGATPEAPVVLAGAGSSDPTAIADTTRMAHLLARRLGRPVTPAHLSAVGPTPHEAVAALRAAGHHDVAVATYLLAPGFFARRAATTEARWTSPPLAAHDAIARLILHRYDEARTATALPLAPEKVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC2</accession>
    <name>A0A1E7NGC2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2851"/>
    <dbReference type="EnsemblBacteria" id="OEV39698">
        <property type="protein sequence ID" value="OEV39698"/>
        <property type="gene ID" value="HS99_0003290"/>
    </dbReference>
    <dbReference type="OMA" id="CDLAEWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="516" mass="54025" checksum="40070FF2138E0054" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF5</accession>
    <name>A0A1E7NGF5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0003650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550506.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2927"/>
    <dbReference type="EnsemblBacteria" id="OEV39757">
        <property type="protein sequence ID" value="OEV39757"/>
        <property type="gene ID" value="HS99_0003650"/>
    </dbReference>
    <dbReference type="OMA" id="CFGHPMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="31201" checksum="2F93B9602C495FC5" modified="2017-01-18" version="1">MSDIHTVGVVGAGVMGTGLAQALAQTGHRVLLVDRTKEILAAAERTIAQGLRFGRVLGAKGPKEDRRTVLGRIGLTTDYEGFDQADFVIENITEDWGLKKGVYERLDAVCPERTVFAANTSVIPITRIGAATSRPDRVLGMHFMNPVPLKPTVEMIRGHHTSAATVDTARTLLSQLGKEGILVEDSPGFVTNRVLMLTVNEAVYLVHEGVAGAEEVDRIFKTCFGHTMGPLETADLIGLDTILQSVEGLYTAFSDSKYRPCPLLVRMVDAGLLGRKSGQGFYNYATTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK1</accession>
    <name>A0A1E7NGK1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cl-channel voltage-gated family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0002420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481155.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6736"/>
    <dbReference type="EnsemblBacteria" id="OEV39841">
        <property type="protein sequence ID" value="OEV39841"/>
        <property type="gene ID" value="HS99_0002420"/>
    </dbReference>
    <dbReference type="OMA" id="NIRFNKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="447" mass="43841" checksum="01D002B953156E4B" modified="2017-01-18" version="1">MSADHRSPAPGADPSDPAALVRTFGYLELLALAAVLGVLISAAAYGFLALVSRLQSATYTDLPKALGFQGTPPWWPLPLLGVAGLLVGAAVRHLPGTGGHEPTAGLATTGTPSAIELPGVFLAALATLGLGAVLGPEAPLIALGGGLAVLAVKRPGRDVAPPVVAVVGAAGSFAAVSTLLGSPLLGAFLLMEASGLGGPMMGAVLVPGLLAAGIGSLVFLGLGSWTGLGTYSLTLTDVPHADRPDLPGFGWALVIGVAAALLGAGIRRLALLLRARVERRTVPATVVMGLVVAGCAIAYAEATGKGAAEVLYSGQSAIGPLLAGHAGYSVGALGLLVACKGLAYCASLSAFRGGPVFPAMFLGAAGGTALSHLAGLPLTAAFATGIGAMCVALLRLPMTSVLLATLLLGADGLTVMPLVIVSVVVAYVLTLRIGPSGAGASAPVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGT6</accession>
    <name>A0A1E7NGT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0002150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5045"/>
    <dbReference type="EnsemblBacteria" id="OEV39835">
        <property type="protein sequence ID" value="OEV39835"/>
        <property type="gene ID" value="HS99_0002150"/>
    </dbReference>
    <dbReference type="OMA" id="FWNTVLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="30096" checksum="22CC61A5B83E0A1D" modified="2017-01-18" version="1">MPLTTRLAALTRSGLVQTVLIVAAVAWLVPTVGLLVSSLRPKQVAATGGWWTALTEPAQLTLQNYTALLGGGDVPEALWNTVLISVPATLLTVALAAGAGYAFAWMRFPGRDAVFLGVVGLLVVPVQVGLIPVAKLEGAVGLFGTIPGVVLFHVGYGLPFAVFLMRNHFLEIPAELLEAARMDGCGEWRIFRTLALPLAAPAVASLCIFQFLWVWNDMLVALIFAGNDSQPLTVYLQSQMRQFGSNMDILAPGAFLSLLVPVGVFLCFQRFFIQGAMAGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVH7</accession>
    <name>A0A1E7MVH7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279637.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2967"/>
    <dbReference type="EnsemblBacteria" id="OEV32263">
        <property type="protein sequence ID" value="OEV32263"/>
        <property type="gene ID" value="HS99_0016225"/>
    </dbReference>
    <dbReference type="OMA" id="APVHEKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="30411" checksum="59A49F7471E4F536" modified="2017-01-18" version="1">MVTVVFGARGNVARHVADGLLAAGEQVRAVSRTPVPGSTPGRQAVVADLDRPETLPAALDGADKMFLYGMLDPQKPYHIEKVAAAATAAGIRRVVLLSSVSVVNHDADHPVPRLNRTIEQAVQRSGMDWTFVRPGTFAINTRTWWAESVRTDNVVRLPYPLAQSAPVHEKDIAALAVTALTEPGHSHQAYTVYGAESLTLQQQVEHIGEALGRRIRIEHVSDEQARADVGRTMHPVVAEAIVSQWAAADGVPAPTSVIAEKITGTPAHTYAQWAVDHADDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVN0</accession>
    <name>A0A1E7MVN0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366290.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6293"/>
    <dbReference type="EnsemblBacteria" id="OEV32489">
        <property type="protein sequence ID" value="OEV32489"/>
        <property type="gene ID" value="HS99_0017580"/>
    </dbReference>
    <dbReference type="OMA" id="AWQEFRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198471" evidence="2">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="15441" checksum="7F5AE589E274555F" modified="2017-01-18" version="1">MIVTKRNSLRLAAVAALGALFLGTAGTAMAAAPAATDPDPVAATATAPAPAPAPAPVASAPVASVSAGITAKPSVTSVQAWQLFRVTGTTTGLEAGSTVTLQQKQHGTWVTLPASVHTTRNGSYSLGVKLGIKGLNELRIVSGNTASPVFTVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR5</accession>
    <name>A0A1E7MVR5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386320.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7518"/>
    <dbReference type="EnsemblBacteria" id="OEV32527">
        <property type="protein sequence ID" value="OEV32527"/>
        <property type="gene ID" value="HS99_0017190"/>
    </dbReference>
    <dbReference type="OMA" id="TPYSYLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="13444" checksum="172994630B927D0E" modified="2017-01-18" version="1">MDREYDQPLDVPALAATALMSPGHFSRSFRAAYGETPYSYLMTRRIERAKALLRRGDLSVTDVCMSVGCTSLGSFSTRFTELVGESPSAYRARDHADGEPIPACVAKIRTRPVRRTQGRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT7</accession>
    <name>A0A1E7MVT7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0040215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000095">
        <property type="protein sequence ID" value="OEV32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289917.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene106"/>
    <dbReference type="EnsemblBacteria" id="ARF80100">
        <property type="protein sequence ID" value="ARF80100"/>
        <property type="gene ID" value="B6264_15295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32539">
        <property type="protein sequence ID" value="OEV32539"/>
        <property type="gene ID" value="HS99_0040215"/>
    </dbReference>
    <dbReference type="OMA" id="GFITMPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="285" mass="29266" checksum="82AE7C3B209AD4CB" modified="2017-01-18" version="1">MTAQETTGKVWLITGANSGFGQAIAEAALAAGDTVVAAARRPETLAELAAAHPDRVFPVRLDVTDQERIPTVVAETVQRHGRIDVLVNNAGRGLIGAVEESTDRELRDLMDLHFFGPAALTRAVLPHMRARGTGAVVQMSSMGGRFSFPGVGAYSATKFALEGLSEALAPEVAGFGIKVLIVEPGAFRTGFAGGGALAHSAPIDAYEPVVGPVRTGLPDSDGKQPGDPVKAAEAILAALAAEKTPLRLALGSDAVDAVLGNLDGARQEAEAWAAVGRGTDYPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU0</accession>
    <name>A0A1E7MVU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF5063 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000093">
        <property type="protein sequence ID" value="OEV32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288198.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000210.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1912"/>
    <dbReference type="EnsemblBacteria" id="ARF82794">
        <property type="protein sequence ID" value="ARF82794"/>
        <property type="gene ID" value="B6264_12560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32552">
        <property type="protein sequence ID" value="OEV32552"/>
        <property type="gene ID" value="HS99_0040185"/>
    </dbReference>
    <dbReference type="OMA" id="WWQFSYF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032025">
        <property type="entry name" value="DUF5063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038312">
        <property type="entry name" value="DUF5063_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16702">
        <property type="entry name" value="DUF5063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22698" checksum="94E42FCC4E00E698" modified="2017-01-18" version="1">MHGHGSEPDDFAVQIADSVESFVLAVTEVAKGDEPGSAVSLLLLEVSQLLLAGGRLGAIEDVVPEDRFEPDAGPEPDGEQLRERLAELLAPIDVYHEVFDPYGPPEKPNAFRISDDLAGVVSELQHGLTHYREGRVSEALWWWQFSYLSNWGTTCTAVLRALQSLIAHVRLDSPIGAAPDGADTDDDGLTDEQLEQQAGDLMAAELGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV3</accession>
    <name>A0A1E7MVV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000090">
        <property type="protein sequence ID" value="OEV32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32558">
        <property type="protein sequence ID" value="OEV32558"/>
        <property type="gene ID" value="HS99_0040130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="8328" checksum="E7CD061B09BE138F" modified="2017-01-18" version="1">MNHRSDVRAEARLAGSGSGVALAVSAQEPAGGIRAWPPLGGGVTVRQVRLPEGGAGVVVERLPRGSAGRVRVCGVGREMGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVX0</accession>
    <name>A0A1E7MVX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289065.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3802"/>
    <dbReference type="EnsemblBacteria" id="ARF78375">
        <property type="protein sequence ID" value="ARF78375"/>
        <property type="gene ID" value="B6264_05075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32587">
        <property type="protein sequence ID" value="OEV32587"/>
        <property type="gene ID" value="HS99_0015005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="7467" checksum="B466D72FA5420E8D" modified="2017-01-18" version="1">MGYRISGQVTINGRVIQSDNPVLATGTPDASAVPLTRTEYDEVLDLLARLGAADSPEAAAARSLTARLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW00</accession>
    <name>A0A1E7MW00_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385743.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3827"/>
    <dbReference type="EnsemblBacteria" id="ARF78352">
        <property type="protein sequence ID" value="ARF78352"/>
        <property type="gene ID" value="B6264_04945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32608">
        <property type="protein sequence ID" value="OEV32608"/>
        <property type="gene ID" value="HS99_0015135"/>
    </dbReference>
    <dbReference type="OMA" id="GHDGNAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="434" mass="44770" checksum="96EF34E471C72EB2" modified="2017-01-18" version="1">MAAGFGVRNAQLALLDHTGVRTARVGGPEAAELRFPFASVTKLFTATVALQLVRDGDLDLDAALGRYGEEFAAAPNGLGTTVTLRHLLSHTSGLVCSLDDEDRTPRGFAAAAGEPALLFRPGSAFSYSNVGFALVGRLIEAAAGLSWCEAVDTFLLGPLGITPAHLPAPGPSAPGPAIAVGHAVTGAGAVPVDVRVPAAMAPAAALAGTAEDLVAFARLHLADRAEAYRALLDEDGVAAMRGPVPGVEPYGLADGFGLGWARYGAADEPWLGLDAMAGGTTCNLRVQPGTGSVLALVTDSTAGLALWRELAERLRAEGRDVGAPPVGRSEAHPAPGGDADLAGTWANGDMVYRLTGGAGAPLHLEDDTGARYRLDLDGRGRFSAHRLDFLEAPYAGRFLPDPETGVSPLLQFAGRVLRRESPYGEKTGKFRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWM3</accession>
    <name>A0A1E7MWM3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554894.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000198.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3131"/>
    <dbReference type="EnsemblBacteria" id="ARF78315">
        <property type="protein sequence ID" value="ARF78315"/>
        <property type="gene ID" value="B6264_04740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32643">
        <property type="protein sequence ID" value="OEV32643"/>
        <property type="gene ID" value="HS99_0015340"/>
    </dbReference>
    <dbReference type="OMA" id="VDFGHTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="40092" checksum="66A9F33ADF09F648" modified="2017-01-18" version="1">MSTDTPGSQSSLHRANLERVLRAVRMAGSLTQAEIARGTGLSAATVSNIVRELKESGTVVVADTSSGGRRARSVSLSGDAGIVVGIDFGHTHLRVAVGNLAHRVLAEESAPIDVDVSAAQGFDRAEAMVERLLEQAGFRPEKVIGVGLGVPGPIDVETGALGSTAILPGWTGIAPGRELAERLGMPVHVDNDANLGALGELVWGAGRGLSDLAYIKVASGVGAGLVVNGQIYRGPGGTAGEIGHITLDEAGPVCRCGNRGCLETFVGSRYLLSLLTSTLGADLSLPRVVELAHQGDLGCRRVIADAGRQIGTGVATLCNLLNPRRVILGGDLAEAGELVLAPIRDSVARYAIPSAARQLSVVPGTLGGRAEVLGALALVMSEMGESGALGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ6</accession>
    <name>A0A1E7MWQ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0015490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288265.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3161"/>
    <dbReference type="EnsemblBacteria" id="OEV32673">
        <property type="protein sequence ID" value="OEV32673"/>
        <property type="gene ID" value="HS99_0015490"/>
    </dbReference>
    <dbReference type="OMA" id="PKAFGTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="38658" checksum="382BD40F3C479299" modified="2017-01-18" version="1">MPAASRPATATDPIAAASPAGNPIALTDRRPVVPAERLVAEMVPPPRFADVSFGTYIPDRTQPSQYEAVQVLEQFAGTLGRGNGSAPKRSWFRRSAPAPTGPAGVYLDGGYGVGKTHLLASLWHAAPGPKAFGTFVELTNLVGALGFQQAVRTLSGHTLLCIDEFELDDPGDTVLVSTLLGRLVENGVKLCATSNTLPEKLGEGRFAAADFLREIQGLSAHFRPMRIDGQDYRHRGLPDAPPPYADDTVAAVAARTPGASLDDFEALLAHLSVVHPSRYGALLDDVTAVCLRGVHQVDDQSTALRLVVLADRMYDRELPITASGLPFDQVFPEDMLRGGYRKKYLRAISRLVALARDSAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX8</accession>
    <name>A0A1E7MWX8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="9" type="ORF">HS99_0015930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285533.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000387.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7822"/>
    <dbReference type="EnsemblBacteria" id="ARF78214">
        <property type="protein sequence ID" value="ARF78214"/>
        <property type="gene ID" value="B6264_04155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32743">
        <property type="protein sequence ID" value="OEV32743"/>
        <property type="gene ID" value="HS99_0015930"/>
    </dbReference>
    <dbReference type="OMA" id="WEAVTEQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24107" checksum="CD518DCE259E9F3F" modified="2017-01-18" version="1">MAPRPLNEIVEPGWAAALEPVAGRVAAMGDFLRAEIAAGRTYLPSGPNVLRAFQQPLADVRVLIVGQDPYPTPGHAVGLSFSVGPEVRPIPASLINIFQEYGNDLGLPQPSNGDLTPWTNQGVLLLNRALTTAPRKPAAHRGKGWEEVTEQAIRALVARGGPLVAILWGRDARNLRPLLGDVPAIESAHPSPYSASSGFFGSRPFSRANELLVRQGAQPVDWRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX09</accession>
    <name>A0A1E7MX09_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5719"/>
    <dbReference type="EnsemblBacteria" id="ARF81401">
        <property type="protein sequence ID" value="ARF81401"/>
        <property type="gene ID" value="B6264_23035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32985">
        <property type="protein sequence ID" value="OEV32985"/>
        <property type="gene ID" value="HS99_0014005"/>
    </dbReference>
    <dbReference type="OMA" id="DHHGNVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22470" checksum="D76C080BA747A158" modified="2017-01-18" version="1">MGTYQLPDLPYDYSALERAMSAEILELHHSKHHAAYVKGANDTLEQLAEARDKEQFGGLVGLQKTFAFHLSGHVLHSLFWQNLSPEGGDRPEGELADAITEHFGSFEAFKKQLSTATTGVQGSGWGILSWEPLGQRLIVEQVYDHHGNVGQNTTPLLAFDAWEHAYYLQYRNVRPDYVTRLWDVVNWQDVSARFAAVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX70</accession>
    <name>A0A1E7MX70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279828.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5671"/>
    <dbReference type="EnsemblBacteria" id="ARF81446">
        <property type="protein sequence ID" value="ARF81446"/>
        <property type="gene ID" value="B6264_23275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33030">
        <property type="protein sequence ID" value="OEV33030"/>
        <property type="gene ID" value="HS99_0014245"/>
    </dbReference>
    <dbReference type="OMA" id="RGFFWPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14829" checksum="1BA4745F30292A71" modified="2017-01-18" version="1">MDCVFCAVVAGEEPAHRVLDDGTAVAFLDRRPLFPGHVLVVPRAHHRTLADLPAEEVGPFFLRVQRVAAAVERGLGAAGSFVAANNRISQSVPHLHVHVVPRNPKDGLRGFFWPRGKYPDEAGAAEVAARLRAALGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX76</accession>
    <name>A0A1E7MX76_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033347271.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5639"/>
    <dbReference type="EnsemblBacteria" id="OEV33055">
        <property type="protein sequence ID" value="OEV33055"/>
        <property type="gene ID" value="HS99_0014405"/>
    </dbReference>
    <dbReference type="OMA" id="GQHVCYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="22928" checksum="DE6EF0E23653887B" modified="2017-01-18" version="1">MTSTHATRALRAAVFTALAVPMAALGQVVITGRPLPLSLVATASAVVFLVSAVLAGGERRLLHISAVMVPVELLLNTTFNLGQTGCGPVLSEHVSARGVNLLVCGGGSVDGSLLGAPLGHAGQLAPAATQLLLLLVHLVIALAASAWLRLGDSALSGLARALRALRQSVARPLRALLVLLLPAPVRPVLRVPLPVSDHERPRREDVVLSPAPRRGPPVLAPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXF6</accession>
    <name>A0A1E7MXF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283477.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2686"/>
    <dbReference type="EnsemblBacteria" id="OEV33125">
        <property type="protein sequence ID" value="OEV33125"/>
        <property type="gene ID" value="HS99_0014845"/>
    </dbReference>
    <dbReference type="OMA" id="DANYHAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13971" checksum="F56EFB7310525A0B" modified="2017-01-18" version="1">MTISWEDFLARVVERGEYRGEAEADHAARVVLGLLGEHLVGAERLALADALPGTYASLLRDAQPAAEPLTAERFVEAVVGWIDGATPATAQWDIGAVLSTVADLVPGELIDQVIEQLPDGYDLLFGHPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK1</accession>
    <name>A0A1E7MXK1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HS99_0014525</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552412.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5614"/>
    <dbReference type="EnsemblBacteria" id="OEV33162">
        <property type="protein sequence ID" value="OEV33162"/>
        <property type="gene ID" value="HS99_0014525"/>
    </dbReference>
    <dbReference type="OMA" id="LQYCPTC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OEV33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="31227" checksum="1507A3173F2DA745" modified="2017-01-18" version="1">MPELPEVEALSAFLSERLSGRVIARVQPVAISALKTYDPPVTALEGRTVKAVRRRGKFLDIEAEGLHLVVHLARAGWLRWKDALPVEPPRPGAKNPLALRVRLAGGAGDGFDLTEAGTKKGLAVHVVRDPAEVPGVARLGPDPLDPGFGLEDFAALLRGDRRRLKGVLRDQSVLAGVGNAYSDEVLHAARMSPYKLASSLTEEETARLYEALGDTLRDAVERSRGLAAGELKAEKKLGLRVHGRTGQPCPVCGDTVREVSFADSSLQYCPTCQTRGKPLADRRLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX5</accession>
    <name>A0A1E7MXX5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3275"/>
    <dbReference type="EnsemblBacteria" id="OEV33295">
        <property type="protein sequence ID" value="OEV33295"/>
        <property type="gene ID" value="HS99_0038760"/>
    </dbReference>
    <dbReference type="OMA" id="DETWYLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="114"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="371" mass="38347" checksum="6E2198988B808A2C" modified="2017-01-18" version="1">MAPDSDGPTLATRTPGRRRFLTAGVAGAAVLGLGGLLTACGNSGGGGGGNGGGHGSKTGGGSSPDQKSVKQGGDDYATVIEKMKDFGTDAAPGVYPRTIRHAMGETVIPARPTRVVVLDTGELDNVVSLGIQPVGVVHTDGSKSLPSYLKDKAGNPAAVGTINSLNLEAIAALKPDLILGSQLRAQDQYAQLSKIAPTVFSLRPGYPWKQNFLLNASPFGLQAEAKTQLDAYQAAAAAIGARLGDKRPTITPLRFMPGRTRLYAELSFIGTVLTDVPLPQPKIEQVKELAVEVSPEQVDKADADWIFYGVYGSPSSTNQDAVLGGALWKTLGAVKSGQARPVSDETWFLGLGVTAANAVLADLKGFVSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY9</accession>
    <name>A0A1E7MXY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33103">
        <property type="protein sequence ID" value="OEV33103"/>
        <property type="gene ID" value="HS99_0014715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6413" checksum="CE0AAE135F452087" modified="2017-01-18" version="1">MMTSTSSAFKEGSLRREARLSVPPAMTLPDWAAHDLLDVLRPDSDEDETPAADATLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ4</accession>
    <name>A0A1E7MXZ4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="4" type="ORF">HS99_0038845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553716.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000761.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6793"/>
    <dbReference type="EnsemblBacteria" id="ARF78591">
        <property type="protein sequence ID" value="ARF78591"/>
        <property type="gene ID" value="B6264_06410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33281">
        <property type="protein sequence ID" value="OEV33281"/>
        <property type="gene ID" value="HS99_0038845"/>
    </dbReference>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="36454" checksum="F3733A91F1FBFE23" modified="2017-01-18" version="1">MSRTIRLAVVPGDGIGQEVVAEGLKVLEAALPADVKLETTEYDLGARRYHRTGETLPDSVLAELKGFDAILLGAIGDPSVPSGVLERGLLLKLRFAFDHHINLRPGRLFPGVSSPLAGQPEIDFVVVREGTEGPYVGNGGSLRTGTPHEVATEVSLNTAYGIERVVRDAYRRAQARPRKKLTLVHKNNVLVHAGHLWSRIFAEVGAEFPEVATDYLHVDAATIFFVTQPERFDVIVTDNLFGDILTDLAAAVTGGIGLAASGNINPSGEFPSMFEPVHGSAPDIAGQGKADPTATVLSVAMLLEHLGYAAEAARVEAAVAADLAERTGTRSTSQVGDALAGRVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXZ9</accession>
    <name>A0A1E7MXZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7024"/>
    <dbReference type="EnsemblBacteria" id="ARF80419">
        <property type="protein sequence ID" value="ARF80419"/>
        <property type="gene ID" value="B6264_17235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33318">
        <property type="protein sequence ID" value="OEV33318"/>
        <property type="gene ID" value="HS99_0012005"/>
    </dbReference>
    <dbReference type="OMA" id="LWHVTLS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="18802" checksum="854DC9252DF94AFC" modified="2017-01-18" version="1">MERRREAALTGGTAGRRLTSIDGGRGDGPAEPAGPPPQGPGGARGLRPQRAEAAEPPGVPEQARLWHVVLSVAGQTTPLCSLRASLERLAHDHSFFLTARYAADHAEIRYWEQARDLHDAAAIALRLWGEHKVTANLPPWEIVGLEVVDRATYHKRVAEGFGGPPPRLGGVYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ8</accession>
    <name>A0A1E7MYJ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">StaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5200"/>
    <dbReference type="EnsemblBacteria" id="ARF80624">
        <property type="protein sequence ID" value="ARF80624"/>
        <property type="gene ID" value="B6264_18480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33520">
        <property type="protein sequence ID" value="OEV33520"/>
        <property type="gene ID" value="HS99_0013260"/>
    </dbReference>
    <dbReference type="OMA" id="ICALCYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="45290" checksum="E7FEC26C42571788" modified="2017-01-18" version="1">MSGGAAIAAGDSATASGVLLALAVVLASAFVCGRLAARVRQPVVMGEIVGGVALGPSLLGLLPGHLDASLFPAEVQSYLRVLSQLGLVLFMFTVGLRFDVGHLRGAGRRVTAVSLSSVALPFALGVGLAVLLYPWFDKAQLSTDGRLGPALFLGAAMSITAFPVLARIIAERRMQHDPLGSLSLACAAFQDFLAWCALAVVVAVVEAKGLWSLGRLALDTAVVVLVLVGVVRPLLSRLLAPGRRRPLPRPWIHAVLVTGTLVTAWVTAEIGLDAVFGAFMFGAAVPRDRIEAIAPDVPEQIERAGLLLLPAFFAVTGLAVDLTGLGLRGLAVVAAVLVAACAGKFVGAVAAARATGSSRREARVLGILLNARGLTELVILNVGHRLGVIDTRMFTAMVVMALVTTLMTGPLLERHTAGSAGSATLPGPAPEAAQASRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ35</accession>
    <name>A0A1E7MZ35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557087.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000169.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4288"/>
    <dbReference type="EnsemblBacteria" id="ARF80356">
        <property type="protein sequence ID" value="ARF80356"/>
        <property type="gene ID" value="B6264_16845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33694">
        <property type="protein sequence ID" value="OEV33694"/>
        <property type="gene ID" value="HS99_0038375"/>
    </dbReference>
    <dbReference type="OMA" id="WFLWKNT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16459" checksum="D543B485CCD9BDEF" modified="2017-01-18" version="1">MTSRTGFFVLSGVLLLVALLCVGEGVQLIATGKPLGIGIGLCAFVIPLIGVWFLRQTVRFGRASEQLARELEAEGGLPVDELKRTTGGRIDRASADAVFARRRTEAEAAPGDWRVWFRLAVAYADAGDTPRARKTMQHAIRLHSTEPARSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZD4</accession>
    <name>A0A1E7MZD4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="5" type="ORF">HS99_0037615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000580.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4518"/>
    <dbReference type="EnsemblBacteria" id="ARF80376">
        <property type="protein sequence ID" value="ARF80376"/>
        <property type="gene ID" value="B6264_16990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33798">
        <property type="protein sequence ID" value="OEV33798"/>
        <property type="gene ID" value="HS99_0037615"/>
    </dbReference>
    <dbReference type="OMA" id="TVLDTWF"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="306"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="34108" checksum="A37900304D141502" modified="2017-01-18" version="1">MTAESTSLESTSPATGAVATGLATIAADGTVLDTWYPAPALAAEPGPAGTVRLTAEQAEADLGAGAADALRADARRGVEVVAVRTTISSLDEKPLDTHDLYLRLHLLSHRLVQPHGQNLDGIFGLLANVAWTSIGPVPVDKVEQARLAVRAQGGQLAVYGIDKFPRMTDYVAPSGVRIAHADRVRLGAHLAAGTTVMHEGFVNFNAGTLGTSMVEGRISAGVVVGDHSDIGGGASIMGTLSGGGKQVVSVGERCLLGANAGIGISLGNDCVVEAGLYVTAGTRVTTPDGTVAKAVELSGQDNLLFRRNSQTGAVEVIARSGSWGGLNADLHAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW0</accession>
    <name>A0A1E7MZW0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="7" type="ORF">HS99_0038075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033354224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7692"/>
    <dbReference type="EnsemblBacteria" id="ARF78557">
        <property type="protein sequence ID" value="ARF78557"/>
        <property type="gene ID" value="B6264_06195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33753">
        <property type="protein sequence ID" value="OEV33753"/>
        <property type="gene ID" value="HS99_0038075"/>
    </dbReference>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27615" checksum="3998D849DAA2D16B" modified="2017-01-18" version="1">MSDGNSTRKASSASKGSSGSGKAGGPASTEYDVLEGRLGYTLERALLVRALTHRSYAYENGGLPTNERLEFLGDSVLGLVVTDTLYRVHPDVPEGTLAKLRAAVVNSRALADVGRGLDLGAFIRLGKGEEGTGGRDKSSILADTVEAVIGAIYLDRGLEAATEFVHRLFDPLIEESSQLGAGLDWKTSLQELTASVGIGVPEYVVMESGPDHEKTFTAAARVAGEDFGSGVGRSKKEAEQKAAESAWRAIKEKYADRLPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW3</accession>
    <name>A0A1E7MZW3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551698.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77817">
        <property type="protein sequence ID" value="ARF77817"/>
        <property type="gene ID" value="B6264_01745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33961">
        <property type="protein sequence ID" value="OEV33961"/>
        <property type="gene ID" value="HS99_0010900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="20966" checksum="8B958FBEAC82F5C1" modified="2017-01-18" version="1">MSVDGTAPTTVDAARPLQLGPLVRTDDHWVIGDHTRKAHLALLPEGMEHRVVGEEPELVAWSRFRGIHLQVACDPVSATRTFALLTLRPSNPWAGAELGSRLRDPEEDWRANYTHHRALYSFRHILLLRFMLMHVSCEHHPELLGDDTWLTWAVGKLAPLRCYQETTALRMVEETLGDLRRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW4</accession>
    <name>A0A1E7MZW4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280227.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000710.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2218"/>
    <dbReference type="EnsemblBacteria" id="ARF77845">
        <property type="protein sequence ID" value="ARF77845"/>
        <property type="gene ID" value="B6264_01905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33987">
        <property type="protein sequence ID" value="OEV33987"/>
        <property type="gene ID" value="HS99_0011060"/>
    </dbReference>
    <dbReference type="OMA" id="TPIIQFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="46104" checksum="3F0A0027A5330012" modified="2017-01-18" version="1">MNTPTEVPTPTVGPPDLADPRFWRLPAPARAEAFAELRRRPAPVYFGDRATGRGFHALVRHADVVEASRTPAVFRSGPGVTTPEPPRWVRLLFGDSMVNLDDPRHAQLRRIVSRAFTPRLLGRIEEDVRRIATALVDEVERDRPEDFVGPVAAELPFQVICSMMGIPEESRRTILGLVNRTSAGTGVARTRRGRLRVPGRGLAALARMQGIVAEIGRERRRRPAEDLISALVTADVDGRRLTGRELGAFFSLLLVAGVETTRNALAHGLHLLTVHPEQRALLLADLDGRLDGAVDEIVRHATPIVQFRRTVAVDHELGGPGGPLLRAGEKVALYYGSANRDETVFPDPEAFDITRTPNPHLGYGGGGPHYCLGAHLARQEMTVLFRELFTRLPGARSLGEPVLVPSSFDHRVRALRFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW9</accession>
    <name>A0A1E7MZW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2219"/>
    <dbReference type="EnsemblBacteria" id="ARF77846">
        <property type="protein sequence ID" value="ARF77846"/>
        <property type="gene ID" value="B6264_01910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33988">
        <property type="protein sequence ID" value="OEV33988"/>
        <property type="gene ID" value="HS99_0011065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="28816" checksum="3725D9FD14E3034B" modified="2017-01-18" version="1">MTDRIRLMRAAVFAALCVAMAATAHVAMAGAGVSPPVLLGAFGAVLGLTWLLAGTRRGIGVISVWMVAAQSALHLLFQQAGAAGRGGSGLGRLATPDWAALLLCNPDRAGGGLSPVELARMAGIDPDVPPPAGSLRPMAGMHHGAAGSVDGVAMDMGLSGAAGMPGMPPGMTHQMSGGMSGQMSSAMTHGMSTGMALAHVLAALACALLLWRGDAALVRVFELLAALGTVVAGALLLPLLTLFARPLGYRPPAAFRPADRPARPLRSVLLTHAVVRRGPPALALAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N080</accession>
    <name>A0A1E7N080_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0011775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2368"/>
    <dbReference type="EnsemblBacteria" id="ARF77967">
        <property type="protein sequence ID" value="ARF77967"/>
        <property type="gene ID" value="B6264_02630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34107">
        <property type="protein sequence ID" value="OEV34107"/>
        <property type="gene ID" value="HS99_0011775"/>
    </dbReference>
    <dbReference type="OMA" id="HLTHIPR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063928" evidence="2">
        <location>
            <begin position="27"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="48385" checksum="C3CB064959DC038B" modified="2017-01-18" version="1">MRGLTGLCLVALLAAGTATGTVLGGARDGTDVIGHQAAPQVVRSADLYFALNDMDAQAANLLLFGADPDYTKLRKETLDTYEQRRTQADNDLQRVTEAVAGDAAGQRAVRTVIGELGQYEALVARAQLLEEQAHAPAGRPSADALAAYHQATDLLRQRLLPAVDDVTRANAAVVDRNYTDQRDALSGGWWTILVTGLLALAGLGLLQRVLAVRFRRLVNVPLAATTLLALAGLITALTLTSRADHQLVVAKSNSFDSVVALSRARAVAYDLNADESRYLTDPARAAAYEQSFLDKTQSFARVEGAALATYDDKLAALADKHRADHGQVGFGGYLGDELRNITFPGEQDAAERVLTAFQQYQRDDRKIRELNAQGKLKEAVTFDTGTTPGQSNADFDVLSAALDDNQAINQRAFDGAVAATDDDLGATTAGLGAAALVAALALTALGVRPRLREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J5</accession>
    <name>A0A1E7N0J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278492.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1970"/>
    <dbReference type="EnsemblBacteria" id="ARF79583">
        <property type="protein sequence ID" value="ARF79583"/>
        <property type="gene ID" value="B6264_12255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34196">
        <property type="protein sequence ID" value="OEV34196"/>
        <property type="gene ID" value="HS99_0037105"/>
    </dbReference>
    <dbReference type="OMA" id="FATWVIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="11016" checksum="75329C47DFD79320" modified="2017-01-18" version="1">MIRHLVLFKLNEGVAKDDQRALAGAEAFAELGSLIPELREWECGWNTTERDIAYDYAINSLVEDRESLQAYLTHPAHQAAAGQWREFATWVIADIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y5</accession>
    <name>A0A1E7N0Y5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="12" type="ORF">HS99_0036485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551362.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6428"/>
    <dbReference type="EnsemblBacteria" id="ARF78706">
        <property type="protein sequence ID" value="ARF78706"/>
        <property type="gene ID" value="B6264_07050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34344">
        <property type="protein sequence ID" value="OEV34344"/>
        <property type="gene ID" value="HS99_0036485"/>
    </dbReference>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="31731" checksum="7B7CB57EAB6241A3" modified="2017-01-18" version="1">MAGPAFRAAAVRVRVPATSANLGPGFDAFGLALGLYDDVVVRVADSGLAVDIAGEGAGTLPRDERHLLVRSMRAAFDRLGGQPRGLEVVCANRIPHGRGLGSSSAAICAGIVAARAVTIGGPSALDDDALLALASELEGHPDNVAACLRGNFTIAWTDEESAKAVALEPSEQVVPVVFVPAGEVLTETARGLLPKTVPLADAAVNAGRSALLVEALTRRPELLLAATEDRLHQDYRASAMPDSAALVGALRAEGVPAVISGAGPTVLALTDEAGVDKVLSFAGHHGHGGDPAFAAHRLGVDRTGATVLPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N195</accession>
    <name>A0A1E7N195_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286581.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene366"/>
    <dbReference type="EnsemblBacteria" id="ARF78931">
        <property type="protein sequence ID" value="ARF78931"/>
        <property type="gene ID" value="B6264_08380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34470">
        <property type="protein sequence ID" value="OEV34470"/>
        <property type="gene ID" value="HS99_0035815"/>
    </dbReference>
    <dbReference type="OMA" id="TDYDPDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="11976" checksum="610551E102E6EB6C" modified="2017-01-18" version="1">MTSTETTDAPRYVKLKIELIAEITDEGALKAAALQQVAGDEYLDDEERAQSVEAIEVDPSGSLAHFIDPVALLGDVPGVELASATWESAQTEFDPESEEWDEYTVEESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B2</accession>
    <name>A0A1E7N1B2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286569.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene360"/>
    <dbReference type="EnsemblBacteria" id="ARF78936">
        <property type="protein sequence ID" value="ARF78936"/>
        <property type="gene ID" value="B6264_08410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34465">
        <property type="protein sequence ID" value="OEV34465"/>
        <property type="gene ID" value="HS99_0035785"/>
    </dbReference>
    <dbReference type="OMA" id="VWIYLEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="288" mass="30268" checksum="CF9C3B28A7432671" modified="2017-01-18" version="1">MRSSNPVFSREGSFTREPGYAGFGTSGQAGGPYGNPYAGTQYAQPQGQGPLTDDQLHQMYGGPSAGPAATGRMTLDDVVARTAMTLLTVVVAGAVSWLTLPFENYGFAIGASLVAAIVGLVVQFREKISPALVLAYAAFQGFALGATTHVLNTIWSGIAIQAVVGTAVVFGATLYVYKSGRLRVGSKYRRIGLAIGLGFSGLLLINCIAWAFGGGLNTWGGPLGFGIGLLGVAIGAFYLTLDFSEVEEAIARGARQEEAWRAAFGLTFSLVWIYVEMMRLIASLRGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H3</accession>
    <name>A0A1E7N1H3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide-8 synthase acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6123"/>
    <dbReference type="EnsemblBacteria" id="ARF79318">
        <property type="protein sequence ID" value="ARF79318"/>
        <property type="gene ID" value="B6264_10660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34532">
        <property type="protein sequence ID" value="OEV34532"/>
        <property type="gene ID" value="HS99_0035140"/>
    </dbReference>
    <dbReference type="OMA" id="FKEDHGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="82" mass="9119" checksum="A9384AB71F765815" modified="2017-01-18" version="1">MSAVAIDEAKVREIVADCLDLEVEELTLTDHFIDHYGADSLNAIEVLARLEKEFHVTIPQEELANMVNLSAVLEVLSRANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1I5</accession>
    <name>A0A1E7N1I5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289547.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000087.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6119"/>
    <dbReference type="EnsemblBacteria" id="ARF79322">
        <property type="protein sequence ID" value="ARF79322"/>
        <property type="gene ID" value="B6264_10680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34536">
        <property type="protein sequence ID" value="OEV34536"/>
        <property type="gene ID" value="HS99_0035160"/>
    </dbReference>
    <dbReference type="OMA" id="HLIGIWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="369" mass="40150" checksum="2A4A9BFD387BF417" modified="2017-01-18" version="1">MTIPAVRTFDNHTPLVDTELLPGRGTGVNAAHRMYEHLIGIWATGVIEAAHDLGAFTALISGPATASELSSKLGTDLRATRVLLDGLAAYDVVERSRAADGQAVYTLPPEMHDIFAPEGLYSLVGKIRHDRNVAWSAWRNLATNVRTGARNSDGSQQLNQISEEDYTSLVRGINFWAPPIAATLATALREQGWTDGTGRTLLDVGCGTGIYSQLLLQEFSGLNARALDAERIIPIANAQAHRLGVADRFNPEIVDFWADDWGTGVDVALFVNIFHLQTPESARELLLRSAKALTEDGVIAIADHIVDEDSTDGNTQNRFFRLFAASMLATGGGDAFTVHDYDQWLADAGLRRVALLDTPMHRLLLVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y4</accession>
    <name>A0A1E7N1Y4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_052743427.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34692">
        <property type="protein sequence ID" value="OEV34692"/>
        <property type="gene ID" value="HS99_0009390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="16019" checksum="898790D1EF15EF99" modified="2017-01-18" version="1">MSPILLALVPSQGPSTGGNPVLLVGTGLTGATAVLFGTTPALSFTVQFDGAITAVAPPGTGTVPVKVVTPSGTSNTLSYTYQLPAPPTILALVPPIGLAVGGLPVLIVGHGLSGATAVLFGTTPATNFTVLGDGAILAVSPPGTGTVPVTVITPAGTSNGASYTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N333</accession>
    <name>A0A1E7N333_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557721.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7592"/>
    <dbReference type="EnsemblBacteria" id="ARF81775">
        <property type="protein sequence ID" value="ARF81775"/>
        <property type="gene ID" value="B6264_25325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34863">
        <property type="protein sequence ID" value="OEV34863"/>
        <property type="gene ID" value="HS99_0010395"/>
    </dbReference>
    <dbReference type="OMA" id="WNPTLTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="16496" checksum="EB93753C572EF647" modified="2017-01-18" version="1">MRSRILAVAAAAAALVVVQPGPAGAAGDPSTTETFTVTSGALTLTVPASANLGSGAPGTVISAPIGPCTVTDDRALLSASWTVTAAETDFVNGTATIPATNATYTVGSVTTTGTITVTPTNVTLSNTAQTVLTGTAGVGDNTASWDPTISVNVPAGAVGGTYTGTLTQSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N399</accession>
    <name>A0A1E7N399_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="5" type="ORF">HS99_0033925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285485.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000584.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4486"/>
    <dbReference type="EnsemblBacteria" id="ARF78417">
        <property type="protein sequence ID" value="ARF78417"/>
        <property type="gene ID" value="B6264_05330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35179">
        <property type="protein sequence ID" value="OEV35179"/>
        <property type="gene ID" value="HS99_0033925"/>
    </dbReference>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16282" checksum="51F53DDCD19B0AD8" modified="2017-01-18" version="1">MSETPRPRLDVLIRRIDPELPLPEYAQPGDAGADLRTTVDAELAPGERAVLPTGIAVALPDGYAAFVHPRSGLAARCGVALVNAPGTVDAGYRGEIKVIVVNLDPREGVSFRRGDRIAQLVIQQVEKARFHEVAELPGSARAEGGFGSTGGHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B2</accession>
    <name>A0A1E7N3B2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388764.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4464"/>
    <dbReference type="EnsemblBacteria" id="ARF82638">
        <property type="protein sequence ID" value="ARF82638"/>
        <property type="gene ID" value="B6264_05440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35188">
        <property type="protein sequence ID" value="OEV35188"/>
        <property type="gene ID" value="HS99_0033815"/>
    </dbReference>
    <dbReference type="OMA" id="WAFPAPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="47702" checksum="6916EB69CBFAFD60" modified="2017-01-18" version="1">MTFHPQPTPGTPSPWAFPAPERAALGNGITVLHCHRPGQQLVAVEVLLDAPLAAEPEGLDGIAAILARALSEGTDTLSAEEFAGELERAGATLDAHADHPCIRVALEVPASRLQRGLTLLADALRAPALPAEEIERLVANRLDEIVHEQANPARRAAKALYAELFDAADRLSRPRSGTADTVKSIDRAAVKAFYDAHVRPATTTVVVVGDLTGVDLPALLESTLGAWTGSAAEPSVHAPVTGDDRGRVVIVDRPGSVQTQLLIGRIGPDRHDPVWAAQILGTYCLGGTLTSRLDRVLREEKGYTYGVRAFAQPLRSAADGSGRSLLAISGSVDTASTAPALADTWTILRDLAAEGLTDAERDEAVQFLVGVAPLKYETAGSVAGTLADQVEQNLPDDYQAEVYRQLAELPTAAATEAVVAAFPPDRLVTVLVGDAAEIEADVRALGIGEVTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3L1</accession>
    <name>A0A1E7N3L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284793.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000746.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4723"/>
    <dbReference type="EnsemblBacteria" id="OEV35043">
        <property type="protein sequence ID" value="OEV35043"/>
        <property type="gene ID" value="HS99_0034490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13710" checksum="F87A6BFEE26A7953" modified="2017-01-18" version="1">MRWIRRAVRVADGDAFQASLFGALVLALDLWLLSRTEYDPTAVAALVGLDSAGALAGLGIGLVGARVDAHHRRDTTPAVSQGVRLVRCAATGALYVHLLLPVALVADFVLHPDHLIGVLGGTLDRDDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3N4</accession>
    <name>A0A1E7N3N4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="12" type="ORF">HS99_0033175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282852.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000758.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5328"/>
    <dbReference type="EnsemblBacteria" id="ARF80736">
        <property type="protein sequence ID" value="ARF80736"/>
        <property type="gene ID" value="B6264_19115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35311">
        <property type="protein sequence ID" value="OEV35311"/>
        <property type="gene ID" value="HS99_0033175"/>
    </dbReference>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="22798" checksum="226AFAF5C3AC7620" modified="2017-01-18" version="1">MATDPLRARLADARLYLCTDARREQGDLAEFLDAALAGGVDIVQLRDKGLEAKQELAALEVFADACRRHGKLLSVNDRADVAHAARPDVLHLGQDDLPVPAARAILGEDVLIGRSCHAESEVDAAVAEPGVDYFCTGPVWPTPTKPGRPAPGLGLVSYAAKQATDRPWFAIGGIDLGTVDEVLAAGARRIVVVRAITAADDPRAAAAELARRVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3V8</accession>
    <name>A0A1E7N3V8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278663.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2403"/>
    <dbReference type="EnsemblBacteria" id="OEV35370">
        <property type="protein sequence ID" value="OEV35370"/>
        <property type="gene ID" value="HS99_0032680"/>
    </dbReference>
    <dbReference type="OMA" id="WIWAETH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="15601" checksum="3ABCC7373C991FA4" modified="2017-01-18" version="1">MSVGHTAVTTRRPVVWCDDGVDCGIRDLLNRLGDRWSVLAVVELAQGVRRFRELQRALPGISQRMLTLTVRRLERDGLVSRTVHPTVPPQVEYELTPLGHSLTHLVRAMVDWSYSHHDAIVTSRREWDEANPGSEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N440</accession>
    <name>A0A1E7N440_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283407.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3887"/>
    <dbReference type="EnsemblBacteria" id="OEV35458">
        <property type="protein sequence ID" value="OEV35458"/>
        <property type="gene ID" value="HS99_0032385"/>
    </dbReference>
    <dbReference type="OMA" id="YRIDRPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="19975" checksum="3FD950BE748EC002" modified="2017-01-18" version="1">MKVTGVPAIAGAYLFEPTPYADERGFFCRTFDADVLRSVGLDPNAFVQHSLSRSVRGVLRGLHLRSGAGEAKLVRCSYGRVFDVVVDLRPDSPTYRGRAFFELSGDTQASVYVPAGCAHGFQALTGTADVSYRIDRPHDPAEDVTIAFDDPELAIPWPLPATSMSERDRKAPSLAEALSQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N471</accession>
    <name>A0A1E7N471_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1374"/>
    <dbReference type="EnsemblBacteria" id="OEV35253">
        <property type="protein sequence ID" value="OEV35253"/>
        <property type="gene ID" value="HS99_0033370"/>
    </dbReference>
    <dbReference type="OMA" id="AKWCRLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018775">
        <property type="entry name" value="RlaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34817">
        <property type="entry name" value="PTHR34817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10127">
        <property type="entry name" value="RlaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="27446" checksum="5191967383BA41E2" modified="2017-01-18" version="1">MPSGAVPPAGTVLLSGIVGSTAYGFAHAGSDLDRLGLFATPTEELHGLHRPVESHVTTAPDVTLHEAAKWCRLALSCNPTASELVWLPEDLYETVTPLGRELVGIRSSFLSAPAVRRAYLGYADQQFRKLLTRDTTDPATRRRAAKHARHLVRLVEQAVRLHRTGHNLIRLSDPERVRDLGERIADRPRTAEHLLADAADRLSRPGVLPEAPDPRPAEAWLRRVRAAHYNPLPAVPCAPGAPGQSTGGALGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4G8</accession>
    <name>A0A1E7N4G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550612.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2411"/>
    <dbReference type="EnsemblBacteria" id="OEV35363">
        <property type="protein sequence ID" value="OEV35363"/>
        <property type="gene ID" value="HS99_0032640"/>
    </dbReference>
    <dbReference type="OMA" id="FVDYYAE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="37219" checksum="3A6CB504A29907D6" modified="2017-01-18" version="1">MSETPADPPGLDLGRLRSYLDQKLPGIVQGSLRADLIEGGRSNLTYVLSDDASRWVLRRPPLGHVLATAHDMGREYRVMSALRDTGVPVPNMLLIDHDTDVLGAPWYLMEHVPGVAHRSRTTLAAVGEQRVAALGRRLVETLAALHRIDPSTVGLADFGRPDGYLERQLSRWSKQLAASRSRDLPDLDRLHALLSDRLPTSPAPALVHGDYRLDNVLVDDSDTITAVLDWEMSTLGDPLTDIGLLVMYTELAGVGGGIIPSAMTAPGFPKADEIVSYYAELTGRQAADLDWYVAFASFKLAAVAEGIHYRFQQGRTLGAGFERAGEMAPILARHGLGTLKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J0</accession>
    <name>A0A1E7N4J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278629.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000871.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2386"/>
    <dbReference type="EnsemblBacteria" id="OEV35383">
        <property type="protein sequence ID" value="OEV35383"/>
        <property type="gene ID" value="HS99_0032765"/>
    </dbReference>
    <dbReference type="OMA" id="RWLGLNH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22698" checksum="002F03072EDBD906" modified="2017-01-18" version="1">MPGTATRYLYLARHGEATSDGPDGGGLTAAGRRQAVLLGRRLADRPITAVHHGPLPRAAQTARLIGEQLRGAAVSACEEADDYVPCLPAADELPTDSAEFLLQFLSGASAEELARGPELARRAVERFTGPVPGGEERHELVVTHAFLVGWLVRHTLDAPRWRWLGLNAANAALTVLRFTPGRPSSVLLLNDQGHLPEDLRWTGFPPELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M1</accession>
    <name>A0A1E7N4M1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0006935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281820.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene939"/>
    <dbReference type="EnsemblBacteria" id="ARF80835">
        <property type="protein sequence ID" value="ARF80835"/>
        <property type="gene ID" value="B6264_19705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35641">
        <property type="protein sequence ID" value="OEV35641"/>
        <property type="gene ID" value="HS99_0006935"/>
    </dbReference>
    <dbReference type="OMA" id="PFLGTCG"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="25564" checksum="D2BF382362B7EC04" modified="2017-01-18" version="1">MTYLTPRIALVGDRSPAVRSHARVPGLLDALAERDQLVLDAYWIPTEDAGAPGALDGFDAIWLLPGSPYRSEAGALAAIRTAREGGIPFLGTCAGFQHAVLEYARNVCDLGGAVHGEQDPDREEQVIVPLACSLVGHEGAVVITPGTLAERALGATGSLERYHCNYGLNADYLDRLRAHGLRFSGADESGQVRVLELPGHPFFLASLFQPELSGDGTRAHPMIRALAEAAVAHAALGEATPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E1</accession>
    <name>A0A1E7N5E1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286254.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7290"/>
    <dbReference type="EnsemblBacteria" id="ARF81121">
        <property type="protein sequence ID" value="ARF81121"/>
        <property type="gene ID" value="B6264_21385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35910">
        <property type="protein sequence ID" value="OEV35910"/>
        <property type="gene ID" value="HS99_0008610"/>
    </dbReference>
    <dbReference type="OMA" id="TFHGQGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="31045" checksum="5A2EF279A88D3CF0" modified="2017-01-18" version="1">MTADRRTVLRTAAKLAALSASAGLLTSCGSDTPRRAEPGAALAAHPGSVDPQHTTDPAWKGGEEPASPSPTGPAPTATGTPAAPQTSAPPTPPVLPPLAAGTPYEVVHGPRTAKNVALTCHGSGDPKLATALLETAEQHGARLTVMVVGSWLDQQPQMVRRILDAGHELGNHTQNHLDISSMSPDQARAEIAQCADRLKALTGSIGRWFRPSAAQYATSMVAQQAKAVGYEHVLSFDVDPRDYTDPTAAELQRRVLSAVRGGSVVALHMGHQCTIDALPAILDGLGKAGLKAVTASQLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Q4</accession>
    <name>A0A1E7N5Q4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene784"/>
    <dbReference type="EnsemblBacteria" id="OEV35974">
        <property type="protein sequence ID" value="OEV35974"/>
        <property type="gene ID" value="HS99_0007720"/>
    </dbReference>
    <dbReference type="OMA" id="RWIHLIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="415" mass="43299" checksum="FB64AA3B377E6946" modified="2017-01-18" version="1">MRRAGAALFGRRARLRWVHLVLGGALLMPYYLLSVVALGALNPDQGEVRRVLLQFLALFTSLPMAAVTALVPTVRGLEGAAARALCAVARPEELATGPARSWAARRRTALWFVLHLFSGGVVAGMTLAGVPFAVVLLFGFVGSEELARFWTDRFPGWMLTGPALGLALLLLIVGTSAACGALLARWAPVLLGPTPEERLAAAERRATVLAQRNRLARELHDSVGHALSAVGIQASAAARVLRTDPDFAAEALRAIEETARGAVAELDTVLGLLREEEDAAAGAAGPTLAGLDDLLRQLARTGVTVDAELAPGLGALPAEVSREAYRIVQEGLTNVLRHAGPAPAGLRVALDADRLEIELTNPLGPARPSRPGGGRGLRGIGERATALHGGSAVGPSEDGTTWRLAVWLPVGGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N626</accession>
    <name>A0A1E7N626_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281054.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80075">
        <property type="protein sequence ID" value="ARF80075"/>
        <property type="gene ID" value="B6264_15145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36129">
        <property type="protein sequence ID" value="OEV36129"/>
        <property type="gene ID" value="HS99_0031165"/>
    </dbReference>
    <dbReference type="OMA" id="FAHLEVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="25342" checksum="E4747F7FB3059888" modified="2017-01-18" version="1">MNTGEWPTWAERSLSGARLQTYATAAGGRSAAIRLYWWNIEVSAAFYGPLHCLEVALRNALHGALMHRFGRPDWWSIAPLDADGARLVSDAQTKCGRRINHRPATADDVVAELSFGFWVKLLSRRYDRTFWVPALHRAFPRGSGRRDDLHRQFTTMMLLRNRISHHEPIHHRRLEADHATLFRLLDLLNADLSAEARQLDRVPTVLKQRQDTCAGLRTPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N654</accession>
    <name>A0A1E7N654_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79798">
        <property type="protein sequence ID" value="ARF79798"/>
        <property type="gene ID" value="B6264_13575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36186">
        <property type="protein sequence ID" value="OEV36186"/>
        <property type="gene ID" value="HS99_0030525"/>
    </dbReference>
    <dbReference type="OMA" id="WADAHPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15018" checksum="7CAF12011C0E62D9" modified="2017-01-18" version="1">MSRRENRQLAVASATVGPWRTAAGVGAVVGATALGIEAISGDWSLSMLAEPAGWGLFFFFLVGWAGNQLRGDGGDRRLKRWAREHPWQSALPAAGGLLVLNTVAQMLLGDEGLFGALLVSLIPAAVLMSVAGVVHGVKQARSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6M5</accession>
    <name>A0A1E7N6M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280487.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7174"/>
    <dbReference type="EnsemblBacteria" id="ARF82350">
        <property type="protein sequence ID" value="ARF82350"/>
        <property type="gene ID" value="B6264_28845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36357">
        <property type="protein sequence ID" value="OEV36357"/>
        <property type="gene ID" value="HS99_0029810"/>
    </dbReference>
    <dbReference type="OMA" id="YGICELC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="16162" checksum="EEE042834DE95021" modified="2017-01-18" version="1">MTTARDIMHTGAQCIGAHQTLDEAARMMRDMHVGALPICGDDQKLHGIITDRDIVLRCVAEGKNPAEMTAMDLAGHLHCVRAEDSMETVLKKMEQHQIRRIPVIDGERLVGMISEADLAMGHREGHRLTDEQIIKFMDSVYMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N752</accession>
    <name>A0A1E7N752_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">HS99_0028765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288976.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1457"/>
    <dbReference type="EnsemblBacteria" id="ARF79177">
        <property type="protein sequence ID" value="ARF79177"/>
        <property type="gene ID" value="B6264_09815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36520">
        <property type="protein sequence ID" value="OEV36520"/>
        <property type="gene ID" value="HS99_0028765"/>
    </dbReference>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="15370" checksum="6395E1C6170C8EFB" modified="2017-01-18" version="1">MRAVVQRVTEARVTVAGETVGAIEGPGLCVLVGVTHEDTPAKAAQLARKLWTLRILPVNDEGVEQSCSDIGGPLLVISQFTLYGDARKGRRPTWTAAAPGPVAEPLVDEVVAQLRALGAKVETGRFGADMQVALVNDGPFTVLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I3</accession>
    <name>A0A1E7N7I3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278939.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2540"/>
    <dbReference type="EnsemblBacteria" id="OEV36645">
        <property type="protein sequence ID" value="OEV36645"/>
        <property type="gene ID" value="HS99_0028145"/>
    </dbReference>
    <dbReference type="OMA" id="PLGACHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="51132" checksum="FA77E596E1ACC6F2" modified="2017-01-18" version="1">MNLIERPVVTTESGSVRGTAEDGVAAFRGVPYAASPVGERRFAAPAQHPRWPGLRDADRPGPSVPQSPSRLEAVMGRRTPDWNEDGSLTLNVWTPSLPADGAAPRALPVLLWFHGGGFTSGSGGWDWYDGRNLAAAGEIVVVTANYRLGPLGYLYLPEHGIENLGVQDQAAALAWVRRNVASFGGDPDNLTVGGQSAGAFSALYLALSPVTGPHINRLITQSGPFGLGPQDPEEAADHARSYLDLLGLNGSPDPRAALRAVPVVQLLAAYQQLSQDLSRPGNVAPPMYPVLGATGMPVAWQQAVATGRLDGKDLLTGTTRNEMTSFFAFDPRIRAITAGQARSIVAGQTGGGAERFDRAAARLPGAAPSEVLTEVATELVFRDGTIAIADHHAAADNPAYVYQFDHAPAGDPAHLGAAHCVELPFFFNTFDAYPDSPMLGEATAAARTLGDTFSRAAAAFTATGRPATDGWQPYASADPTSIRHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7I9</accession>
    <name>A0A1E7N7I9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0028100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385901.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2548"/>
    <dbReference type="EnsemblBacteria" id="OEV36638">
        <property type="protein sequence ID" value="OEV36638"/>
        <property type="gene ID" value="HS99_0028100"/>
    </dbReference>
    <dbReference type="OMA" id="ACDAYIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="26279" checksum="BEB452E670A51424" modified="2017-01-18" version="1">MSAGLEIAPDEGRESGRRRRRERKKRPWWQEMLILVAVALVLALGLKTFFVQAFSIPSGSMRNTLQVGDRVLVDKFTPWFGAKPERGDVVVFRDPGNWLRDEPTPRVSGVQKALSFVGLAPAADEKDLIKRVIAVGGDTVDCEAGAPVRVNGVALDEPYLYPGATPCGDRPVGTVKVPKDKLWVMGDHRNDSRDSRYHTDEPGGGFVPVQNVIGRAFVVAWPLSHWGTLPVPATFDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7L7</accession>
    <name>A0A1E7N7L7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289752.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene191"/>
    <dbReference type="EnsemblBacteria" id="OEV36463">
        <property type="protein sequence ID" value="OEV36463"/>
        <property type="gene ID" value="HS99_0029470"/>
    </dbReference>
    <dbReference type="OMA" id="VPHTEVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="88"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="243" mass="26710" checksum="D34DB7E9EF893D1D" modified="2017-01-18" version="1">MDRPQIWLDFAPELHLFVSAPRRAGRTALRTDGTSTLGHVVESLGVPLTEVGALLVDGRPVRDSHVPADTEHVSVEAVARPQPSPAPPRFLLDVHLGTLARRLRLLGVDAAYENPDIGDAALAARSAAEQRVMLSRDRGLLRRRELWAGAYVYSHRPAEQLRDVLSRFAPPLAPWSRCTTCNGTLRTVSKTTVREQLHDGTERSYDAFAQCADCGQAYWRGAHHARLESIVTEAVREFGGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P9</accession>
    <name>A0A1E7N7P9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0028540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386297.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000304.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2457"/>
    <dbReference type="EnsemblBacteria" id="ARF83030">
        <property type="protein sequence ID" value="ARF83030"/>
        <property type="gene ID" value="B6264_23825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36726">
        <property type="protein sequence ID" value="OEV36726"/>
        <property type="gene ID" value="HS99_0028540"/>
    </dbReference>
    <dbReference type="OMA" id="ACGMNMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="735" mass="74659" checksum="8849DF261A314CC7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7S1</accession>
    <name>A0A1E7N7S1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555384.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1466"/>
    <dbReference type="EnsemblBacteria" id="ARF79184">
        <property type="protein sequence ID" value="ARF79184"/>
        <property type="gene ID" value="B6264_09855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36513">
        <property type="protein sequence ID" value="OEV36513"/>
        <property type="gene ID" value="HS99_0028725"/>
    </dbReference>
    <dbReference type="OMA" id="SAHLAYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="24560" checksum="83B2F29D04D3A39F" modified="2017-01-18" version="1">MRGWLKATIGLAVLAGLLVGADRIAVGVAEDEAADRLVKSGQMSQRPDVTIEGFPFLTQAVSKKLDDVRISSDGLTVRNNGQQVALHSFKAKLSGVDVSDSLNSATVDSSTGSGVITYQDLAQLLPPASQLLGGAPLPGGANSRLSLSYGGPGKVKASLGPVSVGEATVHNQGNTVTVDGLKLSSLAEMFAGLANRKVEPAAFTLDSMPAGLKLAAKDGVTPLPEGLQLSFEGKDVKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8I8</accession>
    <name>A0A1E7N8I8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5975"/>
    <dbReference type="EnsemblBacteria" id="OEV37007">
        <property type="protein sequence ID" value="OEV37007"/>
        <property type="gene ID" value="HS99_0004020"/>
    </dbReference>
    <dbReference type="OMA" id="YSRFNGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17981" checksum="E7E93AFC4757F08F" modified="2017-01-18" version="1">MTRAQLTDAEWVLIEPYLPIGEYGPYPERLRQQFEGVIWRFRTGGQWREVPKEFGAWSTVSNRFRQWRDAGVFEALMEGLIAEAAKRGEVDLSLVSVDSTTVRAHHDAAGMHLGPDALAALEKAAGEAEKARQKGEARRNKTGGTPQVTRNGQNGDASGGGASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R4</accession>
    <name>A0A1E7N8R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000394.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81660">
        <property type="protein sequence ID" value="ARF81660"/>
        <property type="gene ID" value="B6264_24610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37069">
        <property type="protein sequence ID" value="OEV37069"/>
        <property type="gene ID" value="HS99_0004385"/>
    </dbReference>
    <dbReference type="OMA" id="WQALKVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="22016" checksum="0CD1F456F78CE8DA" modified="2017-01-18" version="1">MSIRIASRRRAMASLIAAFPGAEIIDVTSKAPEPWVRFSPFFPHGGIPVPFSEGVTSQSVEGIWQALKVFHDSDVDPAKLGVTTMKGLKRTVRRYGPVQGHRTGLDGDRLLPYETARRRIYLPAYRWILEHRVADLVEQLRTGSDVVLLDYTTNGDVTDPTTPLSHAALIQLHIEGRWPTEDDEDGPDAPVSLSHRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8V0</accession>
    <name>A0A1E7N8V0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555721.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6656"/>
    <dbReference type="EnsemblBacteria" id="ARF81607">
        <property type="protein sequence ID" value="ARF81607"/>
        <property type="gene ID" value="B6264_24275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37125">
        <property type="protein sequence ID" value="OEV37125"/>
        <property type="gene ID" value="HS99_0004720"/>
    </dbReference>
    <dbReference type="OMA" id="MSTEQNL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14606">
        <property type="entry name" value="Lipase_GDSL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42497" checksum="B07A427FC469C09E" modified="2017-01-18" version="1">MSTEQNLITTPITADFLRGHLDVEETAHGLLPHRLPAWARRRIPDDRLAVAEAQPSGVRLVFRTNATTIRLDTLPTKRVYRGFPPPPDGIYDLLVDGRLTAQATVDGGNLRTITDMQTQTADFTPGPAGTAHFTDLPPGEKDIEIWLPHAEITEVIALRTDAPVEPAPDKGRRVWLHHGSSISHGSNAVFPSTIWPALAASAGDVELINLGFGGSALVDPFIARAMRDTPADLISLKLGINIVNSDAMRLRAFAPAIHGFLDTIREGHPTTPLLLVSPILCPTHENTPGPLMPDLSSGTLKFRATGDPAETAAGRLTLTIVREVLADIVEQRSVEDPDLHYLDGLDLYGESDHDEFPLPDAIHPGPEGHRRISENFAERVFANHGPFAITTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N922</accession>
    <name>A0A1E7N922_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6173"/>
    <dbReference type="EnsemblBacteria" id="OEV37195">
        <property type="protein sequence ID" value="OEV37195"/>
        <property type="gene ID" value="HS99_0005135"/>
    </dbReference>
    <dbReference type="OMA" id="AMQRINV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17879" checksum="60E37116686A9EEC" modified="2017-01-18" version="1">MNGDIRGIVLLAATVLTGLMAGTYFVFSVAVMPGLGQSDDRTFVEAMQRINVAIQNGWFVLAFGGALVLGLVAAFQHRHGEGRPALAWIVAGVVLYVISLLITMGLSVPLNNQLAEAGSAGRIHDLAAVRARFEATWVHWNVARTLVTTASLVCLVWAIRVARGVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N982</accession>
    <name>A0A1E7N982_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555204.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1320"/>
    <dbReference type="EnsemblBacteria" id="OEV37251">
        <property type="protein sequence ID" value="OEV37251"/>
        <property type="gene ID" value="HS99_0005475"/>
    </dbReference>
    <dbReference type="OMA" id="IWEKRYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="36814" checksum="C47A3BFA2A317B22" modified="2017-01-18" version="1">MVTPSAERAAGARGGGPAAAHDTPQDVGLATGRVAQRLGVSPTTVRSWERRYGIGPANREAGHHRRWSPQDVAVLEAMCRLTARGIPPGEAARAALAEKGSATEINTASPVLSRPDPLSRDDVQAFHRPSAGGSRALGVGTVRPECRGLARAAVRLDAPQIVAILREAVATLGVIDAWTEVMMPALRAAGRKWAADGEQYVEVEHLLSWHVSSVLRGVAVATAATRPVSPVLLAATPTELHTLPLEATAAALAERGLPFRILGAAVPPRALLDAVQRLGPAAVMIWSQDRRSADHELARRISASVWGPRGSRGGAVVVAAGPGWARSRLPIGAAGPRTLADAVDFLEETVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R2</accession>
    <name>A0A1E7N9R2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7417"/>
    <dbReference type="EnsemblBacteria" id="OEV37422">
        <property type="protein sequence ID" value="OEV37422"/>
        <property type="gene ID" value="HS99_0004450"/>
    </dbReference>
    <dbReference type="OMA" id="ELAWMAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="30194" checksum="E0A0C5317C5CBDCC" modified="2017-01-18" version="1">MRIGAGVAGGGALLGAAAGGGMLAGWVPGGVTLKKALGMTGTDGRIPAVAPGPVRVEKVRSAARGREVTMVTMLPPGAAASTNLPVCVLLHGRGNDAQGMVTLGVPQFLAAAVQGGVPPFAVVAVDGGDATYWHRQAADGDDPQAMLREELPGWLHARQLPTPRAVTGISMGGSGALQYAVGRTQAGRNLDAVALLSPAVFRTWADARTTGGYADETDWQAHEPTLRLDQLQTGTLGVWCGQEDPFCPAARQVARQARARVGRFPDGEHTDGFWRRVMPDAMSLLGHALATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9W2</accession>
    <name>A0A1E7N9W2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556587.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6181"/>
    <dbReference type="EnsemblBacteria" id="ARF83032">
        <property type="protein sequence ID" value="ARF83032"/>
        <property type="gene ID" value="B6264_23875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37434">
        <property type="protein sequence ID" value="OEV37434"/>
        <property type="gene ID" value="HS99_0005100"/>
    </dbReference>
    <dbReference type="OMA" id="GGMWLTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="42206" checksum="306642D69786C1BF" modified="2017-01-18" version="1">MTLLFATTTAACLVVLAAVAVHTDGRSRARGLDDTVSHGADGLARVLYYDDGGVLRLDGIYEDSLADHAMALGVIQAAPGAAPQLRHAQPARTALPDQTRLEELWRTVQREQETVVVTAPAADGRSYRWAVAPVWDGKVLDSAVLVGTDPARSEADHVRLVEWLAAGCAVLVLVAAAVGHLLTGRAMRPALRGLEQQEQFLAEAAHELRTPLATLRVVVEQGDTAEGGAPAALDEATRLVDRLGRLVTGLLARARVEAGTQEIERTPLRLDQLVEQTVEELPDTDGVTVSAEAVVVEGDPELLAQAVRNLVENALRHGGGTPVEVTVTAGRVAVRDHGPGVPAGEHERVFERRVAGAGSTGTGTGLAIVRWVAELHGGTARLSEAPGGGTVAELCLPERTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA56</accession>
    <name>A0A1E7NA56_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286454.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1112"/>
    <dbReference type="EnsemblBacteria" id="ARF78994">
        <property type="protein sequence ID" value="ARF78994"/>
        <property type="gene ID" value="B6264_08760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37575">
        <property type="protein sequence ID" value="OEV37575"/>
        <property type="gene ID" value="HS99_0026595"/>
    </dbReference>
    <dbReference type="OMA" id="WVDQQRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="36355" checksum="7113BBDC9B504717" modified="2017-01-18" version="1">MSSSGLIYAVIVGAWAAYLVPMWLRRQDELNEARPTERFSTAIRLLAGRSALERRAARALGDEPRDGEQSNDGPPEGDEAASGDPATREPEPAPERPAERPAPLRAVGGERRARLLARRRRMVTVLFLAFALGAVVAAVAGLAFLWVPAVPALLLTLYIGHLRKLERQRYEVKLDRTRAAQAAERLRQRERQRAEAPTDDRPTVETPVAVEPDRDPPAEQGAGRRPHLRLAAEAGEATVQMASASAVAEATEHEEWVDGMRERGAAGPDSWEPVPVPLPTYVTAPVAPRVSRGLDLSAPGTWTAGRPAETRSTPLFDQYAEAPAPEPRPRAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA65</accession>
    <name>A0A1E7NA65_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0026240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552698.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7991"/>
    <dbReference type="EnsemblBacteria" id="ARF82718">
        <property type="protein sequence ID" value="ARF82718"/>
        <property type="gene ID" value="B6264_09115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37590">
        <property type="protein sequence ID" value="OEV37590"/>
        <property type="gene ID" value="HS99_0026240"/>
    </dbReference>
    <dbReference type="OMA" id="GTWEGQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="585" mass="58415" checksum="18D150DD32EFC0BF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAC6</accession>
    <name>A0A1E7NAC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366729.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1717"/>
    <dbReference type="EnsemblBacteria" id="ARF79896">
        <property type="protein sequence ID" value="ARF79896"/>
        <property type="gene ID" value="B6264_14170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37639">
        <property type="protein sequence ID" value="OEV37639"/>
        <property type="gene ID" value="HS99_0025385"/>
    </dbReference>
    <dbReference type="OMA" id="IDHALVC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="35533" checksum="E4CABF0D48CD3C18" modified="2017-01-18" version="1">MSAPHRPDFPAGDLVDPVLTVHPLGRALGLPKRPNARADSALVLTTPSGEHQVYLPPHRPGFSDLVGRGYQAAFEVDLGLHHLRIEERLPGRDDIGAFEAMVEIDWQVSAAELVVASRIRDVPALLTPRIRQRMRAVTRNLTTDQSGEAETAVQQALDEYPVAEAEGLRVRCAVQLDIDQAARDQKERLRGYHFDTQAHPHALRQVEESHEILAAKAKFYQYHLEQGGVAAWALQVAAHPEDLKEALKYLKDEQRELVQGQLHVIERLLGQNALEEFELEGPRQDAKAALEALLRQRPAGPASPGPGAPRLDKGPNPPLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAJ3</accession>
    <name>A0A1E7NAJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1634"/>
    <dbReference type="EnsemblBacteria" id="ARF79972">
        <property type="protein sequence ID" value="ARF79972"/>
        <property type="gene ID" value="B6264_14590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37715">
        <property type="protein sequence ID" value="OEV37715"/>
        <property type="gene ID" value="HS99_0025800"/>
    </dbReference>
    <dbReference type="OMA" id="LCRADAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009452">
        <property type="term" value="P:7-methylguanosine RNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="316"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42624" checksum="CD7197EC94A35AEB" modified="2017-01-18" version="1">MDTENLQPLLTPRGQALLAELREFAPEEELALATRLRREHPAELVSAAFGQARLRQRARAKFGADADLMYFTPNGVEQSTRRSVAEWRAHRFAGLGVRRLADLCCGIGGDVLALARAGIEVLAVDKDPAACAATAANAAALGLAELVEVVCADVAEVDVTGYDAVFTDPARRTSRGRVFDPEAYAPPLSWAIEAGRRTPIGALKVAPGIPHEAVPADAEAEWVSDHGDVKEAVLWFGTGADRPHRATLLPQAASLTGGDLPDPPAGPVGQYLYEPDGAVIRAHLVAEVAEQVGGRLIDPKIAYLTSDRLVATPYAHAFELTDVLPYNVKKLKALLRERGVGTVVIKKRGMAITPEELRRQLKPSGPNTVTVILSRTDNGPLMMLGQPARTPQEAGGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAM8</accession>
    <name>A0A1E7NAM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0025380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280690.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1718"/>
    <dbReference type="EnsemblBacteria" id="ARF82829">
        <property type="protein sequence ID" value="ARF82829"/>
        <property type="gene ID" value="B6264_14165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37741">
        <property type="protein sequence ID" value="OEV37741"/>
        <property type="gene ID" value="HS99_0025380"/>
    </dbReference>
    <dbReference type="OMA" id="PARSAWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="DUF5706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="DUF5706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="16764" checksum="DA059A3C13131961" modified="2017-01-18" version="1">MPAPPPGTALLAELRTEIARADSKAAVLVAALGVIVGVLGGLLTSTGWAPQQLSGAAKVLLALGGLGIAVSLVALLLAVLPRFRRSNWRPGRPLGYFGDIRLAAEQGLLADALADTERLAADAVRAALAENSLIVSRKHSWVRVGILSFGAGLFPLVTALFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAS5</accession>
    <name>A0A1E7NAS5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0024705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558090.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000665.1"/>
    </dbReference>
    <dbReference type="REBASE" id="196754">
        <property type="entry name" value="M1.SauDM1ORF3290P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78071">
        <property type="protein sequence ID" value="ARF78071"/>
        <property type="gene ID" value="B6264_03290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37795">
        <property type="protein sequence ID" value="OEV37795"/>
        <property type="gene ID" value="HS99_0024705"/>
    </dbReference>
    <dbReference type="OMA" id="HPFTPRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="44329" checksum="137257E1B5DD52A8" modified="2017-01-18" version="1">MPGFHSSSRDQIRILDLFSGGGGFAAGFRSFSRGNPGAAEFIPVAAVEFDRAAASTYAANFSSAHVHVGDIEGFDAWPLSGAVDVVVGGPPCQGFSQLGSGHAGDPRNRLWEDYLRFVTTIKPKVFVLENVDRFIKSDEFEEFLAATERGQPLGEYSLAFGVLNSADYGVPQSRRRTIVIGTHKDLTLVDLPRPSHTKSRRLLGKRADPALFSTSTGAGLKPWETVESVFHRSSRKKIQGTELPSRQAEVLPGIVVPGAYRTADLHVGRNPKPLSLARYAAIPPGGNRYDLRGKTALIDGRELALSTASWDNHNSGSADVMGRLRIDRPSVTIRTEFFKPEKGRYLHPFENRPITHYEAALIQGFPEDYQWYGTKLEIARQIGNAVPVGLGSAIAESIHNHLQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBB9</accession>
    <name>A0A1E7NBB9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000777.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79545">
        <property type="protein sequence ID" value="ARF79545"/>
        <property type="gene ID" value="B6264_12015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37990">
        <property type="protein sequence ID" value="OEV37990"/>
        <property type="gene ID" value="HS99_0024335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20850" checksum="72EB6321B7890392" modified="2017-01-18" version="1">MQSGGAELNLGCPGGFRSGASAAPDWWPVLAPDVTVDQLDAAEHCEALLRDTMGAVRPAPVWRETVPRAGVRLSAPGRREPEVLWYVTRGRDVLTVVSPGRRRELAAMVERQWRRRGWTITSLNAGRDRPGVAATTRYGSQLVLCFGEFGEIRLTASLLGVACSERVPALPGAGEPDPAALPHVHCSYWSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF5</accession>
    <name>A0A1E7NBF5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0024020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2075"/>
    <dbReference type="EnsemblBacteria" id="OEV38017">
        <property type="protein sequence ID" value="OEV38017"/>
        <property type="gene ID" value="HS99_0024020"/>
    </dbReference>
    <dbReference type="OMA" id="TDMVEQP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV38017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19268" checksum="CD0FF9A79A793DB1" modified="2017-01-18" version="1">MLIVGPDGLPVGQGFAGATMEGDDEADVPRELPVTEMVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRARLKDIHASSIKELELGLAPELVAELERLSLPFTEDSIPTEAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMRRALPPGSHGVDPDEEDPGQGRGIRSGPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR1</accession>
    <name>A0A1E7NBR1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557840.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7154"/>
    <dbReference type="EnsemblBacteria" id="ARF79660">
        <property type="protein sequence ID" value="ARF79660"/>
        <property type="gene ID" value="B6264_12755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38131">
        <property type="protein sequence ID" value="OEV38131"/>
        <property type="gene ID" value="HS99_0023340"/>
    </dbReference>
    <dbReference type="OMA" id="AWSFLIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="158" mass="16715" checksum="EF366D1D36D1F923" modified="2017-01-18" version="1">MPTGAADPSSNGRAPYEGERSVGQLFAAATADLSSLVHDEIALAKAEIKTDVKRGAAGSIFFVVAGVIGLAGIPMASIAIAFFFHWLGVPLGWSFAISFALHVFVAALVGFVAVRIFKKVTKPERTIEGVQKTAEVLKNARPRPATQEEIDRGLGRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC55</accession>
    <name>A0A1E7NC55_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1725"/>
    <dbReference type="EnsemblBacteria" id="ARF80214">
        <property type="protein sequence ID" value="ARF80214"/>
        <property type="gene ID" value="B6264_16005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38267">
        <property type="protein sequence ID" value="OEV38267"/>
        <property type="gene ID" value="HS99_0022265"/>
    </dbReference>
    <dbReference type="OMA" id="PGWTPRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="431" mass="46337" checksum="10254B571233C69B" modified="2017-01-18" version="1">MSDEAFSGTGPGVRFTAADEQKKRGVRRMKTIATGLLAFATLVFALSTWAKAAGAGAWAGYVAAAAEAGMVGALADWFAVTALFRRPFGLPIPHTAIIPTKKDAFGRSLGEFVGDNFLAGHVVRGRLAALGIGRRLGEWLAAPGSAERVTKEASAALRGLLAVLRDDDVRAVVAEAVTRRAAATSVAEPMGRMLGKVVADGGHRGVVDLVAVRAHGWLTANHEDVVRKVTQKTPGWTPKFLDQQVGERVYKELMRFVTDIRDDPDHPARGAIDNFLADFATELQTDPETIARVERAKGELLARPEVQDLINSTWAAVRTLVMGAAEDEDSELRRRIREGVRRFGERLATDAKLQAKVDGWLQDAAQYLVDTYRAEITSLISETVAGWDADEASRKIEANVGRDLQFIRINGTVVGALAGLLIHTVAVALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCA7</accession>
    <name>A0A1E7NCA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283993.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4150"/>
    <dbReference type="EnsemblBacteria" id="OEV38317">
        <property type="protein sequence ID" value="OEV38317"/>
        <property type="gene ID" value="HS99_0022605"/>
    </dbReference>
    <dbReference type="OMA" id="QTKERPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="9907" checksum="AF5BD6E2CF2B5A74" modified="2017-01-18" version="1">MSTLEPERGLGTGTLVEPVPQVSHGDGDHERFAHYVQKDKIMESALSGSPVVALCGKVWVPGRDPKKYPVCPMCKEIYDGIGKPQGGDGDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCB3</accession>
    <name>A0A1E7NCB3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553284.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4179"/>
    <dbReference type="EnsemblBacteria" id="ARF80184">
        <property type="protein sequence ID" value="ARF80184"/>
        <property type="gene ID" value="B6264_15820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38298">
        <property type="protein sequence ID" value="OEV38298"/>
        <property type="gene ID" value="HS99_0022450"/>
    </dbReference>
    <dbReference type="OMA" id="DWVVVTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16892" checksum="10CD8C4FC51492FC" modified="2017-01-18" version="1">MTSTEPRQQRRADVILYGAGGQVGRAVVAEARRRGLTVTAAVRDPGRAGVPRLLGVGVATTLQTAPGIAVHDDPAFPEAHRTFSLGHTAALDLLHASPATLDWVVVTPPMDLDRTAPGTGHYRVGGPHVLGSRIAQADLAVAIVDELTTPAHHREQISVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD5</accession>
    <name>A0A1E7NCD5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon proteolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4164"/>
    <dbReference type="EnsemblBacteria" id="ARF82856">
        <property type="protein sequence ID" value="ARF82856"/>
        <property type="gene ID" value="B6264_15740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38359">
        <property type="protein sequence ID" value="OEV38359"/>
        <property type="gene ID" value="HS99_0022530"/>
    </dbReference>
    <dbReference type="OMA" id="MPRDAVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="26946" checksum="FFD6BC792380C42B" modified="2017-01-18" version="1">MTKALKSPRTRALALCGVLIAALFGVAAFVPLPYTVTWPGLTADTLGSYRDKPVLTISGAPLRSTTGELRMVTITATNADQRTSLWRSLQAWFDSKEAVQPTEVVYPQSSPAKANEETAEQMAQSQDSATAAALGYLHLSPDQVKVKVDLGDVGGPSAGQMLALGIVDKLAGDGKGGDLTGGLTIAGTGTIDKDGTVGPVGGVPLKTQAAARDGATVFLVPKDECTDAKVNTPKTLRLVPVGTLAESVAALDALKSGGSVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCQ7</accession>
    <name>A0A1E7NCQ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene355"/>
    <dbReference type="EnsemblBacteria" id="OEV38472">
        <property type="protein sequence ID" value="OEV38472"/>
        <property type="gene ID" value="HS99_0021485"/>
    </dbReference>
    <dbReference type="OMA" id="DKAGQPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16377" checksum="964ABECD9C747B35" modified="2017-01-18" version="1">MEDQYLSLSEVETIARRAHEGQVDKNGHPYGEHIAAVAEGTAARGGSEAQIAAGWLHDTVEDGRLSREWLAGAALPEATKAIVDALTRRPEEPVEAYTARILATPGALLVKRADLAHNSDPSRLAALDRATAERLTAKYARMRELLGLTGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR3</accession>
    <name>A0A1E7NCR3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000579.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4208"/>
    <dbReference type="EnsemblBacteria" id="ARF80208">
        <property type="protein sequence ID" value="ARF80208"/>
        <property type="gene ID" value="B6264_15965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38273">
        <property type="protein sequence ID" value="OEV38273"/>
        <property type="gene ID" value="HS99_0022305"/>
    </dbReference>
    <dbReference type="OMA" id="DHTLGRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12204" checksum="1CBE222DB9C7A5E9" modified="2017-01-18" version="1">MGGASTQDKPERTAAQIEADIERTRERLAVNLDELAVRIHPSTISAQVKAKAMAAVEEKTAKAYVAASGLVEKARAQFVDEKGQPRKERIVPAALVGVGLVLLIASSRKRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDP8</accession>
    <name>A0A1E7NDP8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">HS99_0019390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000806.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6286"/>
    <dbReference type="EnsemblBacteria" id="ARF81236">
        <property type="protein sequence ID" value="ARF81236"/>
        <property type="gene ID" value="B6264_22125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38831">
        <property type="protein sequence ID" value="OEV38831"/>
        <property type="gene ID" value="HS99_0019390"/>
    </dbReference>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV38831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="24691" checksum="08B15DCA2A33F59D" modified="2017-01-18" version="1">MAQINPSILSADFARLADEAEAVRGSDWLHVDVMDNHFVPNLTLGIPVVESLARATDIPLDCHLMIEDPDRWAPQYVEAGAGSITFHVEAAAAPVRLAREIRAKGARASMALKPGTPIEPYEDLLPELDMLLIMTVEPGFGGQAFLDIMLPKIRRTRELIAKHDLELWLQVDGGVSAATIERCAEAGADVFVAGSAVYGAEDRAQAVRNLRELADKASADAWWACEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDZ6</accession>
    <name>A0A1E7NDZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290500.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6540"/>
    <dbReference type="EnsemblBacteria" id="OEV38936">
        <property type="protein sequence ID" value="OEV38936"/>
        <property type="gene ID" value="HS99_0019800"/>
    </dbReference>
    <dbReference type="OMA" id="CIARELW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15762" checksum="B831913A5C7413D5" modified="2017-01-18" version="1">MPLPQPDDDLTSLVLRTDFGDDEAWDALRTALDAADEYTHATYVSDLRFAGVSVRTLLDEEAAADEDDRVIHLFLADPTAMEGPEHPLLAVDLADEPGRTFRVPARWFPDVSANLSIANMDFAEFADAADRSGTFRGFEGTDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE92</accession>
    <name>A0A1E7NE92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557300.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4316"/>
    <dbReference type="EnsemblBacteria" id="ARF83181">
        <property type="protein sequence ID" value="ARF83181"/>
        <property type="gene ID" value="B6264_30005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38958">
        <property type="protein sequence ID" value="OEV38958"/>
        <property type="gene ID" value="HS99_0017745"/>
    </dbReference>
    <dbReference type="OMA" id="NTRIGME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16336" checksum="4759F72D6B096526" modified="2017-01-18" version="1">MTSDAPFPFGETSTLFIFTPTHGTTWNLTLDGFTQALRRKEGDKAFVHTKADGGAYGPSSEHDWWFDITAAGTSYEGIGSSASGDEGLCLRNATAGAAAEFAAWMLQEIVPPGAGVEFNTRIGMESGLDDEVLAVRTVTELEAVFREHLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB4</accession>
    <name>A0A1E7NEB4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4382"/>
    <dbReference type="EnsemblBacteria" id="ARF83242">
        <property type="protein sequence ID" value="ARF83242"/>
        <property type="gene ID" value="B6264_30345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39012">
        <property type="protein sequence ID" value="OEV39012"/>
        <property type="gene ID" value="HS99_0018075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14821" checksum="6192C8A9F7BDAAAB" modified="2017-01-18" version="1">MNRLLRFLPARLMRRLGYELALHDPAALAAALEANLDAARAGHDADLRAALRKMTSLLAFQPGLVDLHQESADIVVYLCSLAAAAEINLDLGNPGQYALYRELLDALRTAEDLRQRVAAAASLALPAAKSTPELQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEE6</accession>
    <name>A0A1E7NEE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557395.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000525.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4385"/>
    <dbReference type="EnsemblBacteria" id="ARF83245">
        <property type="protein sequence ID" value="ARF83245"/>
        <property type="gene ID" value="B6264_30360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39015">
        <property type="protein sequence ID" value="OEV39015"/>
        <property type="gene ID" value="HS99_0018090"/>
    </dbReference>
    <dbReference type="OMA" id="HEDANGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="11444" checksum="95B4CFEF2342E08E" modified="2017-01-18" version="1">MSTSTTWATAWPEGVLARYLTVGGAHVDLTTRRFTTNYTAQGRPYISDRWYEVDGFTWTCRGCDTRGSVNAFGDPYLPTERNKAHEDANGHAAACRSMARPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL0</accession>
    <name>A0A1E7NEL0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557128.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000469.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4068"/>
    <dbReference type="EnsemblBacteria" id="ARF83313">
        <property type="protein sequence ID" value="ARF83313"/>
        <property type="gene ID" value="B6264_30775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39078">
        <property type="protein sequence ID" value="OEV39078"/>
        <property type="gene ID" value="HS99_0018485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16384" checksum="087D250A3ECB341D" modified="2017-01-18" version="1">MKLNTIRKMVAAGALALGLVGVADTQAMATTYSSAFDGRYLYLTGSPVEGGGSACSSRQIYLAAGDYVWGMVTDQGDDTATIAGDGIYRSFDMNSPGVRSIYLAAGTYSWNDCITQHNGYYSMTSTLDAGYGPATLYASNIYLASGGYTVGSLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NES1</accession>
    <name>A0A1E7NES1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550132.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3510"/>
    <dbReference type="EnsemblBacteria" id="OEV39197">
        <property type="protein sequence ID" value="OEV39197"/>
        <property type="gene ID" value="HS99_0000240"/>
    </dbReference>
    <dbReference type="OMA" id="RTSWCQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="491" mass="55176" checksum="0701AF29F9200CCD" modified="2017-01-18" version="1">MSVVEQGVQCEPFAELSRFRGVFYDCLIGRRDALFELADAVLCTDGPVKTLVGLALAPEHRRGHGALYGALNRGRLDVERLRTELASLPLPRAADGRLVLAVDVSPWLRPDAATSDARSFCHTYGRGENKHLMIPGWPYSWVVALESGRTSWVAPLDAVRLRPGDDLAAVTASQLRDLVERLIAAGQWRPGDPAVWIVTDAGYDVMRLSWLLRDLPVEILGRLRSDRVMRRPAPTRAEFALANPAGGRPPKHGGEFIFKDSRTWGTPDAETKVETTRYGTAHAQSWDRLHPELQQRAAWRDHPGKLPVIEGTVIRLQVDHLPSGGDPKPLWLWWSRPTAGPAETDLAWQTFLRRFDIEHFFRMIKQTLGWTTPKLRDPEAADRWTWIMVAAHTQLRLARPLATDLRRPWEKPTEPNRLTPARVRRGFRHLRAKASTPATVPKPSRPGPGRPPGSKNRRPATRYDVGLLLATGESYRKPTHHKVGTKPRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX0</accession>
    <name>A0A1E7NEX0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3579"/>
    <dbReference type="EnsemblBacteria" id="OEV39249">
        <property type="protein sequence ID" value="OEV39249"/>
        <property type="gene ID" value="HS99_0000570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="18045" checksum="68D682B7AB566A68" modified="2017-01-18" version="1">MTIDLGFVWTALPGAGDVAFVDVPGHERLVTTMLAGVGPVPAVLFVVAADQGWQAQSEEHLAVLDALRVRHGVLAVTRSDLADPAPTREETLARLARSSLGRVEAVAVSSVTGVGLPELREALVRLTARLPAPDQAADGPASAHPADGEQAVADGDRPGRERAGDDGAVAPDGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ9</accession>
    <name>A0A1E7NEZ9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550206.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3601"/>
    <dbReference type="EnsemblBacteria" id="OEV39267">
        <property type="protein sequence ID" value="OEV39267"/>
        <property type="gene ID" value="HS99_0000680"/>
    </dbReference>
    <dbReference type="OMA" id="NIDAMSY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199072" evidence="1">
        <location>
            <begin position="29"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="32489" checksum="94608E7254C1582F" modified="2017-01-18" version="1">MPATTAPRRRTVLAAALAAAVTAGCSAGCSAGEGPARALRLATGPEGGPYNAFGRSFTETVTASGRLTLTPVSSAASVDNLQQLADGSVDLALTTADVAEDAVLGHDTFDHSLGVTALARVYVNYLHLLAPADGPVRELADLAGRRVATGAVGSGLQVTAARLLRQAGIGVRQHSLGLADSLAALRSGALDAVFWSGGVPTSAVSALARELPLRFVPLDAVAAQLRERYGPVYTGVTLPAGAYGLAGPVATLGVGNYLTARPGVPEDAVRQLLGILFDRWATLLRSVTAGARLEPRFAVSTGAVPLHPGAAAYYRSVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF47</accession>
    <name>A0A1E7NF47_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39302">
        <property type="protein sequence ID" value="OEV39302"/>
        <property type="gene ID" value="HS99_0000890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10394" checksum="D0575EBC35B08C10" modified="2017-01-18" version="1">MVGEEAGEAPALRGPVVGGDVEAAARQQVDHPVGRPAVAEDVDGEPPRRPVRHDQAVVTGPEGQGRRLTAAQCRPQPSDEVPVHRCPSRAAHSQRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF97</accession>
    <name>A0A1E7NF97_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288823.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1558"/>
    <dbReference type="EnsemblBacteria" id="OEV39380">
        <property type="protein sequence ID" value="OEV39380"/>
        <property type="gene ID" value="HS99_0001345"/>
    </dbReference>
    <dbReference type="OMA" id="MHTITSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22186" checksum="DE2436574E15EF4E" modified="2017-01-18" version="1">MTLTQPPTPQEAFEILLAGNQRFITGTVEHPNQDAARRSEIAPAQAPFAVLFGCSDSRLAAEIIFDRGLGDLFVVRNAGHVVGPETLGSIEYGISVLGCPLVVVLGHDACGAVAAARAAVSDGTTVRGYVRDVVERVTPSVLAARAAGRVEDADFIAEHVRHTVNLLMERSRALAHAVEAGSAAVVGLSYQLADGAVHLVTARGVEMAADAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD0</accession>
    <name>A0A1E7NFD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558136.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene552"/>
    <dbReference type="EnsemblBacteria" id="OEV39411">
        <property type="protein sequence ID" value="OEV39411"/>
        <property type="gene ID" value="HS99_0001545"/>
    </dbReference>
    <dbReference type="OMA" id="IKMRHIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015207">
        <property type="entry name" value="DUF1931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09123">
        <property type="entry name" value="DUF1931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16943" checksum="F66FC6D953F414BB" modified="2017-01-18" version="1">MTVMGVSKFERFFRAAAGLDVDKNELKRYGDFVDAKLYDLLVVGQASAKANGRDTVEPWDLPITKGLQESVHRFRRLDEEVELKPILEQLAVHPPLDRTPTQETEERYPEIIGGLSVALAETFKIMYPDIKNPQTSHWEGVTAVFDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFL6</accession>
    <name>A0A1E7NFL6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556250.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5063"/>
    <dbReference type="EnsemblBacteria" id="OEV39499">
        <property type="protein sequence ID" value="OEV39499"/>
        <property type="gene ID" value="HS99_0002060"/>
    </dbReference>
    <dbReference type="OMA" id="GFGFCPE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="259"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="507" mass="55440" checksum="B9071F2FD9CECFC9" modified="2017-01-18" version="1">MRQQPVLEVRGIRKEFPGVVALDGVDFRLFPGEVHALMGENGAGKSTLIKVLTGVHPADGGEVVLAGQRVRIAGPLQAQQAGISTVYQEVNLCPNLSVAENIFIGREPRRLGLIDWAEMRRRATELVCTLELDIDVSAPLDSYSIAVQQLVAIVRAVDVSAKVLILDEPTSSLDRDEVRQLFTVMRRLRDQGVAILFVSHFLDQIYEICDRMTVLRNGRLEGEYLTSELNQVELVSRMIGSELAGLDQLAGGKRRERSAPATDRAFLEAEGLARQGSVEPYDLAIRSGEVVGLAGLLGSGRTEAARLLFGADHKDRGTVRINGTETDLRSPRDAIAHGIAFCSENRKTEGLVGELTVRENIVLALQAARGWARPLSRTAQDKLALRWIGALDIRPGNPEALVRNLSGGNQQKVLLARWLITDPKLLILDEPTRGIDVGAKAEIQKLVADLAEKGMAVLFISAELEEVLRLSHRVGVLRDRRMVAQLRNDGELTPERVLATIASGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFP9</accession>
    <name>A0A1E7NFP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hydrogenase expression protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HS99_0000945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284891.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3655"/>
    <dbReference type="EnsemblBacteria" id="OEV39313">
        <property type="protein sequence ID" value="OEV39313"/>
        <property type="gene ID" value="HS99_0000945"/>
    </dbReference>
    <dbReference type="OMA" id="VPGCPIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="9">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="10">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV39313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="39107" checksum="8CCA668731DF04FE" modified="2017-01-18" version="1">MTIESGTTSTSGTPSRADQRQGFPEIDILWISEGLSCDGDTVSLTAADQPAIEDVVLGLIPGLPKVNLYNKVLSPTLGGEEFLAPYRAAARGESPNPFILVIEGSIPNQDIIEGDGYWTSFGNDLETGEPLTLNWWLDHLAPKAWAVVAAGTCATYGGIHAMAGNPTGAMGLADYLGWDFKSTGGLPIVNVPGCPIQPENFMETLTWVLYHAAGAAPPPPLDANLRPQWLFGRTVHEGCDRAGYYEQGNFAREYNSPKCQVKVGCWGPVVNCNVPKRGWMAGIGGCPNVGGICIGCTMPGFPDTFMPFMDEPSGGSLSPMLIKPYGAVIRRLRGITNMAVNREPRWRHRGSELTSGYDPHWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW5</accession>
    <name>A0A1E7NFW5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385406.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2733"/>
    <dbReference type="EnsemblBacteria" id="OEV39600">
        <property type="protein sequence ID" value="OEV39600"/>
        <property type="gene ID" value="HS99_0002695"/>
    </dbReference>
    <dbReference type="OMA" id="WLFAKET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025058">
        <property type="entry name" value="DUF3995"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13160">
        <property type="entry name" value="DUF3995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="16990" checksum="9735CD0B550C0B79" modified="2017-01-18" version="1">MKSTKISSRATAVGAVLAVDGLVHLYWATGRTWPVDGTTRLSQLVLNTQVPFTPQGLVPLAGMLFSGATLVLVRGGWLPALARRLPAVLPRWGSRAVACGLLARGAVGLVWVTGAWADPGDTFYWLNLALYTPLCLLLGRAAWQVSAAVTTAAGAAPTGAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG29</accession>
    <name>A0A1E7NG29_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285747.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6715"/>
    <dbReference type="EnsemblBacteria" id="OEV39575">
        <property type="protein sequence ID" value="OEV39575"/>
        <property type="gene ID" value="HS99_0002530"/>
    </dbReference>
    <dbReference type="OMA" id="AGACPLN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14355" checksum="AA1CCA6F0E65F132" modified="2017-01-18" version="1">MSSAVKLIRSTRLTPAVDYAYAAVVDAPARSLWLAGACPLDEEGRTVAVGDYEGQTHQVMRNLTTVLEDAGAGLTDIARTTVYVASSDQADLVKVWNVYREYLGEHDAPSTLLGVTVLGYTDQLVEVEAVAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG89</accession>
    <name>A0A1E7NG89_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnhA</name>
        <name evidence="8" type="ORF">HS99_0003415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279462.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2878"/>
    <dbReference type="EnsemblBacteria" id="OEV39720">
        <property type="protein sequence ID" value="OEV39720"/>
        <property type="gene ID" value="HS99_0003415"/>
    </dbReference>
    <dbReference type="OMA" id="GWGHPEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="232" mass="24083" checksum="1F7700047131A622" modified="2017-01-18" version="1">MVERVIAACDGAAKGNPGPAAWAYVVADGAGVPQRWEAGPLGHSTNNIGELTALQQLLSATDPAIPLEVRLDSTYTRDSVTKWLKGWKRNGWKTAAGKPVANRELIQRIDELLEGRDVTFVYVPAHQVDGDPLNAIADKAASDAARTQQAAAGTAADLPVPDPAAAAKAPKAPKARSTGSAATGAAKRSSGSRTLNARFPGTCPCSRPYAKGDKITKVGSSWGHPECATAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGE4</accession>
    <name>A0A1E7NGE4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550485.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2911"/>
    <dbReference type="EnsemblBacteria" id="OEV39742">
        <property type="protein sequence ID" value="OEV39742"/>
        <property type="gene ID" value="HS99_0003575"/>
    </dbReference>
    <dbReference type="OMA" id="YWGLPRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="41"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="30468" checksum="FAA03F0B12F3240E" modified="2017-01-18" version="1">MTEPVPVEAPTAWHGDALSESDWLVPLPPACSRALDGPREHPAPELAELATHVTRRVRNSRGFVVIRGLPVDGRTDQECAELCHRLAASLGTPWPAEPGGFITVADNAGLGRTNLALTPHTDRTPAPRPPKLLGLLSVRAAALGGDTLLASGHAVHNRLLTEAPWAIPRLYQDFHFGRGAGFDRIRPVFQRHGAELRVHYNRRGIERAHHEAGAPLTPDDHAALDAVDRILSDPRILLRIPLHPGDLLWLDNTAVLHGRTAFTDPPAPSAPRCLTRVWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGI2</accession>
    <name>A0A1E7NGI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386697.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3533"/>
    <dbReference type="EnsemblBacteria" id="OEV39787">
        <property type="protein sequence ID" value="OEV39787"/>
        <property type="gene ID" value="HS99_0000350"/>
    </dbReference>
    <dbReference type="OMA" id="WRVRLYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="855" mass="92013" checksum="6229F94F2E335912" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGK8</accession>
    <name>A0A1E7NGK8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550314.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000512.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2744"/>
    <dbReference type="EnsemblBacteria" id="OEV39851">
        <property type="protein sequence ID" value="OEV39851"/>
        <property type="gene ID" value="HS99_0002750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="162"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="35114" checksum="3C87723FC3AD7EFB" modified="2017-01-18" version="1">MLPFLCLLAAVLLLLLFARRFRDDRRRFGNGVLLGLCTVLVFAGSFLVLDRFHRPVAQAVAGATGVAAVAGATAVAGALMANGIRMVRAEGGRPANLLSPLAGLAVLAALALAVVAARTEHGPLRAAATAALLVAGYVGFLFLCFVGYAVLYQRVTARRPVDFVVVLGAGLADGSTVPPLLASRLQKALTLYRRQAAQGRPPTLVVSGGKGSDERVSEAEAMADYLMARGVPGTHILQESASTNTGENVAFSRELMERIRPGYRCAIVTNDFHSLRAAILARRAGVPGEAHGAPTAAYYRPSATLREFVAVLAAYPLTNLAVCAVLAAAGVRAGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVC2</accession>
    <name>A0A1E7MVC2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831108.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6971"/>
    <dbReference type="EnsemblBacteria" id="OEV32377">
        <property type="protein sequence ID" value="OEV32377"/>
        <property type="gene ID" value="HS99_0016905"/>
    </dbReference>
    <dbReference type="OMA" id="QVDHIDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="23540" checksum="F3D98EDC26AA664B" modified="2017-01-18" version="1">MNQPSDPDPTAVARRVAERRERLGLSEEDLAHRAAMAPRYLAHLLEAGPVFDPGGFVRIAAALGATRDELLADGPDTPPGLGGPGPRPRLLHLTDAECWELVGSHGIGRIALPVRPGPAVHPVNYVVDRASFAYRTGDRTGTAPEEGAEVSLEVDRIDEFQGRGWTVLVIGPARYVDDPEERRHLDGLPGAAPWAGGDRPRWVRIRPAEISGRRLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP8</accession>
    <name>A0A1E7MVP8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290188.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000679.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32498">
        <property type="protein sequence ID" value="OEV32498"/>
        <property type="gene ID" value="HS99_0017625"/>
    </dbReference>
    <dbReference type="OMA" id="THQPDTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="21998" checksum="32D525780E73F702" modified="2017-01-18" version="1">MFVTTGQAGTALGCSIPTVKKLMATGVVPGVREQGRQVFPLAALQALQARPAAGLTVLSAPEIAVLRSDAPTRVDEPDRDWIGFGTALDRAQLLAALSGWWRCDPARVAAGAVLPVTVAGFVVAVLTGLTEWEGDGTVGTAARFRFPKARLAGYLTDLTAPANAATPTDPQDARLAGLLLGTRLASVSGGPIAYVPTNPTTTHQPDTEGGMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS6</accession>
    <name>A0A1E7MVS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481772.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000287.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7513"/>
    <dbReference type="EnsemblBacteria" id="OEV32528">
        <property type="protein sequence ID" value="OEV32528"/>
        <property type="gene ID" value="HS99_0017215"/>
    </dbReference>
    <dbReference type="OMA" id="HGGGPNW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24375" checksum="4613085C4B1EC22A" modified="2017-01-18" version="1">MALVYRGPAACDGCPEAAHDMLETDGFTVRYIGPDEQARFGPDALSGAALYVQPGGTNGQEVSTAWSLLQRDPGFSPELVRSYVRGGGHYLGLCMGGYLAGSEPGYGLLPGDSGQYISSRNAAVTDEQDHLLDVLWRGQPQKMYFQDGPYFDVDGPGAEVLARYTNGRAAAVVASYGAGRIAVSGPHPEAPSEWYRDYKLPNESQTGLALGKDLLNTLMATAPAATAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVU1</accession>
    <name>A0A1E7MVU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0040120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000090">
        <property type="protein sequence ID" value="OEV32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557617.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000128.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7120"/>
    <dbReference type="EnsemblBacteria" id="OEV32557">
        <property type="protein sequence ID" value="OEV32557"/>
        <property type="gene ID" value="HS99_0040120"/>
    </dbReference>
    <dbReference type="OMA" id="YDTADIA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="179"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="26735" checksum="7933E90BA2FC3DC7" modified="2017-01-18" version="1">MTSTEAPRGEAATTHRPPVVPRSGSARPAAPRIPVQKRRPAQIPVAVYAEDVILQTGVVQQLRQRPEVELLSEDEAGRAEVSLLVVDALTEAVAENLRRLRLATSGRIGLVVGQFEAGGLQTIVECGVAAVLRRSEADQDRLVHLVTALANGEGVMPGDLLGELLDRIGMLQRTMLDGRGLTLSTLTARETEMLRLVAEGFDTSEIAAKTSYSERTVKNVLHEIITRLRLRNRAHAVGYAMRRGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVZ7</accession>
    <name>A0A1E7MVZ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287915.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3824"/>
    <dbReference type="EnsemblBacteria" id="ARF78355">
        <property type="protein sequence ID" value="ARF78355"/>
        <property type="gene ID" value="B6264_04960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32605">
        <property type="protein sequence ID" value="OEV32605"/>
        <property type="gene ID" value="HS99_0015120"/>
    </dbReference>
    <dbReference type="OMA" id="VHDIYPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="46641" checksum="BD1AF9458A2CA373" modified="2017-01-18" version="1">MDGVPQRPRRGLTPATTQQEFLRRFVLALRYLLEVGGTAVVAFLGFYALLAVFVLSLVGPGLSLLPLSLARLRRVADAHRRRAGQWLDCEIPSSYREAEGRVLVRAQAMLTDKATYTDLLWLLLHAVLGTLGAALAIGLCVGSASWLTIPLWWQVVPKPAQFLVWNIDSWGSALGACFAGLAYGALAGWLLPWCAQLHALMTRALLKPRKRRTSLAKRVEELTITRAEALEAHAAELRRIERDLHDGAQAGLVSVSLRLALMKRVLHDNPEKLPEMIDQARDLADQAVQSLRVAVRSIYPPVLADHGLAEATRSLVAACQIPTKLDLEYESRSSRAPAAVEAAAYYVISEALTNVAKHSGAECSQVQLRTTESRIHISVWDDGQGGAATTGSGSGIRGIKRRVAAFDGVTELHSPPGGPTVLRVELPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW61</accession>
    <name>A0A1E7MW61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386072.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3167"/>
    <dbReference type="EnsemblBacteria" id="ARF78285">
        <property type="protein sequence ID" value="ARF78285"/>
        <property type="gene ID" value="B6264_04570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32677">
        <property type="protein sequence ID" value="OEV32677"/>
        <property type="gene ID" value="HS99_0015515"/>
    </dbReference>
    <dbReference type="OMA" id="PFRRWVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="26216" checksum="709BA7DC32134A05" modified="2017-01-18" version="1">MTDPQSAAAVAAERLSLVESSTRRMLETVAELKPDAVTEPSALPGWTRGHVLAHLARNADSLVNLLTGARTGTDIPQYASEEEREQGIQDGAGRPLEEQLADLRESHERFLAAVALMNDEDWAAEVRHRSGAVFPACDLVWKRLGELEYHLVDLDGGYSPASWPEPFAVAEFHSLALRLHGTDLPAVELVAEDTGDRGLIGSGPVSLTVQGPVRALLAWLSGRSGGADLRRNPDTALPQLPPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWL1</accession>
    <name>A0A1E7MWL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000127.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1992"/>
    <dbReference type="EnsemblBacteria" id="ARF79564">
        <property type="protein sequence ID" value="ARF79564"/>
        <property type="gene ID" value="B6264_12130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32820">
        <property type="protein sequence ID" value="OEV32820"/>
        <property type="gene ID" value="HS99_0039970"/>
    </dbReference>
    <dbReference type="OMA" id="IESEGHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="29941" checksum="AA9EF753D24F3FCF" modified="2017-01-18" version="1">MLNIGDFASHGRVSVRMLRHYDAIGLLRPARVDPVTGYRSYEAGQLARLNRVIALKELGFTLQQVRAVLDERPDAAELRGMLRLRRAQLAAAIAADEQRLARVEARLRTIESEGNMSEHDVVVKPVPSVRVAQLTGVAASYQPEDITPVIGPLFAELCSRVAGAGIEEVGPSVAHYEDSPEGDGSVLVRAAVQVPHSVPGGRDDFEVLDLPPIAEAATIVHRGSMDAAMGSFQALARFIGENGYRSAGYARERYLETPDDLSGWVVELQEPVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWQ8</accession>
    <name>A0A1E7MWQ8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000080">
        <property type="protein sequence ID" value="OEV32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558327.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000351.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83362">
        <property type="protein sequence ID" value="ARF83362"/>
        <property type="gene ID" value="B6264_31070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32875">
        <property type="protein sequence ID" value="OEV32875"/>
        <property type="gene ID" value="HS99_0039700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11581" checksum="D5A5B2D1E8CC48C0" modified="2017-01-18" version="1">MSRACPPRLRSTLGWRELRAHALALDELIGGALHAGQALPGAHCIAAADFQQLTRELVRCAVIADREAGATWATIGEALGLSADAARARYGNVRLLWPPPVGVRVHVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV5</accession>
    <name>A0A1E7MWV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290871.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5789"/>
    <dbReference type="EnsemblBacteria" id="ARF81335">
        <property type="protein sequence ID" value="ARF81335"/>
        <property type="gene ID" value="B6264_22675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32925">
        <property type="protein sequence ID" value="OEV32925"/>
        <property type="gene ID" value="HS99_0013655"/>
    </dbReference>
    <dbReference type="OMA" id="APGPHWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="36677" checksum="9B4A4D636D6F5A8C" modified="2017-01-18" version="1">MPNDPRSHLTGDVLAVVSQSGATVSFFDAATDALLDTLEVTAEPHELCFDPTRRLLWCTTAYHSGYYHAHSGRSTKLTVIDADTRRIVEVIDLAPEHGPHGLALDLDRDRLYVSVEASADRPGGVVVVDLATRRPLGRIDTDAPGPHWFAISPDGRTGYATNKEAPFVSVVDLGRGVLTAKVEVPGSEGLAVSPDGSRVYVAAPYLGFAGKPDAEPGIHVIDTRTASVVEVLPTGSAVIPVHLTATGRLLTGEISATPGTDSPLGRQDPGRLTVFSAATHRPLGSLEVGQFPLTITSSPDGRFGYVSCVVSSTVDVVDLTTLTPVSRLTVPKTAEPGAHGLAYLPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX46</accession>
    <name>A0A1E7MX46_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">HS99_0016040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000786.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6111"/>
    <dbReference type="EnsemblBacteria" id="OEV32813">
        <property type="protein sequence ID" value="OEV32813"/>
        <property type="gene ID" value="HS99_0016040"/>
    </dbReference>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="33151" checksum="94F73C2379AA7E54" modified="2017-01-18" version="1">MTRAAAFALGAVAGYAADARFADPRRGHPVALFGSAATRLERRVWRDDRAAGAGYTALCVGAVAAGALALDRTVGHRPLGRAALAAAATWTVLGGTSLTREARTIGRSLAAGDLTAARERLPHLCGRDPGALDGQQIARAVVESVAENTADAVVNALTWGTLAGTPGLLAFRAVNTLDAMVGHRSPRYGRFGWASARLDDVAGWPGARLTALLTVAAAPEPRTAWRVWRRDGSAHPSPNAGQAESAFAGAVGVRLGGTLTYGKRVEHRPVLGGELRPVTVDDIERACTLSRRVGALALGTTVAGHVLLRALFGKRRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX81</accession>
    <name>A0A1E7MX81_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552456.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000857.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81440">
        <property type="protein sequence ID" value="ARF81440"/>
        <property type="gene ID" value="B6264_23245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33024">
        <property type="protein sequence ID" value="OEV33024"/>
        <property type="gene ID" value="HS99_0014215"/>
    </dbReference>
    <dbReference type="OMA" id="WHYTGGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20482" checksum="32611270BC814E30" modified="2017-01-18" version="1">MDDFAGTQAPVRRMTDPIEIVGELESAVPGLAELRLPKPSSISRQVVEADLGVALPADSRLLCELYPPFVLGDFLGVGGPDPGGEHSWVQGTRETLEIIAEWCEEAEPAVPLHAHPAPGGLPPWADSNRGDFFLWTTNPARPQDWTVTVASRSSARWHYTGGAVQFLADLVSGAVEPWALPTIRPSVVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ2</accession>
    <name>A0A1E7MXJ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3421"/>
    <dbReference type="EnsemblBacteria" id="OEV33170">
        <property type="protein sequence ID" value="OEV33170"/>
        <property type="gene ID" value="HS99_0014705"/>
    </dbReference>
    <dbReference type="OMA" id="EWFLVGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="791" mass="84875" checksum="082D54D56C51D435" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY17</accession>
    <name>A0A1E7MY17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antibiotic biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283882.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3404"/>
    <dbReference type="EnsemblBacteria" id="ARF80441">
        <property type="protein sequence ID" value="ARF80441"/>
        <property type="gene ID" value="B6264_17375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33340">
        <property type="protein sequence ID" value="OEV33340"/>
        <property type="gene ID" value="HS99_0012145"/>
    </dbReference>
    <dbReference type="OMA" id="DHMVHFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11771" checksum="541B9B3D0729396E" modified="2017-01-18" version="1">MILESALLDVLPGREDEFLAAFAEARPLIAVQRGFRTLRLHRCLDEGRGSRFLLQVEWETLADHTEGFRGSAEYGRWRELLHRFYRPFPEVEHYGEPVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA8</accession>
    <name>A0A1E7MYA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0012530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287588.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3984"/>
    <dbReference type="EnsemblBacteria" id="ARF80505">
        <property type="protein sequence ID" value="ARF80505"/>
        <property type="gene ID" value="B6264_17755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33401">
        <property type="protein sequence ID" value="OEV33401"/>
        <property type="gene ID" value="HS99_0012530"/>
    </dbReference>
    <dbReference type="OMA" id="HRYPVAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23780" checksum="B1F083E73A19070B" modified="2017-01-18" version="1">MDLPVNLPEKLYLLAHDPRRGRTTQHSSLNLLLQAAALTELLRRGLLYEEGRKAVARVRGGAAEDGLDPYSARLLGRIRESRPHSWSTWVGRARSTGRDQPIRWVRDGLADAGRITLRPHRVAGLFPVTLVTLDDPGAREALAAAVAGALKGPLSRVDPADAALTALVAAGRLRSVLSARQRREHRARIAKLAPAAGPVPRALGRALAWQMAGHAAQSAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYY7</accession>
    <name>A0A1E7MYY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553137.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4933"/>
    <dbReference type="EnsemblBacteria" id="ARF80002">
        <property type="protein sequence ID" value="ARF80002"/>
        <property type="gene ID" value="B6264_14760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33665">
        <property type="protein sequence ID" value="OEV33665"/>
        <property type="gene ID" value="HS99_0038430"/>
    </dbReference>
    <dbReference type="OMA" id="YEDAHTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="578" mass="60285" checksum="0D245DD42DD5866A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ44</accession>
    <name>A0A1E7MZ44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289894.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000421.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4303"/>
    <dbReference type="EnsemblBacteria" id="ARF80342">
        <property type="protein sequence ID" value="ARF80342"/>
        <property type="gene ID" value="B6264_16770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33681">
        <property type="protein sequence ID" value="OEV33681"/>
        <property type="gene ID" value="HS99_0038300"/>
    </dbReference>
    <dbReference type="OMA" id="TGRPQAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26927" checksum="373349889DEAF28A" modified="2017-01-18" version="1">MAYQTYPAPGPQPGTEQRRTRPRILPGFGLRGPRREKHVLEAADLAALAFPVGDDGVVIGVDPQGLPAVLGLFRPSSYDLVLVGGIWTAQVIALRAAAIGARVAVETARAQLWGPMAQAAGGGQPCVTIHQVGRLGPQGASVASPVLVVRDLGARPPRSRLSAAPWQTTLTLLPYLGPNASRVLNAADLVGVQRISPQEAELTGRVLSLPSEDVAALPTLGDDLTLWATRMRRQYVRAVAGQAEQQVLGGPRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ84</accession>
    <name>A0A1E7MZ84_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1916"/>
    <dbReference type="EnsemblBacteria" id="OEV33729">
        <property type="protein sequence ID" value="OEV33729"/>
        <property type="gene ID" value="HS99_0038265"/>
    </dbReference>
    <dbReference type="OMA" id="HAYMDSG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="491" mass="53881" checksum="1B0AD4AA7EC1CF88" modified="2017-01-18" version="1">MTSGSDVWSFASAPKLHPMRVTVTTRQPGTARGDVFVAPYNLTQPVGQTGALMLEDSGDPVWFRPLPVANLENGDFRVQTYHNPRTGVTQPVLTFWQGTIAIPPYYTNLPGGAPEPGGCYYIYDDHYRLLRTVFARHGFYPDFHEFLLTRRGTALFIASKPVPMDLTPYGGPKNGAIEDSEVQEVDLATGRLVFSWDILDHVNPADSEVSASSASSSGGVWDAYHVNSIDEGPDGQLLISARNLWAVYDVARQTGDIRWQLGGKRSDFSFGPNADFYWQHHARFRPGNRISMFDDGCCNQPDGTPEQQSHGLILNLDFPNHRATAARTYYHAPGLYAASQGDTQALTNGNEFVGWGQESYYSEYRGAGNTEGDGSKNLLYDAMMPGSDISYRAFRHEWVGKPWYPPSAAARDGSGGRSTVYASWNGSTETRAWQVLAGPDARSLSVVVDHADRTGFETAVTTDNPGPYFQVRALNAKGEVIGTSHVVTRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N039</accession>
    <name>A0A1E7N039_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551818.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2296"/>
    <dbReference type="EnsemblBacteria" id="ARF77903">
        <property type="protein sequence ID" value="ARF77903"/>
        <property type="gene ID" value="B6264_02275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34046">
        <property type="protein sequence ID" value="OEV34046"/>
        <property type="gene ID" value="HS99_0011425"/>
    </dbReference>
    <dbReference type="OMA" id="HYAASTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27368" checksum="F7C9535C18785BE9" modified="2017-01-18" version="1">MLSVVVAPWAGEAEPVFMRAPDELHDAASTMKIAVLAALTRSGANLDAEVPVVNRFESVVGGDFGNDPDWDSDPLPWELLGTHVPLRLLAERMITHSSNLATNLCLGRTDQRAVAEVWRQAGATHSASPRGIEDYAARAAGIHNRVSARDLVRLLHSLADEPELLGLLERNDFRVDLAAGLPPGTRIAFKNGWIPGARHCVGLVHPYDCPPYLIAVCYTGPLASGADRGDPAARLLARVSAAVWKRREEITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N058</accession>
    <name>A0A1E7N058_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0011535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551845.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2317"/>
    <dbReference type="EnsemblBacteria" id="ARF77922">
        <property type="protein sequence ID" value="ARF77922"/>
        <property type="gene ID" value="B6264_02385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34064">
        <property type="protein sequence ID" value="OEV34064"/>
        <property type="gene ID" value="HS99_0011535"/>
    </dbReference>
    <dbReference type="OMA" id="GVMTIMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052591">
        <property type="term" value="F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="518" mass="53682" checksum="B32D4E5E122E3189" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N083</accession>
    <name>A0A1E7N083_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="5" type="ORF">HS99_0011740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551897.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2361"/>
    <dbReference type="EnsemblBacteria" id="ARF77960">
        <property type="protein sequence ID" value="ARF77960"/>
        <property type="gene ID" value="B6264_02595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34100">
        <property type="protein sequence ID" value="OEV34100"/>
        <property type="gene ID" value="HS99_0011740"/>
    </dbReference>
    <dbReference type="OMA" id="GYMRKFK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11321" checksum="3A9FE86D48FE390B" modified="2017-01-18" version="1">MAKQSKIAKNEQRRVVVARHAERRPELKRTITSPAGSPAERAAAQAELQRQPRDASATRVRNRDSVDGRPRGYLRAFGLSRINLRTLAHAGQLPGVRRSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N4</accession>
    <name>A0A1E7N0N4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6068"/>
    <dbReference type="EnsemblBacteria" id="ARF78158">
        <property type="protein sequence ID" value="ARF78158"/>
        <property type="gene ID" value="B6264_03825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34242">
        <property type="protein sequence ID" value="OEV34242"/>
        <property type="gene ID" value="HS99_0036925"/>
    </dbReference>
    <dbReference type="OMA" id="GTTWVQM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="535" mass="55363" checksum="573597DAF1AFF50F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0P6</accession>
    <name>A0A1E7N0P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0036870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830044.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6057"/>
    <dbReference type="EnsemblBacteria" id="ARF82603">
        <property type="protein sequence ID" value="ARF82603"/>
        <property type="gene ID" value="B6264_03770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34259">
        <property type="protein sequence ID" value="OEV34259"/>
        <property type="gene ID" value="HS99_0036870"/>
    </dbReference>
    <dbReference type="OMA" id="RDPLAWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="43868" checksum="45DED7A6162236DC" modified="2017-01-18" version="1">MPPAADTTASPRTGARPQTERPSAPAKYLGVLFAVAIAAAAVNLRPVVTSLGPLLDPVRADLGMSSTLAGLLAAVPALCFALFGFLAPAAARRIGPIAVITAGMGAITAGVLARSFAGGTAVFLLLTALALAGVAVSNVLLPVVIKRYFPEKVGPMIGLYSMALSAGTALAALVSVPLTSALGGDWRYGLGVWAGLGALALVLWLPVLIAKRERGERAGSAGAPAKLPITRSRTAWAMAGYFGLQATGAYVVMGFLSKIFQDSGIDKGTSGALLAVTMVIGVPVSFVLPNLAARRGDQRLFVVVLASFGIAGYAGLAFAPAGAPWVWAVLVGLSNCAFPLVLTMIGLRARTAGGVAQLSVFAQGVGYLISIPGPILVGWIYQATGRWYGPLGFLALLLVPQMLFGLRAARARHIEDEAVHHAERVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U5</accession>
    <name>A0A1E7N0U5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290909.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1901"/>
    <dbReference type="EnsemblBacteria" id="OEV34309">
        <property type="protein sequence ID" value="OEV34309"/>
        <property type="gene ID" value="HS99_0036560"/>
    </dbReference>
    <dbReference type="OMA" id="LPFWHGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1555" mass="166020" checksum="764A38C20F6D8B7B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W2</accession>
    <name>A0A1E7N0W2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="9" type="ORF">HS99_0036655</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386351.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7649"/>
    <dbReference type="EnsemblBacteria" id="ARF82650">
        <property type="protein sequence ID" value="ARF82650"/>
        <property type="gene ID" value="B6264_05725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34315">
        <property type="protein sequence ID" value="OEV34315"/>
        <property type="gene ID" value="HS99_0036655"/>
    </dbReference>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="32162" checksum="5377293039CAF122" modified="2017-01-18" version="1">MSASSPQQSSSQRAGLPFFKGHGTQNDFVIVPDPDGVLEIGPETVAALCDRRAGIGGDGLLRVVRAAADPAAADLADRAEWFMDYRNSDGSIAEMCGNGLRVFARFLVEAGLAKPGELAIATRSGVLTAKVAEDAEDGTPGEVTVGMGRARLPGPDGIEVAVGERRWPALNVNMGNPHAVAFVESLDHAGDLFTAPLTSPEGAYPEGVNVEFVVDRGPRHVAMRVHERGSGETRSCGTGACAVAVAAIRRDGADPAVTGEAVSYTVDVLGGRLVITEHPDGRVEMTGPAVIVAEGRLDERWWGSLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Z5</accession>
    <name>A0A1E7N0Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0036120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553514.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3902"/>
    <dbReference type="EnsemblBacteria" id="OEV34354">
        <property type="protein sequence ID" value="OEV34354"/>
        <property type="gene ID" value="HS99_0036120"/>
    </dbReference>
    <dbReference type="OMA" id="TERLPMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="9">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="456"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="509" mass="53783" checksum="A6CC92247F514B6B" modified="2017-01-18" version="1">MTTSTTAGSSPAPLLDLQALVVAVRRRRRLWCSLALLGLLLGAAVAFLRPPPPTAATKVLVAHQADQPNDPGTLIRTDVALLQTTEIADQALKSLGSPDRTEDFMRTYGGTGLTNNLLQITVTGRSEAEAVARAEALADAFVADHVKRIKDAADAEAKALLDQRDRLRDQLAQVNQSIGDAAKQTGPNASANLESLYANRAELASRITDFGQRAAEAQVGTPRLVAGTRIVDAPRAVRQSLPTTAATDAAIGLVLGLVLGIAVAAVGAVVADRPVLRREIAANLGASVIAELRRVPRHPAGRWRLRRTRAARARLTTTLARTVRGCAEAVSLLELGCAHSTGAIALDLAGALAEEGPVVVVDGLPGSRLSRRRPGPDGPTVVVDGERAGALPPGQRRLGVGSVAPGTAWTDLGHLGTRTVLVVRAGHGSAAWLHTVARQLADQRIPVLGVVLIDPDPRDRTDGTLWDGPHTAPRGRNGPQARQNRTGRRRTERLPMWTARVPDNDQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N183</accession>
    <name>A0A1E7N183_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555347.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1414"/>
    <dbReference type="EnsemblBacteria" id="ARF82745">
        <property type="protein sequence ID" value="ARF82745"/>
        <property type="gene ID" value="B6264_10200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34436">
        <property type="protein sequence ID" value="OEV34436"/>
        <property type="gene ID" value="HS99_0036020"/>
    </dbReference>
    <dbReference type="OMA" id="CGLANIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="245" mass="24831" checksum="9135D7CA17B294F3" modified="2017-01-18" version="1">MVEGKAAVVTGGSRGIGRAIVERLAREGADVVLGYANDRAAAEAVVGAVAAAGGRAWAVRADLGESGAAEQLMAAAEERLGGLDILVNNAAKSFTPTPLADLDDAAFDAVLSVNTRAVLATVRYAARRMRDSGRIVNISSVNTARAVPGIGAYAASKGAVEQLTAVAAAELGPRGITVNTVSPGATDTDLLRGTNPPEALERVAGLTPLRRLGQPEDIADVVAFLAGPDARWITGQNLRATGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A2</accession>
    <name>A0A1E7N1A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290803.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000308.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1057"/>
    <dbReference type="EnsemblBacteria" id="ARF78945">
        <property type="protein sequence ID" value="ARF78945"/>
        <property type="gene ID" value="B6264_08460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34456">
        <property type="protein sequence ID" value="OEV34456"/>
        <property type="gene ID" value="HS99_0035735"/>
    </dbReference>
    <dbReference type="OMA" id="RDWAGMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="433" mass="47891" checksum="F94949E51520419E" modified="2017-01-18" version="1">MPAQPDGVQPAAQSAPQLFTWEFAADPYPAYAWLREHAPVHRTKLPSGVEAWLVTRYADARQALADSRLSKNPAHHSEQAHRTGRVGIPGERQADLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFEPRVQQLTDRLIDGFAQRGSADLIHEFAFPLPIYAICDMLGVPAEDQDDFRDWAGMMIRHGGGQRGGVGRAVKRMRAYLLELIHRKRADLGDDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGTYALLRNPEQRALLQESVVRGETALLETGIEELLRYDGPVELATWRFATAPLTVGGVEIPVGDPVLVVLAAADRDPARFADENTLDLARSDNPHLGFGHGIHYCIGAPLARLEGRSALATLLSRLPDLRLAESPENLRWRGGLIMRGLRELPVEFSPEPRSPHVLPEPPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1P1</accession>
    <name>A0A1E7N1P1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558224.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000656.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7499"/>
    <dbReference type="EnsemblBacteria" id="ARF77533">
        <property type="protein sequence ID" value="ARF77533"/>
        <property type="gene ID" value="B6264_00070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34585">
        <property type="protein sequence ID" value="OEV34585"/>
        <property type="gene ID" value="HS99_0008770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="19543" checksum="6A4CB581E0EEFEC2" modified="2017-01-18" version="1">MKIQNRITVLAATFLSCAGMVTLATGASAAVPTPDSTAGVSARVTAAAAASSYHTIKNMAYSQCVDAPGGVLNVRLQLANCNGSSTQNWAFVSAGSADTYYLVNQASGYCAEVNNGTSVPGEAVDEYLCDGLASEQWVETAVIVDQKIGAKFRHVGTNLCLDTVGGAGSQLIQWSCGDARPAAAQVWIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y6</accession>
    <name>A0A1E7N1Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000126_gene7220"/>
    <dbReference type="EnsemblBacteria" id="OEV34686">
        <property type="protein sequence ID" value="OEV34686"/>
        <property type="gene ID" value="HS99_0009360"/>
    </dbReference>
    <dbReference type="OMA" id="RRWTSWH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="31"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="430" mass="47788" checksum="65FB4E1F0378148C" modified="2017-01-18" version="1">MAVGASVDPARWQSVFEGLMARVAGRFARVEPRRRARAFVLGLLADLPRKNCWTIAEHAGDASPAGMQHLLSRASWDADHVRDDIRDFVVDHLADEGAVLVVDETGDLKKGTASVGVQRQYTGTAGRIENSQVAVYLVYSSPAGHAAIDRRLYIPRSWTQDPDRCRAAGVPEGLGFATKPALATEMIAQALDADVPAAWVTGDEVYGGDPHLSAELERRQIGYVLAVSRKRPITTCAGVFRAGVLAHGLPKNAWQRLSAGAGAKGHRFYDWAQVDIDSPQDSGGHWWLLIRRNRRTGAFYRCYSAHPVPLTTLVKVAGRRWTVEETFQAAKGLAGLDEHQVRRWTSWHRWTTLAMLAHAFLAVTAAIEQAATRPPGFVPLTCSEIRRLFAAFITPPIRNLAHRLRWSDWRRRHQARARTSHYRRQAAQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D3</accession>
    <name>A0A1E7N2D3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557765.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7625"/>
    <dbReference type="EnsemblBacteria" id="ARF81803">
        <property type="protein sequence ID" value="ARF81803"/>
        <property type="gene ID" value="B6264_25490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34836">
        <property type="protein sequence ID" value="OEV34836"/>
        <property type="gene ID" value="HS99_0010235"/>
    </dbReference>
    <dbReference type="OMA" id="KMGAAYI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="744" mass="77954" checksum="7315808414105FAF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G8</accession>
    <name>A0A1E7N2G8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81981">
        <property type="protein sequence ID" value="ARF81981"/>
        <property type="gene ID" value="B6264_26630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34653">
        <property type="protein sequence ID" value="OEV34653"/>
        <property type="gene ID" value="HS99_0009150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9335" checksum="8004E41015D8CBD4" modified="2017-01-18" version="1">MMVDGLPRWSPMSTVRLPAQPGLLVVHVAYPVPDMPGTPGLVTACGIDTASMVKHPWQPFAPGSRWYPPYLALCVCSRCDRAVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q6</accession>
    <name>A0A1E7N2Q6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290419.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4566"/>
    <dbReference type="EnsemblBacteria" id="ARF78519">
        <property type="protein sequence ID" value="ARF78519"/>
        <property type="gene ID" value="B6264_05975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34978">
        <property type="protein sequence ID" value="OEV34978"/>
        <property type="gene ID" value="HS99_0034785"/>
    </dbReference>
    <dbReference type="OMA" id="REGLNQH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="464" mass="51044" checksum="9A0B85754A1B99C3" modified="2017-01-18" version="1">MTADPAQKDLSKTAYDHLWMHFTRMSSYENSPVPTIVKGEGTYIWDDKGRKYIDGLAGLFVVQAGHGRTELAEVAAKQAKELAFFPIWSYAHPKAVELAERLANYAPGDLNKVFFSTGGGEAVETAWKLAKQYFKLIGKPTKYKVISRAIAYHGTPQGALSITGLPGLKAPFEPLVPGTHKAPNTNIYRAPHYLEGPDGTVDPEAYGRWCADQVEEAILFEGPETVAAVFVEPVQNAGGCFPPPPGYFQRLREICDRHDVLLVSDEVICAFGRLGTMFGADKFGYVPDMITCAKGMTSGYSPIGATIISDRIAEPFYKGDNTFLHGYTFAGHPVSSAVALANLDIFEREGLNQHVLDNESAFLGTLSKLRDLPIVGDVRGNGYFYGIELVKDKVTKETFNDEETERVLYGFLSKALFDNGLYCRADDRGDPVVQLAPPLISDQSTFDEIEQILRTSLTDAWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N326</accession>
    <name>A0A1E7N326_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000600.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene402"/>
    <dbReference type="EnsemblBacteria" id="ARF78901">
        <property type="protein sequence ID" value="ARF78901"/>
        <property type="gene ID" value="B6264_08210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35098">
        <property type="protein sequence ID" value="OEV35098"/>
        <property type="gene ID" value="HS99_0034120"/>
    </dbReference>
    <dbReference type="OMA" id="RASHEGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="535" mass="56530" checksum="F28F0C8769379C2D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N378</accession>
    <name>A0A1E7N378_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285406.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4449"/>
    <dbReference type="EnsemblBacteria" id="ARF78447">
        <property type="protein sequence ID" value="ARF78447"/>
        <property type="gene ID" value="B6264_05510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35151">
        <property type="protein sequence ID" value="OEV35151"/>
        <property type="gene ID" value="HS99_0033745"/>
    </dbReference>
    <dbReference type="OMA" id="NTWEVDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="703" mass="77379" checksum="790E99388FEC1B62" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3C3</accession>
    <name>A0A1E7N3C3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289807.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1392"/>
    <dbReference type="EnsemblBacteria" id="ARF79257">
        <property type="protein sequence ID" value="ARF79257"/>
        <property type="gene ID" value="B6264_10310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35198">
        <property type="protein sequence ID" value="OEV35198"/>
        <property type="gene ID" value="HS99_0033280"/>
    </dbReference>
    <dbReference type="OMA" id="EIPAAWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12670" checksum="9A50390670C15424" modified="2017-01-18" version="1">MEYTLLIHGDERVWNGLSEAEQAELDAAHVRFGRALHEAGVTVRYGAGLRRSCSARLVVPGGGSEAPVSDGPYREGHEHLGGLWVIDVADEAEAVSWARWMPAAPGDLVEVRPVRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3M1</accession>
    <name>A0A1E7N3M1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0032995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282771.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5292"/>
    <dbReference type="EnsemblBacteria" id="ARF80706">
        <property type="protein sequence ID" value="ARF80706"/>
        <property type="gene ID" value="B6264_18935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35280">
        <property type="protein sequence ID" value="OEV35280"/>
        <property type="gene ID" value="HS99_0032995"/>
    </dbReference>
    <dbReference type="OMA" id="SIYWWGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="206" mass="22678" checksum="1198F177CEC920F9" modified="2017-01-18" version="1">MSVVATATATETGHAHGSVNRPNMVSVGTIVWLSSELMFFAALFAMYFTLRSVKGAEFWAEKAHALNVTFSSVNTTILVLSSLTCQLGVFAAERGDVKKLRGWFILTFFMGAIFIGGQVYEYTELVKNDGLSLSSDPYGTVFYLTTGFHGLHVTGGLIAFLLVLGRTYAAKRFTHEQATAAIVVSYYWHFVDVVWIGLFATIYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R6</accession>
    <name>A0A1E7N3R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278736.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2441"/>
    <dbReference type="EnsemblBacteria" id="OEV35341">
        <property type="protein sequence ID" value="OEV35341"/>
        <property type="gene ID" value="HS99_0032490"/>
    </dbReference>
    <dbReference type="OMA" id="EPRHLWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="480" mass="52569" checksum="4DB691025A8BFEBC" modified="2017-01-18" version="1">MTAAGPADTAARLTGLVRALRGHGLRIGPAETVDAAAVLDVLGFADREQMRAGLAAALLRSDGQRKVFDAVFDLFFPLGVGTPEALRVEPPPAPDDPEPPRFGRPDPLRDQLRERLAAALAADDRAAQARLAGEVVEAFGRYGTGSTPGSDGWSAHQALGRLSPETLLARILAALREDPGREGPAREDLSERVLADEIRRRIQDFRAQVTGEARRRVAELRGPERIAERAVAPSTDRIDFLYAGREQLAELRRTVHPLARKLATRLAARRRRAARGQIDLRRTLRRSLTTGGVPLRPAYRLRRPGRPELVLLCDVSGSVAGFADFTMLLVQAMGEQFSKVRVFAFVNRTAEVTDLLRRGQDDPARLAARILAEARVMGHHGNSDYGSALGEFADRHPDAVGPRTCVLVLGDARNNHRDPNLDALRRISARARRVFWLNPEQPALWSTGDSAAPAYADVVEMHSCRNARRLGELIARLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N435</accession>
    <name>A0A1E7N435_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385704.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3888"/>
    <dbReference type="EnsemblBacteria" id="OEV35459">
        <property type="protein sequence ID" value="OEV35459"/>
        <property type="gene ID" value="HS99_0032390"/>
    </dbReference>
    <dbReference type="OMA" id="ATRLHWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="45360" checksum="AEB18454ED60AE41" modified="2017-01-18" version="1">MRRTRQPARTRQTPVRVGLFGLLGSGNLGNDGSLEAVLGYLRAEHPEAAVDALCGGPEVVAARYRIPATRLNWYRGEYRTASRAGAIAAKGLGKLVDPVRTAAWVRRHDVVIVPGMGVLEATLPLRPWGFPYALFLLCASGRLFGTRVALVGVGAAAIADRPTRALVRWSARLAAYRSYRDALSRDAVRAMGVDTARDAVHPDLAFALPTPPGTASPGPPGSPGPVCVGVMDFHGGNDDRARAERIHRRYLDGTTRFVRALVEDGRPVRLLTGDGVDARVVAAILDAVDSPLASAVEATSLADLTAETAAADTVVATRYHNLVCALKAGTPTLALSYAAKSDALMERMGLGAYCHPAREVDPDRLLEQFRELEKRSAELRQTLEERNRTASRQLEQQFTALTTALFPRTDTSRADTPRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N472</accession>
    <name>A0A1E7N472_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0031770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278155.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5540"/>
    <dbReference type="EnsemblBacteria" id="ARF79374">
        <property type="protein sequence ID" value="ARF79374"/>
        <property type="gene ID" value="B6264_10965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35486">
        <property type="protein sequence ID" value="OEV35486"/>
        <property type="gene ID" value="HS99_0031770"/>
    </dbReference>
    <dbReference type="OMA" id="IHNIGYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="31620" checksum="332B56FB06761571" modified="2017-01-18" version="1">MTQPPDARAADTGVIHDIGYRGYTGPRLGRAHATRSLFVQSLRAAYGLGRSGRSKVLPMLLLGVVTVPAVIYVAVAVYMKRDELPVEYAGYLSDLGLVVSIFLASQAPVLLSRDLRHHTVPLYFSRPITRADYVRAKFAAMACAQLLLMAVPLLVLYTGALLAGMDFGHNTGQFLDGLAAAVLYALVPTSVALVIAAATPRRGFGVAAIMGYLVVSSTVAAVVVDMRGPSPGGSDAAQWTALISPNGLVESLVNEVFDLGSGFDRRHAPGAFGAAVFALVAVAMVAGSYRLLLRRYSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4N2</accession>
    <name>A0A1E7N4N2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene930"/>
    <dbReference type="EnsemblBacteria" id="ARF80842">
        <property type="protein sequence ID" value="ARF80842"/>
        <property type="gene ID" value="B6264_19750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35649">
        <property type="protein sequence ID" value="OEV35649"/>
        <property type="gene ID" value="HS99_0006980"/>
    </dbReference>
    <dbReference type="OMA" id="AQNIFPN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="26855" checksum="F8CA97926CB5A09B" modified="2017-01-18" version="1">MLTNTLSRPLTGRVAVVTGASSGIGEASAEKLASLGARVVVLARRAERLAELVGRIEENGGAASAIAVDVTEAAAVQAAAERVEAEFGGADLLLNNAGVMLPAPIEELATGQWKQQIDLNITGLMNAIGAFTPQLVKAAAERGVADLINTSSIAAQNIFPNFAVYSGTKAYVSHLSRHLRAELGAKKVRVSAVEPGIVGTELQSHVTDQGALEWLEGSKETVEWLTPEDVAEMVGVIATLPARVNLQQVTIMPTGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Q5</accession>
    <name>A0A1E7N4Q5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281838.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene946"/>
    <dbReference type="EnsemblBacteria" id="ARF80828">
        <property type="protein sequence ID" value="ARF80828"/>
        <property type="gene ID" value="B6264_19670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35634">
        <property type="protein sequence ID" value="OEV35634"/>
        <property type="gene ID" value="HS99_0006900"/>
    </dbReference>
    <dbReference type="OMA" id="WQQFART"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="54483" checksum="2465AAB3CDCBF83B" modified="2017-01-18" version="1">MTSPTDSSLSTTPQVAVNDIGDADAFLAAIDETIKYFNDGDIVEGVIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPHEVVAVGDNIEALVLQKEDKEGRLILSKKRAQYERAWGTIEKIKEEDGIVTGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGKELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQTFLTTLQKGQVRSGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMDRERVSLSLKATQEDPWQQFARTHQIGQVVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVGDEIFVKVIDIDLERRRISLSLKQANEALGANPAEVEFDPTLYGMAASYDDQGNYIYPEGFDPEANDWLPGFEKQREEWERQYAEAQSRFEQHQAQVIKSREADAEAAAEGGDAVAAAAGGSYSSSSDEGSGALASDEALAALREKLAGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V0</accession>
    <name>A0A1E7N4V0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281632.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene852"/>
    <dbReference type="EnsemblBacteria" id="OEV35710">
        <property type="protein sequence ID" value="OEV35710"/>
        <property type="gene ID" value="HS99_0007375"/>
    </dbReference>
    <dbReference type="OMA" id="WTREIPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="40291" checksum="562A61C5D917E438" modified="2017-01-18" version="1">MLSLTGLPLQIIASAFAIVVFAATMWLWPKFSGKGWKSWLGRIGAFLATQLSVLAAMGLIANSYFGFYSSWTDLLGTSGGLGTVVDHQPNASGVSVTGEQKFYSAQGSEPDRSGLIQKVDVKGAGSGLSTEAYVYLPPQYFQPGFAKQRFPMAVVLTGYPGTPEKLISLMQYPASTLDAIEQKKLPPTILVMTRPTLVGDRDTECVDVPNGPQVETFFTSDLPKALATTYRIGTDPANRAVIGNSTGGYCALKFALRKPDSYPAAVALSGYYSAAHDPTTGDLFGGNDKLKQENDLLWRLKNQPAAPVSLLLTTAYDENNYDETKAMVAAFKAPTKMSTITLDTAGHNFHTWTREIPPALEWLGKHLTMPAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N555</accession>
    <name>A0A1E7N555_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550967.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene724"/>
    <dbReference type="EnsemblBacteria" id="ARF81018">
        <property type="protein sequence ID" value="ARF81018"/>
        <property type="gene ID" value="B6264_20800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35808">
        <property type="protein sequence ID" value="OEV35808"/>
        <property type="gene ID" value="HS99_0008025"/>
    </dbReference>
    <dbReference type="OMA" id="LTRICMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="21442" checksum="63EA28C9EC21E754" modified="2017-01-18" version="1">MTAISDRPQMLPEEFEQFARHLATTAEGVRPEFINGKLGVKPVPDGDHGRIIQWLLRICIQARPELYLHDQGLKVQGCRGGFARPDGTLADADAFVGHGDWAAPDRVLMVAEVTSFDSGTDRRDRVEKPRAYAETGIPVHLLIDRDSAEVLVRSRPDGVRSETVQTLPFGKTVRLPEPVGISLDTEPLKNWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5I6</accession>
    <name>A0A1E7N5I6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpA</name>
        <name evidence="9" type="ORF">HS99_0006730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281912.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene979"/>
    <dbReference type="EnsemblBacteria" id="ARF82934">
        <property type="protein sequence ID" value="ARF82934"/>
        <property type="gene ID" value="B6264_19500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35938">
        <property type="protein sequence ID" value="OEV35938"/>
        <property type="gene ID" value="HS99_0006730"/>
    </dbReference>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="27726" checksum="D26D702BF571C78F" modified="2017-01-18" version="1">MASKPSASKLSGVLAGAKADGRAALIGYLPAGFPTVEGGIRAVDALIEGGCDVVEIGLPHSDPVLDGAVIQTADDIALRGGVRIKDVLRTVQEVAAAHPGTAVLVMTYWNPVDRYGVARFAADLAAAGGAGCILPDLPVEESEEWRKAADAHGLDTVFVVAPSSKDARLAEVTAAGSGFVYAAAVMGVTGTRSAVGSLAEDLVARTRATTDLPVCVGLGVSNAEQAAEVARFADGVIVGSAFVKRILEAGEDEAAALDGVRALAGELAAGVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Z8</accession>
    <name>A0A1E7N5Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280941.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000273.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4950"/>
    <dbReference type="EnsemblBacteria" id="ARF80017">
        <property type="protein sequence ID" value="ARF80017"/>
        <property type="gene ID" value="B6264_14845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36074">
        <property type="protein sequence ID" value="OEV36074"/>
        <property type="gene ID" value="HS99_0030870"/>
    </dbReference>
    <dbReference type="OMA" id="SWVIWIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="9454" checksum="715AF72BC43A18F4" modified="2017-01-18" version="1">MKLSRRTSWFLTAFGVWSIMIWTTFVKNLWKDSGGQAFVNGDHSQPTAFFWIHLLLAITSFVLGIAVGTVGLRGLRAARRGPATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N674</accession>
    <name>A0A1E7N674_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0030660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284275.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8068"/>
    <dbReference type="EnsemblBacteria" id="ARF79819">
        <property type="protein sequence ID" value="ARF79819"/>
        <property type="gene ID" value="B6264_13715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36206">
        <property type="protein sequence ID" value="OEV36206"/>
        <property type="gene ID" value="HS99_0030660"/>
    </dbReference>
    <dbReference type="OMA" id="SAWACYC"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PMT_2" evidence="11">
        <location>
            <begin position="129"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV36206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="45992" checksum="DC47C459DC1ABECE" modified="2017-01-18" version="1">MSTASSTESSSTEPSATEPAPSAERPEERTGRVPGRFGVLVDRFAPALGAYAVVKAIGLTVFLVLLEHTGDYLKKQVGRGGGAHAWDVLGTWDGIWYQRIAENGYDPQLIPLHGFPLATYYENSAAFFPLYPWLMRLVGVVTGLGPYGSGIVVSVLASLVAAAGIFAIAERLAGFRAGVIAAVIWGLFPGSGVEWAVYSDSLFVALSAWACYCVMTRRWIAAGLLALVAGLNRPTAAALIAAVSIAALVALVRRTDGVARPLTAMLITPWGLIGYVAWVGWRMGDWGGYFKLQRGAWNRYFDFGASTLRTVMDVITGHWDFWQSNPVPDLIAIALLIALPGLLVLLRQARPPLVLWVYTGMTVFTALSSNQIFGNISRYLLPAFPLFIGLAVALRRVRTSSLVGMFAMPVIAAGWYAGYALFELGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N684</accession>
    <name>A0A1E7N684_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284288.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000732.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79814">
        <property type="protein sequence ID" value="ARF79814"/>
        <property type="gene ID" value="B6264_13680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36201">
        <property type="protein sequence ID" value="OEV36201"/>
        <property type="gene ID" value="HS99_0030625"/>
    </dbReference>
    <dbReference type="OMA" id="TGEMLNQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="23591" checksum="144B59EF2B3C9D82" modified="2017-01-18" version="1">MKFSKRAGAMLLAVGAGVLASQGAASAASVSPDQVGALEDRLSTQQVPADVPLGPLGGHLTAGIPTSLVMPPVPGRTTDNGLVPNHLVPQLPTGKLGPSARAQLPLPLVDRGADLGEVLLEAPAAPLQAKTPGLDVGKPPALVQDGTGQLADGRLRVDEVDPRLVPAAVQAVPGATASLGADQERISATEAVNHLADATTGTATGVLQQTSATDAATGTAAGLVQQGSGLAPLAGLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6B6</accession>
    <name>A0A1E7N6B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284250.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8054"/>
    <dbReference type="EnsemblBacteria" id="ARF79831">
        <property type="protein sequence ID" value="ARF79831"/>
        <property type="gene ID" value="B6264_13785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36219">
        <property type="protein sequence ID" value="OEV36219"/>
        <property type="gene ID" value="HS99_0030730"/>
    </dbReference>
    <dbReference type="OMA" id="APHSWQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="69" mass="7392" checksum="4AB5EF17E34710AB" modified="2017-01-18" version="1">MTASAEPLVRIVRGSLSDEELAALTAVLAARAAVAQQAAATAQVEPIANWQRLERRPAYYSPVSWQQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G6</accession>
    <name>A0A1E7N6G6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2638"/>
    <dbReference type="EnsemblBacteria" id="OEV36282">
        <property type="protein sequence ID" value="OEV36282"/>
        <property type="gene ID" value="HS99_0030200"/>
    </dbReference>
    <dbReference type="OMA" id="IHQPGVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="43460" checksum="ABE35D6D4C911601" modified="2017-01-18" version="1">MTGGWDAVVVGARVAGAATALLLARRGHRVLLIDRAAFPSDTMSTLYIHQPGVAKLSEWGLLPALLDSGCPVLDTIGYDVGGVRLAGPAPVMPGAPAALAPRRLVLDRLLVEAAVKAGVEFVDRANLQELVHSEGRVTGVRFRTASGVRTEHARLVVGADGMRSRVAQLVEAPVELSDPRASCVYYTGWVGISTGFGFHESPGNWIVRIPTHDDVTLISTYFPQDRFAEIKQDPFRHHLAAVRGTAPELYEQLAGAEQVEQIIGTGDQQNYFRRGHGPGWVLVGDAGHHLDTISARGITNALLQASFLAEELAGRVDDPAASARFTRRRDEELTEPYRSTLELARLTVTPSRLRMLREIAGSPELTRRYFAVVAGMLGIDELFDEDELLGDDDGLDGDDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q6</accession>
    <name>A0A1E7N6Q6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280544.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7739"/>
    <dbReference type="EnsemblBacteria" id="ARF82323">
        <property type="protein sequence ID" value="ARF82323"/>
        <property type="gene ID" value="B6264_28695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36386">
        <property type="protein sequence ID" value="OEV36386"/>
        <property type="gene ID" value="HS99_0029970"/>
    </dbReference>
    <dbReference type="OMA" id="FVGWADR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="28713" checksum="2DB5ECCB173CAD1B" modified="2017-01-18" version="1">MPNLQETLDLSSYVALGDSFTEGLNDPGADGAFAGWADRLAGMLAEGRPPGGFRYANLAVRGRLLDQIVAEQVPQVRRLQPDLVTFCAGGNDILRPGSDPDEVAERFETAIAQLAENAGTVLICTGFDTREVPLLKHLRGKIATYNGHMRAVADRYDCKVADLWSLRAVQDRRAWSEDRLHLSPEGHQRVALLAARSLGLRTAEDPEAAWPTARVLTAADQRRENLQWAREHLIPWVGRRLRGESSGDHVEAKRPELLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N750</accession>
    <name>A0A1E7N750_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289033.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79199">
        <property type="protein sequence ID" value="ARF79199"/>
        <property type="gene ID" value="B6264_09950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36499">
        <property type="protein sequence ID" value="OEV36499"/>
        <property type="gene ID" value="HS99_0028630"/>
    </dbReference>
    <dbReference type="OMA" id="EHLTECI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13475" checksum="9F5B39502837A205" modified="2017-01-18" version="1">MTTTQARTEPDHASGTDPHAGTPTTAAAHGNGHGPHGYSAQKDAHLKRLRRIEGQIRGLQRMVDEDVYCIDVLTQVSASTKALQSFALSLLEEHLRHCVAAAAEQGGVELDAKVAEASAAIGRLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N762</accession>
    <name>A0A1E7N762_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36536">
        <property type="protein sequence ID" value="OEV36536"/>
        <property type="gene ID" value="HS99_0028860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="22153" checksum="761BB132D77A2950" modified="2017-01-18" version="1">MGCTGVRRAGAPAAPAGETSAVGACAGVGTEGATGAGTATDLGAGTTDGTGTAVAAGAAVTIRDSPAGARSATSAPAVRSRSASCSAARRSSSRSTDAARTNAAGLAGYLGRLAASARWAASASLSACSATATARSRSSRAISVSALASRDFSAVSRRPNRVARSSATSAAYSASASCSSNRSSARIRCAADTSAAARAALSRWRSSTAKPRVAISAAMPTERTRMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E1</accession>
    <name>A0A1E7N7E1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289706.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7925"/>
    <dbReference type="EnsemblBacteria" id="ARF79109">
        <property type="protein sequence ID" value="ARF79109"/>
        <property type="gene ID" value="B6264_09435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36589">
        <property type="protein sequence ID" value="OEV36589"/>
        <property type="gene ID" value="HS99_0029150"/>
    </dbReference>
    <dbReference type="OMA" id="VAGHTIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="18440" checksum="BE9F4FB258DBB1AD" modified="2017-01-18" version="1">MSLNTRVIAALGAVVVVGAATVGTSVAIAAGQTEHNSHRATLTVGTSSMTADPLCWNDGSPLTDDQQDQCKANATKALKDGSLPSSDVVPSDRIGVGVSPNVAKTGWWASTNGGSSSQGGQTSLFSYAQGPTFSGLQTAGSVLNASGRTLVTVVEIDKKAEAPIAVWYFQLNGKNATDAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H3</accession>
    <name>A0A1E7N7H3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280653.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7795"/>
    <dbReference type="EnsemblBacteria" id="ARF82274">
        <property type="protein sequence ID" value="ARF82274"/>
        <property type="gene ID" value="B6264_28415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36423">
        <property type="protein sequence ID" value="OEV36423"/>
        <property type="gene ID" value="HS99_0029200"/>
    </dbReference>
    <dbReference type="OMA" id="IHHYMGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="361" mass="37737" checksum="8565EDB2F457B8DF" modified="2017-01-18" version="1">MAQQVKAVIARAKGAPVEVTTIVVPDPGPGEAVVRIQACGVCHTDLHYREGGINDEFPFLLGHEAAGIVESVGEGVTEVEPGDFVVLNWRAVCGQCRACKRGRPQYCFNTHNAKQKMTLLDGTELSPALGIGAFAEKTLVAAGQCTKVDPAAEPAVAGLLGCGVMAGLGAAINTGSVGRGDTVAVIGCGGVGGAAVMGSRLAGASKIIAVDIDDRKLETARKLGATHTVNSRTTDPVEAIRELTGGNGADVVVEAVGRPETYKQAFYARDLAGTVVLVGVPTPEMTLELPLLDVFGRGGALKSSWYGDCLPTRDFPMLIDLYLQGRLDLGAFVTETIELDAVEQAFERMHHGDVLRSVVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7P4</accession>
    <name>A0A1E7N7P4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7777"/>
    <dbReference type="EnsemblBacteria" id="OEV36710">
        <property type="protein sequence ID" value="OEV36710"/>
        <property type="gene ID" value="HS99_0028005"/>
    </dbReference>
    <dbReference type="OMA" id="MAVRTWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="11906" checksum="D4E23218054603B8" modified="2017-01-18" version="1">MAVRTWYTDTRAAVCTLAGDLDIETLEPARSALDGLVEQHPPLLVVDLAGVDFCDSSGLNLLLQTRMAAVSADVEFRLAAPSVTVQRLLELTCADTVFSLHPTVGAALAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T1</accession>
    <name>A0A1E7N7T1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4793"/>
    <dbReference type="EnsemblBacteria" id="OEV36762">
        <property type="protein sequence ID" value="OEV36762"/>
        <property type="gene ID" value="HS99_0027510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24078" checksum="3071C25069CCBD7B" modified="2017-01-18" version="1">MSAGPGLPGALAHLEPLLDRGGYAALTLLVGLDNVLVPVPGQTVLIVAAVYAGSGRMNVVLVALVAWAAATAGAEGAYVLGRHQGSALIERYGRYVGLTTRRYERAEDFYRRRGLPIVFAARFVDVLRQTNGLLAGANRLPHTRFCVANAVGAAVWTAVWAGLGYGAGTDIGPLYHQAVRYQLLLLPVAALLVLGLGVHALWRRRRRRADDDPATSRRPEHRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8B5</accession>
    <name>A0A1E7N8B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388642.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6818"/>
    <dbReference type="EnsemblBacteria" id="ARF78613">
        <property type="protein sequence ID" value="ARF78613"/>
        <property type="gene ID" value="B6264_06530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36940">
        <property type="protein sequence ID" value="OEV36940"/>
        <property type="gene ID" value="HS99_0027165"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112286" checksum="F9378C3B201E6914" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F7</accession>
    <name>A0A1E7N8F7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">HS99_0027215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030057414.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6808"/>
    <dbReference type="EnsemblBacteria" id="ARF78603">
        <property type="protein sequence ID" value="ARF78603"/>
        <property type="gene ID" value="B6264_06480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36948">
        <property type="protein sequence ID" value="OEV36948"/>
        <property type="gene ID" value="HS99_0027215"/>
    </dbReference>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="98" mass="10711" checksum="C297DBE22F8053E2" modified="2017-01-18" version="1">MPGITREEVAHLARLSRLELKPEELDHFAEQLDVIIGAVARVSEVAGQDVPPTSHPLPLTNVMRADEVRPSLTPEQALSGAPAAEEQRFRVPQILGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H5</accession>
    <name>A0A1E7N8H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stilbene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557872.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5983"/>
    <dbReference type="EnsemblBacteria" id="ARF81725">
        <property type="protein sequence ID" value="ARF81725"/>
        <property type="gene ID" value="B6264_25030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37000">
        <property type="protein sequence ID" value="OEV37000"/>
        <property type="gene ID" value="HS99_0003985"/>
    </dbReference>
    <dbReference type="OMA" id="PIWGLGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="39020" checksum="4227C7911759FF46" modified="2017-01-18" version="1">MTNTTTTDLARIVAVSTAVPETSYSQAELLDIFRIEDSRVRSVFLNSAIDRRHLTLPPEGPDGTRVPEVQGQLLAKHKTHAVDMGVRAVQDLLKRTGADLSDIGYLCCVTTTGFLTPGLSALIIRELGIDPHTSRLDVVGMGCNAGLNALNAVNGWSRANPGRLAVMVCAEACSAAYVFDGTMRTSVVNSLFGDGAAAVALMAGEPELPLTQVEGPRILKFASYIITDAVDAMRYDWDDTQDRFSFYLDPQVPYVVGAHAERVVDRLLTGTGLRRSDIRQWLVHSGGKKVIDAVGVNLGLTRHDVRHTTGVLRDYGNLSSGSFLFSYERLLQEQVVEPGDHCVLMTMGPGSTIETALVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N932</accession>
    <name>A0A1E7N932_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556552.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N932"/>
    <dbReference type="EnsemblBacteria" id="OEV37206">
        <property type="protein sequence ID" value="OEV37206"/>
        <property type="gene ID" value="HS99_0005190"/>
    </dbReference>
    <dbReference type="OMA" id="EGQIRSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="275" mass="30475" checksum="AA2F6A958C58406E" modified="2017-01-18" version="1">MPICTTRDGVEIFYKDWGQGRPVVFIHGWPLNGDAWQDQLKAVVDAGYRGIAHDRRGHGHSTPVWDGYDFDTFADDLNDLLTDLDLRDVTLVAHSMGGGELARYVGRHGTGRLRSAVLLSAIPPVMIKSDKNPDGVPDEVFDALKNGVLTERSQFWKDTAEGFFSANRPGNKVTQGNKDAFWYMAMAQTIEGGVRCVDAFGYTDFTEDLKKFDIPTLVVHGDDDQVVPIDATGRKSAQIIPNAELKVYEGSSHGIAMVPGDKEKFNRDLLEFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P2</accession>
    <name>A0A1E7N9P2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556430.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5423"/>
    <dbReference type="EnsemblBacteria" id="ARF82478">
        <property type="protein sequence ID" value="ARF82478"/>
        <property type="gene ID" value="B6264_29640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37364">
        <property type="protein sequence ID" value="OEV37364"/>
        <property type="gene ID" value="HS99_0006165"/>
    </dbReference>
    <dbReference type="OMA" id="GAEMSIV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="23091" checksum="9093508BD10CE9BF" modified="2017-01-18" version="1">MPISPNQGSTGGGTTVTITGTNLSGATAVHFGSKLGTITANTATSVTVISPSGNGTVPVTVTTPGGTSNPLSFYYIGAPFKAGISPTSGVTAGGNTVTITGTGLSTATAVHFGSASATPTVVSDGQLTVTVPAGTAAGSVGVSVTTAGGTNNGLSYTYVDGPTIGTPVPAAGPTSGGTAVTIPGSGFTTTQSVTFGGAPAPFDVVSDTEIAAVTPPGTAGAADIVVTTTGGSATGTGAFTYVAGPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA00</accession>
    <name>A0A1E7NA00_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287184.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000571.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7989"/>
    <dbReference type="EnsemblBacteria" id="ARF79056">
        <property type="protein sequence ID" value="ARF79056"/>
        <property type="gene ID" value="B6264_09125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37516">
        <property type="protein sequence ID" value="OEV37516"/>
        <property type="gene ID" value="HS99_0026230"/>
    </dbReference>
    <dbReference type="OMA" id="DGQKVQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7132" checksum="E0D047F1EDD8CA6C" modified="2017-01-18" version="1">MAQGTVKWFNAEKGFGFIAQEGGGPDVFVHYSAINANGFRSLEENQAVTFDVTQGPKGPQAENVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA39</accession>
    <name>A0A1E7NA39_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552357.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1139"/>
    <dbReference type="EnsemblBacteria" id="ARF79019">
        <property type="protein sequence ID" value="ARF79019"/>
        <property type="gene ID" value="B6264_08895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37552">
        <property type="protein sequence ID" value="OEV37552"/>
        <property type="gene ID" value="HS99_0026460"/>
    </dbReference>
    <dbReference type="OMA" id="GWYWENY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="28938" checksum="62DE75464A4B9B40" modified="2017-01-18" version="1">MYVVTGATGQLGRLVVEGLLARVPASEVAVAVRSAGKATDLAARGVDVRVVDYDEPRTLAGAFAAGDRVLLISGSEVGRRVPQHRAVVEAARTAGVALLAYTSILGTATFRLAEEHKATEELILASGLPYAFLRNGWYTENYLADAAGTVARGVVPGSAGDGRVATAPRRDYADAAVAVLLDGSEQNRAYELSGDAAWSLPELAAELAKASGEPVGHRDVTPAEHLDVLVGAGLPQGFAEALVDVDAGIARGELAGTPGDLARLIGRPTVPLAESVRAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAA9</accession>
    <name>A0A1E7NAA9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="8" type="ORF">HS99_0025355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290437.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6239"/>
    <dbReference type="EnsemblBacteria" id="ARF79891">
        <property type="protein sequence ID" value="ARF79891"/>
        <property type="gene ID" value="B6264_14140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37635">
        <property type="protein sequence ID" value="OEV37635"/>
        <property type="gene ID" value="HS99_0025355"/>
    </dbReference>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="19529" checksum="91349B88F05E2BD1" modified="2017-01-18" version="1">MARPDKAAAVAEITDKFRGSSAALLTEYRGLSVKQVKTLRRSLGDNAEYAVVKNTLTKIAANEAGISELDDLFNGPTAVAFVTGDPVESAKALRDFAKENPALIIKGGVLDGKALSADEIKKLADLESREVLLAKLAGALKAKQSQAAALFQALPSKLVRTVDALRDKVEQGGAGTPAPAAEDEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAI4</accession>
    <name>A0A1E7NAI4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">HS99_0025670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280806.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1660"/>
    <dbReference type="EnsemblBacteria" id="ARF79949">
        <property type="protein sequence ID" value="ARF79949"/>
        <property type="gene ID" value="B6264_14460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37692">
        <property type="protein sequence ID" value="OEV37692"/>
        <property type="gene ID" value="HS99_0025670"/>
    </dbReference>
    <dbReference type="OMA" id="GFRDFMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV37692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14974" checksum="8A7456BD02F8C4AA" modified="2017-01-18" version="1">MLKGFRDFMMRGNVVDMAVGVVIGAAFTGVVTGFVSAFLTPLVGVVVGAAGDFSSYKATVAGVTFPYGQFLNVVIAFVMTAAVLYFCVVLPVTKATERYLPKKPKTPKRPCPECLTEIPQAARRCSACTAHVEPLTVTTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAK4</accession>
    <name>A0A1E7NAK4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="7" type="ORF">HS99_0025785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1637"/>
    <dbReference type="EnsemblBacteria" id="ARF79970">
        <property type="protein sequence ID" value="ARF79970"/>
        <property type="gene ID" value="B6264_14575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37712">
        <property type="protein sequence ID" value="OEV37712"/>
        <property type="gene ID" value="HS99_0025785"/>
    </dbReference>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="37552" checksum="D9779C135224E826" modified="2017-01-18" version="1">MADEPLVLGIETSCDETGVGIVRGTTLLADAVASSVNDHARFGGVVPEIASRAHLEAMVPTIQRALDTAGVKAGDLDGIAVTAGPGLAGALLVGVSAAKAYAWALDKPLYGVNHLASHICVDQLEHGRLPSPTMALLVSGGHSSLLLSEDITTDVRPLGATIDDAAGEAFDKVARVLGLGFPGGPIVDRTAREGDPEAISFPRGLSGRNDPAYDFSFSGLKTAVARWVEAKRRAGEEVPIADVAASFQEAVTDVLTRKAVKACRDNGVDHLMIGGGVAANSRLREMAQQRCDRAGIRLRVPRPGLCTDNGAMVAALGSEMVWRGRTPSAFDLSADSSLPVTDVHVPHTDFHGQAYDALGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR0</accession>
    <name>A0A1E7NAR0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3443"/>
    <dbReference type="EnsemblBacteria" id="ARF78109">
        <property type="protein sequence ID" value="ARF78109"/>
        <property type="gene ID" value="B6264_03525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37758">
        <property type="protein sequence ID" value="OEV37758"/>
        <property type="gene ID" value="HS99_0024485"/>
    </dbReference>
    <dbReference type="OMA" id="DVWFAIL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="PTHR31252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="41910" checksum="1B0A5621B4253ED7" modified="2017-01-18" version="1">MIIELPLEGTGHGSAGEPVDLGNERFLRAVVGGEFLVRHRSVTAMVERPRPVLTEVPGREPAEPEPTCSLLLRAAHVAFADHLPLSLSPDVLWYAVVHEVAVHVRMYPPRYRALFGAANGARVLSVRDDTLIGRDADWARSLRLVREPLTAALGADVVRLFRPEFSTTTPDDEASALVALMDVVSPYYDFRWETRCGIPKVRLEGTAEDWALLSARAGELAERFDWLAPWFAELRPVLAQIAATAAGGPVDEAFWRSLYKWQSVSGGPRVTGWLTAFFAHTQTPDGPRLRQTFGWREAAEWPYHRDAFAVNDFPSHLSTVPFVWECLGVERPMAFVGGVLGIERDGEFLRPRLGHAVLERASGAGGQWTDGPGVMSAGGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAT8</accession>
    <name>A0A1E7NAT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388194.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7940"/>
    <dbReference type="EnsemblBacteria" id="ARF82722">
        <property type="protein sequence ID" value="ARF82722"/>
        <property type="gene ID" value="B6264_09355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37583">
        <property type="protein sequence ID" value="OEV37583"/>
        <property type="gene ID" value="HS99_0026000"/>
    </dbReference>
    <dbReference type="OMA" id="VDCYAGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16685" checksum="052EF2BE433E0C03" modified="2017-01-18" version="1">MAWLAAQGRTGQWGDQPFSTNPARVEHIEQYAAEPFLIRLAVDDEGRTVGCCVLAEEPGKYIPLVDERELYVRHLVTDRSRKGSGIGAALIADAVEEARRRGIGLLRVDCYAGADRKLVGQYRALGFTETVGFEVEQPTGTWPGQVLEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB27</accession>
    <name>A0A1E7NB27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278256.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2114"/>
    <dbReference type="EnsemblBacteria" id="ARF79456">
        <property type="protein sequence ID" value="ARF79456"/>
        <property type="gene ID" value="B6264_11500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37906">
        <property type="protein sequence ID" value="OEV37906"/>
        <property type="gene ID" value="HS99_0023830"/>
    </dbReference>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="356" mass="38139" checksum="EEC4C4B5F2A9F9BD" modified="2017-01-18" version="1">MSGRRGLGRGLGALIGPAAPADGGAAQPVTATPAPTPVVTTGTTSPASVPVLPGGRATVAARAAVGRRPEQPAPVPGASFAELPLDAITPNPRQPREVFDEDKLAELVASIKEVGLLQPIVVRQIEAGRYELIMGERRWRASREAGLERIPAIVRATEDDKLLLDALLENLHRAELNPLEEAAAYDQLLRDFSCTHEELADRIGRSRAHVSNTLRLMKLPASVQRRLAAGTLTAGHARALLPLTDPEAQEKLAARIIAEGLTVRSVEELVVLMRSEEPREAKRQTPKAGKIISPAFNDLASRLSDRFDTRVKVEVSQRGGKLGKGKVVLEFGSVEDLNRILDSMAPGEDGLRLSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB31</accession>
    <name>A0A1E7NB31_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278235.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2136"/>
    <dbReference type="EnsemblBacteria" id="ARF79439">
        <property type="protein sequence ID" value="ARF79439"/>
        <property type="gene ID" value="B6264_11370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37889">
        <property type="protein sequence ID" value="OEV37889"/>
        <property type="gene ID" value="HS99_0023705"/>
    </dbReference>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="23198" checksum="BFB3B03DFF6B970C" modified="2017-01-18" version="1">MTTQSTPPRILVVDNYDSFVFNLVQYLYQLGATCEVVRNDEVTVEHAVRRAGEEGFDGVLLSPGPGAPEEAGVCIAMVHHCAGIGLPVFGVCLGLQSIAVAYGAVVGRAPELLHGKTSPVEHEDGGVFEGLPSPLTATRYHSLAVDPATVPDELVVTARTASGVVMGLRHRELPVEGVQFHPESVLTEGGHRMLANWLAECGFPQAVDRSAGLAPVIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB43</accession>
    <name>A0A1E7NB43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278257.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2113"/>
    <dbReference type="EnsemblBacteria" id="ARF79457">
        <property type="protein sequence ID" value="ARF79457"/>
        <property type="gene ID" value="B6264_11505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37907">
        <property type="protein sequence ID" value="OEV37907"/>
        <property type="gene ID" value="HS99_0023835"/>
    </dbReference>
    <dbReference type="OMA" id="CVFWELD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="22332" checksum="540D758F9F8BA20E" modified="2017-01-18" version="1">MGRRIAPLTLDNLADLPTGCRSCVFWELDPVSAKEAVESGKPELEKEGWISAVLLEWGSCGRIVYVDDQPAGFVLYAPPAYVPRSQSFPTSPVSPDAVQLMVSRVLPGYQRQGLGRVLVQTVAKDLLGRGVRAIEAFGSAGRVSTSCVLPADHLLAVGFKTVRPHPRYPRLRLEARTTLSWRGDVEGALERLLGGGRKEPALRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBA4</accession>
    <name>A0A1E7NBA4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0024195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278348.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000673.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2041"/>
    <dbReference type="EnsemblBacteria" id="ARF79520">
        <property type="protein sequence ID" value="ARF79520"/>
        <property type="gene ID" value="B6264_11870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37965">
        <property type="protein sequence ID" value="OEV37965"/>
        <property type="gene ID" value="HS99_0024195"/>
    </dbReference>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="11">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV37965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="36402" checksum="C12E472492D6B34F" modified="2017-01-18" version="1">MPIATPEVYNEMLDRAKAGKFAYPAINVTSSQTLHAALRGFAEAESDGIIQISTGGAEFLGGQHNKDMVTGAVALAEFAHIVAAKYDITVALHTDHCPKDKLDGYVRPLLAISAERVAKGENPLFQSHMWDGSAETLADNLSIAQELLAQAAAAKIILEVEITPTGGEEDGVSHEINDELYTTVNDAVRTAEALGLGEKGRYLLAASFGNVHGVYKPGNVVLKPELLRELQDAIGKQYGKTDPFDFVFHGGSGSTAEEIATALENGVVKMNLDTDTQYAFTRPVAGHMFANYDGVLKVDGEVGKKNTYDPRTWGKLAEAGMAARVVEAAEQLRSAGKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBG4</accession>
    <name>A0A1E7NBG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366689.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79556">
        <property type="protein sequence ID" value="ARF79556"/>
        <property type="gene ID" value="B6264_12080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37998">
        <property type="protein sequence ID" value="OEV37998"/>
        <property type="gene ID" value="HS99_0024395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="471" mass="48690" checksum="1426BF5FBC479DC6" modified="2017-01-18" version="1">MTDKLPRPGGGDDDGLAGTPTERLLREAMNARTSLITAHDLRPAAPPRTRVRRLRPVYAVTVPLLGLAAAAAIGVVTLHGSPVAKQDVPPPPAASLTASPGPTPTPTPSTSASAAPTGDAQTADPLADVTPTSSRSATGAPTGPATPYTFRGVKLKVPAGWRVAPADPADLHLCVLSPGAPQGASAQNCQPYGVDLAVFDTGSPGWPSTADLDAQSGWSHQPNCPVWGDPHPPAAGESVSSTGPTKSAPTVSGRPALKSQWQVTCGQSPFTAQVWALPKDQVFVSAVGLRDEYQAGLQSIVNSLDVSGHSQAPQTTAPPGPSEVAVSIDGLPTGQQLRVGSAVVTFSVTFRNDGRSASGQLEPLVFTDRYAGTPVVPGQQLPNDGKLELQTDSGWITKPMSPAGDTSYATARDEELFSLAPGQSRTLIYRLTMGPRSGPGDMPLRAQAVLPYHGGDLTVIARQDLTVKLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP1</accession>
    <name>A0A1E7NBP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000626.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5949"/>
    <dbReference type="EnsemblBacteria" id="ARF79682">
        <property type="protein sequence ID" value="ARF79682"/>
        <property type="gene ID" value="B6264_12900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38111">
        <property type="protein sequence ID" value="OEV38111"/>
        <property type="gene ID" value="HS99_0023205"/>
    </dbReference>
    <dbReference type="OMA" id="RAPHHYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025115">
        <property type="entry name" value="DUF4034"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13226">
        <property type="entry name" value="DUF4034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="41813" checksum="167DDB500D5A4304" modified="2017-01-18" version="1">MAVLLLLIPPLIWALAKLATRYFNRRTADLQQKTEALKAASAARAQIDPTAFGLPSDGDLDPTRATAPGADAAQLAQAEEAATAGDWKPFAAYLAEAGTDWNERYRRLWKLAEHASKDDGWLSAWRAAEPGSADAAVVHATALIDLAWQVRSSKQAKHVTREQFDAFHRVLGEATEASRAAAELAPDDPSPFVSQLPIAMGLGWSHEQFDALWQQVIARAPYHYSAHQTALQYWCRKWSGSHEQMSAFAERAAAGAPPESLLSGLRLAALHELEFTEDDYRSWMTPQANQAIDKVIADLKTVPTDDPRLPGLHHLLAYGLTHNRRWAEAVEQFRLADRYIDHAPWTYTGRPKATYIEIRNRARTGWDKAGRPTPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC07</accession>
    <name>A0A1E7NC07_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5933"/>
    <dbReference type="EnsemblBacteria" id="ARF82799">
        <property type="protein sequence ID" value="ARF82799"/>
        <property type="gene ID" value="B6264_12810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38188">
        <property type="protein sequence ID" value="OEV38188"/>
        <property type="gene ID" value="HS99_0023285"/>
    </dbReference>
    <dbReference type="OMA" id="CTTRTGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9203" checksum="006520DB2BA6A665" modified="2017-01-18" version="1">MMIKAGTGQPLRQLLGGWRRRSRGAEGRLRRTVRRRGRSDAGMTTAEYAVGTLGACALAAGLYKVVTSTAITGALTEMLERALHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC9</accession>
    <name>A0A1E7NCC9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="1">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hpf</name>
        <name evidence="3" type="ORF">HS99_0022735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283945.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000530.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4125"/>
    <dbReference type="EnsemblBacteria" id="ARF80138">
        <property type="protein sequence ID" value="ARF80138"/>
        <property type="gene ID" value="B6264_15540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38337">
        <property type="protein sequence ID" value="OEV38337"/>
        <property type="gene ID" value="HS99_0022735"/>
    </dbReference>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25011" checksum="890514F2956C23E9" modified="2017-01-18" version="1">MDIVVKGRKTEVPKRFREHVAEKLEKVQKFDGKVISLDVEVSKEHNPRQADRSDRVEITLRSRGPVIRAEAAAADAYAALDLAAAKLDAQLRKSADRRRVHKGGANGRTPISVAEATAALAALPDTTAQEGETNGAVRKTMMGSLEVEGEGPLVVREKTHSAAPMALDQALYEMELVGHDFYLFVEKDSGLPSVVYRRHGYHYGVIHVQPDMAAGVASGAGGAIGRFDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD8</accession>
    <name>A0A1E7NCD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-CoA--3-ketoacid-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558062.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000697.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1759"/>
    <dbReference type="EnsemblBacteria" id="ARF82865">
        <property type="protein sequence ID" value="ARF82865"/>
        <property type="gene ID" value="B6264_16190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38347">
        <property type="protein sequence ID" value="OEV38347"/>
        <property type="gene ID" value="HS99_0022090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="21370" checksum="5F71923041AADABC" modified="2017-01-18" version="1">MAARAARELRDGQYVNLGIGLPTLIPNHLPPGVRVVLHSENGVLGVGPYPVEGAEHPDLINAGKETVTVTPGAAYFDSAFSFGMVRAGRIHVSVLGAMQVSATGDLANWMIPGRMVKGMGGAMDLVHGARRLIVVMEHTARDGSPKIARELSLPATGRQVVDRIVTDLAVVDVTPEGLRLVETAPGVSPAEVRAATDAPLLSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND24</accession>
    <name>A0A1E7ND24_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000654.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene660"/>
    <dbReference type="EnsemblBacteria" id="ARF77603">
        <property type="protein sequence ID" value="ARF77603"/>
        <property type="gene ID" value="B6264_00500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38577">
        <property type="protein sequence ID" value="OEV38577"/>
        <property type="gene ID" value="HS99_0020085"/>
    </dbReference>
    <dbReference type="OMA" id="GINRTIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="32519" checksum="C77445463C74582D" modified="2017-01-18" version="1">MVLGEIPTTRVSARLQQSPGHLIRVAQQVHTRLWSEHVGADLTAPQFAVLLVLALEPGADQRTVGERASLDKATMAEMVARLVRRGLVLRRRDPADGRRKLLALSQSGAQAVREATGGVVRVQRVLFEPLTPEEQVEIVRVMAKIARLEPAAVAVFSDARPILDAQRAIGYLIRVGQQVHTKLWSEHVGAELTAPQFAVLDALELEPGADQRTVGELASLDKATMAEMVSRLVRRGLVQRRRDPSDGRRNLLSLSPAGQDLLHRSAAGVAEVQRLLLAPLEEEEHEAALALIAKAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND43</accession>
    <name>A0A1E7ND43_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737799.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene611"/>
    <dbReference type="EnsemblBacteria" id="OEV38612">
        <property type="protein sequence ID" value="OEV38612"/>
        <property type="gene ID" value="HS99_0020335"/>
    </dbReference>
    <dbReference type="OMA" id="AWEAQEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1084"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1116" mass="119702" checksum="3E50B092AC9D599D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE0</accession>
    <name>A0A1E7NDE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0021685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3098"/>
    <dbReference type="EnsemblBacteria" id="OEV38503">
        <property type="protein sequence ID" value="OEV38503"/>
        <property type="gene ID" value="HS99_0021685"/>
    </dbReference>
    <dbReference type="OMA" id="WIDFALF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="470" mass="49492" checksum="4B2A2951D7CED9DD" modified="2017-01-18" version="1">MSTAHSQRASGEAHLGHVIFISAAAAMGGFLFGYDSAVINGAVTGIQKHFAVGNGTTAFVVAIALLGSAVGAVVAGRLADHLGRVRTMLLAATLFAASGVGSMFPPNIEALAAWRVVGGIAIGIASVIAPTYIAEVAPTAYRGRLASFQQMAIVLGITVSQLANWALNQAAGGESTGHLGGIQAWQWMLGVETIPALVYGLMALAIPESPRYLIADHREAQARKVLVEVEGEDVDLDARVAEIRAVLASTHKPRPKDLLGGRFGLLPIVWVGIGASVFQQFVGINVIFYYSSFLWQSVGINESNSLLISLSTSIINVIGTVIAMVLVDRIGRKPLALAGSTGMALALATAAWAFSYRRGTGATATLDNTHATVALIAAHVFVLCFAFSWGVVVWVLLGEMFPNRIRALALSVAASAQWIANWAITVSFPDLADWNLSATYVIYAAFALLSIPFVAFCIRETKGRALEEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDF7</accession>
    <name>A0A1E7NDF7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1812"/>
    <dbReference type="EnsemblBacteria" id="OEV38732">
        <property type="protein sequence ID" value="OEV38732"/>
        <property type="gene ID" value="HS99_0020790"/>
    </dbReference>
    <dbReference type="OMA" id="YFERRDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="178" mass="19579" checksum="EA7A4218DB536639" modified="2017-01-18" version="1">MKILVAGGFGAGKTTLVGSVSEIRPLRTEEELSELGRPVDDTSGVETKRTTTVAMDFGRIDLRPGLALYLFGTPGQDRFWFIWDELARGALGAVVLADTRRLADCFPSVDFFEQRGIPFLVAVNCFEGTERFAPEEVRDALDLDPGIPVVLCDARLREDGKELLVTLVEHAAALRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDQ4</accession>
    <name>A0A1E7NDQ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-ketoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281144.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000383.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene597"/>
    <dbReference type="EnsemblBacteria" id="ARF77654">
        <property type="protein sequence ID" value="ARF77654"/>
        <property type="gene ID" value="B6264_00820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38623">
        <property type="protein sequence ID" value="OEV38623"/>
        <property type="gene ID" value="HS99_0020405"/>
    </dbReference>
    <dbReference type="OMA" id="ISITQSC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="25981" checksum="981A88AA66AD1412" modified="2017-01-18" version="1">MARFAGKVAVVTGAAQGIGAATARRLAEEGATVAVVDLTAERAAGTVAEITAKGGTAKAYGCDVADYEAVDAVFARVVEELGGLHILVNNAGITRDNLFFKMPKADWDTVLTVNLTSAYNCSHVAQKYMVAQKYGKIVSLSSRSALGNRGQANYAAAKAGIQGLTATLAIELGPFNINVNAVAPGYIATAMTAATAERVGATAEDHQAEVAARTPLRRVGQPEEIASVVAFLASEEASYVSGQTLYVNGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR5</accession>
    <name>A0A1E7NDR5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556311.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5118"/>
    <dbReference type="EnsemblBacteria" id="OEV38837">
        <property type="protein sequence ID" value="OEV38837"/>
        <property type="gene ID" value="HS99_0019420"/>
    </dbReference>
    <dbReference type="OMA" id="PGWINGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="36836" checksum="807EA94031A5DAF1" modified="2017-01-18" version="1">MLRTTLATCPTPTVPDDQVALYAVDSAGAARTVTRHQLAEQVDRAAAVMRRLGVQAGDQVALHLPVIPEAAVALLACTRIGAVPTTLDTWPTPRPHPHPHPHPHPHPHPHPHPGDELARRRRRHVRLVVTADGGCHQGAPQDWLATVDQAFDRAGAATPTAPPILVVQYGSRPTQRRADHHRWWHRALAGAAIGTDLTGPTGGELAAGLRLGLHSTDVYWCAASLEWLVRHPTAVSGPLAVGAAQVLCEDGDWWARTGRLWETVHDRGVSVLHAGPDALRDVLSRSGTDGRQGQDALDLRRVAVIGGADESELWYWQRERSSATTATPWELRVGSSPWAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV9</accession>
    <name>A0A1E7NDV9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557893.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000266.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000080_gene6270"/>
    <dbReference type="EnsemblBacteria" id="ARF81223">
        <property type="protein sequence ID" value="ARF81223"/>
        <property type="gene ID" value="B6264_22050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38818">
        <property type="protein sequence ID" value="OEV38818"/>
        <property type="gene ID" value="HS99_0019315"/>
    </dbReference>
    <dbReference type="OMA" id="MFRNNVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="269" mass="28741" checksum="35A20D30ABFA9A8F" modified="2017-01-18" version="1">MAEIRVNGISLHYEARGEGPGVVLVHGSWSDADTWERVLPGLAESTTAVAYDRRGHSRSEDLLTQGSVHEDAADLAGLVQGLGLAPAFVYGDSYGALITLRLAAARPDLLRGIAVHEPPGSGILLTDPDLRPIGTAFADRIAAVRELLSQAESAAAAELYVDSLAFGPGAWEQLPAPVRHAYIRNAPTYLDELRDPDALDLDLAGLARFTEPALLTQSDDSAPMFGEVLDLIDLALPKAERHLYTGAGHAPHLSQPEEWVRVVLPRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX8</accession>
    <name>A0A1E7NDX8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5119"/>
    <dbReference type="EnsemblBacteria" id="ARF81241">
        <property type="protein sequence ID" value="ARF81241"/>
        <property type="gene ID" value="B6264_22160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38838">
        <property type="protein sequence ID" value="OEV38838"/>
        <property type="gene ID" value="HS99_0019425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="26039" checksum="3EC25474EB3E5233" modified="2017-01-18" version="1">MTATHRPLPRAAGIAAVLSLLPGALLVTGCTVDHGISAVPDPSSTLTAARVPSSPPGASKPADGRVPPGSLGDPADAPSDPPVFGTTGPRTASYSGLGTLSSCASGRRIAALNAPLSDVPDGTRVGATAATGANSEEWLVWAEPDGGLALQALLSSGAPVPQLITADRAGAVYLRADVTAGDDVTAGTVDVSAQRWQLTDRRPFPGSAATDSTTDGCLRIRTQDGGGCLLDNGSDVPLVVGDCSSRAAWWGAQGLSGHTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE48</accession>
    <name>A0A1E7NE48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38969">
        <property type="protein sequence ID" value="OEV38969"/>
        <property type="gene ID" value="HS99_0017825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="41355" checksum="FFB7852BF41A063B" modified="2017-01-18" version="1">MAESMLFGAPTCTVCGKEMEPSATGRPRKYCSKACSSKADRAREKEKREQVLTAAPENPRGETPPLADLPADGPAAELLELGEELRRHGERFLLQLERAEREGDGALARQALEEVLRAADGLTARHRELAERILSAHPTQTSTSGESGPEPIVSPRGETAALSDTPASTGVPASARPAATPRPAPATGGPGPADRPAPVAPRGETPSPTDPVPARPQASSAPVPPRGETRPVAQPATAAPVAPRGETLPDGERLRGLVDQRLAQQQTAPRPTPAQPTPATPQQPTEVPVPADPMHRRLPPSDVRVALDAGRFGDWWALAGWTVNPDVYLVTGEGHQIGWVERGLTGIGDRWVAVYEGYFIGDVHTQEAMLHDTPEQAAFTVHTAYLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE53</accession>
    <name>A0A1E7NE53_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0019455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5125"/>
    <dbReference type="EnsemblBacteria" id="OEV38925">
        <property type="protein sequence ID" value="OEV38925"/>
        <property type="gene ID" value="HS99_0019455"/>
    </dbReference>
    <dbReference type="OMA" id="PEAFYTC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199040" description="Chitin-binding type-4 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="4">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="36162" checksum="9E08D4692A6611E9" modified="2017-01-18" version="1">MNSRRNRVLAVACGTLPLLLLGMAGKAQAHGSMQNPISRVYGCNLEGPEHPKSAACQAAVAASGTQAFYDWMGVRIGDAAGRHRELIPDGKLCSAGNDEYKGLDLPRADWAATSLPASGSFTFRYRGTAPHRGSFELYVTKDGYDPTKPLKWSDLEPTPFYKATDPSLVDGSYQMTAQLPKKQGRHLIYAIWQRSDSPEAFYSCSDVVFGGAGSSTAPGTASNPGTAPGAGTAPGKGSGQGAGSTAGAASGSGGTSGTGAGAGAAKPSAAGSNSDMDMSMDHGSTSSPAGGSAQSGDTSQADSQTGVAAGSTPTDSSTQLAHTGGSNIVPLTVGATAVLGAGGATLFLARRRRSHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF29</accession>
    <name>A0A1E7NF29_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284898.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3651"/>
    <dbReference type="EnsemblBacteria" id="OEV39310">
        <property type="protein sequence ID" value="OEV39310"/>
        <property type="gene ID" value="HS99_0000930"/>
    </dbReference>
    <dbReference type="OMA" id="PWALMEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="41300" checksum="C6134FD23646EB5F" modified="2017-01-18" version="1">MKYIEEFNDPGLARRLLEDIRATVTRPWALMEVCGGQTHSIIRHGIDQLLPEDVELIHGPGCPVCVTPLEAIDRALAIAARPEVTFCSFGDMLRVPGTDRDLYRVKGAGGDVRVVYSPLDALRIAQENPQREVVFFGIGFETTAPANAMAVHQARRLGVRNFSLLVSHVRVPPAIEAIMSSADCRVQGFLAAGHVCSVMGTTEYPELAERHRVPIVVTGFEPLDLLEGIRRAVRQLERGEHRVENAYPRAVQDTGNPAALRMLQEVFTVTDRAWRGIGTIPGSGWRLSDAYRDFDAEHRFDVTGVTTRESARCRSGEVLQGLIKPHECEAFGTACTPRTPLGATMVSSEGACAAYYLYRRLDPAVRRAEEAEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF68</accession>
    <name>A0A1E7NF68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1519"/>
    <dbReference type="EnsemblBacteria" id="OEV39350">
        <property type="protein sequence ID" value="OEV39350"/>
        <property type="gene ID" value="HS99_0001155"/>
    </dbReference>
    <dbReference type="OMA" id="ARDLNKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="529" mass="57269" checksum="9C7C54C643524AC5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF78</accession>
    <name>A0A1E7NF78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288866.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000558.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1533"/>
    <dbReference type="EnsemblBacteria" id="OEV39360">
        <property type="protein sequence ID" value="OEV39360"/>
        <property type="gene ID" value="HS99_0001230"/>
    </dbReference>
    <dbReference type="OMA" id="ATAPWDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018727">
        <property type="entry name" value="DUF2267"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10025">
        <property type="entry name" value="DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="14721" checksum="FA606D8C8E05DA40" modified="2017-01-18" version="1">MTIRWEAFLDQVRERGEYSTPEEAERCARVVLALLGAHLVGDVRTRLAARLPETLALVLLNPLQAAEPLSPERFVRATAAWIEGATEATALWDIGAVLSTVADAADDQLMEQVLLQLPPGYDVLFGRPDAVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF96</accession>
    <name>A0A1E7NF96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS alpha-glucoside transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0001340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556033.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1557"/>
    <dbReference type="EnsemblBacteria" id="OEV39379">
        <property type="protein sequence ID" value="OEV39379"/>
        <property type="gene ID" value="HS99_0001340"/>
    </dbReference>
    <dbReference type="OMA" id="VAHCMTR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="125"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV39379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="485" mass="48630" checksum="4D0777719191B19C" modified="2017-01-18" version="1">MSDEKHRAVAEAILPLVGGAANIRSVAHCMTRLRLGLADRSLVDREALGALPAVLGTVEDDTYQIVLGPGAVAGVTAQLRRLLDSGGDPAPAAAAPGAEDLAGRGARIRAEARVRNATPVKRMLRRIANVFVPLIPALIGCGIVAALAGALANLEWAPGLVTALGPVSSGFMSLIAVFVGYNTAKEFGGTPVLGGAVASVTVYAGVAKVEAFGHHLTPGQGGVVGALLAALLAVRLEQWTRRVVPEALDVLVTPTVTVLFGGLAALFGLMFVAGEVSTAIGHAATWLLAHGGLLAGLVLGGLFLPLVMLGLHQALIPIHTTLIQQQGSTVLLPILAMAGAGQVGCAAAVYLRLRHNTSVRATIRSALPAGLLGIGEPLVYGVTLPLGRPFVTACVGGAAGGAFVGAAGQLGGAVGSTAVGPSGWALFPLLAGPHGMAAGAAVYGGGLLTGYAVGFLGTYFFGFTRETLAEYNAAAAEPAPALAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC4</accession>
    <name>A0A1E7NFC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556019.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1546"/>
    <dbReference type="EnsemblBacteria" id="OEV39372">
        <property type="protein sequence ID" value="OEV39372"/>
        <property type="gene ID" value="HS99_0001295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12224" checksum="0D13D43C44C5AE2F" modified="2017-01-18" version="1">MDALRRSLETARKGEPADAPEKGRRADRSQAARAGRSPKPTGGKKSTAAKGGTARSSKRAGATGGATGKPQLSGLTKAERYQRATDLDIPHRSTMTRDELQEALEHAGRSRRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD3</accession>
    <name>A0A1E7NFD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0001455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000106_gene5845"/>
    <dbReference type="EnsemblBacteria" id="OEV39397">
        <property type="protein sequence ID" value="OEV39397"/>
        <property type="gene ID" value="HS99_0001455"/>
    </dbReference>
    <dbReference type="OMA" id="TCIMITH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27315" checksum="A0677449E8E1E7C9" modified="2017-01-18" version="1">MTGAPVLALRGVSKRFGAVQALTDVHLEVHAGEVVALVGDNGAGKSTLVKTIAGVHPIDEGTIEWEGEAVSIARPHDAQALGVATVYQDLALCDNLDVVGNLFLGRELKRFGTLDEVAMEKRARELLDTLSIRIPSVRIPIAALSGGQRQVVAIARALVGDPKIVILDEPTAALGVEQTAQVLDLVERLRGRGLGVILISHNMADVKAVADTVAVLRLGRNNGVFEVAGTSHEEIISAITGATENAVTRRQARLAEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM0</accession>
    <name>A0A1E7NFM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367007.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3620"/>
    <dbReference type="EnsemblBacteria" id="OEV39283">
        <property type="protein sequence ID" value="OEV39283"/>
        <property type="gene ID" value="HS99_0000775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="277" mass="28525" checksum="AF3EF316EDF61469" modified="2017-01-18" version="1">MPASVLLAGAAVHGASAVGRDVVAFLDYFAGVFTLLSLTAAVVSGLAATDRLFLTPRLRVAVQSVHRATAVAALGFLAVHIAVKVAERHCDPLSTVLPFTGGTALAVSLGTVSADLLVLVAATGAFRGRFAGSRHAWLWRVLHAGAYACWPIALVHGLAAGRAAHAWVLWGYGLCAAVVALALLVRTLSWVGHRRTVTRHRRRSKAQPAGAPLPATAHGATVLPTTAHAVTTPVLPTTAQAATAHATARTGAVRRRPLHPVPVPPSRPGLIQPGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS1</accession>
    <name>A0A1E7NFS1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555634.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6761"/>
    <dbReference type="EnsemblBacteria" id="OEV39537">
        <property type="protein sequence ID" value="OEV39537"/>
        <property type="gene ID" value="HS99_0002300"/>
    </dbReference>
    <dbReference type="OMA" id="MSETENG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="34879" checksum="23A1371B2DD75D4A" modified="2017-01-18" version="1">MRAAIGDRVIVEGTRPGVPRRDGRVTALHRPDGEPPWEVLWSDTGHSTLFFPGPDSRLHHFTRQAPSRQAPRPSVRPRTSSKTERSEPARPEEPTGGQEQAMPSNPGDLGRRVALRREQLGLSREQTAVRAGMAVRYLEYLETSPTAVERGALARLAAVLDTSVTQLLGGGLDLPPGRTSAAAHPVLEELARSECWERLSTDGVGRVALGTATGPIVLPVNYWVLDGTLIFRTAADGPLAATVGQRVAFEVDRIDEVLRTGWSVLATGDAHRIDDRPALAHLKQQDKPSPWAGGERDVWVRIKPTELSGRVIRTADDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT4</accession>
    <name>A0A1E7NFT4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase SNF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481229.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000107.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5053"/>
    <dbReference type="EnsemblBacteria" id="OEV39508">
        <property type="protein sequence ID" value="OEV39508"/>
        <property type="gene ID" value="HS99_0002110"/>
    </dbReference>
    <dbReference type="OMA" id="HRMGQVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="298"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="539"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="722" mass="79013" checksum="11D8C0F1121BCB34" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD1</accession>
    <name>A0A1E7NGD1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550522.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000236.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2945"/>
    <dbReference type="EnsemblBacteria" id="OEV39771">
        <property type="protein sequence ID" value="OEV39771"/>
        <property type="gene ID" value="HS99_0003740"/>
    </dbReference>
    <dbReference type="OMA" id="ADWLCHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="21001" checksum="9BD07E01FB9427D5" modified="2017-01-18" version="1">MTTGPSDDVKNASRRFLLYGVLPLWFAPAVGDWVMHRRSHIEDTSGLRESLVHALMMAEAGTPVVLGLVAEINPLVLATMGAAALAHGATALWDVTIATGRRDVTPFEQHIHSFLEVLPLTAVAFTACLHWDQVRSLARGGGTRRAWRLNPKPHPLPARYLTGFAVATAALVALPYGEELLRCARAERRRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH4</accession>
    <name>A0A1E7NGH4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1528"/>
    <dbReference type="EnsemblBacteria" id="OEV39811">
        <property type="protein sequence ID" value="OEV39811"/>
        <property type="gene ID" value="HS99_0001205"/>
    </dbReference>
    <dbReference type="OMA" id="VIEFAFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="148"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="30371" checksum="F6EB9A28E9F580F3" modified="2017-01-18" version="1">MPGTSTGPVVVGFDGSPESLTATEWAAREAERRDRPLEVLEAWPWPKRDVVGSDQTYHRALAHLADRESALSALVPGVPVSTAPVSADPVEALEEASHRAAVLVLGSRGLGTLRGFLVGSVSQEVLRRSACPVVLVRAREDEPDGSVTAGIDLVHPAGHVLAFAFQAAALRSAPLRVIHVWSPPAGSEYMSYGAIGGLEGELSSVEWSGLAEALEPLRARYPEVEVTADLVRGKPAVELVDAAASARLLVLGRRLRHLPFRHHHLGPVAHAAIHHVHCPVAVVPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGJ6</accession>
    <name>A0A1E7NGJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556041.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1561"/>
    <dbReference type="EnsemblBacteria" id="OEV39814">
        <property type="protein sequence ID" value="OEV39814"/>
        <property type="gene ID" value="HS99_0001360"/>
    </dbReference>
    <dbReference type="OMA" id="KMIRHED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9255" checksum="C709F81B1E135718" modified="2017-01-18" version="1">MKASKIAYRPVALVLGAVSGMAAGALFKQTWKALGHGEDAPDATDEDRSWREVLLTATLQGAIFAGVKAAVDRVGATTVRRLTGTWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV75</accession>
    <name>A0A1E7MV75_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme PQQ synthesis protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738033.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32329">
        <property type="protein sequence ID" value="OEV32329"/>
        <property type="gene ID" value="HS99_0016635"/>
    </dbReference>
    <dbReference type="OMA" id="AVECHRT"/>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011725">
        <property type="entry name" value="PQQ_synth_PqqA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02107">
        <property type="entry name" value="PQQ_syn_pqqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="56" mass="5907" checksum="560EBEBF3FC31377" modified="2017-01-18" version="1">MDAARTPSPPPKATAAPTARPKGARPAWSAPAVECHRTGAEVTAYAGRRAPQWPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVC4</accession>
    <name>A0A1E7MVC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulose phosphate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553858.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6978"/>
    <dbReference type="EnsemblBacteria" id="OEV32381">
        <property type="protein sequence ID" value="OEV32381"/>
        <property type="gene ID" value="HS99_0016935"/>
    </dbReference>
    <dbReference type="OMA" id="YYDEQLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="26161" checksum="A84DB788CBDAA01F" modified="2017-01-18" version="1">MKNIDAPETDDEAAELTALGSRVLAEAGHGDMIWGHLAVRDPGGRGVWMKAAGWGLEEIEPERVVLVSWDGERLSGDGPLHLEFHIHTEVMRARPDVQVSVHTHSGTVNAFASVGEPLRPLSHDAVAFAEHGLPNFGATANLIRTQELGRALAADLGPARACLMPQHGLLTVGPDIAHAVMYAVLLERACGLQLAARAAGGPRHWTGHQESLEKDALVWASGQIAAGWRYWVRRTERRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVF6</accession>
    <name>A0A1E7MVF6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291013.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000501.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32404">
        <property type="protein sequence ID" value="OEV32404"/>
        <property type="gene ID" value="HS99_0017065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="13596" checksum="7C7ACBE1E9421A80" modified="2017-01-18" version="1">MDRDHAYRDYPFADGHNVLWELEGYGSDDRQHSSRLLGREEYLRIRHLFAAELGDDDWMMAGGYPVPAQLWRPVQDLLGPPGFEDGLDYFLGARQNLPDGRIWRPAPDFGTPPGRTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM0</accession>
    <name>A0A1E7MVM0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0017525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290118.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1228"/>
    <dbReference type="EnsemblBacteria" id="OEV32479">
        <property type="protein sequence ID" value="OEV32479"/>
        <property type="gene ID" value="HS99_0017525"/>
    </dbReference>
    <dbReference type="OMA" id="MRYWSIS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="44580" checksum="F2FFAAEBA2D49664" modified="2017-01-18" version="1">MATAAQTPRFTHPAARGTCPFAPPPAYRQAQQEEPVSRITLWDGSASWLATRHEDVKAVLADPRFSADSTRPGFPFLTAGVRQLNAGRPTFIRMDDPEHARLRRMLTGDFVIKKVEALRPRIQRIADDLLDRMTADGRTGADLVREFALPLPSLVICLLLGVPYQDHEFFQECSRVMLRRESSAEEVGAAQDRLVDYLNRLTEAKRTQPDDGILSRLVERGELTTAEIGAMGRLLLVAGHETTANMTALSVLALLRNPDQLDHLRRHPEAVTGAVEELLRYLTIVHSGLGRVATEDVDLGAVRIRAGEGVVCMISTANRDEDEFPDGDELDLTRDARRHLAFGFGVHQCLGQPLARLELQIALATLLRRLPELRLAVPFEDVRFRGDMLIYGVHELPLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP9</accession>
    <name>A0A1E7MVP9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289871.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6865"/>
    <dbReference type="EnsemblBacteria" id="OEV32506">
        <property type="protein sequence ID" value="OEV32506"/>
        <property type="gene ID" value="HS99_0016390"/>
    </dbReference>
    <dbReference type="OMA" id="KRYVPLM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="16772" checksum="4458F7861749B7D5" modified="2017-01-18" version="1">MPLEGEYEPSPAQWVREQVELYESSGGTQGATLRDTGLPVVIVTMRGAKSGKIRKVPLMRVEHEGRYAAVASKGGFPHHPVWYFNLKADPHVDLQDGAERRAMTARELTGEEKDQWWQRAVAAYPPYAEYQEKAHREIPVFVLEPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVX4</accession>
    <name>A0A1E7MVX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0040025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000088">
        <property type="protein sequence ID" value="OEV32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279096.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7048"/>
    <dbReference type="EnsemblBacteria" id="OEV32571">
        <property type="protein sequence ID" value="OEV32571"/>
        <property type="gene ID" value="HS99_0040025"/>
    </dbReference>
    <dbReference type="OMA" id="TLNMVYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="159"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="29930" checksum="EF1704F20E508708" modified="2017-01-18" version="1">MDITTTQTTVKFDVKVVAAASTTVVLWASAFVAIRDAGGAFGPGALALGRLLTGALALLALLLVRGEGLPPRAAWPGILTSGVLWFGLYMVALNWGEEKVDAGTAAMVVNIGPVLIALLGGWLLKEGFPRSLLAGMAVSFAGAIVVGASTSGGGGSSVLGIVLCVLAAAAYASGVVSQKPALRHASPLQTTAFGCLVGAVACLPFSPQLVDQVGHAPLRAVLDMVYLGLFPTALAFTTWAYALSRTTAGKMGATTYAVPALVVLMSWAVLGEVPGWLTLLGGVLCLGGVAVSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWK6</accession>
    <name>A0A1E7MWK6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32826">
        <property type="protein sequence ID" value="OEV32826"/>
        <property type="gene ID" value="HS99_0039995"/>
    </dbReference>
    <dbReference type="OMA" id="RASHLLW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="29432" checksum="303305AD38FF8CA0" modified="2017-01-18" version="1">MRRPERIPAPLLCLVAMFLVQTGIALSKPLFGPLGVSGTTFLRLGFAAAILLAVTRPRLRDKRPRDLAAAALLGVASAGMTYLFAGAIDRLPMGTAATIEFLGPLAVALVFARRASHLLWALLAAAGVVLLTLLGEGDGGGSLDPVGLLYAFGAAACYAVYILFTDKVGATFQGFQGLAVSMTVGALALAPFGFGEARDGLTAPGASPLVLLASVAGVAVLLPVLPYALEMTALRRMPQRVFSVLVSLEPAVSALVGLVVLGQLLGAAQLAGIGCVVAASVGATLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWY0</accession>
    <name>A0A1E7MWY0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81347">
        <property type="protein sequence ID" value="ARF81347"/>
        <property type="gene ID" value="B6264_22735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32937">
        <property type="protein sequence ID" value="OEV32937"/>
        <property type="gene ID" value="HS99_0013715"/>
    </dbReference>
    <dbReference type="OMA" id="HDEENDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8063" checksum="3A15A3226A7BBC88" modified="2017-01-18" version="1">MPALVVIHDGEGDWLIGDGVNDPNLPGSSDVYCIACTTENDPSLSELAGLPPGFAAFRDGPGLPWTVEPFSYEGEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXF9</accession>
    <name>A0A1E7MXF9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550932.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2683"/>
    <dbReference type="EnsemblBacteria" id="OEV33128">
        <property type="protein sequence ID" value="OEV33128"/>
        <property type="gene ID" value="HS99_0014860"/>
    </dbReference>
    <dbReference type="OMA" id="HSWVFNG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="421" mass="45979" checksum="A7D76D45C751E527" modified="2017-01-18" version="1">MTTTPQAPRFGVNYTPSAGWFHHWLDFDLDAVRADFDSIAALGLDHVRVFPLWPLFQPNRTLIRPRAVEQLTALVDAAGERGLDVAVDGLQGHLSSFDFLPSWTRTWHRRNIFTDPEVLDGQAAYLRTLAGALRERPNFLGMTLGNEINQFSGGPHPDPDEVTPAEAEAWLRRMLAACERGAPGRLHLHASYDAAWYLDGHPFTPWHSARLGAATAVHSWVFNGTAQRYGPHSTATAQHAAYLVELSKAWADDPGRPVWLQEVGAPAPHITAEDAARFTGATVDAVLDCPDLWGVTWWCSHDVDRSLADFPDLEYSLGLLTTERAVKPAGARLAGAVAEARRDWQPPQPRSTAVVVATGDEVTSPRRAVCGPGGPVYEAFMHLAEAGARPTTVLAERAGDRAHLAARGITEVVRPSDVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXG2</accession>
    <name>A0A1E7MXG2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000392.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2684"/>
    <dbReference type="EnsemblBacteria" id="OEV33127">
        <property type="protein sequence ID" value="OEV33127"/>
        <property type="gene ID" value="HS99_0014855"/>
    </dbReference>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="519"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1013" mass="110444" checksum="3FA350A918909D14" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY48</accession>
    <name>A0A1E7MY48_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283890.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3400"/>
    <dbReference type="EnsemblBacteria" id="ARF80445">
        <property type="protein sequence ID" value="ARF80445"/>
        <property type="gene ID" value="B6264_17395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33344">
        <property type="protein sequence ID" value="OEV33344"/>
        <property type="gene ID" value="HS99_0012165"/>
    </dbReference>
    <dbReference type="OMA" id="KIFQWAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="645" mass="69428" checksum="E90A09AEF75013B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY53</accession>
    <name>A0A1E7MY53_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="10" type="ORF">HS99_0012265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290771.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4034"/>
    <dbReference type="EnsemblBacteria" id="ARF80464">
        <property type="protein sequence ID" value="ARF80464"/>
        <property type="gene ID" value="B6264_17495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33362">
        <property type="protein sequence ID" value="OEV33362"/>
        <property type="gene ID" value="HS99_0012265"/>
    </dbReference>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="309" mass="33928" checksum="D72B48D88895F074" modified="2017-01-18" version="1">MNAPSSSYRSGFACFVGRPNAGKSTLTNALVGTKVAITSDRPQTTRHTVRGIVHRPDAQLVLVDTPGLHKPRTLLGERLNDLVRTTWAEVDVIGFCLPADQKIGPGDKFIAKEIAGIKKTPKVAIVTKTDLVDSKRLAEQLIAIQQLGVELGFEWAEIIPVSAVGDKQVELVADLLTKLLPEGDQLYPEGDLTDEPEQIMVAELIREAALEGVRDELPHSLAVVVEEMLPREGRPADRPLLDIHANVYIERQSQKAIVIGAKGSRLKHVGTTARKHIEALLGTPVYLDLHVKVAKDWQRDPKQLRKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY59</accession>
    <name>A0A1E7MY59_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33173">
        <property type="protein sequence ID" value="OEV33173"/>
        <property type="gene ID" value="HS99_0014750"/>
    </dbReference>
    <dbReference type="OMA" id="DYPAFTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="12437" checksum="A8581FCCD453DF1F" modified="2017-01-18" version="1">MRPHTPDSLDDDDYPAYTMGRAAEMTGTTPGFLRSLGEHGLITPLRSEGGHRRYSRYQLRIAMRARDLVDQGTAIDAACRIIILEDQLEEALRINEQLRSSQHGQEPAADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYB0</accession>
    <name>A0A1E7MYB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287533.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000343.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3955"/>
    <dbReference type="EnsemblBacteria" id="ARF80533">
        <property type="protein sequence ID" value="ARF80533"/>
        <property type="gene ID" value="B6264_17900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33428">
        <property type="protein sequence ID" value="OEV33428"/>
        <property type="gene ID" value="HS99_0012675"/>
    </dbReference>
    <dbReference type="OMA" id="CDKIVFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20575" checksum="12193AF446EE12A2" modified="2017-01-18" version="1">MVVTLAKGGNVSLTKAAPNLTQVQIGLGWSARSTTGAPFDLDASALICGGGRVLGDEYFVFYNNLKSPEGSVEHQGDNLVGGDDTGDDELVLVNLELVPAQADKVVFAVSIYEAEARLQNFGQVRNAYIRVVNSVDGQEIARYDLSEDASNETAMIFGELYRYAGEWKFRAVGQGYASGLRGIALDFGVNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYE0</accession>
    <name>A0A1E7MYE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555513.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6574"/>
    <dbReference type="EnsemblBacteria" id="ARF80543">
        <property type="protein sequence ID" value="ARF80543"/>
        <property type="gene ID" value="B6264_17975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33439">
        <property type="protein sequence ID" value="OEV33439"/>
        <property type="gene ID" value="HS99_0012750"/>
    </dbReference>
    <dbReference type="OMA" id="RFAVMAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11689" checksum="8C8D2860A6B91C44" modified="2017-01-18" version="1">MSHPRWSLDTVIHAPIRLSITAALAAVDEADFKSIREAVEITDSALSKQIALLEEAGYVQVRKTFVGKRGRTWLSLTKAGRTALDRHLNALREIAGWDAEDTRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYJ9</accession>
    <name>A0A1E7MYJ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0013225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282557.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5193"/>
    <dbReference type="EnsemblBacteria" id="ARF80618">
        <property type="protein sequence ID" value="ARF80618"/>
        <property type="gene ID" value="B6264_18445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33515">
        <property type="protein sequence ID" value="OEV33515"/>
        <property type="gene ID" value="HS99_0013225"/>
    </dbReference>
    <dbReference type="OMA" id="DPESMFD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="28960" checksum="31A3798DA5AF1AE8" modified="2017-01-18" version="1">MTTATLTPARAGTGADDTRIGAAGTLRHIGALTRRNLMRIKADPESMFDAVLMPIVFTLLFVYVFGGAIAGGQDSYIQRLIPGLLGQTGMTLALAVGTGLNSDFQTGVMDRFRTLPIGRASVLLSKLAAESLRALLSSAILLGFAFVLGFEVKTGVLEVLATVGLSLVFGMSIVWISMLLGMALRSPQAVQGVSMLVLMPMQFGSSIFAPTDTMPGWLQTFTEVNPLSQLADASRALLNGEGAVAHPVMVVLIWSAVSTAIFAPLAVARFRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYR1</accession>
    <name>A0A1E7MYR1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ArsC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282676.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5245"/>
    <dbReference type="EnsemblBacteria" id="ARF80664">
        <property type="protein sequence ID" value="ARF80664"/>
        <property type="gene ID" value="B6264_18700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33559">
        <property type="protein sequence ID" value="OEV33559"/>
        <property type="gene ID" value="HS99_0013480"/>
    </dbReference>
    <dbReference type="OMA" id="MQRPIVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03034">
        <property type="entry name" value="ArsC_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006659">
        <property type="entry name" value="Arsenate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="13619" checksum="ECCD0C77CD3931A1" modified="2017-01-18" version="1">MEIWINPRCSKCRTALTELDAAGVEYTVRRYLEDTPTVAELEQVLERLGLEPWDITRTDEQVAKDLGMKDWPREAGERARWIAAMAEHPVLIQRPIITADDGHAVVARTPEALKSVLPQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ33</accession>
    <name>A0A1E7MZ33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0038185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551955.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1931"/>
    <dbReference type="EnsemblBacteria" id="ARF79611">
        <property type="protein sequence ID" value="ARF79611"/>
        <property type="gene ID" value="B6264_12450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33710">
        <property type="protein sequence ID" value="OEV33710"/>
        <property type="gene ID" value="HS99_0038185"/>
    </dbReference>
    <dbReference type="OMA" id="WWWADPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="20964" checksum="170FC4E6AF447FF4" modified="2017-01-18" version="1">MGAVGVPRAALLRRGFALEYATLGWNVVGTVILAIAAIGARSVALAGFGLDSLIEIGASTVVIWELSGSGEDRQKRALRLIGVGFALLAVYLLVQSTWVLASSFRPHHSTLGIVWTAITVAVMFALAFGKARTGAALDNPVLKTEGRVTLIDGLLAAAVLLGLVLNTTLGWWWADPAAGYVLVYYAAREVKEIFFGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N043</accession>
    <name>A0A1E7N043_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chemical-damaging agent resistance protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280061.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2312"/>
    <dbReference type="EnsemblBacteria" id="ARF77917">
        <property type="protein sequence ID" value="ARF77917"/>
        <property type="gene ID" value="B6264_02360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34060">
        <property type="protein sequence ID" value="OEV34060"/>
        <property type="gene ID" value="HS99_0011510"/>
    </dbReference>
    <dbReference type="OMA" id="WDVRTTS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20278" checksum="F74B24ACDDA0AC98" modified="2017-01-18" version="1">MGVSLAKGGNVSLSKEAPGLSAVIVGLGWDVRTTTGADYDLDASALLCNALGKVVSDQHFVFFNNLRSPEGSVEHSGDNLTGGGDGDDEQIKVDLARVPADVAKVVFPVSIYDADARLQNFGQVRNAFIRIVNQANGQEIARYDLSEDASTETAMVFGELYRNGGEWKFRAIGQGYASGLRGIATDYGVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N069</accession>
    <name>A0A1E7N069_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000805.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2343"/>
    <dbReference type="EnsemblBacteria" id="ARF77947">
        <property type="protein sequence ID" value="ARF77947"/>
        <property type="gene ID" value="B6264_02515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34088">
        <property type="protein sequence ID" value="OEV34088"/>
        <property type="gene ID" value="HS99_0011660"/>
    </dbReference>
    <dbReference type="OMA" id="EFEPMHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3533" evidence="1">
        <location>
            <begin position="31"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="432" mass="44624" checksum="19E2AA8AB845992B" modified="2017-01-18" version="1">MATTGSPGAPRQARALALARRPKLWLFPSVLCALVAVLLSLLYMGGIVNPNGNLHRLPIALVNADRGAPPPGRAVNSGTELTRAVVAGTPGETVDWKQTDEAGAHDLISSGKVYAALLVPADFTAAVTGLATGGATARPTLTVLTNPALGSLGASMASQIAQGAAHQASLATGRQLLAAVPATKSSGPDGGATARLLLADPFAVTTKAGPIGSHSGLGLSAFYYTLLSVLSGFIGGNIIHNGVDGALGYSDSEIGPWHTRRPTVPISRTQTLLLKMVMTAGIMLLTTSLVLLCTVGILGMDAPHMAMLWLFAYCASLAVGLGVQAINAAFGGIGQLVSMFVFIALALPSSGATVPLQAVPAFYRFLGAFEPMRQLSDGIRAILFFDARSDAGLARGWIMIAVGVVLALAFGFGMTRYYDRKGLHRWTPQPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A5</accession>
    <name>A0A1E7N0A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557270.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000100.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3705"/>
    <dbReference type="EnsemblBacteria" id="ARF77980">
        <property type="protein sequence ID" value="ARF77980"/>
        <property type="gene ID" value="B6264_02695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34119">
        <property type="protein sequence ID" value="OEV34119"/>
        <property type="gene ID" value="HS99_0011840"/>
    </dbReference>
    <dbReference type="OMA" id="PDNQHLG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="410" mass="45508" checksum="284C5357A6C8BECE" modified="2017-01-18" version="1">MTPGTLLQQITDYANRANPYPLYAELRKTPVARQDDGSYLVGGYYEISSLLHDPRISSDQRNLVARDGGGLQAEEEAGLPPSMIRTDPPEHDRLRRMAMRPFGPPHTPRRVHEMGGELHRIVSGLIDGFQGKDHVDIVDDFSYPFPVTVICRLLGVPREDESRFHVWADAMVGAADPSPSADLQERQRAGTRARTELGRYLAGLAEEHRRSPGDDLLSALATDHGPDGQMSMVELASTSVLLLIAGHETTVNLITNGMLTLLRYPEHLERLVKEPEVAVPMVEELLRYEPPVHLALPRVALADIEVKGTVIPRGSTVWLGLASANRDPRRFDDPDRFDPDRRDNQHLSFLGGIHNCFGSPLARLEAQIALTELARRLANPRLVEDPPPYRPNPLLRGPRHLAVAFDGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E3</accession>
    <name>A0A1E7N0E3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-siderophore ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0010590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1856"/>
    <dbReference type="EnsemblBacteria" id="OEV34141">
        <property type="protein sequence ID" value="OEV34141"/>
        <property type="gene ID" value="HS99_0010590"/>
    </dbReference>
    <dbReference type="OMA" id="LMIRQGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="34257" checksum="A5B840EA0B1C86B5" modified="2017-01-18" version="1">MTRRRARTAAWSLLALALLVLLTGVALGTGQVSISAWDALRALFGQGEPGNVLVVQQFRAPRVVSALIAGAGLAMAGSMLQRLFRNPLAAPDTIGITGGASFGAVLMLATGASQQLIPLAAVGGGLLAAMLLGGFAWRSKMAVTRLVLVGLAVQQGLAAAVNLMIVRFPAELASSAMQWTTGSLYGRNWTEVWIGGTAIALTAAALLLCQRRVAVLDLGDDSAGGLGLNPARDRLWLLLLTITLASLAAALTGPVAFVALAVPHLVRLLAGPPTLGTLGLTALTGAVLLLSADLLVLHVIPVHGLPVGAVTATLGAPWLLVLMIRQGRLPQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0M8</accession>
    <name>A0A1E7N0M8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6077"/>
    <dbReference type="EnsemblBacteria" id="OEV34250">
        <property type="protein sequence ID" value="OEV34250"/>
        <property type="gene ID" value="HS99_0036970"/>
    </dbReference>
    <dbReference type="OMA" id="RTRPVHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="86"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="22137" checksum="74045150F9135B5C" modified="2017-01-18" version="1">MSRDGERTDPGAGSVRKAPRLWAGRAATAAMVATVVLVVAGALLYDVVAVRAGQPARRWRAQVADELATRHLDDVWVLLGAGVSVLLGGWLLWLAITPGLRRWLVLRPYGGTDAAIERAGIGHLLADRAAGLRGIDHLRIRVGRRRVRVSVSGPVDPAVVQRQLREELGRVGLARPLRLDVRSWRGAAGGVADGAPDQPDDRAGEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N100</accession>
    <name>A0A1E7N100_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598034.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000647.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3923"/>
    <dbReference type="EnsemblBacteria" id="OEV34370">
        <property type="protein sequence ID" value="OEV34370"/>
        <property type="gene ID" value="HS99_0036225"/>
    </dbReference>
    <dbReference type="OMA" id="MRVDMCN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046238">
        <property type="entry name" value="DUF6271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19787">
        <property type="entry name" value="DUF6271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="47930" checksum="2F3FC616FBA0ADD3" modified="2017-01-18" version="1">MRAVCLALPTNRECADTVTAVGAEAAHAARRFGVRVHLLVLDSADPAARARHAAAAAALPPVEGVVVHHLDEDAQRAFLRGAIERSGLPGPDRLLDLMLPDAVSYGACTNRAFLLAAALGCTSVHRRDSDSRYQWHDGAPVFPIEHELATIGLKAADAAAAVTEHTLDPAHADKPVALVGASFIGELSVDLGEIRELDPETYHDVVALWAPTGATEEERRELVAESFTGAGTKPFTADRAVLDRPDIWRIDMCNIALDHEVYERVPLPPATDTIGSDYFLHHLVHDATLPGVTHNRHIVNYYTPERRTGSGFTAYQERYAKFLLSMLYLHPVYADMERAGDALLDEHHHVRPEAIADSARRSAATDRAENHRRLAELDRCYRRLGGKYAEFADHLAPARARLLDEAQADIEDFALLIDAWGPLVRASRATPADRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N182</accession>
    <name>A0A1E7N182_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0036820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285722.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000550.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6046"/>
    <dbReference type="EnsemblBacteria" id="ARF78139">
        <property type="protein sequence ID" value="ARF78139"/>
        <property type="gene ID" value="B6264_03720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34223">
        <property type="protein sequence ID" value="OEV34223"/>
        <property type="gene ID" value="HS99_0036820"/>
    </dbReference>
    <dbReference type="OMA" id="KELKGHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="25640" checksum="050D9EF50B6BFB9B" modified="2017-01-18" version="1">MTLWEAIAVLAAGVGAGMINVIVGSGTLITFPVLLAVGIPPVTANVSNSFGLVPGSLSGVIGYRRELVGQGRRLRRMGTASLLGGLLGALLLTKLPSGAFDAIVPALILLALVLVVIQPRVAKAVAARRRADGDPDGSLVLLAGVFLTGIYGGYFGAAQGVLLMALMGMMLQEDLQRINAVKNALAMIVNGVAALFFLFTSTVNWTAAGLIAAGSLVGGLLGAKVGRRLPPVVLRAVIVVVGLAAVTKLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1D7</accession>
    <name>A0A1E7N1D7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279030.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2580"/>
    <dbReference type="EnsemblBacteria" id="OEV34509">
        <property type="protein sequence ID" value="OEV34509"/>
        <property type="gene ID" value="HS99_0035515"/>
    </dbReference>
    <dbReference type="OMA" id="YVQTPVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198665" evidence="1">
        <location>
            <begin position="34"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="32748" checksum="E49117DA2C522C31" modified="2017-01-18" version="1">MTRRSPVKLRLVRRVVPLAAAVAALTAIPTASATQSTPARPGSHHQFAVGPQYDTTHVYVAPGTEQAFVTSWTSTFGGTTIGPVSTQVTPTPSRTLSELVVSPVGTLSVFDYTTPVPYPFGTERTGWLVTDLDQAVRAARADGAAVTVAPFADPIGRDAVVQFPGGISAQLYVHNAPTSYPALASVPENRLYLSPDSVRAFLDSYLAFTKGRIVSDDRHADGAAIGLPGTTYRLIRLTSGFGTTTVTVTDGHLPHPFGLETTGYGVPDLGATLDRAKTAGATVLWGPVSAGGQDSAMVRFPGGYIAEIHTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F2</accession>
    <name>A0A1E7N1F2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0035490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386633.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7077"/>
    <dbReference type="EnsemblBacteria" id="OEV34504">
        <property type="protein sequence ID" value="OEV34504"/>
        <property type="gene ID" value="HS99_0035490"/>
    </dbReference>
    <dbReference type="OMA" id="VMSFQEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33460" checksum="A5E1C32699479EA6" modified="2017-01-18" version="1">MRSRPRPATDPVPVRHGERWARWLFIAPAAAYLLLFFGYPVVENVVMSFQRYTVTTFYTGDAPFVGLRNYAAILSSSRFPRTLLTTAVFTVGSVLGQFAVGLALALFFRRRFPLGGVLRSLLLLPWLLPLVASGTTWKWMLDPDTGVVNAVLRGLHLSSSGVPWLTGTSQALLSVVLVNVWVGVPFNTAILYGGLQDIPPHLYEAAKLDGAGSLASFRHITWPLLRPVVSVVLVLGAVYTVKVLDIILVVTGGGPADATGTIATQSYELSFRQFDFGRGAAMGNLLIVLSLVFAVLYLRADRRARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1F8</accession>
    <name>A0A1E7N1F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0035600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388166.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2562"/>
    <dbReference type="EnsemblBacteria" id="OEV34529">
        <property type="protein sequence ID" value="OEV34529"/>
        <property type="gene ID" value="HS99_0035600"/>
    </dbReference>
    <dbReference type="OMA" id="HDITLWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_AT" evidence="6">
        <location>
            <begin position="567"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1493" mass="159337" checksum="0520089E2778D7F2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H1</accession>
    <name>A0A1E7N1H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835524.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000044.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N1H1"/>
    <dbReference type="EnsemblBacteria" id="ARF79324">
        <property type="protein sequence ID" value="ARF79324"/>
        <property type="gene ID" value="B6264_10690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34538">
        <property type="protein sequence ID" value="OEV34538"/>
        <property type="gene ID" value="HS99_0035170"/>
    </dbReference>
    <dbReference type="OMA" id="TWTAVMQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="692" mass="72001" checksum="504427337B8FB9E4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1K9</accession>
    <name>A0A1E7N1K9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558233.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7505"/>
    <dbReference type="EnsemblBacteria" id="OEV34579">
        <property type="protein sequence ID" value="OEV34579"/>
        <property type="gene ID" value="HS99_0008740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="111" mass="11990" checksum="6C7E0581A87C368E" modified="2017-01-18" version="1">MVDVPVVVDLPPLAGPARRAPSPEFKAHTGDDGEECGILCNSRLLTEGIDVAAVDAVCFADPKSSVIDIVQAVGRTLRLSYRQGNVSWIIPVYLPPRWSVTRQPAPTKRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N228</accession>
    <name>A0A1E7N228_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34760">
        <property type="protein sequence ID" value="OEV34760"/>
        <property type="gene ID" value="HS99_0009780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="9563" checksum="0E9D7FEA7C9D0903" modified="2017-01-18" version="1">MARAMVCHRPERVPSASPDRVPATETSVHGNPATRTQTGSTVLKSTWVISPRLGTPGQWCSRMAAAPGAGSACQAIWPPRTDCTPRSRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2D8</accession>
    <name>A0A1E7N2D8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7607"/>
    <dbReference type="EnsemblBacteria" id="OEV34851">
        <property type="protein sequence ID" value="OEV34851"/>
        <property type="gene ID" value="HS99_0010320"/>
    </dbReference>
    <dbReference type="OMA" id="PAVHERE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="160" mass="17935" checksum="F5DF1754EFF5C054" modified="2017-01-18" version="1">MQGGGVTAPTSSLRDHLGYWLRRLSDEVHGRFEKQLAEHGVTVSQWAVLITVYRGDATTTREVARYLDIDVGAVSRLVDRLVAKGLMSRESDPNSRRILRLTLTDAGLDLTPRLAEIADRNEAHFFAHLDPTRRLQLEDWIRRLVGDTHPETPASGRAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J0</accession>
    <name>A0A1E7N2J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4592"/>
    <dbReference type="EnsemblBacteria" id="OEV34885">
        <property type="protein sequence ID" value="OEV34885"/>
        <property type="gene ID" value="HS99_0009800"/>
    </dbReference>
    <dbReference type="OMA" id="SNARFQF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23474" checksum="FD9B38ED0EBE655C" modified="2017-01-18" version="1">MLAAAFTVSDTNTAEPAGGIAGWAVDTMDALGAAGAGLTNLVDTVLPFVPSEIVLPVAGFAAGQGRLNLAAVIVWTTVGSVAGSWIVYAAGALLGRERTRALAARIPLVSAHEIDRAEAWFARRGRTAVLLARMVPVVRSLISIPAGIQRMPFAAFTALTALGSLIWNTAFVLLGYWLGDNWQMVEEYGGWVSKAVVALALLAAARWFAVRLRRRPGARHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2K6</accession>
    <name>A0A1E7N2K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288617.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000644.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5884"/>
    <dbReference type="EnsemblBacteria" id="ARF82053">
        <property type="protein sequence ID" value="ARF82053"/>
        <property type="gene ID" value="B6264_27050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34928">
        <property type="protein sequence ID" value="OEV34928"/>
        <property type="gene ID" value="HS99_0035035"/>
    </dbReference>
    <dbReference type="OMA" id="GEQPAAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="17880" checksum="DB15279E5C39647D" modified="2017-01-18" version="1">MAIPPFLLELRSLVGNRPLWLSAVCAVVVDDRERVLLARRVDDGRWASVGGILDPGEQPADGVVRECLEETGVVVVPELLASTTVTRPVTYPNGDVTQYLVLTFRCRAVGGEARVNDDESLEVGWFALDELPPMLDFEHERLRHALECSGPAVFTWAGEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R5</accession>
    <name>A0A1E7N2R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557931.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000328.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4553"/>
    <dbReference type="EnsemblBacteria" id="ARF78507">
        <property type="protein sequence ID" value="ARF78507"/>
        <property type="gene ID" value="B6264_05910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34989">
        <property type="protein sequence ID" value="OEV34989"/>
        <property type="gene ID" value="HS99_0034850"/>
    </dbReference>
    <dbReference type="OMA" id="GPVMHLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26768" checksum="47AAE4DA770A6FE5" modified="2017-01-18" version="1">MTTAPHAVDASLRPGPAQLRLAALAGPLCTRYGLALAGGHALRAHGVPACPQDGLTLATGGADLPEVAAALAEAYRAAGGGVAERPGTPRLEQLAVRLALGGRSHSVELRKEPLAHRPVRLDFGVSEPGEPPVVLPVVALEDAAALTTALLVDRGMPRDLIDVHALTRNYREGELLALAAELDPDFQPDWLADRLETLAEAADGRFPARGVEAGAVEGLKRWALAWAQDLRLDLLETQQAADGLHDPYLEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y3</accession>
    <name>A0A1E7N3Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2388"/>
    <dbReference type="EnsemblBacteria" id="OEV35382">
        <property type="protein sequence ID" value="OEV35382"/>
        <property type="gene ID" value="HS99_0032755"/>
    </dbReference>
    <dbReference type="OMA" id="APPWSET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="16428" checksum="554B35EF0B975727" modified="2017-01-18" version="1">MDTCSPEELGELVPRSRDHRYDRLAADGLALGVRQTAALMELALTENGLHPDPAARLPVYGGARPAAGAEMLVLRPEQVAAASAFLRGSALGELVRQQNTVLARRVAQLDSAPPWSETWATRVVNDLRELRDFFAGAAAAGDAVVVRESAGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4B6</accession>
    <name>A0A1E7N4B6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetic acid degradation protein PaaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552733.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5484"/>
    <dbReference type="EnsemblBacteria" id="ARF79419">
        <property type="protein sequence ID" value="ARF79419"/>
        <property type="gene ID" value="B6264_11240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35530">
        <property type="protein sequence ID" value="OEV35530"/>
        <property type="gene ID" value="HS99_0032050"/>
    </dbReference>
    <dbReference type="OMA" id="CNTFPTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011975">
        <property type="entry name" value="PaaN_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02288">
        <property type="entry name" value="PaaN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="566" mass="59423" checksum="0F9C79C5469D444B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M5</accession>
    <name>A0A1E7N4M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene984"/>
    <dbReference type="EnsemblBacteria" id="ARF80797">
        <property type="protein sequence ID" value="ARF80797"/>
        <property type="gene ID" value="B6264_19475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35604">
        <property type="protein sequence ID" value="OEV35604"/>
        <property type="gene ID" value="HS99_0006705"/>
    </dbReference>
    <dbReference type="OMA" id="HTAWPYV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011746">
        <property type="entry name" value="Trp_synth-assoc_CHP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02234">
        <property type="entry name" value="trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="19835" checksum="3D48A873DC62D781" modified="2017-01-18" version="1">MTAADPTPAPAATAPATPAAGRRTLGVMLLLTVLSAVLVLTAVGRVWAEGRAGTLDVSVTGGRISELPGGLALVGLAAAVAVFAVRGVGRLAVGALTLLAGLGAAAASVAGASDTAALDSAASGKLALAGTTATEVSHTAWPWVALAGGLLLAAAGLITLRFGRGWPAMGSRYEAPTRKAPAKADTPGDLWKALDRGEDPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R1</accession>
    <name>A0A1E7N4R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock domain protein CspD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000376.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene898"/>
    <dbReference type="EnsemblBacteria" id="ARF80873">
        <property type="protein sequence ID" value="ARF80873"/>
        <property type="gene ID" value="B6264_19910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35676">
        <property type="protein sequence ID" value="OEV35676"/>
        <property type="gene ID" value="HS99_0007140"/>
    </dbReference>
    <dbReference type="OMA" id="TEEIFVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7418" checksum="BEE63E62B214E251" modified="2017-01-18" version="1">MATGTVKWFNSEKGFGFIEQDGGGPDVFAHYSNIVAQGFRELVEGQRVEFDVTQGQKGPQGENIQVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W7</accession>
    <name>A0A1E7N4W7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Macrolide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0031895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278179.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5515"/>
    <dbReference type="EnsemblBacteria" id="ARF79392">
        <property type="protein sequence ID" value="ARF79392"/>
        <property type="gene ID" value="B6264_11085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35503">
        <property type="protein sequence ID" value="OEV35503"/>
        <property type="gene ID" value="HS99_0031895"/>
    </dbReference>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MacB_PCD" evidence="7">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="6">
        <location>
            <begin position="311"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="40911" checksum="7E8315DF38B083B2" modified="2017-01-18" version="1">MILWQTLRFAVGGLAANKVRSALTMLGVLIGVASVILLLAVGNGSSQAVKDSITSLGTNSLTVSAGSAAGGSRSVSSVKKLTVADAKALATDADSSAIKSVAPVVTTSATALYGNVSYTPGSVVGTYPAYFETSNQKVAHGEYFTNDDVLGSRKVAVLGATTAKQLFDTEDPVGKKIVLGGTPFTVVGVLQAKGGSGFTDPDDVVIAPLPTVQNAFTGFGTVNQILVQASSADTTTAAQSEITRVLLGTHAIADPSKADFRITNQASLLTARESTTKTFTVLLGAVAAISLLVGGIGITNIMLVTVTERTREIGIRKALGAPRAVILGQFLTESTLLSVIGAGLGVAAGIVGSHFSIVGIKPVVIPASVLGAFGIAVAIGLFFGSYPANRAASLRPIDALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N553</accession>
    <name>A0A1E7N553_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550059.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5376"/>
    <dbReference type="EnsemblBacteria" id="ARF80776">
        <property type="protein sequence ID" value="ARF80776"/>
        <property type="gene ID" value="B6264_19355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35583">
        <property type="protein sequence ID" value="OEV35583"/>
        <property type="gene ID" value="HS99_0006590"/>
    </dbReference>
    <dbReference type="OMA" id="PLRIGTF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="295" mass="30565" checksum="6F801B59BE983A43" modified="2017-01-18" version="1">MLDVRRLRLLRELAHLGTIAAVAEALSFSPSAVSQQLSVLEKEAGVPLLERTGRRVALTPAGRGLVRHAESVLALLEQAGAELAHAKRGLAGPLRIGTYPSAARAIIPVVLGGLAAWHPGLEPMVTEVDPAAVGAALRAGELDVALVHEYDLVPADPEPGLAVTRPVFTEPMYLAARAPGTVAEQRGAPWILSPPGTLCHTMAVRACEAAGFAPRIRHQIDDFTTVLALVAAGQGVALVPHLGTAEPPPGVVLTRLPMYRRTRAAFRAGAGSHPAISAFVSALHTAVPPGLGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M1</accession>
    <name>A0A1E7N5M1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0008305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7230"/>
    <dbReference type="EnsemblBacteria" id="OEV35992">
        <property type="protein sequence ID" value="OEV35992"/>
        <property type="gene ID" value="HS99_0008305"/>
    </dbReference>
    <dbReference type="OMA" id="AHYTGWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="230"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="32825" checksum="3C79D1B8B6006229" modified="2017-01-18" version="1">MVNKDNSKDTSAAAQPDATKSAPPTPSAEPVPPIKDSAKVLPTVTGDFGKKADIQVPGDKSDGSFVVKVLSEGSGPKVDKNNWTSVDYTAKDWNTGKDIPSSYDDKGKPQIFQAGTDALIPALDQAVIGKKAGSRLLVVAPPAAGFGSQGKPDMSIGAKDDLIFVIDVRNTNAPDAVVSGTVTPPPADFPQVKDNGKKPAEITPVAGAKDPTELKTHVLIKGTGPVVEKGEKVVVQYTGALAKDGKVFDSSLSKGQAFSFAVGGGQVIQGWDQGLAGQTVGSRVELVIPASLGYGDKGQGDIPPGATLVFVVDILDAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6A3</accession>
    <name>A0A1E7N6A3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone biosynthesis decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284245.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8051"/>
    <dbReference type="EnsemblBacteria" id="ARF79834">
        <property type="protein sequence ID" value="ARF79834"/>
        <property type="gene ID" value="B6264_13800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36222">
        <property type="protein sequence ID" value="OEV36222"/>
        <property type="gene ID" value="HS99_0030745"/>
    </dbReference>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="485" mass="53785" checksum="812274BDA73BBE0C" modified="2017-01-18" version="1">MAYDDLRSFLRALDREGDLKRIKAEVDPHLEIGEIVDRVQKAKGPALLFENVKGSSMPLAMNVFGTERRLAKSLGLKGPEDVSEKIAGLLKPELPQGFTGFRDAFGKLASMAHVPPRQVKSGDAPVQEVVLTGDDVNLDELPALFTWPLDGGSFFNLGLTHTKDPDSGVRNLGLYRLQRHDRRTIGMHWQIHKDSRNHYAVAAKRGERLPVAIAFGCPPAVTYAATAPLPGDIDEYLFAGFIAGERVRMVDCKTVPLQVPADAEVVLEGWLEPGEMLPEGPFGDHTGFYTPQEPFPALTIDCVTMRRRPILQSIVVGRPPTEDGPLGKFTERFFLPLLKIIIPDIVDYDLPEAGGFHNCVIVSIDKKYPKHAQKTMHAIWGAHMMSLTKLIIVVDSDCDVHDYQEVAWRAFGNVDYSRDLTVVEGPVDHLDHASYQQFWGGKAGIDATRKLPEEGYTRDGGWPEMVSSDPATAALVSRRWKEYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R9</accession>
    <name>A0A1E7N6R9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0030005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554797.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82317">
        <property type="protein sequence ID" value="ARF82317"/>
        <property type="gene ID" value="B6264_28660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36392">
        <property type="protein sequence ID" value="OEV36392"/>
        <property type="gene ID" value="HS99_0030005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="75" mass="8020" checksum="611355A8FC6AA23B" modified="2017-01-18" version="1">MRPEAGERPGPVAESAEPRGPAPGTAEWHGPAVVLPLWRRWEGGEERRNADRPGVLRGHPGPVVSDQPEAAPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V2</accession>
    <name>A0A1E7N6V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene230"/>
    <dbReference type="EnsemblBacteria" id="ARF82258">
        <property type="protein sequence ID" value="ARF82258"/>
        <property type="gene ID" value="B6264_28325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36436">
        <property type="protein sequence ID" value="OEV36436"/>
        <property type="gene ID" value="HS99_0029290"/>
    </dbReference>
    <dbReference type="OMA" id="WQPVVQY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045981">
        <property type="entry name" value="DUF5937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19361">
        <property type="entry name" value="DUF5937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="39710" checksum="B2157654DB75113A" modified="2017-01-18" version="1">MSVTIDITGLPEERLLFSPSPLAELNAVLHVLSEPAHHPALHGWAASTTAAIPPELAERLLEADFLWRSSRADFLVPGLPGTTLAEELDAVDRLDDERYVASALITTCGASRFPYRLASPLTDPVANERARDLALARGPRQAAFAERLLADPPAVRALVRQLLEDCQSAFFADAWQRVLPDLAADARRKADLLARRGLAEAVAAMSPSVSLDERDGRRRIVIDKLQDSTASAADRGGVTFIPTVFGRPHLLAVYAQGWRPVLQYPVAEAGLPEPVSLALVQQRLEALAHPIRLRLARTIARGPHTTGELATAWQLSAPEVSRHLAVLRRAGLLITERRGRYMLYQLDLAGSARLGSDFLEAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N735</accession>
    <name>A0A1E7N735_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554212.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36485">
        <property type="protein sequence ID" value="OEV36485"/>
        <property type="gene ID" value="HS99_0029430"/>
    </dbReference>
    <dbReference type="OMA" id="HIELYQM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="37728" checksum="3E512F0D306F9968" modified="2017-01-18" version="1">MEYRRLGASGLKVPALSLGTGTFGGRGPLFGAWGTTDVQEARRLLDIAVDAGVTLFDTADVYSDGASEEVLGQAVRGRRDRVLISTKAGLPLGDGPQDAGTSRARLIRSVDDALRRLGTDYLDLFQLHAYDAATPIEEVLATLEDLVRAGKIRYTGVSNFSGWQLMKSLDLADRHGRPRYAAHQVYYSLVGRDYEWELMPLARQEGVGALVWSPLGWGRLTGRIRRGEPLPAGSRLHDTADYGPPVEDELLYRVVDALDGIAAETGRTVPQVAINWLLRRPTVSSVIIGARNEEQLRQNLGAIGWSLTEDQVARLDAASARTAPYPYFPYRRQAGFARLDPPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N798</accession>
    <name>A0A1E7N798_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7902"/>
    <dbReference type="EnsemblBacteria" id="ARF79130">
        <property type="protein sequence ID" value="ARF79130"/>
        <property type="gene ID" value="B6264_09545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36567">
        <property type="protein sequence ID" value="OEV36567"/>
        <property type="gene ID" value="HS99_0029040"/>
    </dbReference>
    <dbReference type="OMA" id="YLWRADA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="29025" checksum="46CB6C607D6320DC" modified="2017-01-18" version="1">MSRRLRYIGSNSDDNNCPTLYEDMKTGDVVVQGDAVTDPDEIAQLRKVKPGEGFVTVPRALLADFAPRDAEREPVLIGLDEFEDLFTTFQHTAYRLETRRRYRSDEQSETYRQFTAGQAPEWDLETPWCRSRREQSALGKRFERVRIMDNPPTPGQRYLLNNSERNGMVGEDIRYLWRADAERLGLPEEDAWLFDSRFIALLHFDSDDDLIHVELITDPVRVARACQERDAAWHYAVPHREFGAQVPSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F9</accession>
    <name>A0A1E7N7F9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7171"/>
    <dbReference type="EnsemblBacteria" id="OEV36413">
        <property type="protein sequence ID" value="OEV36413"/>
        <property type="gene ID" value="HS99_0029795"/>
    </dbReference>
    <dbReference type="OMA" id="FECTTAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="158"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="31797" checksum="EE7FDA0C4EBCC9F3" modified="2017-01-18" version="1">MAVVGLPAAPLRRFVLDYRGYRMSLDRPRRRLEVPTDVVTVALAFEGTMRLTDAVSPAPAVSFGSIAAGLRRTATIAEHAGALHGLAVSLTPQGAFRAFGPVAGELGGQWAEAGEVLGPRLDRLAARLADAPTWRARFALLDGYFTALLADGPVWEPDVVWAWHQLRRSRGLVPVRALVEGTGWSRRRLEQRFREQLGLAPKQAAGILRLQRTLRLLTAPDGRSARAADLAALCGYYDQSHLDRTFRGMVGCSPREFLASRRAAAATATAATGLEPVDRIVGRITSAVLDADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H8</accession>
    <name>A0A1E7N7H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386928.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000570.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82736">
        <property type="protein sequence ID" value="ARF82736"/>
        <property type="gene ID" value="B6264_09945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36594">
        <property type="protein sequence ID" value="OEV36594"/>
        <property type="gene ID" value="HS99_0028635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6442" checksum="064E13CE6DDBE25D" modified="2017-01-18" version="1">MSSTGGRSGGHDDAALDEIELTGELMIAATASTGERLPTERIDEVLLDRVDPARTEREGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T9</accession>
    <name>A0A1E7N7T9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0027545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284654.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4799"/>
    <dbReference type="EnsemblBacteria" id="OEV36766">
        <property type="protein sequence ID" value="OEV36766"/>
        <property type="gene ID" value="HS99_0027545"/>
    </dbReference>
    <dbReference type="OMA" id="SNYCINH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="14871" checksum="4BA3C37AD3594F8E" modified="2017-01-18" version="1">MRQQRIVVGVDGSPASVDALRWAIGQAGMQGAVVEALIAWQHPVATGWTVPIEAYEDLPGIARKILDDSVTEATDRDAAVEIKARVQEGGAAACLLEAAHGAELLVVGSRGHGGFAGALLGSVGQHCVQHAPCPVVVVRHRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V1</accession>
    <name>A0A1E7N7V1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552986.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4798"/>
    <dbReference type="EnsemblBacteria" id="OEV36765">
        <property type="protein sequence ID" value="OEV36765"/>
        <property type="gene ID" value="HS99_0027540"/>
    </dbReference>
    <dbReference type="OMA" id="CAREDWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="223" mass="24485" checksum="2F2BA851132E0C30" modified="2017-01-18" version="1">MRHRIVGELMTSAVVHVRPDTGFKEIARLLAEHDITAVPVLDQEDRPLGLVSEADLLLNEAAREDPAGLLLTPDLPPRERARSRATTAVGLMTAPAVCARPEWTVVEAARLMQSERVKRLPVVDEAGRLVGIVSRSDLLRVFLRHDTAIREEIRAEVLRRVLGIDPDALDVQVHNGRVTLTGTLDHHGQAPVVERLCRSVDGVVDLTSHLSHRTEAAALHQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Y9</accession>
    <name>A0A1E7N7Y9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7908"/>
    <dbReference type="EnsemblBacteria" id="ARF79124">
        <property type="protein sequence ID" value="ARF79124"/>
        <property type="gene ID" value="B6264_09515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36573">
        <property type="protein sequence ID" value="OEV36573"/>
        <property type="gene ID" value="HS99_0029070"/>
    </dbReference>
    <dbReference type="OMA" id="VITWFEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13172" checksum="B90F643CB12CADB5" modified="2017-01-18" version="1">MTTTKTARELAETYFSAWEAGDFDTLRGLLAEDVDFVGALGTASGIEEALGGLKGLGQVLEKIDVKVRVAEGDEVITWFELCSTVAPPAPTANWMHVENGKIARIRVTFDPRGLLAGFEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Z0</accession>
    <name>A0A1E7N7Z0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284719.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000282.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36827">
        <property type="protein sequence ID" value="OEV36827"/>
        <property type="gene ID" value="HS99_0027370"/>
    </dbReference>
    <dbReference type="OMA" id="DSWRFFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="27427" checksum="02B855EA303ED150" modified="2017-01-18" version="1">MAPQPTGTATGPHDAAFLPRRELSARPAEQPITEAVPKLGGEPCWLAEPAWPLSPDTGEPLVFIGQFPVPGEDERLAYLFLAEENGVMGGLDPESGDGVLLVQPGGRVPPFAVIGPPGTHGRTLWRRDGRHSAGGSKTDGNHADDAPTTPVEFHLDLLPLSPGADRAMDQRAAFQRYLRGEGPEVPFPDGAHVYDHLGGVPSFPTGRAGVPAPWRYLFSLSDAPDDGDPYFLNFGYGVGFGFLSPDGLEGRFSWENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8A3</accession>
    <name>A0A1E7N8A3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0027050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287046.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6840"/>
    <dbReference type="EnsemblBacteria" id="ARF78633">
        <property type="protein sequence ID" value="ARF78633"/>
        <property type="gene ID" value="B6264_06640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36921">
        <property type="protein sequence ID" value="OEV36921"/>
        <property type="gene ID" value="HS99_0027050"/>
    </dbReference>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="455" mass="48610" checksum="6CBF86174080096A" modified="2017-01-18" version="1">MAISVFDLFSIGIGPSSSHTVGPMRAARMFARRLRSEGLLDRVTGVRAELYGSLGATGHGHGTPKAVLLGLEDNSPRTVDVDQADKDVERIIAEKRLSLLGEHPVDFDPDTQLVLHRRRSLPYHANGMTLWAYAADGSTLLEKTYYSVGGGFVVDEDAIGADRVKPDDTVLRYPFRTGEELLRLTRETGLSISGLMLENEKAWRSEEEIRTGLLEIWSVMQECVRAGMTREGILPGGLKVRRRAAAAARALRAEGIGPANAMEWVTLYAMAVNEENASGRRVVTAPTNGAAGIIPATLHYYLNFIPGADDDGIVRFLLAAGAIGMLFKENASISGAEVGCQGEVGSACSMAAGGLAEVLGGTPEQVENAAEIGIEHNLGLTCDPVGGLVQIPCIERNGMASVKAVTAARMALRGDGRHHVSLDKAIKTMKETGADMKIKYKETSRGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8F6</accession>
    <name>A0A1E7N8F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0003795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene165"/>
    <dbReference type="EnsemblBacteria" id="OEV36971">
        <property type="protein sequence ID" value="OEV36971"/>
        <property type="gene ID" value="HS99_0003795"/>
    </dbReference>
    <dbReference type="OMA" id="TWQSWFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1657"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3183"/>
            <end position="3258"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4725"/>
            <end position="4800"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6266"/>
            <end position="6341"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="7740"/>
            <end position="7815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="5907"/>
            <end position="5941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="7705"/>
            <end position="7724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="5917"/>
            <end position="5939"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1695"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="3218"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4760"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="6301"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="7775"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="9000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="9000" mass="932627" checksum="EC2D65FB96BD7F18" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8J8</accession>
    <name>A0A1E7N8J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557874.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000330.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5984"/>
    <dbReference type="EnsemblBacteria" id="ARF81726">
        <property type="protein sequence ID" value="ARF81726"/>
        <property type="gene ID" value="B6264_25035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36999">
        <property type="protein sequence ID" value="OEV36999"/>
        <property type="gene ID" value="HS99_0003980"/>
    </dbReference>
    <dbReference type="OMA" id="VNKWERA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="220" mass="22791" checksum="1233D0D9031E6D99" modified="2017-01-18" version="1">MNSIPEPQLTLDGSEPLTPATVRTLDALCDAAEDATGATTPLVVAVTGAPAARMDVPLPLVNKWERAVRRLEKLAVPTVALVTGDCGGTALDVLLATDVRVATPDARLLPLAGAGTDEVWPGMALYRLANQAGVAATRRAVLFGDALDAERALALHLFDELAADPAAAFAPVFEKLTGGAGTGIRRQLMLDASTTSYEEALGRHLAACDRTLRAAVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8K3</accession>
    <name>A0A1E7N8K3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0004165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366120.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7471"/>
    <dbReference type="EnsemblBacteria" id="ARF81695">
        <property type="protein sequence ID" value="ARF81695"/>
        <property type="gene ID" value="B6264_24835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37030">
        <property type="protein sequence ID" value="OEV37030"/>
        <property type="gene ID" value="HS99_0004165"/>
    </dbReference>
    <dbReference type="OMA" id="LWMATEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="544" mass="57104" checksum="B673A464647BE5D9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y6</accession>
    <name>A0A1E7N8Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386667.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81582">
        <property type="protein sequence ID" value="ARF81582"/>
        <property type="gene ID" value="B6264_24135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37151">
        <property type="protein sequence ID" value="OEV37151"/>
        <property type="gene ID" value="HS99_0004855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13676" checksum="BF31060DCF929B76" modified="2017-01-18" version="1">MPAFKLRMRTSAAILAGAAGVTALGAAVVPAVASAADASPQAVAARIVPADQLASFSQIVSHESGWNVTATNPSSGSYGLGQALPASKMASAGADWKTNPATQIKWTLDYMNTRYGSPNAAWAFWQNHHWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z8</accession>
    <name>A0A1E7N8Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6216"/>
    <dbReference type="EnsemblBacteria" id="OEV37167">
        <property type="protein sequence ID" value="OEV37167"/>
        <property type="gene ID" value="HS99_0004940"/>
    </dbReference>
    <dbReference type="OMA" id="NPDDTQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="50" mass="5362" checksum="4F2C9ACFAFB7FE5B" modified="2017-01-18" version="1">MHGEEALMYDPNPDDARRDQVLRAAAACPVQAILVDQLEGRDAPAEASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N912</accession>
    <name>A0A1E7N912_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556604.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000238.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6191"/>
    <dbReference type="EnsemblBacteria" id="ARF81550">
        <property type="protein sequence ID" value="ARF81550"/>
        <property type="gene ID" value="B6264_23915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37185">
        <property type="protein sequence ID" value="OEV37185"/>
        <property type="gene ID" value="HS99_0005065"/>
    </dbReference>
    <dbReference type="OMA" id="CNYFNGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="327" mass="35252" checksum="265CD73D1DCE8AEE" modified="2017-01-18" version="1">MELRTLGNQGLTVSVEGLGCMGMSAFYGSTDEAESLATIDRALELGVTLLDTAESYGPFINEQLLGRALAGRREQAVLATKTGVEFTDDGTLVGLNGRPEYLRRALDRSLRHLGTDHVDLYYLHRVDPQVPIEETVGAMGELVAAGKVRHIGLCEAAPQTIRRAHAVHPVTAVQTEYSLFERGIEDDGVMATLDELGIGLVAYSPLGRGFLSGAITSPEDFAADDFRRTDPRFQGENFAHNLAVVGEVRRIAAAKQVTPSQLALAWVLHQGAVAIPGTKRRRYLEENVAATSVTITDEDLAAIEAVAPRGIVSGDRYAPELMRTLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N968</accession>
    <name>A0A1E7N968_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389696.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5967"/>
    <dbReference type="EnsemblBacteria" id="ARF81713">
        <property type="protein sequence ID" value="ARF81713"/>
        <property type="gene ID" value="B6264_24950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37013">
        <property type="protein sequence ID" value="OEV37013"/>
        <property type="gene ID" value="HS99_0004060"/>
    </dbReference>
    <dbReference type="OMA" id="VRTGMAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="23501" checksum="01902C2A965FC311" modified="2017-01-18" version="1">MIRTMIVDDQAIVRTGMAMILSVEDDITVVAEAEDGVQAVALAARHRPDVVLMDIRMPRLDGLDALRALTRPGALHMPRVVMVTTFDDDEYVTRALQSGACGFVLKDAGPRLLVEAVRAAAVGDSLISPAITVRLLERMMRTPPPQGAQAVLSPREFDVVRLVAQGLTNAEIAEALHITVGTVKTHLTNIQAKLSARNRVEVAAWAWRNGYAHHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9I9</accession>
    <name>A0A1E7N9I9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0006080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366187.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5442"/>
    <dbReference type="EnsemblBacteria" id="OEV37351">
        <property type="protein sequence ID" value="OEV37351"/>
        <property type="gene ID" value="HS99_0006080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="21478" checksum="2FF96CE81FE3992B" modified="2017-01-18" version="1">MAVRSDESAHPHDAVPSASAWSGNGRKPASRYRTRPGSLQALAIDSGRKAFRQSTWRHCSKGPMRSRFRVLTVRPAGVAARTHAMAQAGGAGTWDGVLPEATLLCEWPTGEKAPTEYWLTSLPADSPTRHLVRLAKMRWRLEHDYREMKHGLGLDHFEGRTWRGWHHHVTLVTAAHAFLTLRRLDPKVQAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA24</accession>
    <name>A0A1E7NA24_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnC</name>
        <name evidence="7" type="ORF">HS99_0026245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000760.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7992"/>
    <dbReference type="EnsemblBacteria" id="ARF79054">
        <property type="protein sequence ID" value="ARF79054"/>
        <property type="gene ID" value="B6264_09110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37518">
        <property type="protein sequence ID" value="OEV37518"/>
        <property type="gene ID" value="HS99_0026245"/>
    </dbReference>
    <dbReference type="OMA" id="ATMMFGS"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="44584" checksum="0E21EAAF164CEF5D" modified="2017-01-18" version="1">MTELAATTLDASSTDLQAVLDRAAAGGRITPEEALDLYRSAPLHALGSAADTVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYVPPKSDKGWSRELDEILRRCAETVELGGTQIMFQGGHHPDYGVEYYERAFSAIKAEFPQLVIHSLGASEVEHMSRISGVSIEEAITRIHKAGLDSFAGAGAELLPERPRKAIAPLKESGERWLEIMEAAHGLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPQNNHLKGSTQATVFEYLRMIAIARLFLDNIAHIQGSWLTTGKEAGQLSLHYGADDLGSVMLEENVVSAAGAKHRSNLTELIHLIRAADRVPAQRSTTYEHLRVLDDPANDPVDPRVASHIASTAIEGGTAHPELKILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAE6</accession>
    <name>A0A1E7NAE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280755.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1687"/>
    <dbReference type="EnsemblBacteria" id="ARF79924">
        <property type="protein sequence ID" value="ARF79924"/>
        <property type="gene ID" value="B6264_14325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37667">
        <property type="protein sequence ID" value="OEV37667"/>
        <property type="gene ID" value="HS99_0025535"/>
    </dbReference>
    <dbReference type="OMA" id="ANTRAWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="13904" checksum="3CB46F1CCCB1CBB1" modified="2017-01-18" version="1">MNHLWIQLILVVAAVAMALLFVRRWDAANTRAWKRIAFALFVIANVVAILWPSGVTKLATALGVGRGTDLVLYLMVIAMGFLTLNTYLRFRSLEKKLTDLARTVAITEGVRHNSDRLDTPVGSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAH3</accession>
    <name>A0A1E7NAH3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">HS99_0025635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280785.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1667"/>
    <dbReference type="EnsemblBacteria" id="ARF79943">
        <property type="protein sequence ID" value="ARF79943"/>
        <property type="gene ID" value="B6264_14425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37686">
        <property type="protein sequence ID" value="OEV37686"/>
        <property type="gene ID" value="HS99_0025635"/>
    </dbReference>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13515" checksum="04D4C19915F0AA1D" modified="2017-01-18" version="1">MSVSVKIGKGNAYKSAARKRRAIRVRKRVVGTEVRPRLVVTRSNRHMVAQVIDDAKGHTLASASTLDVSIKGAEGDKTELAKKVGSLVAERAKAAGIESVVFDRAGNRYAGRIAALADAAREAGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB18</accession>
    <name>A0A1E7NB18_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0024445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7088"/>
    <dbReference type="EnsemblBacteria" id="OEV37858">
        <property type="protein sequence ID" value="OEV37858"/>
        <property type="gene ID" value="HS99_0024445"/>
    </dbReference>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="31376" checksum="71368C76660AC44C" modified="2017-01-18" version="1">MNATEEESRGGFRVRLDNFEGPFDLLLSLIAKHKLDVTEVALATVTDEFLAHIRAMGPEWDLDAATEFLVVAATLLDLKAARLLPVAEVEDEADLALLEARDLLFARLLQYRAYKRAAALFGERWAAELLRRPRTVGLEPRHAELLPEVVITVGPERLAQMAAKAMEPKPKPVVYVDHIHTPPVSVREQASLVVDLLTGLGEASFQQLVADAPDTMVVVARFLALLELYRERVLAFEQPEALGELRVRWVAEEGRGAVEVTDEFDRPAGEPERSREEDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB49</accession>
    <name>A0A1E7NB49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0023910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552098.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2098"/>
    <dbReference type="EnsemblBacteria" id="ARF79471">
        <property type="protein sequence ID" value="ARF79471"/>
        <property type="gene ID" value="B6264_11580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37920">
        <property type="protein sequence ID" value="OEV37920"/>
        <property type="gene ID" value="HS99_0023910"/>
    </dbReference>
    <dbReference type="OMA" id="RDFLIWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="527" mass="57455" checksum="6CE089622C5C6948" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB56</accession>
    <name>A0A1E7NB56_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0023905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2099"/>
    <dbReference type="EnsemblBacteria" id="OEV37919">
        <property type="protein sequence ID" value="OEV37919"/>
        <property type="gene ID" value="HS99_0023905"/>
    </dbReference>
    <dbReference type="OMA" id="TYYDPAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="108"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="385"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV37919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="830" mass="88353" checksum="086232E5AA3D2E9F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB93</accession>
    <name>A0A1E7NB93_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ORF">HS99_0024175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278340.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000638.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2046"/>
    <dbReference type="EnsemblBacteria" id="OEV37962">
        <property type="protein sequence ID" value="OEV37962"/>
        <property type="gene ID" value="HS99_0024175"/>
    </dbReference>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
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        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="211"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="470"/>
            <end position="574"/>
        </location>
    </feature>
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        <location>
            <begin position="587"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
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        <location>
            <position position="512"/>
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        <ligand>
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            <position position="549"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <ligand>
            <name>substrate</name>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="751" mass="79938" checksum="3291E334EEA2703C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB94</accession>
    <name>A0A1E7NB94_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_LBHA01000259.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ARF79509">
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        <property type="gene ID" value="B6264_11805"/>
    </dbReference>
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        <property type="protein sequence ID" value="OEV37955"/>
        <property type="gene ID" value="HS99_0024130"/>
    </dbReference>
    <dbReference type="OMA" id="HVHRILQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="GerE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
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        <property type="entry name" value="HTHLUXR"/>
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        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21929" checksum="E75EF0B485CA81C9" modified="2017-01-18" version="1">MTENTAPVRVLLADDEHLIRGALAALLSLEDDIEVVAQAGSGPEALAMARAQRPDIAVLDLQMPGQDGIEVATELRRLLPDCRCMIVTGHGRPGYLKRALEVGVRGFLPKTVSAADLAGIIRTVRSGGRYVDPELAADAISAGETPLTPRETDVLELAADGTPIAEIAERAALSQGTVRNYLSSAATKLGAENRHAAVRIAREHGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBI8</accession>
    <name>A0A1E7NBI8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366501.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6026"/>
    <dbReference type="EnsemblBacteria" id="ARF78030">
        <property type="protein sequence ID" value="ARF78030"/>
        <property type="gene ID" value="B6264_03020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37833">
        <property type="protein sequence ID" value="OEV37833"/>
        <property type="gene ID" value="HS99_0024960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="42018" checksum="79AF8AA4C762B0A6" modified="2017-01-18" version="1">MSERPSAPTGTPTGPRRGTATVLTLGVVAALAFMPAVPDQRSGPVTPDAAATPSADATDPTVTVLGDGSTSDTGPQPGRPTPVRLKPGEQPPQFVVFSFDAPTEDDNHLFSRARTSAKASGADVTFFLRGIDLLPATKRWQYQPPQHEAGTAAVPFPTDAQVRATLQQLGRAWLDGDEIADGFIGQFCGPKGGRDWSTADWQSEIGQGYSMVNFWKTGTGFTDLPPLPFDYQTDLAGGRAPCLEGRPNLLPAEKDAGWRYDASSPGGTQRWPTQTDGTWDFPLQRIPDASDAHEVLSTDRTPQTYQNAFDRVYHGSRAPLVIDTDLDPRHAPELQSAETTMKDLCHRDGVRCVSFRQLADWLDAQDPTVLDRLRALGPTSSPNWAAAVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBK8</accession>
    <name>A0A1E7NBK8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0025100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556712.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000254.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5995"/>
    <dbReference type="EnsemblBacteria" id="OEV37853">
        <property type="protein sequence ID" value="OEV37853"/>
        <property type="gene ID" value="HS99_0025100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11640" checksum="73C80021B713A94A" modified="2017-01-18" version="1">MTQAAARNAPTSPQDGLWEAKLSEARDFSVAAAELPALTLRFPTRERFSWLLMKALYWSGRRADAIDAYHRTRRTLAEEYGVDPGAELQELFGSILRGDPIAGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBL1</accession>
    <name>A0A1E7NBL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288465.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79709">
        <property type="protein sequence ID" value="ARF79709"/>
        <property type="gene ID" value="B6264_13050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38080">
        <property type="protein sequence ID" value="OEV38080"/>
        <property type="gene ID" value="HS99_0023050"/>
    </dbReference>
    <dbReference type="OMA" id="FQVNRGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="8791" checksum="5AF699AF549D7474" modified="2017-01-18" version="1">MATNQTTSNGFQVNRSLLVGGVALAGIGSVLGAAGAALVCAALFSAGRSWVRGLEAAPAVLAQRALREAKVASAAGWEAWRAEHGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBW2</accession>
    <name>A0A1E7NBW2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552060.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000638.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2045"/>
    <dbReference type="EnsemblBacteria" id="ARF79517">
        <property type="protein sequence ID" value="ARF79517"/>
        <property type="gene ID" value="B6264_11855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37963">
        <property type="protein sequence ID" value="OEV37963"/>
        <property type="gene ID" value="HS99_0024180"/>
    </dbReference>
    <dbReference type="OMA" id="TDPLTWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28305" checksum="06F265C50E3233A6" modified="2017-01-18" version="1">MPPKSRTYQPQKVRAALAAQSESLRAVVHGLTADQLERPTRLGTWRVRELLTHLSLALGHLAAAVGTPAPDGPVLSLAGYAELSGTMAAAVDSAVTEHAATGFAGPPAEVAAAFDRSLDAVRAVLDRPAGAEREPTAVVVGRRMLLTDYLVTRLVEAVVHADDLADALGLDTFPHDRQALAAVTRMLADAFADRVPGGAVELRIPPYAVVQAVPGPKHTRGTPPNVVETDPLTWIRLATGRMPWAAAVADHAVAASGERSDLGEYLPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC19</accession>
    <name>A0A1E7NC19_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290733.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000650.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1750"/>
    <dbReference type="EnsemblBacteria" id="ARF80238">
        <property type="protein sequence ID" value="ARF80238"/>
        <property type="gene ID" value="B6264_16145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38246">
        <property type="protein sequence ID" value="OEV38246"/>
        <property type="gene ID" value="HS99_0022135"/>
    </dbReference>
    <dbReference type="OMA" id="TFHITRN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="10847" checksum="AFBDDA72669749E3" modified="2017-01-18" version="1">MKTITQREFRNNSAAVMDAVEAGETFHITRNGVEVAELRPVSGRRRLTAEELVARHVKLPRVDYQEMRKEAEEYFGPEELVGDEGDDPFERRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC35</accession>
    <name>A0A1E7NC35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290723.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1745"/>
    <dbReference type="EnsemblBacteria" id="ARF80234">
        <property type="protein sequence ID" value="ARF80234"/>
        <property type="gene ID" value="B6264_16120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38250">
        <property type="protein sequence ID" value="OEV38250"/>
        <property type="gene ID" value="HS99_0022160"/>
    </dbReference>
    <dbReference type="OMA" id="LFLLFDC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27011" checksum="74E08D06055B7A52" modified="2017-01-18" version="1">MVAAPALAELREVCQPQAKLQSRNGEHWAGRMYMRAISLRTTRQLVRTRVSPNTLTWVMVVCGVGGGAALLIPGPTGAVLAAVLFQLFLLFDCVDGEVARWKRQFSMAGVYVDRLGAYLADAALMIGAGVRAARGGSELWVSAGLAAALGVVLLKASTDLVDVARARSGQPPANEESTQPRSQGIATARRFASIFKIHRVTNGIEASLVLLAAAAVDAGLHNLDATRWTLAGITVITWGMVVAHLASILSSSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC60</accession>
    <name>A0A1E7NC60_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284090.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4199"/>
    <dbReference type="EnsemblBacteria" id="ARF80202">
        <property type="protein sequence ID" value="ARF80202"/>
        <property type="gene ID" value="B6264_15915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38281">
        <property type="protein sequence ID" value="OEV38281"/>
        <property type="gene ID" value="HS99_0022355"/>
    </dbReference>
    <dbReference type="OMA" id="ETDATIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="44297" checksum="8852B8091E846F71" modified="2017-01-18" version="1">MSQSAQAPAPAKAPTPIQKFGNSVLPGLQKVGRSLQLPIAVLPAAGLLARLGQPDVHEKWHFPAKLVEVFGAAGTAVTGALPLLFCVGIAIGYAKKADGSTALAALVGYLVFKNVLTAFPAHGTVTEALPAGKPQDPGVLGGIVVGLLAAILWQRFHRTKLVDWLGFFNGRRLVPIIMAFVGTGLGVIFGLGWQPIGDAISHVNNGLVGAGAVGAGLFGLINRALIPIGMHQFVNTYAWFQTGDYTDAHGTVVHGDINRFLAGDPTAGQFQAGFYPIMMFALPAAALAIAHCARPERRKAVTGMMISIALTSFVTGVTEPIEFTFLFIAPALYAIHAVLTAVSMALTWALGIHHGFSFSAGLIDYTINFSLAKNPLLIIPIGLAFAAIYYFVFRFAITKFNLKTPGREDDAEIEDITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND94</accession>
    <name>A0A1E7ND94_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282975.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1791"/>
    <dbReference type="EnsemblBacteria" id="ARF77704">
        <property type="protein sequence ID" value="ARF77704"/>
        <property type="gene ID" value="B6264_01105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38670">
        <property type="protein sequence ID" value="OEV38670"/>
        <property type="gene ID" value="HS99_0020690"/>
    </dbReference>
    <dbReference type="OMA" id="MERRHGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13951" checksum="5410E8CA3124BA3F" modified="2017-01-18" version="1">MTEQHVEHPLAAAVKPLLAAVGATPVPLDEAKAEDVVLEWEGTPALAVRLPHLSSALDRLLAEMTRQFDGRPLAELDRWEKQRVVALLEERGAFTVRHGVETVASALGVSRFTVYNYLNRQDGSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND96</accession>
    <name>A0A1E7ND96_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552181.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000704.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1777"/>
    <dbReference type="EnsemblBacteria" id="ARF77690">
        <property type="protein sequence ID" value="ARF77690"/>
        <property type="gene ID" value="B6264_01035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38657">
        <property type="protein sequence ID" value="OEV38657"/>
        <property type="gene ID" value="HS99_0020620"/>
    </dbReference>
    <dbReference type="OMA" id="HTPIHHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="40666" checksum="E5545AB82975CA40" modified="2017-01-18" version="1">MQDIAEQLQAWHASGRSFAVATVVGVSGSAPRDPGAALAVDAAGEAVGSVSGGCVEGAVYELCQAAVESGEPVLERFGYSDEDAFAVGLTCGGILDVFVQPVVPGAAPGMDAGLALIADGTPVALARIIAGPAGMLGATIAVTATGQHGALSVGPSTVGALERSLVAEARAMLDAGRTGRIVLGLDGRPCDEHGQGTVTCFVESYVPAPRMLVFGAIDFAAAVVRIGKFLGYHVTVCDARPVFATTRRFPEADEVVVDWPHRYLDSQLGRIDGRTVLCVLTHDAKFDVPLLERALRLPVGYVGAMGSRRTHRDRQAKLREAGLTDAELARLRSPIGLDLGSRTPEETAVSVAAEIVAHRRGGSCLPLSAGDGPIHHDAAAAAEEPQAARRTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX3</accession>
    <name>A0A1E7NDX3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6536"/>
    <dbReference type="EnsemblBacteria" id="OEV38897">
        <property type="protein sequence ID" value="OEV38897"/>
        <property type="gene ID" value="HS99_0019780"/>
    </dbReference>
    <dbReference type="OMA" id="SWWLPRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15431" checksum="2635A41C50EECF52" modified="2017-01-18" version="1">MLEKPPAPPLDFSWWLPRHHKSAGFARRLLRTFLAEEPGAERFLDDGQLVLGELVANSVLHAKTPPGRLVFIRLSLCPDSLRIEVHDADANQPAAHPATEEAETGRGLWLVSQLAASWGCRPRPGGIGKVMWALLEGGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX6</accession>
    <name>A0A1E7NDX6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Luciferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555472.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6539"/>
    <dbReference type="EnsemblBacteria" id="ARF81308">
        <property type="protein sequence ID" value="ARF81308"/>
        <property type="gene ID" value="B6264_22530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38900">
        <property type="protein sequence ID" value="OEV38900"/>
        <property type="gene ID" value="HS99_0019795"/>
    </dbReference>
    <dbReference type="OMA" id="GWDGFFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="31812" checksum="5792739E45B90510" modified="2017-01-18" version="1">MRFSVNIPNFGDFADPRNVATVAAAAEQAGWDGLFVWDHVLHRQHQGRPFGDPWMLLTAAALATSRIRLGTLLTPVPRYRPQQLARQVATLDHLSGGRVIFAAGLGGPVEDEYRSFGDAAEPRLLAERLDEGLELLRHFWSGEPVNHHGGHYEVRDVTLLPATVQRPGPPVWIGGFWPRRAPMRRAARWDGAVPLFETARHGHVPDVAEVRELVGYVRKHRTADAERPFEFVLGGATPPDAAKAKDVIGPLHDAGATWWDERQIQTGPDLDRLLPVLRRIEAGPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE80</accession>
    <name>A0A1E7NE80_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4379"/>
    <dbReference type="EnsemblBacteria" id="ARF83241">
        <property type="protein sequence ID" value="ARF83241"/>
        <property type="gene ID" value="B6264_30340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39011">
        <property type="protein sequence ID" value="OEV39011"/>
        <property type="gene ID" value="HS99_0018070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13934" checksum="89AD257F8EF1595A" modified="2017-01-18" version="1">MRRGHPADTSHQGATVPKTTTATRTFASLAQRHGRHLAYIARQDSNPTVPADPTSIDTTTLIELVNDAAAFLDRVRHDQDAETLESAARLLTEAHHADQPALLRRAARHLRDSYDMACELGDDHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEH7</accession>
    <name>A0A1E7NEH7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366165.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4108"/>
    <dbReference type="EnsemblBacteria" id="ARF83345">
        <property type="protein sequence ID" value="ARF83345"/>
        <property type="gene ID" value="B6264_30980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39116">
        <property type="protein sequence ID" value="OEV39116"/>
        <property type="gene ID" value="HS99_0018705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="65" mass="7383" checksum="94A21C532FC09ED6" modified="2017-01-18" version="1">MIDMSLLGKDWNPALTIEKFLLALLPFLDEPDVNDPLRPEAAEVYVTSKEDYELKAQETSKPYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI8</accession>
    <name>A0A1E7NEI8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290497.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6543"/>
    <dbReference type="EnsemblBacteria" id="OEV38903">
        <property type="protein sequence ID" value="OEV38903"/>
        <property type="gene ID" value="HS99_0019815"/>
    </dbReference>
    <dbReference type="OMA" id="WGIWVLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="14485" checksum="C3296AE64A5B090D" modified="2017-01-18" version="1">MKEGMQHTQVEPGRRYDVFHTDCPARDMVDHVTSRWGIWVLISLRGGDLRFYELRESIQGVSEKMLSQTLRTLVRDGLVRREVEPTTPPQVTYGLTEFGRDVAEPLTDLFDRITRWLPPRTAAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL4</accession>
    <name>A0A1E7NEL4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4066"/>
    <dbReference type="EnsemblBacteria" id="OEV39151">
        <property type="protein sequence ID" value="OEV39151"/>
        <property type="gene ID" value="HS99_0018470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13910" checksum="38B6B0EB3018E210" modified="2017-01-18" version="1">MAAWQREVLGETEAPFRENDAYAKAGRERYARTPRTQSDFAACLREATDPEVALAARAARAYLDVAFFHPFADGNARAALLTLTHVLAREDVILPEVGPLQTTRYPDDPAGAADLATLIGVLNRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEQ5</accession>
    <name>A0A1E7NEQ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557181.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4107"/>
    <dbReference type="EnsemblBacteria" id="ARF83344">
        <property type="protein sequence ID" value="ARF83344"/>
        <property type="gene ID" value="B6264_30975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39115">
        <property type="protein sequence ID" value="OEV39115"/>
        <property type="gene ID" value="HS99_0018700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14897" checksum="F35D30092B90FE85" modified="2017-01-18" version="1">MMTTKKTTAPCQAHDADSWGNCPVAGLRTVQTRLLALLELYADGPLSMDYRFSPDQTTQRAICLLAALLDVRRRAVGGHACGSRWPAGRRLRQAVNHRTEEEFCPARLAERAAKQARAEAADARRRAARASHGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEU6</accession>
    <name>A0A1E7NEU6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000112_gene4046"/>
    <dbReference type="EnsemblBacteria" id="OEV39155">
        <property type="protein sequence ID" value="OEV39155"/>
        <property type="gene ID" value="HS99_0018770"/>
    </dbReference>
    <dbReference type="OMA" id="SHFKAEC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="76"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="27951" checksum="31F18ED16A8DCE87" modified="2017-01-18" version="1">MTDRIRYFFAASGSTYGSPRITLDLWAEGWQVSENTVAKIMAELGLQGRKPPRRRRSLTRQGRRIAARDLVNRHFDAVAPNVLWVGDMTEIGTGEGKVYLATVIDLFSRRLLGYAMGAHHDAALVGASLTMAAATRSGRVDGVIFHSDLGSEYSSQAYNELCDRLGVVQSMGRVGSALDNAAAESFHSTIKVEYIHQQRFATRAEARLKIATWIADFYNTRRRHSAAGGLPPVEFERIISKVRAEAHQEAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX4</accession>
    <name>A0A1E7NEX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285216.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000620.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3541"/>
    <dbReference type="EnsemblBacteria" id="OEV39224">
        <property type="protein sequence ID" value="OEV39224"/>
        <property type="gene ID" value="HS99_0000390"/>
    </dbReference>
    <dbReference type="OMA" id="DFPRLGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="17947" checksum="2D6A777BAFB61083" modified="2017-01-18" version="1">MTTLDARTTALVLIDLMDRIVARQLAPHTGSEVVTASLKLAEDFRAAGAPVVAVRVERPGVAEQPPGSELTAEVEAAADEVVVKRTIGAFEDTGLHELLQARGVETLVFTGIATNLGVESSARAAADRGYRLVFVEDAMTGLTEAEHRASVDLNFPRLGEVVASADLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEX9</accession>
    <name>A0A1E7NEX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550200.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82457">
        <property type="protein sequence ID" value="ARF82457"/>
        <property type="gene ID" value="B6264_29500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39259">
        <property type="protein sequence ID" value="OEV39259"/>
        <property type="gene ID" value="HS99_0000635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10916" checksum="5C3F581627C5AD45" modified="2017-01-18" version="1">MRVRSAEVNRLPQPPSVPGTQLPVLVRYGHRSWLIPAVLLVAVVVVDALTPSSFASVSWLALVPVVAAAVVRHTGGRRTDDTALLAVRHSPVRLPAEPGRCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS9</accession>
    <name>A0A1E7NFS9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39560">
        <property type="protein sequence ID" value="OEV39560"/>
        <property type="gene ID" value="HS99_0002445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15179" checksum="1C1B72D3685C3618" modified="2017-01-18" version="1">MEDHDPLRTRTGDAQGATSVALEGELDIATAPLLIDAVVRALAARRPRLDLDVAALTFCDAAGVHALLQARRICRVHCAGFRLVGVRPGLGRILVLLRLTDLLTSPAEPVGSGAGAGSPDPLHASSPPSRLPFPARLPLPKESMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG03</accession>
    <name>A0A1E7NG03_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279252.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2780"/>
    <dbReference type="EnsemblBacteria" id="OEV39640">
        <property type="protein sequence ID" value="OEV39640"/>
        <property type="gene ID" value="HS99_0002930"/>
    </dbReference>
    <dbReference type="OMA" id="PIFGTTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="10"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23952" checksum="3597E34D43FCDAB6" modified="2017-01-18" version="1">MNATIDRIRRQVSDLHQELVRYNLVVWTAGNVSARVPGEDLLVIKPSGVPYDELTPANMIVCDLDGKVVEGEHAPSSDTAAHAYVYRHLPEVGGVVHTHSTYSCAWAARGEAVPCVLTAMADEFGAEIPVGPFALIGDDSIGRGIVDTLRGHRSPAVLMQNHGVFTIGKDAEAAVKAAVMCEDVARTVHLSRQLGEPLPIAQADIDSLNHRYQNVYGQPQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG93</accession>
    <name>A0A1E7NG93_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387512.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000984.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2842"/>
    <dbReference type="EnsemblBacteria" id="OEV39692">
        <property type="protein sequence ID" value="OEV39692"/>
        <property type="gene ID" value="HS99_0003240"/>
    </dbReference>
    <dbReference type="OMA" id="FFWRTAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017741">
        <property type="entry name" value="FAD-dependent_OxRdtase_HpnW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03364">
        <property type="entry name" value="HpnW_proposed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="17"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="40877" checksum="B5B217BFE6AF1839" modified="2017-01-18" version="1">MSSSTPPVTSPTTPRSDVVIVGAGIIGLAHAFEALSNGLSVTVLDRDRRPVGASVRNFGHCCISAQDGELLALAQRSRPGWLRAAEASGIWAAEAGTLVVARSATEAAVLEELHAERGGDAVRLRSAAQTAEALGRAAGEDGDLVGGAVLPADLRVDPREAAPGLARWVAEQPRGRILWGTAVTGVESGTVHTTRGPVHGDRILVCVGHDLDHLLPDVAEDHGIQRCRLTMARAAAPEGFRTDSAVLTATSMLRYDAFTARPSAARLREEVLGHSAELLEIGANVMFTRQPDGTLLIGDSHHYDATTPPFVDERTYELLIDAVARVLGVPRLRILERWQGVYASSPRGPLLVRDLAPGVRAISVTSGIGMTLSFGLAAATFDGTLAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGM4</accession>
    <name>A0A1E7NGM4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279159.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2730"/>
    <dbReference type="EnsemblBacteria" id="OEV39850">
        <property type="protein sequence ID" value="OEV39850"/>
        <property type="gene ID" value="HS99_0002680"/>
    </dbReference>
    <dbReference type="OMA" id="YSLGHRV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="237" mass="24874" checksum="38563A4E22AE1652" modified="2017-01-18" version="1">MENTSGVGVLDKITSILGTLEAGPATLAGLVDATGLARPTAHRIAVALEHHRLLGRDVQGRFVLGPRLAELSAAAGEDHLLAAAGSVLTHLRDLTGETAQLYRRQGEVRICVAAAERLFGLRDTVPVGLALPMKVGSAAQVLLAWEEPERLHRGLQGARFTATALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGAQLSRAVVEAAARLTEALNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGN8</accession>
    <name>A0A1E7NGN8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550142.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3519"/>
    <dbReference type="EnsemblBacteria" id="OEV39785">
        <property type="protein sequence ID" value="OEV39785"/>
        <property type="gene ID" value="HS99_0000280"/>
    </dbReference>
    <dbReference type="OMA" id="EICGMQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199210" evidence="1">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="115"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="32875" checksum="0DCFE03F4676BDAA" modified="2017-01-18" version="1">MLAAVCLTAVVAGCAAPAAQPEPSPTGGASAALGAVPLKVPGLARQEEEGSGEADARQADAARAALEAAQRWGLDRPPLKAPPRPATRTALTPVQGVKLKDGRPPVVFRVPIQEKVVFLTIDDGFEKDPEFSRMARELGIPVSAFLSDYLVRDNYGYFRDLHQQGVEINNHTINHRNLKVLDYETQRQEICDQQDQLERQIGVRPRLFRPPYGEYNDDTLRAAASCGVQAVPLWNEEAFPDHMEWRYDDRTLHPGDIILTHFRGISDWKATMPDLLRKVVNDVTAAGFSLGRLDDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGS5</accession>
    <name>A0A1E7NGS5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279511.1">
        <property type="nucleotide sequence ID" value="NZ_JNWR01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2907"/>
    <dbReference type="EnsemblBacteria" id="OEV39872">
        <property type="protein sequence ID" value="OEV39872"/>
        <property type="gene ID" value="HS99_0003555"/>
    </dbReference>
    <dbReference type="OMA" id="WLVWHLT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="18494" checksum="DF75B463FD339FDD" modified="2017-01-18" version="1">MTSSDLLVDAFDRIRDTVADVVDGLTPEQLAYRVHDSANSIAWLVWHLTRVQDDHLADAADREQVWTADGWASRFALPFAASSTGYGHRPAQVAKVTATADLLAGYHEAVHARTVDYVRGLDNRSLARIVDESWQPPVTLGVRLISVIADDLQHVGQAAYVRGLLARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH70</accession>
    <name>A0A1E7NH70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0000720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000137.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3609"/>
    <dbReference type="EnsemblBacteria" id="OEV39803">
        <property type="protein sequence ID" value="OEV39803"/>
        <property type="gene ID" value="HS99_0000720"/>
    </dbReference>
    <dbReference type="OMA" id="PVWISEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199156" evidence="3">
        <location>
            <begin position="28"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="115"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="646" mass="69102" checksum="CB20198989F032D5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2001-03-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q9FAR3</accession>
    <name>Q9FAR3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actinorhodin polyketide synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tcsF</name>
        <name evidence="4" type="ORF">HS99_0013280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2000-02" db="EMBL/GenBank/DDBJ databases">
            <title>Analysis of the chlortetracycline polyketide synthase genes from Streptomyces aureofaciens NRRL3203.</title>
            <authorList>
                <person name="Nakano T."/>
                <person name="Ikeda M."/>
                <person name="Mizukami T."/>
                <person name="Katsumata R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">NRRL3203</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AB039379">
        <property type="protein sequence ID" value="BAB12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549940.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5204"/>
    <dbReference type="EnsemblBacteria" id="ARF80628">
        <property type="protein sequence ID" value="ARF80628"/>
        <property type="gene ID" value="B6264_18500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33524">
        <property type="protein sequence ID" value="OEV33524"/>
        <property type="gene ID" value="HS99_0013280"/>
    </dbReference>
    <dbReference type="OMA" id="EFTELGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAB12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8889" checksum="6A176429D40B55B4" modified="2001-03-01" version="1">MAEFTLDDLIAALKEAAGADEGVAHDDILDVPFADLGYDSLALFNTLNTIERERGITLPDETVVEATTPRMLLDAVNLGLATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>S4S3B5</accession>
    <name>S4S3B5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CtcJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ctcJ</name>
        <name evidence="3" type="ORF">HS99_0013335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Metab. Eng." volume="19" first="69" last="78">
            <title>Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens.</title>
            <authorList>
                <person name="Zhu T."/>
                <person name="Cheng X."/>
                <person name="Liu Y."/>
                <person name="Deng Z."/>
                <person name="You D."/>
            </authorList>
            <dbReference type="PubMed" id="23800859"/>
            <dbReference type="DOI" id="10.1016/j.ymben.2013.06.003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">F3</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HM627755">
        <property type="protein sequence ID" value="AEI98653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5215"/>
    <dbReference type="EnsemblBacteria" id="ARF80637">
        <property type="protein sequence ID" value="ARF80637"/>
        <property type="gene ID" value="B6264_18555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33535">
        <property type="protein sequence ID" value="OEV33535"/>
        <property type="gene ID" value="HS99_0013335"/>
    </dbReference>
    <dbReference type="OMA" id="INIALWE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AEI98653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10575" checksum="7AE9A343067C8BCF" modified="2013-10-16" version="1">MYTFINRFTVTGDVAEFETLVGEISEFMSGRPGFRSHRLYRCATDASVYVETAEWDDAASHRAATGSPEFRARVGKVMSLAKAEPAPFDLLAQHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV63</accession>
    <name>A0A1E7MV63_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6901"/>
    <dbReference type="EnsemblBacteria" id="OEV32316">
        <property type="protein sequence ID" value="OEV32316"/>
        <property type="gene ID" value="HS99_0016555"/>
    </dbReference>
    <dbReference type="OMA" id="NILLHAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="21459" checksum="DCC89BF6334897D1" modified="2017-01-18" version="1">MDEERVACPAAPGTAPEYSTARRARHGGRGGSPPSRPARRADGPAGAAGWPAAGGLWVAVDRDGPVRIVHVAGELDHDSADGLCGALVRPVEDGIERIVLDLGELGFCDSTGLNILLHARLDAEAVGLRLELAGLRPAVARLFAVTGADTVLRIHPDLGAALAAPGRVPAAASDAPSASEPQSEREQWPEPEQPSGEVSSARPGAPPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVM6</accession>
    <name>A0A1E7MVM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557458.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1221"/>
    <dbReference type="EnsemblBacteria" id="OEV32474">
        <property type="protein sequence ID" value="OEV32474"/>
        <property type="gene ID" value="HS99_0017490"/>
    </dbReference>
    <dbReference type="OMA" id="DEAWCVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="489" mass="51299" checksum="84F8D22E367C4036" modified="2017-01-18" version="1">MLDQLAHALRTHHPDRPAVLHHTRTGATRTRIRRGELADLADGYAAALHARRLTHGATLGLALRPGPRALAALIAAHRLGLRVAVLDPTAGPDVLAAHLALAGPGLILADATAQAAAGWAAPLARRADLHLPRLATLGPVATLGPRLPGCAPRLRPATTPVPPRRHDPDADAVIVFTSGTTARPRAVVHTHGGLTAGLRTVTDLVRPQEGTTVLGGTFFVLAPALAAGATVALPARTPTALARQLTHLTPAHAYLTPPRLRTALAAGARLTGTLWTGSAPADAALLRRAKDAGADTAWSVYALTELFPAAAVEESDKSAHTGDGDLVGHPLPGVRTRLADDGELHLTGPAARHRYLGQEPDPWIRTGDRATLTPDGRIVLAGRLKDMVLRRARNIYPGLYEPALHIPGVELALLVGVPDTDGDERLVALVQPDPGTDPRQLRTRLDGPLQRMGAARPDALLFGTVPLAGRSRKPDRAAASAHCARELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT6</accession>
    <name>A0A1E7MVT6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000096">
        <property type="protein sequence ID" value="OEV32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000099_gene7086"/>
    <dbReference type="EnsemblBacteria" id="ARF82598">
        <property type="protein sequence ID" value="ARF82598"/>
        <property type="gene ID" value="B6264_03575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32538">
        <property type="protein sequence ID" value="OEV32538"/>
        <property type="gene ID" value="HS99_0040265"/>
    </dbReference>
    <dbReference type="OMA" id="CEFFALR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="374" mass="40192" checksum="AB1B01E6D36EE8EC" modified="2017-01-18" version="1">MAELTAGQPSEEPGARQPSVGSAEVGSVALRTFEARQNTAQVTTVTDHDTDLAAYGLAYGEFAYGAYDDPDAEYEPDPEYAATLAPDAARQRRERVGPTGRPLPYFPIPAPVAEHGPAQIIAMCNQKGGVGKTTSTINLGAALAEYGRRVLLVDFDPQGALSVGLGVNPMELDVTVYNLLMERGLTADEVLLKTAVPGMDLLPSNIDLSAAEVQLVSEVARESALARALKPLLPDYDYVIIDCQPSLGLLTVNALTAAHSVIVPLECEFFALRGVALLTETIEKVCERLNPELRLDGILATMYDSRTVHSREVLARVVEAFGEHVFHTVIGRTVRFPETTVAGEPITTYATNSVGAAAYRQLAREVLDRCRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW90</accession>
    <name>A0A1E7MW90_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554933.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000213.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3188"/>
    <dbReference type="EnsemblBacteria" id="ARF78267">
        <property type="protein sequence ID" value="ARF78267"/>
        <property type="gene ID" value="B6264_04470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32695">
        <property type="protein sequence ID" value="OEV32695"/>
        <property type="gene ID" value="HS99_0015615"/>
    </dbReference>
    <dbReference type="OMA" id="WHAAGEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="44665" checksum="85F87A3D99A1B478" modified="2017-01-18" version="1">MTDPVHRPEQAAVRGLLRAVGEALDGPVPREWQAAITATPRHRFLPERIWLENDEGGYEPCDLSTDHDRWFEAAYQDTPIVTQINDGQASAAPADAWPSSSASAPSIVVRMLRDLDVRPGMNVLEIGTGTGWNAALLAHRLGSGHVTSIEIDSEVSEQAWAALNAAGLDVDLICGDGSLGWPHRHPYDRIISTCSVRHIPWAWIEQTRPGGIVLTPWDNPMLCWGLLKLTVERDRAQGRFSPHSAFMLMRNHRQDLRIFRDVVQDDHAPDESETVLPPWEVTGKHWEARFALGLRLGDVWTAWEDDPGVDGVAARLWVATTDARSWAAVDHDGRQNKRFTVWQHGPRRLWDEVTAAHHWWQHNNHPTPDRFGLTVTANRQWAWLDRPAQPVRHPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWK5</accession>
    <name>A0A1E7MWK5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278451.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000090.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1990"/>
    <dbReference type="EnsemblBacteria" id="ARF79566">
        <property type="protein sequence ID" value="ARF79566"/>
        <property type="gene ID" value="B6264_12140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32822">
        <property type="protein sequence ID" value="OEV32822"/>
        <property type="gene ID" value="HS99_0039980"/>
    </dbReference>
    <dbReference type="OMA" id="TRAYECD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="47160" checksum="EAAF40F490BD8EFA" modified="2017-01-18" version="1">MSDLTDRLAQGLPAGAVVVDPDVTAAYSHDMAGFCAAGAPAVVVFPETVEQVQHVLRTATELRVPVVPQGARTGLSGAANAVEGCVVLSLVKLNRILEIDPVNRVAVVEPGVVNAELSRAVEEFGLCYPPDPSSWESCTIGGNIGTGAGGLCCVKYGVTSEYVLGLDVVLADGRLLSTGRRTAKGVAGYDLTRLLVGSEGTLGVVVRAVLSLRPAPAPQLALAAEFPSADTAGAAVCAVMEAGLTPSLMELMDAVSVRAVNELGQMGLPESTQALLLVAFDGPDREAGLARVAELCREAGATEVVPAEDQAESDLLLAARRLALPALDRLGTTMIDDVAVPRSRLAEMLNGVAVIAERHALTIGVVSHAGDGNTHPIVIFDGSDRDQTDRAQRAFDEIMALGLELGGTITGEHGVGLLKRDWLARELGPVALDLQRQLKAVFDPLGILNPGKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX73</accession>
    <name>A0A1E7MX73_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5687"/>
    <dbReference type="EnsemblBacteria" id="OEV33014">
        <property type="protein sequence ID" value="OEV33014"/>
        <property type="gene ID" value="HS99_0014165"/>
    </dbReference>
    <dbReference type="OMA" id="CETRYGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="37858" checksum="10148AB6ECB1F408" modified="2017-01-18" version="1">MTADDGPAGVPPLHLPRRTRLLLYGAIALLVGAVVADLVTGPGTTLSPVLAVAPVLAGATTRTARVPLIAGAIAVLAVGLLETTNTDLPTEVHVTALITVLAATLASAANVVLVAARERQLYQVRTVAEAAQRALLRPPAGRIGPLRLAVRYVAAAAEARIGGDLYAVMETRFGVRILLGDVQGHGLPAVETAADVLGVFREAARTEPDLTRVAERMDAALAARSEDGRFTTALLLNVAPDRDTVTIVNCGHPDPLLRRGGRVSDLEPPFPAPPLGLLGLTGSGYPAGRFEPRLGDLLLLHTDGVSEARDAEGRFYPLAERLPCLPAGNPQDLLDALLADVRGWVGEAGLADDAALLALLWEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE3</accession>
    <name>A0A1E7MXE3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkene reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387183.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5606"/>
    <dbReference type="EnsemblBacteria" id="OEV33081">
        <property type="protein sequence ID" value="OEV33081"/>
        <property type="gene ID" value="HS99_0014565"/>
    </dbReference>
    <dbReference type="OMA" id="PNRIWYP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="40984" checksum="A6B3C07759D71288" modified="2017-01-18" version="1">MTTTTESLLSPYRLGEFDLPNRVVMAPMTRYRAAEDGTPLPIVAEYYAQRASAGLIVTEGIWPSREGQSGWRLPGLETAAHVAGWRTVTEAVHAADGRIVAQLMHGGRQGHPLNRLLGDVPAGPSAVPAPGPVHVRDGGKAEAVTPREMTRAEIRRTVADHVTAAHNALAAGFDAVELHGANSYLIHQFLADNTNLRTDEYGPGTLENRLRFPVELVTAVAEAVGPHRLGLRLSPGNPQFGMYEADPAPVYRALLAELDGLGLAYLHLTDNDDYPALAALRPRWSGPLIANVGENRDATDRARGEAVLAAGLADLVSYGRAFIANPDLPERFAAGAPLTPVDETHLYGQTATGFTDYPRLTDQPTPERPTPSERPKAPHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE7</accession>
    <name>A0A1E7MXE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33102">
        <property type="protein sequence ID" value="OEV33102"/>
        <property type="gene ID" value="HS99_0014700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7111" checksum="546D1F7D89C8198F" modified="2017-01-18" version="1">MDTGDLEVLLGDGGGIRGSAAVVHTQVREAGDDGVTGRVQVAGLDVLARAVRREVVPAVADGVSTLPTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXW0</accession>
    <name>A0A1E7MXW0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">HS99_0038945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283777.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4506"/>
    <dbReference type="EnsemblBacteria" id="ARF82881">
        <property type="protein sequence ID" value="ARF82881"/>
        <property type="gene ID" value="B6264_17165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33277">
        <property type="protein sequence ID" value="OEV33277"/>
        <property type="gene ID" value="HS99_0038945"/>
    </dbReference>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="341" mass="36198" checksum="84CEC95A98E5CD23" modified="2017-01-18" version="1">MSFIGRDLAIDLGTANTLVYVRGKGIVLNEPSVVAVNTNTGGILAVGAEAKKMIGRTPGNIVAIRPLKDGVIADFEITERMLRYFILKIHRRRYLARPRVVVCVPSGITGVERRAVIEASSQAGARQVHIIEEPMAAAIGAGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIVQHIKKEYSLLLGERSAEQIKMSIGSAYGLEGEKDEHAEIRGRDLVSGLPKTVVISAAEVRAAIDEPVNSIIDAVKTTLDQCPPELAGDVMDRGIVLTGGGALLRGLDERLRRETGMPIHIAENPLDSVALGSGKCVEEFEALQQVLDASPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY32</accession>
    <name>A0A1E7MY32_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">HS99_0012195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283905.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3394"/>
    <dbReference type="EnsemblBacteria" id="OEV33350">
        <property type="protein sequence ID" value="OEV33350"/>
        <property type="gene ID" value="HS99_0012195"/>
    </dbReference>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="109"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37490" checksum="A07F9ACC0F6637F8" modified="2017-01-18" version="1">MAGEVRQLDDRKLAVLRAIVQDYVGTEEPVGSKALVERHNLGVSPATVRNDMAALEEEGYIHQPHTSAGRIPTDKGYRLFVDKLAEIKPMSSPERRAIRHFLDGAVDLDDVVRRTVRLLAQLTRQVAVVQYPSLTRSTVRHIELVALAPAKVMLVLITNTGRVEQRMIDCPGTVGETVLADLRTRINARAAGQRLPDVPGLLEELPAAFEQTDRPTVSTVLATLFEALAEQNEERIMLAGTANLTRFGHDFPLTIQPVLEALEEQVVLLRLLGETADPAMTVRIGRENAYEGLNSTSVVSVGYGSGDESVAKLGVIGPTRMDYPGTMGAVRAVARYVGQILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY56</accession>
    <name>A0A1E7MY56_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366798.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4015"/>
    <dbReference type="EnsemblBacteria" id="ARF80480">
        <property type="protein sequence ID" value="ARF80480"/>
        <property type="gene ID" value="B6264_17585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33378">
        <property type="protein sequence ID" value="OEV33378"/>
        <property type="gene ID" value="HS99_0012360"/>
    </dbReference>
    <dbReference type="OMA" id="NWIDRVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="42009" checksum="4A13A57A773E87C0" modified="2017-01-18" version="1">MADDSPGAASEVTAPSSRGAVAALMFSQGVGVAGTQVTALALPTLAILLLDAGPLAASLVFALEYGIQGLTGPFAGVLVDRVASRRRLLIAVDVVQLLLVATVPLAHAVGALTLVQLYAVAAVSGALGGVTAIAVPTVVADFVPRDGLVAVNAKLAGARSAGQIAGPGLAAALVQAVGAATAMVADAVSYGLSALAMSLPRLRRDEEPERAAARPGIADSLREGIDVLRDQPLLARLAVAAAALNLGGAGLGGLFVYFAYQVVDLGPGELGLTQAVYSIAAVTAVFTAKRVVRRVGLTRVIPLFGPLAAGALFLIPLASLGAALPVLITYQLVFGFCATVWSVSWVTLQQRLSPPEQLGRVLGLSRSIGQLVVPVGALLGGALAGAVGTTGALAVFASIALAGTLAVAATRSQPALPGAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA0</accession>
    <name>A0A1E7MYA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553427.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3972"/>
    <dbReference type="EnsemblBacteria" id="ARF80516">
        <property type="protein sequence ID" value="ARF80516"/>
        <property type="gene ID" value="B6264_17815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33412">
        <property type="protein sequence ID" value="OEV33412"/>
        <property type="gene ID" value="HS99_0012590"/>
    </dbReference>
    <dbReference type="OMA" id="IENWPVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="280" mass="29639" checksum="9B6AA1B610ACFF2D" modified="2017-01-18" version="1">MKSLRMIENWPVPHAAAAVVRGSDGAVLGTHGPQQHLFPLASVTKLLTSYAALVALEEGVFELDDPAGPPGSTVRHLLAHTSGLGFDENRVFAEPGNRRLYSNAGFDVLALTLAEAAGIAFHQYAAEAVFEPLGMRDTVINTASKSPAGAGGLSTVADLARFAAELQSPKLLDPSTVRRATREVAFPGTSGVLPGYGHRRPNDWGLGFEIRDGKSQHWTGTANSPETFGHFGQSGTFLWVDPQAGVACVALTDQDFGPWSVDAWPQLSDAVLAELAQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI1</accession>
    <name>A0A1E7MYI1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0013000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288669.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6625"/>
    <dbReference type="EnsemblBacteria" id="ARF80584">
        <property type="protein sequence ID" value="ARF80584"/>
        <property type="gene ID" value="B6264_18220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33479">
        <property type="protein sequence ID" value="OEV33479"/>
        <property type="gene ID" value="HS99_0013000"/>
    </dbReference>
    <dbReference type="OMA" id="LPDKTMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20036" checksum="E1C44C9801C8DCE3" modified="2017-01-18" version="1">MNPTIAALTFGIIFLAELPDKTALASLVLGTKYRAGYVFAGVAAAMLVQVVLALVAGHLLSLLPHRWVEGVTGTLFLVGAAMLLFHGGEDEDEHAAREPSSNSFWKVAGTSFAVVAVAEFGDLTQIMTANLAAKYADPLAVGLGSWLALCAVGGIAIVGGQKLLKYVPMKLIIRVAAAIMVVLAGVSIFGAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYM5</accession>
    <name>A0A1E7MYM5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385711.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5223"/>
    <dbReference type="EnsemblBacteria" id="ARF80645">
        <property type="protein sequence ID" value="ARF80645"/>
        <property type="gene ID" value="B6264_18595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33542">
        <property type="protein sequence ID" value="OEV33542"/>
        <property type="gene ID" value="HS99_0013375"/>
    </dbReference>
    <dbReference type="OMA" id="WFHGRLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="30451" checksum="DBCF9A66CE2F034E" modified="2017-01-18" version="1">MVKFNILGPLEVLDKGIPCTPSALKVRWTLAVLLMNANRIVDLGLIIEEIWGSSPPRTVVTTAQTYIYQLRKLCRPLGREVILTKAPGYVLLLGEEELDAQEFERLHHEGDRLLAAGHPEAAAQRLRQALDLWRGTALADIPVGAPLAGHVAVLEEMRLRALEHRILADRQLGRHRELIPELRLLTLHQPMNEWYHEQLMLALDAAGRRSEALHVYRVLYRRLDEDLGIAPSRPLQELHNDLLSGTSPTRQEFQALAARAMEQGLRARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYP1</accession>
    <name>A0A1E7MYP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5222"/>
    <dbReference type="EnsemblBacteria" id="ARF80644">
        <property type="protein sequence ID" value="ARF80644"/>
        <property type="gene ID" value="B6264_18590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33541">
        <property type="protein sequence ID" value="OEV33541"/>
        <property type="gene ID" value="HS99_0013370"/>
    </dbReference>
    <dbReference type="OMA" id="TPASWPI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="660" mass="71604" checksum="79F052266F4F6D28" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ23</accession>
    <name>A0A1E7MZ23_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0038305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4302"/>
    <dbReference type="EnsemblBacteria" id="OEV33700">
        <property type="protein sequence ID" value="OEV33700"/>
        <property type="gene ID" value="HS99_0038305"/>
    </dbReference>
    <dbReference type="OMA" id="RITWIAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="42664" checksum="95E1A288198DA32D" modified="2017-01-18" version="1">MKLQQLVLVEVAVALVAVGWTISRPVAAGFGAVSLVLLVLALVPLRGRTIPELLQVRSALKSRRRQAKSLLPPPGTDPALAPALELEPGLRTCTHATEADFGGRPVRRETGMVGDGTFLSSVLLVQAKDQPLRPVRTALPLPLDVICSALTVDDITLESVQLVQHTQPAPAPHLPEQSLAARAYRELPDGTSTPGLRLTWVALKLDPERAATAVRARGGGEEGARKALQRVTDQLAGRLNSAGFNATVLDERELIAALAIATCANPIAVAGRQGTGSGGGTTRRTQEGNRFWRIDDRWHSTYWISRWPQLSRPGGAPGRIGAPDLVNLITGSPALASTFSLTAGHGTGGSVTVSGHLRVTGRSESEVGQVGRQVEARAQSTGLGLVRLDLEQAPGMLATLPLGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ24</accession>
    <name>A0A1E7MZ24_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan 2,3-dioxygenase</fullName>
            <shortName evidence="1">TDO</shortName>
            <ecNumber evidence="1">1.13.11.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptamin 2,3-dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan oxygenase</fullName>
            <shortName evidence="1">TO</shortName>
            <shortName evidence="1">TRPO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophan pyrrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Tryptophanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynA</name>
        <name evidence="2" type="ORF">HS99_0012950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="1.13.11.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="1">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.11" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288690.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6615"/>
    <dbReference type="EnsemblBacteria" id="ARF80576">
        <property type="protein sequence ID" value="ARF80576"/>
        <property type="gene ID" value="B6264_18170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33473">
        <property type="protein sequence ID" value="OEV33473"/>
        <property type="gene ID" value="HS99_0012950"/>
    </dbReference>
    <dbReference type="OMA" id="WRWRNDH"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004833">
        <property type="term" value="F:tryptophan 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01972">
        <property type="entry name" value="T23O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004981">
        <property type="entry name" value="Trp_2_3_dOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10138">
        <property type="entry name" value="PTHR10138"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03301">
        <property type="entry name" value="Trp_dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="SSF140959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="30978" checksum="DC7ABEFDACB7E9DD" modified="2017-01-18" version="1">MGHDTVETPNLSFGRGGQPGRGTPYAQYVRLEQLHSLQHPRSKEPAELSFIVTTQVMELLFDLLRHEWTIAGQSLREDDLTAALAALRRGTHVQDVLVESWDLLATMTPQEFNSFRPLFGEASGFQSSAFLHLEFLIGNKNAALLNMYDGMPEVRAELTEALRSPGLYDEVLGLLARRGLAVHAEPSEQRYRPTEEVAAAWRRVYTEPEFAALQPLGEALLDVAERVTRWRQRHLSSVKRTMGAKPGSGGSSGLTWLRKAAEQDVFPELWTIRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZL9</accession>
    <name>A0A1E7MZL9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nickel-type superoxide dismutase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6381"/>
    <dbReference type="EnsemblBacteria" id="ARF82679">
        <property type="protein sequence ID" value="ARF82679"/>
        <property type="gene ID" value="B6264_07290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33889">
        <property type="protein sequence ID" value="OEV33889"/>
        <property type="gene ID" value="HS99_0037355"/>
    </dbReference>
    <dbReference type="OMA" id="WWVLGDN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014124">
        <property type="entry name" value="Pept_S26A_Sod_Ni_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02754">
        <property type="entry name" value="sod_Ni_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="13572" checksum="68452C6C7F862C37" modified="2017-01-18" version="1">MVPTLREGDQLLVRYGAPIRPGAVVLFRHPFQQDLLVVKRAAERRPKGWWVLSDNRPVDSDSRSYGPVPDELVLGRVLLRLRPSPAWLAPGRGLERLLLGPRLSRLPGLARRLGVWVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZX1</accession>
    <name>A0A1E7MZX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280256.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2204"/>
    <dbReference type="EnsemblBacteria" id="ARF77833">
        <property type="protein sequence ID" value="ARF77833"/>
        <property type="gene ID" value="B6264_01835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33975">
        <property type="protein sequence ID" value="OEV33975"/>
        <property type="gene ID" value="HS99_0010990"/>
    </dbReference>
    <dbReference type="OMA" id="LFNPMTK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="566" mass="63481" checksum="347D3590B97227A3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N012</accession>
    <name>A0A1E7N012_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Urea amidohydrolase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ureC</name>
        <name evidence="12" type="ORF">HS99_0011280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 10">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="5 7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Carboxylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2267"/>
    <dbReference type="EnsemblBacteria" id="ARF77878">
        <property type="protein sequence ID" value="ARF77878"/>
        <property type="gene ID" value="B6264_02130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34022">
        <property type="protein sequence ID" value="OEV34022"/>
        <property type="gene ID" value="HS99_0011280"/>
    </dbReference>
    <dbReference type="OMA" id="CHHLSHD"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 7" id="KW-0533">Nickel</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5 8 9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="5 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5 6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="574" mass="60940" checksum="A4BD93719AF5F5EB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0B2</accession>
    <name>A0A1E7N0B2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="15" type="ORF">HS99_0011820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386680.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000459.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3701"/>
    <dbReference type="EnsemblBacteria" id="OEV34115">
        <property type="protein sequence ID" value="OEV34115"/>
        <property type="gene ID" value="HS99_0011820"/>
    </dbReference>
    <dbReference type="OMA" id="TNPGETF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="723" mass="77112" checksum="C042AC4D0C38C014" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0L2</accession>
    <name>A0A1E7N0L2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285686.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6063"/>
    <dbReference type="EnsemblBacteria" id="ARF78153">
        <property type="protein sequence ID" value="ARF78153"/>
        <property type="gene ID" value="B6264_03800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34237">
        <property type="protein sequence ID" value="OEV34237"/>
        <property type="gene ID" value="HS99_0036900"/>
    </dbReference>
    <dbReference type="OMA" id="TCLWYIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="225"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="49363" checksum="0DE56438311C138F" modified="2017-01-18" version="1">MTAMQPHELVELALGLSRTDGCVVIADEESTANLRWAGNALTTNGVTRGRRLTVIATVAGAEGTASGVVSREAVTAEDVEGLVRAAEEAARAAGPAEDAQPLVADRPQSPDFTAPPAETSIEVFDAFGPALGEAFARAAARGELLYGFARHEVTTSYLGSSTGLRLRHDQPTGMVEINGKTADLTGSAWVGAATRDFTDIDVPALHAELTKRLGWGARKVDLPAGRYETLLPPSAVADLMIYLHWSSGGRDAHEGRTVFSKPGGGTRLGDKLAGLPLTLRADPDEPGLEAAPFVLAHSSGGDVSVFDNGAPITATDWIRDGVLTDLITSRHAAGLTGLPLRPAVDNLVLETADQESAPTLDEMIARTERGLLLTCLWYIREVDPATLLLTGLTRDGVYLVENGEVVGAVNNFRFNESPVDLLGRITEAGRTERCLPREWSDYFTRTAMPPVRVADFNMSSVSQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U6</accession>
    <name>A0A1E7N0U6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2351"/>
    <dbReference type="EnsemblBacteria" id="ARF77953">
        <property type="protein sequence ID" value="ARF77953"/>
        <property type="gene ID" value="B6264_02555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34093">
        <property type="protein sequence ID" value="OEV34093"/>
        <property type="gene ID" value="HS99_0011700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="21584" checksum="36F3D85AACF1A86B" modified="2017-01-18" version="1">MKLGVVLVGLVCGVSSCASLPGGGGPTAAGGGAATVTARPAFPENIKKLVLKFATENGTAPAGGRFTEYDGAHGPELIWVSERTGDLCVASETVTAGMCQTAKRTAEAPVPGVDVFEDSGLTDHHGESSWAIRLVASGEAVDHLSCQGKDFPVLKVYSADLAGALRTVYTVAIPRNLQGEYKVAVRRGSESAEERLDLNMDKVGPPAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Y6</accession>
    <name>A0A1E7N0Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6401"/>
    <dbReference type="EnsemblBacteria" id="OEV34346">
        <property type="protein sequence ID" value="OEV34346"/>
        <property type="gene ID" value="HS99_0036345"/>
    </dbReference>
    <dbReference type="OMA" id="EMAREVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="17629" checksum="B45F16D5A5911FE2" modified="2017-01-18" version="1">MPLGDTGAVTDEEALVAVEREVGLMFRRGRARVAELSRRVHPELDGMAYSMLGYIEQAGRVRVTDVGVHFAVGKGTVSRQIRALEELGLVAREADPLDRRAALVSLTDDGRRRFESARDVRMRRVREVMGGWSREDVDRFADLLHRFNEVLGEPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N139</accession>
    <name>A0A1E7N139_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxyglutarate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557808.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000776.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7198"/>
    <dbReference type="EnsemblBacteria" id="ARF79217">
        <property type="protein sequence ID" value="ARF79217"/>
        <property type="gene ID" value="B6264_10070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34396">
        <property type="protein sequence ID" value="OEV34396"/>
        <property type="gene ID" value="HS99_0035890"/>
    </dbReference>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="411" mass="44043" checksum="FFB32DC4115446A1" modified="2017-01-18" version="1">MADEFDVVVVGGGIVGLATAYALTRARTGLRIAVLEKENGFAAHQTGRNSGVIHSGVYYRPGSYKARFAVAGAAELVGFCREHGIPHEVTGKLIVATDDAELPRLAVLAERGRANGIPVTELDRAGIARYEPEVAGRAGLHVGTTGICDFPAVATTYARLAREAGAELRPGTEVRTLVRRRDRVTVGTAAGELRCRVLVNCAGLHSDRIARLAGDDPGVRIVPFRGEYYELVEQRRALVRGLVYPVPDPAFPFLGVHLTRGIHGDVHVGPNAVPALAREGYAWHTVRPRDLAGTLAFPGTWRILRRHWRYEVGELHRSLSKRAFTTAVQRLLPAVTAADLVPAPAGVRAQAVARDGSLLDDFAFAGFDPEDRHSPRRAVHVLNAPSPAATASLPIGREVARRALAALEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N151</accession>
    <name>A0A1E7N151_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">HS99_0036015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289785.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1415"/>
    <dbReference type="EnsemblBacteria" id="ARF79235">
        <property type="protein sequence ID" value="ARF79235"/>
        <property type="gene ID" value="B6264_10195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34417">
        <property type="protein sequence ID" value="OEV34417"/>
        <property type="gene ID" value="HS99_0036015"/>
    </dbReference>
    <dbReference type="OMA" id="WEFLATG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="32170" checksum="DA49CB745C8EDBEE" modified="2017-01-18" version="1">MSTLTYPEAIGVGLLQGVTELFPVSSLGHSILLPAVIGGKIQQDLDMTADGSSYLAALVALHLATALALVVFFWRDWVRVVSGLFGSIRHRRVQTRDEKLAWLLIISTIPVGVAGLVLEKALRHALGKPVPAAVFLALNGLVLLGAERLKRGGSGRRRAGHAAPVDEPGLDPAVASDVRLTRLGYGRGAWIGAAQILALFPGISRSGVTMSAGILRGLHHEDAARFSFLLATPVILAASVLKVPELFKPENSGVLGPVAAGSLAAFVAGYVSVRFLTRYFETRSLTPFAVYCFLAGVGSAVYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1E8</accession>
    <name>A0A1E7N1E8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550778.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2568"/>
    <dbReference type="EnsemblBacteria" id="OEV34518">
        <property type="protein sequence ID" value="OEV34518"/>
        <property type="gene ID" value="HS99_0035570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="16319" checksum="BBE5545D12D60EC8" modified="2017-01-18" version="1">MYFTVYLLLLVPVAVAAVAPRASRHLAPAAGVRVLTCLAATAAAATVWGLTALSLAGLANLPPVRAHLHSEPRVLAAADPVPWGIGATAGALLAVLAVRVLVTTHGMARQRATVAAVRRLPAAGHLVVLADDRADASALGPVLYTAPDRERTLPAAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1T4</accession>
    <name>A0A1E7N1T4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554701.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4249"/>
    <dbReference type="EnsemblBacteria" id="ARF81988">
        <property type="protein sequence ID" value="ARF81988"/>
        <property type="gene ID" value="B6264_26675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34647">
        <property type="protein sequence ID" value="OEV34647"/>
        <property type="gene ID" value="HS99_0009115"/>
    </dbReference>
    <dbReference type="OMA" id="ESAFAKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="484" mass="53028" checksum="D97A29E086B2F1D3" modified="2017-01-18" version="1">MEHDLVVFLPGILGSRLTRDGKDVWHQSWQAVLQLRHPSKAVEAFKLPPGIGDDEPEPNSPWAVQADELVKGPDAMPGLLASYGYPEVRSLLERAASHDPRGGLHPDQYAVFTYDWRLSNRLNARRLKTWVERELAQWRERAPRFHPKAHDDEPKVVFICHSMGGLIARYYLEYLHGRDLARSLVTIGTPHRGAAKAIRFLTGNGIGPSEDQGWPKRKAAQLASRVNPALADIARSFPSVAQLLPVYAAALVDGGTRWRPLTEVPVGNLPTELVNDAFAFHEEFAGAWERNRATEAAPPYKVHCLGGRAHPTVHGVVVRRDGTLEFPTQLDNSQLWIGDGTVPEESAFAKWALDDISDAVWGGERHTTLAGAESFAHQLDAIRRAKPRRDLLAGEEGFSLVVPDFAVAGEPFEITVSGIGTSGRTVRARLTNNRQPGEAPVTLAPDGIGGLVGEVTGAAGTWILEVEAERPHMVCRDVVTIVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U3</accession>
    <name>A0A1E7N1U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554689.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4242"/>
    <dbReference type="EnsemblBacteria" id="ARF81980">
        <property type="protein sequence ID" value="ARF81980"/>
        <property type="gene ID" value="B6264_26625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34654">
        <property type="protein sequence ID" value="OEV34654"/>
        <property type="gene ID" value="HS99_0009155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15214" checksum="4E21D1D322508527" modified="2017-01-18" version="1">MAPVDQPPGDPCGSTHLGEGALGSLGSLSSLSSLPEVVLAKHTETGRLAALALQWWNEGDREGTLEAIGQVVPAAEAAAAALNTLVELDEAAACTAAEEERRRRENIAANWWGRAGPVTLGVLRARSRSRRLAAGVSVTHEALSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N279</accession>
    <name>A0A1E7N279_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shy6-polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000163.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3245"/>
    <dbReference type="EnsemblBacteria" id="ARF81849">
        <property type="protein sequence ID" value="ARF81849"/>
        <property type="gene ID" value="B6264_25800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34789">
        <property type="protein sequence ID" value="OEV34789"/>
        <property type="gene ID" value="HS99_0009945"/>
    </dbReference>
    <dbReference type="OMA" id="CIRWTGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20466" checksum="2A096B12ADC7F48A" modified="2017-01-18" version="1">MRAPAAATTTALTLALLLTASTAASALTTDQTPTAAAAHRTDVQIDEHAPVITRADILIHAPLHTVWNIQTDVEKWPAWQPNVETVVKDTPGQLRPGSRFRWSTEGLDITSTVRQVDHGRRLAWGGPAQGITAVHVWTFTPTREGVLVHTEESWTGEPVTANQAALQAALDNSLHNWVTNLKHEAETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F8</accession>
    <name>A0A1E7N2F8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0009275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4214"/>
    <dbReference type="EnsemblBacteria" id="OEV34878">
        <property type="protein sequence ID" value="OEV34878"/>
        <property type="gene ID" value="HS99_0009275"/>
    </dbReference>
    <dbReference type="OMA" id="CPTANCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="4">
        <location>
            <begin position="2"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="413" mass="43639" checksum="86CC6D811F2E0C67" modified="2017-01-18" version="1">MFTVGEVWDVAANGRSCLKHHGVYYGSVDLPDAAFAERLPDLPGIFSKHYTNAHRYGLVSLVEACADAQLSIRGGDLSDAAVLVGRGGIDANVASYLEVLHADARTTAPHEAMELFVRAQQGLTPSDVALVQGALMRTTGPCFTVSCGCASSAVQIGNARRMIADGDIDLAVVTGVDVFGVDVIQNVQRLLHGAQRAYDSIRVDGMPELLPAFDRVMRPYDRRADCVNHGEGSVTLVLESRSRAEQRGAYTYGQVLSHGMTRDGLSNPLASDENGASLVAAVRKCLGDRWDVGQIPYIHGGSDGDVVVTAFEANAAKQLYGDGVADLLMTSQEACFGHNGAPAGALGVALTLLMLEQGEVCPTANCEEPADNVCFDPVPGVHTRLIEFDYALTLNYQIGGVKSAILLGSSDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G2</accession>
    <name>A0A1E7N2G2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0010410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557716.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000838.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7589"/>
    <dbReference type="EnsemblBacteria" id="ARF81772">
        <property type="protein sequence ID" value="ARF81772"/>
        <property type="gene ID" value="B6264_25310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34866">
        <property type="protein sequence ID" value="OEV34866"/>
        <property type="gene ID" value="HS99_0010410"/>
    </dbReference>
    <dbReference type="OMA" id="DWSGIYS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017535">
        <property type="entry name" value="Asparagine_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03104">
        <property type="entry name" value="trio_amidotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="594" mass="64850" checksum="1DF1EF354AA1E79F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Y8</accession>
    <name>A0A1E7N2Y8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4741"/>
    <dbReference type="EnsemblBacteria" id="OEV35069">
        <property type="protein sequence ID" value="OEV35069"/>
        <property type="gene ID" value="HS99_0034585"/>
    </dbReference>
    <dbReference type="OMA" id="AGVWVHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="266"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="43573" checksum="43FCD517D908710E" modified="2017-01-18" version="1">MDRDKLYAARLQAVRARPYLATALFALHLVESRQTPTMSVDRYWRCYASPAFVDRTPVEDLASIWVHEVSHLLRDHHGRSDRLARDLGLKGPADRLRMNIAADCEINDDAFGDGLVKPAGALTPEFLDLPDGELMEDYFRGFSFDLRKPGLAWLDCGSGADGVDRDWELGPDGAHGLTAQERDAVRFRVAEAIRGRPGNAPAGWRRWAEEVFHPPQPWRQLLGAAMRSAVSGPGAGGDYSYGRPARRSVGLPGVVLPSLRRRPPRVSVVIDTSGSVSDRELGSALLEVAAIGQAAGGRHDQVTVLSCDAAAQAVGPLCRAAGIPLVGGGGTDLRTGFAAALRTRPRPDVVVVLTDGQTPWPAVAPSCRTVVGLFRRPSRYNENRGEYRPDAPPDWARVVTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N345</accession>
    <name>A0A1E7N345_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="1">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mca</name>
        <name evidence="2" type="ORF">HS99_0034230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385489.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene378"/>
    <dbReference type="EnsemblBacteria" id="ARF82701">
        <property type="protein sequence ID" value="ARF82701"/>
        <property type="gene ID" value="B6264_08320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35129">
        <property type="protein sequence ID" value="OEV35129"/>
        <property type="gene ID" value="HS99_0034230"/>
    </dbReference>
    <dbReference type="OMA" id="PLKLYYN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="33692" checksum="BC87C92DAF20B0D6" modified="2017-01-18" version="1">MTEQLRLMAVHAHPDDESSKGAATMAMYVEQGVDVLVATCTGGERGSVLNPKLQGDPYIEENIHEVRRKEMDEARAILGVKQAWLGFVDSGLPEGDPLPPLPEGCFALEDVKQAAEPLVRLIREFKPQVITTYDENGGYPHPDHIMTHKITMLAFDAAGDPDAYPEAGEPWQPLKLYYNHGFPMGRIRALHQYLTEHGHDSPYGEWIAGWEKSGREERAITTRVRCGDWFETRDRALIAHATQIDPDGPWFRVPLEVQREVWPTEDYELARTLIDVDLPEDDLFAGLRTPTLAAEAAARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3A5</accession>
    <name>A0A1E7N3A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829947.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000337.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4450"/>
    <dbReference type="EnsemblBacteria" id="ARF78446">
        <property type="protein sequence ID" value="ARF78446"/>
        <property type="gene ID" value="B6264_05505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35152">
        <property type="protein sequence ID" value="OEV35152"/>
        <property type="gene ID" value="HS99_0033750"/>
    </dbReference>
    <dbReference type="OMA" id="WAWTTRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031306">
        <property type="entry name" value="CcdC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07301">
        <property type="entry name" value="DUF1453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="17363" checksum="A8E6DFEB23431948" modified="2017-01-18" version="1">MTAVVNLLVTAAVVVLVVQRQMRVQRLDTERRFWLLPLILGVLALRDPQIIDHHHAALSATLLVAGLLTVLAMGTVWGWTVRIWRAADGKVLVKGTKATLAAWGGMLAIRIGLYAIGSALGVHQAGSSLMLGMAVLLLVRSLVVNWRARTLEPAQATAVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3F3</accession>
    <name>A0A1E7N3F3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386984.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000602.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1370"/>
    <dbReference type="EnsemblBacteria" id="ARF79277">
        <property type="protein sequence ID" value="ARF79277"/>
        <property type="gene ID" value="B6264_10420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35216">
        <property type="protein sequence ID" value="OEV35216"/>
        <property type="gene ID" value="HS99_0033390"/>
    </dbReference>
    <dbReference type="OMA" id="NFGAQEW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16885" checksum="68D59828E4A72508" modified="2017-01-18" version="1">MTDSVGGSPADRAVTDGRYRIRNVGSGLLLEVAEASRRSGARIRLGTDDGSDAQLWQLVAVHPGGALFHVENAGSGKRLDVTGASPEDGVPIQQWSANAFGAQEWLLEAHVDAPETYTVTSFISGKPLTAPEAPDGVVQQWEDVDSPTQWWRFERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3N2</accession>
    <name>A0A1E7N3N2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0033085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282815.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5310"/>
    <dbReference type="EnsemblBacteria" id="ARF80721">
        <property type="protein sequence ID" value="ARF80721"/>
        <property type="gene ID" value="B6264_19025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35296">
        <property type="protein sequence ID" value="OEV35296"/>
        <property type="gene ID" value="HS99_0033085"/>
    </dbReference>
    <dbReference type="OMA" id="APNIDWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="313" mass="32684" checksum="29F01E4B34502B29" modified="2017-01-18" version="1">MALTIGVDVGGTKIAAGVVDDAGAILARTRVPTPADPQWAVDAIAQAVRELKEQHPDVTAVGVGAPGFVDSNRSTVIFAPNIDWENEPLRGRIEELTGLSTVVENDANCAAWAEFRFGAAADHQDMVLITVGTGIGGGIVLDGRLHRGRFGVAGEIGHLNMVPDGLQCGCGGKGCWEQYGSGRALRRYGRERAAADPVRGRRMLELNDGVAETIRGIHITEAAEDGDPLALECYAELSDWLGRGMADLAALFDPGVFVLGGGVSDSGRLLLDPVAKAFEHYLTGGVHRPRAEVVLASMGSAAGIVGAADLART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Q1</accession>
    <name>A0A1E7N3Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malonic semialdehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286677.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78885">
        <property type="protein sequence ID" value="ARF78885"/>
        <property type="gene ID" value="B6264_08115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35083">
        <property type="protein sequence ID" value="OEV35083"/>
        <property type="gene ID" value="HS99_0034020"/>
    </dbReference>
    <dbReference type="OMA" id="LMVVNIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21830" checksum="84089383CD52ED8D" modified="2017-01-18" version="1">MTTDALVLDAAAQDLLFREARTANTFTDEPVTEEQVQAIYDLVKYGPTAFNQQPLRVVLVRSAEGRERLVQHLADGNKAKTAAAPLVAILAADNEFHEELPTQFPHFPQAKDVFFAERAVREQSAKLNGALQAAYFIIGVRAAGLAAGPMTGYDAEGINKEFFGDGEHSVLAVVNIGKPGEDAWFPRSPRLEYDQVVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3R2</accession>
    <name>A0A1E7N3R2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ORF">HS99_0032905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387755.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5274"/>
    <dbReference type="EnsemblBacteria" id="OEV35326">
        <property type="protein sequence ID" value="OEV35326"/>
        <property type="gene ID" value="HS99_0032905"/>
    </dbReference>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00569">
        <property type="entry name" value="NadA_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023515">
        <property type="entry name" value="Quinolinate_synth_A_type3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="390" mass="42531" checksum="D5E278205D0A5E5A" modified="2017-01-18" version="1">MTETYGVDPAPTPLALLLLGREADPNSERGVECPGDLPPASDPDLVERARAAKAALGDRVFILGHHYQRDEVIEFADVTGDSFKLARDAAARPEAEYIVFCGVHFMAESADILTSERQQVVLPDLAAGCSMADMATAEQVAECWDVLTDAGIADVTVPVSYMNSSADIKAFTGKHGGTICTSSNAQRALEWAFEQGQKVLFLPDQHLGRNTAVRDMGFSLDDCVLYNPHKPNGGLTAEQLRDAKMILWRGHCSVHGRFSLDSVNDVRERIPGVTVLVHPECKHEVVSAADMVGSTEYIIKALDAAEPGSKWAIGTELNLVRRLAKAHPDKEIVFLDRTVCFCSTMNRIDLPHLVWALESLVEGRVPNVITVDPETEKYAKAALDRMLALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4F0</accession>
    <name>A0A1E7N4F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280375.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000393.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5361"/>
    <dbReference type="EnsemblBacteria" id="ARF80763">
        <property type="protein sequence ID" value="ARF80763"/>
        <property type="gene ID" value="B6264_19280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35571">
        <property type="protein sequence ID" value="OEV35571"/>
        <property type="gene ID" value="HS99_0006515"/>
    </dbReference>
    <dbReference type="OMA" id="PHVEMRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16342" checksum="114DC9C56BE645EA" modified="2017-01-18" version="1">MTVSVRVAEGEADLEQVRAVRREVFVVEQNVPEELEYDEYDATSVHVLAVGADGAALGTGRLIFGEEALKLTGGVEGRVLLGRLAVLAAARGTGLGVELVRAIEAAGRERGGVEVELHAQVRALGFYERLGYVAEGPVYDDAGIPHRTMTRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V9</accession>
    <name>A0A1E7N4V9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate/glutamate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281581.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene832"/>
    <dbReference type="EnsemblBacteria" id="ARF80929">
        <property type="protein sequence ID" value="ARF80929"/>
        <property type="gene ID" value="B6264_20250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35726">
        <property type="protein sequence ID" value="OEV35726"/>
        <property type="gene ID" value="HS99_0007480"/>
    </dbReference>
    <dbReference type="OMA" id="TNTMHLI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="PTHR21198:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24468" checksum="8192C7896F3348BB" modified="2017-01-18" version="1">MKTLGLIGGMSWESTAEYYRTLNELTRARLGGLHSARLVLHSVDFADIEQLQAAGRWEEAGAVLADAARSLEAAGAELLLICTNTMHKVADQVAAAVTVPLLHLADATADAVRAAGLRRIGLLGTAFTMEQDFYRGRLASGGLDVLVPDAESRALVHRVIYEELCVGVVREEARTAYRQVIQELVAAGAEGIVLGCTEIELLVGPGDSPVPVFPTARLHAEAAVSAALAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X2</accession>
    <name>A0A1E7N4X2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551068.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene837"/>
    <dbReference type="EnsemblBacteria" id="ARF80924">
        <property type="protein sequence ID" value="ARF80924"/>
        <property type="gene ID" value="B6264_20225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35722">
        <property type="protein sequence ID" value="OEV35722"/>
        <property type="gene ID" value="HS99_0007455"/>
    </dbReference>
    <dbReference type="OMA" id="RHALYEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02198">
        <property type="entry name" value="YjgH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038743">
        <property type="entry name" value="YjgH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="15214" checksum="F1237DFD6F2366D2" modified="2017-01-18" version="1">MTAHTVEVPEDNAVFGQTTSAFASFGYSAAVRAHGLLFIAGTIGRRADGTIPDTIEEQTEIALRKIEEILRLENLDTSALVDVTSYHVDIRRHLPGFIEAKKRLVRAPYPTWTIIGVSGLASPGLLVEIRATAAYPDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Z9</accession>
    <name>A0A1E7N4Z9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene783"/>
    <dbReference type="EnsemblBacteria" id="OEV35759">
        <property type="protein sequence ID" value="OEV35759"/>
        <property type="gene ID" value="HS99_0007725"/>
    </dbReference>
    <dbReference type="OMA" id="DRWGHLW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="35264" checksum="78FE60150C080C3A" modified="2017-01-18" version="1">MRIDEGRVRALAGWTAVAATGPYLTLKALWLTGHPVGSGDPGAMDELWLVNLLTVGMDAIAAALALAFVRPWGRRAPAGLVLFPMWVATGLLGTILLALPLYLLSSLLLGPERNTGQEPGGGLGGWVFPVVYGGFAVQGLALITAFVLYARHRWAALLRAGTGDLPRSPTLAVQRSLACVAALLGLGTAVARAYWAAGGTAGLPAALAQDRSRGVAVMDAVTAVMAVAAPAGLLVLVFRLRPLRPLRVPLLVVWTAAGSLFGWGCWQLVAFGATAAGTTGPLALVQAAQVLTAVLVLAAGAVALVERAAAARGAVVESPGWTRGAAGFGGRERRCSGGGPDCAGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A2</accession>
    <name>A0A1E7N5A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286172.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000624.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7249"/>
    <dbReference type="EnsemblBacteria" id="ARF81084">
        <property type="protein sequence ID" value="ARF81084"/>
        <property type="gene ID" value="B6264_21180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35872">
        <property type="protein sequence ID" value="OEV35872"/>
        <property type="gene ID" value="HS99_0008405"/>
    </dbReference>
    <dbReference type="OMA" id="FNWPGHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="24070" checksum="2C5F888D16C72E74" modified="2017-01-18" version="1">MSLVLDRITLTYPDGDGRLTALDDVSLTVPKGTLTAVVGPSGSGKSSLLAVAATLIGPDSGRVVVDGTDTAGLDRAELTSLRRTRIGIVFQQANLLPSLTAAEQLQVMAHLDGRSPRSALPRALELLDAVGLHDQAHRRPHQLSGGQRQRINIARALMNDPTVLLVDEPTSALDHERGAAVLELITELTHRRATATVLVTHDRTHLTAVDQIAEVHDGRLVVPSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6C9</accession>
    <name>A0A1E7N6C9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">HS99_0030820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284214.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000574.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8036"/>
    <dbReference type="EnsemblBacteria" id="ARF79847">
        <property type="protein sequence ID" value="ARF79847"/>
        <property type="gene ID" value="B6264_13875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36235">
        <property type="protein sequence ID" value="OEV36235"/>
        <property type="gene ID" value="HS99_0030820"/>
    </dbReference>
    <dbReference type="OMA" id="QFVFKNA"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="241"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="32721" checksum="7232176D94090539" modified="2017-01-18" version="1">MSGSRIVALGHYQPPKVLTNDDLAAFVDTDDEWIRTRVGIRTRHIAEGETLVDLAAEAAQKALANSGRTAAEIDLVVVATCTAIERSPHTAAAVAARLGVRSPAAYDINTVCSGFSYALATADHAIRAGAARRALVIGAERMTDTLDWTDRSTCVIFGDGAGAAVVEAQEEGAEPGIGPVVWGSEPERGDAVVITGWDPVISQQGQSVFRWATTQLAPLAREACERAGLDPSELKGFVPHQANLRIIDAIAGKLGLADAVVARDVVDSGNTSAASIPLAFSKLVERGELSPGDPVLLFGFGGGLAYAGQVVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G0</accession>
    <name>A0A1E7N6G0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366945.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2640"/>
    <dbReference type="EnsemblBacteria" id="OEV36280">
        <property type="protein sequence ID" value="OEV36280"/>
        <property type="gene ID" value="HS99_0030190"/>
    </dbReference>
    <dbReference type="OMA" id="WRCHDDG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1528"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1502"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1838" mass="199699" checksum="E3308A39CA9177E0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G2</accession>
    <name>A0A1E7N6G2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283553.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000315.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2652"/>
    <dbReference type="EnsemblBacteria" id="OEV36269">
        <property type="protein sequence ID" value="OEV36269"/>
        <property type="gene ID" value="HS99_0030130"/>
    </dbReference>
    <dbReference type="OMA" id="KFVNYHV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025438">
        <property type="entry name" value="DUF4180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13788">
        <property type="entry name" value="DUF4180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4180" evidence="1">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13126" checksum="F7F0DA3A1368BE3F" modified="2017-01-18" version="1">MADTVRELSGVKVLVCDPAGPSITTVQDALDLIGATYDGAELVAVPADRLDDTFFVLSTGFAGEVMQKFVNYHVRLVVLGDISRHLEASSALRSLVVESNRGSHIWFLADTDALAARLEPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y4</accession>
    <name>A0A1E7N6Y4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenazine biosynthesis protein PhzF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554253.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene231"/>
    <dbReference type="EnsemblBacteria" id="ARF82259">
        <property type="protein sequence ID" value="ARF82259"/>
        <property type="gene ID" value="B6264_28330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36435">
        <property type="protein sequence ID" value="OEV36435"/>
        <property type="gene ID" value="HS99_0029285"/>
    </dbReference>
    <dbReference type="OMA" id="FHVRDPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="29836" checksum="EE9E73E25C3CA3EF" modified="2017-01-18" version="1">MTDDAPEILRYAAFAIRPEGGNPAGVVLDATGLTEERMLAVAAEVGYSETAFLTPGDARDTYRVRYFSPLTEVPFCGHATVASAVALADRIGPGRFVFSTAAGDVPVEVERGADGLRATLTSVEPKVEEVPAADVEEALALLGWAAADLDPAFPPRIGYAGARHLVLAAGTRARLARLDYDFDGLAAFMRARDLVTLQLVWREAAEVFHVRDPFPVGGVVEDPATGAAAAAFGAYLRELGAVTAPTVLTLHQGEDLGRPGVLRVELRAEDSRVRVSGTAVAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N761</accession>
    <name>A0A1E7N761_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289005.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000382.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1472"/>
    <dbReference type="EnsemblBacteria" id="ARF79190">
        <property type="protein sequence ID" value="ARF79190"/>
        <property type="gene ID" value="B6264_09885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36509">
        <property type="protein sequence ID" value="OEV36509"/>
        <property type="gene ID" value="HS99_0028695"/>
    </dbReference>
    <dbReference type="OMA" id="LMEHKNQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="28086" checksum="44443A7BA750DA35" modified="2017-01-18" version="1">MTPSADDRTTAEAGHPSARLLVVDDEPALRDALESSLAFEGYEVATATDGYEALESVERDKPDLVLLDIMMPRMDGLTAVRRMRSRGDTVPVLMLTARDAVGDRVTGLDVGADDYLAKPFELDELLARVRALLRRNALAAEAAARAAAEDDSEVLAFGDLRMNTATREVTRGGKPVELTRTEFMLLEMFLSHPRQVLTREQILKAVWGFDFEPSSNSLDVYVMYLRRKTEQGGMPRLIQTVRGVGYALRPAAGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B4</accession>
    <name>A0A1E7N7B4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557574.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7181"/>
    <dbReference type="EnsemblBacteria" id="ARF82344">
        <property type="protein sequence ID" value="ARF82344"/>
        <property type="gene ID" value="B6264_28810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36363">
        <property type="protein sequence ID" value="OEV36363"/>
        <property type="gene ID" value="HS99_0029845"/>
    </dbReference>
    <dbReference type="OMA" id="DGPNLAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="347" mass="36832" checksum="EFAD90CBDC637C19" modified="2017-01-18" version="1">MAVFGCAGCGAELTAPVTEVALPPHAHREGGDRYLPPLLEPGTFALDPEPSERPWRPWSSISPAEAAALGVYAPVDGLWSGDGGAALLAPGDTRGTALIPERCDGCCACAGGPNLACERCGRTVGARIDDCYRWQAVWLYPRAVRRLPVQGPARPAGDGWTAAPTPPVEPLGWWSDRWSAAVGAALAEVLAASGGAPVAVAPGLLAETFGRTLQRLLPAGAPVRTLGPAGPGLTPAPMPDIALVPRHPWTGAAWRPPSGGTVPVPLDAGVWTYLAFPPVRPTTRLPAGEERDDPLPLRPNRLFEPDRRLLRHRLARLPAVRQPWLRAIYDRLGDRRHHSRTATEGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G3</accession>
    <name>A0A1E7N7G3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7909"/>
    <dbReference type="EnsemblBacteria" id="OEV36574">
        <property type="protein sequence ID" value="OEV36574"/>
        <property type="gene ID" value="HS99_0029075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="73" mass="8434" checksum="674D02ED9F0155FF" modified="2017-01-18" version="1">MWRLSPNRVTEEEQQTVPMRHEEARIEREPITEANRGAAMSGETISEAEHEVTLHAERPVVHTEPSRWNGCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7H1</accession>
    <name>A0A1E7N7H1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550746.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2527"/>
    <dbReference type="EnsemblBacteria" id="OEV36652">
        <property type="protein sequence ID" value="OEV36652"/>
        <property type="gene ID" value="HS99_0028200"/>
    </dbReference>
    <dbReference type="OMA" id="RRSFRCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="387" mass="40881" checksum="B24836F376F78DE6" modified="2017-01-18" version="1">MADRLTGGDSSLLRRINAAVTLRALRTGHSVTLTQLVGETGLSRPTVEGVIEGLVETGLVAEVEQPREDGQPGTGRRGRPARWFRFRAEAGHILGIEIGVHDIRVILADLTGEVVGSHFKPVDETLDAEERLTAVRAAVAEVLRKAGISRDNLWAVGIGTPGIVDREGTIRLGTAMPGWTGLDLGARLRRSFRCPVLIENDANLAAIAEHWQGAAVGADDVVFVMAGLSPGAGSLINGKLHRGYGGAAGEIGALHLLGQEVTPEKLLSTTGKPLNPLDEAAVARVLRLAREGDEVAKVAMDRFLTRLVQGVAALVLAIDPQLVVIGGWAAGLDGVLEPLRERLAQFTLRAPEVALAALGSEVVSMGALRVALDHVEDQLFAVDPPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J0</accession>
    <name>A0A1E7N7J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550728.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2511"/>
    <dbReference type="EnsemblBacteria" id="ARF81493">
        <property type="protein sequence ID" value="ARF81493"/>
        <property type="gene ID" value="B6264_23565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36666">
        <property type="protein sequence ID" value="OEV36666"/>
        <property type="gene ID" value="HS99_0028280"/>
    </dbReference>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="41630" checksum="4B598801E733EEEC" modified="2017-01-18" version="1">MTLPLTPAPHTAAGLAPAHVFDWLDEAAELRADAGLTRRLRSRGAEDQVLDLAGNDYLGLTRHPVVTRAAGEAALRWGGGATGSRLVTGTTALHTELEQELAEFCGAEAALVFSSGYTANLAALTALTDPDTLIVSDAYNHASLIDGCRLARADVHRAPHSDPAAVAEILAGRAQRRALVVTDSVFSVDGDAAPLRGLSKAVRAHGAALLVDDAHGLGVLGPGGRGALAAAGLAGQPDTVATVTLSKSLGSQGGAVLGPRRVIRHLTETARTFIFDTGLAPAAAGAALAALRLLRAEPQRADRAREVARTLAARLTAAGLHACEPDAAVVSVRAPGPEAAVTWAADCLRAGLAVGCFRPPSVPDGISRLRLTARGDLTDTQITDAVRTIANLAPAGAISVDRTGTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J2</accession>
    <name>A0A1E7N7J2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="1">TDH</shortName>
            <ecNumber evidence="1">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdh</name>
        <name evidence="2" type="ORF">HS99_0028310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278875.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2504"/>
    <dbReference type="EnsemblBacteria" id="ARF81499">
        <property type="protein sequence ID" value="ARF81499"/>
        <property type="gene ID" value="B6264_23600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36672">
        <property type="protein sequence ID" value="OEV36672"/>
        <property type="gene ID" value="HS99_0028310"/>
    </dbReference>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="342" mass="36433" checksum="12E5447F972678C7" modified="2017-01-18" version="1">MKALVKHNAEPGLWLMDVPKPEIGPGEVLIKVLRTGICGTDLHIRKWDGWAQQTIRTPLVLGHEFVGEVAEIGAGVADIAIGDLVSGEGHLVCGKCRNCLAGRRHLCRNTIGLGVNRDGAFAEYVALPASNVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLVTGAGPIGIMAAAVAKHAGARSVMITDVSPYRLDLAREVGVTLALNVAEHTIEEGQQKLGLREGFDVGLEMSGRPEAMQSMIANMTHGGKIAMLGLPAEQFPVDWASVVTSMITIKGIYGREMFETWYAMSVLLEGGLDLSPVITGRYAATDFEAAFDDAASGNCGKIILDWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R3</accession>
    <name>A0A1E7N7R3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0027920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7760"/>
    <dbReference type="EnsemblBacteria" id="OEV36708">
        <property type="protein sequence ID" value="OEV36708"/>
        <property type="gene ID" value="HS99_0027920"/>
    </dbReference>
    <dbReference type="OMA" id="HYALCEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18655" checksum="5B817602C6ABA8C7" modified="2017-01-18" version="1">MAEIHRLHGGYLLRALMRTTGGDRGKAEDILQETLLRAWQHPEALAAGPEQARPWLFTVARRIAIDHYRMAAARAKEVIGEPVEDRPLADDPYEQVVVARDLALALRRVQKHHREVLVELHLKDRSVVEASARLGVPPGTVKSRNFYAVRALRPVLAAEHGYAPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8J3</accession>
    <name>A0A1E7N8J3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV36974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000468.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81755">
        <property type="protein sequence ID" value="ARF81755"/>
        <property type="gene ID" value="B6264_25205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36974">
        <property type="protein sequence ID" value="OEV36974"/>
        <property type="gene ID" value="HS99_0003810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="14902" checksum="2FF17BE8B604649C" modified="2017-01-18" version="1">MTDDYQQREEWRAAFAKQVITDCLGQWLRSANEAAVAAVGSEYAAESARLARQAKDKLTRWRERGDLGGDTAARIADAVVERMEHDEKTTPPREEADESFPSFDSSYRAAVTCQWLRDQGYDIPTYPGNPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L2</accession>
    <name>A0A1E7N8L2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366123.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7466"/>
    <dbReference type="EnsemblBacteria" id="ARF81690">
        <property type="protein sequence ID" value="ARF81690"/>
        <property type="gene ID" value="B6264_24805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37036">
        <property type="protein sequence ID" value="OEV37036"/>
        <property type="gene ID" value="HS99_0004200"/>
    </dbReference>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="403" mass="42559" checksum="C9BD72E77A3137D1" modified="2017-01-18" version="1">MADRLAGAQVPPSTPTTPPTPPADGFWCAPDDSRWALAGRGADRLAAVRTKLARIDPRCADLPLLVADAADREALRAVAADARVVVSTVGPYLRHGEPLVAACADSGTDYVDLTGEPEFVDRMYLRHHERALATGARLVHACGFDSVPHDLGVLFTVEELLRRGGPAARVSVEGFVRAGGTVSGGTFASAMTAFSRPRAMARAARARRAVEPRPKGRLVRTPAGRPHRSRAARAWALPLPTIDPQVVSRSAAALENYGPDFGYAHYAAVRRLPIALGGVAAVAALAVAAQLPLLRRALGRLRKPGDGPGAEQWARSWFAVRFVARAHDGRTVLTEVSGGDPGYQETAKMLAESALCLAYDDLPPLAGQLTTAVAMGRPLIDRLVAAGISFRVLDTPPATAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N900</accession>
    <name>A0A1E7N900_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555694.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81595">
        <property type="protein sequence ID" value="ARF81595"/>
        <property type="gene ID" value="B6264_24210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37138">
        <property type="protein sequence ID" value="OEV37138"/>
        <property type="gene ID" value="HS99_0004785"/>
    </dbReference>
    <dbReference type="OMA" id="ESHAYQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="128" mass="13971" checksum="73A4A68D2D074F5A" modified="2017-01-18" version="1">MGNQEAAPEQTLPTFEEAKGLGPQDSQFVRDLVEVLEKHGNLDRFGLCLLHEHFPVAGDEVLVETHDLAARTLQIRVEKAGATGHTKPSQWRFVKTGHDSGEVESHAYQVILQCSPISGCPGSRGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N907</accession>
    <name>A0A1E7N907_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555674.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000451.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6634"/>
    <dbReference type="EnsemblBacteria" id="ARF81585">
        <property type="protein sequence ID" value="ARF81585"/>
        <property type="gene ID" value="B6264_24155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37148">
        <property type="protein sequence ID" value="OEV37148"/>
        <property type="gene ID" value="HS99_0004835"/>
    </dbReference>
    <dbReference type="OMA" id="GDLHHYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="613" mass="66989" checksum="6B317D45649C20C1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N936</accession>
    <name>A0A1E7N936_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6165"/>
    <dbReference type="EnsemblBacteria" id="OEV37202">
        <property type="protein sequence ID" value="OEV37202"/>
        <property type="gene ID" value="HS99_0005170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198981" description="PG_binding_1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="130" mass="13678" checksum="CF143B009EDDA98B" modified="2017-01-18" version="1">MTAKSFGRAVLAGAVAGTALLGLAGSASASDTAGYIGDGYANNSQAVWCVQHLINDVARNNNRATIDEDSIWGPQTKDQVLWFQAFVHVQPDGIVGPFTGDNILYRGDQKYGGKSGSCFAYVPSDSGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A3</accession>
    <name>A0A1E7N9A3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4383 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481050.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1322"/>
    <dbReference type="EnsemblBacteria" id="OEV37248">
        <property type="protein sequence ID" value="OEV37248"/>
        <property type="gene ID" value="HS99_0005455"/>
    </dbReference>
    <dbReference type="OMA" id="DNPYWRR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="18303" checksum="EFA270C64E2FF896" modified="2017-01-18" version="1">MKLHEELPVDHRLSRVYRAGAGLCGAALLAFGCLGLSDGLPFFSTDGEKIAGLSSNGLLSLVSVVTAAVLLGGALIGGNIASTVNITVGALFVLSGFVNLALLDSSANILAFRIQNVLFSFVMGLVIATFGMYGRVSGKLPLDNPYWRHRHPGPSERHDAPALPLGSPAAGLPGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C0</accession>
    <name>A0A1E7N9C0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0005650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555143.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1285"/>
    <dbReference type="EnsemblBacteria" id="OEV37279">
        <property type="protein sequence ID" value="OEV37279"/>
        <property type="gene ID" value="HS99_0005650"/>
    </dbReference>
    <dbReference type="OMA" id="ERPPIFT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="489" mass="49944" checksum="9B6C2A7CC30B5F1E" modified="2017-01-18" version="1">MPPAVARAGAPPRRRLGLILALLAFAQCIYAIDYSIVFVALPEIRTGVGFSAQNLQWVVSAYAVAFGGFLLLGGRAADLFGRRRMFAFGLFLYAASSLAGALAGDPTTLIVARAVQGIGGAFLAPATLSLVTTTFAEGPERNRALAIWGGAGGSGMILGSLLGGVLTGAFGWASIFYANVPLAGGAMLLTFVIIPKDTDHGTSGRKFDLPGALTATVGSTLLVFTLVQGPVSGWTSPTILITAAIAVIVLTAFFTIEGRGRDPLLPLRLFRNRNLSTGSVVTFIFMGTFGALPYFYTLYFQSVHGYSATKSGLAFLVPCVGVLIGNLSGGKLATRFGVRATLIGALLTGVVGTVAFAFSVSPSGTYLEFVPGVLVLSLGQGTVFTAMYAAATTGVAAEDQGIASGVASTGQQVGAAVGLAVLVAIANSGHEGLTGEALRVATSDGVRTAMWASVVGMVAIVLVALNFRRSTAVPAAEVSEKQDGVASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9C9</accession>
    <name>A0A1E7N9C9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37296">
        <property type="protein sequence ID" value="OEV37296"/>
        <property type="gene ID" value="HS99_0005755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="11958" checksum="F92870C9366BE1CE" modified="2017-01-18" version="1">MGRRRRRASLGRTASSSRLCTFYRIVSASLRKPRVLYGLPYGGVVWLSGYVVLPIAGLHKPIWTYDAKTLGDDLTAHLAYGVVHEQRFLVAEQGFRVLAATAVRDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9D9</accession>
    <name>A0A1E7N9D9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1251"/>
    <dbReference type="EnsemblBacteria" id="OEV37306">
        <property type="protein sequence ID" value="OEV37306"/>
        <property type="gene ID" value="HS99_0005815"/>
    </dbReference>
    <dbReference type="OMA" id="LIDHTYE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="42139" checksum="AB9758DC08A43AA6" modified="2017-01-18" version="1">MPDPIGQARQLPQYFGVLPEYRGLRPGRRLWRAAMHWEHANGADYQLLQTTASGASDQLCQDLVDQDRPDPWVPSAGPRQLMVSMYYPAWSGTGRPAPFMTTQEATDFLASEGLGGAFPAQTLVDTRTYAYAGARPEHGKYPMVVLSPGLELPRQTLTGLAVDLASRGYVVALVNHTYEDSGTTFPDGRTLGCTTCGDTGPAPDQMERSRAEDVSFVLDQLTGHHPAWQKAQLIDRKRIGMAGHSLGGAAVVPTMTADQRVRAGADLDGRLFVPVPSGGLGGRPVLLLGNPENHAVGGDESSWAANWPSLDGRKRWLTITGSNHVSFTDVPVLADEAGITGVDGSIPAVRAERLTRDYVAAFFDEHLKGIPQPLLDGPSPVDPEVVFQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F7</accession>
    <name>A0A1E7N9F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556514.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5468"/>
    <dbReference type="EnsemblBacteria" id="OEV37327">
        <property type="protein sequence ID" value="OEV37327"/>
        <property type="gene ID" value="HS99_0005945"/>
    </dbReference>
    <dbReference type="OMA" id="CCYALQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="17790" checksum="25817EE22DDA4DA0" modified="2017-01-18" version="1">MSRVQLALRVADLEGSIAFYSKLFDAEPAQRRPGYANFAITEPPLKLVLIEGEAGEDTRLDHLGIEVETTEQVTAATRLLKDAGLATFEENDTSCCYALQDKTWVTGPGKEPWEVYVVKADADTLGKSDAAPEACCGTTACCTPDEQAVDPTQSPAEAKAAAGCACGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N3</accession>
    <name>A0A1E7N9N3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558121.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000649.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000093_gene118"/>
    <dbReference type="EnsemblBacteria" id="OEV37401">
        <property type="protein sequence ID" value="OEV37401"/>
        <property type="gene ID" value="HS99_0006395"/>
    </dbReference>
    <dbReference type="OMA" id="WVGRRVW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="32916" checksum="F08C61E2E053BB56" modified="2017-01-18" version="1">MKAVVIRTFGDPDGLEVVDVPVPVPAPGQVRIATEAIGVGGVDAVIRRGTLAAYGFREGHLLGSEVAGRVTAVGEGVDASWLGRRVWAFTGLSGGYAEQAVASVEDVLALPDGLTGADAVTLGGSGVVAHFALDRARFTPGETVLVRGAAGSIGITAVQLAARDRAGAVAVTTSSAERGARLRDLGATHVLDRSGENGPDTPAGFDVVIDVVGGPQLPLFLDRLNSNGRYVAVGVVGGQPPADFGMRLMDAFRRSLSFATFSSDTVTGPDRQAVRSSQFADAAHGDLHTVVHEVLPLDQAVRAHRAMDAGEVFGRVVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9N7</accession>
    <name>A0A1E7N9N7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558126.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000649.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82515">
        <property type="protein sequence ID" value="ARF82515"/>
        <property type="gene ID" value="B6264_29885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37405">
        <property type="protein sequence ID" value="OEV37405"/>
        <property type="gene ID" value="HS99_0006415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="28313" checksum="9EF6CD227B01AE21" modified="2017-01-18" version="1">MTDWASYAGKVVDATWTLRRDAEQALGTKHADLSLILSGKGLPCMEWLSILHRALEAAGYFVEEEERETSYALYMAALKEIAEAEQRGEPRRVRAIGWKHKRASAHYELEQTRERARRERDEAEQLRIATGQAAEQQRGEPEGENNLDDGQAQGPVRQARPRPLAVIADFTGAVVGLLLTLPLAFRREVVFTQVLKGIDTEYRFTAYPVAQWMDLVDLVFLLLGNVATALAVSTIVCSFQLHPAPAWWSPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U1</accession>
    <name>A0A1E7N9U1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5972"/>
    <dbReference type="EnsemblBacteria" id="OEV37414">
        <property type="protein sequence ID" value="OEV37414"/>
        <property type="gene ID" value="HS99_0004035"/>
    </dbReference>
    <dbReference type="OMA" id="FVMRIRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15512" checksum="EC4ABEA74AF0A6EB" modified="2017-01-18" version="1">MTPREVFTKLLDNIAAGRYAELAGLYAADAVVETVFEPVGPRRTEGRAALEERFAQVAAVSPVELTPANVVIRETDDPEVIVAEWDYQVRHRPTGKTFQSANIQVLKVRDGLIVHSRDFHDHLALIAATGALPQLVAALDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA95</accession>
    <name>A0A1E7NA95_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290452.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6256"/>
    <dbReference type="EnsemblBacteria" id="ARF79875">
        <property type="protein sequence ID" value="ARF79875"/>
        <property type="gene ID" value="B6264_14040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37620">
        <property type="protein sequence ID" value="OEV37620"/>
        <property type="gene ID" value="HS99_0025255"/>
    </dbReference>
    <dbReference type="OMA" id="HMHLDKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="42636" checksum="45BC476C3BC5D811" modified="2017-01-18" version="1">MDSAAPDGPHSGPDPAANPLGHGPVLLLTGARLADGRVVDVRISGDRIQAVGTVGSLGPLPALPGAPTVTTGARIDLRGYLLLPAPAEAHAHYDSAFSAALPAPPPDTPADLTRRVTEAALTSLGYGATAQRTHVRIGDVHGLHPLEAVLTARQALRGLADLQAVAMPRLLTGRAGADGRAQLREALKLGATAAGGCPELDPDPAGYVQLLLEAAREADCPVDLHTTAADAAQLARLASALAPLRPRVTLGPCGALARGASTVLATSGVRVVWLPQNGGCTGLEGRPSGQRPGLVRELTAARVPLAAGSGALRDQSNPVGRADPLESAYLLAAGGELDPEAAYDAVANQARAALGLPPVRVDAGFPAELLAVRGDSLAGALAGGHSRLVVHSGRVVSRTSAVREFADTVALALPRQSDGADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAB5</accession>
    <name>A0A1E7NAB5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6185"/>
    <dbReference type="EnsemblBacteria" id="OEV37433">
        <property type="protein sequence ID" value="OEV37433"/>
        <property type="gene ID" value="HS99_0005085"/>
    </dbReference>
    <dbReference type="OMA" id="WPFERAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="836"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="907" mass="95298" checksum="E6F0BBA3744A84A1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAR4</accession>
    <name>A0A1E7NAR4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0026520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366615.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37563">
        <property type="protein sequence ID" value="OEV37563"/>
        <property type="gene ID" value="HS99_0026520"/>
    </dbReference>
    <dbReference type="OMA" id="HAPGFSF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="101"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="34798" checksum="D83B665BE9FF6910" modified="2017-01-18" version="1">MHLTNSTTSVTVRQRRLLRDASLALGCAALFCLLATLVTGRWHPLYQFDQDWTSELHDYARDHRIWTAAVQTLSDIGGPVTMRALLGIAAAWLWLIGARVLAGWVAAQALVGWGAQWALKLAVGRQRPAFSDPVAHAGGPAFPSGHAMASAITCAVLVGLLWYRVQRRGRTAACAVAAATVLTIGWTRTALGVHWPSDVLAGWLAAGVVLGVVTAAIELWRPGALARDVRRVNWRTRPRVQRVIVPYDRTPRPDGPLDDGPSSDGPSDRGAPAGDPRNADPRNADPRNADPRNHDPLDDGPPAGAESDVPGRDDPADRPDAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV5</accession>
    <name>A0A1E7NAV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556761.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6032"/>
    <dbReference type="EnsemblBacteria" id="ARF78035">
        <property type="protein sequence ID" value="ARF78035"/>
        <property type="gene ID" value="B6264_03055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37830">
        <property type="protein sequence ID" value="OEV37830"/>
        <property type="gene ID" value="HS99_0024930"/>
    </dbReference>
    <dbReference type="OMA" id="SVAMRGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="352" mass="35865" checksum="4788F871B8DE8401" modified="2017-01-18" version="1">MTAATAATGRRPTRTARAGLVASALSLALVLALTLAVSLGAVDIPVREVWTVVGHRLTGSAPEAGTRDLIVWQLRVPRALLAAIVGAGLGLVGTAVQALVRNPLADPYLLGISSGASLGAVAVIVLGAGTGFAFGFGVPAAAFAGALASFALVWAIARRGGGFAPMRLVLAGVAIGQFLSGFTSFLILQAGDEQQTRGVLFWLMGSLGAATWDQLAVPAAAVALGWLALQGRARHLNALLMGDETAAGLGVDPSRLRRELFAVTSLLTGVLVAVSGAIGFVGLLVPHVCRLVVGGDHRRLLPLSALTGAVLLVAVDTVARTALDTQELPIGVVTAVIGAPVLLYLLDRKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV7</accession>
    <name>A0A1E7NAV7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoK</name>
        <name evidence="6" type="ORF">HS99_0025150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284186.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000245.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8024"/>
    <dbReference type="EnsemblBacteria" id="ARF79857">
        <property type="protein sequence ID" value="ARF79857"/>
        <property type="gene ID" value="B6264_13935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37603">
        <property type="protein sequence ID" value="OEV37603"/>
        <property type="gene ID" value="HS99_0025150"/>
    </dbReference>
    <dbReference type="OMA" id="FDVWLSR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="13130" checksum="AE89236EA0DF5A95" modified="2017-01-18" version="1">MHLAYPVVLSALLFSVGVYGVLARRNAVLVLMSVELMLNAVNLNLVAFDAWLRDSLHAGQALTLFTITVAAAEIGLGLAIVLLLFRARGTADIDRATALGDPAEPYASVEEEPAAAEALKGRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAY4</accession>
    <name>A0A1E7NAY4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene5997"/>
    <dbReference type="EnsemblBacteria" id="ARF78010">
        <property type="protein sequence ID" value="ARF78010"/>
        <property type="gene ID" value="B6264_02875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37851">
        <property type="protein sequence ID" value="OEV37851"/>
        <property type="gene ID" value="HS99_0025090"/>
    </dbReference>
    <dbReference type="OMA" id="HDGRCEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19917" checksum="5FAA9E193CE33DBE" modified="2017-01-18" version="1">MDTVTTHSPQSARPGHGLTVADAMEPCDYQTADDSTVDQANDIFRDADIEYRPVRDHDGRCEGLVTRAGLHPFLARSWYTELTTISATSHQRGPFAWPTMGLALAAIAMRIEHLAVWPVVDEDGHILGVLTAARATGLCSPSHRLREAVGAPRCSARTGRTDETRARRRTRPLSSRVLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB15</accession>
    <name>A0A1E7NB15_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">HS99_0025565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280768.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1681"/>
    <dbReference type="EnsemblBacteria" id="ARF79930">
        <property type="protein sequence ID" value="ARF79930"/>
        <property type="gene ID" value="B6264_14355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37673">
        <property type="protein sequence ID" value="OEV37673"/>
        <property type="gene ID" value="HS99_0025565"/>
    </dbReference>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV37673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="105" mass="11604" checksum="07966A0509FA2D76" modified="2017-01-18" version="1">MSDVTSKTFTDPRDVLVKPVISEKSYSLLDENKYTFIVSPGANKTQIKQAVEAVFSVKVEAVNTINRQGKRKRSKTGFGKRKDTKRAIVTLAEGNRIDIFGGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBE0</accession>
    <name>A0A1E7NBE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV38026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2002"/>
    <dbReference type="EnsemblBacteria" id="OEV38026">
        <property type="protein sequence ID" value="OEV38026"/>
        <property type="gene ID" value="HS99_0024390"/>
    </dbReference>
    <dbReference type="OMA" id="TDLYHAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22654" checksum="EBB0070E5E5861DA" modified="2017-01-18" version="1">MFGAQEAGEPDYALSTDQQAAQRRSGFRLLRGGRKPAEDRPTLTDLYHAHRLGLVRMAVLLVDHQDLAEDVVQEAFTQLYQRHGEHLDDLDNALGYLRTSVVNGARSMLRRRRTAREYVPPHEADAPSAEDHAVLNDEHRRVLVALQELTPRQREVLVLRYWSDMSEAQISETLGLSRGAVKSTASRALDALEKHLEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBP2</accession>
    <name>A0A1E7NBP2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine efflux protein LeuE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556803.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000699.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79681">
        <property type="protein sequence ID" value="ARF79681"/>
        <property type="gene ID" value="B6264_12890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38112">
        <property type="protein sequence ID" value="OEV38112"/>
        <property type="gene ID" value="HS99_0023215"/>
    </dbReference>
    <dbReference type="OMA" id="AGVWCGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="23104" checksum="B8792F415871BF1A" modified="2017-01-18" version="1">MFGVNDLTTYVLGALVIILLPGPNSLYVLSVAARKGIRTGYRAAAGVFVGDLTLISLTSLGAASLLKANPAVFAVVKFGGAAYLLWIGFGMLRAARQLWRERRAEADPADGAEAAVEAGERPFRRALVISLLNPKAILFLLSFFTQFVDPSYGQPALSFALLGGILQTFSLLYLSLLIFAGTTLATAFRRRRRLSATLTSGVAVLFAGFAAKLAVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC12</accession>
    <name>A0A1E7NC12_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0022010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366772.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000369.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3325"/>
    <dbReference type="EnsemblBacteria" id="ARF80260">
        <property type="protein sequence ID" value="ARF80260"/>
        <property type="gene ID" value="B6264_16270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38230">
        <property type="protein sequence ID" value="OEV38230"/>
        <property type="gene ID" value="HS99_0022010"/>
    </dbReference>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV38230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="814" mass="83397" checksum="B768C672523A6765" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC68</accession>
    <name>A0A1E7NC68_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366761.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000140.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4182"/>
    <dbReference type="EnsemblBacteria" id="ARF80186">
        <property type="protein sequence ID" value="ARF80186"/>
        <property type="gene ID" value="B6264_15835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38296">
        <property type="protein sequence ID" value="OEV38296"/>
        <property type="gene ID" value="HS99_0022435"/>
    </dbReference>
    <dbReference type="OMA" id="IASNWTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16102" checksum="7A946EE54AF5CA0A" modified="2017-01-18" version="1">MTNRHTSDADPPPGPGEPEDVPLEFAAFCELHRPRYLSYARVWLTEHAHAATAVQQAFAEIAVQWRELLTSPNPTALAWQILRGTVAEHTRRETPAPDRHPADDDLAILHYVVGLAAPEIADVIGTDTASVAGRLRRTMLHEASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC99</accession>
    <name>A0A1E7NC99_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030059737.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4147"/>
    <dbReference type="EnsemblBacteria" id="ARF80158">
        <property type="protein sequence ID" value="ARF80158"/>
        <property type="gene ID" value="B6264_15655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38319">
        <property type="protein sequence ID" value="OEV38319"/>
        <property type="gene ID" value="HS99_0022620"/>
    </dbReference>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9768" checksum="A0D4678F61DBC753" modified="2017-01-18" version="1">MNRSELVAALSERAEVTRKDADAVLAAFAEIVGEVVAKGDEKVTIPGFLTFERTHRAARTARNPQTGEPIQIAAGYSAKVSAGSKLKEAAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCG5</accession>
    <name>A0A1E7NCG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283247.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene246"/>
    <dbReference type="EnsemblBacteria" id="ARF82227">
        <property type="protein sequence ID" value="ARF82227"/>
        <property type="gene ID" value="B6264_28105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38382">
        <property type="protein sequence ID" value="OEV38382"/>
        <property type="gene ID" value="HS99_0020950"/>
    </dbReference>
    <dbReference type="OMA" id="IGYWSWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="17020" checksum="0E7DBE4D6EA9DB56" modified="2017-01-18" version="1">MEYSHSDDELVKQPIGYWSWAAYKAVVSRTRGALAELGTTQPQWWVLAQLARAEAPRTRDDVCAVLRDYLDTGQDTVETEIDATVERGWVTESAGGRLQLTAGGRTFFDKVAAVQGELWAERHAGISDEEYLTTLKVLQRFVHNTGGTAWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCG7</accession>
    <name>A0A1E7NCG7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copper-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283232.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene253"/>
    <dbReference type="EnsemblBacteria" id="ARF82220">
        <property type="protein sequence ID" value="ARF82220"/>
        <property type="gene ID" value="B6264_28070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38389">
        <property type="protein sequence ID" value="OEV38389"/>
        <property type="gene ID" value="HS99_0020985"/>
    </dbReference>
    <dbReference type="OMA" id="HCERTVS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="6828" checksum="63AE711F9F1080E0" modified="2017-01-18" version="1">MSITTVLAVDGMSCGHCERTVSAGLAAIPGVIDVVADAPSGRVTVASAGPLETAAVRSAVDGAGFTLVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCY0</accession>
    <name>A0A1E7NCY0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3110"/>
    <dbReference type="EnsemblBacteria" id="ARF83099">
        <property type="protein sequence ID" value="ARF83099"/>
        <property type="gene ID" value="B6264_27300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38542">
        <property type="protein sequence ID" value="OEV38542"/>
        <property type="gene ID" value="HS99_0021745"/>
    </dbReference>
    <dbReference type="OMA" id="YDEPDAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="62"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="25478" checksum="03A4D1C974C534B2" modified="2017-01-18" version="1">MSGLLRRRAGGLRARLRERRTQRRVFQVTTLLCSLALAPSAWLWFAAGDRVGTVESAPSAPVAVVFGAGLDQGKPSPYLEHRLVAALDLYREGKVKAVLVTGDNGRTEYDEPDAMYRYLTEHGVPGDRVVRDYAGFDTWNSCTRAHRIFGVDRAVLVSQDFHVRRALALCEAAGIRSYAVGVPEPHDITWLYGGLREVAGAGKAAVNVLLRPDPEFLGPKEDGIPKALAAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDE6</accession>
    <name>A0A1E7NDE6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77713">
        <property type="protein sequence ID" value="ARF77713"/>
        <property type="gene ID" value="B6264_01150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38678">
        <property type="protein sequence ID" value="OEV38678"/>
        <property type="gene ID" value="HS99_0020735"/>
    </dbReference>
    <dbReference type="OMA" id="IHAFVAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="14642" checksum="ACC4CE4496A97109" modified="2017-01-18" version="1">MVGPAAVRSDSDLEVVREDPDAAPPGGTTTVRAFVANRGPDTTASPFTVIVTLPDGVTPQGPYFPADCAVLRGGHEVRCVFGAGLKQGRSATALVPVRVGLDVRLGMLTGGSVEVRSPDDRDRSNNRQPFDLNVVETAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDL3</accession>
    <name>A0A1E7NDL3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="10" type="ORF">HS99_0019195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290272.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7391"/>
    <dbReference type="EnsemblBacteria" id="ARF81205">
        <property type="protein sequence ID" value="ARF81205"/>
        <property type="gene ID" value="B6264_21930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38797">
        <property type="protein sequence ID" value="OEV38797"/>
        <property type="gene ID" value="HS99_0019195"/>
    </dbReference>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="185" mass="20547" checksum="1B9B7463B8688EC9" modified="2017-01-18" version="1">MSERPRLTVLSGPSGVGKSTVVAHMRKMHPEVWLSVSATTRHPRPGEKNGVQYHFVDNDEFDKLVANGELLEWAEFAGNRYGTPRAAVLEKLERGEPVLLEIDLQGARQVRESMPEAQLVFLAPPSWDELVRRLTGRGTEPQDVIKRRLEAAKVELAAEREFDTTLVNTSVEQVAAELLALLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV5</accession>
    <name>A0A1E7NDV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598512.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000631.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6528"/>
    <dbReference type="EnsemblBacteria" id="ARF81299">
        <property type="protein sequence ID" value="ARF81299"/>
        <property type="gene ID" value="B6264_22480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38891">
        <property type="protein sequence ID" value="OEV38891"/>
        <property type="gene ID" value="HS99_0019745"/>
    </dbReference>
    <dbReference type="OMA" id="LEFPPRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12522" checksum="D0D5D45222026CFA" modified="2017-01-18" version="1">MYLVHAALQPVPPGRPLPADARELLRSAVRPEDRVEHVVVHPEAFPDPVLGVYLLADSLAAAESRTAGFCRRALATVPEFAGWTATKVAAPLVTPFYERLLSAPAGPGRNGPGTFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEC6</accession>
    <name>A0A1E7NEC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557502.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1012"/>
    <dbReference type="EnsemblBacteria" id="OEV39049">
        <property type="protein sequence ID" value="OEV39049"/>
        <property type="gene ID" value="HS99_0018300"/>
    </dbReference>
    <dbReference type="OMA" id="NAYQLRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="545" mass="56204" checksum="3D184525FFCDF462" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI0</accession>
    <name>A0A1E7NEI0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557503.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1013"/>
    <dbReference type="EnsemblBacteria" id="ARF83280">
        <property type="protein sequence ID" value="ARF83280"/>
        <property type="gene ID" value="B6264_30565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39048">
        <property type="protein sequence ID" value="OEV39048"/>
        <property type="gene ID" value="HS99_0018295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="11740" checksum="3148F900511D1CF8" modified="2017-01-18" version="1">MGALRRSLETARKDGPAGEPKKSSGRTAARISHSPKQTGGKKSTSPKAATGKTTAKRASATGKQQLSQLTKAELYKRATDLDIPHRSPMTRDELQHALEHAGRPRRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEM2</accession>
    <name>A0A1E7NEM2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557134.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000342.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4079"/>
    <dbReference type="EnsemblBacteria" id="ARF83318">
        <property type="protein sequence ID" value="ARF83318"/>
        <property type="gene ID" value="B6264_30815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39085">
        <property type="protein sequence ID" value="OEV39085"/>
        <property type="gene ID" value="HS99_0018535"/>
    </dbReference>
    <dbReference type="OMA" id="ANKWALY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="136" mass="15129" checksum="5CFAE854B20D6B2E" modified="2017-01-18" version="1">MDTDSHRSHADLLATYRRSCPSRTVIEVLANKWSLYVLAALRRSPGPLRFSQLRRLLDGVTQKMLTQTLRALERDGLVARTVYPTVPPRVEYSLTDLGHAAGELTTAIADWAVDHASRVHAARAAFDARPEEPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV5</accession>
    <name>A0A1E7NEV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550111.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39178">
        <property type="protein sequence ID" value="OEV39178"/>
        <property type="gene ID" value="HS99_0000135"/>
    </dbReference>
    <dbReference type="OMA" id="WVIRETN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="16392" checksum="457E7E2EC53BDE4F" modified="2017-01-18" version="1">MTEPPPTPGRAQALDRLARAAYRLSAADARLRGRATRTPGALSLTHARALRTLADRGPLTITQLAAGTETTGAATTQLVNGLVSAGYVTRTRPPEDKRSVLVALTEAGRDRHRQRQQALAEALHSDLGDYDEEALDRAAEVLNRLSAVYDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF61</accession>
    <name>A0A1E7NF61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83350">
        <property type="protein sequence ID" value="ARF83350"/>
        <property type="gene ID" value="B6264_31010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39123">
        <property type="protein sequence ID" value="OEV39123"/>
        <property type="gene ID" value="HS99_0018740"/>
    </dbReference>
    <dbReference type="OMA" id="GERPANN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="602" mass="61412" checksum="0378D3A43E78EF09" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFB1</accession>
    <name>A0A1E7NFB1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367018.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39396">
        <property type="protein sequence ID" value="OEV39396"/>
        <property type="gene ID" value="HS99_0001450"/>
    </dbReference>
    <dbReference type="OMA" id="EERWHKD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199171" evidence="1">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="53"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="37645" checksum="D13B587CFA019201" modified="2017-01-18" version="1">MNATMRRAVIATAAVSMALSMAACGKAGGDKKDSAASGDNKSIGLLLPENASSVRYESFDKPFIEAKVKSLCADCKVLYNNAEGSAAKQKQQFDTLIAQGVKVIVLDAFDATSTESWVKEAAAKGVKVVAYDRLATGPVAAYASFDNEKVGELQGQALLDALGPQAADDNIVMINGDDADPNAGQFKAGAHKILDGKVKKVVYEQSGEWKPTVAGQKIGAAITQLGKDGFQGVYSANDGMAGAIITQLQGAGIKVPVGGQDAGLDAVQRIVNGDQAYTIYKAYKPLADSAAELAVDLLQGKDVKTVATTTVDSSTDKGIPAKLLDPKVVTKANIKDTVIADGLYKVSDICTADYAAACAAAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFE0</accession>
    <name>A0A1E7NFE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557676.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7532"/>
    <dbReference type="EnsemblBacteria" id="OEV39421">
        <property type="protein sequence ID" value="OEV39421"/>
        <property type="gene ID" value="HS99_0001600"/>
    </dbReference>
    <dbReference type="OMA" id="HAETHRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="43161" checksum="95B103F91DA030DA" modified="2017-01-18" version="1">MTDLNPVADGSVPAVDPRGWPLPRAVGLGDLGPLAEPISEHNGQAVAVRPLTDHPGWLAKLYRPDPHPEDAQRIDLLISAPDTLPESERATLYAGTCWPAARIHGPGNPAVGCVIPMAPEHYRAELRRGKFSERRFLEIDWLAKSDESIRGVGLPRPAFGDRLEACRRLTELAAILEALGLVYSDWSFSNAFWSPDRRSVYLIDVDGCQPQKMPDIHQPNWADPLTPPGSDADHCTDRYRLGLLVAKCLTGQRDARAFHSVSLSPWPEQPALSEVLLDMLFATERERRPTAVQLNQALNNGPYLRTVPRPTRSALPPLPPLPASQTVPQPPAGTGAAETGTADTGTAKSGTVAEGTVVTRTTEKKKDPATTWNARWIWAFAFAVILLIVISIASNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF0</accession>
    <name>A0A1E7NFF0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557684.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7542"/>
    <dbReference type="EnsemblBacteria" id="OEV39431">
        <property type="protein sequence ID" value="OEV39431"/>
        <property type="gene ID" value="HS99_0001650"/>
    </dbReference>
    <dbReference type="OMA" id="QNNLAMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="49658" checksum="D654CA3DE6B02103" modified="2017-01-18" version="1">MSHRGPRVLRLDALARVEGEGALRLTVNDGTVAEARLKIYEPPRFFEAFLVGRGHYEPPDITSRICGICPVAYQMTACQAIERACGVTIDDQLAELRRLLYYGEWIESQSLHIHLLHAPDFFGCPSAVELAREQREAVERGLRIKQAGNAVMEQLGGRAIHPVNVRIGGFHRVPARAELAPLAERLRRIQEDAVETVRWVAGFDFPEASCDYDLLALQDPGRYAIDSGTPAAMAAPDSPGSDRAGPVRRFAVDEFEQHVVERQVPHSTALQSELDGRRYLTGSLARYAIGGRWLHPLAAEAARAAGLGDPAAGAVVRNPFRSIVVRAVEVAHAVAEALRIIDDYEPPPRPYVELPPRPAAGCAATEAPRGLLYHRYAMDADGALTQARIVPPTAQNQAAIEEDLRRVVQTRLDRPGAAATDEELTALCERAIRNHDPCISCSAHFLDLTVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH6</accession>
    <name>A0A1E7NFH6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7548"/>
    <dbReference type="EnsemblBacteria" id="OEV39437">
        <property type="protein sequence ID" value="OEV39437"/>
        <property type="gene ID" value="HS99_0001680"/>
    </dbReference>
    <dbReference type="OMA" id="GHVNMAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="20"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34084" checksum="0E6255548FC40976" modified="2017-01-18" version="1">MDSMSGLSTTPPVLTLTMNPTVDICCDVDHLVDIGKTRARVRYVAAGGGGINVARGVARFGGRATAVHTAGQEIGQRLNRLLDEEGIDHLALGIAGETREAFVLFETESHRSYHIVPRGPRLDDDEGRRCLDLIERAAGTHPYVVASGSLPEGLLDDFYTAVARRIRGTGSRLLLDTSGPALPESLHEAVYLRRCNRSEASYLVGRAVQSFDDARAVNEQLLAAGAAEVAITTLGELGALCSTGQGHMELHAPPLPGEPLSDAGAGDGMIAAIVTRLAEGDDPVDACALGVAAAAASMLTPGTEPFDREVAESLCPAVRISRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFV0</accession>
    <name>A0A1E7NFV0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0001300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367017.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1549"/>
    <dbReference type="EnsemblBacteria" id="OEV39373">
        <property type="protein sequence ID" value="OEV39373"/>
        <property type="gene ID" value="HS99_0001300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003539">
        <property type="entry name" value="CD_toxinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01388">
        <property type="entry name" value="CDTOXINB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="823"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1050" mass="112240" checksum="A2AC09F460734A6F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG04</accession>
    <name>A0A1E7NG04_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">araA</name>
        <name evidence="8" type="ORF">HS99_0002935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279255.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2781"/>
    <dbReference type="EnsemblBacteria" id="OEV39641">
        <property type="protein sequence ID" value="OEV39641"/>
        <property type="gene ID" value="HS99_0002935"/>
    </dbReference>
    <dbReference type="OMA" id="HMLEICP"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="364"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="502" mass="54824" checksum="E08F2FF615BB5D16" modified="2017-01-18" version="1">MKKPLDGRQVWFLTGSQGLYGEQTLRQVAEQSQRIAAALDGDPAMPVEVVWKPVLTDASAIRRICLEANSADDCIGLIAWMHTFSPAKMWIAGLDALQKPLLHLHTQANIELPWDSIDMDFMNLNQAAHGDREFGYIQSRLGVARKTVAGHVSDPTVAARVATWARAAAGRAELRGLRLARFGDNMRDVAVTEGDKVEAQRRFGVSVNTYGVNDLVAAVDAADDGDVTALVKEYEDTYRLVPELRAGGERHDSLRYAARIELGLRGFLEQGGFKAFTTNFEDLGGLRQLPGLAVQRLMADGYGFGGEGDWKTATLLRTLKVTSGGLAGGTSFMEDYTYHLEFGRELILGAHMLEVCPSIAADTPSCEIHPLSIGGREDPVRLVFDAEPGPAVVVGLADLGDRFRLVANEVDVVAPPAPLPHLPVARAVWEPRPDLHTSTEAWLTAGGPHHTVLSRAVGAEELDDLAEMLGVELLLIDEETSLRRFTKELRWNQAYHRLAQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG13</accession>
    <name>A0A1E7NG13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285767.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6725"/>
    <dbReference type="EnsemblBacteria" id="OEV39565">
        <property type="protein sequence ID" value="OEV39565"/>
        <property type="gene ID" value="HS99_0002480"/>
    </dbReference>
    <dbReference type="OMA" id="VKWMEAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="52"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="220"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="481"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="571" mass="60570" checksum="B73B5E4FC9EA26FC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB3</accession>
    <name>A0A1E7NGB3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386208.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2930"/>
    <dbReference type="EnsemblBacteria" id="OEV39759">
        <property type="protein sequence ID" value="OEV39759"/>
        <property type="gene ID" value="HS99_0003665"/>
    </dbReference>
    <dbReference type="OMA" id="MLLLCND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010037">
        <property type="entry name" value="FkbH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01686">
        <property type="entry name" value="FkbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="41926" checksum="899E2170F031FF14" modified="2017-01-18" version="1">MTSEGTAGRPDGTTADRPARTVKCVVWDLDHTVWDGILLEDGEAPLRPGLREVIVELDRRGILHSIASRNDHDAATAALRRHGLLDYFLYPQINWNAKSSSIRSIATSLNLGLDAFAFVDDDVFERGEVSFEIPELLVLDAAEAAGLADRPEFSPRFITDDSARRREMYLADQERTRVEKEFTGPQEAFLATLGMTLTIHPAQEEDLRRAEELTVRTHQLNTTGYTYSYDELDAFRRSDTHELLVARLEDRHGPYGTIGLVLLAKDPDAWTVKLLLMSCRVMSRGVGGVIINHLRRRAREAGVRLLAEYLPNGRNRMMLITYKFTGFHQLTGADGLTLFEADLTDVPGDPQYLTVRTPSVHAPTAGAPTGEDRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF9</accession>
    <name>A0A1E7NGF9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387026.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000628.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2868"/>
    <dbReference type="EnsemblBacteria" id="OEV39715">
        <property type="protein sequence ID" value="OEV39715"/>
        <property type="gene ID" value="HS99_0003375"/>
    </dbReference>
    <dbReference type="OMA" id="TWPPEPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="24969" checksum="E54782B9BA93CA3F" modified="2017-01-18" version="1">MRPIEGRRPAPVTRQDPAVIWRNRALRLMDHVPLPIAVCEYGGRILIVNRAMAAEFGLLPGQLRHRRILEFFTLHDRATLQALTEAVRLHRRSQYPARVSWTPADGRERQGEMTVELISDSAEETPNLLISLRTLAEPAAPSVPRQPGPGAEVSPIEARILAAAARGATTARIAKEVGLTADGVNYHLSRLSRRWHLPNRTALVARAYALGVLAAGTWPPEPARPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV12</accession>
    <name>A0A1E7MV12_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0016250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550557.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2972"/>
    <dbReference type="EnsemblBacteria" id="OEV32266">
        <property type="protein sequence ID" value="OEV32266"/>
        <property type="gene ID" value="HS99_0016250"/>
    </dbReference>
    <dbReference type="OMA" id="PLGSEHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198452" description="Microbial collagenase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="14">
        <location>
            <begin position="686"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="858" mass="90852" checksum="764B23A554BC7204" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV21</accession>
    <name>A0A1E7MV21_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynS</name>
        <name evidence="5" type="ORF">HS99_0016290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + 3 H(+) + hydrogencarbonate = 2 CO2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279662.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000906.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2980"/>
    <dbReference type="EnsemblBacteria" id="OEV32274">
        <property type="protein sequence ID" value="OEV32274"/>
        <property type="gene ID" value="HS99_0016290"/>
    </dbReference>
    <dbReference type="OMA" id="YELVMIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009439">
        <property type="term" value="P:cyanate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="PTHR34186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="SSF55234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate_lyase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16591" checksum="4FEFA9FA2D22F348" modified="2017-01-18" version="1">MVHAQFDPTARQALAVAAVDAKTRKDLSWQQIADASGLSVAFTTAAVLGQHALPEDSAKAVAALLGLDDDAALLLQTIPTRGSIPGGIPTDPTIYRFYEMLQVYGTTLKALVHEQFGDGIISAINFKLDVKKVADPEGGERAVITLDGKYLPTKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV25</accession>
    <name>A0A1E7MV25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000906.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2981"/>
    <dbReference type="EnsemblBacteria" id="OEV32275">
        <property type="protein sequence ID" value="OEV32275"/>
        <property type="gene ID" value="HS99_0016295"/>
    </dbReference>
    <dbReference type="OMA" id="CLGSLYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18895" checksum="9A0D607383A413D5" modified="2017-01-18" version="1">MDFVQRTIDLARRNVTEGGRPFATVIVKDGRILAESANKVAQTNDPTAHAEILAIREACTKLGTEHLTGTTIYVLAHPCPMCLGSLYYCSPDEVVFLTTRDAYEPHYVDDRKYFELANFYDEFAKNWEERRLPMRYSPSEDAVEVYRLWQQRNGGERRVAGTPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV38</accession>
    <name>A0A1E7MV38_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367082.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32294">
        <property type="protein sequence ID" value="OEV32294"/>
        <property type="gene ID" value="HS99_0016415"/>
    </dbReference>
    <dbReference type="OMA" id="LAMWLAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="221" mass="22965" checksum="AD26CCAA0021BBE9" modified="2017-01-18" version="1">MGAIVFNVTTAALMVMMVNCGLGVVGRDTLRGRPLPWAAIALTVVAVGGVVLQLVWSGAMDALDGDPAKSGWWREFTSVFMQNGGLFGDLWNLVTLAAVAALAQWYWGGALTLVLFLLGIVLPGRIDGLLGLGDGPSTDPRNFAGSSGATYFLGATLALALLTRTRVPKEIALAAGVPVLGLAMWLAQDNGHGLVSVYGFALAAAVRVVRSRLVRSTGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVR1</accession>
    <name>A0A1E7MVR1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0016775</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6943"/>
    <dbReference type="EnsemblBacteria" id="OEV32353">
        <property type="protein sequence ID" value="OEV32353"/>
        <property type="gene ID" value="HS99_0016775"/>
    </dbReference>
    <dbReference type="OMA" id="LKHTQWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="588" mass="64349" checksum="FC780619112099FD" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWD3</accession>
    <name>A0A1E7MWD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7826"/>
    <dbReference type="EnsemblBacteria" id="ARF78218">
        <property type="protein sequence ID" value="ARF78218"/>
        <property type="gene ID" value="B6264_04175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32740">
        <property type="protein sequence ID" value="OEV32740"/>
        <property type="gene ID" value="HS99_0015910"/>
    </dbReference>
    <dbReference type="OMA" id="TVSERHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="21113" checksum="29171865758F22F6" modified="2017-01-18" version="1">MDMTPVAPVPTVAPSPGSRQRLWLTLGAFGFAAFIALALAFAHDTASLGAYRYNPPEEFLGLPRLPAGQIPKASTVARGVKVTGYQTSDRSRTVAVTVRELPIVSPSATVDTVITESTTGLHVESVRTVDPGERGGVMKCGHTSGMKKAGKPQDMAFCVWADGSMWAVYGEHGDDVTLDTDDLANDARKFRHLAEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWP1</accession>
    <name>A0A1E7MWP1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000084">
        <property type="protein sequence ID" value="OEV32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367184.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000084.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2555"/>
    <dbReference type="EnsemblBacteria" id="OEV32834">
        <property type="protein sequence ID" value="OEV32834"/>
        <property type="gene ID" value="HS99_0039950"/>
    </dbReference>
    <dbReference type="OMA" id="CDAWFGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="23397" checksum="31E2953F3FBC1582" modified="2017-01-18" version="1">MRAVLAAPTPTLLVIAKSPVPGRVKTRLTPPCTPEQAATLAGAALEDTLATLSRVPAGRRLLVLDGEPGGWLPPGWEVVPQCTGGLDERLAAAFARAARVAPRAPALLVGMDTPQLDAAALAEPLSAARRPGVDAWYGPAADGGFWALGLARPTGRLARRLLLGVPMSTPDTGRALLARLAAAGLTVHHLDLATDVDTIAAARRVAAEAPQTTFAACLRSIDAAPGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR2</accession>
    <name>A0A1E7MWR2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0039775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557191.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene73"/>
    <dbReference type="EnsemblBacteria" id="ARF80131">
        <property type="protein sequence ID" value="ARF80131"/>
        <property type="gene ID" value="B6264_15460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32868">
        <property type="protein sequence ID" value="OEV32868"/>
        <property type="gene ID" value="HS99_0039775"/>
    </dbReference>
    <dbReference type="OMA" id="WMLTGGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="33251" checksum="DF2B3CB93DE230C0" modified="2017-01-18" version="1">MSDLVTGEAVVLDLQTAKLPSRALAIVLDLLVEFAALFICTLVMSVALADLDSAALTATMLGMTVFFLVALPVMVETLTHGRSLGKAALGLRVVRTDGGPVRFRHSLVRGLVGFFEVIAITGAPAVITSALNPDGKRLGDIFAGTVVIRERTPGVGGPASPLPPVHPQLLHAMGRELVAMDLSAVPEPLWLATRQLLGRIGQLDPSVTFRMSTGLAGDLAARTGNPVPQGLHPAAYLGAVITERQRREWMRAHQQFAAAAVPVQTPAPHPVATPDGRPHRVLGGPAAPVPAPAPAAPSFTKPAAPAQPTPPAPGTGFAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX12</accession>
    <name>A0A1E7MX12_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5739"/>
    <dbReference type="EnsemblBacteria" id="ARF81384">
        <property type="protein sequence ID" value="ARF81384"/>
        <property type="gene ID" value="B6264_22935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32970">
        <property type="protein sequence ID" value="OEV32970"/>
        <property type="gene ID" value="HS99_0013905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="22539" checksum="CFB9D72079A1A456" modified="2017-01-18" version="1">MAAMNTTEINASPAPALTIGFDLDMTLADGRPGIKAVLDMVAAETGVAIDSDLAITRVGPPIEEEMAYWFPADQVDAAADRYRALFPEHGAPVGKLLPGALEAIAAVYRHGGRPIVVTGKFEPNARLNLAALDIKVDDVFGSVFADRKGSVLREQGASVYVGDHLGDITGARTGGALAVAVATGPYTADELREAGADVVLNDLTEFPGWLDTHLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX91</accession>
    <name>A0A1E7MX91_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279752.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5634"/>
    <dbReference type="EnsemblBacteria" id="ARF81474">
        <property type="protein sequence ID" value="ARF81474"/>
        <property type="gene ID" value="B6264_23460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33058">
        <property type="protein sequence ID" value="OEV33058"/>
        <property type="gene ID" value="HS99_0014430"/>
    </dbReference>
    <dbReference type="OMA" id="CIREHET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16408" checksum="1F0C26ECC6A91F64" modified="2017-01-18" version="1">MTRASDIMHQGAECIREHETLAAAARIMRERHVGALPICGEDDKLLGIVTDRDIVLRCVAEGGDPAEMTAGDLALGRPMTVEADEDCEQVLRVMEQYQVRRLPVISHPEHKLVGMISEADIARGLPQARLAEFVTAVCAEEPPKKEALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXD9</accession>
    <name>A0A1E7MXD9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2706"/>
    <dbReference type="EnsemblBacteria" id="OEV33108">
        <property type="protein sequence ID" value="OEV33108"/>
        <property type="gene ID" value="HS99_0014745"/>
    </dbReference>
    <dbReference type="OMA" id="HDGHAIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13737" checksum="1EC30C90E20E2666" modified="2017-01-18" version="1">MTITLERTETAATVGDLMTCPELQVSDDVMVDMAMDILQSSGVDHLLVRDDDGRCAGLLTRLHLAPFQARSWYTERTPVRDIVLDRAPFATADMPADAAAAAMRARGLDVWPVVDHDGHAIGLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE1</accession>
    <name>A0A1E7MXE1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock domain protein CspD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0014735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_035850027.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3416"/>
    <dbReference type="EnsemblBacteria" id="OEV33106">
        <property type="protein sequence ID" value="OEV33106"/>
        <property type="gene ID" value="HS99_0014735"/>
    </dbReference>
    <dbReference type="OMA" id="IMGLVKW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="67" mass="7359" checksum="FA1880A0F5F0BB8C" modified="2017-01-18" version="1">MANGTVKWFNAEKGFGFIEQEGGGADVFAHYSNINANGFRELLEGQKVEFDVTQGQKGPQAENIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXU6</accession>
    <name>A0A1E7MXU6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0038930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000069">
        <property type="protein sequence ID" value="OEV33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000861.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000083_gene4503"/>
    <dbReference type="EnsemblBacteria" id="ARF82880">
        <property type="protein sequence ID" value="ARF82880"/>
        <property type="gene ID" value="B6264_17150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33268">
        <property type="protein sequence ID" value="OEV33268"/>
        <property type="gene ID" value="HS99_0038930"/>
    </dbReference>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="48999" checksum="7D70B240D5B4851F" modified="2017-01-18" version="1">MSDKADPNPYTLRPAEGDTGDALRDVELELSKRWPENKLEPSLDRIEALMDILGQPQRAFPSIHITGTNGKTSTARMIEQLLNTFELRTGRYTSPHVETVTERISLDGAPISPERFVEVYRDIEPYVQMVDAAQPVPMSFFEVLTGMAYAAFADAPVDVAVVEVGMGGSWDATNVIDAAVAVITPIGLDHTDKLGETTGAIAVEKSGIIKSGAVAVVAQQQLDAAETILRRAVEVDATVAREGMEFGVIRRELAVGGQLVTLRGLGGEEYEDVFIPLHGEHQAHNAALALAAVEAFFGVGGARGGQLDADKVRQGFSGVSSPGRLEVVRRSPTIILDAAHNPHGARATVAAISESFGFTRLVGVIGTSGDKDVAGVLEAFEPILAEVVVTRNSTHRAMDVDALAALAVEVFGEDRVQVEPRLDDAIAAAVTLAEEEGDLGGAGVLVTGSVITVGEARLLLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXY7</accession>
    <name>A0A1E7MXY7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0038800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290011.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3283"/>
    <dbReference type="EnsemblBacteria" id="ARF82870">
        <property type="protein sequence ID" value="ARF82870"/>
        <property type="gene ID" value="B6264_16505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33308">
        <property type="protein sequence ID" value="OEV33308"/>
        <property type="gene ID" value="HS99_0038800"/>
    </dbReference>
    <dbReference type="OMA" id="FGGCPMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="318" mass="33562" checksum="143DC8111D2578DC" modified="2017-01-18" version="1">MDLGLPDPVRAPGLPEEVRIHEVGPRDGLQNEGSLVPVEVKAEFIGRLAAVGLRTVEATSFVHPKWVPQLADAEELMPRLADLPGRHPGLRLPVLVPNERGLDRALAHHATDIAVFASATETFARRNLNRSADEAMEMFRPVVTRAAEAGIAVRGYLSMCFGDPWEGPVPVDQVVSFGVQLLEMGCAELSLGDTIGVATPGQVRALLAGFARAGVPVARLAVHFHDTYGQALSNTLAALREGVTTVDASAGGLGGCPYAKSATGNLATEDLVWMLHGLGVRTGVDLRALVATSGWMAERLGRPSPSRTVQALLGASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY12</accession>
    <name>A0A1E7MY12_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0038755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3274"/>
    <dbReference type="EnsemblBacteria" id="OEV33304">
        <property type="protein sequence ID" value="OEV33304"/>
        <property type="gene ID" value="HS99_0038755"/>
    </dbReference>
    <dbReference type="OMA" id="LGHYFGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="37788" checksum="FC0FA8353CA37B04" modified="2017-01-18" version="1">MLSAEPSAVPVLTAADLIADPGAHRVLTGDRPTGPLHLGHYFGTLQNRVRLQDQGVEMFVLVADYQVITDRDLADRLAEHTENLVLDYLAAGLDPERATIFAHSAVPALNQLLLPFLSLVSVAELSRNPTVKDEIAHSSQAAVNGLMFTYPVHQAADILFCKADLVPVGQDQLPHLEVARTVARRFNERYPHADGSAVFPRPRALLSEAPMLLGTDGGKMSKSRGNAVALGADEDETARIIRGARTDADRRITYDPTGRPGVSGLLLLAALCQDRAPETIAEEIGDGGAAVLKRTVIESVNEYFRPLRVRRAELATDRGHLRQVLRAGAERANAIADATLAEVREVMGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY81</accession>
    <name>A0A1E7MY81_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">DNA primase</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name evidence="4" type="ORF">HS99_0012470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2 3">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553442.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3993"/>
    <dbReference type="EnsemblBacteria" id="ARF80499">
        <property type="protein sequence ID" value="ARF80499"/>
        <property type="gene ID" value="B6264_17695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33397">
        <property type="protein sequence ID" value="OEV33397"/>
        <property type="gene ID" value="HS99_0012470"/>
    </dbReference>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0639">Primosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 2 3" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="CHC2-type" evidence="1 3">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="638" mass="70263" checksum="84535F423FE509D2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYG4</accession>
    <name>A0A1E7MYG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555539.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000465.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6603"/>
    <dbReference type="EnsemblBacteria" id="ARF80567">
        <property type="protein sequence ID" value="ARF80567"/>
        <property type="gene ID" value="B6264_18110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33464">
        <property type="protein sequence ID" value="OEV33464"/>
        <property type="gene ID" value="HS99_0012890"/>
    </dbReference>
    <dbReference type="OMA" id="HVLSHRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22634" checksum="EE40F0202DD7AD62" modified="2017-01-18" version="1">MAYRRTPAVQARLDAQREAVLQSAVGLLAERGYGGCTMAAVADRAGIATGSLYQHFANKAELSVELFRRVVTREIAAVNAAVARRDAPQQRIAAVVETFAARALRAPRLAYALLVEPADAVVDGERLVFRRAFRDVIATEIAAAVAAGELPEQDPVLTAAALVGAVGEALAGPLAAEPAPAPAHEPAPAPAHSDNTTVVPALVSFTLRALGGRDDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYK4</accession>
    <name>A0A1E7MYK4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0013310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385710.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5210"/>
    <dbReference type="EnsemblBacteria" id="OEV33530">
        <property type="protein sequence ID" value="OEV33530"/>
        <property type="gene ID" value="HS99_0013310"/>
    </dbReference>
    <dbReference type="OMA" id="NTNHGEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="113"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="37866" checksum="E7D2FEEB9FC4B413" modified="2017-01-18" version="1">MTSSTDSAAARARRIVALNTAYFQAKALQSAVELGLFELLAERSAGLDQIRAELGVRHRLFKDFLNALVGLGLLDEQDGGYRASELAREFLLPGPTYLGGTARQHARLHYHAWAQLTDALRDGKAKSAVAAQGQLAYPKQYEDLDRARQIMLHMDAHNGFTADELARAIDWSRYTSFVDVGGGRGNVASRIVTAHPHLRGGVFDLPALRPLFEELVASAGTADRVDFHGGDFFATDLPEADVVIFGHVLPDWPVGDRRELLRRAHKAVRPGGLVVLYDAMIDPEERDPEVLLQRINHTMIRDEAGAYSLQEARAYLEEAGFTVDRIAASDTITRDHFAIGVKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYQ2</accession>
    <name>A0A1E7MYQ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000877.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5256"/>
    <dbReference type="EnsemblBacteria" id="ARF80675">
        <property type="protein sequence ID" value="ARF80675"/>
        <property type="gene ID" value="B6264_18755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33570">
        <property type="protein sequence ID" value="OEV33570"/>
        <property type="gene ID" value="HS99_0013535"/>
    </dbReference>
    <dbReference type="OMA" id="GALPHMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26674" checksum="9CD49DB816C8F20C" modified="2017-01-18" version="1">MDTSTARPLDGRTALVTGAASGIGRACAETLAGAGARVYVVDLAAVPARELADRIGGHAIVADLADPEAVDALPADADIVVNNAGLQHVAPVHEFPVDRFTLIQRVMVEAPFRILRRTLPHMYGRGWGRVVNVSSVHGLRASAFKSAYVTAKHALEGLSKTVALEGAPYGVTSNCLNPGYVRTPLVEKQIAAQALAHGIPEDEVVEQIMLDRTAVKRLIEPAEVAQLALWLCTPPAAYITGASLPIDGGWTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYT1</accession>
    <name>A0A1E7MYT1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0012215</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553484.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4045"/>
    <dbReference type="EnsemblBacteria" id="ARF82885">
        <property type="protein sequence ID" value="ARF82885"/>
        <property type="gene ID" value="B6264_17445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33579">
        <property type="protein sequence ID" value="OEV33579"/>
        <property type="gene ID" value="HS99_0012215"/>
    </dbReference>
    <dbReference type="OMA" id="YLHVPDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116863" checksum="27721C91D68B5C58" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ15</accession>
    <name>A0A1E7MZ15_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">HS99_0038480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280932.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000811.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4943"/>
    <dbReference type="EnsemblBacteria" id="ARF80011">
        <property type="protein sequence ID" value="ARF80011"/>
        <property type="gene ID" value="B6264_14810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33674">
        <property type="protein sequence ID" value="OEV33674"/>
        <property type="gene ID" value="HS99_0038480"/>
    </dbReference>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="346" mass="37922" checksum="5853D8DF077BAB64" modified="2017-01-18" version="1">MVNAAVTGPVKDRPRVLSGIQPTSGSFHLGNYLGAVRQWVDLQKENDAFYMVVDLHAITVPQDPATLRQNTRISAAQLLGAGLDPEHCTLFVQSHVPEHAQLAWVMNCLTGFGEASRMTQFKDKSSRYGADSTTVGLFTYPILQIADILLYQADAVPVGEDQRQHVEITRDIAERFNSRYAPVFTIPKPYILKETAKIMDLQDPGIKMSKSASSPKGLVSLLDEAKVSAKKFKSAVTDTGTVVSYDEEQKPGVSNLLRIHSALSGQSVEQLVAHFEGKMYGALKTELAELFAEWVTPFQQRTGAFLDDPAELDRVLAIGAEKARAVASETLATVYDRIGFLPAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ83</accession>
    <name>A0A1E7MZ83_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="2" type="ORF">HS99_0037990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386901.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7709"/>
    <dbReference type="EnsemblBacteria" id="ARF78575">
        <property type="protein sequence ID" value="ARF78575"/>
        <property type="gene ID" value="B6264_06285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33737">
        <property type="protein sequence ID" value="OEV33737"/>
        <property type="gene ID" value="HS99_0037990"/>
    </dbReference>
    <dbReference type="OMA" id="RCDIDTP"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="22592" checksum="3DB872805E60E1B7" modified="2017-01-18" version="1">MTQDTVRPSGPVAPAAPATDWSLVLPLKPLALAKSRLAPYAGPHRAGLALSFALDTVTAALATPGVARVLVVTRDAAAGARLAALGAVVVADEPGGGLNRALSHGASAALALAPRAPLAALSADLPALRPAELARVLRAVPPDGRAFLPDSPGLGTTLLASAPGRPLSPAFGDGSRARHAAGGALELRLAGVESVRRDVDTGTDLGEAAALGLGPYTSALFARMSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC8</accession>
    <name>A0A1E7MZC8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0037760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289095.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3787"/>
    <dbReference type="EnsemblBacteria" id="OEV33788">
        <property type="protein sequence ID" value="OEV33788"/>
        <property type="gene ID" value="HS99_0037760"/>
    </dbReference>
    <dbReference type="OMA" id="STWYLVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="344" mass="36814" checksum="2AB24E9B707EE763" modified="2017-01-18" version="1">MLLGMKRDRTATFFILLFPLVFLVFFGSVTKGSSTPHAKVAQVGAVKLFDSMTGEGRSELDKVLTITRTDDEAGTLEKVRKGDFDAMITQGADGKVELRYTAADQVRAGALQGIFNSVVQEANQQATHQAPAYVVDAQQVEDKSLKPIQFLTPGLLGWAVATGAVFGAALTLVNWRKTKVLRRLRLAPISAGTVVSSRILVSLLTAFLQTGVFLVVATSFFGLKLTGNWWLVLPLVACATLAFMSIGLLAGSVARTEEAANGISQVIVLPMSFLSGSFFPMDGAPGWLQTVSKVMPLHYLVDSAQSVLTRGGGVTDALPTMGGLLLFAAVLTGIAWKLFRWEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK2</accession>
    <name>A0A1E7MZK2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551278.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000751.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6355"/>
    <dbReference type="EnsemblBacteria" id="ARF78769">
        <property type="protein sequence ID" value="ARF78769"/>
        <property type="gene ID" value="B6264_07420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33856">
        <property type="protein sequence ID" value="OEV33856"/>
        <property type="gene ID" value="HS99_0037225"/>
    </dbReference>
    <dbReference type="OMA" id="WRGNIAP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="44349" checksum="F375EA03188A7C44" modified="2017-01-18" version="1">MKRPAIFVLPTLVLGITVVVPMVWGDHPIRFEHRRPTEVHWAGAPTEQGRVWGFGKDAPPAPADTGPKVARPWTKGSPEWGVQVYWLDDPADPDSYVQGKVDRIVKYVVGLNANSLSVTFPYYTTGTKSNAVAARPTSPSPERLALLLDAAHRAGLRTTVRPIMDEEVFDYVHTLKWRGNIAPTDRDAWFASYAAFLAPYLKTAQDHSAAEFTIGTEFNSLEGDPHWQGLIDEARKAFHGELEYDANFDNWSKGAIAVPADGTGADAYPPARNADDDAPIADLKASWNAWLDHRGKGPQPTTKLTEVGIPAQNGAYRTPGEYYKKTELNETVQATWFTAVCQVAQERKLRGLYFWSLYFGIDPTLPTTPDTPRMDYAGRPNSEKAIRDCFAQTYEVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK4</accession>
    <name>A0A1E7MZK4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282181.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6376"/>
    <dbReference type="EnsemblBacteria" id="ARF78751">
        <property type="protein sequence ID" value="ARF78751"/>
        <property type="gene ID" value="B6264_07315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33872">
        <property type="protein sequence ID" value="OEV33872"/>
        <property type="gene ID" value="HS99_0037330"/>
    </dbReference>
    <dbReference type="OMA" id="MIQAWDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="14146" checksum="08475F5AA0BC6C9D" modified="2017-01-18" version="1">MSTMAAPAAFDTRALREGIERCDAEALLALYAEDAELRVVDRKTQPSHPLVMHGRDEIGAMLDDVYSREMTHKLEQVVVEGDHLAFLESCHYPDGVRVLMASMANLRDGRIVDQTSVQAWDESGSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP4</accession>
    <name>A0A1E7MZP4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0010450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385912.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000162.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1828"/>
    <dbReference type="EnsemblBacteria" id="ARF77738">
        <property type="protein sequence ID" value="ARF77738"/>
        <property type="gene ID" value="B6264_01290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33895">
        <property type="protein sequence ID" value="OEV33895"/>
        <property type="gene ID" value="HS99_0010450"/>
    </dbReference>
    <dbReference type="OMA" id="WQHRHGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16023" checksum="7AD7D2873AD5515D" modified="2017-01-18" version="1">MADNNHSTSAGSTGSFQSTTLEITTGNREVALDITDRCVAFLNERAPGRDGLLNVFVPHATAGIAVLETGSGSDDDFLAVLRDLLPADDRWRHRHGSPGHGRDHVVPGLVAPHATLPVLGGQLALGVWQSVVLIDTNGDNPRRTVRLSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N024</accession>
    <name>A0A1E7N024_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0011340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551794.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2279"/>
    <dbReference type="EnsemblBacteria" id="ARF77890">
        <property type="protein sequence ID" value="ARF77890"/>
        <property type="gene ID" value="B6264_02190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34032">
        <property type="protein sequence ID" value="OEV34032"/>
        <property type="gene ID" value="HS99_0011340"/>
    </dbReference>
    <dbReference type="OMA" id="KYIMALE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="34405" checksum="655A02B2036E230F" modified="2017-01-18" version="1">MIDVQRLAVLREVSRRGSFNQAALALHCTPSAVSQQVAALERGLGAPVVERSTRGVTLTDTGRLLVEAADAIAAELTDTQQRIARLTAERTTLTVATFASGGRRLLPAALARFAAEHPEVELTILEAEPEESLPAVREGRADLALAYHLEGPPPARPGDRSGLDWTRLGEDPLRVVLPRHHPAAARYRSRPEAPHLAELADQRWILGCRKSADQLARYADLAGVELRISCTATDYEFAQSLVRAGIGIALIPEIGLARHPELVALPLAEPSPRRYLGLALARRRRGRVARLAEELASRLAGGAEEEAKAAPGSDGSGPTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H3</accession>
    <name>A0A1E7N0H3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0011465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388040.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2303"/>
    <dbReference type="EnsemblBacteria" id="OEV34171">
        <property type="protein sequence ID" value="OEV34171"/>
        <property type="gene ID" value="HS99_0011465"/>
    </dbReference>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="542"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1027" mass="109527" checksum="66232E9682A868E7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R7</accession>
    <name>A0A1E7N0R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290918.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000090_gene1895"/>
    <dbReference type="EnsemblBacteria" id="ARF78501">
        <property type="protein sequence ID" value="ARF78501"/>
        <property type="gene ID" value="B6264_05850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34290">
        <property type="protein sequence ID" value="OEV34290"/>
        <property type="gene ID" value="HS99_0036530"/>
    </dbReference>
    <dbReference type="OMA" id="NWTAAMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="28696" checksum="D690646BA2AFBA37" modified="2017-01-18" version="1">MTIGKSSDRDNAPSSVEPTDDAEQAADAPSIGRVLSAARIEAGLTVDQVSTSTRVRVPIVHAIEEDDFGRCGGDFYARGHIRSIAQAVGADAEALVARFDEAHGGSPASKRPTTQLIDSGPIKVPARSRPNWAAAMVAAIVAVVGLIGFNLVSGRGGHTGTGTGSASAPLPSGSSTGSVAPVTPTVQPSAPAAIAAVPADKVTVKLVAEGTSWVSAMDGNGKSLFQNNMSGGQDQTFTDPKQIKLVLGNGGAVHAYVNGKDLGVLGKDGQVVHVTYTPGDPQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N145</accession>
    <name>A0A1E7N145_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557821.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7208"/>
    <dbReference type="EnsemblBacteria" id="ARF79223">
        <property type="protein sequence ID" value="ARF79223"/>
        <property type="gene ID" value="B6264_10125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34404">
        <property type="protein sequence ID" value="OEV34404"/>
        <property type="gene ID" value="HS99_0035945"/>
    </dbReference>
    <dbReference type="OMA" id="LAEHDPF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008024">
        <property type="entry name" value="YiaAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05360">
        <property type="entry name" value="YiaAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="96" mass="10355" checksum="51F50720D555DF51" modified="2017-01-18" version="1">MNAPMQSRTTAAYHVQAILSFAISGTALAAGIAYLPVGGWTRAFLGIGLLYTVTSSFTLAKVIRDRQESSDTVARVDQARLEKLLSEHDPFKVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N210</accession>
    <name>A0A1E7N210_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555873.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81898">
        <property type="protein sequence ID" value="ARF81898"/>
        <property type="gene ID" value="B6264_26110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34740">
        <property type="protein sequence ID" value="OEV34740"/>
        <property type="gene ID" value="HS99_0009660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="15427" checksum="E14198D6F37F32C0" modified="2017-01-18" version="1">MKTHRTAGLRARTAPAVLAVAAVLAVGAAGCDSAPSEQLPATEADPSSSAPAGPPDFTLFTGTWGGHGNQMTVNADGSFTMEMRTGRSGPSDSSASGRIDSVSGTVAKGAITTTGDHLAMPVGPLTFVYDSANNAINALRINWCGPKAPVGVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2F6</accession>
    <name>A0A1E7N2F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34874">
        <property type="protein sequence ID" value="OEV34874"/>
        <property type="gene ID" value="HS99_0009125"/>
    </dbReference>
    <dbReference type="OMA" id="ELWLDHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="12040" checksum="FB6E3E2D10938702" modified="2017-01-18" version="1">MAAPAPVVLGIDDLRSLPRATRIARTSREGIQLLQEHRDSFIDELWLDHDLGGDDTIMPVVTLMEEAAFNGRPFQIGTVFVHSANPIGAETVVRSLTRWNYQVRRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2N9</accession>
    <name>A0A1E7N2N9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name evidence="2" type="ORF">HS99_0034660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287982.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7674"/>
    <dbReference type="EnsemblBacteria" id="ARF78539">
        <property type="protein sequence ID" value="ARF78539"/>
        <property type="gene ID" value="B6264_06100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34961">
        <property type="protein sequence ID" value="OEV34961"/>
        <property type="gene ID" value="HS99_0034660"/>
    </dbReference>
    <dbReference type="OMA" id="FDRALYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15500" checksum="89ACE917D2F277CB" modified="2017-01-18" version="1">MAVKIKLKRLGKIRSPHYRIVVADARTKRDGRAIEEIGIYQPTYNPSKIEVDSDRAQYWLSVGAQPTEPVLAILKLTGDWQKFKGLPAPEPLKVAEPKVEDFSHLFAKAVAGFEDATTGVAITPKAKKSDKAEADADAAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N309</accession>
    <name>A0A1E7N309_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552911.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000130.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35055">
        <property type="protein sequence ID" value="OEV35055"/>
        <property type="gene ID" value="HS99_0034550"/>
    </dbReference>
    <dbReference type="OMA" id="AHEFRTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="12349" checksum="294BF42C0AFE6067" modified="2017-01-18" version="1">MQAFPMNPDRLEGPVLLLDDAGAAWQLRKKRVDLRAVRRLMKDPASVVVLGESGGTRPRLVVDGERPMLWGMVKDDYKGSGGSRTAGRYLAHEFRTHADRRMLYLEEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N335</accession>
    <name>A0A1E7N335_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0034245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286597.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene375"/>
    <dbReference type="EnsemblBacteria" id="ARF78922">
        <property type="protein sequence ID" value="ARF78922"/>
        <property type="gene ID" value="B6264_08335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35119">
        <property type="protein sequence ID" value="OEV35119"/>
        <property type="gene ID" value="HS99_0034245"/>
    </dbReference>
    <dbReference type="OMA" id="NWGLMRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="30585" checksum="830B7ED6D26A838E" modified="2017-01-18" version="1">MSTGTATEHAVGGAVPTPRRGLSATLHDSWVVAKRNLRRMSRIPEIVVFGLMQPVMFVLLFSYVMGGAIKIPGANSSSDTYIQFLMAGIFAQTVTFATAGASAGIAEDMTKGLVDRFRSLPMARSAVLVGRTLADLCQTAFTVVVLALVALAVGWRVHDGVLSALGAFGLLLLLGYAFSWIGALIGLSVRSPEAATSAGLIWLFPLTFVSNAFVPVSSMPGWLQGVAYWNPFSATVQACRDLFGNQVGPVDNTWPMQHAALVSVLWSLVITAVFSWLSVRKYRSAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3A2</accession>
    <name>A0A1E7N3A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288629.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5892"/>
    <dbReference type="EnsemblBacteria" id="ARF82059">
        <property type="protein sequence ID" value="ARF82059"/>
        <property type="gene ID" value="B6264_27090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34933">
        <property type="protein sequence ID" value="OEV34933"/>
        <property type="gene ID" value="HS99_0035075"/>
    </dbReference>
    <dbReference type="OMA" id="ECLWDCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="499" mass="53759" checksum="0DEC94918581B0C2" modified="2017-01-18" version="1">MFEPVIAPSASLLGLLQRGRGDGQLHALAADRAEAIAALEECVTRDPRADWQVESRSLYYARLYMELEASLDGIEDHLHSAEDLVSDDESRTGLALSVLGHLAAYGRRDALLMLREYAATGANWAWALDELALRDDDRGLLLLGTAVLDRFPPGPEGDAELREFIRNAYEPRPWRLWAAYHPRVAAASEQSPFDLWQRQINRSGVTPGWSTADVLAWADQGHLGNLGADAFLGRPEPVRVDEDPSGPDAVDRRAAAAARCLTAVVRPEDRPVLLEAARDGLPGARRAALRYLVDQRDPAALELIEAAAADVDDRIVRAALELLGRMRGPEVLAQARRWADPASGGADSALGETAVRLLADAGEPADAPLVVAGLRRWISVRGVSGTGLGSLVDGAGRLAAADAVPVLRHIYGEAASSELRGRAARALAVTDVHFPEGPAVECLWDCEESTRELAARHVATTGDARVLERLRRLAADPAEEAEVHAAVRGRLTAAREFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I4</accession>
    <name>A0A1E7N3I4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014137253.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000944.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79295">
        <property type="protein sequence ID" value="ARF79295"/>
        <property type="gene ID" value="B6264_10545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35232">
        <property type="protein sequence ID" value="OEV35232"/>
        <property type="gene ID" value="HS99_0033510"/>
    </dbReference>
    <dbReference type="OMA" id="LENSGMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7503" checksum="CB0F7283723C20C8" modified="2017-01-18" version="1">MTARTPDAEPLLTPAEVATMFRVDPKTVTRWAKAGKLTSIRTLGGHRRYREAEVRALLAGIPAQRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P7</accession>
    <name>A0A1E7N3P7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366820.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000364.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5309"/>
    <dbReference type="EnsemblBacteria" id="ARF80720">
        <property type="protein sequence ID" value="ARF80720"/>
        <property type="gene ID" value="B6264_19020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35295">
        <property type="protein sequence ID" value="OEV35295"/>
        <property type="gene ID" value="HS99_0033080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035183">
        <property type="entry name" value="DUF5304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17230">
        <property type="entry name" value="DUF5304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="13980" checksum="E8EEDD7FA1761AFB" modified="2017-01-18" version="1">MTSTDDRTEPGAEQGSGPSHPFGPELGPLVDEVRRFATVVGEKAQETSATTLIALSGLADRLRTQQPEVYSHLAAAGSGLAAAGAELLAAYRAAVAGHEQRWTAGDGAPVEKIDLDEPGRAEDAAAADGADGESAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Y2</accession>
    <name>A0A1E7N3Y2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550092.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3459"/>
    <dbReference type="EnsemblBacteria" id="OEV35396">
        <property type="protein sequence ID" value="OEV35396"/>
        <property type="gene ID" value="HS99_0032840"/>
    </dbReference>
    <dbReference type="OMA" id="RAWHFGP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="22468" checksum="4926CF6B021C6FCB" modified="2017-01-18" version="1">MTDSPTPDDLARTLRLAVDTLAGAPAGADWSRPAGTLGWSCWETVEHLADDLLAYAAQLGPARPPRDRYVPFVATRRSPGAPNNFVRADPADGVAGLLEVLDASGGLMVAVARVAPPDARAYHPWGLADATGFVAMSLVETLVHLHDVSQGLGLAWDPPAEVCARTLARLFPDVPPVDAPWPTLLWATGRTALPGRPPRTDWRWYAEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3Z5</accession>
    <name>A0A1E7N3Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278635.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000871.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2389"/>
    <dbReference type="EnsemblBacteria" id="OEV35410">
        <property type="protein sequence ID" value="OEV35410"/>
        <property type="gene ID" value="HS99_0032750"/>
    </dbReference>
    <dbReference type="OMA" id="PWHPGEA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="76" mass="8982" checksum="DB1F3786FFB93E4F" modified="2017-01-18" version="1">METNSTTAHLIEVAEFRTDSRYRLVHFEGHGWEPLAPEEFEPRIHQLFPGLDPRDPAKVHWADRPWEWPAWHPGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N408</accession>
    <name>A0A1E7N408_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1585"/>
    <dbReference type="EnsemblBacteria" id="OEV35415">
        <property type="protein sequence ID" value="OEV35415"/>
        <property type="gene ID" value="HS99_0032130"/>
    </dbReference>
    <dbReference type="OMA" id="AMIAYED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="143"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="326" mass="34198" checksum="4F5611C3A9B50BF0" modified="2017-01-18" version="1">MLVSGAYFADLVFHGLARPVQPGTEVFADGFGLVPGGAYSLAMALHRLGRRVLWSADFGTDPFSAHVLACARQEGLAEGAFRHHPFPVRSLTVALACADDRAMVSFQDPVDAQPLAPLLGRLRPRVLVLPQLRWDEDTVVGLRAARQLGTLVVMDCHDTPATLDDPAVREALALVDVFTPNDAEALRLTGADGLSGLDGAIAALTALVPTLVITRGAQGAVAVREGERHDAPSVRSGAAIDPTAAGDCFNAGLVHGLLNGWSLPDCLAAATLCGAAATTAPGSSAALDAAELAHQLDRHLDRPLDQDQHRPSRATTNVGRTLHHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N409</accession>
    <name>A0A1E7N409_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290469.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1607"/>
    <dbReference type="EnsemblBacteria" id="OEV35431">
        <property type="protein sequence ID" value="OEV35431"/>
        <property type="gene ID" value="HS99_0032230"/>
    </dbReference>
    <dbReference type="OMA" id="GRTWTIK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198828" description="Ricin B-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="3">
        <location>
            <begin position="704"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="828" mass="85041" checksum="FDFBB5FA81525245" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N449</accession>
    <name>A0A1E7N449_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0032430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553508.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3896"/>
    <dbReference type="EnsemblBacteria" id="OEV35467">
        <property type="protein sequence ID" value="OEV35467"/>
        <property type="gene ID" value="HS99_0032430"/>
    </dbReference>
    <dbReference type="OMA" id="PAVRHGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="217"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="44545" checksum="461AB3D6DB09534D" modified="2017-01-18" version="1">MHVLVVHNRYGSAQPSGENKVVDQEVALLRGAGHRVEVFERRSDDIAARSLPGRAAVPLLVPWNPAVRAELAGRLRAGRPDVVHVHNVFPLLSPAVLAACADAGVPAVATLHNYTQICPPGTLQRDGRPCTECVGGSPLPAVRHGCYRDSRLATVPLAVSLAVNRRRWWSGVERFFCISAAQRDVLVRAGLPPERLAVKHNFVPEPGVGRTGAGEHLLYLGRLAEAKGVRLLMAAWDRLAADGGVGVPLVVAGAGPLEREVAAWAAGRDDVRYAGLYDQARCREAVARSVAVLAPSTWLEAFGLVVVEAMAAGVPVVAAGHGAFVELVEDGVTGLLHRPGEAASLASGIRRIAAEPDRNREMGRAARRRYEQGFGPAVGLERLLEGYRTAIAGRSGGADGAPPVGNTNAGPPRGTRAGGNGGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N489</accession>
    <name>A0A1E7N489_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278188.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5506"/>
    <dbReference type="EnsemblBacteria" id="ARF79400">
        <property type="protein sequence ID" value="ARF79400"/>
        <property type="gene ID" value="B6264_11130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35511">
        <property type="protein sequence ID" value="OEV35511"/>
        <property type="gene ID" value="HS99_0031940"/>
    </dbReference>
    <dbReference type="OMA" id="HVADEQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="278" mass="30642" checksum="D6C5101D5F8F1B75" modified="2017-01-18" version="1">MGTPLGDFIRAKRDSIQPETFGLPDHGRRRSPGLRRSDLAIRAGISVEYLTRMEQGRDRNPSTAVVNALADALSLDPAERTHLRYLAKITGGACPHHVRPTPPSREVRPAVRETLRLLEPGIAAVTNRLGDVLAHTPGYAAVIGAAGLLDHPAPNLTRYVFTDPRARTLFPDWDDIADEQAFDLWLGPSVENSEWLSTELAPVAGPEFTRRLANQLVPRRGPLRLHHPTGPELRLHRETLEFPADAQQLLVLLPADPETATHLTRLTRPAGPHLRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X3</accession>
    <name>A0A1E7N4X3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281559.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene814"/>
    <dbReference type="EnsemblBacteria" id="ARF80943">
        <property type="protein sequence ID" value="ARF80943"/>
        <property type="gene ID" value="B6264_20340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35739">
        <property type="protein sequence ID" value="OEV35739"/>
        <property type="gene ID" value="HS99_0007570"/>
    </dbReference>
    <dbReference type="OMA" id="PAWNLLP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="31336" checksum="9E4C0CF3615DF525" modified="2017-01-18" version="1">MHPDEPVVDAALVRRLISAQFPQWVGLPVTPVGSAGTDNAMFRLGPELAVRLPRVEWAAGDVRREHQWLPRLAPQLPLPVPAPLAVGRPAANYPWEWSVVRWLDGVNPAVGVLAAPEALARDLAGFVNALRSVNPAGAPAGHRSVPLASRDGSTRAAIAQLAGTIDTAAATALWDKALRLPEYAGPPVWMHGDLTPGNLLLNRSGRLAAVIDFALMGVGDPTADLIAAWNLLPASARPAFRAALRADDAMWARGRAWAFSIALVTIPYYRHTDPALTANARHVVREVLADRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N586</accession>
    <name>A0A1E7N586_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0008310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286136.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7231"/>
    <dbReference type="EnsemblBacteria" id="ARF81068">
        <property type="protein sequence ID" value="ARF81068"/>
        <property type="gene ID" value="B6264_21090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35855">
        <property type="protein sequence ID" value="OEV35855"/>
        <property type="gene ID" value="HS99_0008310"/>
    </dbReference>
    <dbReference type="OMA" id="RVIAGWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13814" checksum="0B40706A9B4D7B8A" modified="2017-01-18" version="1">MAVNLNEKPEIDFPIGDAPKELQIRDIVVGDGEEAKPGQTVSVRYVGVTFETGEEFDASWNRSPNEFRFPLGKGRVIKGWDQGVVGMKVGGRRELTIPSHLAYGAQSPTPAIPPHSTLIFVVDLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5E0</accession>
    <name>A0A1E7N5E0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286156.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7242"/>
    <dbReference type="EnsemblBacteria" id="ARF81077">
        <property type="protein sequence ID" value="ARF81077"/>
        <property type="gene ID" value="B6264_21140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35864">
        <property type="protein sequence ID" value="OEV35864"/>
        <property type="gene ID" value="HS99_0008360"/>
    </dbReference>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="PTHR33442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="334" mass="35784" checksum="B01E8EC30F49B3C2" modified="2017-01-18" version="1">MRSRHVFHAVDSHTEGMPTRVITGGFGVIPGATMAERRVHFQQHLDHFRTLLMYEPRGHAAMSGAVLQPPTRPDADFGVLYIEVSGLLPMCGHGTIGVATVLVETGMVPVVEPVTTVRLDTPAGLVVAEVRVEGGAAKAVTIRNVASYAVALDRKIEVPGYGTVGYDLAYGGNFYAILPLAELGLPFERERKQDILDAGLALMAAVNAGPDRPVHPEDPSIHGCHHVQLLAPGSTAEHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLGRDFRNDSFIGTTFTGRLVEETEVAGHPAVVPTVTGRAWVTGTAQYFLDPDDPFPAGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J9</accession>
    <name>A0A1E7N5J9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene791"/>
    <dbReference type="EnsemblBacteria" id="OEV35971">
        <property type="protein sequence ID" value="OEV35971"/>
        <property type="gene ID" value="HS99_0007685"/>
    </dbReference>
    <dbReference type="OMA" id="IGYWIDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="155" mass="16510" checksum="9C5C87633F009120" modified="2017-01-18" version="1">MNRAVRANLEHLRPWMEWAAEAPTRARTAELTRAGTAAWEAGTDFMYLADLDDAPGRVVGAFGLHGRIGPGALEIGYWVAARHVGRGIATAAAGALTEAALALPGIARVEIRCDQANGASAAVPRKLGYRLDRVTEAAARAPGETGRQLVWVKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F7</accession>
    <name>A0A1E7N6F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0030065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550902.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2665"/>
    <dbReference type="EnsemblBacteria" id="OEV36258">
        <property type="protein sequence ID" value="OEV36258"/>
        <property type="gene ID" value="HS99_0030065"/>
    </dbReference>
    <dbReference type="OMA" id="WATGMIE"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="3 11" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="1718"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="2786"/>
            <end position="2861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="11">
        <location>
            <position position="1752"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="11">
        <location>
            <position position="2821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="3099" mass="336459" checksum="9292E1F6239786D3" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6G4</accession>
    <name>A0A1E7N6G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737893.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2621"/>
    <dbReference type="EnsemblBacteria" id="OEV36297">
        <property type="protein sequence ID" value="OEV36297"/>
        <property type="gene ID" value="HS99_0030280"/>
    </dbReference>
    <dbReference type="OMA" id="MPIRPAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="19073" checksum="EB509371E9C007EB" modified="2017-01-18" version="1">MTPRSTPSARRPHPGPGMGAQVAALAAEAERQFRDGLWELAAQDAALARKTAEGLAQALGAETEPEPLPVMDRLERLREALAVLALGIARTHGQLAWFLARASTVLAPVLSWRSLPADRRQSFGTVVPDAEALADAEGAVRRLHAALIRTGTGAVLPPRPGAAPDGLGPDGLEPDGLEPGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I3</accession>
    <name>A0A1E7N6I3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">glyA</name>
        <name evidence="8" type="ORF">HS99_0030225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2633"/>
    <dbReference type="EnsemblBacteria" id="OEV36316">
        <property type="protein sequence ID" value="OEV36316"/>
        <property type="gene ID" value="HS99_0030225"/>
    </dbReference>
    <dbReference type="OMA" id="VVENDQY"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="7">
        <location>
            <begin position="14"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="46088" checksum="F158FB92CD7C0F6B" modified="2017-01-18" version="1">MRDLLVAGAERLAVDDPVLHRVLAREQARQNATLSLVASSSVVDPSVLAAQASTAVNVTAEGYPGRRYHAGCGVIDDIESLAIERAMSVFGARYANVQAHSATTANYAVLSALLDPGDTLLGMNLAEGGHLTHGSPAAYAGQYFDAVGYGLDANGLIDYVQVAELAREHRPKVIICGATAYSRIVDFARFRAVADEVGAYLMADISHVAGLVATGLHPSPVDHAHITTACTHKQLFGPRGGLILVGRDHDAPAPKGNGDLTAFLQRAIFPYYQGAPALNSIAAKARALAIVATPAFAATTERIVAFSRGMAAELVERGYPIVSGGTDNHTVLVDLRARGLSGLVAEEALEECGIVVNKNRVPGDTTPPLVGGGVRLGSNSAAHRGMSGAEAARCAELIDTVLSAVTPLGPRAYRLPDDVRYSVSSQVAELAAKFPLPGYATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q9</accession>
    <name>A0A1E7N6Q9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(4Fe-4S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0029950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554782.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7735"/>
    <dbReference type="EnsemblBacteria" id="ARF82326">
        <property type="protein sequence ID" value="ARF82326"/>
        <property type="gene ID" value="B6264_28715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36382">
        <property type="protein sequence ID" value="OEV36382"/>
        <property type="gene ID" value="HS99_0029950"/>
    </dbReference>
    <dbReference type="OMA" id="HCPVYDK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="471" mass="51149" checksum="12F82547764B33B4" modified="2017-01-18" version="1">MSDTFLGMPAFPQAAARAVRDRQLRANLRHATHTIRDKRARAVAELPDWAELRSAGKAIKDHTLRHLDRYLVQLEEAVTAAGGTVHWAADAEEANRIVAGLVHATGTTEVVKVKSMATQEIGLNEALAAEGVTAYETDLAELIVQLGEDRPSHILVPAIHRNRAEIREIFADRMASWGRPAPEGLTDSPAELAEAARLHLREKFLRAEVAVSGANFMVAETGTLVVVESEGNGRMCLTLPRTLISVVGIEKVVPTWRDLEVFLQLLPRSSTAERMNPYTSLWAGTTRGDGPSEFHLVLLDNGRTAALADQVGRQALRCIRCSACLNVCPVYERAGGHAYGSVYPGPIGAVLTPQLRGTASPVDASLPYASSLCGACYEVCPVAIDIPEVLVHLRERVAEQGGHPVERAAVAAAGYVLDHPAALAAAERLAGRTRALHPRRLPGPGRAWTDSRDLPEVPAEPFRDWWRRNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T0</accession>
    <name>A0A1E7N6T0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0030050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737890.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7756"/>
    <dbReference type="EnsemblBacteria" id="OEV36401">
        <property type="protein sequence ID" value="OEV36401"/>
        <property type="gene ID" value="HS99_0030050"/>
    </dbReference>
    <dbReference type="OMA" id="HLNYLAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="705" mass="76339" checksum="BC6C8500876F5FA6" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N740</accession>
    <name>A0A1E7N740_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid adenylation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283584.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000370.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2637"/>
    <dbReference type="EnsemblBacteria" id="OEV36283">
        <property type="protein sequence ID" value="OEV36283"/>
        <property type="gene ID" value="HS99_0030205"/>
    </dbReference>
    <dbReference type="OMA" id="CTPDIRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="512" mass="54689" checksum="03BDCF3238F29B20" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7B9</accession>
    <name>A0A1E7N7B9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0028720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1467"/>
    <dbReference type="EnsemblBacteria" id="OEV36597">
        <property type="protein sequence ID" value="OEV36597"/>
        <property type="gene ID" value="HS99_0028720"/>
    </dbReference>
    <dbReference type="OMA" id="DERMYGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="383" mass="37792" checksum="E0C2D45A2837A7A0" modified="2017-01-18" version="1">MLPPVPAFDDAAATTLLPPVPPLDDAAATTLLPPVRVSGAMPVAPPQHLGQPPVQQRPVQPQQPSRARHAAPAPQPAAQQAAPAAPPVAGMPGTPLAGLPDAGAGFDPPTMTLKRPGAPAAPPYGSLPAQPTPLAAPPSAPVGTPPGRTGSPIIDPGLQPALITAGVAALLAGGAALGQVALALVVALLQLLTAAGWFRLNGMWPARQGILLAALAGLTADVAVLLADSSGDAAAVVGTLGGFFLLVLVLQTFRPSDPKERFYALTVLGSATVVTALCTALLLADWVPAGVGAVALATLLAAAPLPGPKQLGPVLGLVAAVLLGFLVGAPVALGALAGLGALIGRRVAAYDFPSRFVHMTAGVALPLAVAAPLIWMATDLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7E5</accession>
    <name>A0A1E7N7E5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554824.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7766"/>
    <dbReference type="EnsemblBacteria" id="OEV36616">
        <property type="protein sequence ID" value="OEV36616"/>
        <property type="gene ID" value="HS99_0027950"/>
    </dbReference>
    <dbReference type="OMA" id="WGRITEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="339" mass="34861" checksum="44DEC27E7A570A27" modified="2017-01-18" version="1">MSQSWKPLPDGLSEPARRLAEELRAVKDAHRISLAELGKRTYLSKASWERWLNGKRLITPQALAGMIAALDCDGELLTSLLRQAEAARDAAEGAAPVSEPVPAPVSEPVLAPVSEPVLVPAPVPVAVQAWPTEAPVRSAVLGRAAGWRRPSALLAAAVAVALVLAVSLYLHGLNGGTDAAAAGLPATSAEAGAAPLCQGIGCAGKDPQLMGCENDDHTLLTGNVGQVVLYLHYSPRCRAAWAGITEGAPGDTVTITNRTGWQETALIHWGYDNYSAMVDAGPADTTLRVCGHQPGGDGCLPLVTDPAARAATMAAPSPKAPSPVASVPVTESPTPSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7N3</accession>
    <name>A0A1E7N7N3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385825.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2471"/>
    <dbReference type="EnsemblBacteria" id="ARF81525">
        <property type="protein sequence ID" value="ARF81525"/>
        <property type="gene ID" value="B6264_23755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36695">
        <property type="protein sequence ID" value="OEV36695"/>
        <property type="gene ID" value="HS99_0028470"/>
    </dbReference>
    <dbReference type="OMA" id="MSGLHGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="413" mass="41680" checksum="D569A43C1480820B" modified="2017-01-18" version="1">MTVTTPQTPEPLADPRRSRLSIALVFGVHGAVSGTFVTRIPWIQDRLDLSPGQLGLALVMPAIGSSLAMPLAGRFVHRHGGRAAVRGLISLWCLALALPALAPSLPALCAVLLVYGATAGTADVAMNAQGVEIERCLGRSIMSGLHGMWSAGGLLASGFGILAAHLDLDARLQLAVTALVLLALAQPVCRSLPDFRAPEAAEEPPHFALPPRSSLVIGLVGFCAVFAEGASMDWSGVYLKTVTGASATLAAASYTAFSLTMAVSRLAGDAVIRRLGAVRATRLGGATATLGGVLVVAADHPALAIPGFALIGVGIAVIVPLAFAAAGRIGSNPSQAIAGVATVTYTSGLVAPAVIGALAQATSLTVSFGLVTLLAFALLLSAGALRRAEPDSTDNKVTASSPGNTSGKDLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7W3</accession>
    <name>A0A1E7N7W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829702.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4837"/>
    <dbReference type="EnsemblBacteria" id="ARF82422">
        <property type="protein sequence ID" value="ARF82422"/>
        <property type="gene ID" value="B6264_29280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36797">
        <property type="protein sequence ID" value="OEV36797"/>
        <property type="gene ID" value="HS99_0027730"/>
    </dbReference>
    <dbReference type="OMA" id="ITTMDFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017080">
        <property type="entry name" value="UCP036990_CBS_BON"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036990">
        <property type="entry name" value="UCP036990_CBS_BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="22963" checksum="7B18BE0044A4EF75" modified="2017-01-18" version="1">MPHATVESVMTSPVVRVAPETGFREIVTLMTEYDITGVPVVDPDGRPLGLVSEADLLRTLAAQEDPASLLPAPESAQVGHGGEVTAADLMTAQPVCTTPDTSVVAAARLMSRHGLKRLPVLDEEGRVIGMVSRGDLLRVFLREDRVIRREIVEEVLGRIDGVSPAEIGVEVDQGRVVLSGSVPEAHLVPIVLNLCRAVDGVVSVTDRLQAGGATASIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T5</accession>
    <name>A0A1E7N8T5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease NucS</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nucS</name>
        <name evidence="2" type="ORF">HS99_0026770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282026.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000529.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6455"/>
    <dbReference type="EnsemblBacteria" id="ARF78681">
        <property type="protein sequence ID" value="ARF78681"/>
        <property type="gene ID" value="B6264_06915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36873">
        <property type="protein sequence ID" value="OEV36873"/>
        <property type="gene ID" value="HS99_0026770"/>
    </dbReference>
    <dbReference type="OMA" id="RCSVDYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="219" mass="24082" checksum="72FCACB52479B70B" modified="2017-01-18" version="1">MRLVIARCSVDYAGRLSAHLPSATRLILVKADGSVSIHADDRAYKPLNWMSPPCALKEADGVWTVENKAGEKLIITLEEVLHDSSHELGVDPGLIKDGVEAHLQELLADRMEVLGAGWSLIRREYPTAIGPVDILCRDADGATVAVEIKRRGEIDGVEQLTRYLELLNRDPLLAPVKGIFAAQEIKPQARVLAIDRGIGCVVLDYDELRGIDDDKLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N908</accession>
    <name>A0A1E7N908_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555703.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81599">
        <property type="protein sequence ID" value="ARF81599"/>
        <property type="gene ID" value="B6264_24230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37134">
        <property type="protein sequence ID" value="OEV37134"/>
        <property type="gene ID" value="HS99_0004765"/>
    </dbReference>
    <dbReference type="OMA" id="ICAERTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="14987" checksum="B50A0779EC28BE7D" modified="2017-01-18" version="1">MNPVSRIAAAATGAAALLATPVPALADAPQPPAATTTTCGWSGQQAGLSTKVCAEVTGDRVVVYGQIGLAGPPSPGTPWPPAPQELITGLSAETVGGGSLGAVSGRTVFTVSTVRVDGIVATVPCGSVLHASFAVSSAYRGPVPVTLELPVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N963</accession>
    <name>A0A1E7N963_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555244.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000622.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1339"/>
    <dbReference type="EnsemblBacteria" id="OEV37235">
        <property type="protein sequence ID" value="OEV37235"/>
        <property type="gene ID" value="HS99_0005380"/>
    </dbReference>
    <dbReference type="OMA" id="FHNDSIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="172" mass="18264" checksum="C5412E95C46EACE0" modified="2017-01-18" version="1">MAQQDAAHGAPSLDQARRQIARYGLTADPQAVLVAARLMAAGARLGQAGEAHFARFGLSTGRYRLLADLEDHGGEKSPSQLAASLGVSRATVTGLVDGLEREGLVARRPAVEDGRGNVVILTARGAQRLRELAPEHYRRMQAMVGGLSPEERAVFLDLLARLVDGMDALTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G7</accession>
    <name>A0A1E7N9G7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="8" type="ORF">HS99_0006010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556492.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37337">
        <property type="protein sequence ID" value="OEV37337"/>
        <property type="gene ID" value="HS99_0006010"/>
    </dbReference>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="20597" checksum="B11EC119A2636B0C" modified="2017-01-18" version="1">MERIITTHNASQSQPETVTRAVGKRTLALTALVTAAVLTYALDLGSKLVAVSRLEGQEPVAITGHVLTLQVFRNSGAAFSSGQAFTVVFTAIAVAVVVVVARAARRLQSLPWAVALGLLLGGALGNLTDRTFREPAVFRGHVVDFISVEHFAVFNLADSGIVCGGALMVLMTIRGTSLDGSAPQDRQSRSILFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P1</accession>
    <name>A0A1E7N9P1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558127.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000649.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83163">
        <property type="protein sequence ID" value="ARF83163"/>
        <property type="gene ID" value="B6264_29880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37406">
        <property type="protein sequence ID" value="OEV37406"/>
        <property type="gene ID" value="HS99_0006420"/>
    </dbReference>
    <dbReference type="OMA" id="DHMILLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="71" mass="7475" checksum="8D4D531A851E39AC" modified="2017-01-18" version="1">MNAEVGNVTALILLGILALTIGGCACVVWAERGGPRWARAVATVTLTAGELVRRFGKNRSRSGNRATDDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA62</accession>
    <name>A0A1E7NA62_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286450.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1109"/>
    <dbReference type="EnsemblBacteria" id="ARF78992">
        <property type="protein sequence ID" value="ARF78992"/>
        <property type="gene ID" value="B6264_08740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37577">
        <property type="protein sequence ID" value="OEV37577"/>
        <property type="gene ID" value="HS99_0026615"/>
    </dbReference>
    <dbReference type="OMA" id="WAVWHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="147" mass="15193" checksum="765CCDA5ADAA31EA" modified="2017-01-18" version="1">MQPHGLIVVGVDGSAPARAAVRWAARLAGLTGGPLEAVAVWDFPCLLGEHGLVPPALDGFESERRAAEILAETAGACTVPVRRRLRTGPPGPALVAAATGAALLVLGNRGHGTPPDAPLGTVAQYCLHHAPCPVVIVRRDQSREDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA72</accession>
    <name>A0A1E7NA72_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286534.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1156"/>
    <dbReference type="EnsemblBacteria" id="ARF82712">
        <property type="protein sequence ID" value="ARF82712"/>
        <property type="gene ID" value="B6264_08975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37595">
        <property type="protein sequence ID" value="OEV37595"/>
        <property type="gene ID" value="HS99_0026380"/>
    </dbReference>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="336" mass="35714" checksum="48E571D78914AA33" modified="2017-01-18" version="1">MTVVGPFGLSVQDRDLTRDVQAGLEAVEAALSEAVKSDVPFITVTASHLMEAGGKRFRPLLLLLAAQFGDPGAPGVVPAAVVVELTHLATLYHDDVMDEAPVRRGTESANSRWDNSVAILTGDFLFSRASQVLADLGPEAVRMQAEAFERLVTGQILETRGPGPDGDPLLHYLDVLAGKTGSLIAVSCRIGALMAGAEPWLVETLGDFGERIGIAFQLADDVLDIASDGDESGKTPGTDLREGVATLPTLLLQQMPADPGDPDDTRLRELLAKDLSDDDLHAEALRLLRAHPALERARRETLRHAEEARALLAPLPDCAAKAALDGLCDAVAIRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAE8</accession>
    <name>A0A1E7NAE8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">HS99_0025575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280772.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1679"/>
    <dbReference type="EnsemblBacteria" id="ARF79932">
        <property type="protein sequence ID" value="ARF79932"/>
        <property type="gene ID" value="B6264_14365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37675">
        <property type="protein sequence ID" value="OEV37675"/>
        <property type="gene ID" value="HS99_0025575"/>
    </dbReference>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="10511" checksum="72950EAE6BA10D82" modified="2017-01-18" version="1">MPRSLKKGPFIDGHLIKKVDAQNEAGTQNVIKTWSRRSVISPSMLGHTIAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFRGHVKEDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF1</accession>
    <name>A0A1E7NAF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mismatch-specific DNA-glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284162.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000498.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8013"/>
    <dbReference type="EnsemblBacteria" id="ARF79867">
        <property type="protein sequence ID" value="ARF79867"/>
        <property type="gene ID" value="B6264_13990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37614">
        <property type="protein sequence ID" value="OEV37614"/>
        <property type="gene ID" value="HS99_0025205"/>
    </dbReference>
    <dbReference type="OMA" id="FWPVLHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="PTHR12159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19889" checksum="EA07678E68F85651" modified="2017-01-18" version="1">MRPTPEQLQAAQGTTIPDVTGPGLRVLFCGINPGLWSGATGHHFARPGNRFWPALHRSGFTVRQYRPDEQGELPALGLGITNVAPRTTAKADELTAEELREGGAALRERVLRLRPRVLAVLGIGAYRTAFGKRQAAIGRQPEGIGDTEVWVLPNPSGLNAHYPLDALAAEFRKLRQSVEGADTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF5</accession>
    <name>A0A1E7NAF5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">HS99_0025600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280777.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1674"/>
    <dbReference type="EnsemblBacteria" id="ARF79937">
        <property type="protein sequence ID" value="ARF79937"/>
        <property type="gene ID" value="B6264_14390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37680">
        <property type="protein sequence ID" value="OEV37680"/>
        <property type="gene ID" value="HS99_0025600"/>
    </dbReference>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="10262" checksum="63C0C5D2EBF068FD" modified="2017-01-18" version="1">MTENTNETRGFRKTREGLVVSDKMDKTVVVAVEDRVKHALYGKVIRRTNKLKAHDEQNACGVGDRVLLAETRPLSATKRWRVVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAF8</accession>
    <name>A0A1E7NAF8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name evidence="4" type="ORF">HS99_0025630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280782.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1668"/>
    <dbReference type="EnsemblBacteria" id="ARF79942">
        <property type="protein sequence ID" value="ARF79942"/>
        <property type="gene ID" value="B6264_14420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37685">
        <property type="protein sequence ID" value="OEV37685"/>
        <property type="gene ID" value="HS99_0025630"/>
    </dbReference>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19142" checksum="108BED402B9B667F" modified="2017-01-18" version="1">MSRIGRLPIQVPAGVDVTIDGQTVAVKGPKGSLTHVVAEPIEIGKGEDGTVLVTRPNDERRSKALHGLTRTLVANMITGVTAGYRKSLEISGVGYRVTAKGSDMEFALGYSHPILITAPEGISFVVESPTKFHVDGIDKQKVGEIAANIRKLRKPDPYKAKGVKYAGEVIRRKVGKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG2</accession>
    <name>A0A1E7NAG2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">HS99_0025580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280773.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1678"/>
    <dbReference type="EnsemblBacteria" id="ARF79933">
        <property type="protein sequence ID" value="ARF79933"/>
        <property type="gene ID" value="B6264_14370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37676">
        <property type="protein sequence ID" value="OEV37676"/>
        <property type="gene ID" value="HS99_0025580"/>
    </dbReference>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="115" mass="12865" checksum="6CB2811C31756B92" modified="2017-01-18" version="1">MEARAQARYIRVTPMKARRVVDLIRGMNATEAQAVLRFAPQAATVPVGKVLDSAIANAAHNYNHSNVDDLYISEAYVDEGPTLKRFRPRAQGRAYRIRKRTSHITVVVSSKEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAI7</accession>
    <name>A0A1E7NAI7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="8" type="ORF">HS99_0025705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385839.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1653"/>
    <dbReference type="EnsemblBacteria" id="ARF79956">
        <property type="protein sequence ID" value="ARF79956"/>
        <property type="gene ID" value="B6264_14495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37699">
        <property type="protein sequence ID" value="OEV37699"/>
        <property type="gene ID" value="HS99_0025705"/>
    </dbReference>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="33520" checksum="653D63147425EE92" modified="2017-01-18" version="1">MVNDCAEQPPVKDGPADGYVRVRLDLAYQGAEFSGWARQKGGRRTVQEEIETALQIVTRSPELFPLTVAGRTDAGVHARGQVAHVDLPAELWEAHREKLLRRLAGRLPGDVRIYRVGEAPAGFDARFSAIWRRYAYRVADHPGGVDPLLRGHVLWHDRPLDVEKMNAAAKLLLGEHDFAAYCKKREGATTIRTLLELHWDRVPVDTYASQEGSLAVATVRADAFCHNMVRALVGAMLLVGDGHRPVEFPGEVLAGGVRNSAVNVIRPYGLTLEEVGYPPDDQFAERNRQARRMRTLPGQPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAV2</accession>
    <name>A0A1E7NAV2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78040">
        <property type="protein sequence ID" value="ARF78040"/>
        <property type="gene ID" value="B6264_03085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37826">
        <property type="protein sequence ID" value="OEV37826"/>
        <property type="gene ID" value="HS99_0024900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8086" checksum="15EC6FDE35FD466C" modified="2017-01-18" version="1">MAALAPLAVAATLVLLTAWSAAGRAGRGAPVAALDAKVMVPAAPGAPTAALVVLRNPGDILERLTGARWGAVSVPPGGLGAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB70</accession>
    <name>A0A1E7NB70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-oxoisovalerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2069"/>
    <dbReference type="EnsemblBacteria" id="ARF79494">
        <property type="protein sequence ID" value="ARF79494"/>
        <property type="gene ID" value="B6264_11725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37940">
        <property type="protein sequence ID" value="OEV37940"/>
        <property type="gene ID" value="HS99_0024050"/>
    </dbReference>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="324" mass="35397" checksum="0C2A68A1B8F27E10" modified="2017-01-18" version="1">MAGQLSIAKALNDALRKSLEKDPKTVLMGEDIGKLGGVFRITDGLQKDFGEDRVIDSPLAESGIMGTAIGLALRGYRPVVEIQFDGFVYPAFDQIVSQLAKMHARALGHVKMPVTVRIPYAGGIGAVEHHSESHEAYFAHTAGLRVVTPSNAHDAHWMLRQAIESDDPVIFLEPKRRYWDKGEVGATADLALHDARIVRPGTDATLIAYGPMVKVCLEAAAAAEEDGRRLEVVDLRSLSPVDFTTLEESVKRTGRAVVVHEAPVFLGMGAELAARLTERCFYHLEAPVLRVGGYYAPYPPSRVEEAFLPDLDRVLDAVDRALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB73</accession>
    <name>A0A1E7NB73_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0024025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737826.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2074"/>
    <dbReference type="EnsemblBacteria" id="ARF79490">
        <property type="protein sequence ID" value="ARF79490"/>
        <property type="gene ID" value="B6264_11700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37937">
        <property type="protein sequence ID" value="OEV37937"/>
        <property type="gene ID" value="HS99_0024025"/>
    </dbReference>
    <dbReference type="OMA" id="MAPRIEN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="51207" checksum="541287BE8E7E9287" modified="2017-01-18" version="1">MSEHGNAVEGFSLGNGRYVLQRLLGEGGMASVHLAYDSVLDRQVALKSMHSELGRDDSFKERFRREAQAVARLEHPNIVTVYDSGEDVAPDGSSTPYIVMQLIDGKGLRETINEAVAQHGAVPAEEALKVTVGVLNALEASHDMGLVHRDIKPGNVMFDRKGNVKVMDFGIARALESGVTSMTQTGMVVGTPQYLSPEQALGKPVDARSDLYSVGVMLFEMLTGQLVFDGDSAFSIAYKHVQEEPPAPSSLNRSITPAVDAYVAQALRKDPAHRFQSAAAMRDEAERLIAELKGGGSGHALQASSPLVIKEGPRSVHAGPQAPQTPHPQYLQQGGQPQYQTPPPAYQTPHPQAPRTPHPFPQQQQPQYRTPPPAYQTPRPQAPHTPHPFPQQGQRPPMHTPGPQPMPPYQQPKPNGGGCSTAFVVIAIIVGVLVLAGIIIAIVVNKAEKNTNGKFHSERPAAVVVVGPQADRNGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBM3</accession>
    <name>A0A1E7NBM3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoprenylcysteine carboxyl methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288457.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3009"/>
    <dbReference type="EnsemblBacteria" id="ARF79704">
        <property type="protein sequence ID" value="ARF79704"/>
        <property type="gene ID" value="B6264_13025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38085">
        <property type="protein sequence ID" value="OEV38085"/>
        <property type="gene ID" value="HS99_0023075"/>
    </dbReference>
    <dbReference type="OMA" id="YGWRIAA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20968" checksum="262D76735D5551FF" modified="2017-01-18" version="1">MSLPSLLSLLGLLCWIAYELLLRRREDGEAGTWHTDDRDRGSTRLLLSCYAASVPAVVLFDRASIGEPPTWARWFGVALVLAGLALRAWGMRTLGRYYTRTLRTVATQHVVRSGPYRLIRHPGYAGSLLVWIGYALGAGGWAAALVVAALLLGAYGWRIAAEERLLLASFGPAYARYRKESKRLVPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT3</accession>
    <name>A0A1E7NBT3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063736128.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7132"/>
    <dbReference type="EnsemblBacteria" id="ARF79643">
        <property type="protein sequence ID" value="ARF79643"/>
        <property type="gene ID" value="B6264_12660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38147">
        <property type="protein sequence ID" value="OEV38147"/>
        <property type="gene ID" value="HS99_0023430"/>
    </dbReference>
    <dbReference type="OMA" id="DAMMLDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="42366" checksum="01863FB7D34185AB" modified="2017-01-18" version="1">MTSTNSGMASANSGMASTGSRLAVDGLIDDPGTRIIVCCGSGGVGKTTTAAAIGLRAAERGRKVVVLTIDPARRLAQSMGLTELDNTPRVVKGVTGNGELQAMMLDMKRTFDEVVLAHAEPERARAIMENPFYQSLSAGFAGTQEYMAMEKLGQLRAAEEWDLIVVDTPPSRSALDFLDAPNRLGSFLDGRVIRILTAPAKVGGRSAMRFLNAGMGLLTGTLGKIFGAQLLTDVQTFVSATDSMFGGFRERADRTYQLLKAPGTAFLVVAAPERDALREAAYFVDRLAADRMPLAGLVLNRVHSTGAPQLTAERALAAAEALDDNGSEHSSPEAELLAAGLLRLHAERMQIMGRERRTRDRFVSVYPDVPIVEVAALPGDVHDLDGLRAIGERLSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC50</accession>
    <name>A0A1E7NC50_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030061050.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000685.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3049"/>
    <dbReference type="EnsemblBacteria" id="ARF79737">
        <property type="protein sequence ID" value="ARF79737"/>
        <property type="gene ID" value="B6264_13225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38053">
        <property type="protein sequence ID" value="OEV38053"/>
        <property type="gene ID" value="HS99_0022875"/>
    </dbReference>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="25400" checksum="89358745E7D8AC82" modified="2017-01-18" version="1">MTRVLVVEDEESFSDALSYMLRKEGFEVAVAATGPDALEQFERNGADLVLLDLMLPGLPGTEVCRQLRVRSNVPVIMVTAKDSEIDKVVGLEIGADDYVTKPYSTRELVARIRAVLRRRGEDGGAGENGGGPGALEAGPVRMDVDRHVVTVDGAKVDLPLKEFDLLEMLLRNAGRVLTRMQLIDRVWGADYVGDTKTLDVHVKRLRAKIEPDPGAPRYLVTVRGLGYKFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC56</accession>
    <name>A0A1E7NC56_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0022250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291137.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000326.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1728"/>
    <dbReference type="EnsemblBacteria" id="ARF80217">
        <property type="protein sequence ID" value="ARF80217"/>
        <property type="gene ID" value="B6264_16020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38265">
        <property type="protein sequence ID" value="OEV38265"/>
        <property type="gene ID" value="HS99_0022250"/>
    </dbReference>
    <dbReference type="OMA" id="DTTGPLH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="279" mass="29340" checksum="1DE9A78E0EB4244D" modified="2017-01-18" version="1">MPTYETDGPISVALDFEIGSVWIRASKRTDAVVEVRPTSATRDADIKAAELTQIDFSGGRLTLKGPKQRTVFSSRKGSVEITVELPAGSEVHAESPMSDFVAEGPLGDCRIKTSMGRIQLDRAENVRIKTDMGDIRLGNAAGDAEVTGSGRIEVGTVGGRLTVKNSNGDTEIDEARGELTANSSNGRIHVGTAEAGVQAKTANGHIRLGRVVRGRVDLQAGVGDVEVGIAEGTAAWLDVHSKFGAIRNDLGPAQGPGDARETVEVRGTTQVGSITIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCE0</accession>
    <name>A0A1E7NCE0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0022550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4160"/>
    <dbReference type="EnsemblBacteria" id="OEV38360">
        <property type="protein sequence ID" value="OEV38360"/>
        <property type="gene ID" value="HS99_0022550"/>
    </dbReference>
    <dbReference type="OMA" id="MEPAYGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="8">
        <location>
            <begin position="56"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="479"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="813" mass="87355" checksum="A60C841588B2B59F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCG3</accession>
    <name>A0A1E7NCG3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386601.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene245"/>
    <dbReference type="EnsemblBacteria" id="ARF82228">
        <property type="protein sequence ID" value="ARF82228"/>
        <property type="gene ID" value="B6264_28110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38381">
        <property type="protein sequence ID" value="OEV38381"/>
        <property type="gene ID" value="HS99_0020945"/>
    </dbReference>
    <dbReference type="OMA" id="RCETRLY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="17835" checksum="02A4EABA5D929FE8" modified="2017-01-18" version="1">MEDTLDGGRPAAGPTGLFSELFADLVRCETRLYNALNDRLRERHGIVTSQYEFLDYLRRHPGCRVADIAAEFAIGVGATSKGIDRLEKQGWAARRPNPADRRSSLLALTTAGTRLVEEAQRTFTDTLAELLTGTLDAASLSAAARTFATLRAALERDRIGTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR9</accession>
    <name>A0A1E7NCR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene316"/>
    <dbReference type="EnsemblBacteria" id="ARF82164">
        <property type="protein sequence ID" value="ARF82164"/>
        <property type="gene ID" value="B6264_27755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38444">
        <property type="protein sequence ID" value="OEV38444"/>
        <property type="gene ID" value="HS99_0021300"/>
    </dbReference>
    <dbReference type="OMA" id="DMELRNI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="19567" checksum="80629ADDEF5C10B7" modified="2017-01-18" version="1">MVRSAVLLLLTTSTAACAAGPDAETYRIAPDNANADIGDLELRDVRLVAGPGGSGSATLAAYILNPGAEPDTLTAVSLAGAGSAPAGGGGAGITLPPGEPVLVGAPGQPEVQVSGNVSPGTYELVTFTFARAGRGTVNASVVSAASPSPGGGVASQTPGSPSPTAGTTSGASPSLAPGGGAPTAERSALPTETASGVASPAARSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND04</accession>
    <name>A0A1E7ND04_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348403.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000379.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene672"/>
    <dbReference type="EnsemblBacteria" id="ARF77594">
        <property type="protein sequence ID" value="ARF77594"/>
        <property type="gene ID" value="B6264_00440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38569">
        <property type="protein sequence ID" value="OEV38569"/>
        <property type="gene ID" value="HS99_0020025"/>
    </dbReference>
    <dbReference type="OMA" id="AWARGPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="25338" checksum="AED5D07B1E319E5B" modified="2017-01-18" version="1">MTTALPERDGHEAVVTLDRREGPFGEVVLRQRGRHYEIIANGCFLMDTADGRSERLLVQAALDELDRTGAAVTAPSVLIGGLGVGFSLAYAVAEPRWGRIAIVERENAIIDWHRSGPLGGFSGGALDDERVEVIHTDLLGYLAASDGERYDALCLDIDNGPDWTVTDSNSGLYGADGLAVLWHRLRPGGVLAVWSAQPSPDFEEALRAAGFADVVSREVPVSRGVPDVVHLARRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND37</accession>
    <name>A0A1E7ND37_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene634"/>
    <dbReference type="EnsemblBacteria" id="OEV38595">
        <property type="protein sequence ID" value="OEV38595"/>
        <property type="gene ID" value="HS99_0020225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="25432" checksum="9F2477A455D7E0EA" modified="2017-01-18" version="1">MLGLHDPRTTTVSGSIRLDGQELVGAGEPLLRGVRGGRAALVLQDALTSLSPFHGVGAQLAETYRLHHPRAGRAEARRRAAEMLDRVGIPSARLRDHPHRFSGGTRQRVVIAMALMNEPRLLIADEPTTALDARVQRQVLDLPGELQCEHGTAVLLVSHDLGVVAGTTDRTLVLRDGSEVESAPTGELLAAPRAPYTRALVGAALRTDSVPGSGRGALIAAPGRRCSPFVRLRGRGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC6</accession>
    <name>A0A1E7NDC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000379.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene669"/>
    <dbReference type="EnsemblBacteria" id="ARF82528">
        <property type="protein sequence ID" value="ARF82528"/>
        <property type="gene ID" value="B6264_00455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38702">
        <property type="protein sequence ID" value="OEV38702"/>
        <property type="gene ID" value="HS99_0020040"/>
    </dbReference>
    <dbReference type="OMA" id="ADIGFMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="301" mass="32739" checksum="3E13A6144F876435" modified="2017-01-18" version="1">MFDSRHIRTFHEVVRAGSYSAAARELGYTQPAITQQMKALERTVGVPLFTRAGRGLRLTEAGEALSRHAELILGSLSAAQQQLAALARLRAGRVRVCAFPSANATLIPEAMARLLAEHPGVRVELLEAEPPDSVQRLLRGECDIALAFRYPGQATEVPDGLDEIPLMEDLLTVLLPVGHSLGRRHAVRLADLDGERWIAGCPRCRANLLHVCAEEGFAPDIVFSTDDNLAVQSLVAAGVGIALMPALVLSFMCHRKVTGRAVEPHLRRQVSAYVLREHRRIPATALVLDHLRQAAASRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDD6</accession>
    <name>A0A1E7NDD6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-hydroxy-3-oxopropionate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0020675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282968.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000437.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1788"/>
    <dbReference type="EnsemblBacteria" id="ARF77701">
        <property type="protein sequence ID" value="ARF77701"/>
        <property type="gene ID" value="B6264_01090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38668">
        <property type="protein sequence ID" value="OEV38668"/>
        <property type="gene ID" value="HS99_0020675"/>
    </dbReference>
    <dbReference type="OMA" id="IFVDHTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008679">
        <property type="term" value="F:2-hydroxy-3-oxopropionate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006398">
        <property type="entry name" value="Tartro_sem_red"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01505">
        <property type="entry name" value="tartro_sem_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="29812" checksum="8FC58F4FEC3B267B" modified="2017-01-18" version="1">MSASRKIAFVGLGIMGKPMAVNLVKAGHHVTGFDLSQASIDTVVAAGGHGAASIADAVKDAEVVITMVPADPHVEAVILGEGGVLENVGAGTLVIDMSSITPQTSIKVGKAAREKGVRTLDAPVSGGEAGAIEAVLSIMVGGEAADFAEAKPLFDALGTTVVHVGPDGAGQTVKAANQLIVAVNIQVLAEAVVFLENAGVDLAAALDVLGGGLAGSTVLNRKKANMLNREFAPGFRIDLHHKDMGIVTDAARAVGAALPVGAVVAQLVASARANGDGPLDHSALLRGVERLSGREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDM7</accession>
    <name>A0A1E7NDM7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="14" type="ORF">HS99_0019210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290280.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000241.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7394"/>
    <dbReference type="EnsemblBacteria" id="ARF81208">
        <property type="protein sequence ID" value="ARF81208"/>
        <property type="gene ID" value="B6264_21945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38800">
        <property type="protein sequence ID" value="OEV38800"/>
        <property type="gene ID" value="HS99_0019210"/>
    </dbReference>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV38800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="402" mass="43550" checksum="D5592A58EA1C28B1" modified="2017-01-18" version="1">MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGQVHVAGEVTTKAYAPIAQLVRDKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDTAYEARVEGDEDDLDKQGAGDQGLMFGYASDETPELMPLPITLAHRLSRRLTEVRKNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSTQHASDIDLESLLTPDIREFVVEPELKALAEQGIKLNTDGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNIVAAGLASRAEVQVAYAIGKAEPVGLFVETFGTETVPVLTIQKAVSEVFDLRPAAIIRDLDLLRPIYSQTAAYGHFGRELPDFTWERTDRVEQLKAAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDN1</accession>
    <name>A0A1E7NDN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385646.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF77620">
        <property type="protein sequence ID" value="ARF77620"/>
        <property type="gene ID" value="B6264_00625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38593">
        <property type="protein sequence ID" value="OEV38593"/>
        <property type="gene ID" value="HS99_0020210"/>
    </dbReference>
    <dbReference type="OMA" id="PVPWPCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="19538" checksum="1021AC781FA90F1C" modified="2017-01-18" version="1">MTAAERDRTETQANALSVELTAMMAEDNTAARLAHSPDLAEQAVWRRLTARHGDRLSEIMAEHGWPTERTVGADAARAAWLVAQHADRQLEVQRRAVQLMAEAVADGAASARDLGFLRDRLAVNEGRPQRYGTQIGAVADGRPVPWPCEDPERLDERRAQVGIEPFDQYTARFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDQ5</accession>
    <name>A0A1E7NDQ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">rRNA cytosine-C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0019235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386157.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000241.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7399"/>
    <dbReference type="EnsemblBacteria" id="OEV38804">
        <property type="protein sequence ID" value="OEV38804"/>
        <property type="gene ID" value="HS99_0019235"/>
    </dbReference>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="8">
        <location>
            <begin position="206"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="310"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="495" mass="52713" checksum="F981866EB5D73283" modified="2017-01-18" version="1">MSTPSSRGNSGTPGSSGRPGNSGAGRAPRPHRRPKKDPARIVAFRALRAVDERDAYANLILPSLLREAEQKGMDRRDAALATELVYGTLRLQGTYDAIIAACIDRPLSKVDPPVLDVLSLGAHQLLTTRIPSHAAVSATVELARVVLGDGKAKFVNAVLRRISAHDLDGWIEQVAPPYDKDAEDHLAVVHSHPRWVVSALWDSLGRWQPDASGRTAVEELLRADNERPEVTLVARPGRATVGELADALPEATPGRWSPFALRLAEGGDPGTLTAVRENRAGVQDEGSQLVALALAAAPLEGPDRLWLDGCAGPGGKAALLGALAAERGAALVASEKQPHRARLVARALEGNPGPYTVIAADGTRPAWRSGGFDRVLVDVPCSGLGALRRRPEARWRRRPADVAAFGPLQRDLLRSAIEATRVGGVVGYATCSPHLAETRAVVDDVLRGEGGRVEWVDARPLLPGVPALGDGPDVQLWPHLHGTDAMYLALLRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE46</accession>
    <name>A0A1E7NE46_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290491.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6549"/>
    <dbReference type="EnsemblBacteria" id="ARF81317">
        <property type="protein sequence ID" value="ARF81317"/>
        <property type="gene ID" value="B6264_22580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38908">
        <property type="protein sequence ID" value="OEV38908"/>
        <property type="gene ID" value="HS99_0019845"/>
    </dbReference>
    <dbReference type="OMA" id="FWCEVLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="13964" checksum="2A4BC8F35DD65C2A" modified="2017-01-18" version="1">MACRISELVLGCREPEVLARFWCEVLDFVVLGREDDGSIEIGPREGFGGAQPTLFLSRREAPEPGKPRLHIDVNATDRDQEAELERLLALGARPADIGQTGEESWHVLADPEGNEFCLLKARLNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE49</accession>
    <name>A0A1E7NE49_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557349.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83215">
        <property type="protein sequence ID" value="ARF83215"/>
        <property type="gene ID" value="B6264_30190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38986">
        <property type="protein sequence ID" value="OEV38986"/>
        <property type="gene ID" value="HS99_0017920"/>
    </dbReference>
    <dbReference type="OMA" id="MTEVRHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24900" checksum="125B1962B55AAF2A" modified="2017-01-18" version="1">MRFPSRGQLAVLSEAEFEALASLHFAMTEVRHEWGTSRAALDRLFALSDHAEHLDDGARFTFRSRALDEVRRASYQYTDAVEKVMWPCVSAYTVLGIAVLERVVDGKVPLTDQVVAELAEEPTLGQLHAALSVPVPALLTARDAQSVESAQERREQLLARVEVIYECLDDPMLPSPLTREQAAVSRLTEAQPEGTDALWEGLLEPLVLLAGQTPSDVAFHLRQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED2</accession>
    <name>A0A1E7NED2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835644.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1003"/>
    <dbReference type="EnsemblBacteria" id="ARF83290">
        <property type="protein sequence ID" value="ARF83290"/>
        <property type="gene ID" value="B6264_30625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39057">
        <property type="protein sequence ID" value="OEV39057"/>
        <property type="gene ID" value="HS99_0018340"/>
    </dbReference>
    <dbReference type="OMA" id="WPRCEAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="23148" checksum="32C53CCFD6FFB634" modified="2017-01-18" version="1">MEATLAALAPRLQLSRPGPLVPVLPALEGLLPERGLRPGAVVSVTGGATALALALAAAATASGMYCAALGFDGLGALAAAELGVDVGRLVVVDAPRERRAEVALALADGFGLLLLQGAPVAGPVAERLVTVARRSGCAVVVAGEWPGARVRLRVVSRVWEGLGQGRGRLRARRLAVVAGGRGAAARERRAELWLPDAQGAVRLVERPAAPAAAPQRRAHAGRGPLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEI2</accession>
    <name>A0A1E7NEI2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557173.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83338">
        <property type="protein sequence ID" value="ARF83338"/>
        <property type="gene ID" value="B6264_30945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39109">
        <property type="protein sequence ID" value="OEV39109"/>
        <property type="gene ID" value="HS99_0018670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="81" mass="8376" checksum="93AFCA7ABF6690BC" modified="2017-01-18" version="1">MTPVQSVLQFLADVVASVAWPQADQLAHAVRNVGFVLSTVSAAVNALAAIRKRRTSKDPVALPVLGCCGACPAHRPQAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT5</accession>
    <name>A0A1E7NFT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385471.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6731"/>
    <dbReference type="EnsemblBacteria" id="OEV39561">
        <property type="protein sequence ID" value="OEV39561"/>
        <property type="gene ID" value="HS99_0002450"/>
    </dbReference>
    <dbReference type="OMA" id="GPEYIYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15230" checksum="73C5391DEC4652CF" modified="2017-01-18" version="1">MTSSVTDAGRTAQAPENRPFVTGWTVFAAIMLIAGGIMAIFEGIAGIAKDSLIVVTRHYVYSMNTTGWGWIHLILGVVLVLAGVALFSGAVWARAVGVVVAGLGMIANFLWLPYYPFWAVVLIALDVFVIWALCVGTVRKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFT9</accession>
    <name>A0A1E7NFT9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555603.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6735"/>
    <dbReference type="EnsemblBacteria" id="OEV39557">
        <property type="protein sequence ID" value="OEV39557"/>
        <property type="gene ID" value="HS99_0002425"/>
    </dbReference>
    <dbReference type="OMA" id="GRWAQQD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="88" mass="9143" checksum="0C617A683B1421CE" modified="2017-01-18" version="1">MPGLIRGVARTAVVAGTATAVSNRVSRRQAGRWAQQDQAAAYRDPPPAAAPGSTDDTIAQLQKLGALKEQGVLTEAEFATQKAKILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG52</accession>
    <name>A0A1E7NG52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2800"/>
    <dbReference type="EnsemblBacteria" id="OEV39657">
        <property type="protein sequence ID" value="OEV39657"/>
        <property type="gene ID" value="HS99_0003035"/>
    </dbReference>
    <dbReference type="OMA" id="KTIWCAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="803" mass="85030" checksum="3FCE9261520B23E4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG55</accession>
    <name>A0A1E7NG55_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279391.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2840"/>
    <dbReference type="EnsemblBacteria" id="OEV39690">
        <property type="protein sequence ID" value="OEV39690"/>
        <property type="gene ID" value="HS99_0003230"/>
    </dbReference>
    <dbReference type="OMA" id="YMIHRAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022468">
        <property type="entry name" value="PhnX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03351">
        <property type="entry name" value="PhnX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="229" mass="23951" checksum="F4606693B480207B" modified="2017-01-18" version="1">MIELAALDMAGTTINESGAVYRALRTAVERNGVAVAEADLQAWMGTDKREAIAALVRLGGGTPTPELVEESYAAFAEYLREAYRTTPPQAVPGVEEALAELRRRGIKVALTTGFSGDVAYPLLESLGWSTGEGGNLDAVVTSDEVPRGRPAPYMIHRAMQKTGVIDTRRVLTAGDTVVDVEAGRNAGAGVVVGVLTGELGRADFDGHPQTHVLASAAEIPGLAEARPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG58</accession>
    <name>A0A1E7NG58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrophobic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279177.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2739"/>
    <dbReference type="EnsemblBacteria" id="OEV39605">
        <property type="protein sequence ID" value="OEV39605"/>
        <property type="gene ID" value="HS99_0002725"/>
    </dbReference>
    <dbReference type="OMA" id="FWWIAVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="56" mass="6403" checksum="8D5F4D6A5FF66959" modified="2017-01-18" version="1">MGALLLVLLLAVVLFGLGFAVKVLWWVALFVLAVWLLGFVVRTVDDAGGRRRWYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG87</accession>
    <name>A0A1E7NG87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279297.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2801"/>
    <dbReference type="EnsemblBacteria" id="OEV39658">
        <property type="protein sequence ID" value="OEV39658"/>
        <property type="gene ID" value="HS99_0003040"/>
    </dbReference>
    <dbReference type="OMA" id="DWKIMAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="31742" checksum="A0386BE3B5CF6629" modified="2017-01-18" version="1">MRAVTYDSYAQDNSRLKYGEVPDPKVGPGQVLIQVRAASVNPVDWKVMAGGLDGMMDTVFPVIPGWDVAGVVTRTGPDTPEFAPGDEVMAYARKDVVQAGTFAEYVAVAAPAVARKPSGLDWAQAAGLPLAGLTALRSLDRLDVGPSDVLLVHGAAGGVGSLAVQLGRDRGARVIGTASERNHAFVRGLGAEPVTYGDGLTERVRALAPGGVSTVADFVGGQLETTLAVLAEGGRHVSVADPGVSQHGGHWIWVRPDGAALAELAAVVDRGALTVEVARTFPLERTAEAFDASRTGHTRGKLVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA1</accession>
    <name>A0A1E7NGA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367064.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2857"/>
    <dbReference type="EnsemblBacteria" id="OEV39704">
        <property type="protein sequence ID" value="OEV39704"/>
        <property type="gene ID" value="HS99_0003320"/>
    </dbReference>
    <dbReference type="OMA" id="KLPTHRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="14619" checksum="3B5D7E5E32E003BD" modified="2017-01-18" version="1">MNDQESTSSAPSRGTALLLRPVESAASAVRRVPGAGAVGGMVDGVLDTVGLVSPRARRIAAYTGAGLLGAVGAVEWPVAAAGAAAVWLTQARPKSSTGSAATPAREGAPAAKSRTTEAPKASRSGGTAPSRRRTTIAASAGSSRRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGF3</accession>
    <name>A0A1E7NGF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367068.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000177.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2887"/>
    <dbReference type="EnsemblBacteria" id="OEV39728">
        <property type="protein sequence ID" value="OEV39728"/>
        <property type="gene ID" value="HS99_0003460"/>
    </dbReference>
    <dbReference type="OMA" id="IHVESPV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="24206" checksum="BAF3030A245F8EEB" modified="2017-01-18" version="1">MSAQKPGPSGRRARVAALRAAEVRHARARRWLRVGLIGLLVLVVIGGIAVVIATNQDSTAPSGVPAHPRTTAAGRTTPPPWDAPADVAAAVKAAGLPMLGAEGTALHIHAHLDVYADGHAVTVPALVGIDESAQKISPLHTHDTTGVIHVESPVSADFTLGQFLTEWQVSASADHLGGLRTDATHTLTAYVDGKAVGGDPAAIPLNAHDEIALVYGTAAENAAVSVPSSYNWPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MUX1</accession>
    <name>A0A1E7MUX1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0040300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000099">
        <property type="protein sequence ID" value="OEV32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738044.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6393"/>
    <dbReference type="EnsemblBacteria" id="OEV32250">
        <property type="protein sequence ID" value="OEV32250"/>
        <property type="gene ID" value="HS99_0040300"/>
    </dbReference>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="13">
        <location>
            <begin position="783"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124969" checksum="4A036D41540872CB" modified="2017-01-18" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV92</accession>
    <name>A0A1E7MV92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553809.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000231.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6932"/>
    <dbReference type="EnsemblBacteria" id="OEV32344">
        <property type="protein sequence ID" value="OEV32344"/>
        <property type="gene ID" value="HS99_0016720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046080">
        <property type="entry name" value="DUF6098"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19593">
        <property type="entry name" value="DUF6098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="146" mass="16037" checksum="4FE97E79A50616AE" modified="2017-01-18" version="1">MHSTSGEDGMGLIDDLALLTSLATGDLDVYLRYSEGPDGDGGALSRDYEADVPLPGLSVTPLRPEPWWPRPAADWVARRVMKYAELAESCPQRRPWVLTGRVVGAGPDHEPLIADPLPLAWLGRNVLDEAVRRYQERFTPGRDSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVF3</accession>
    <name>A0A1E7MVF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7013"/>
    <dbReference type="EnsemblBacteria" id="OEV32412">
        <property type="protein sequence ID" value="OEV32412"/>
        <property type="gene ID" value="HS99_0017120"/>
    </dbReference>
    <dbReference type="OMA" id="GNAMHWF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27016" checksum="17EF94C1EF10A7F5" modified="2017-01-18" version="1">MDQNERHLHASSFGAAAAAYAEHRPDYAHAAVRWVLEAAPGLRVLDLGAGTGKLTGVLVGLGAEVVAVEPDPAMLAELRCSQPTVRALSGSAEAIPLPDASVDAVLAGNAMHWFDMAVAGPEIDRVLAPGGILAGLWNVMDDRVAWVADLARVSGPAAVGPRDTPAGWRAATAAAHLPRTGGTARFGSPEQRLFPHGHRRTADSLVATLGTRAGMLVMPEKERKAALDGIRAFLAGRPETAEGEFALPMLTAVLRVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVL5</accession>
    <name>A0A1E7MVL5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GlcNAc-PI de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290104.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1217"/>
    <dbReference type="EnsemblBacteria" id="OEV32470">
        <property type="protein sequence ID" value="OEV32470"/>
        <property type="gene ID" value="HS99_0017470"/>
    </dbReference>
    <dbReference type="OMA" id="TCTDGGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31685" checksum="40DFBEB51357635C" modified="2017-01-18" version="1">MADRPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGACGDGPGGVKPGEDGHDPQAVAALRRKELEASCRVLGVDHLETLDYGDSGMMGWPANDAPGSFWGSPVAEGAARLAELIRHYRPDVVVTYDENGFYGHPDHIQAHRITMAALDLAPDLASKVYWTTAPHSAMKRFGEVMREFGADWDEAGDAAETAEAGEGTDGTSGAGSAVEAPELPPIGLPDEEVTTWVDTSAYGGQKYDALAAHASQGENIFFLRMGKERFTDLMGIETFVRVRDTTGAPLPEQDLFAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW1</accession>
    <name>A0A1E7MVW1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284405.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000926.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79764">
        <property type="protein sequence ID" value="ARF79764"/>
        <property type="gene ID" value="B6264_13385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32564">
        <property type="protein sequence ID" value="OEV32564"/>
        <property type="gene ID" value="HS99_0040075"/>
    </dbReference>
    <dbReference type="OMA" id="MNANLEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="48689" checksum="2072AC805229AB51" modified="2017-01-18" version="1">MNLPELEALAADAYVYGYPLVAGLTMVERFAKGGLGTLPAAPPNHFSHATRLAGPGDQFVSVNNDTIYSIAQLDLSEGPQVLHVPDTSGAYYVLQFIGAWTDNVAYLGSRATGTDAQTWLVVPPDWHGTAPHPDRVIELPTTMGTIVGRFACNGPRDLPRVKALQAGLSLEPLEPGGLVAGLPEPDPDVPERLAFFERLRVWMQAFPPATPDIEYQRRFAPLGLLDDGSSPYRAAAAEWTLALAKGLAAGRERVDAATRPPEEHPLGEWRFALHLFDYNLDHLGPGTLDDPEWRIPDRRAAYLSRAAAARAGLWGNHAYEASYAVTYDDSDGRPLTGAHSYTLHFEQPPPVEAFWSVTMYSVPDYYLVENPINRYSIGNRTPGLVYGPDGSLTVTLQHEPPEDPTAAANWLPTPLGEFRPIMRLYQPKPEVLDGSYQVPPIHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVW6</accession>
    <name>A0A1E7MVW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367093.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7014"/>
    <dbReference type="EnsemblBacteria" id="OEV32413">
        <property type="protein sequence ID" value="OEV32413"/>
        <property type="gene ID" value="HS99_0017125"/>
    </dbReference>
    <dbReference type="OMA" id="KATDICT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198475" evidence="1">
        <location>
            <begin position="31"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="54"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="37938" checksum="C0FE3777686FCE40" modified="2017-01-18" version="1">MNARLRRVIVSTAGLALALSMTAACGKAGGDKKDSAASGDNKSIGLLLPENASSVRYESFDKPFIEAKVKSLCADCKVLYNNAEGSAAKQKQQFDTLIAQGVKVIVLDAFDATSTESWVKEAAAKGVKVVAYDRLATGPVAAYASFDNEKVGELQGQALLDALGPQAPDDNIVMINGDEADPNAAQFKAGAHKILDGKVKKVVYEQSGEWKPTVAGQKIGAAITQLGKDGFQGVYSANDGMAGAIITQLQGAGIKVPVGGQDAGLDAVQRIVNGDQAYTIYKAYKPLADSAAELAVDLLQGKDVKTVATTTVDSSTDKNIPAKLLDAKIVTKANIKDTVIADGLYKATDICTADYAAACTTAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW08</accession>
    <name>A0A1E7MW08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0015150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366547.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3830"/>
    <dbReference type="EnsemblBacteria" id="ARF78349">
        <property type="protein sequence ID" value="ARF78349"/>
        <property type="gene ID" value="B6264_04930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32611">
        <property type="protein sequence ID" value="OEV32611"/>
        <property type="gene ID" value="HS99_0015150"/>
    </dbReference>
    <dbReference type="OMA" id="AFEWVER"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1521" mass="163552" checksum="56A470BB505EACA4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW95</accession>
    <name>A0A1E7MW95_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0015695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557667.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7867"/>
    <dbReference type="EnsemblBacteria" id="ARF78255">
        <property type="protein sequence ID" value="ARF78255"/>
        <property type="gene ID" value="B6264_04390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32706">
        <property type="protein sequence ID" value="OEV32706"/>
        <property type="gene ID" value="HS99_0015695"/>
    </dbReference>
    <dbReference type="OMA" id="PVCLRYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="45711" checksum="F28874A37E732021" modified="2017-01-18" version="1">MTHTFTGLLDTDAIRKDFPVLQRLVHEEKPLVYLDNAATSQKPRQVLEALNAYYERHNANVHRGVHVLAEEATAMYEGARDKVAAFVNAPSRNEVIFTKNASESLNLVANMLGWADEPYKVDADSEIVITEMEHHSNIVPWQLLSQRTGAKLKWFGLTDEGRLDLSNIDELITEKTKVVSFTLVSNLLGTINPVEAIVRRAQAVGALVVIDASQAAPHMVLDVQALEADFVAFTGHKMLGPTGIGVLWGRQELLEDLPPFLGGGEMIETVTMGSSTYAPAPHKFEAGTPPIAQAVGLGAAIDYLSAIGMDRIAAHEHAITEYAVERLLEVPDLRIIGPRTAVDRGAAISFTLGDIHPHDVGQVLDEQGIAVRVGHHCARPVCLRYGIPATTRASFYLYSTPGEVDALIDGLHHVRNFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWN1</accession>
    <name>A0A1E7MWN1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000086">
        <property type="protein sequence ID" value="OEV32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552013.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000090.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1989"/>
    <dbReference type="EnsemblBacteria" id="ARF82781">
        <property type="protein sequence ID" value="ARF82781"/>
        <property type="gene ID" value="B6264_12145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32824">
        <property type="protein sequence ID" value="OEV32824"/>
        <property type="gene ID" value="HS99_0039985"/>
    </dbReference>
    <dbReference type="OMA" id="INQGNDN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="109" mass="10395" checksum="567855889A901C6B" modified="2017-01-18" version="1">MARINPRRASGFLLAVPLAAGLLLAGAGVAAADNGAGAAAGSNAGVVSNNGTGNVFGGVNGNYVSNQQTATGSGASNQNNTLAAKDNAGDILAGQGNKNVNVISTPIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWV7</accession>
    <name>A0A1E7MWV7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03089 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289935.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000519.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene92"/>
    <dbReference type="EnsemblBacteria" id="ARF80112">
        <property type="protein sequence ID" value="ARF80112"/>
        <property type="gene ID" value="B6264_15365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32899">
        <property type="protein sequence ID" value="OEV32899"/>
        <property type="gene ID" value="HS99_0039550"/>
    </dbReference>
    <dbReference type="OMA" id="ATFANWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="27446" checksum="BF84BA9C6A01B706" modified="2017-01-18" version="1">MTAPFAADARTPVELLHAYLRGGTPSVDPAAPLVTFYDDATGERVELSARTFDNWVAKTSNLLQDELNAGPGDRAALLLPAHWQSAVWLLACWSVGVTAVPAGDPAAADLVVSGPDGLEAAQACGGERVALALRPLGGRFPHRPDGFLDYAAEVPGQGDRFAPYSPVAPDGEALETSVDGLPLKLTGEQTVALAREGAVRLGLKPGDRVMSTLSFDDWAGLEAGLLAPLAAGASVVLCRNSQGLDAGQWEKRAESERVTVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX4</accession>
    <name>A0A1E7MWX4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552544.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000500.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81356">
        <property type="protein sequence ID" value="ARF81356"/>
        <property type="gene ID" value="B6264_22780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32946">
        <property type="protein sequence ID" value="OEV32946"/>
        <property type="gene ID" value="HS99_0013760"/>
    </dbReference>
    <dbReference type="OMA" id="QAPNEAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="14726" checksum="FA51E208862CED70" modified="2017-01-18" version="1">MSTQAPNEARVIPLRPQTSPPGSGGTNGTPQAPAPKEPLWRDLIGDVLRRERLAQERTLKDVAEEARISMPYLSELERGRKEASSEVLAAAAKALGLGLGDLLSLAQDELVRHNTRSRSAHRRSAPSARTNGLCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ5</accession>
    <name>A0A1E7MWZ5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5744"/>
    <dbReference type="EnsemblBacteria" id="ARF81379">
        <property type="protein sequence ID" value="ARF81379"/>
        <property type="gene ID" value="B6264_22910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32965">
        <property type="protein sequence ID" value="OEV32965"/>
        <property type="gene ID" value="HS99_0013880"/>
    </dbReference>
    <dbReference type="OMA" id="IDACPCC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="25767" checksum="4F64435099DE6970" modified="2017-01-18" version="1">MVSIMDGTALQDLVNGLPAAFATAPRPTGIDACPCCNAPAGIETLLRTPRERLGPDELTHYATSALSTVGSPGDFRYFAPRILQLVLTGELTVPDLEVVGVKLARAGWYDWPEAGYLRRLLDALWSDALHNAEEWWDAESVLCALAAADPDRTGDRLAEWARLATPTAVERLHELALAGWLEPSNAFRDKQSSAYRALAEWLHGPDLQLAVEAAVFRTDDPAQLEQLFTVHDILAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH1</accession>
    <name>A0A1E7MXH1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0014915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366939.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000537.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33137">
        <property type="protein sequence ID" value="OEV33137"/>
        <property type="gene ID" value="HS99_0014915"/>
    </dbReference>
    <dbReference type="OMA" id="DLACFTV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198525" description="SSI domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="4">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="14763" checksum="B6A51969CD55C7FE" modified="2017-01-18" version="1">MRRITMTVASLLATGAASAILMAGTAQAATTDTVLLGSVHLTKTDSTGTTTSADLSCSAVQGDSGLTSVTGTGTVTSPDAACRELVGFNGDFSKLLVHPTWMVMALQAPVTATAHGSWGATGVNWSHTYVNGSELTKYTGDVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM6</accession>
    <name>A0A1E7MXM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000074">
        <property type="protein sequence ID" value="OEV33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285349.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4420"/>
    <dbReference type="EnsemblBacteria" id="ARF78470">
        <property type="protein sequence ID" value="ARF78470"/>
        <property type="gene ID" value="B6264_05655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33197">
        <property type="protein sequence ID" value="OEV33197"/>
        <property type="gene ID" value="HS99_0039395"/>
    </dbReference>
    <dbReference type="OMA" id="QGWSWQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8378" checksum="E7572AC32E95D0F1" modified="2017-01-18" version="1">MSESGELAAAASSRDPAVGLRAVRALRDLADRLESLQVENARSQGWSWQDIAVCLGVTRQAVHKKYARRTPGKGEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXP7</accession>
    <name>A0A1E7MXP7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleoyl-ACP hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0039290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000073">
        <property type="protein sequence ID" value="OEV33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557706.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7582"/>
    <dbReference type="EnsemblBacteria" id="ARF81765">
        <property type="protein sequence ID" value="ARF81765"/>
        <property type="gene ID" value="B6264_25275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33206">
        <property type="protein sequence ID" value="OEV33206"/>
        <property type="gene ID" value="HS99_0039290"/>
    </dbReference>
    <dbReference type="OMA" id="ALCRLIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="27557" checksum="41ABBBAF3C00A1C1" modified="2017-01-18" version="1">MTSPSTLWLRRFHPAAGRPVRLVCFPHAGGSASYYHPVSAALSADTEVIALQYPGRQDRRTEPCLDSIDALADRITDELLTLEDRPTLYFGHSMGAVLAFETAWRLEQKGGPAPRGIIASGRRAPSTRRAETVHQRDDAGVLAELRLLDGTNTRALENEEILRMSMPAIRADYRAVERYTCEPGRVLRCPITALTGDADPRTTVAEAEAWQEHTNGGFRLRVLPGGHFFLAEQQAAVLREITTELAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS9</accession>
    <name>A0A1E7MXS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554178.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene175"/>
    <dbReference type="EnsemblBacteria" id="OEV33245">
        <property type="protein sequence ID" value="OEV33245"/>
        <property type="gene ID" value="HS99_0038990"/>
    </dbReference>
    <dbReference type="OMA" id="VHDCGTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="225" mass="24460" checksum="64B06BC19B543C6F" modified="2017-01-18" version="1">MTGVRTSRAAVPLVPPPRTVDSRTVDGRGTGARVVRGGVHELSGPGPAALHYPARDLLVVTGLPGSGKSTLMRRCVRAPLVDSQLVRQEYAARLPGRLPYALYRPLVRLAHYRRLRRAVLDGGPLAVHDCGTLPFVRAWLTRAAERQGRRVHLLLLDADPAEAMAGQRRRGRRVSRYAFARHRRAVARLRLLLLGAGRAPAGCASAVVLDRGAARALREIDFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXV6</accession>
    <name>A0A1E7MXV6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552414.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5617"/>
    <dbReference type="EnsemblBacteria" id="OEV33073">
        <property type="protein sequence ID" value="OEV33073"/>
        <property type="gene ID" value="HS99_0014510"/>
    </dbReference>
    <dbReference type="OMA" id="TYDAWAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="82"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="27714" checksum="929F2E999E1D1C0D" modified="2017-01-18" version="1">MSNTRKTDQKTNATERMRAARAQAERSDRIRRRVVVGGASAAVLALAAGVAFAVGGSSGSSSDAAASGPLVAPANTTGPDGTVITYGKADAPHTLEIYEDFRCPFCEQLETTTGKSVQQLADNGTYKIEYHLATFLDKNLGGKGSRTALAAAGAALNEGVDKFKAFHDVLYANQPDERSDAFGDVNHILDLAGQVPGLKTDGFVKAVQEGTYAPWAAKVNEEFNKSDVTGTPTVKLDGKKLDVLTNGKAASPDEFTAMVKQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY09</accession>
    <name>A0A1E7MY09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7034"/>
    <dbReference type="EnsemblBacteria" id="ARF80426">
        <property type="protein sequence ID" value="ARF80426"/>
        <property type="gene ID" value="B6264_17275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33325">
        <property type="protein sequence ID" value="OEV33325"/>
        <property type="gene ID" value="HS99_0012045"/>
    </dbReference>
    <dbReference type="OMA" id="TEWNVAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23488" checksum="8FA721A7E340A214" modified="2017-01-18" version="1">MSRDARGPRIVFWRHGQTSWNLESRFQGTTDIELTGQGVLQAQRAARLLSGLRPDLLISSDLKRARRTAEELAAVTGLDVQHHEGLRETYAGSWQGLTNAEIRERYPEEYAAWAAGEPVRRGGGELSTEVADRSVPVVLEAVAKLPENGTLVVVSHGGTIRTMLGRLLGLEPPVWECFGGLSNCCWSVLGKGARGWRLLEHNAGTLPQPVIGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY43</accession>
    <name>A0A1E7MY43_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0012205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000453.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000088_gene3392"/>
    <dbReference type="EnsemblBacteria" id="ARF80453">
        <property type="protein sequence ID" value="ARF80453"/>
        <property type="gene ID" value="B6264_17435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33352">
        <property type="protein sequence ID" value="OEV33352"/>
        <property type="gene ID" value="HS99_0012205"/>
    </dbReference>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="249" mass="25708" checksum="30EFA5CD16994DB4" modified="2017-01-18" version="1">MTAPVFVVETERIAAAAPGAVVRLDGAEGRHAAAVKRLTAGEAVTLADGLGLGVDGTVAEVLGKDAIDVTVDAVRREAEPAPRIVVVQALPKGDRGELAVETMTEVGVDVVVPWAASRCITQWKGERGAKALAKWRATAREAGKQSRRLRFPEVRELMTTRQLAPLLAQAALAAVLHEEGAEPLAQAALPAGGDIVLVVGPEGGVSPEELAAFAEAGARPYRLGPSVLRTSTAGVAAGALLLGRTGRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY49</accession>
    <name>A0A1E7MY49_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="9" type="ORF">HS99_0012230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290761.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4042"/>
    <dbReference type="EnsemblBacteria" id="ARF80457">
        <property type="protein sequence ID" value="ARF80457"/>
        <property type="gene ID" value="B6264_17460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33356">
        <property type="protein sequence ID" value="OEV33356"/>
        <property type="gene ID" value="HS99_0012230"/>
    </dbReference>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33636" checksum="44A6D702EF609AFA" modified="2017-01-18" version="1">MSQRELVVLGTASQVPTRHRNHNGYLLRWDGEGLLFDPGEGTQRQMLRAGVSATQITRIAVTHFHGDHCLGLAGVIQRINLDRVPHPVDVYFPASGEVYFERLRHATAYHETAVLRPRPIDEPGPLPAPGARFALDAVRLDHPVESFGYRLSEPDGRRLVPERLAASGVHGPAVGRLQHEGAIEVDGRTVTLDEVSEPRPGQRFAFVMDTRLCDGVHELAEGADLLVVEATFADADAQLAEDHGHLTAGQAAKAAAEAGVRTLVLTHFSQRYPDLGQHLADARKHFDGELVLAEDLARVPVPARRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU0</accession>
    <name>A0A1E7MYU0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553434.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3982"/>
    <dbReference type="EnsemblBacteria" id="ARF80507">
        <property type="protein sequence ID" value="ARF80507"/>
        <property type="gene ID" value="B6264_17765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33403">
        <property type="protein sequence ID" value="OEV33403"/>
        <property type="gene ID" value="HS99_0012540"/>
    </dbReference>
    <dbReference type="OMA" id="RLDHNIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="51822" checksum="494719D5508078B5" modified="2017-01-18" version="1">MSSSTRRRRYLRTAIGLAAVLVLSVVGAGAWFYHRLDSNITTFSAAGVATERPPAPVPASPGAQVPVNVLLLGSDTRDDGNNSLGGGDEGVGNSDTAILVHVYADHKHAVGVSIPRDTLVTIPSCKLADGTWSKPRNDQMFNSAFSLGELPKGNPACTQNTVEKLTGLRVDHTIVVDFKGAAAMTDAIGGVQACVPNDVNEYGIQLKKGLQNLSGKSAVDYLRARHGIGDNSDIGRMKRQQAFLSSMIKKVQDQGFSLPTLLPLADAATKSLTVDEGLGTAMKLVDFARSLEDIKLSDVTFVTAPWRFAGDRVRLVQPDADDLWKLLREDRTLDGHSTAGTGAATASASASASPSANAPLTPDQAAAPITVVNGVGTAGLAGSGAETLKGRGFQNVVLGANQPGKQHTEVSYDPALKATADQVAALFPGARTVEEAGSGAVTVTLGADYQAAGTQLNSVSSPSATPGGAPTAAPSTAPSGVPTGIAENTRGADTDPCADLTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYU7</accession>
    <name>A0A1E7MYU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282538.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000357.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5186"/>
    <dbReference type="EnsemblBacteria" id="ARF82910">
        <property type="protein sequence ID" value="ARF82910"/>
        <property type="gene ID" value="B6264_18410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33607">
        <property type="protein sequence ID" value="OEV33607"/>
        <property type="gene ID" value="HS99_0013190"/>
    </dbReference>
    <dbReference type="OMA" id="GPECPAK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="76" mass="8762" checksum="6C48C97C8BA6F168" modified="2017-01-18" version="1">MPLGFHRKPTGRPGEWFYCIKHGKVEEGPECPAKDRLGPYATPDEAAHALETADERNREWQNDPRWTDQPKDEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ00</accession>
    <name>A0A1E7MZ00_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0038600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33657">
        <property type="protein sequence ID" value="OEV33657"/>
        <property type="gene ID" value="HS99_0038600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="12">
        <location>
            <begin position="41"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="417" mass="41592" checksum="97FE6393602BCE2C" modified="2017-01-18" version="1">MAAGVVVGPVAAPAVAEDTIRQQQWHLEAMHAPEMWKTSKGQGITVAVIDGGFKLDHPDLEGQFLPGKDFSGSPGGVGSYVDGHGTEMASLIAGTGKSSGGTGAYGLAPGAKILPLKMNDGSDRSLGASISSDFLDEVGQAVNYAVDQGAKVISISEESAAVTATPENVAKLNRILAAARAKGVLVVASVGNSAKDGNLVMYPAALPNVVGVGAVDRNGTVTEESQTGPHVAFVAPGIDVVDACTGTTGYCKRHGTSAAAALVSASAALVWAVHKEWTANQVLRVLINTAGRPNDGNSRTNSAGWGAVRPRIALTNPGDPGPADVSPLPGDVPVPTPSSALMASPLPTATPAGPSPTVASSTGGSSSAAVAAVDTGGVNAGLSWPVAIAVIVVVVVAAGVIVALLVRRLIVVLRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ36</accession>
    <name>A0A1E7MZ36_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">HS99_0038385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289915.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000169.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4286"/>
    <dbReference type="EnsemblBacteria" id="ARF80358">
        <property type="protein sequence ID" value="ARF80358"/>
        <property type="gene ID" value="B6264_16855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33696">
        <property type="protein sequence ID" value="OEV33696"/>
        <property type="gene ID" value="HS99_0038385"/>
    </dbReference>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="30897" checksum="4E4FCDAD0BFC6C5C" modified="2017-01-18" version="1">MAPTSTPQTPFGRVLTAMVTPFTADGALDLDGAQRLATHLVDSGNDGLVVNGTTGESPTTSDAEKAQLVRAVVEAVGDRAHVVAGAGTNDTHHSVELARQAEAAGAHGLLVVTPYYNKPPQEGLYRHFTQVADATGLPVMAYDIPGRSGVALSHETLVRLGEHPRIVANKDAKGDLGAAAWAIARSDLAWYSGDDILNLPLLSVGAVGVVSVVGHVVAGELKSMIEAYLGGDVAKATAIHQGLLPVFTGMFRTQGVILSKAALDLQGLPAGPLRLPLVGATPEEIDRLKQDLAAGGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA0</accession>
    <name>A0A1E7MZA0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282652.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000309.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80657">
        <property type="protein sequence ID" value="ARF80657"/>
        <property type="gene ID" value="B6264_18655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33553">
        <property type="protein sequence ID" value="OEV33553"/>
        <property type="gene ID" value="HS99_0013435"/>
    </dbReference>
    <dbReference type="OMA" id="GEYWPTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8453" checksum="36F4765FF2105C09" modified="2017-01-18" version="1">MRTTPLVLDLELCGGRWDGHRKRVNAAAPPPALRMVLRAELPVAENGEYWPTTSVYRLDEENGAALRYRYSHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC0</accession>
    <name>A0A1E7MZC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366788.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000580.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4515"/>
    <dbReference type="EnsemblBacteria" id="ARF80373">
        <property type="protein sequence ID" value="ARF80373"/>
        <property type="gene ID" value="B6264_16970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33795">
        <property type="protein sequence ID" value="OEV33795"/>
        <property type="gene ID" value="HS99_0037600"/>
    </dbReference>
    <dbReference type="OMA" id="QCMEAID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046081">
        <property type="entry name" value="DUF6099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19594">
        <property type="entry name" value="DUF6099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="209" mass="21458" checksum="F63F67FC090D6716" modified="2017-01-18" version="1">MEALRLIKTARHALAEARQVPDVLGEARQVALLTEAVGARLAESEDEELTGLGQQLSEAGAHAAVCLDRSVADGTPVSGGRAGRLTELGELQPTLEALDGLLRDVGETLVVLACGADTESLYWTCIDGVDAMSECKDVTARLREAVDRGGGVERTALGGAEPERAGGGSPLLVVRLGPPGEGGPTEEERAPDYRVPAAVGASEVSVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZL8</accession>
    <name>A0A1E7MZL8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6362"/>
    <dbReference type="EnsemblBacteria" id="ARF78763">
        <property type="protein sequence ID" value="ARF78763"/>
        <property type="gene ID" value="B6264_07385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33861">
        <property type="protein sequence ID" value="OEV33861"/>
        <property type="gene ID" value="HS99_0037260"/>
    </dbReference>
    <dbReference type="OMA" id="DRYKFVA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="29037" checksum="31B1C575313223D9" modified="2017-01-18" version="1">MSSDGGTTAQADDPEVRNLPTQSADPTARVPKYYGLKRHLLQLTETQPAGTPVPPERALAAQFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVAQALQLTSYTEDMRAQGLEPTSRLIEIGYITADDRLAPLLDIKPGGRVLRIERLRLANGDPMAIEVAHLSAKRFPSLRRNLAKHNSLYAALREVYGVTVAEAEETIETTLANPREAGLLGSDLGLPMLQLSRHSFDGEGDPVEWVRSIYRGDRYKFITRLKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZN9</accession>
    <name>A0A1E7MZN9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552240.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000363.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1842"/>
    <dbReference type="EnsemblBacteria" id="ARF77751">
        <property type="protein sequence ID" value="ARF77751"/>
        <property type="gene ID" value="B6264_01360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33908">
        <property type="protein sequence ID" value="OEV33908"/>
        <property type="gene ID" value="HS99_0010520"/>
    </dbReference>
    <dbReference type="OMA" id="AHGWTCS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="35677" checksum="ED543CBE15A833B6" modified="2017-01-18" version="1">MSSVQLPADYVPPTPVEELGIRSADGIRLHVEVHGRPGAPTVVLSHGWTCSTAFWAPVIRQLADRYRVVVYDQRGHGRSEIPPSRARYSTRALAEDLATVLARTVPAGERAVLAGHSMGGMTIMAAGGRPEVAERTAANVLISTGPSELVAELTVLSDVVRAPGLRRFLHRRLLRSRMPLGPVSAVSRAALKYATMGPSSPAGQVEATARIVHACPAAVRFHWAGVLDRLDVRAGLGRVTAPTAVVVGTADRLTPPVHAHRIVAELADPQGLLLLPGVGHMAPLERPVEVAAEIHRMAAAHLTGAASDAASAAASAAASVDAPAAASVPAPVAVPVVERTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZR9</accession>
    <name>A0A1E7MZR9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366463.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000367.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1887"/>
    <dbReference type="EnsemblBacteria" id="ARF77790">
        <property type="protein sequence ID" value="ARF77790"/>
        <property type="gene ID" value="B6264_01585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33938">
        <property type="protein sequence ID" value="OEV33938"/>
        <property type="gene ID" value="HS99_0010745"/>
    </dbReference>
    <dbReference type="OMA" id="AGVLYHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="25773" checksum="6F0D2967EAEB3591" modified="2017-01-18" version="1">MSLGNALRAERIKFSTLPSQWAAPLTAVALTVGVTAAVNAAYGAKDHTPGEDPAGGIYYGLLFGHVAVACLGILLVGQEFNTRMIGTSLTAVPRRGRLYGAKVSLGAGLGLLVGLASTAGCFLTVDATVGLDFSTPGLARSFLAGVLYHPMMVLICLGLTAMLGNFSVALGLLTPMVFLGTTWLAAIPGVREVGQFLPDRAGLYAMRTQTEAGIHYGHWTGLLIMALWTAAAVFGGLRAMRRYQASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZX3</accession>
    <name>A0A1E7MZX3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0011075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033349202.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000762.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2221"/>
    <dbReference type="EnsemblBacteria" id="ARF77848">
        <property type="protein sequence ID" value="ARF77848"/>
        <property type="gene ID" value="B6264_01920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33990">
        <property type="protein sequence ID" value="OEV33990"/>
        <property type="gene ID" value="HS99_0011075"/>
    </dbReference>
    <dbReference type="OMA" id="QATCVRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20328" checksum="B3A845B239CE8072" modified="2017-01-18" version="1">MDDDQLTALALTARSGRAADVEAFVRATQRDVWRFVAHLTDVQSADDLAQETFLRALRGLPAFAGRSSARTWLLSIARRTVIDRYRMAAARPRCAALPDWQEAAERQSSTPTAGFEDGIALGDLLERVPAQRREAFVLTQVVGLTYAEAAEVAGCPVGTVRSRVARAREELMARLRAAEAGELAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZX5</accession>
    <name>A0A1E7MZX5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280208.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000411.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2235"/>
    <dbReference type="EnsemblBacteria" id="ARF77855">
        <property type="protein sequence ID" value="ARF77855"/>
        <property type="gene ID" value="B6264_01980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33997">
        <property type="protein sequence ID" value="OEV33997"/>
        <property type="gene ID" value="HS99_0011135"/>
    </dbReference>
    <dbReference type="OMA" id="YEMNVLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="144" mass="15304" checksum="900ACBCA42200726" modified="2017-01-18" version="1">MTQQQTETQRDLNWLLDQLVARVPETRHAIVLSEDGLLVGMSQGLDRADAEHLSAVASGLQSLARGAGHRFNGGRVRQTVVEMDQLFLFVTTAGQGARLAVLTSEQVDAGLMAYEINMLVKQVGQYLTAAPRSDAGQVGAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZY9</accession>
    <name>A0A1E7MZY9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366473.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000411.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2234"/>
    <dbReference type="EnsemblBacteria" id="ARF77854">
        <property type="protein sequence ID" value="ARF77854"/>
        <property type="gene ID" value="B6264_01975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33996">
        <property type="protein sequence ID" value="OEV33996"/>
        <property type="gene ID" value="HS99_0011130"/>
    </dbReference>
    <dbReference type="OMA" id="THERPQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="723" mass="73802" checksum="2574969DE566335F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N064</accession>
    <name>A0A1E7N064_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2325"/>
    <dbReference type="EnsemblBacteria" id="ARF77930">
        <property type="protein sequence ID" value="ARF77930"/>
        <property type="gene ID" value="B6264_02425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34072">
        <property type="protein sequence ID" value="OEV34072"/>
        <property type="gene ID" value="HS99_0011575"/>
    </dbReference>
    <dbReference type="OMA" id="DIFLGWM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="49340" checksum="85D9EF7C9C736D9C" modified="2017-01-18" version="1">MTTPAERRRTGRTARERVSRSEHGRWIPAADRPDPLGVLEAQGADRVARLLPIRYGRMADSAFSYLRGAAAVMAADLAAVPDTGLTVQLCGDAHLVNFGVYASPERALLFDVNDFDETHPGPFEWDVKRLAASVAVAARDAGQDDRCARRAARAAVQGYATAMRRLAGLGELDVWYSRIDTADLLPLIRKKGRRKAVEEGLAHARRRTSLQALGKLTEERDGRRRIISSPPLVEELSKSELRSLGLVFSDYRASLAEDRRVLLGRYRFVDAAMKVVGVGSVGTRCYIVLLEGRDSSDPLFLQLKEAGRSVLEDHLPRTRVDAEVAVHHGGRRVVTGQHLMQAASDIFLGWTIGPAGRHFYGRQLRDMKGAVEVGALTPSGLRAYADLCGRTLARAHARTGDRLAVAGYLGAADTFAEAVADFALRYADRTAADHRELVEAIESGRITAARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0H4</accession>
    <name>A0A1E7N0H4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386653.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2202"/>
    <dbReference type="EnsemblBacteria" id="ARF77831">
        <property type="protein sequence ID" value="ARF77831"/>
        <property type="gene ID" value="B6264_01825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33973">
        <property type="protein sequence ID" value="OEV33973"/>
        <property type="gene ID" value="HS99_0010980"/>
    </dbReference>
    <dbReference type="OMA" id="RTHSMAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005530">
        <property type="entry name" value="SPW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03779">
        <property type="entry name" value="SPW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="157" mass="16441" checksum="5B99FC3CA2D7F6FC" modified="2017-01-18" version="1">MEHHPDIVELREHYERVTSTPRAQGIEALAVLAGLFLAASPWIVGFTAFSTLTVTCLIVGLAYTALMAGYGPAYERTHARAWAAAALGVWTIISPWVVSGSVAHGKNIVTCVIVGAVMFLLGLAAISMATITANGAAMRLGRAGRADRTGRAGHVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0I7</accession>
    <name>A0A1E7N0I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278480.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000575.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1976"/>
    <dbReference type="EnsemblBacteria" id="ARF79578">
        <property type="protein sequence ID" value="ARF79578"/>
        <property type="gene ID" value="B6264_12225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34192">
        <property type="protein sequence ID" value="OEV34192"/>
        <property type="gene ID" value="HS99_0037075"/>
    </dbReference>
    <dbReference type="OMA" id="EWLLFRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="53971" checksum="6474DCBE83DAA31C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q7</accession>
    <name>A0A1E7N0Q7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386008.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000190.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2585"/>
    <dbReference type="EnsemblBacteria" id="OEV34280">
        <property type="protein sequence ID" value="OEV34280"/>
        <property type="gene ID" value="HS99_0036765"/>
    </dbReference>
    <dbReference type="OMA" id="MWRIGRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12597" checksum="7D42AF135187D655" modified="2017-01-18" version="1">MIEHRVLLGVRAAWGSLLLVRPSYVCTVLAGRPPDTVTCATAGVLGVRHLARAALTPRLGPRGAPAGAATGLAHALSMPVLATVVPDRRRICLTDAASATAFCLADTERFGRAAATAARGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0U2</accession>
    <name>A0A1E7N0U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000200.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78497">
        <property type="protein sequence ID" value="ARF78497"/>
        <property type="gene ID" value="B6264_05825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34295">
        <property type="protein sequence ID" value="OEV34295"/>
        <property type="gene ID" value="HS99_0036555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10887" checksum="A4CAA13281D36581" modified="2017-01-18" version="1">MRRIATVRTVARIRLRVRWAVTRPARRVLLVLTAGLTWWLVAVRGQLTDGAVLGLLAAGGWGLGLIPVHADRNATGPVRRRRGREEAVRRVEAPSPPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W0</accession>
    <name>A0A1E7N0W0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0036330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386362.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000332.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6398"/>
    <dbReference type="EnsemblBacteria" id="ARF78733">
        <property type="protein sequence ID" value="ARF78733"/>
        <property type="gene ID" value="B6264_07205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34319">
        <property type="protein sequence ID" value="OEV34319"/>
        <property type="gene ID" value="HS99_0036330"/>
    </dbReference>
    <dbReference type="OMA" id="NREWSFK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="20236" checksum="1DF3844F2189C262" modified="2017-01-18" version="1">MPSPTQRVLARVPARLRPFLVRHRRPVKFLLVGSGCFVLTTVIDLELKLTVLEHKPVVALTVATVIATAASYVLNRRWAFRTDGRRPEALLFFLVSVVAVGVNVVPLALSRYAFRLREPYVTPFQQEIADFLSGMVLGTFVAMLFRYWAMRRWVFTSPLAGTHTGPEPGYAAPEMPRDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1D1</accession>
    <name>A0A1E7N1D1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557419.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7071"/>
    <dbReference type="EnsemblBacteria" id="OEV34497">
        <property type="protein sequence ID" value="OEV34497"/>
        <property type="gene ID" value="HS99_0035455"/>
    </dbReference>
    <dbReference type="OMA" id="CREEWPI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="17752" checksum="1C566F52A8439C47" modified="2017-01-18" version="1">MPDSRPPTARGPAPEGTADRTDYAGAVYGSMLAASVIAASGVHETRPRLSLILLLVVNGLVFWVAHVYAHLAGEREVGRRVGWHRVREVGREEWPLVEASALPALAVLVSPWLGTGDSAWLAVGVAVAQQVGWATLGARRAGASTGQAAVEGVVNLLLGLCIVAAKVAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1L5</accession>
    <name>A0A1E7N1L5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0008790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558219.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000101_gene7494"/>
    <dbReference type="EnsemblBacteria" id="ARF82047">
        <property type="protein sequence ID" value="ARF82047"/>
        <property type="gene ID" value="B6264_27005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34589">
        <property type="protein sequence ID" value="OEV34589"/>
        <property type="gene ID" value="HS99_0008790"/>
    </dbReference>
    <dbReference type="OMA" id="EMTHGVV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FTP" evidence="9">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="7">
        <location>
            <begin position="259"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="8">
        <location>
            <begin position="416"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="921" mass="95344" checksum="1970B222B6999F56" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1W3</accession>
    <name>A0A1E7N1W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81962">
        <property type="protein sequence ID" value="ARF81962"/>
        <property type="gene ID" value="B6264_26490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34674">
        <property type="protein sequence ID" value="OEV34674"/>
        <property type="gene ID" value="HS99_0009290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="93" mass="9501" checksum="A75DCF576DB993F0" modified="2017-01-18" version="1">MMGRGEVARVEEQADEAADGDGQRYRAVTAGSGAPFASLCARMAVRQERTAAEAEAPGRATVLLVPSCGKGKAAGRSADRLRCAPVPGARVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1X4</accession>
    <name>A0A1E7N1X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558279.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000535.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81954">
        <property type="protein sequence ID" value="ARF81954"/>
        <property type="gene ID" value="B6264_26440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34682">
        <property type="protein sequence ID" value="OEV34682"/>
        <property type="gene ID" value="HS99_0009340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11457" checksum="AB5EED8650EC3792" modified="2017-01-18" version="1">MSSSRAVSREVVQSIVDAVAQLDRDALRRLDPEGLSAQFDARFELEDYFHAMWEHLKACGERPAVRVEYQPLAALLDLLTGLSENVMFVDSVVHKDVLRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z2</accession>
    <name>A0A1E7N1Z2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0035375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000260.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7055"/>
    <dbReference type="EnsemblBacteria" id="OEV34483">
        <property type="protein sequence ID" value="OEV34483"/>
        <property type="gene ID" value="HS99_0035375"/>
    </dbReference>
    <dbReference type="OMA" id="WIAHATI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="237"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42228" checksum="6B9105D1BCD01895" modified="2017-01-18" version="1">MTPNAFDPEILRLPFYTDEHRDRAQRLGRWCEERAALWTELRTDGPDKAVRRALAALGEAGWLAFLDDEEPGTDGDYRSVCLAREALAYAEDLADFAFAIQVLSATPILRYGSPEQRRRYLPGLAAGTLAGAFAVSEEQSGSDVAAVALTAERDGEEYVLNGGKAWIANGTVADVVCVIARTGEGPGPLGLTAFLVPGDTPGLRVREPIDAIAPRPFAHLAFEDCRVPADAVLGRPGRGFVVAMDLLERARMTVGAAALGFARRAADAAQARARQRAIYGGVLFDLPTVKFDLAAMEVELNASALLVGRAAWELDRGHRGFGKHSSIAKLQATEAAQRIVDRCVQLHGAAGLVADSLPERLYRQIRALRVYEGASEVQQLTIAGALDARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N263</accession>
    <name>A0A1E7N263_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555790.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4577"/>
    <dbReference type="EnsemblBacteria" id="OEV34779">
        <property type="protein sequence ID" value="OEV34779"/>
        <property type="gene ID" value="HS99_0009880"/>
    </dbReference>
    <dbReference type="OMA" id="HDHQGTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26533" checksum="85A73814712877FB" modified="2017-01-18" version="1">MDLSNRTVLVVGGTSGIGRELARRFAAAGSTVAIGGRNPQALTELAEEGFGTISIDVTSSASVASARDAALARYPELDTVVTMSGVMLLEDLRDPAHFEAAATTVDTNLLGTIRVVDAFTPHLIRRGAGTFVTVTSGIAFLPFPPMPSYAASKAGVHAYSEALRAQLDGTGVGVVELVPPAVATASQEKVNPHALPLDDFATEVMDLLSQDPTPREILVKGVLGHRWAEREGTYDDLVAQRSQALAMLPGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R0</accession>
    <name>A0A1E7N2R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290421.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4563"/>
    <dbReference type="EnsemblBacteria" id="ARF78516">
        <property type="protein sequence ID" value="ARF78516"/>
        <property type="gene ID" value="B6264_05960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34981">
        <property type="protein sequence ID" value="OEV34981"/>
        <property type="gene ID" value="HS99_0034800"/>
    </dbReference>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="452" mass="48250" checksum="74F2F9B0A443D30C" modified="2017-01-18" version="1">MSIPTADSAAGQAVKAADRAHVFHSWSAQALIDPLAVAGAEGSYFWDYDGNRYLDFSSQLVNTNIGHQHPKVVAAIQEQAAKLCTIAPGFAVESRSEAARLIAERTPGDLDKIFFTNGGAEAVENAIRLARLHTGRQKVLSTYRSYHGATANAIALTGDPRRWANETGVSGVVHFWGPYAYRSNFHAENEAQECERALEHLEQVIAFEGPGTVAAVILETVVGTAGVLVPPPGYLAGVREICDRYGIVFILDEVMAGFGRTGEWFAADHWGVVPDLMTFAKGVNSGYVPLGGVAISAEIAATFAERPFPGGLTYSGHPLACASAVATINAMAEEGIVENAKHIGETVLGPGLRELAERHPSIGEVRGLGVFWALDLVKDRETREPLVPYNAAGADNAPMAELAAACKQRGLWPFVNMNRFHVVPPCTVTEEEAKAGLAVLDEVLSLTDAHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S7</accession>
    <name>A0A1E7N2S7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-aminobutyraldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386607.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000427.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000082_gene4564"/>
    <dbReference type="EnsemblBacteria" id="ARF78517">
        <property type="protein sequence ID" value="ARF78517"/>
        <property type="gene ID" value="B6264_05965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34980">
        <property type="protein sequence ID" value="OEV34980"/>
        <property type="gene ID" value="HS99_0034795"/>
    </dbReference>
    <dbReference type="OMA" id="GMKYVTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07092">
        <property type="entry name" value="ALDH_ABALDH-YdcW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015657">
        <property type="entry name" value="Aminobutyraldehyde_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="497" mass="53280" checksum="282B9788E22336CD" modified="2017-01-18" version="1">MAPESATPQAQTEERPVSDLRTLRNYINGEFVDAADGRTLDIVDPTTGEVYATSPLSGAADVDAAMASAAAAFPVWRDATPSTRQKLLLKIADAIEARADEIVDAEVRNTGKPRALTLSEEIGPMVDQIRFFAGAARLLEGKAAGEYMDGMTSIIRREPVGVCAQVAPWNYPMMMAVWKFAPAIAAGNTVVLKPSDTTPASTVLLAEIIGGILKDLELPVGVFNVICGDRETGRLMVEHRTPAMASITGSVRAGIQVAESASKDVKRVHLELGGKAPVVVFEDADIAEAVEGISVAGYFNAGQDCTAATRVLVHESIHDAFVEALAKAAAETKTGGVDDEDVLYGPLNNANQLKQVAGFIERLPAHAKVEAGGHRVGDKGYFYAPTVVSGLNQDDEIIQNEVFGPVITVQKFTDEDQAVEYANGVEFALASSVWTKDHARAMRMSRRLDFGCVWINTHIPLVAEMPHGGFKKSGYGKDLSSYGFEDYTRVKHVMTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N352</accession>
    <name>A0A1E7N352_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554302.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene393"/>
    <dbReference type="EnsemblBacteria" id="ARF78907">
        <property type="protein sequence ID" value="ARF78907"/>
        <property type="gene ID" value="B6264_08245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35104">
        <property type="protein sequence ID" value="OEV35104"/>
        <property type="gene ID" value="HS99_0034155"/>
    </dbReference>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="44518" checksum="2726B992DA880AC8" modified="2017-01-18" version="1">MQVIQSSKLANVCYDIRGPVLDEAMRLEEQGHRILKLNTGNPATFGFEAPPEILQDILRNLANAHGYGDSKGLLSARRAVVMHYEDRGLHGLSVDDVFLGNGVSELIQLAMTALLDDGDEVLVPAPDYPLWTASVSLAGGTAVHYRCDEQAEWYPDLADIEARITDRTRAIVVINPNNPTGAVYPREVLEGIVEIARRHKLVVYADEIYDKILYDDAEHVPLATLAPDLFCVTFNGLSKSYRVAGFRSGWMVLSGDRQPARSYIEGLTVLASMRLCANMPAQHAVAAALGGRQSIKDLVLPGGRLLASRDAAHELLNQIPGVSCVKPKGALYAFPRLDPKVYKIRDDAQMVLDLLRSQRILLVQGTGFNWPEPDHFRLVTLPRPEEITEAVTRIGDFLSGYTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P1</accession>
    <name>A0A1E7N3P1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554345.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000435.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene431"/>
    <dbReference type="EnsemblBacteria" id="ARF78874">
        <property type="protein sequence ID" value="ARF78874"/>
        <property type="gene ID" value="B6264_08055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35073">
        <property type="protein sequence ID" value="OEV35073"/>
        <property type="gene ID" value="HS99_0033960"/>
    </dbReference>
    <dbReference type="OMA" id="CECGQEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24029" checksum="23DD2DF76DECC963" modified="2017-01-18" version="1">MPGPGQRPFVLLSAAVSLDGHLDDASPDRLLLSNAADFDRVDEERAAADAVLVGGNTLRADNPRLLVNDPARRAARLAAGRPEYPLKVTLSASGALDAGLRFWHTGGAKLAYTTEAGAAVLRPRLDGLSEVVALSGSVDLGAVLDDLGARGVRRLMVEGGGGVHTQFLARGLADELQLAVAPLLVGQAEAPRFVRPAAFPGGPGRRMRLLEARTVGDVVLLRYAPKEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N462</accession>
    <name>A0A1E7N462_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0032405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283403.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3891"/>
    <dbReference type="EnsemblBacteria" id="OEV35462">
        <property type="protein sequence ID" value="OEV35462"/>
        <property type="gene ID" value="HS99_0032405"/>
    </dbReference>
    <dbReference type="OMA" id="TVPQEWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032610">
        <property type="entry name" value="DUF2172"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032589">
        <property type="entry name" value="DUF4910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012353">
        <property type="entry name" value="UCP015244"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032622">
        <property type="entry name" value="UCP01524_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09940">
        <property type="entry name" value="DUF2172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16254">
        <property type="entry name" value="DUF4910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16221">
        <property type="entry name" value="HTH_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015244">
        <property type="entry name" value="UCP015244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF4910" evidence="4">
        <location>
            <begin position="12"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2172" evidence="2">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_47" evidence="3">
        <location>
            <begin position="351"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015244-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="47001" checksum="343BB76516BB1190" modified="2017-01-18" version="1">MAPVTTVGEEMHALVERLYPLCRSITGDGVRATLEIVGEYLPLRVHEVPTGTQVLDWTVPQEWNIRDAYIADATGRRVVDFAASSLHVVGYSVPVAATVPLAELRRHLHTLPDHPSWVPYRTSYYTADWGFCLAQDTLDALPDGDYEVRIDSTLADGHLTYAEHVVPGQVADEVIVSCHVCHPSLANDNLAGIAVATFLARELAQRTPYHTYRFLFAPGTIGAITWLARNAERVERVKHGLVLACAGDRGQLTYKQSRRGDAEIDRVLRHVLAASGRPHRITEFTPYGYDERQFCSPGFDLGVGSLSRTPYAGYPEYHTSADNPDFVRPEAMADTLAVCREAFSLLDRNRSYLNLSPYGEPQLGRRGLYDSLGGRSDAKEAQMAMLWVLSLSDGRHSLLDVAERSGLPFDTVAVAADALRGAGLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R6</accession>
    <name>A0A1E7N4R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281704.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene883"/>
    <dbReference type="EnsemblBacteria" id="ARF80888">
        <property type="protein sequence ID" value="ARF80888"/>
        <property type="gene ID" value="B6264_19990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35688">
        <property type="protein sequence ID" value="OEV35688"/>
        <property type="gene ID" value="HS99_0007215"/>
    </dbReference>
    <dbReference type="OMA" id="RAAPFYC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="59" mass="6578" checksum="A72525447BDCCBE7" modified="2017-01-18" version="1">MSERAAPFFCPYCGDEDLRPSEAGHGAWECHGCRRAFQLKFLGLLSPTNGGTSHEQHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4W3</accession>
    <name>A0A1E7N4W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281563.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene817"/>
    <dbReference type="EnsemblBacteria" id="ARF80941">
        <property type="protein sequence ID" value="ARF80941"/>
        <property type="gene ID" value="B6264_20325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35737">
        <property type="protein sequence ID" value="OEV35737"/>
        <property type="gene ID" value="HS99_0007555"/>
    </dbReference>
    <dbReference type="OMA" id="LFRYFPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="23161" checksum="189B1A707E728E85" modified="2017-01-18" version="1">MARMSGLRELKKERTRRAISEAAIALFLEHGFDQVSVADVAAAAEVSKPTLFSYFGSKEDLVVHRFADHQEQAADVVRGRGEGETVLDALRRDFLDGLARRDPVTGLNDHPQVLAFTSLVYGTPSLAARVGAYVARAERSLADALREAPDLAPPRELTAQLLAAQVTATQRVLALHNWRRIHEGGRTADDLHPEAAADADRAFELLARGYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y6</accession>
    <name>A0A1E7N4Y6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5493"/>
    <dbReference type="EnsemblBacteria" id="OEV35523">
        <property type="protein sequence ID" value="OEV35523"/>
        <property type="gene ID" value="HS99_0032005"/>
    </dbReference>
    <dbReference type="OMA" id="VTWAFGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="14908" checksum="B025096D5325AB5B" modified="2017-01-18" version="1">MQHSTVQGRLVMNLVVSPELSFGIVADLAYEPTDPYAVRFAFNLPGDAPVTWVFARELLLDGLGGPSGEGDVHIHPLDGEPSEVRIALHSPHGDAVLHAPAAPLIAFLARTDRLVPMGQERIGRELDARLAEILGGCDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N568</accession>
    <name>A0A1E7N568_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286104.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3354"/>
    <dbReference type="EnsemblBacteria" id="ARF81052">
        <property type="protein sequence ID" value="ARF81052"/>
        <property type="gene ID" value="B6264_21005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35841">
        <property type="protein sequence ID" value="OEV35841"/>
        <property type="gene ID" value="HS99_0008225"/>
    </dbReference>
    <dbReference type="OMA" id="HTLDDSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="24660" checksum="9352DE58D1E4EC3F" modified="2017-01-18" version="1">MTTSSTTALALDHGDDRGLQAVLLDMDGTLVDTEDFWWQAEATLFAELGHQLDEQDRAHVVGGPMTRVMDYLVARTGVDIAPADLGVLVNQRFVDLLAGGVPLMPGAERLLNTLAAHGVPAALVSASHRHVIDIVLRSLGAEYFAFSIAGDEVPRTKPFPDPYLAAACRLGAEPGRCVVVEDTPTGVRAGEAAGCPVIAVPSVAPIEAAPGRLVVPSLEQVDLELLRSLVASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6V6</accession>
    <name>A0A1E7N6V6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386241.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene228"/>
    <dbReference type="EnsemblBacteria" id="OEV36437">
        <property type="protein sequence ID" value="OEV36437"/>
        <property type="gene ID" value="HS99_0029300"/>
    </dbReference>
    <dbReference type="OMA" id="WWHIFHS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20372" checksum="8661A946603580FA" modified="2017-01-18" version="1">MIIGMALTPYQQQLHDRVVAATEVVPPPAPWRPVRGGLIPVGGLTGIGFAVHPETGHDLVLTVSSTGHGLFDAVTGEKLERDYDPEEDPDGPDLSCPGIGPVADVRIPVAGLWGGGLHTDAAGGWGVEVISPEWPHHRVLLTSGPWTGEHGQAWHHVFHVCWSEFRAAGFSPTGRTLAVATSSDLTLWTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y9</accession>
    <name>A0A1E7N6Y9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554243.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene225"/>
    <dbReference type="EnsemblBacteria" id="ARF82256">
        <property type="protein sequence ID" value="ARF82256"/>
        <property type="gene ID" value="B6264_28300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36439">
        <property type="protein sequence ID" value="OEV36439"/>
        <property type="gene ID" value="HS99_0029315"/>
    </dbReference>
    <dbReference type="OMA" id="VMEVASY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="424" mass="45905" checksum="0B94703BCF1EC927" modified="2017-01-18" version="1">MADSERPIVIVGASLGGAKAAEALREAGYRGGIVLIGEEHERPYERPPLSKGYLTGKDDREKIYVHPPQWYAEHDITLRLGTAVAAIDPAAHTVTLADDGQVGYHKLLLTTGSEPRRLPVPGAEQDGVLYLRRVDDSDRIKAALRPGARIAVIGAGWIGLEVAAAARTVGAEVTVLEALELPLLRVLGREVAQVFADLHRDHGVDLRFGVQVTELTGADGKVSGVKLGDGSEVAADAVVVGIGISPATALAEAAGLEVDNGIRTDQHLRTSDPDVYAAGDVANAHHPLFDRHIRVEHWANALNQPQTAARAMLGQPDAVYDRVPYFFTDAEWTPRQPNEPVASRDKLSMEYLGYVEPDGYDRVVFRGDVKANEFIAFWLKDGRVLAGMNMNVWDVTDPIRELIVSKRVVDADRLANPNIALGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N747</accession>
    <name>A0A1E7N747_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555379.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000953.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1455"/>
    <dbReference type="EnsemblBacteria" id="ARF79176">
        <property type="protein sequence ID" value="ARF79176"/>
        <property type="gene ID" value="B6264_09805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36521">
        <property type="protein sequence ID" value="OEV36521"/>
        <property type="gene ID" value="HS99_0028775"/>
    </dbReference>
    <dbReference type="OMA" id="DDCGAPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="32699" checksum="3A232E16366947BF" modified="2017-01-18" version="1">MSQPATPPVLAEVIRSGFTEGRHHGSLVLLAADGSVEFVLGDPDAPVFPRSTAKPFQAVATLRAGLAIEGELLALAASSHSAESFHLDGVRAILGSAGLDESALRTPADLPLDETEAELLLAAGGRRAPILMDCSGKHAGWLAACVANGWDTGSYLDPAHPIQELAREALAEGTGETPVHTGVDGCGAPLLAVTLTGLARGYRSLVLAAEGTAQRRIADAMRAHPEYVAGTRRADTWLMRAVPGALSKMGAEAVQVVALPDGRALAFKIDDGAERARGPVLAAALRRLGVTGADDTVERIGAAPLLGGGAPVGEVRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R6</accession>
    <name>A0A1E7N7R6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550701.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000136.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2488"/>
    <dbReference type="EnsemblBacteria" id="ARF81512">
        <property type="protein sequence ID" value="ARF81512"/>
        <property type="gene ID" value="B6264_23670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36684">
        <property type="protein sequence ID" value="OEV36684"/>
        <property type="gene ID" value="HS99_0028385"/>
    </dbReference>
    <dbReference type="OMA" id="THLNRTM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="23942" checksum="F5757275F25385B8" modified="2017-01-18" version="1">MTSVLIVDDQVLIRAGIAALVRATDGLEVAGEAATGEEAVDLAAGCAPDVVLMDIRLPGMSGIAALERILAAAPPPKPRVAMLTVYDLDQYVYAALRAGASGFLLKDTPPERLLAAVRQIADGEMLFAPTVTRRLVETFARQAEPLVGRPDTLHGLTARERDVLHLVGRGLTNDQIAESLVVSTATVKTHVNRVMSKLALSSRAQAVVVAYESGLVTVGGDRRPTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7U8</accession>
    <name>A0A1E7N7U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387366.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000853.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4770"/>
    <dbReference type="EnsemblBacteria" id="OEV36748">
        <property type="protein sequence ID" value="OEV36748"/>
        <property type="gene ID" value="HS99_0027410"/>
    </dbReference>
    <dbReference type="OMA" id="IGNPRCS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="42425" checksum="33B719E19F00E7B3" modified="2017-01-18" version="1">MSDHRTDRTGPADALRPESRIVHLPLAEAAGSRPLGIPLHQSHLFAFETSEALTSAFGGPDGAFFYNRFGNPTVRSLESAVADLEGGAGAIATASGMGAINTVLLALLRSGDHVIAQRSLYGGTFAMLADLGQRWGVEVTHVSGDDPDEVAAALRPNTRLLHLETISNPTTRVTDLPGLIAVARGAGVLSVVDNTFATPLLCRPIEHGADVVVHSATKYLGGHSDVLAGIAVFAEAELHRKVWHYATELGASADPFAAWLTVRGLQTLALRVRRHCDTALDLATRLSAHPAVSAVHYPGLPAHPDHDLARRLLPDGHGGVLAFDLAGGREAARAFTESVRLASLAPSLGGVHTLVLHPASTSHRQLSDEELAAAGIGAGTVRVSVGIEHPEDLWTDVEQALAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7W9</accession>
    <name>A0A1E7N7W9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553010.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4823"/>
    <dbReference type="EnsemblBacteria" id="ARF82435">
        <property type="protein sequence ID" value="ARF82435"/>
        <property type="gene ID" value="B6264_29350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36785">
        <property type="protein sequence ID" value="OEV36785"/>
        <property type="gene ID" value="HS99_0027660"/>
    </dbReference>
    <dbReference type="OMA" id="MARTIRH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22806" checksum="BEF9FEE42CD415D4" modified="2017-01-18" version="1">MRVNPQDAAAPESGRTFVTDARRAQIVTAAIETVAELGYARASFAQIAKRAGLSSVRLISYHFDDKGDLFQALVDTVQEQARVAMQPRVRAQHEPAAMLAAYIEANLDFLAEHPVEVRALVDVLANARREDGSPLVSAAGFDTPVALLVQHLRDGQRSGAFRPFDAEAMAMAIRASIDAAANRLAVGDDFDPRAYGRELVTLFGLATANGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7X6</accession>
    <name>A0A1E7N7X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553027.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000698.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4840"/>
    <dbReference type="EnsemblBacteria" id="ARF82419">
        <property type="protein sequence ID" value="ARF82419"/>
        <property type="gene ID" value="B6264_29265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36800">
        <property type="protein sequence ID" value="OEV36800"/>
        <property type="gene ID" value="HS99_0027745"/>
    </dbReference>
    <dbReference type="OMA" id="KMSLYRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="241" mass="25512" checksum="DED809EB69F11731" modified="2017-01-18" version="1">MGEAANDTVRLLWDRPTRPTRGPKPALSLERIAAAGVEVADAEGLGAVSMQKVAGLLDFTKMSLYRYVPGKAELVALMVESAVGEPPAAPDAPDWREQLTAWARHLADAFARHPWLLDATLGPRVPGPNELAWLERVVAALDGHGLTGAERMDAAVLLSGHVRSIAVQARATGPHGSPEAQLLAAFGTVVHRHADRFPAVAAAMADPDPEGRDQALDFGLARILDGLAALIGRRTNRGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Y0</accession>
    <name>A0A1E7N7Y0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737866.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4857"/>
    <dbReference type="EnsemblBacteria" id="ARF82405">
        <property type="protein sequence ID" value="ARF82405"/>
        <property type="gene ID" value="B6264_29180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36812">
        <property type="protein sequence ID" value="OEV36812"/>
        <property type="gene ID" value="HS99_0027830"/>
    </dbReference>
    <dbReference type="OMA" id="ITAVCAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="187"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="50579" checksum="6E3743DBDBA1DA03" modified="2017-01-18" version="1">MSDTWQRLRREHPRLLDAAGGLALLAVTGLGATVDQVTGHFAPVDPATGVLALIAAAAVFFHRRHPRAVAAVTLVCTMMLTWTSPRLTPMLATPLLLALYFLAVRTDRSTALRASIATAVLLTGISLLFGPTGPIGERISVLAWALLPGALGDSIRNRRAHLAAIEERAERAERTREEEARRRVADERIRIARDLHDVVAHHIALANAQAGIALHLMDSHPVQAREVLSHITDATGSALHELRATVGLLRRAEDPAPLEPAPGLDRLPELINTFERAGVPVRLTVEGESRPLSPGVDLTAFRIVQESLTNVAKHAHGADAEVTLSYSGSRVAVTVANGRPTATGRPRTALLPPPAPGESGFGLIGMRERAGAVGGRLTADHRPGGGFLVTAELPLRTGARDDAGPWTDGAARPAAATTEPGGPAEPAARERPAHAFWRDCTVRPARPDRSADSASAAGSPDTIRQDRVIRKDKDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Z3</accession>
    <name>A0A1E7N7Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552954.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000282.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4761"/>
    <dbReference type="EnsemblBacteria" id="OEV36826">
        <property type="protein sequence ID" value="OEV36826"/>
        <property type="gene ID" value="HS99_0027365"/>
    </dbReference>
    <dbReference type="OMA" id="RPDSGAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="18"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="26529" checksum="DE9F7F43475365FA" modified="2017-01-18" version="1">MTTAAAGAAHGGATGAALTGEGLHREYGRGAAAVRALRGVSVAFAPGTFTAVMGPSGSGKTTLLHCLAGMDRPSRGTVRWGDTEVSGLPERRLADLRRTRVGFVFQAFNLMPAMTVAQNVELPGRLAGHPPERARVREALARVGLAGRERHRPGQLSGGQQQRVAIARALVARPEVLFADEPTGALDRATGHDILDLLRAGVDEDGQTCVMVTHDPVAAGYADRVLLLADGVLVDELVRPTAAQVGERLSRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N870</accession>
    <name>A0A1E7N870_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Biotin synthase</fullName>
            <ecNumber evidence="2 9">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bioB</name>
        <name evidence="10" type="ORF">HS99_0028265</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="2 9"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550730.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000737.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2514"/>
    <dbReference type="EnsemblBacteria" id="ARF81490">
        <property type="protein sequence ID" value="ARF81490"/>
        <property type="gene ID" value="B6264_23550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36663">
        <property type="protein sequence ID" value="OEV36663"/>
        <property type="gene ID" value="HS99_0028265"/>
    </dbReference>
    <dbReference type="OMA" id="ADRFCMG"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="42556" checksum="2689729C67BDF5C5" modified="2017-01-18" version="1">MDLLDTLTAKGLRGEVPTREEALAVLATTDDELLDVVAAAGRVRRRWFGRRVKLNYLVNLKSGLCPEDCSYCSQRLGSKAEILKYTWLKPEQAADAARAGVAGGAKRVCLVASGRGPTDRDIDRVTDTMAAIKDADPEVEICVCLGLLSDNQAERLKAAGADAYNHNLNTSENTYGTITKTHTYADRVDTVQKAHGAGLSACSGLIAGMGETDEDLVDVVFALRELGSDSVPVNFLIPFEGTPLAKEWNLTPQRCLRILAMVRFVNPDTEVRIAGGREVHLRSMQPLGLHIANSIFLGDYLTSEGQAGQADLDMIKDAGFEVEGAGEATLPRHRADVAEAAAAAGSCGSAASACGSGGGCGPCGGHSHGAPEAAPVTEGTDDGLREDLVKVRRRGAGTELAPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E3</accession>
    <name>A0A1E7N8E3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="8" type="ORF">HS99_0027065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287040.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6837"/>
    <dbReference type="EnsemblBacteria" id="ARF78630">
        <property type="protein sequence ID" value="ARF78630"/>
        <property type="gene ID" value="B6264_06625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36924">
        <property type="protein sequence ID" value="OEV36924"/>
        <property type="gene ID" value="HS99_0027065"/>
    </dbReference>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="373" mass="39638" checksum="4453AE54CE93C5BB" modified="2017-01-18" version="1">MSSLRLTALDALHRALGATMTDFAGWDMPLRYGSEREEHLAVRTKAGLFDLSHMGEITVTGPQAGEMLDHALVGFVSALGVLRARYTMICAEDGGILDDLIVYRLREDAFLVVANASNAQLVLDELIARAKGFDAVVTDDRDTYALIAVQGPEATAILAKTTDADLPGLKYYAILPAKVAGREVLLARTGYTGEDGFEIFCHPVDAEPVWQALTAAGEGHGLVPCGLSCRDTLRLEAGMPLYGHELSTDLTPFDAGLGRVVRFDKTTNDGAFVGRKALEQAAAAAESNPPKVLVGLVSEGKRVPRAEYTVVSTDGAPIGRITSGAPSPTLGKPIAMAYVDAAHAEPGTTVAVDVRGKHEPVQVVALPFYKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T8</accession>
    <name>A0A1E7N8T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556087.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81649">
        <property type="protein sequence ID" value="ARF81649"/>
        <property type="gene ID" value="B6264_24535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37078">
        <property type="protein sequence ID" value="OEV37078"/>
        <property type="gene ID" value="HS99_0004455"/>
    </dbReference>
    <dbReference type="OMA" id="DDHAHIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="228" mass="24734" checksum="8CA6CDD329D04F49" modified="2017-01-18" version="1">MKAFHPTFGRQPWPDGVRVLQVYALPDLSAGSALRTLLGDLRKSLAGFPVVPVPDDHAHITLDMITSTPPDAIGEAERRELADRLRTAVAGTGPLVLQAGSPLAYRTGVRLDLHPDHQLAVLQHRVRSAIHQVCGPDSTAYPLGVLHMTAGYAAADVDTDELAQVIHRVRPGHAPFTVRRIELIEVYWQRVPVDGSDASGRRIRWDTVAAVPLDDVPTAGLHATSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8X9</accession>
    <name>A0A1E7N8X9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81592">
        <property type="protein sequence ID" value="ARF81592"/>
        <property type="gene ID" value="B6264_24195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37141">
        <property type="protein sequence ID" value="OEV37141"/>
        <property type="gene ID" value="HS99_0004800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="15691" checksum="8DE6BE4D01CF87C2" modified="2017-01-18" version="1">MAGGRPVAAVLAAVLSAGLLAGCSSGAEEARLEHSADYSAHLHLKVTGYPVPETLGLVQQVVWRLADGSADRLVKLAAAEGTADARRAAAEVWIRDYGPAAAGEVTADFGDDPANRQTVRITFHATGRVKELTLRLDGRDGSGGWRVMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Z3</accession>
    <name>A0A1E7N8Z3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287022.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6828"/>
    <dbReference type="EnsemblBacteria" id="ARF78621">
        <property type="protein sequence ID" value="ARF78621"/>
        <property type="gene ID" value="B6264_06580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36933">
        <property type="protein sequence ID" value="OEV36933"/>
        <property type="gene ID" value="HS99_0027110"/>
    </dbReference>
    <dbReference type="OMA" id="PRWCENR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="258" mass="27203" checksum="719C6182DB5130D3" modified="2017-01-18" version="1">MSQSVDRALTLLGSLGDGPLSLDQAASSLGVHKSTALRLLRTLEEHGFVRRQPDLRYRVGGRVLSLAHRALEDFDVRQVAAPYLAALNARCGYTVQLAVLHDGEVLYLDEVGPPPTALPPRIGRRAPVTGTAVGRVLLAGLPEDGTREEELPAELAAVRRRGWAAESAEHREPVTCVAAPVAGSGGRTVAACALSAPASQVAPAELARMLPELLCTAEAISLAYGGSPTPRWCENRCGARPAGRASRTSGRASAARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N938</accession>
    <name>A0A1E7N938_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6200"/>
    <dbReference type="EnsemblBacteria" id="OEV37178">
        <property type="protein sequence ID" value="OEV37178"/>
        <property type="gene ID" value="HS99_0005020"/>
    </dbReference>
    <dbReference type="OMA" id="LWIQANR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198891" evidence="2">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="42421" checksum="3FF08AB713D7734D" modified="2017-01-18" version="1">MVLIVIASLLSLLSVLAVWTSDFVGDTDRYVRTVAPLASQPDVQTAVTNRVTQVVLEQIDVNALVKELSDAAAQQGVPQNAANLINDLSGPIKSGLTQLVGSVVNKVVTSSAFETVWVEANRAVHSSLDKALTGQGGGAIKLENNQVAIDLAPVIAKVKDELVNAGLGVAAKIPDVHTNFVVFASDDIGKVKSYLRLLDIMGAWLPVVTVLIAAGGVFLAVNRRRALVGAAVGVALAMLLLGIALTVFRAFYLDHLPPGADQAAAGTVYDTLIRFMRATVRAVGTVAVVTAVGAALIGPSRPAVAVRTGCRRIIGSLRGALYSLGMRLGPVGPFVHRFKRWIGALILLVAAVILATWSYPTWAVVLWITFFVALAFAIREFLDTGGDGDRAPTPTTTGGPPPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N993</accession>
    <name>A0A1E7N993_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555238.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000622.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37238">
        <property type="protein sequence ID" value="OEV37238"/>
        <property type="gene ID" value="HS99_0005395"/>
    </dbReference>
    <dbReference type="OMA" id="WDETRID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030598">
        <property type="term" value="F:rRNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036041">
        <property type="entry name" value="Ribosome-inact_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017989">
        <property type="entry name" value="Ribosome_inactivat_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001574">
        <property type="entry name" value="Ribosome_inactivat_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016138">
        <property type="entry name" value="Ribosome_inactivat_prot_sub1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00161">
        <property type="entry name" value="RIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00396">
        <property type="entry name" value="SHIGARICIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56371">
        <property type="entry name" value="SSF56371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198897" evidence="1">
        <location>
            <begin position="28"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="33564" checksum="DEE32326B0FFE3A6" modified="2017-01-18" version="1">MKKNHVALLSLSAATALLVSLAGTASAAPTLTGKPAGGDRIRSAPATRAAALQSWPIIDWDITDITAGRGEHANRYWNLIDAIHRNTYGDATNVGSGLVQQTTRNENRLIQIRVMNQGAHLVSVYMWADNLYIAGFYSPAANRHWAFQDGRQQQFQNDLGVQAQFMPRTGNYNGITGGSARENLYLGSTNIFNALRDLNNVPQWDETRIDRGMLMAITIFSEAARFGPIFNRIYGNINAWTTNQLSVDYRDMENQWGRLSQAAHAWRQGRAASVRLIGNNVSSFDDLRRVVGFVELHGSEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N995</accession>
    <name>A0A1E7N995_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0005595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555165.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1296"/>
    <dbReference type="EnsemblBacteria" id="OEV37270">
        <property type="protein sequence ID" value="OEV37270"/>
        <property type="gene ID" value="HS99_0005595"/>
    </dbReference>
    <dbReference type="OMA" id="THFMNPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="4">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="29981" checksum="266377B1FDC83A73" modified="2017-01-18" version="1">MDEQLIAIVGAGVMGTGISTLVVGAGLPVVLVDVDQGVLERATTAIANGLRHAQLTGALPPGRTPGELRTTLSLSDVAAADVVIEAVTELPDQKAQVLSAVSALVRPATPLISNTSGIPIDEMAAWVKNPDDLIGTHFMNPAYLISMVEVIRGPQTADRTVESVLSLLTRIGRRAVVVHDAPGFVTSRLLHPMINDAAQVVRAGTATVEDVDTLMQGCLGHPTGPLRTADLIGIDNLVDALEALYARTGDERCRPSELLLEKVRRGELGRKSGRGFYNYSEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F5</accession>
    <name>A0A1E7N9F5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5473"/>
    <dbReference type="EnsemblBacteria" id="OEV37325">
        <property type="protein sequence ID" value="OEV37325"/>
        <property type="gene ID" value="HS99_0005930"/>
    </dbReference>
    <dbReference type="OMA" id="FTTYQGD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33290" checksum="E1EEDE78599C910A" modified="2017-01-18" version="1">MKVHPVTALFPMLGPDELLDLAQDIESNGLTEPVILDADGVLLDGRGRLAACELADVEPRFTTYQGDDPVCLIVSANRHHPNTTASQHAMIAAMARSLSPGSLPSDTARCGINVTRLSIATTVLEHAPDLAEQVRIGTLALNAAYTAVRRRKADAKALLAQHARLRQHAPDLAEQVIAGHLAVTDATAALDSRQEEEHLRRRVEEIDAIRLADGDTTPAFARTAEAGDVDWRHAHQMAEQYLAQRHDAIRHVQHSLAGIAELWSAVQDLAHHSRSPYAREILKGLTGPARTLAHRLIALETACATGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R3</accession>
    <name>A0A1E7N9R3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556611.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000238.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6195"/>
    <dbReference type="EnsemblBacteria" id="OEV37431">
        <property type="protein sequence ID" value="OEV37431"/>
        <property type="gene ID" value="HS99_0005045"/>
    </dbReference>
    <dbReference type="OMA" id="DVWIADN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198914" evidence="2">
        <location>
            <begin position="24"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="641" mass="65544" checksum="F01E56CA8E45FA51" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9X1</accession>
    <name>A0A1E7N9X1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287133.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7961"/>
    <dbReference type="EnsemblBacteria" id="ARF79082">
        <property type="protein sequence ID" value="ARF79082"/>
        <property type="gene ID" value="B6264_09265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37491">
        <property type="protein sequence ID" value="OEV37491"/>
        <property type="gene ID" value="HS99_0026090"/>
    </dbReference>
    <dbReference type="OMA" id="WSMLGAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="175" mass="19720" checksum="83BC2C7096A2A630" modified="2017-01-18" version="1">MPDAYTVLWTQDTCRELRKEGRVGQRPPVAFSGAHQSLPAWSGARVGDEVYALHVKQREVFVVSRMRIVDRERGDCCGAEPETWRDPGFPGHADWWMLGAGGCGADAVHVDATPVRFDQRIPGDLLPRLTWRNRRNQTRGLKYVVDGRLERFVSLQGFYRLTPESADELAELVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA44</accession>
    <name>A0A1E7NA44_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0026500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366617.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1131"/>
    <dbReference type="EnsemblBacteria" id="OEV37560">
        <property type="protein sequence ID" value="OEV37560"/>
        <property type="gene ID" value="HS99_0026500"/>
    </dbReference>
    <dbReference type="OMA" id="SRQQGWW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="32596" checksum="57866692F7F7CF32" modified="2017-01-18" version="1">MSANINPTVRRRRLGSELRKLREGLGMTAEEVAGRLMVSQSKISRLENGRRSISQRDVRDLCDVYNVSDEQMRSSLMEMAKESRQRGWWHDFNNMPTPYSVYIGLEAEASSIRAYESSFIPGLLQTEQYAQAVVEGTQPDTDANAVQRRVQVRMKRQERVHGDNQLGSLWTVIDEAALRREVGSREVMARQLRQMLELSLRPNITIQVIPFSHGAHPGMTGTFSLLEFPESADSTVVYFEGVTSDLYLEKEADVRRYTGLYDYLRAAALGVAESRSLIADIEKGYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAG8</accession>
    <name>A0A1E7NAG8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="7" type="ORF">HS99_0025685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030259703.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1657"/>
    <dbReference type="EnsemblBacteria" id="ARF79952">
        <property type="protein sequence ID" value="ARF79952"/>
        <property type="gene ID" value="B6264_14475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37695">
        <property type="protein sequence ID" value="OEV37695"/>
        <property type="gene ID" value="HS99_0025685"/>
    </dbReference>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="126" mass="14306" checksum="A798A000C8D73BD4" modified="2017-01-18" version="1">MARLAGVDLPREKRIEIALTYVYGIGRTRAQQTLAETGVNPDVRVRDITEEDLVKLSQYIDANYTVEGDLRREVAADIRRKVEIGCYEGLRHRRGLPVRGQRTHTNARTRKGPRRAIAGKKKPGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAQ9</accession>
    <name>A0A1E7NAQ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0025850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553118.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4910"/>
    <dbReference type="EnsemblBacteria" id="ARF79982">
        <property type="protein sequence ID" value="ARF79982"/>
        <property type="gene ID" value="B6264_14640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37724">
        <property type="protein sequence ID" value="OEV37724"/>
        <property type="gene ID" value="HS99_0025850"/>
    </dbReference>
    <dbReference type="OMA" id="LYAMVEG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="646" mass="67273" checksum="B06D5AED67C113B5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAS2</accession>
    <name>A0A1E7NAS2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557081.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000201.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3757"/>
    <dbReference type="EnsemblBacteria" id="ARF78066">
        <property type="protein sequence ID" value="ARF78066"/>
        <property type="gene ID" value="B6264_03260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37800">
        <property type="protein sequence ID" value="OEV37800"/>
        <property type="gene ID" value="HS99_0024735"/>
    </dbReference>
    <dbReference type="OMA" id="HQLASWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1857" mass="203843" checksum="47995D24C1DF0FFB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF9</accession>
    <name>A0A1E7NBF9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78063">
        <property type="protein sequence ID" value="ARF78063"/>
        <property type="gene ID" value="B6264_03245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37803">
        <property type="protein sequence ID" value="OEV37803"/>
        <property type="gene ID" value="HS99_0024750"/>
    </dbReference>
    <dbReference type="OMA" id="HWAYRAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="28557" checksum="D150775CF5CAA065" modified="2017-01-18" version="1">MRVRFVAEEAEGREEWVPPASLRVPWDQKDVWLSRQNRWDALTSDGPLNDEVVEFVAASIVFEECPMDETVSMGWNYRERGVLYVHDATALAAMLQVSEDMFASDPRSFTDGAGTLTAPWPTTLAVTPLIAKAHAEQLVAVLAQREEQSQREAVYGQYLGGRGKSGGTYISAETCAEVDRKYKPARDLVRNWCGTEAVDSFAELKALRTEVVRVGKLMEEAIRSLRDAGQVRAADHFERQLGVPLELLRNASAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBL9</accession>
    <name>A0A1E7NBL9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835589.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3005"/>
    <dbReference type="EnsemblBacteria" id="ARF79701">
        <property type="protein sequence ID" value="ARF79701"/>
        <property type="gene ID" value="B6264_13005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38089">
        <property type="protein sequence ID" value="OEV38089"/>
        <property type="gene ID" value="HS99_0023095"/>
    </dbReference>
    <dbReference type="OMA" id="ALCHTYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="32159" checksum="ADA454C19DBF6B1E" modified="2017-01-18" version="1">MSTNRSRRIDRDAAEQLLGGAVGGPSAGQDASLTGPDGPGQLARVLAAAAAPATAAELAGEEAALAAFREASLTPDPLVTPVRRRSMATAALARAFSTKAAAAVLGATALCGVAVAAGTGNLPALGGPTEPEHSVAASGSPTDSTHGTTGTTASPGTTGSPGSASPSGSARPTTGAQADPPHGVAPSAPATPGARGDHPSPPAALVPLCQNFADRTNKGERPRQLAADPLFAPLIAAAGGADGVPDFCDGTPGHSNGDHQGTPAQPSPSTRNGTPNGNGNANGNTNGEDTSGGNGAKPGKGGVTGTLPPALPTPPNARPSRTGPSEDEQSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBR0</accession>
    <name>A0A1E7NBR0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nhaA</name>
        <name evidence="9" type="ORF">HS99_0023335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385981.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7155"/>
    <dbReference type="EnsemblBacteria" id="ARF79661">
        <property type="protein sequence ID" value="ARF79661"/>
        <property type="gene ID" value="B6264_12760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38130">
        <property type="protein sequence ID" value="OEV38130"/>
        <property type="gene ID" value="HS99_0023335"/>
    </dbReference>
    <dbReference type="OMA" id="MGLMLRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00773">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="48789" checksum="C41BAB0ECD4FDAD9" modified="2017-01-18" version="1">MTDQPPVHEPTTRRQQFLGRLSLPERTFITDALRTETVGGMLLLTAAVVALIWANVWPHSYESVLDYRIGPSAPLHLDLTLATWAKDGLLTIFFFVAGIELKREFVAGELRTPSAALLPVVAAVCGVAMPAVLFALVNSGSGGHPGGWAIPTATDIAFALGVLAVVGSHLPSALRAFLLTLAVVDDLIAILIIAIFYSSGIKFWALGLAFAGLVLFWFLHRRGVKGWYLFVPLAVVVWALMHESGVHATVAGVAMGLMLRCHREGDEKHSPGEHIEHLVRPLSAGLAVPVFALFSAGVTISVPALREVFTQATPLGIVTGLLVGKTVGIFGGTWLAARFTRAELNPRLKWADLFAVSVLAGIGFTVSLLISELAFPHDLALADRSKTAVLVGSLLCATIATVLLKLRTRHYRTLCEEEDQDADGGVGGSVDGDGVPDVRQQDEPARRLPREGFGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT8</accession>
    <name>A0A1E7NBT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288132.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7127"/>
    <dbReference type="EnsemblBacteria" id="ARF79639">
        <property type="protein sequence ID" value="ARF79639"/>
        <property type="gene ID" value="B6264_12635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38152">
        <property type="protein sequence ID" value="OEV38152"/>
        <property type="gene ID" value="HS99_0023455"/>
    </dbReference>
    <dbReference type="OMA" id="PVRFACP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="33889" checksum="B1C84732B87203B9" modified="2017-01-18" version="1">MRPLYSVPLGVAAAGAACLAYSVGYEVRAFRLRRIEVPVLPHGAKPVRILQVSDIHMVTGQGKKQRWLKSLAGLRPDLVVNTGDNLSDPLGVPATLDALGPLMDFPGVYVFGSNDYYGPARKNPARYLQAMRSGVHGMNNPDGTGNRGISGAVHNPWEKLRDGFDAAGWLDLTNTRGRLTVNGLDMEFTGLDDPHIRRDRYAEVSGGPSADADLSLAVVHAPYLRVLDAFTADRYPLILAGHTHGGQLCIPFYGALVTNCDLDTRRVKGLSTHQAGGHRSYLHVSAGCGTNRYTPVRFACPPEATLLTLTPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC28</accession>
    <name>A0A1E7NC28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290725.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1746"/>
    <dbReference type="EnsemblBacteria" id="ARF80235">
        <property type="protein sequence ID" value="ARF80235"/>
        <property type="gene ID" value="B6264_16125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38249">
        <property type="protein sequence ID" value="OEV38249"/>
        <property type="gene ID" value="HS99_0022155"/>
    </dbReference>
    <dbReference type="OMA" id="WAWTGGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="20494" checksum="5AA4595C575229B0" modified="2017-01-18" version="1">MVTTGTAPQSPDLARLLAGHRPQGPVETADHARARALVDAPDAWDRGTPLHFTASALIVHPPTRRVLLRWHVRQQAWLQVGGHGDPGETLPLDIALREGLEETGLTDLTPWPDAALVHLAVVPVPASPVEPAHEHADLRFLLATGTPDDARPENPASPLEWLTVEEARERTTEENLRETLDRAARLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC43</accession>
    <name>A0A1E7NC43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1731"/>
    <dbReference type="EnsemblBacteria" id="ARF80220">
        <property type="protein sequence ID" value="ARF80220"/>
        <property type="gene ID" value="B6264_16035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38262">
        <property type="protein sequence ID" value="OEV38262"/>
        <property type="gene ID" value="HS99_0022235"/>
    </dbReference>
    <dbReference type="OMA" id="EVERWFN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18194" checksum="C59885844BDAE716" modified="2017-01-18" version="1">MVEHWLNRPRLLIGAAVVLVVLSLVVELEFRTRFSQIGCAVLLVPLVVAAVPVLSVSLVFSGHGGREDRFVSPNRSNRVLSVTNVAFSIDPVYQVELETGSGWSARHWSLGTWNTRGGDFVRIDWSGPDQITVTGRHKLTVFDVHPDGSLSEPRVLPKQSDPGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC59</accession>
    <name>A0A1E7NC59_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0022080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000718.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3339"/>
    <dbReference type="EnsemblBacteria" id="ARF80246">
        <property type="protein sequence ID" value="ARF80246"/>
        <property type="gene ID" value="B6264_16200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38238">
        <property type="protein sequence ID" value="OEV38238"/>
        <property type="gene ID" value="HS99_0022080"/>
    </dbReference>
    <dbReference type="OMA" id="AYAKQTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="43117" checksum="C065F782DB746612" modified="2017-01-18" version="1">MRSTTALTRTASGARPGAALPDGPARKLAAVAACALLAAGCAEAGTAGTAGTASGGGGGAKTPVKVGLVYSRTGPLAAYGKQYLDGFKAGLSYATKGTGEVDGHRIEFEEQDDAGDPAKAVSAAKDLIGKGYKVLAGSTASGVALQVGPIASQNKVLFISGPAAADKVTGLNKYTFRSGRQSYQDIRTAASFIGDAKGKKVAVLAQDNAFGQANVAAVKAVLGSQGATVEQVLAPPSATDLTPFATQAKTAKPDLLFVAWAGDSASALWTALNQQDVFADTKVVTGLDLAASYPLFGPAGDKISFLNHYFDGAAGTPVEKAMTEAVTAGGGRPDIFTPDGFTAAQMIVHAVESNHGSAEDTSALVKALEGWSFDGVKGRTTVRAEDHALLQPMFQVRLTGAGAAAKPSVEKTLTADEVAPPVTPMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC83</accession>
    <name>A0A1E7NC83_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_S8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4177"/>
    <dbReference type="EnsemblBacteria" id="OEV38300">
        <property type="protein sequence ID" value="OEV38300"/>
        <property type="gene ID" value="HS99_0022460"/>
    </dbReference>
    <dbReference type="OMA" id="WAKDEPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="159" mass="15758" checksum="0446555323D2DD8F" modified="2017-01-18" version="1">MSGTSDATAYVSATAALIRSKYPNLSAGQVINRMIKSATPPANGTVVPNNHYGYGTVSPAKALDPNPAVDNGPKDNPLAKRPESKGTPHIDEDSDATDQPSVAPEAASGSGGGSDDTGQVIAAVAAGAVVLGASVAAVVTARRRKRAAAAVPPYGGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCC6</accession>
    <name>A0A1E7NCC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290049.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000494.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3317"/>
    <dbReference type="EnsemblBacteria" id="ARF82867">
        <property type="protein sequence ID" value="ARF82867"/>
        <property type="gene ID" value="B6264_16320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38342">
        <property type="protein sequence ID" value="OEV38342"/>
        <property type="gene ID" value="HS99_0021960"/>
    </dbReference>
    <dbReference type="OMA" id="HEVEGCP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="337" mass="36807" checksum="336BF4652AC474A5" modified="2017-01-18" version="1">MRCADVYAPVVELDVRHLRVLCAIADTGSLRKAALQLGMTQPSLTTQLHRIERAIGGTLFTREQTGSRPTALGHSVLSRARPVITEMAALVAAARQEARDTTGPGRQRRLRIGSVGSRAVAAWLRRVHERLPDTDTTIHVDVSASALLRMVAADQLDVAFVYECEGFPLRVPPDAEHRVLMAREPQFVALAAGHPAAARPVVHLSDLAEDTWMVDPTADHEYAAMRRVFSEAGLNPRVVQVRDNATAAELVASGEAVRPCQPTSLPGPGTVVRPVHGDPLAVRLLFTWRPRVLSQPALDALYGELRAAYLDLAKVNPAYLAWLARHEPVLLERVQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCD9</accession>
    <name>A0A1E7NCD9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386343.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000326.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1726"/>
    <dbReference type="EnsemblBacteria" id="OEV38352">
        <property type="protein sequence ID" value="OEV38352"/>
        <property type="gene ID" value="HS99_0022260"/>
    </dbReference>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="35937" checksum="7B4737FF199A1862" modified="2017-01-18" version="1">MPKAELHVHHVGSASPRIVADLAARHAGNSKVPTDPAALAEYFTFTDFAHFIEVYLSVVDLVRDAEDVRALTYGVAEDMARQNIRYAELTLTPYSSVRRGIPDVAYMEAIEDARLRAEKDLGVVLRWCFDIPGEAGLEAAEVTARLATELAPEGLVSFGLGGPEIGVPRPQFKPYFDRARASGLRSVPHAGETTGPQTVWDAIRELGAERIGHGTQAVKDPALLDHLGEHRIPLEVCPTSNIATRAVERIEDHPIKRMVDAGLLVTVNSDDPPMFGTDLNTEYAVAARLLGLDETGVAALARNAVEASFLEQAGKARLVGEIDSYLAGWQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCM8</accession>
    <name>A0A1E7NCM8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366403.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000083.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene307"/>
    <dbReference type="EnsemblBacteria" id="ARF82171">
        <property type="protein sequence ID" value="ARF82171"/>
        <property type="gene ID" value="B6264_27795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38437">
        <property type="protein sequence ID" value="OEV38437"/>
        <property type="gene ID" value="HS99_0021260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21775" checksum="6541D626BF8BB993" modified="2017-01-18" version="1">MTFGQDMWTWGYKVADHETGHTFGLPDLYAFNGDLDQYVGGWDLMGRISGPAPSYFGWEAWKFGWITDSQVSCLDTANTYATTLTGLEYGGNGHRLAVIRTGATTAYVAESRKVAYNDSNACATGVLIYEVDTSTTTGNGPIQVVTNPNAAAPTGNCTALDMQTWQPGQWFQDDTARIRIHVNASDASTDTVWTYKVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCR6</accession>
    <name>A0A1E7NCR6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366410.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene358"/>
    <dbReference type="EnsemblBacteria" id="ARF82129">
        <property type="protein sequence ID" value="ARF82129"/>
        <property type="gene ID" value="B6264_27545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38475">
        <property type="protein sequence ID" value="OEV38475"/>
        <property type="gene ID" value="HS99_0021500"/>
    </dbReference>
    <dbReference type="OMA" id="PTQCFAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="296" mass="31609" checksum="B1D7A9FEA9198889" modified="2017-01-18" version="1">MSARTAPSHPARLAPFLAAYDALLARWPVPVEPLTVRTAHGTTRINACGPADGHPLVLLHGGGATSAMWYANAGALAEAGHRVLAVDLIGDPGRSVHDGTPLGDVPGLLGWLDAVLDQLGIPAAHFCGHSYGGWIALEYTLHTPTRVSSLTLLDPTQCFAGYRPGYLLRALPLFLPGRTPPRARNFLDWEAAPGSHTDTDWRELYALGYADFPASPVITGPRPTPTRLRTLTAPLLALYAEHSRAHDPHRTAAATRHTLPHATVTTIPGASHHTLPMAAAPEVNHHLLNFLPPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND06</accession>
    <name>A0A1E7ND06_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551532.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene698"/>
    <dbReference type="EnsemblBacteria" id="ARF77571">
        <property type="protein sequence ID" value="ARF77571"/>
        <property type="gene ID" value="B6264_00310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38548">
        <property type="protein sequence ID" value="OEV38548"/>
        <property type="gene ID" value="HS99_0019895"/>
    </dbReference>
    <dbReference type="OMA" id="YCLLRMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033458">
        <property type="entry name" value="DUF5134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17197">
        <property type="entry name" value="DUF5134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="188" mass="19103" checksum="75B967208656C714" modified="2017-01-18" version="1">MHGPTLVNWLLALLTATAGAYCLTRLRHAPCATAAPGTGPTNPPLARESDAAEALMGLGMAAMAVTGATVPAAVWACLFGLPAAAFLLAALHAPAGRAHRLHHAVGALAMTYMALAMTASPGGHHHATALGTPLLTGTLLLYFGGYSLWAGARLLRTPAGTLVLGTTGLPRACRLTMGIGMFAMLLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND58</accession>
    <name>A0A1E7ND58_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0020465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene585"/>
    <dbReference type="EnsemblBacteria" id="OEV38632">
        <property type="protein sequence ID" value="OEV38632"/>
        <property type="gene ID" value="HS99_0020465"/>
    </dbReference>
    <dbReference type="OMA" id="MESGRIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="180"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="547" mass="58911" checksum="5C3B6017CF4C69B8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE56</accession>
    <name>A0A1E7NE56_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="9" type="ORF">HS99_0018995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286371.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000458.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7350"/>
    <dbReference type="EnsemblBacteria" id="ARF82991">
        <property type="protein sequence ID" value="ARF82991"/>
        <property type="gene ID" value="B6264_21725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38918">
        <property type="protein sequence ID" value="OEV38918"/>
        <property type="gene ID" value="HS99_0018995"/>
    </dbReference>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="420" mass="45607" checksum="AEE71B2336E8D505" modified="2017-01-18" version="1">MSTFTAPKGTYDLLPPSSATFLAIRERIAAPARRAGYGYVETPVFEDVKLFSRGVGESTDIVSKEMYTLTTKGGDELALRPEGTASVLRAALQANLHKQGNLPVKLWYSGSYYRYERAQKGRYRQFSQVGAEAIGAEDPALDAELIILADDAFRSLGLSNYSLLLNSLGDKQCRPVYRAALIEFLAGLDLDEDTRRRAEINPLRVLDDKRESVQEQLVGAPMLRDFLCEECKAYDEKVRELLTANGVAFVDDPKLVRGLDYYTRTTFEFVHNGLGAQSAIGGGGRYDGLSEMIGGPALPSVGWALGVDRTYLALEAEGVDLDLPAATAVYAVALGEEAKNVLFAKVVELRRAGVATDLAFGVKSIKNAMKSADRSGARFALIAGDRDLAEGVVQLKDMSTGEQTPVALDALVTTLKEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEB6</accession>
    <name>A0A1E7NEB6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557522.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83269">
        <property type="protein sequence ID" value="ARF83269"/>
        <property type="gene ID" value="B6264_30490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39037">
        <property type="protein sequence ID" value="OEV39037"/>
        <property type="gene ID" value="HS99_0018220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13161" checksum="550C539873448F34" modified="2017-01-18" version="1">MGEPDGLLLLPCGVMWDVVRMPERLGLAALQALISDPTQETGPVLHDRSAGLVYVFIDLDSGISWSERYSDVRLLTTGAHLATPSPDTPWLNAQVVWAFLPPTPQPTNPTRLAAALDTLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NED5</accession>
    <name>A0A1E7NED5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83265">
        <property type="protein sequence ID" value="ARF83265"/>
        <property type="gene ID" value="B6264_30470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39034">
        <property type="protein sequence ID" value="OEV39034"/>
        <property type="gene ID" value="HS99_0018200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046270">
        <property type="entry name" value="DUF6303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19820">
        <property type="entry name" value="DUF6303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="7053" checksum="489BA3F893617A96" modified="2017-01-18" version="1">MGATPTGGWHLFITKDGSTTKHEHFFDGPPLPSRAQRVAALAHLGYRLADASYWTSATRPADAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEG5</accession>
    <name>A0A1E7NEG5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557168.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000211.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000061_gene4098"/>
    <dbReference type="EnsemblBacteria" id="ARF83335">
        <property type="protein sequence ID" value="ARF83335"/>
        <property type="gene ID" value="B6264_30930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39106">
        <property type="protein sequence ID" value="OEV39106"/>
        <property type="gene ID" value="HS99_0018655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="107" mass="12397" checksum="4AE4CFE9C7A3D729" modified="2017-01-18" version="1">MTAAVPFSRPRHPEHQPGDAERAPRELMSGPGRCWTVEPRWRWVDIRISGRWRPGRIELWRLHQGSTRWVALVRWGADPDDWGWYLYSPATVRQVSEPAPGCGPASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF56</accession>
    <name>A0A1E7NF56_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0000670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285004.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3599"/>
    <dbReference type="EnsemblBacteria" id="ARF82463">
        <property type="protein sequence ID" value="ARF82463"/>
        <property type="gene ID" value="B6264_29535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39265">
        <property type="protein sequence ID" value="OEV39265"/>
        <property type="gene ID" value="HS99_0000670"/>
    </dbReference>
    <dbReference type="OMA" id="AWPMSRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="47442" checksum="697F80BCBC92C812" modified="2017-01-18" version="1">MRRRLLAVLTALIGAAVLLLALPLADSYARGRTEHLLLQRRADGVRFAELADRIRTDADRRELDAELSRYAELYGAAVTVVDTAGRTVGLAGPAPSGTAAQRARDRALTGRSTEELPTVRPWGPDTVVLAEPVGQDERVGGAVLLTVPTGAARHDVLVRWALIAAGAVTSFGAAALVAAGIARWLLRPVHELDRAVATVAGGRFELRVASDTGPPELRRLRRNFDGMAQAVAESLRRRRDFVADASHQLRNPLATLVLQLENAEPHIGPGPGRQAHALALDEADRLGELLDGLLALARLEAATAPIEEQDVSAAVAGRVAAWEPVFEAGGLELTADVAPGLRALGLPDATGRILDALLDNASKFVPEGERVRVAATAAPEGGAVVRVTDTGPGVPASRLPLLVGRFARAPEHQNVPGTGLGLAIADELARACGGSLTVGATSPHGLTVEFRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFM4</accession>
    <name>A0A1E7NFM4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0001985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367037.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5078"/>
    <dbReference type="EnsemblBacteria" id="OEV39487">
        <property type="protein sequence ID" value="OEV39487"/>
        <property type="gene ID" value="HS99_0001985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="562" mass="62428" checksum="B867911E91B5F7C2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFR1</accession>
    <name>A0A1E7NFR1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF5132 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285863.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5077"/>
    <dbReference type="EnsemblBacteria" id="OEV39488">
        <property type="protein sequence ID" value="OEV39488"/>
        <property type="gene ID" value="HS99_0001990"/>
    </dbReference>
    <dbReference type="OMA" id="TTAGKTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033456">
        <property type="entry name" value="DUF5132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17195">
        <property type="entry name" value="DUF5132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="12334" checksum="EE2103AA6FC229B2" modified="2017-01-18" version="1">MPPVVPPFLVGLIVAPLAKRLLKPLVRGVVKTSVGIAMEVKKAAHEAGENIHDLAAEVAADMVAAQATSSDTAIRSGDGQRTSGNGAPIGAKEEGAAARPEGDPRAPKIRATAGAGTTAGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG24</accession>
    <name>A0A1E7NG24_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3 9 10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HS99_0003050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 10">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3 9 10"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550384.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2804"/>
    <dbReference type="EnsemblBacteria" id="OEV39660">
        <property type="protein sequence ID" value="OEV39660"/>
        <property type="gene ID" value="HS99_0003050"/>
    </dbReference>
    <dbReference type="OMA" id="WRADRND"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199114" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="42"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="13">
        <location>
            <begin position="245"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OEV39660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="40469" checksum="11C708D90B1706BD" modified="2017-01-18" version="1">MKSPHPESRKVGRLRRSVGKVPLLAPALAVVLLLPGTADADTVTTNRTGTDGGYFFSFWTEGTGSVSMSLNGGGHYGTSWTNAGNFVAGKGWSTGSRNPVTYSGTWSTNGNAYLSLYGWSTDPLVEYYVVDNYGSYKPTGTYKGTVTSDGGTYDIYETTRYNAPSIEGIRTFNQYWSVRRDRRTGGTITVGNHFDAWAGHGMNLGTLNYEILATEGYRSSGSSDITVGGSPGGGSGGGTPGGGITPGAVYTLTDAAAGRVLDEPAGQNGNGTPLQVWDANGGAANQRWRADRNDDGSYTLTNVASGRALDEPSGRTGNGTRLQVWDSSGAANQHWRADRNDDGSYTLTNVASGRALELPGGQTANGTPVQVWDSNGGANQHWNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGQ6</accession>
    <name>A0A1E7NGQ6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0000845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3634"/>
    <dbReference type="EnsemblBacteria" id="OEV39805">
        <property type="protein sequence ID" value="OEV39805"/>
        <property type="gene ID" value="HS99_0000845"/>
    </dbReference>
    <dbReference type="OMA" id="WSVGHRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199139" description="acidPPc domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="21874" checksum="43092D7C347A911F" modified="2017-01-18" version="1">MAAGLALVLFAALAALLAEQSWAPFGFERDADDWSAAHRPSAARTVAVVITSLGSGTVPYLLALAAGAVALLALAEPRPPRRAVVLLLAPVLWLLLGQLLRAGLMQLFARPRPPRLDWATDASGFSFPSGHSFTSAVCAGLLALSVARARPAAARAATVIAVVFAAAVGLSRIYLGVHWPLDVLGGWLLATAWLALGTAAARGVARASRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A176SES1</accession>
    <name>A0A176SES1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DDE endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0004520</name>
        <name evidence="3" type="ORF">HS99_0008910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, Assembly and Comparative Genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558517.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000187_gene7525"/>
    <dbReference type="EnsemblBacteria" id="ARF81637">
        <property type="protein sequence ID" value="ARF81637"/>
        <property type="gene ID" value="B6264_24470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82025">
        <property type="protein sequence ID" value="ARF82025"/>
        <property type="gene ID" value="B6264_26880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34609">
        <property type="protein sequence ID" value="OEV34609"/>
        <property type="gene ID" value="HS99_0008910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37091">
        <property type="protein sequence ID" value="OEV37091"/>
        <property type="gene ID" value="HS99_0004520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18032" checksum="7CAB3985C6E6BD44" modified="2016-09-07" version="1">MRVGGRGSGRVSVAGLIAMRPGSRTRLCHRLRCHTGRKGERRSLSERDYIGLIDGVHQLVKAPIVLVWDRLNTHVSHAMRDLINARDWLTVFILPAYAPELNAVEYLWAHVKRSLANLASVAPERLAALVRNRLKQLQYRSDVLDGFLAGTGLSLDLPPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVE7</accession>
    <name>A0A1E7MVE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553900.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000081.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene7006"/>
    <dbReference type="EnsemblBacteria" id="OEV32407">
        <property type="protein sequence ID" value="OEV32407"/>
        <property type="gene ID" value="HS99_0017085"/>
    </dbReference>
    <dbReference type="OMA" id="TERMDTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19120" checksum="6A72B7C72152476A" modified="2017-01-18" version="1">MTAAGTEGPPISAQHRDTAVRRLQEAYAEGHLSDEELDERLRTALTATTPGGLDSALAALPEPPPDATATITGTGTGGWIRRRGAWSVPRVLKVASALGRVRLDLSRAVIAHPVVDIELHLGTGGANVIVPRDAVVDLSGLHAGLRAPRYRPRQPARAGGPTIRISGGLGLGRLRIRHARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK5</accession>
    <name>A0A1E7MVK5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290097.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000250.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1213"/>
    <dbReference type="EnsemblBacteria" id="OEV32466">
        <property type="protein sequence ID" value="OEV32466"/>
        <property type="gene ID" value="HS99_0017450"/>
    </dbReference>
    <dbReference type="OMA" id="AFEPASW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7462" checksum="42398726CA924299" modified="2017-01-18" version="1">MSENVDLTGASWSKSSYSGNGGQCVEVAFDFQGLMPVRDSKDPQGPALVFPSEAWKSFVSAVRSGEFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVK7</accession>
    <name>A0A1E7MVK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetracycline repressor protein class H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385483.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6869"/>
    <dbReference type="EnsemblBacteria" id="OEV32293">
        <property type="protein sequence ID" value="OEV32293"/>
        <property type="gene ID" value="HS99_0016410"/>
    </dbReference>
    <dbReference type="OMA" id="SALYWHF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="213" mass="22874" checksum="9B90F892DBE4E147" modified="2017-01-18" version="1">MKLTKERIVDAGMAVFAEVGYQNLSMRQVADRLDAHAGSLYYHVRGKEELLALMADRVCRRAYDAGTAALAALPSSAAWPDRVEAQATALRLSIKEHPGGAQLLAESPGKLSTGALSLMERLLGTLLDGGLPAEHCGIAADTLLSHVTGFVLQEQNQPSSPPAVTAELYADLRERFPLVMGELIPRIGQDEKFTRSVRLLCTGFAALKPPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW03</accession>
    <name>A0A1E7MW03_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287902.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3831"/>
    <dbReference type="EnsemblBacteria" id="ARF78348">
        <property type="protein sequence ID" value="ARF78348"/>
        <property type="gene ID" value="B6264_04925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32612">
        <property type="protein sequence ID" value="OEV32612"/>
        <property type="gene ID" value="HS99_0015155"/>
    </dbReference>
    <dbReference type="OMA" id="GTGFRTT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="31064" checksum="F42792CE1DE690AE" modified="2017-01-18" version="1">MTDRTQSAARAREARRRRYLMCRPTHFEVTYRINPWMDPAKPVDTDLAVAQWEKLRALYLELGHEVELIDPLPGYPDMVYAANGATVVDGKVLGARFRNVERSAEGPAYLAWFRDNGFTELHDPEHINEGEGDFLVAGNLILAGTGFRSEPPGHAEAQEFFGCPVVSLELVDERYYHLDTALAVLSEDEVMYNPRAFSPGSRAVLERLYPDAVLASEEDAAVFGLNAVSDGRHVVLPEAATGLARELRKRGFEPIGMDLSELLKGGGSVKCCTLEVREAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW25</accession>
    <name>A0A1E7MW25_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0015215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287879.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000432.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3843"/>
    <dbReference type="EnsemblBacteria" id="ARF78337">
        <property type="protein sequence ID" value="ARF78337"/>
        <property type="gene ID" value="B6264_04865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32624">
        <property type="protein sequence ID" value="OEV32624"/>
        <property type="gene ID" value="HS99_0015215"/>
    </dbReference>
    <dbReference type="OMA" id="RDNIRAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="673" mass="73649" checksum="AB2D65F171521AF7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWF3</accession>
    <name>A0A1E7MWF3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0016075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554620.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000135.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6104"/>
    <dbReference type="EnsemblBacteria" id="ARF78189">
        <property type="protein sequence ID" value="ARF78189"/>
        <property type="gene ID" value="B6264_04005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32766">
        <property type="protein sequence ID" value="OEV32766"/>
        <property type="gene ID" value="HS99_0016075"/>
    </dbReference>
    <dbReference type="OMA" id="RKVMVPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18919" checksum="C0A7E674DBC46BEB" modified="2017-01-18" version="1">MQFGRTYEEFEVGAVYKHWPGKTVTEYDDHLFCLLTMNHHPLHMDTNYAEKTTDFGKNVVVGNYIYSLLLGMSVPDVSGKAIANLEIESLRHIAPTFHGDTIYGETTVLDKWPSKSKDDRGIVYVETKGYKQDGTVVCVFRRKVMVPTETYIKARGGEQPGRPEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWG7</accession>
    <name>A0A1E7MWG7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0016030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554627.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000786.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6113"/>
    <dbReference type="EnsemblBacteria" id="ARF78196">
        <property type="protein sequence ID" value="ARF78196"/>
        <property type="gene ID" value="B6264_04050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32759">
        <property type="protein sequence ID" value="OEV32759"/>
        <property type="gene ID" value="HS99_0016030"/>
    </dbReference>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="707" mass="74504" checksum="BA33CA9F7F8D0C99" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR1</accession>
    <name>A0A1E7MWR1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RimK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000082">
        <property type="protein sequence ID" value="OEV32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063738007.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000098_gene36"/>
    <dbReference type="EnsemblBacteria" id="OEV32854">
        <property type="protein sequence ID" value="OEV32854"/>
        <property type="gene ID" value="HS99_0039860"/>
    </dbReference>
    <dbReference type="OMA" id="NAFPGIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RimK" evidence="1">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="264" mass="27697" checksum="C3A15E1D4767376C" modified="2017-01-18" version="1">MRVGLITGNPGHPVLAAAAELLVRRGCRVEVVASGGSGASLADVYLLKARTPQALALARELEQRGAAVVNSAAATELCQDRVRMAELARGAGLPFATTVAAGRPAEIADPAYPFVVKSRHSRRHDLVALVDGAARLRELAQRWPEEEVVTQPYVPGSGWDQKLWVVDGQVFAARRRSELSSGDGGSADAGEWEPPAGLAALALRVGEVFGLEVYGVDLLDGVAEPVIVDVNAFPGVRGRPGAPEALAGLSAGMSWPSTKCRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWX0</accession>
    <name>A0A1E7MWX0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552578.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5787"/>
    <dbReference type="EnsemblBacteria" id="ARF81337">
        <property type="protein sequence ID" value="ARF81337"/>
        <property type="gene ID" value="B6264_22685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32927">
        <property type="protein sequence ID" value="OEV32927"/>
        <property type="gene ID" value="HS99_0013665"/>
    </dbReference>
    <dbReference type="OMA" id="WASTAPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="24401" checksum="5D781AE5E0B9C40C" modified="2017-01-18" version="1">MADPDASLDFKVKPDELDGCGQSAQHIGGLIPGETAKITDPCSQAAGRTTSSIAWIGYDAPQNIVPEAADDTYAKNAEDKLHGFEVGLHATHDGNIANNTILGHSYGTTTIGYTMKDKGLPVDNVVLVGSPGAGVDTARDLHIDPSHVYAAQSQGDPIGLAPAVDPGGLADNAWDNMKSGFGFGGDDHHLIHGRQTTAPEFGAQILPTDPNGGHSDYWNANSPTLPAMGRIIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA9</accession>
    <name>A0A1E7MXA9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290648.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000719.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5611"/>
    <dbReference type="EnsemblBacteria" id="OEV33076">
        <property type="protein sequence ID" value="OEV33076"/>
        <property type="gene ID" value="HS99_0014540"/>
    </dbReference>
    <dbReference type="OMA" id="CINLFGA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198519" evidence="1">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11279" checksum="3CCE2CEF9F17557D" modified="2017-01-18" version="1">MRLRNAALAVASAVALVLAVPMSANAAVGEFLYKVGPGVPAGIADPQSGKCINLFGATEKDPAFAPENLTTSTATVFLDFDCNGDTFYVMNPGKILGDRLKLRSVIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC1</accession>
    <name>A0A1E7MXC1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290629.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000267.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5601"/>
    <dbReference type="EnsemblBacteria" id="OEV33086">
        <property type="protein sequence ID" value="OEV33086"/>
        <property type="gene ID" value="HS99_0014595"/>
    </dbReference>
    <dbReference type="OMA" id="EHPRHAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21108" checksum="69BBFB0220985BB1" modified="2017-01-18" version="1">MRIAVLGATGRVGRLIVEQGLQRGHEVVALVRRPQTGAVHGRPDVEVRRADVTAPAAFPDLTDVDVVLSALGIGKGDGPGALVAGARVLAEVPVRTLWLGALGSGPSVGAGGGIYQCIMKAFVGEELTEKAAADAIALDGGATVFHAPDLWTGGVSTGRRNIPLEDYAKPLLPPHASRATVAALMLDEAERPTRGARILVPVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL2</accession>
    <name>A0A1E7MXL2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552505.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5736"/>
    <dbReference type="EnsemblBacteria" id="ARF81387">
        <property type="protein sequence ID" value="ARF81387"/>
        <property type="gene ID" value="B6264_22950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32973">
        <property type="protein sequence ID" value="OEV32973"/>
        <property type="gene ID" value="HS99_0013920"/>
    </dbReference>
    <dbReference type="OMA" id="ELFAYFQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="44493" checksum="64D9A2F3282DE8DD" modified="2017-01-18" version="1">MSTGTARDLTDPGLYSQGEPHEVWRHLREHDPVHWQPNSGRGGGYWVVTRYADVERVLHDYSAFTSERGTLLNLLGRGDPAAGKQLAATDPPHHDRARIPLKQALAVKPLASFSDRIQAGIRDLLAPGADGQPFDFAVAMSQLPLVALGPILGLPTEDYPRLIRLAMMSTAEEDPEFQLPGGVEPTLKRGHREIFAYFSDLVRARLRNPGDDLISVLAETEVDGERISTGSVISNCYSMLLGSAGTLPHVPIAAIVELAGSPTYGDWAAHPELLDSGIEEALRWATPASNFMRYALHPVELSGVPVAEGDAVVAYLASANRDAKVFPDPDVFDIRRRPNRHLAFGVGHHYCVGSHLARLALRLLFTELFATFSSIEVVGEIERMHSTFLAGFKRVPVAGVPRRATVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL6</accession>
    <name>A0A1E7MXL6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290344.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000307.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3429"/>
    <dbReference type="EnsemblBacteria" id="OEV33169">
        <property type="protein sequence ID" value="OEV33169"/>
        <property type="gene ID" value="HS99_0014665"/>
    </dbReference>
    <dbReference type="OMA" id="AKIVFAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198529" evidence="1">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="180" mass="17809" checksum="76FF1C1A01D09CA2" modified="2017-01-18" version="1">MSSVGRKTVAVMAAALASLGAGSGVTASATTPSATSCSSGAQCPSLKPTRLTASQATLNVTQMQLENINAAASDAVTGEPIRGAKIVFATMGGRTLGMAYTDDTGIAAITAPEDLGPGTLQELLGGYEAALVGDGVHAPVGAHGAITVGTDQGPGVPNSPCQICSDRGLKQDVVPVDWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXQ0</accession>
    <name>A0A1E7MXQ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000072">
        <property type="protein sequence ID" value="OEV33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290319.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7097"/>
    <dbReference type="EnsemblBacteria" id="OEV33215">
        <property type="protein sequence ID" value="OEV33215"/>
        <property type="gene ID" value="HS99_0039200"/>
    </dbReference>
    <dbReference type="OMA" id="AFGRNGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="14727" checksum="58E1872889967911" modified="2017-01-18" version="1">MATVIFVDETTSGVRRDAWRLAVAEERLTLRELIRRRVHREVAEHDAGRSGAFHGPVQPTAAERTLNGDHRRPEDRAVDPERQFLDAVEAFGRNGFLVLVGDRQIEDLDAELDLRADTEVCFLKLVPLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYM6</accession>
    <name>A0A1E7MYM6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketoacyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5218"/>
    <dbReference type="EnsemblBacteria" id="ARF80640">
        <property type="protein sequence ID" value="ARF80640"/>
        <property type="gene ID" value="B6264_18570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33537">
        <property type="protein sequence ID" value="OEV33537"/>
        <property type="gene ID" value="HS99_0013350"/>
    </dbReference>
    <dbReference type="OMA" id="EILVGWQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="26950" checksum="B0E6CC1608C8E304" modified="2017-01-18" version="1">MSTVTTGDVALVTGATSGIGLASAERLARRGLSVFICARTAQGVAETVARLRGEGLEVDGLAADVRSAQDVSRVVRAAVDRFGAIGVLVNNAGRNGGGVTSTLTDELWQDVIDTNLTSVFRVTREVLTTGGMEAAGHGRIISVASTGGKQGVPLGAPYSASKAGVIGFTKALAKELAHTGTTVNAVCPGYVETPMAVRVRQAYAATWATTEEDVLSRFEQKIPLGRYSTAEEVAGMVDYLTTPDAASVTAQAINVCGGLGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA2</accession>
    <name>A0A1E7MZA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366555.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3766"/>
    <dbReference type="EnsemblBacteria" id="ARF78408">
        <property type="protein sequence ID" value="ARF78408"/>
        <property type="gene ID" value="B6264_05265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33780">
        <property type="protein sequence ID" value="OEV33780"/>
        <property type="gene ID" value="HS99_0037870"/>
    </dbReference>
    <dbReference type="OMA" id="GHGLWTA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="313" mass="33517" checksum="A64A189F75CF9ED5" modified="2017-01-18" version="1">MSGIHPTPHVTTPPGRTAARPHHWARLFLTGLLLWASTVLVTFFTDNTNLVPTIVLLGSFLVPATVVIRVYERYAADLGPDRILTCFGLGGVIGVLGASVLESYLLSPSVWMYVGVGLIEEAVKLAALVVVSRRLRISGLRDGLVLGATVGAGFAAFESAGYAFNAVLSIQGLSLDDLVETEILRGVLAPVGHILWTAIIGGVLFRARRGGRFRVTAPVVPTFLGVSLLHALWDSTSGIAVWLVARTTTSDFQRALFDLGYMPNPSSEQIHLYTAYDTTGLLVVSLGGLLWLRLLLRREPTAPIPAQSPSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA3</accession>
    <name>A0A1E7MZA3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="7" type="ORF">HS99_0038055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288023.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7696"/>
    <dbReference type="EnsemblBacteria" id="ARF78561">
        <property type="protein sequence ID" value="ARF78561"/>
        <property type="gene ID" value="B6264_06215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33749">
        <property type="protein sequence ID" value="OEV33749"/>
        <property type="gene ID" value="HS99_0038055"/>
    </dbReference>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="163" mass="18295" checksum="B4F3C4F0454EE7E3" modified="2017-01-18" version="1">MRRAVCPGSFDPIHNGHLEIIERASKLYDVVHVAVLINRNKQGMFTVEERIGLIEEVTAQFGNVVVESHHGLLVDFCRERGIPAIIKGLRAVSDFDYELQMAQMNHGLTGVETLFLPTSPTYSFLSSTLVKEVASYGGDVSHLLPETVHRRLVERIAERRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZE3</accession>
    <name>A0A1E7MZE3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0037690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283744.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000377.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4534"/>
    <dbReference type="EnsemblBacteria" id="ARF80391">
        <property type="protein sequence ID" value="ARF80391"/>
        <property type="gene ID" value="B6264_17065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33812">
        <property type="protein sequence ID" value="OEV33812"/>
        <property type="gene ID" value="HS99_0037690"/>
    </dbReference>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="17513" checksum="8F507C23FF0D2BA2" modified="2017-01-18" version="1">MRVYLGSDHAGYELKNHLVEWLKGAGHEPVDCGPHIYDAEDDYPPFCLRAAERTAADEDALGIVIGGSGNGEAIAANKVKGVRAALAWSVQTAELGRQHNNANVISIGGRMHTVEEATKFVEVFLNTPYSGEARHTRRIEMLSEYETTGELPPIPAHHPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZE7</accession>
    <name>A0A1E7MZE7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289098.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3786"/>
    <dbReference type="EnsemblBacteria" id="ARF82634">
        <property type="protein sequence ID" value="ARF82634"/>
        <property type="gene ID" value="B6264_05160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33789">
        <property type="protein sequence ID" value="OEV33789"/>
        <property type="gene ID" value="HS99_0037765"/>
    </dbReference>
    <dbReference type="OMA" id="QYWGGPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="15432" checksum="26DE445EAEE9D2A5" modified="2017-01-18" version="1">MTEIGRGTFSEETFFEQVGGEPTFRLLTRRFYEGVAQDELLRPMYPEEDLGPAEERMALFLMQYWGGPRTYSDRRGHPRLRMRHAPFKVDKAAHDAWLTHMRAAVASLELPAELEHQLLDYLVYAAASMINTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI1</accession>
    <name>A0A1E7MZI1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290390.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4393"/>
    <dbReference type="EnsemblBacteria" id="ARF80311">
        <property type="protein sequence ID" value="ARF80311"/>
        <property type="gene ID" value="B6264_16605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33848">
        <property type="protein sequence ID" value="OEV33848"/>
        <property type="gene ID" value="HS99_0037565"/>
    </dbReference>
    <dbReference type="OMA" id="GWDMHPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="1">
        <location>
            <begin position="119"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="429" mass="45256" checksum="1F8060D08B8093A6" modified="2017-01-18" version="1">MSQVEVDGTGATGGASFSAAARDAVEALLAPVDADLARRYPGDSGTRQPVHTVYVPADAFGADTVREWGRQALEAFDTHAGTPAELARALGVADDALLADVHARVRAKLEREPIEDLRIDFEDGYGPRPDAEEDAAAVRTAELVAAAVAEGGAPPYLGIRIKCMEAPVRARGIRTLELFLATLLANGGLPEGLVLTLPKVTYAEQVTALVRLLEDFERRAGLPAGRIGFEIQIETTQAILGPDGRATVALMIEAAEGRATGLHYGTFDYSASCGVSAAHQSMDHPVADHAKAVMQVAAAGTGVRLSDGSTNVIPTGSTEQVHAAWKLHHDLVRRSLARAYYQGWDMHPAHLPTRYVAVYSFYREGLAAAAARLAAYVAKAGGDVMDEPATARALSGYLLRGLDCGAVDPAEFTALTGLDRARLDALAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZK1</accession>
    <name>A0A1E7MZK1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="12" type="ORF">HS99_0037300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014138019.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6370"/>
    <dbReference type="EnsemblBacteria" id="ARF78756">
        <property type="protein sequence ID" value="ARF78756"/>
        <property type="gene ID" value="B6264_07345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33867">
        <property type="protein sequence ID" value="OEV33867"/>
        <property type="gene ID" value="HS99_0037300"/>
    </dbReference>
    <dbReference type="OMA" id="DTCLKWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="9531" checksum="1FD152F993CCB670" modified="2017-01-18" version="1">MDWRHRAVCREEDPELFFPIGNTGPALLQIEEAKAVCRRCPVMEQCLQWALETGQDAGVWGGMSEDERRAMKRRAARNRARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZU7</accession>
    <name>A0A1E7MZU7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366465.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000111.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2177"/>
    <dbReference type="EnsemblBacteria" id="OEV33956">
        <property type="protein sequence ID" value="OEV33956"/>
        <property type="gene ID" value="HS99_0010860"/>
    </dbReference>
    <dbReference type="OMA" id="LGIWWPS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1052" mass="108695" checksum="F15B1932527E7C61" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW2</accession>
    <name>A0A1E7MZW2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280242.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2210"/>
    <dbReference type="EnsemblBacteria" id="ARF77838">
        <property type="protein sequence ID" value="ARF77838"/>
        <property type="gene ID" value="B6264_01865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33980">
        <property type="protein sequence ID" value="OEV33980"/>
        <property type="gene ID" value="HS99_0011020"/>
    </dbReference>
    <dbReference type="OMA" id="GKPYIAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="36906" checksum="3E9E1628B26EB143" modified="2017-01-18" version="1">MGAEVAEVRTVLDGDGGLGRIVLNRPRALNSLTHGMITTIRAALDEWIADGRVRAVVLTGAGERGLCAGADLRAMHDEVRAGGAGTRAFFRDEYRLNALIARYPKPFVALMDGITMGGGIGLSAHSAVRIVTERSTIAMPETRIGLVPDVGGSRLLAHAPGELGTHLGLTSASMGPGDALLCGFADHFVPSERVSELLDALARSSDPAATVAAHAEPAPPAELAGQRDWIDACYAADTVEEIVERLLNSGVPEAKESAELVLGNSPTAVKVTLAALRRARALTTLEAVLDQEYRISCAALDGRDLIEGIRAQVIDKDRSPQWSPRTLSDVTEADVARFLAPREGDELGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N036</accession>
    <name>A0A1E7N036_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551792.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2278"/>
    <dbReference type="EnsemblBacteria" id="ARF77889">
        <property type="protein sequence ID" value="ARF77889"/>
        <property type="gene ID" value="B6264_02185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34031">
        <property type="protein sequence ID" value="OEV34031"/>
        <property type="gene ID" value="HS99_0011335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="42803" checksum="0FDA92F0036EB4F6" modified="2017-01-18" version="1">MGIFGRKKKQPAGLDIGGGTRLHIEASPQEIKRMVKDLRGRAEAGDVEAMADLGRMLEYQGKVEEAMRWHQQAAVAGDVDSAAWLADRLLKNGQITTGLDYLRLAARGGHLSATFNLGAILLSQDENSEEGARWMLRAAEAGHQKAIDHLGIDMAQVRAAREEVARDVAKAEQGDAEAAHRAASVLLDLGEVEQAEYLLELAANGGIADAAWELALRVHDRGDTPRAVELLEQAGRNGRPGGAKLAGIWLYTEGEPAAAVPLLRRAVAEGEELLTPVLGAALSAAGDLDGAEAVLRPAAEAGDWQAQYNLLAVLQQRAARTGGDRSTEEMWSLLSRATAGLHAQAQERLDAGEPQRAADLLLIGARAGDPAAQRSLGELLLAIDPKDPEGQEWLRRSGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0E2</accession>
    <name>A0A1E7N0E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0010635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1865"/>
    <dbReference type="EnsemblBacteria" id="OEV34145">
        <property type="protein sequence ID" value="OEV34145"/>
        <property type="gene ID" value="HS99_0010635"/>
    </dbReference>
    <dbReference type="OMA" id="PDCKQKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="50043" checksum="B6C5EE59B193FBEF" modified="2017-01-18" version="1">MDALAGGAGGPGSLGPLLATVLDALEAGTALRSGPLPAGSPAEIAALVAEGLSGTRGRGALARLTELLAYGAADPADPACAAHLHCPPLAVATAADLAVSALNPSQDSWDQAPAATALETALIAELAALVGYDPARAAGVLTSGGTESNLMGLMLARDQKLDGIVELDGIPAGVRPCILASAAAHFSVQRSAALLGLGERAVIAVPVDRQLRMSPEELERELAEVSWAGRTPIAVVATAGTTDTGAIDPLDAAADLAGRYGAWLHVDAAYGGGALLSDRLAPLLDGIARADSVSLDWHKLGWQPAAAGVFLVRRAETYVSLARRAEYLNPVDDEQAGYPSLLGRSLRTTRRADAFKLAVTLRTLGREGLGRLVDTCHELALAAAAAVRAEPSLELHSEPVLTTLLFRYRPPGPADEAAVDELNGQLRRLLLRTGRAVVGRTELPGEGAGRVRLKLTLLNPHTTVGEVGALLREVVGAGRKVAGERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0G0</accession>
    <name>A0A1E7N0G0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD_binding_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3714"/>
    <dbReference type="EnsemblBacteria" id="OEV34180">
        <property type="protein sequence ID" value="OEV34180"/>
        <property type="gene ID" value="HS99_0011885"/>
    </dbReference>
    <dbReference type="OMA" id="ITIPQWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="502" mass="55182" checksum="FD31B46016DB6822" modified="2017-01-18" version="1">MVLASELLRHGVQADVISNARRQSPHSRATILWPRILELLDRVGVGEKLVAAGHYFDQMNYYSNKKMVGLVRFDRLRGVGYPFAITIPQWRTEAVLEEHLEALGGTIRYDHAFVEGTQSEDTVHCVLRGPDGTSTSRSYDYVVGADGYNSTVRPAFGFEFAGRTMRTRLAITDAELVGETTSSEAAYYLTRTGNMVLAPLGGGIFRVGASVPDGYQGEPDRAFFERLLSERVPGERRLGEMKFSGVFTAHVRSASTYQRGRVFLVGDAAHAMSPSGAQGVNTGIQDAVNLGWKLAGVLRGDYRPGLLASYDRERRPAVETVAGLSTRLARIGLYSKPHQVIGRDIAYRFGSATQLLERVLAPKLAQVDTHYGPRPKRRGLVPGERLPLGWRACAAAPVLAVDRYTVLLWPGLEYRYDRWVQLVERLGEAVDRARVTDLGGRPPGPVLAKLGATPCALVVRPDGHLDRVVELDDREPEAAVRAVDRALDERLLPSPARALVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0Q1</accession>
    <name>A0A1E7N0Q1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0036700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000051">
        <property type="protein sequence ID" value="OEV34268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_051835465.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2598"/>
    <dbReference type="EnsemblBacteria" id="OEV34268">
        <property type="protein sequence ID" value="OEV34268"/>
        <property type="gene ID" value="HS99_0036700"/>
    </dbReference>
    <dbReference type="OMA" id="LFDFWSH"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="990"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2046"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1025"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV34268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2394" mass="256905" checksum="01B02EC6FCDAA363" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V7</accession>
    <name>A0A1E7N0V7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0036375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551331.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6407"/>
    <dbReference type="EnsemblBacteria" id="OEV34327">
        <property type="protein sequence ID" value="OEV34327"/>
        <property type="gene ID" value="HS99_0036375"/>
    </dbReference>
    <dbReference type="OMA" id="GMTTGHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="615" mass="65206" checksum="72F3AAF873421C66" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0X6</accession>
    <name>A0A1E7N0X6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386192.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6423"/>
    <dbReference type="EnsemblBacteria" id="ARF78711">
        <property type="protein sequence ID" value="ARF78711"/>
        <property type="gene ID" value="B6264_07075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34339">
        <property type="protein sequence ID" value="OEV34339"/>
        <property type="gene ID" value="HS99_0036460"/>
    </dbReference>
    <dbReference type="OMA" id="IIFIDIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="139" mass="15107" checksum="924D8EC8120B8CDE" modified="2017-01-18" version="1">MSGRVLVVDDSEVIRQLIRVNLELEGFEVVTAADGAECLEVIRRVKPDVVTLDVVMPRLDGLRTAARLRATPDTSGLPIAIVSACTPADLDLGEAVGVDGYLGKPFDPADLVALVRRLMRAEERPAGFRPERTERTDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M5</accession>
    <name>A0A1E7N1M5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558160.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000531.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82038">
        <property type="protein sequence ID" value="ARF82038"/>
        <property type="gene ID" value="B6264_26955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34598">
        <property type="protein sequence ID" value="OEV34598"/>
        <property type="gene ID" value="HS99_0008840"/>
    </dbReference>
    <dbReference type="OMA" id="LYLYSMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="168" mass="18414" checksum="C2B010E7D60CAF30" modified="2017-01-18" version="1">MSEQHELELRRLSSDDWPLWRELRLAALAEAPYAFGSTLADWQGPGDHEERWRSRLEIPGALDLVAVLDGTPVAMATGVPADEDPSAAELISMWVAPAARGRGVGDRLIAEIARWAADEGYRTLKLAVMPHNDAAIALYRRNGFADTDELGDLLDDGTIRELVLAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Y5</accession>
    <name>A0A1E7N1Y5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030598543.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000092.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81939">
        <property type="protein sequence ID" value="ARF81939"/>
        <property type="gene ID" value="B6264_26365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34697">
        <property type="protein sequence ID" value="OEV34697"/>
        <property type="gene ID" value="HS99_0009415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="119" mass="13111" checksum="A05BA05D10909873" modified="2017-01-18" version="1">MASKPPTDFEAITDALYVLAPTAFTAARNERADEVKKSDPQLAKAIRALHRPTVAAWAANLLAHRHHDLVRQLMDLGQALREAQEHLAGEQMRGLADQRRLHRSAARARRSSSTGTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N235</accession>
    <name>A0A1E7N235_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34742">
        <property type="protein sequence ID" value="OEV34742"/>
        <property type="gene ID" value="HS99_0009670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="210" mass="23322" checksum="E887630F69E00F59" modified="2017-01-18" version="1">MHPAPARSRLSPVQLGTLVTVTSTCQCGPATINGPGVRAAYYAYQRKIRAERTADGRQFRSRRTDFHPTNTLSYLAVHLDGDGAVRLEVAAAAEELERPQNLLVDELRWLADGRRFLHTEGFADGLMKIWLNPAVAVNGGCDPRPLAARHRFPYPVLADGGLSAPEPVRFLEYSAHLWDEVYFANRHMFAGGLFPNPDCRACFPVRLHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G4</accession>
    <name>A0A1E7N2G4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0009960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557006.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000298.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000058_gene3243"/>
    <dbReference type="EnsemblBacteria" id="ARF83074">
        <property type="protein sequence ID" value="ARF83074"/>
        <property type="gene ID" value="B6264_25785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34889">
        <property type="protein sequence ID" value="OEV34889"/>
        <property type="gene ID" value="HS99_0009960"/>
    </dbReference>
    <dbReference type="OMA" id="QFMSPEH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="56343" checksum="778CB8BD4C6BB231" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2S1</accession>
    <name>A0A1E7N2S1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4603"/>
    <dbReference type="EnsemblBacteria" id="ARF81883">
        <property type="protein sequence ID" value="ARF81883"/>
        <property type="gene ID" value="B6264_26025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34753">
        <property type="protein sequence ID" value="OEV34753"/>
        <property type="gene ID" value="HS99_0009735"/>
    </dbReference>
    <dbReference type="OMA" id="ILYTSQM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="286" mass="30676" checksum="31349E640C9D9452" modified="2017-01-18" version="1">MIIVTGATGKLGRRTVERLLERVPADRVGVSVRDPRKAQDLADRGVRVRQGSFDDPASLVHSFEGAEQLLLVSLDRTGQECVAGHRTAIDAAVQAGVGRILYTSQMGAAHDARFQACRDHAQTEDLLRATGLPWTALRNGFYASSALQFLEPARHAGDIALPADGPVAWTGHDDLAEATAVILAEEARFEGPTPPLTGPAALDFDTVAKIASQTTGRPFTRTVIPDDVFREQVLAHGAPAPIADLMLSIFAAARNGEFTAVDTTLAELIGREPATFRTHLERAWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U5</accession>
    <name>A0A1E7N2U5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558407.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35002">
        <property type="protein sequence ID" value="OEV35002"/>
        <property type="gene ID" value="HS99_0034255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198714" evidence="2">
        <location>
            <begin position="36"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="22694" checksum="9B4925A397D0AB55" modified="2017-01-18" version="1">MGRTARRAGGTAAAVVVVLVLGAAACTGQGGGADATVTGSRPRPVSTVNGAVLSEPAPPSAQWIVDELSEPGAYESSCPVPTRTDMIVLDSDDRHRTRAAVVWLGDGLQVCLAGISHGADGGGSTVSSGPLGDLTRGHWSAWMGRSFFAVFPGDAGTVVMEDDDDHLYGPVHQRVADFGAGRRATFVQYAFPGPLAPSGSPSGSPRARLCPSAGGGCRPAQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N389</accession>
    <name>A0A1E7N389_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285361.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000301.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4428"/>
    <dbReference type="EnsemblBacteria" id="ARF78463">
        <property type="protein sequence ID" value="ARF78463"/>
        <property type="gene ID" value="B6264_05615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35135">
        <property type="protein sequence ID" value="OEV35135"/>
        <property type="gene ID" value="HS99_0033640"/>
    </dbReference>
    <dbReference type="OMA" id="KPWCAGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="461" mass="48575" checksum="4D8953A6E535EC16" modified="2017-01-18" version="1">MTLNPTAPSPSSRRRPVAVPALLAALALTAACSNSSGGSGGGGGTAQTLTGDCAKYQPYAGHSGTTVTMFASILSPESDNLEKSWAEFSKCTGIKISYEGSNDFESQLPVRVAGGNAPDFAIIPQPGLLAQMVKSGKVVKPPAQTVTNQDKWSPVWKTYGSVDGTFYAAPMSANMKSLVWYSPKTFAAAGYEVPKTWADLMALSDRIAKAGGPKPWCGGIASGTATGWPATDWLEEVVLGTYGGDVYDQWVGHQVKFSDQKITTAMQTVADWMLNPAWVNGGYGDVKSIATTTFQDAGAPILTGKCAMLQQASFYEAQWPKGTKVAPDGDVFAFHLPAVNPAIANPVEGGGEFLAAFSGRPEVQAVQNYLSSSDWASSRVRTASGWVSANQGVDKSLYTDPIDKLSAEALTDPSATFRFDASDMMPAAIGSGQEWKSLTAWFAEGQSVQKVAGDIDAAWPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E2</accession>
    <name>A0A1E7N3E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1380"/>
    <dbReference type="EnsemblBacteria" id="ARF79267">
        <property type="protein sequence ID" value="ARF79267"/>
        <property type="gene ID" value="B6264_10365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35207">
        <property type="protein sequence ID" value="OEV35207"/>
        <property type="gene ID" value="HS99_0033335"/>
    </dbReference>
    <dbReference type="OMA" id="LFGHAQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="50098" checksum="3316540295DF14FD" modified="2017-01-18" version="1">MVRTVPTHTVPPGPADDVDMALMRESPLDFITGLARTYGDVTRHRADGDTVYLLNRPEYARHVLKDNGANYTKEGTPDDAMLRPLLGNGLLTSNGADWARQRHLTAPAFRPSAVRTFDTIVTDATAGMLERWRPSVEAGTPLEVDQHLTALTLGILTHAILGADIDGIGEGFGRAVDAVNRCIGHYVPTPDPDPADTARRYADFGRARVFLNTVTRTLIAARRAGGGSTAGGRAPGSSTAGGGSAGAGGDLLDTMMSSHHLVSDEDLRDQVLTIVMAGHETTAKSLTWTLYLLDRHPEELAKVREEVDRVLGGRPPTAADLADLPACRRAIQEAMRLYPPVWLISRRAAGPDVIGGYDVEPGTLVCVSQWVLHRHPEYWTEPDAYRPDRFDGADLPSHLYLPFGGGDRICVGQHFAMLEAVLVLASLLQSVRLELVEGFPVEPEALVTLRPKHGMTMIARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I8</accession>
    <name>A0A1E7N3I8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Valine dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0033520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-valine + NAD(+) = 3-methyl-2-oxobutanoate + H(+) + NADH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30763"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.23" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289494.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000522.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6145"/>
    <dbReference type="EnsemblBacteria" id="ARF79297">
        <property type="protein sequence ID" value="ARF79297"/>
        <property type="gene ID" value="B6264_10555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35234">
        <property type="protein sequence ID" value="OEV35234"/>
        <property type="gene ID" value="HS99_0033520"/>
    </dbReference>
    <dbReference type="OMA" id="TYVADMD"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043837">
        <property type="term" value="F:valine dehydrogenase (NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016211">
        <property type="entry name" value="Glu/Phe/Leu/Val_DH_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42722">
        <property type="entry name" value="PTHR42722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000188">
        <property type="entry name" value="Phe_leu_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000188-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="385" mass="40475" checksum="94B080B9F7064DB5" modified="2017-01-18" version="1">MTDVQTPATHPAPGVLSRIFRTEQDGAPGDGHEQVVLCHDRSSGLKAIIAIHSTALGPALGGTRFFPYASEEAALEDALNLSRGMSYKNALAGLDLGGGKAVIIGDPNKDKNEAMLRAYGRFVESLRGRYITACDVGTYVQDMDVIARETEFVTGRSPEHGGAGDSSILTAFGVFQGMRASAQARWGQPTLRGKRVGVAGVGKVGHYLVGHLVADGATVVVTDPFEAAVNRVRAAHPEVEVVADTTALLQAKLDVYAPCALGGALTDPVVAALSEFGTSIVCGAANNQLAHPGVEKDLSDRGILYAPDYLVNSGGVIQVADEIDGFNFERAKNKATKIFDTTLEIFTRAAADGVPPAVAADRLAEKRMREISALRTVLLPGARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N404</accession>
    <name>A0A1E7N404_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290485.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000227.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1587"/>
    <dbReference type="EnsemblBacteria" id="OEV35417">
        <property type="protein sequence ID" value="OEV35417"/>
        <property type="gene ID" value="HS99_0032140"/>
    </dbReference>
    <dbReference type="OMA" id="NSQLPYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="219"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="427" mass="44510" checksum="789033F7DCD5C825" modified="2017-01-18" version="1">MGAVMAGTEVARQAASASRRQLAVLLTAKTISDIGYALDFICLSVFVWEHSRSTLETGLVSVALYSGAIVGGRLGHRYGDRWDRRRMMIGADLARAGMLALLAVLPTGVQNWWLYPAVVVIGTGRSVFEATLSAATPVLAGPRTPSVNSALAGLKGVAFMVGMGLAAVLVPVAGYRWVFGLDAASYTLSAVVLLALRLRMREPDGRAAAARDRSGAWPLLVAAGVAGLVVLRGLDAFGSASQHVGLPLLGTELRPTEPAVVSGAVWGSWAAGLLLASFVLRPLAKRLVERAPAPVYCVATMVMSLGFIGVFWLDGWWPRLLAAAGAGLGDALSEITYKQSLQQLPDGRRGRAFGLSQITVNAGFMSGLLVTSLVLQPDWVAQWVLLLHGVPLLVAGWMAVGAARTARTAARAVGTVGPAAGTVGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N451</accession>
    <name>A0A1E7N451_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galactosylceramidase</fullName>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Galactosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0032170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1594"/>
    <dbReference type="EnsemblBacteria" id="OEV35471">
        <property type="protein sequence ID" value="OEV35471"/>
        <property type="gene ID" value="HS99_0032170"/>
    </dbReference>
    <dbReference type="OMA" id="VASDNLW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006683">
        <property type="term" value="P:galactosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001286">
        <property type="entry name" value="Glyco_hydro_59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172">
        <property type="entry name" value="PTHR15172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00850">
        <property type="entry name" value="GLHYDRLASE59"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="7">
        <location>
            <begin position="650"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV35471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="778" mass="82116" checksum="764F4A5FC2EE6EC9" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N470</accession>
    <name>A0A1E7N470_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome BD ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0031810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552771.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000289.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5531"/>
    <dbReference type="EnsemblBacteria" id="ARF79380">
        <property type="protein sequence ID" value="ARF79380"/>
        <property type="gene ID" value="B6264_11005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35491">
        <property type="protein sequence ID" value="OEV35491"/>
        <property type="gene ID" value="HS99_0031810"/>
    </dbReference>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="56333" checksum="F3D0D68ADD23F55E" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4M6</accession>
    <name>A0A1E7N4M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828837.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene960"/>
    <dbReference type="EnsemblBacteria" id="ARF80818">
        <property type="protein sequence ID" value="ARF80818"/>
        <property type="gene ID" value="B6264_19600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35622">
        <property type="protein sequence ID" value="OEV35622"/>
        <property type="gene ID" value="HS99_0006830"/>
    </dbReference>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="218" mass="24300" checksum="F30F061D99D48B06" modified="2017-01-18" version="1">MSTADEQAQPLETDSPQITRIVIAEDEALIRLDLKEMLEEEGYTVVGEAGDGETAVRLVKELKPDLAIFDVKMPVLDGLSAAEQIHEEHLAPVLMLTAFSQRELVDRARDAGAMAYIVKPFSKSDLVPAIEMAVSRYTEMRALEKEIGDLTQRLETRKLVDRAKGVLQTKFGLNEPAAFRWIQKTSMDRRMTMAAVAEAVIEEGEAQDRKKAEEGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4S7</accession>
    <name>A0A1E7N4S7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0007195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388332.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000275.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene887"/>
    <dbReference type="EnsemblBacteria" id="ARF80884">
        <property type="protein sequence ID" value="ARF80884"/>
        <property type="gene ID" value="B6264_19970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35685">
        <property type="protein sequence ID" value="OEV35685"/>
        <property type="gene ID" value="HS99_0007195"/>
    </dbReference>
    <dbReference type="OMA" id="DWYGGPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="47276" checksum="37BE2A2BA112F604" modified="2017-01-18" version="1">MSTTIETSATSLLRFATAGSVDDGKSTLVGRLLHDSKSVLADQLEAVERVSLGRGQEAPDLALLTDGLRAEREQGITIDVAYRYFATPRRRFILADTPGHVQYTRNMVTGASTAELAVVLVDARNGVVEQTRRHAAVAALLRVPHVVLAVNKMDLVDYAEPVFAAIAEEFSAYAASLGVKDVLAVPISALAGDNVVEPSAHMDWYGGPTLLEHLETVPVGSDPSREPARFPVQYVIRPQTEEHPDYRGYAGQLASGVLRVGDAVTVLPSGLTTTVAGIDALGRESDIAWAPQSVTVRLADDLDISRGDLIAAGAAPVPTKDIVATVSHLNERPLRAGDKVLLKHTTRTVRALVKEISYRIDIDTLQRRSGAEGLNVNDIGHVKLRTAEPLALDDYTDNRRTGSFLLIDPADGTTLTAGMAGEAFEAVHGDDAPGASEEEDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4X1</accession>
    <name>A0A1E7N4X1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0007580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386000.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000188.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene812"/>
    <dbReference type="EnsemblBacteria" id="ARF80944">
        <property type="protein sequence ID" value="ARF80944"/>
        <property type="gene ID" value="B6264_20350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35740">
        <property type="protein sequence ID" value="OEV35740"/>
        <property type="gene ID" value="HS99_0007580"/>
    </dbReference>
    <dbReference type="OMA" id="LAMFEFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17989" checksum="6324959A3F7BCDCF" modified="2017-01-18" version="1">MDTYALATSLAVDYPVLNIFWTMLELFLWILWFFLLFKIITDIFRSHDIGGWGKAGWLVLVIFLPLIGILVYLIARGQGMGKRDLEQAQQADAALRAYIREAAATPTATPAATPARTPAATPAAGAAGGGGGRGHVEDLARLADLRDRGAISDEEYQRAKEKLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4Y8</accession>
    <name>A0A1E7N4Y8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0007695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551020.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene789"/>
    <dbReference type="EnsemblBacteria" id="ARF80966">
        <property type="protein sequence ID" value="ARF80966"/>
        <property type="gene ID" value="B6264_20475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35756">
        <property type="protein sequence ID" value="OEV35756"/>
        <property type="gene ID" value="HS99_0007695"/>
    </dbReference>
    <dbReference type="OMA" id="DKMFLDN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="382"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="545" mass="58536" checksum="35659D81258AF2A7" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N505</accession>
    <name>A0A1E7N505_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0007760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281485.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000094.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene777"/>
    <dbReference type="EnsemblBacteria" id="ARF80976">
        <property type="protein sequence ID" value="ARF80976"/>
        <property type="gene ID" value="B6264_20535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35765">
        <property type="protein sequence ID" value="OEV35765"/>
        <property type="gene ID" value="HS99_0007760"/>
    </dbReference>
    <dbReference type="OMA" id="QWEKDGI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="41712" checksum="CADECF6BAF481A28" modified="2017-01-18" version="1">MQREIFTEQHEDFRATVKAFLAKEVLPHYDRWEKAGIVDRSVWLAAGRQGLLGIAAPEEYGGGGTPDFRYAAVLAEEFARAGASGLAIGLHNDIIGPYLTSLATEEQKRRWLPGFCSGELITAIAMTEPGTGSDLQGIRTQAVDRGDHFLLNGAKTFISNGILADLVIVVARTTPEGGAHGLSLLAVERGTPGFERGRNLDKIGQKAQDTAELFFEDVRVPKENLLGELNGGFIHLMQNLAQERLTIAAAAIAGAEYLVEITTEYVKQREAFGRPLAKLQHVRFEIAELATECAITRTFVDRCITEHNRYALTPADASMAKWWATELQKRTADRCLQLHGGYGYMSEFPVARAFTDGRIQTIYGGTTEIMKEIVGRSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N530</accession>
    <name>A0A1E7N530_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR03084 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387000.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000611.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene755"/>
    <dbReference type="EnsemblBacteria" id="ARF80992">
        <property type="protein sequence ID" value="ARF80992"/>
        <property type="gene ID" value="B6264_20645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35782">
        <property type="protein sequence ID" value="OEV35782"/>
        <property type="gene ID" value="HS99_0007870"/>
    </dbReference>
    <dbReference type="OMA" id="FPWYGPP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017518">
        <property type="entry name" value="CHP03084"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03084">
        <property type="entry name" value="TIGR03084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="28142" checksum="91AB61DDF8E100A5" modified="2017-01-18" version="1">MTDPNAAGDVLHGLLADLRAESAVLDALVAGLPADGWAGPTPAEGWTVAHQIAHLAWTDDWTALAARDPEGFTASLGGSFTALLATGADPVEEGAREGAAAAPAALLARWRTGRAEVQDALAAAPADARLPWFGPPMKPASMATARLMETWAHGQDVADALGVTREPTARLRHIAHLGLRTLGFAFAAHGLPAPEHPVRLELTAPDGSTWAFGPADAADVVTGPALDFCLLVTQRRHRDDLALTATGPVATAWLPIAQTFAGPPGKGRAAASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N559</accession>
    <name>A0A1E7N559_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">HS99_0006650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280433.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000573.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5388"/>
    <dbReference type="EnsemblBacteria" id="ARF80786">
        <property type="protein sequence ID" value="ARF80786"/>
        <property type="gene ID" value="B6264_19415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35593">
        <property type="protein sequence ID" value="OEV35593"/>
        <property type="gene ID" value="HS99_0006650"/>
    </dbReference>
    <dbReference type="OMA" id="HTEPENI"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21510" checksum="B3B9EC5EAEC10188" modified="2017-01-18" version="1">MSRIGRVERTTKETSVLVEMDLDGTGKTDISTGVGFYDHMLDQLGRHGLFDLTVKTDGDLHIDTHHTIEDTALALGAAFKQALGDKVGIYRFGNCTVPLDESLAQVTVDLSGRPYLVHTEPEGMAPMIGSYDTTMTRHILESFVAQAQVALHVHVPYGRNAHHIVECQFKALARALRYAAERDPRAAGILPSTKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5C0</accession>
    <name>A0A1E7N5C0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0008245</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000056_gene3350"/>
    <dbReference type="EnsemblBacteria" id="OEV35844">
        <property type="protein sequence ID" value="OEV35844"/>
        <property type="gene ID" value="HS99_0008245"/>
    </dbReference>
    <dbReference type="OMA" id="ITWVFGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="12">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="12">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="43112" checksum="34C3ED6D173D1F49" modified="2017-01-18" version="1">MTVSDTRGQQTSDQPPQDGGRPTGPPPERGGGLLMGRPFGVPIYVTPSWFVIAALITWVFGGQLGDVLPELGSGVRYLLAFFFAVAFYASVLVHELAHTLVALRYKLGVRRIQLQFFGGVSEIENEAESPWREFWLAFVGPLLSLVLGGVFYLALRAVELSSVPGVLLTGLMVSNLVVAAFNLLPGLPLDGGRMLRAVVWAVSGRAMTGTVAAAWIGRALAIVVLVGLPLVSASRSGERTTTDTLVDAVLAAVLAAIIWNGATGSLRNARLKEALPELRLRDLARRTVEVTADTPLGEAMRRAREAQAGAVVVVDGRGDPIAIVRESAVRAVPEHRRPWVAVGPLARDLEPGLRLDVDLGGEDLLRAVQATPAGEYLVVEADGRVYGVAALTDIERRLTAAVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5K0</accession>
    <name>A0A1E7N5K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0007785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene772"/>
    <dbReference type="EnsemblBacteria" id="OEV35977">
        <property type="protein sequence ID" value="OEV35977"/>
        <property type="gene ID" value="HS99_0007785"/>
    </dbReference>
    <dbReference type="OMA" id="KHTAAIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="20987" checksum="FEBB5CC30EB0E940" modified="2017-01-18" version="1">MLEANGMKVTAAVENGEQLLAAVAADRPDIAVVDVRLPPTFTDEGLRAALAARQAHPGLPVLVLSQFVEQLYARELLAGSSGGIGYLLKDRVLDGAQFLDAVRRVAQGGTAMDPEVITRLLTHNSSAGPVSTLSPRERQVLGLMAEGRSNAAIAQQLVITERAVAKHTASIFVRLDLQPSDDDNRRVLAVLAYLNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5L1</accession>
    <name>A0A1E7N5L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0007945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389573.1">
        <property type="nucleotide sequence ID" value="NZ_CP020567.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene740"/>
    <dbReference type="EnsemblBacteria" id="ARF82967">
        <property type="protein sequence ID" value="ARF82967"/>
        <property type="gene ID" value="B6264_20720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35982">
        <property type="protein sequence ID" value="OEV35982"/>
        <property type="gene ID" value="HS99_0007945"/>
    </dbReference>
    <dbReference type="OMA" id="WGAHAAT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="476" mass="49520" checksum="867A5E6EBC34F4FE" modified="2017-01-18" version="1">MVLGAGPTGENVADRTVAAGLRTVIVEAELVGGECSYWACMPSKALLRPAAALDDARAVGGAREAVGGGQLDAAAVLARRDSFTSHWKDDGQVQWLRDTGIELVRGHGRLAGVRTVAVEADDGTERVLTARHAVAVCTGSRPVLPSDVPGLADAHPWTNREATGSPTVPGRLAVVGGGVVGVEMACAWRALGSEVVLLVRGDALLPRMEPFAGELVAEGLRGAGVDLHFGTEVTSLERAGATGPVVLSLNDGERLTEGERLSADEVLYATGRAPRTADIGLEQVGLRPGSWLDVDDSCTVLGVDGEWLYAAGDVNHRALLTHQGKYQARITGAAIAARAQGRALDTSRWGAHSASADLAGAPQVVFTQPEVAAVGLTLAAAERLGLRVKAVDQEIGDVAGASLYADGYRGRARVVFDLDREVIVGACLVGPAVAELLHSATVAVVGEVPIDRLWHAVPAYPTISEVWLRLLEGCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N627</accession>
    <name>A0A1E7N627_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281052.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1E7N627"/>
    <dbReference type="STRING" id="1894.JOER01000018_gene5008"/>
    <dbReference type="REBASE" id="196448">
        <property type="entry name" value="M.SauDM1ORF15140P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80074">
        <property type="protein sequence ID" value="ARF80074"/>
        <property type="gene ID" value="B6264_15140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36128">
        <property type="protein sequence ID" value="OEV36128"/>
        <property type="gene ID" value="HS99_0031160"/>
    </dbReference>
    <dbReference type="OMA" id="HNANFAW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="552" mass="61276" checksum="1B9C5FF71D202FE8" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N639</accession>
    <name>A0A1E7N639_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0008695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286287.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7307"/>
    <dbReference type="EnsemblBacteria" id="ARF81135">
        <property type="protein sequence ID" value="ARF81135"/>
        <property type="gene ID" value="B6264_21470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35923">
        <property type="protein sequence ID" value="OEV35923"/>
        <property type="gene ID" value="HS99_0008695"/>
    </dbReference>
    <dbReference type="OMA" id="YQDDAES"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="28938" checksum="564D84B200B567C0" modified="2017-01-18" version="1">MRNVLKFTSVLATAGLALSLAACGSSGSSSSDPNAPLKVVASPTPHGQVLKFVNDNLAAKAGLKLDIKEVTDYVTPNTAVQDGSADANYFQHVPYLDDFNKKNGTDIVSVETVHLEPLGVYSKKVKSINDLPSGATVGLPNDATNEGRALKLLADNKLITLKEGAGTAATPADVTGNPKNFKWKELEAAQLPRSIADLDAAVINGNYALDSGLKPATDALVLEKAEGNPYANILAVKKGKENDPRVKKLAELLHSDEVKKYIDDTFQGSVIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N691</accession>
    <name>A0A1E7N691_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">HS99_0030680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000334.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8064"/>
    <dbReference type="EnsemblBacteria" id="OEV36210">
        <property type="protein sequence ID" value="OEV36210"/>
        <property type="gene ID" value="HS99_0030680"/>
    </dbReference>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="442" mass="45707" checksum="662E074DC676BEAA" modified="2017-01-18" version="1">MSHVSYPYEAPQSQSLFDRASVVTPGGVNSPVRAFRAVGGTPRFMVSGTGPYLTDADGREYVDLVCSWGPMILGHSNPAVIDAVQRAVALGTSFGTPGQGEVELAEEIVARVAPVEQVRLVSSGTEATMSAIRLARGFTGRAKVVKFAGCYHGHVDALLAAAGSGVATFGLPDTPGVTGAQAGDTIVLPYNDLAAVEQAFAAHPGEIACVITEASPGNMGVVPPLPGFNAGLARLCRDNGALFVSDEVMTGFRVSKAGWYGLEAANEGWAPDLLTFGKVMGGGFPAAAFGGRADVMAHLAPAGPVYQAGTLSGNPVATAAGLAQLRGCTDEVYATVDRVSAEISGLVSEALTKEGVAHRLQTAGNMFSVFFTEAAVTNYEEARTQEAYRFTAFFHAMLAEGVYLPPSAFESWFVSASHDERAIERIAAALPAAARAAAAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6W3</accession>
    <name>A0A1E7N6W3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0029995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554793.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7744"/>
    <dbReference type="EnsemblBacteria" id="ARF83129">
        <property type="protein sequence ID" value="ARF83129"/>
        <property type="gene ID" value="B6264_28670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36415">
        <property type="protein sequence ID" value="OEV36415"/>
        <property type="gene ID" value="HS99_0029995"/>
    </dbReference>
    <dbReference type="OMA" id="QWIIAGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="487" mass="50008" checksum="1EA6AF21E019CE03" modified="2017-01-18" version="1">MPEKERFDAAGRRVLLVCVAGGFTTLIDQSVLNTSIPALRGTLHAQPAHLQWIVAGYSLAFGLALIPGGRLGDVKGRKWFFVIGLALFTLVSLVSATATDPTVLIAARLLQGAGAGLVNSQMIGTLQDVFDGQLRARALGMYAVTGSLAFALGPPIGGLVLAAAGPELGWRITFLLNVPFGLATLALAVRHLPRPRPAARHADLDLLGLLLVGALTLALMLPFVRPPGLAGRLAFAAAVLALLGALIGWQRRYARTGGHPLIHPALTRSAPYALGTAIAMAQFGFSLAASLVLTMFLQDGLGLSPMGAALVSLPSALAMATASGLAWRVVQRLGRRTVTVGMTGSALAMLLSGIVAQWAPAVVLPWLLALLQLLGGASVGLMGSTNQAYVLRHAPAEAAGVSGAILQMAQRIAAAVAVSALSGVYLRETAGGGGHRSAYLTAGLVCAAVAGLAVLASVFAGRVSGRDRTPEKPDETVTVSPGRTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6X8</accession>
    <name>A0A1E7N6X8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289738.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000255.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene207"/>
    <dbReference type="EnsemblBacteria" id="ARF82244">
        <property type="protein sequence ID" value="ARF82244"/>
        <property type="gene ID" value="B6264_28210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36451">
        <property type="protein sequence ID" value="OEV36451"/>
        <property type="gene ID" value="HS99_0029395"/>
    </dbReference>
    <dbReference type="OMA" id="LIATWTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="396" mass="41771" checksum="59C1B7843902241F" modified="2017-01-18" version="1">MPATPTPPLIRRLPPEAWVALAWCVAVAYPALALRDTGWRQYGGAAAHGGLPFTLGDTAIAFAGAALVRRVPVLSVAVLLIATWTETDGWAAKHQVPPTALLAVDVALFVITARGTRRSSRAAFALVMTFLVLHIGMVPGNTVGVFTGTRIGSADGAALLALVAWLAGRSLRQNREHAEALSSRAAVEAVTAERLRIAREMHDTVAHSLGIVALQAGAARRVIHRRPERAEQALGEIEAAGRETLAALRRMLVALRQADGEVSDTVPHGLADLDRLAETTTAAGVRVEVRRSGEPGPLPPEIDLSAFRIIQESVTNVVRHAEVRDCLVTVGRTAGELSVEITDRGRGHGAAPGSGFGLAGLRERVALLHGEFEAGPRPDGGFRVAARLPIPGEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y3</accession>
    <name>A0A1E7N6Y3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4879"/>
    <dbReference type="EnsemblBacteria" id="ARF83139">
        <property type="protein sequence ID" value="ARF83139"/>
        <property type="gene ID" value="B6264_29070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36404">
        <property type="protein sequence ID" value="OEV36404"/>
        <property type="gene ID" value="HS99_0029590"/>
    </dbReference>
    <dbReference type="OMA" id="TKQYVAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="512" mass="53093" checksum="7420C167D42A2E49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N743</accession>
    <name>A0A1E7N743_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0029505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289759.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene184"/>
    <dbReference type="EnsemblBacteria" id="OEV36489">
        <property type="protein sequence ID" value="OEV36489"/>
        <property type="gene ID" value="HS99_0029505"/>
    </dbReference>
    <dbReference type="OMA" id="KLECENR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="222" mass="23458" checksum="0D28F202FD50E4E9" modified="2017-01-18" version="1">MIRVLVADDEPLIRAGIRMILGSADDIEVVAEAADGREALDLARAHRVDVVLLDIQMPVMDGLTALRELGRVAPGARAIILTTFGERENVLRAVTEGGAGFLLKDTAPNELIQAVRAAAGGNAFLSPAATRHIVDSLASGRSASATARRAEARRRLEVLTGRELEVLGLLGEGLSNADAGARIHMSEATVKTYVSRILAKLGCENRVQAALLARDAELDSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N758</accession>
    <name>A0A1E7N758_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA family drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0030315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283619.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2614"/>
    <dbReference type="EnsemblBacteria" id="OEV36303">
        <property type="protein sequence ID" value="OEV36303"/>
        <property type="gene ID" value="HS99_0030315"/>
    </dbReference>
    <dbReference type="OMA" id="FVVREHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="454" mass="45684" checksum="42D27A6FA0EE90D5" modified="2017-01-18" version="1">MTDTAVTPLIRPGLALGVLAGALALDVSGLGVLNAALPSIGTRFDLSDTTLQWVMTAYAVTFAGFLLVGGRLADVLGRRRVFEAGVAVFTASALVGAVAPNTAVLLGARAVQGIGAALSGPAALALLSEAFPAGPARNRAFSVYAAVGAASFSGGVMLGGVLTQLLGWRSVLWFSVLLGAGVLAVTRIGLPDGAGHSGRLDLPGAVAGTLGLTLLVVGVSSGGATAWIVLGAAALCLVLFVVREHRTADPVLPLGLFRLTSVQSASLAAFLQYMGSVGMLFFAPLYLQGMLDYSPFESGLALVPMSLAVFLTANFATGRLLARYTPRTLMAVGLVLIGVGTGLWTATPHSGGYVTYVLPGLVLSGVGQGLNFPSMTTAGLSGVPAEQQGVAGAVNVVTQQIGASVGVALMVLVAGTREDQLGGYHLAYVTAAVACLLGAAVIAVGRRTRAARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N781</accession>
    <name>A0A1E7N781_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0028600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289041.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1491"/>
    <dbReference type="EnsemblBacteria" id="ARF79204">
        <property type="protein sequence ID" value="ARF79204"/>
        <property type="gene ID" value="B6264_09980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36494">
        <property type="protein sequence ID" value="OEV36494"/>
        <property type="gene ID" value="HS99_0028600"/>
    </dbReference>
    <dbReference type="OMA" id="NAMDLWV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="377" mass="37764" checksum="E434D4F89DD35A3A" modified="2017-01-18" version="1">MKLQRNGRSKALAIGAMALVSSLSLAACGSDNNTNTASGGSNGSSAAAAAINCGKAGTLLGAGSTAQAPAIDVWKTNFGSSCSGTTVNYSGGGSGAGVQQFNQGKVAFAGSDFALKPADVDASKAVCTGGKAIDLPMVAGLVSLVYNVEGVDNLVLDGPTAAKVFDSQITKWNDPAIAALNPGAKLPDAEIQTFHRSDDSGTTFNLTSYFAKTSGGAWSAEPSKAWKGKGGQSANGSAGVSAQIKQVKNSIGYAELSYAQTNNLKSAKIATGAAQPVEATAANAANTIASSTVSGTDGDLALSLDYGTKADNAYPIVLVTYEIACDKGNKAETLDTLKSFLTYTISDGAQKSIGDKGYVPMPAAIGDKVKAAVGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A2</accession>
    <name>A0A1E7N7A2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0029115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289699.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000269.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7918"/>
    <dbReference type="EnsemblBacteria" id="ARF79116">
        <property type="protein sequence ID" value="ARF79116"/>
        <property type="gene ID" value="B6264_09470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36582">
        <property type="protein sequence ID" value="OEV36582"/>
        <property type="gene ID" value="HS99_0029115"/>
    </dbReference>
    <dbReference type="OMA" id="WISGSIW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="348" mass="35503" checksum="51DAF7B59DAA8581" modified="2017-01-18" version="1">MTTVALRGYSVVRAGRASFLLHRRSALAAVGLLLALTVTVVASLCLGESTVSPGEVVKVVLGQPSPDELVVGEFRLPRVVVGLLVGAALGLAGALVQTVARNPLASPDVVGVTWGATATVVGLMAYGVVGSTGQAPYAAVGGGLVAGLLVYALAWRRGLHAQRFVLIGIGISVALSSLTSVFLTKGDGFQAQAAKVWMTGSLNGSGYDQAGRLAWVLLAALPVALWAARAQRSISFDDATAVGLGLRLDRIRLGMALLGVVLASCAAGAAGPVDFVALMAPQIALRLARSAQVPLFCSALTGALVVVVADLIARRLLAPTELPVGVVTGMVGAPYLMWLLIRSRRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K0</accession>
    <name>A0A1E7N7K0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278864.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2500"/>
    <dbReference type="EnsemblBacteria" id="ARF81503">
        <property type="protein sequence ID" value="ARF81503"/>
        <property type="gene ID" value="B6264_23620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36676">
        <property type="protein sequence ID" value="OEV36676"/>
        <property type="gene ID" value="HS99_0028330"/>
    </dbReference>
    <dbReference type="OMA" id="YPVPDDM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="31209" checksum="C446705D4E607744" modified="2017-01-18" version="1">MIDARRLRTLRAVADHRTVTAAAAALYLTPSAVSQQLAALEQETGHHLLAREGRGVRLTAAGEILLGHADAVLAQLERAEADLAAYSAGVAGEVTVASFATGISHVLAPAIGLLAGRAPGVRLKVLDAEGDASLPMVLDGRADLAVAVEYRGAPRADDARLTRVPLYAEPFEAVLPLAHPLAAESGPLAVAALADEPWIGPYPGNPCHDVVLLACEHAGFQPRLLHSSDDFRAVVALASAGSGVALVPRSALRGVDLARVSVRPVDSELATRRVFAAVRAGADGHPLIRPVLDSLAEAAASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R0</accession>
    <name>A0A1E7N7R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552937.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000433.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4752"/>
    <dbReference type="EnsemblBacteria" id="OEV36736">
        <property type="protein sequence ID" value="OEV36736"/>
        <property type="gene ID" value="HS99_0027315"/>
    </dbReference>
    <dbReference type="OMA" id="EPTHGED"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="42469" checksum="C4410A39B3B27236" modified="2017-01-18" version="1">MSQDIRDFLTPCCELLALGEPTHQEPAFGRVRNRLFAQLVERGFRSIALETDRVAALAVDDYVRHGAGTLDAVLDEGFTHGFGAQPGNRELVAWMREFNRDRGPAEQLAFHGFDTPTENTTAPSPRGYLEHARDYLRHHLPDHLRLDVDIAELAGEDERWSREQAVLDAASSPGETPEAVRLRRIADDLLTQLYLRAPELIEAGSRAEWFRARTRLQAGLGLLRYHAQVAVRGLGLSDRVSGLLGLRDALMAQNLLDIRAIEAGRGPTLVFSHNLHLQQAPSAWAGGELECRWNGAGRIVGPLLGERYVFVAGSLGRSEVLGLAEPVPGTYEALVGQGVDAAWALVEPPAPGEGRARSDTAPQQGYAFDRASFAGASAVLHIGDGTAAATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N800</accession>
    <name>A0A1E7N800_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0027590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552998.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000220.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4809"/>
    <dbReference type="EnsemblBacteria" id="OEV36774">
        <property type="protein sequence ID" value="OEV36774"/>
        <property type="gene ID" value="HS99_0027590"/>
    </dbReference>
    <dbReference type="OMA" id="RPRPWPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="28261" checksum="BDF44D34B9766FA7" modified="2017-01-18" version="1">MTRLQTRPATEVLVTARGEVSLAAPEYARTKLLAALERLDEPVLAARVKLTQEADHAVAKPSIAQATVDLNGRPVRAHVAATTMQEAVDLLQDRLNARIARLRTHRHDRHHNEAHAAAGHEHRPQRRALGTEERRIERHKTYSLARQSAWAAVFELEAMDYDFHLYTDTVTNCDSVVYRDGTAGEYRISSAGPAPEAEAGISVSTAGVPEITVAEAVARLDLGGLPFVFFTDASTGRGNILYHRYDGHYGLITPADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N802</accession>
    <name>A0A1E7N802_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386610.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000428.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4826"/>
    <dbReference type="EnsemblBacteria" id="ARF82432">
        <property type="protein sequence ID" value="ARF82432"/>
        <property type="gene ID" value="B6264_29335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36788">
        <property type="protein sequence ID" value="OEV36788"/>
        <property type="gene ID" value="HS99_0027675"/>
    </dbReference>
    <dbReference type="OMA" id="IARPWRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="250" mass="28003" checksum="31A9F15E9DDAEA1C" modified="2017-01-18" version="1">MSGSATRVPRACRGAWWARAARAVWRYVRRAPGTYIWLAILLATTEVIRHVDAATADRILERRSTNLHHLQVSPVRVLATSALWIAGGGWLGYFALYNLFHVPAERWLGTLRWLSVAVLAHVGATYLSEGVLGWAIHRGLAAPKAVYTLDYGVSYALAGVVGVLTYLVVRPWRYLYLAGVLAVYVLGLHQGRDYTGIGHLSAVLIGLACYPLTRERPGEFDPVASARALRRWLRLRRWLRQRSRPWPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N895</accession>
    <name>A0A1E7N895_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0027045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6841"/>
    <dbReference type="EnsemblBacteria" id="ARF78634">
        <property type="protein sequence ID" value="ARF78634"/>
        <property type="gene ID" value="B6264_06645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36920">
        <property type="protein sequence ID" value="OEV36920"/>
        <property type="gene ID" value="HS99_0027045"/>
    </dbReference>
    <dbReference type="OMA" id="LNWGGVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="514" mass="51843" checksum="C7D6901CF91B5DCC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L8</accession>
    <name>A0A1E7N8L8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000079_gene5974"/>
    <dbReference type="EnsemblBacteria" id="OEV37008">
        <property type="protein sequence ID" value="OEV37008"/>
        <property type="gene ID" value="HS99_0004025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="38" mass="4445" checksum="4954BD9FFB51BD88" modified="2017-01-18" version="1">MECGINRLKRHRAVATRYDKLAVRYEATVLIAAINEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8Y2</accession>
    <name>A0A1E7N8Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555762.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000740.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6682"/>
    <dbReference type="EnsemblBacteria" id="ARF81624">
        <property type="protein sequence ID" value="ARF81624"/>
        <property type="gene ID" value="B6264_24390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37104">
        <property type="protein sequence ID" value="OEV37104"/>
        <property type="gene ID" value="HS99_0004600"/>
    </dbReference>
    <dbReference type="OMA" id="EIPGILW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="247" mass="26633" checksum="A497F8BB072225FE" modified="2017-01-18" version="1">MHVTSEQRFDDDVLEREFILDGIPGFLWTPESASASAPAPLIVISPPPLGLDKMYPRLAGRARYYAAEYGFAVATIELPGSGDRPRLAVLDQARADLRRTVEAGEPVSGEIVDALILPLVEKAVPEWRATLDALLARPEIGGPVGYEGGIISIGVRLAAIEPRIAAAGLFAGSFVPATIVEEAREVTVPLQVLLQWDDEGNDRQAALDLFDAFGSREKTLHANMGGHTGVPKFELDAGARFFARHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N972</accession>
    <name>A0A1E7N972_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556579.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37194">
        <property type="protein sequence ID" value="OEV37194"/>
        <property type="gene ID" value="HS99_0005125"/>
    </dbReference>
    <dbReference type="OMA" id="HGVQMMN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="25"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="120" mass="12994" checksum="DD7412EA37E3DFF5" modified="2017-01-18" version="1">MHQHSHGYAEPSDLQRARQVGRLAPEEFAAWQSFQEVVDRGNGSVPRKYRELVAIAVALTTQCSYCLDVHTAQARRHGVTAEELAEVIFVAGAVRAGGALAHGLQAMKLYDGHPVTSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9D8</accession>
    <name>A0A1E7N9D8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555145.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1286"/>
    <dbReference type="EnsemblBacteria" id="OEV37278">
        <property type="protein sequence ID" value="OEV37278"/>
        <property type="gene ID" value="HS99_0005645"/>
    </dbReference>
    <dbReference type="OMA" id="KHRWGGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="375"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="591" mass="65100" checksum="41B1221D44E9A207" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9K1</accession>
    <name>A0A1E7N9K1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366184.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000134.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5418"/>
    <dbReference type="EnsemblBacteria" id="ARF82481">
        <property type="protein sequence ID" value="ARF82481"/>
        <property type="gene ID" value="B6264_29665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37366">
        <property type="protein sequence ID" value="OEV37366"/>
        <property type="gene ID" value="HS99_0006190"/>
    </dbReference>
    <dbReference type="OMA" id="DHPWPER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="315" mass="33635" checksum="F119FF46DA5F5551" modified="2017-01-18" version="1">MLPFDLPVDVALGRPVTDFPSGGGLSLEPKWDGWRALLRTGPDSRVFSWHGTDLTRAMADVAHTARRLPEAVYDGELLAVTDDGTVSFTLLQTSAGKGPKPGAGFSVVFVAFDLLATGNDTTDLRGQAYRERRERMLALLDGAPAGIRPTPATGDDHGALAWVGSLGGAIEGVVAKPLGRPDLPRYGSAWTKWRRRHTADAVITGITAAANPNQQAAVLSRPDTDGRLRAVGVSLPLTPELRRELAPQLHPAADDQLAELPGTVGGLPGSPPVSYLPVVPEIVVEILVDQDRPEFGRYRHRPQIVRVRAGPTPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R9</accession>
    <name>A0A1E7N9R9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acidPPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0005215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37437">
        <property type="protein sequence ID" value="OEV37437"/>
        <property type="gene ID" value="HS99_0005215"/>
    </dbReference>
    <dbReference type="OMA" id="ARSFAMV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198910" description="acidPPc domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="279"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="42780" checksum="BE7373F420CDC075" modified="2017-01-18" version="1">MAAGLTSPAFGSTAVDALPPTTSTAAPGSGRSVVEWNRELITILSGPKAQPSTVHPTRSFALLQAAEYDAVVSITRTAPAYLFSVPAPQGARADVAADQAAHDVLVALYPAERAGVDRQLSSQLSAVADGARKQAGIGVGAAVARQLISLRSADGSSAEPPQFTPGSQPGDYRPTPPDFPAPVFTNWGSVKPFVLTSGNQFRPAAPPAVGSAEYAAALNEVKGLGSKTSTTRTPDQTAAAKFWAAAPVWNVWNQVAQGLVTSGNASLEKAVKVFARLDLSLADTAIAMYDAKYAYHVWRPVTAIRLGDTHDNPGIVGDPGWTPLLPTAPDPSYPGAHGALSQAAATTLAGIYGAQHRLTVTSKGVTRTFAGFQDAATEAWLSRVWSGQHTAIDNQAGQQLGTQVAEFVAHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U0</accession>
    <name>A0A1E7N9U0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0006175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5421"/>
    <dbReference type="EnsemblBacteria" id="OEV37460">
        <property type="protein sequence ID" value="OEV37460"/>
        <property type="gene ID" value="HS99_0006175"/>
    </dbReference>
    <dbReference type="OMA" id="APEPYIY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="23600" checksum="99C9933684B60445" modified="2017-01-18" version="1">MFPDQGPTGGGTPVTIIGTHLTGTTAVHFGNRLATHVVVVDDNEITCVTPAGQGVVNVTVTTPGGTSFPVPFYYIPPPRITALHPSAGPVAGGTTVTIEGRNLQTVTTVTFGTATLVPTVLSDSQITVTTTPAAPGTVPVVVTTVGGVADDATYTYLAPPSATAISPVTGPAAGGTTVTLTGTGLATATNVAFGTTSAAFVVVSDTLINATAPAHTAGAVEVTVATPGGSATAPEPYIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U7</accession>
    <name>A0A1E7N9U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556539.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6153"/>
    <dbReference type="EnsemblBacteria" id="OEV37438">
        <property type="protein sequence ID" value="OEV37438"/>
        <property type="gene ID" value="HS99_0005220"/>
    </dbReference>
    <dbReference type="OMA" id="ARLMLKY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18740" checksum="AB8397A7BCFF8435" modified="2017-01-18" version="1">MTTNEPDHPDHPDHRTAEDLLNAVGPAFGRLRRTSLLEVENPISAKDLSRTLVLNLVQQHTQDSGKEVTVGAIAELLGVDPSVASRMVSDSIKTGYLTRAASQQDGRRTVLHLSPAGTELMARLRRHQRDAYDCITADWNERDRLEFARLMLKYVDSLDRLAERAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9W4</accession>
    <name>A0A1E7N9W4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552655.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7934"/>
    <dbReference type="EnsemblBacteria" id="ARF79101">
        <property type="protein sequence ID" value="ARF79101"/>
        <property type="gene ID" value="B6264_09385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37472">
        <property type="protein sequence ID" value="OEV37472"/>
        <property type="gene ID" value="HS99_0025970"/>
    </dbReference>
    <dbReference type="OMA" id="HTTWRAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33858" checksum="AFA8806CA9B3ECBC" modified="2017-01-18" version="1">MVQQDPPGGVEAGLLPELFWRADKASLDGQRETLRWHRGLIAMLVVAALIGSLPGPDHKGDSDIKPLFSVAAFLVAGYFWSRLRRSNPQGRWYEARAAAESVKTLAWKYSVRARPFDGEAESADADRGYLLQVEDVLRAFENPEIVPPGSVPEITEEMRRARADSLTARRTLYLRTRVEGQRTWYRSRAESCESQAVSWGLGIATLIIIGAAAAIAQATGALEVHIFGASSAAAAAIIAWTQLKQLRPLAAAYQLAARELENVGNQLSDLDLKAPDAELRWARMAAEAEDAVSREHTTWRARRAFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9W7</accession>
    <name>A0A1E7N9W7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline D-peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552679.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7956"/>
    <dbReference type="EnsemblBacteria" id="ARF79086">
        <property type="protein sequence ID" value="ARF79086"/>
        <property type="gene ID" value="B6264_09285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37487">
        <property type="protein sequence ID" value="OEV37487"/>
        <property type="gene ID" value="HS99_0026070"/>
    </dbReference>
    <dbReference type="OMA" id="IFARARH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="362" mass="38907" checksum="65E2383E6E7FD030" modified="2017-01-18" version="1">MSENTTQDRPDLQKAVQDVVDVGFAGIQMRVYDESGEWAGSAGVHKLGGSAKPSTEGQFWIGSTTKTFVATLVLHLVADGAIGLDSPVAEHLPRFGLDERITVRMLLQHTSGLYNCTGELDADGTFVPGLPSVGKAWVENRFHNYRPDELVRFALTKPARFEPGTDQSYSNTNYTLAALLVEALSGRSYAEEMQRRILRPLGLRDTVVPGDSPDIPGPHAHGYYRYQDGEEWKVVDVSRQNSSLLTGSGDMISTTRDLHVFFAGLLGGRLLPAALLDEMRTPHGPLGYGLGLFVQELGPENGDVTIVHHNGGAPGGYGALMISTPDGSRTLTAGLTTGDSDADPAKEFPKALNGLIAAVFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Z1</accession>
    <name>A0A1E7N9Z1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033347773.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7973"/>
    <dbReference type="EnsemblBacteria" id="ARF79071">
        <property type="protein sequence ID" value="ARF79071"/>
        <property type="gene ID" value="B6264_09205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37502">
        <property type="protein sequence ID" value="OEV37502"/>
        <property type="gene ID" value="HS99_0026150"/>
    </dbReference>
    <dbReference type="OMA" id="RGAVQWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="25023" checksum="BAD40585A6479BDA" modified="2017-01-18" version="1">MEEIPDAPGQDETAGPPPLLIEAVGYAENRHWEVAPGAWLIDGDGPARCSCGDPRCALPGAHPMDADWARRASAGPGAVRRWWTERPRASILLPTGRSFDVLDVPETAGCLALARMERMDLQLGPVAVLPSSPGRLGRRLHFLVLPGVAAKLPEMLRKLGWPPGRLDLVARGEGDWTVAPPSRVGSTGYAQWARSPSESNRWLPDAAELISPLAYACGREAPAQQLQAAQPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAS9</accession>
    <name>A0A1E7NAS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78069">
        <property type="protein sequence ID" value="ARF78069"/>
        <property type="gene ID" value="B6264_03275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37797">
        <property type="protein sequence ID" value="OEV37797"/>
        <property type="gene ID" value="HS99_0024720"/>
    </dbReference>
    <dbReference type="OMA" id="DNAMAET"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="35097" checksum="150CD14E7D9553FE" modified="2017-01-18" version="1">MKLIDEHQDRFGAEPVLRELHIPASTYYRWRHDVAEPCERKRHDAELTEHIRRIHADSGETYGSPRVHAVLRREGTRVGRKRVERLMRQAGIQGVSPRRPRSFTRRDPAADLAPDLVQRDFTAVAPNRLWVADISLIPTREGPWWLATIRDAFSRRIVGWHTSERADADLVLTALEYALHGRPVEPGQLVHHSDHGCQYTSIKLTTRLLKAGIEPSMGSVGDSFDNALAENFWSVLKTECVRRTTFETRTDADLALFAYIDGWYNTRRIQKRLGWLSPDEYEAKFYADQATAEPVTVEPPTPVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ2</accession>
    <name>A0A1E7NAZ2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6002"/>
    <dbReference type="EnsemblBacteria" id="OEV37849">
        <property type="protein sequence ID" value="OEV37849"/>
        <property type="gene ID" value="HS99_0025070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="11690" checksum="07A1EE5D2B52540D" modified="2017-01-18" version="1">MQWWDRAQRFRAYWNLWGDHLPLKILLSPYRAIVAPLVKYIESLDHQRPGLTLTVILPEIVVRHWRHRLLRNRLAARLRRALRSLPRVVVTTVPFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAZ4</accession>
    <name>A0A1E7NAZ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0024515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386877.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000551.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000087_gene3449"/>
    <dbReference type="EnsemblBacteria" id="OEV37861">
        <property type="protein sequence ID" value="OEV37861"/>
        <property type="gene ID" value="HS99_0024515"/>
    </dbReference>
    <dbReference type="OMA" id="NCGPLGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="PTHR16557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="24741" checksum="00633A872AA3D565" modified="2017-01-18" version="1">MFDDRPDDPPGAGPAARVRSEPAPGAVLLPDWLDLAAKLRLVAACREWARPPAGLHSVRMPTGGVMSVRMVSLGWHWYPYGYARVAEDGAPVKPFPALLGELARRAVADAYGERIGEIAGAAAYEPDTAIVNHYPHGAKMGLHQDRDERANAPVVSLSLGDDCLFRLGNTRTRNRPWTDLELHSGDLLVFGGPARFAYHGVVRTLPGTADPALGLVGRLNVTIRQSGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBU9</accession>
    <name>A0A1E7NBU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287411.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000552.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene471"/>
    <dbReference type="EnsemblBacteria" id="ARF78844">
        <property type="protein sequence ID" value="ARF78844"/>
        <property type="gene ID" value="B6264_07870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38171">
        <property type="protein sequence ID" value="OEV38171"/>
        <property type="gene ID" value="HS99_0023585"/>
    </dbReference>
    <dbReference type="OMA" id="LNSHHDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="38560" checksum="C985B02344157F27" modified="2017-01-18" version="1">MSSPNPTPLDLTLDGGTLTARLVDFPSVSGDEQALADAVEAALRGYPHLTVDRYGNNVVARTNLGRAERVVLAGHLDTVPIADNLPSYVEGDLLYGCGTSDMKSGVAVALRLAATLPEPNRDLTYVFYDCEEVEAHRNGLGHLAKDRPEWLAADFAVLMEPSDAMVEGGCQGTLRAQVRLTGVRAHAARSWLGDNAIHRAAEVLTRLADYRPRRVEIDGLEYREGLNAVRIDGGVAGNVIPDECVITVNFRYAPDRSEAEAEKHVREVFDGFELTVTDFAPGALPGLAQPAAKAFLAATGGQARAKFGWTDVARFSALGIPAVNYGPGDPNFAHKRDEHCSLTAIAETEDRLRAWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX4</accession>
    <name>A0A1E7NBX4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366700.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000511.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000078_gene7125"/>
    <dbReference type="EnsemblBacteria" id="OEV38154">
        <property type="protein sequence ID" value="OEV38154"/>
        <property type="gene ID" value="HS99_0023470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="PTHR14140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="15394" checksum="B58D7765A8CE09F4" modified="2017-01-18" version="1">MEVGQVFANRRALSDAQVHRPLQAGTSGIRERGAESVVVGWVGWNEDDRDHGDEIVFTGRGGRALDAGRQVEHRRFERGNAALVTSMTTARPVRLVRFEGGGRAPGYRYGGLFRVEECWCEKGRSGFLICRYRLVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG5</accession>
    <name>A0A1E7NDG5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1767"/>
    <dbReference type="EnsemblBacteria" id="OEV38725">
        <property type="protein sequence ID" value="OEV38725"/>
        <property type="gene ID" value="HS99_0020570"/>
    </dbReference>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="37574" checksum="482E473D08CFA4B6" modified="2017-01-18" version="1">MLGLGPRAERRRRALPAGILRLPTIGVDIGGTKVVAGVVDGEGKVLEKLRTDTPHKSKSAKVVEDVIVELVLQLADRHDVHAVGIGAAGWVDADRSRVLFAPHLNWRNEPLQQALSERLRFPVIVENDANAAAWAEWRFGAGRGEDHMVMLTLGTGIGGAVVRDGYVDRGKYGLAGEFGHMQVVPGGHRCPCGNRGCWEQYSSGNALVRDARELVAEESPVVQPLLARAGGTVEGITGPLVTEAAQDGDPTAVELLYEVGTWLGVGIANLAAGLDPGRFVIGGGVSEAGDLLLGPARDTFRRTLTGRGFRPEATIVHAALGNEAGLVGAADLARQVARRFRTIKRRRVERSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDM9</accession>
    <name>A0A1E7NDM9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Disulfide bond formation protein DsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000495.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7319"/>
    <dbReference type="EnsemblBacteria" id="ARF81146">
        <property type="protein sequence ID" value="ARF81146"/>
        <property type="gene ID" value="B6264_21560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38738">
        <property type="protein sequence ID" value="OEV38738"/>
        <property type="gene ID" value="HS99_0018830"/>
    </dbReference>
    <dbReference type="OMA" id="VLDVWCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="166" mass="18063" checksum="C022F93D088EFF4A" modified="2017-01-18" version="1">MIDGSLPRLEFWCDLQCPDCRTALDDVRALRAQYGDALPVELRHFPLEKHKHAYAAAEAAEEAFDQGLGWPFVEALLARVEDLDARGQQVLLEVAREVGADVEEIDTALIDGRHMLTVDADQAEGKAIGVTGTPTYVIGGQLLDGGKNQEGLRERIVAVIEAARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE09</accession>
    <name>A0A1E7NE09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000945.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83369">
        <property type="protein sequence ID" value="ARF83369"/>
        <property type="gene ID" value="B6264_31110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38941">
        <property type="protein sequence ID" value="OEV38941"/>
        <property type="gene ID" value="HS99_0017655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="519" mass="55473" checksum="7C9FFD68832ECD7D" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE69</accession>
    <name>A0A1E7NE69_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0017785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557311.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4322"/>
    <dbReference type="EnsemblBacteria" id="OEV38964">
        <property type="protein sequence ID" value="OEV38964"/>
        <property type="gene ID" value="HS99_0017785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="224"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="405" mass="41760" checksum="696A51D1D35A9AF9" modified="2017-01-18" version="1">MLVSDDTRPPGYREVFRERDFRVLWAAHALLNLGEVMKALALSALVYNRSGSPLLSGIAYVAGLLPQVFGSAALLSLADRLPPRLTMAAWDAARAAGAAVLALDVLPVPGVLALSTLYGLFDPVPAAMKTALLPELMGERRFVLAQSLMNVTVGAAQICGFAVGGALLALLGPVVTLWVVCGGALLSAAVLRLGLRTRPPRGAGGSAITPARALSTTWTVNRALWADVRVRRLLLALCLPACWIVGAEATMISYADEIGSPRAVGALLTAAALGMLIGDTLVGRFATRRRRNRWALPLSVLLGAPYLLFAAQPGIAAAAGLAALASIGFGYSLCLQESFVDVVPVESRGQAFGLAASGLMSCQGIAAGLTGAVAELARPSAGIAVAAAASLLCTALLVRVLRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE78</accession>
    <name>A0A1E7NE78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38938">
        <property type="protein sequence ID" value="OEV38938"/>
        <property type="gene ID" value="HS99_0017635"/>
    </dbReference>
    <dbReference type="OMA" id="HNWFRGG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="33094" checksum="C9080E1B4CAE31BA" modified="2017-01-18" version="1">MNDVPDLGPMPQRVTVSAEQAGRLVAEQFPQWASLPVTAVESGGWDNRTFRLGDTMVLRLPSAQEYALAVEKEHRWLPELARALPLPIPVPLAMGRPGAAYPFAWSVYGWIDGTPATFESVVDPIRFAEGLADFVAALRSIDASQGPQPGKHNWFRGATLRTYEVQALGALDELRGHIDVAPAYEVWTQALEAQWDGTDVWFHGDLAKGNLLLEDGQLVAVIDFGTCGVGDPACDLAIAWTLLSADGRDVFRKRLGVDDATWARGRGWALWKTLVSYANSLSEDGADARDTRRVLSAILTDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEA8</accession>
    <name>A0A1E7NEA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83261">
        <property type="protein sequence ID" value="ARF83261"/>
        <property type="gene ID" value="B6264_30445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39030">
        <property type="protein sequence ID" value="OEV39030"/>
        <property type="gene ID" value="HS99_0018175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="12438" checksum="59F70DB790141354" modified="2017-01-18" version="1">MLRRKDGPGGLLQFAWDVTTADFVQAEATGREEAMAAYPFGAEMFFQDYLALITGRLQVWDVAGGAMECWHIGRPLDSLVYAFFGIYGEHQRPDLAALSYATMAAGITAPAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NET0</accession>
    <name>A0A1E7NET0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0000320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550146.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3527"/>
    <dbReference type="EnsemblBacteria" id="OEV39211">
        <property type="protein sequence ID" value="OEV39211"/>
        <property type="gene ID" value="HS99_0000320"/>
    </dbReference>
    <dbReference type="OMA" id="VIRIIRM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="445" mass="47564" checksum="8A6D164D616C72E0" modified="2017-01-18" version="1">MTDHTAAAGSCPFPHAAAAAAAAEPVVEQGACPAGPARRSFVRAALGAGAGAAVLAGGAFGLGAEPAAAGDTHQTKSGAVPFHGDHQAGITTPAPGYAAFVSCQVIAQDRKGLEDLFRTLTERIRFLTAGGTPPDLGVGAPPSDSGILGPVVPTDNLTVTVGVGASLFDDRFGLAKAKPVKLTPMKTFPNDNLRADELHGDLSLQICADRQDTVLHALRDITRHTRGGMQILWRIDGFQNQSRPDGAQRNLLGFKDGIVNPDTTSTREMDRLIWVNDGMGEPAWATGGSYQVIRIIRMLIEFWDRVKLSEQEKMFGRRRDTGAPLDGHQENDAPDYGKDPDGKAIPLNAHIRLANPRTADTDTSRILRRGFNYDRGVDKAGNLDMGLVFCCYQQDVVRQFEATQTRLIDEPLVDYISPTGGGYFFVLPGVKDDADWLGRGLLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF10</accession>
    <name>A0A1E7NF10_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0018440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39073">
        <property type="protein sequence ID" value="OEV39073"/>
        <property type="gene ID" value="HS99_0018440"/>
    </dbReference>
    <dbReference type="OMA" id="ADHTEER"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="11634" checksum="F8C2E0AAE50428D2" modified="2017-01-18" version="1">MHATGQAGGRLAFTVRMRADQFTMSAGSKEDSPGLRRGFVPRADGTEERTYGSASTGGFDAVEWSQRVAEHHGDVTEAMRAWLVETGRAVEDADIQYLEVRGWISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF82</accession>
    <name>A0A1E7NF82_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1499"/>
    <dbReference type="EnsemblBacteria" id="OEV39332">
        <property type="protein sequence ID" value="OEV39332"/>
        <property type="gene ID" value="HS99_0001055"/>
    </dbReference>
    <dbReference type="OMA" id="EPDPAME"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="320" mass="35285" checksum="86B42990600FAE2D" modified="2017-01-18" version="1">MPTPTGEMLAPTTAPGGRTREPLQAAPARADLPEVGLPEVGLPEVGLPEVGLPEVDLPQGADLREMAPADARELTRVLLRRLSTLEEGTREYSYVRNTLVEMNLSLVRFAIRRFNSHREPKEDLLQVGAVGLVKAIDRFDPDLGVEFTTFAMPTVLGELRRHFRDTTWAVHVPRRLQELRIVLARAQEKLAHDLDRAPTPAELAEHLSLPVEEVVEGLTAANGHTAGSLDLGGAEDEDGPGPLADRLGEEDQRLSRVEDLVALKPLVAALPERERLILSMRFCEDMTQSQIGARLGLSQMHVSRLLSRTLRKLREGLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF83</accession>
    <name>A0A1E7NF83_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0001140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555996.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1516"/>
    <dbReference type="EnsemblBacteria" id="OEV39347">
        <property type="protein sequence ID" value="OEV39347"/>
        <property type="gene ID" value="HS99_0001140"/>
    </dbReference>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV39347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="439" mass="48414" checksum="1B6809543A60C430" modified="2017-01-18" version="1">MTVSIALFTQDLRLHDNPVLHAARDAADQVVPLFVLDPSVEAAGFAAPNRMAFLADCLVDLDAGLRGAGSRLIVRRGATAEQTARVAAETGAATVHVAAGVSAFARRREAALLALFGGRLHVHDASVTVVPAGRIAPAGRDHYAVFTPYHRVWQQAPHRTVLGAPRVIRTPDGIGSESLVATGPLSPALPRGGESAARERWRRWDLDGYAEGHDDLAGDSTSRLSPYLHFGCLSPTELVARALRHGGAGAEAFVRQLAWRDFHHQVLAARPDAAHRDYRTRNDPWHHDEREAEAWRQGRTGYPIVDAGMRQLAHEGWMHNRARLLTASFLAKSLYLDWRIGAAHFLTLLVDGDIANNQLNWQWVAGTGTDTRPNRVLNPLRQAERYDPDGNYVRRWLPELAHLPGRAVHRPWPLAPDYPDPLIDPDTLSARLRRARGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFK5</accession>
    <name>A0A1E7NFK5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0001765</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000108_gene3124"/>
    <dbReference type="EnsemblBacteria" id="OEV39452">
        <property type="protein sequence ID" value="OEV39452"/>
        <property type="gene ID" value="HS99_0001765"/>
    </dbReference>
    <dbReference type="OMA" id="ERENIGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="504" mass="51230" checksum="4B7DCDD7AC2EDC31" modified="2017-01-18" version="1">MTVAACAPAHGLTATEAARRLAEHGPNEVTADHRVPLWARIAAQLRDPLITVLLSAVALTLAIGDHPDAVVIALVIVVNTTVGVVQEVRAESAVAALSRLSAPAARVLRDGEHRKVPSAGIVPGDVVALAEGDIVPADARLVESAALLVDESMLTGESLPVTKAVEAAAPGDETVRAGTIVLRGRALAVVTATGAESALGRIAALLRPWPEPTPLQRRLAGLGRVLAAVAVGLCAVVFVLGLLRHQPPGEMGVTVISLAVAAVPESLPAVVTLALAMGARRMAARHAVVRRLPAVETLGSVSVLATDKTGTLTEGRMVVERLWTPHSTAVVTGLGYGPAGGIRLDGTADDEVKGLLTTAALCNDAALRPPTGGDGEWGALADPTEAALLTAAGKAGLDHERLRGRCGRARSFGSTCSPTASPASPWAPSRSPPAQWPGPRDRRASTSWAPGSGSGCCCSASSSRPPRSALLSGPAAAKAVGRACCSSPCWPPSSVSCWACANVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ4</accession>
    <name>A0A1E7NFZ4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS lactose transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HS99_0002860</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550335.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2766"/>
    <dbReference type="EnsemblBacteria" id="OEV39630">
        <property type="protein sequence ID" value="OEV39630"/>
        <property type="gene ID" value="HS99_0002860"/>
    </dbReference>
    <dbReference type="OMA" id="CKLMAPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="13">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="14">
        <location>
            <begin position="180"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="15">
        <location>
            <begin position="306"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OEV39630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="669" mass="67524" checksum="4C332039E4DBCD49" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG33</accession>
    <name>A0A1E7NG33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0003120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279332.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2819"/>
    <dbReference type="EnsemblBacteria" id="OEV39670">
        <property type="protein sequence ID" value="OEV39670"/>
        <property type="gene ID" value="HS99_0003120"/>
    </dbReference>
    <dbReference type="OMA" id="QAVIVPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="29304" checksum="087B1F1856EDBFAB" modified="2017-01-18" version="1">MRRRPNVLAGFGSLVWLVLVGLPLYVLLIATFRTRSDYSTGGPLKPPARWTLQNYLTDLSNGFGQDFLNTLTVTAGVVAIVLLVVPPLAYAIVRARGRATGWVFRLFLLGLAIPAQAVIVPMFYVISQTGLYDHLIGVILPTAAFCLPVCTLVLTGAMRDIGPELYEAMAMDGASPARVFRQLVLPLSRGGLSSITVFAALQAWNGFLFPLILTQSDSTKVITLGLYDFQTEHGVDVPGLLSAVVLSMLPVLIVYLFARRALVQGLTGVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGB7</accession>
    <name>A0A1E7NGB7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2886"/>
    <dbReference type="EnsemblBacteria" id="OEV39727">
        <property type="protein sequence ID" value="OEV39727"/>
        <property type="gene ID" value="HS99_0003455"/>
    </dbReference>
    <dbReference type="OMA" id="NIHRIWR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="257" mass="27792" checksum="61ED3B80B226024A" modified="2017-01-18" version="1">MAFLRAKQKAQVIEKLSQVAPPGETFIACVHAESGPSPWLAAALGEIPLVGLIIVLTRRYYFLTLTNSHVVINSANRWNNRPGDVVAAFPRHAFPVNRVKRASIWSSMYIQMPGNSSPTRLNIHRIWRAEMDQLSAAFPPGSIDPSSQPFDTPQGQGYPMPGQPMPGQPMPGQPGIPSQQGFGAPQGQPYPPQQPYPAAHAAPQGQPYPAPQAYPPAQPYPPQPGAQVPPQGQPYPPQVPNVPYPGQPGQQGYPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC4</accession>
    <name>A0A1E7NGC4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367073.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2920"/>
    <dbReference type="EnsemblBacteria" id="OEV39750">
        <property type="protein sequence ID" value="OEV39750"/>
        <property type="gene ID" value="HS99_0003615"/>
    </dbReference>
    <dbReference type="OMA" id="AMFTHYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="395"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="495" mass="51616" checksum="6693459B3FC77333" modified="2017-01-18" version="1">MADGQRLGAAFLAACARHGERRAVVAGSEELTYTRFADLVRDRADTLDALLGPDLANVGVHAANSIDHLVSYYALLVAGRLPFLIDATFGAAELDGIRTSCGVPAFLFGGKEPFPLGGDVRAVPDSALSLAVLPAPAGAPEPRASTATCRFTSGTTGAPKCLEFTADAVIAAADTWVAGTGLGPGDRVLCLAGFTNGLAFNTSLLPVFTVGAELHLYQGPPTSGGISRAVSRAAATRLVAFPLAYRLLAAAPRADVDAFATVTRAVSAAAVLDPEVRRGFESLYGVRIADYYGIAETGPCTYEREPDRSEGLGTALPGVSVRSVELPTGETEVRVRTASMAAGYLNAPGALAERLDADGYYRTGDLGHLVDGRLFVTGRLGGPINLAGRKIDPAEIERTLLALDGVTDAAVFADTDANGETVLHAALAGSGRIGRTEVVDACRARLAPFKVPGRVTFLPAIPRSTVGKARMTELRRLVQDVRAADDHPQELEEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGH2</accession>
    <name>A0A1E7NGH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0003775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279605.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2952"/>
    <dbReference type="EnsemblBacteria" id="OEV39777">
        <property type="protein sequence ID" value="OEV39777"/>
        <property type="gene ID" value="HS99_0003775"/>
    </dbReference>
    <dbReference type="OMA" id="GVDDNYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV39777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="21926" checksum="F79D38A6CBC24C65" modified="2017-01-18" version="1">MDYSGSDTVVGPASADLLPDTVTTAVKVVIVGGFGVGKTTLVGAVSEIRPLTTEETMTQAGVGVDDPTGVERKTSTTVAMDFGRISISDKLVLYVFGTPGQERFWFLWNGLFEGALGAVVLVDTRRLEVSFEVIGRLEDRGVPFVVAVNGFPEAPSYPLDELRQALDLPSEVPIVACDARSRESSRNTLMALMHYLYELAAPPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGV6</accession>
    <name>A0A1E7NGV6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0002920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386489.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000371.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2778"/>
    <dbReference type="EnsemblBacteria" id="OEV39855">
        <property type="protein sequence ID" value="OEV39855"/>
        <property type="gene ID" value="HS99_0002920"/>
    </dbReference>
    <dbReference type="OMA" id="CVAVDFR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV39855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="332" mass="35394" checksum="D9652E5DD2B81A6B" modified="2017-01-18" version="1">MADVAKLAGVSHQTVSRVLNGAPHVRPDTRDRVLAAIRELDYRPNSAARALVTRRSQTLGVVSFDSTLYGPASMLDGIERAARSAGYFVSVTSLRSLDGRSVQEAVDRLRDQGVEGVVVIAPQTSSVSAVARLSSSVPVVAVGSGDQNRVPMVSVANRSGAEEATGHLLDLGHRTVHHVAGPANWLESRDREEGWRLALQAAGAPVPEVERGDWSARSGYQAGLRIARLPEVTAVFCANDHMALGLLRALHEAGRSVPEGISVVGFDDIPEAAYFTPPLTTVRQDFAELGRRALEMLVGELEGVAFSGSRVEILPEMVLRRSVGPAPGAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV02</accession>
    <name>A0A1E7MV02_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279625.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000416.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2962"/>
    <dbReference type="EnsemblBacteria" id="OEV32259">
        <property type="protein sequence ID" value="OEV32259"/>
        <property type="gene ID" value="HS99_0016200"/>
    </dbReference>
    <dbReference type="OMA" id="DIPPMID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="95" mass="10367" checksum="52E71454E9EFD5E9" modified="2017-01-18" version="1">MTGDIGIEALGDHEYLVSFPTGGEAVFSRFQASEATLAQLSQARADEKRIVAETAAYLSERQQTADLPPMIDLDDVAAAYGDDYLEELGRRLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV17</accession>
    <name>A0A1E7MV17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279651.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000240.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2974"/>
    <dbReference type="EnsemblBacteria" id="OEV32268">
        <property type="protein sequence ID" value="OEV32268"/>
        <property type="gene ID" value="HS99_0016260"/>
    </dbReference>
    <dbReference type="OMA" id="CHRVGAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="14188" checksum="209B993DCE9D0C1B" modified="2017-01-18" version="1">MSLDVSPALLDQARNGRVDEADFLDTVRASLPYAYQVVAGLSTELAATEAEFTTDNTTPSDEQRAQLLRALASNAIRGSLEDHFGVKLAFVNCHRVGAFRPGSEDSKAYREFTSLHNQIRNQSPELRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVH6</accession>
    <name>A0A1E7MVH6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831548.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1178"/>
    <dbReference type="EnsemblBacteria" id="OEV32437">
        <property type="protein sequence ID" value="OEV32437"/>
        <property type="gene ID" value="HS99_0017280"/>
    </dbReference>
    <dbReference type="OMA" id="ENMARTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="436" mass="45076" checksum="29F21E90B356B07C" modified="2017-01-18" version="1">MSNLALYPVGLFFVLSAAHFARSRIDSRATARYTCYGTALLGAALLVLAPPTIRAVQSTGVAVLAVLAIVLGDGLRDGAAAAIRLLAPALRAADAAAHAAQAGNAEAAGNAARAVHRHEVRGGLALLGTVLGLRLALITAAAPGLSGEDLTVGPELSARLALAGYTAVGMLHTTVCLVALLRELVRRARAAGPGRLGTGLRLLTGGLVAGLLWNAWSMDDVLRAAATGIQDGPEDTLCAVLGGLCAALIAAGLGSTLWPAAAGAVRGWVHAHRRYRALTPLWRDLHTVLPQIALDPARRLPLPPRDPQFALYRRIIEIHDARLILRQHCDPRTAQWLDQATRRFPPPCDHAAATAEAAALAAALELAASGAVPEAAAPEAVLSAVPGTTVTDTMDGEAEHLAHLARVYATCPAVAEVRTRARAERARAASAAGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVP6</accession>
    <name>A0A1E7MVP6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037831233.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6868"/>
    <dbReference type="EnsemblBacteria" id="OEV32507">
        <property type="protein sequence ID" value="OEV32507"/>
        <property type="gene ID" value="HS99_0016405"/>
    </dbReference>
    <dbReference type="OMA" id="LAYAEPH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="319"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="484"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="702" mass="74535" checksum="80E542FD021914F1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT8</accession>
    <name>A0A1E7MVT8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000095">
        <property type="protein sequence ID" value="OEV32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289922.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene104"/>
    <dbReference type="EnsemblBacteria" id="ARF80102">
        <property type="protein sequence ID" value="ARF80102"/>
        <property type="gene ID" value="B6264_15305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32541">
        <property type="protein sequence ID" value="OEV32541"/>
        <property type="gene ID" value="HS99_0040225"/>
    </dbReference>
    <dbReference type="OMA" id="PLTWYDV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="149" mass="16217" checksum="2CFA069A0853654E" modified="2017-01-18" version="1">MDRADLSLGPLSEQDHAFYGLVWAGTTLAARVDRELARVHGLPLSWFEVMLWLNYQQEPVAASDLGAKTMLSRSQVSRVVDALAGRGLVSRTPSASDARSVRIELTGQGRALFAEADATRRAALAPVFTDRLDAADIAALEAVWRKLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWA3</accession>
    <name>A0A1E7MWA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290217.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000471.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7853"/>
    <dbReference type="EnsemblBacteria" id="ARF78244">
        <property type="protein sequence ID" value="ARF78244"/>
        <property type="gene ID" value="B6264_04320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32716">
        <property type="protein sequence ID" value="OEV32716"/>
        <property type="gene ID" value="HS99_0015765"/>
    </dbReference>
    <dbReference type="OMA" id="VCNCGYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="162" mass="18036" checksum="6E702E00A20DC87C" modified="2017-01-18" version="1">MRIREATPEDWPAIWPFFQTVVAAGETFPYPLDMPSELGREWWMHSAPDRTVVAVDEDGTVLGTANMNRNRPGNGGHVASASYLVDPAHHGKGIGRALVEYTLDWARRAGFRAMQFNAVVANNHHAVKLYRSLGFEIVGTVPEAFHHPVDGYVGLHVMHRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC6</accession>
    <name>A0A1E7MWC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285506.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7833"/>
    <dbReference type="EnsemblBacteria" id="ARF78224">
        <property type="protein sequence ID" value="ARF78224"/>
        <property type="gene ID" value="B6264_04210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32736">
        <property type="protein sequence ID" value="OEV32736"/>
        <property type="gene ID" value="HS99_0015875"/>
    </dbReference>
    <dbReference type="OMA" id="LWDNDGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="224" mass="23103" checksum="D48ED7C9D3CA104B" modified="2017-01-18" version="1">MPESVLPAAVLFDMDGTLVDTEQLWWQAAAELAEELDHPLTDRDAPEVLGQAVEHTAAHLHRASGTTRPEAELAARLGESFAGKVAAETVPRPGALALLAALREARVPTALVSASPRQVVDLVLSSIGRDWFAVTLAAEDTARTKPAPDPYLAAAERLGLDPAACVAVEDTPTGVASAAAAGCAVLAVPSTAVPMPDGDRITLLDSLERADLALLGKLCAAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR4</accession>
    <name>A0A1E7MWR4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000081">
        <property type="protein sequence ID" value="OEV32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557197.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000399.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene82"/>
    <dbReference type="EnsemblBacteria" id="ARF80122">
        <property type="protein sequence ID" value="ARF80122"/>
        <property type="gene ID" value="B6264_15415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32859">
        <property type="protein sequence ID" value="OEV32859"/>
        <property type="gene ID" value="HS99_0039730"/>
    </dbReference>
    <dbReference type="OMA" id="SEPHSWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="13102" checksum="FF0B8BFFD3416182" modified="2017-01-18" version="1">MSSVRRCSRTACGRPAVATLTYVYADSTAVLGPLATYAEPHCYDLCAEHAERLTAPRGWEVVRLASEAGPLRRSSDDLEALANAVREAARPQTPRQGRGPEGESTEGGRRGHLRVLRSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW3</accession>
    <name>A0A1E7MWW3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552585.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000663.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81330">
        <property type="protein sequence ID" value="ARF81330"/>
        <property type="gene ID" value="B6264_22645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32920">
        <property type="protein sequence ID" value="OEV32920"/>
        <property type="gene ID" value="HS99_0013630"/>
    </dbReference>
    <dbReference type="OMA" id="GVYALWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="132" mass="14541" checksum="7CBE4EFC021898F2" modified="2017-01-18" version="1">MSAVKFILNVIWLVFCGIWMALAYVLAGIICCVLIITIPFGIASFRIAGFILWPFGRTTVERRDAGAASCVGNVIWFVFAGWWLALGHLITSIPLFLSIIGIPFGWANLKMIPVSLMPLGREIVPTDQEWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX57</accession>
    <name>A0A1E7MX57_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0014195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043387591.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000420.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81436">
        <property type="protein sequence ID" value="ARF81436"/>
        <property type="gene ID" value="B6264_23225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33020">
        <property type="protein sequence ID" value="OEV33020"/>
        <property type="gene ID" value="HS99_0014195"/>
    </dbReference>
    <dbReference type="OMA" id="RVWAVDP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="25826" checksum="A0E0382381BEAF21" modified="2017-01-18" version="1">MNAAQHTHLAPVALVTGASRGLGLALAHALAGEGWQLVITARGAAELAEAETALAAVTKVVALPGSIVDDDHRAHLAEAAEGLGGASLLVNNAGSLNGAVTPGTEPLPRLADFPLPDLLELFEVNALAPIALTQLVLPQVRAHSGAVLNISSDTAVEAYPGWGGYGASKAALDLATAVLAREEPQVRVWAVDPGNMRTRMLQEASPGEDISGEPLPEEVAPVLIGLLRDRAPSGRYRAEDLAAAPVADRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX78</accession>
    <name>A0A1E7MX78_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Queuosine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279841.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000420.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5680"/>
    <dbReference type="EnsemblBacteria" id="ARF81437">
        <property type="protein sequence ID" value="ARF81437"/>
        <property type="gene ID" value="B6264_23230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33021">
        <property type="protein sequence ID" value="OEV33021"/>
        <property type="gene ID" value="HS99_0014200"/>
    </dbReference>
    <dbReference type="OMA" id="LSKHKMD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="38012" checksum="69BB9BA272BF6DB8" modified="2017-01-18" version="1">MTTLTELDLHVTVPPELSARAPAEARGGARDGVRMLVGRRATGAVEHRRFTELPEALRPGDLLVVNNSGTLPAALPGRLPDGTPVALHLSSAQPDQRGSHLVELRRPVPGSAASYYPPQESPARPGLHVALPAGGAAELVQPFTDRLWYAELSLPATLLPYLRLHGRAIRYGYVDRDWPIEAYQTVFASVPGSSEMPSAARPFTPTVVARLAGRGVLVAPVTLHTGVASPEAHEAPYAERFRVPATTARLVGHVRAGGGRVIAVGTTVVRALESAVGPDGTLQEADGWTELVITPERGVRGVDGLLTGWHEPRASHLLMLAAVAGRPLLTACYREAVRQRYLWHEFGDVNLLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA2</accession>
    <name>A0A1E7MXA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CbxX/CfqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0014315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5657"/>
    <dbReference type="EnsemblBacteria" id="OEV33041">
        <property type="protein sequence ID" value="OEV33041"/>
        <property type="gene ID" value="HS99_0014315"/>
    </dbReference>
    <dbReference type="OMA" id="TLNSWYW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="455"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="692" mass="74062" checksum="E0710322631C8601" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXK9</accession>
    <name>A0A1E7MXK9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0014630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000086_gene3435"/>
    <dbReference type="EnsemblBacteria" id="OEV33166">
        <property type="protein sequence ID" value="OEV33166"/>
        <property type="gene ID" value="HS99_0014630"/>
    </dbReference>
    <dbReference type="OMA" id="RMRFGQE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="272" mass="30422" checksum="6B948A8E85DD5589" modified="2017-01-18" version="1">MRRHVAPELAGVDSPRDVAPSDARELTRMLLRRLAALEEGTREYSYVRSTLIELNLSLVRYVIRRFDAQREPQEDLLQVGAVGLIKAIDRFDPDRDVEFSTFAIPTVLGEIRRHFRDTTWAVHVPRRLQELRIALAKAQDDLTTRLDRAPTVAELAGHLRLSEEEVIEGLTAANARTTGSLDFGSADDDESGSPLADRLGQEDAAIDLTENLVALKPLIARLSTREQLILSLRFTDELTQSQIGARLGLSQMHVSRLLTRTLKKLRDGLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXN2</accession>
    <name>A0A1E7MXN2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552481.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000645.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81409">
        <property type="protein sequence ID" value="ARF81409"/>
        <property type="gene ID" value="B6264_23080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32993">
        <property type="protein sequence ID" value="OEV32993"/>
        <property type="gene ID" value="HS99_0014050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="78" mass="8724" checksum="5D5019898FC1344F" modified="2017-01-18" version="1">MQTRGNDRRAVAVRLEAVEKTYGRGDNEVAALRNPSLAFGTGSFTLEALHWQEYFAALLNQTESTAEKRIKRSRGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXV5</accession>
    <name>A0A1E7MXV5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetate--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0039170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000071">
        <property type="protein sequence ID" value="OEV33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5917"/>
    <dbReference type="EnsemblBacteria" id="OEV33244">
        <property type="protein sequence ID" value="OEV33244"/>
        <property type="gene ID" value="HS99_0039170"/>
    </dbReference>
    <dbReference type="OMA" id="WYSSTGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="3">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="555"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="672" mass="72948" checksum="E2537DB0E1A75435" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY19</accession>
    <name>A0A1E7MY19_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0012060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33326">
        <property type="protein sequence ID" value="OEV33326"/>
        <property type="gene ID" value="HS99_0012060"/>
    </dbReference>
    <dbReference type="OMA" id="INASPQV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="33820" checksum="8BA2F43EDEC952A0" modified="2017-01-18" version="1">MDGMTVLEELPTAAGGRERRRTELARFLKACRARVTPEDVGLPPGLRRRTPGLRREEVAQLAGVGVTWYTWLEQGRPINASEQVLLAVSRALRLDGTERQHLFRLAGMAPSPLAQPAPPELSPSIQVILDSLAPLPAAVSNTRFDVLSFNRPYRSLFGTERMRPSHGVFFNSLWCMLTAPACCNPCENPEETLPRMVAVLRSAYGKHVGEPAWEDHVQRLSAGSELFRELWARQEVSPPHTLRRAFRHPELGVMRLNATYLTMPGVPECYIVVYVPENPEDRELVERLDSLTPGGWTHTCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY70</accession>
    <name>A0A1E7MY70_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553453.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4000"/>
    <dbReference type="EnsemblBacteria" id="ARF80493">
        <property type="protein sequence ID" value="ARF80493"/>
        <property type="gene ID" value="B6264_17660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33390">
        <property type="protein sequence ID" value="OEV33390"/>
        <property type="gene ID" value="HS99_0012435"/>
    </dbReference>
    <dbReference type="OMA" id="RLQICAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10892" checksum="CAD29C1B3678D804" modified="2017-01-18" version="1">MPTALDPLLQHATRLTVLAFLGACREAEFAAVRDHCEVSDSVLSKAATALEEAGYLVVKKGYVGKRPRTWLAATREGRAALAAHLAELQRLVAAAEAAGAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYS9</accession>
    <name>A0A1E7MYS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348951.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000258.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80495">
        <property type="protein sequence ID" value="ARF80495"/>
        <property type="gene ID" value="B6264_17675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33393">
        <property type="protein sequence ID" value="OEV33393"/>
        <property type="gene ID" value="HS99_0012450"/>
    </dbReference>
    <dbReference type="OMA" id="ELWKLWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="244" mass="25998" checksum="74C82F94BB774037" modified="2017-01-18" version="1">MPVPVILTGRTVRLEPLAAHHAEAIAEAGAEDRTTYAFTAVPHGLEAARDYVARALADQAAGRSMAFATVNVADGRVVGSTRFLELDYWQGPLVWPPTPGVPFGDPATAVPDAAEIGNTWLSPRAQGTGINTEAKLLMLRHAFETWGVQRISLRADARNLRSRAAIERLGATSEGVRRAHSRGLDGVVRSTAFYSILDSEWPAVRDIIELRIAAATSPSAPDPAINQECLRQGGSGAGQLMITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ27</accession>
    <name>A0A1E7MZ27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000062">
        <property type="protein sequence ID" value="OEV33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386795.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000505.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene4940"/>
    <dbReference type="EnsemblBacteria" id="ARF80008">
        <property type="protein sequence ID" value="ARF80008"/>
        <property type="gene ID" value="B6264_14795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33671">
        <property type="protein sequence ID" value="OEV33671"/>
        <property type="gene ID" value="HS99_0038465"/>
    </dbReference>
    <dbReference type="OMA" id="RQWPLLT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="141" mass="15198" checksum="39BB24BF95629B1F" modified="2017-01-18" version="1">MTEPRPARSRQRPVRTTGTLPPEGAAPALGRDHALPVRQWPITLVLSVVGAGLAVTWFADFKDGFKYGLLILGIGVLLGAVLRLVLPEVGMLAVRSRFTDVIVLAFLGASIVLLTLVAQPNPWLEIPLLDNIGQLIGRPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZE9</accession>
    <name>A0A1E7MZE9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0037650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4525"/>
    <dbReference type="EnsemblBacteria" id="ARF80383">
        <property type="protein sequence ID" value="ARF80383"/>
        <property type="gene ID" value="B6264_17025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33804">
        <property type="protein sequence ID" value="OEV33804"/>
        <property type="gene ID" value="HS99_0037650"/>
    </dbReference>
    <dbReference type="OMA" id="WPKVRRA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19348" checksum="D0646276493A7C8E" modified="2017-01-18" version="1">MIGKTRRAEESAEFEDFAYSRGQRLFRTALLLCGDWHLAEDLTQVTLAKLFAAWPKVRRADNQDAYARGTLVRSYLSHRRLRRSGERPALGELPEGTAPGDDPALRVTLLAALAELQPRDRAVLVLRYWEDRSVEETAAELGVSAGAVRAQSLRALGRLRAVLGPEAAEHLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZW6</accession>
    <name>A0A1E7MZW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386652.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000444.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2203"/>
    <dbReference type="EnsemblBacteria" id="ARF77832">
        <property type="protein sequence ID" value="ARF77832"/>
        <property type="gene ID" value="B6264_01830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33974">
        <property type="protein sequence ID" value="OEV33974"/>
        <property type="gene ID" value="HS99_0010985"/>
    </dbReference>
    <dbReference type="OMA" id="QFGHYLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22526" checksum="21C710029867A96E" modified="2017-01-18" version="1">MALEHAILVSLLEQPGSGYELARRFDRSIGRFWTATHQQIYRVLRRMEADGWVAAEEVAQDGRPDKKVYSAAGPGRAALAEWLREPVEPETVRHELAVKIRAAAFDDPAALTVLIAEVERHRESHSALLARYLHGEQRDFPDLGALDVQQELQHVVLRGGIEFERMNLAWLDDVLTTLRRLADGRGRGTGDREQTSGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N020</accession>
    <name>A0A1E7N020_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386037.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2272"/>
    <dbReference type="EnsemblBacteria" id="ARF77883">
        <property type="protein sequence ID" value="ARF77883"/>
        <property type="gene ID" value="B6264_02155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34026">
        <property type="protein sequence ID" value="OEV34026"/>
        <property type="gene ID" value="HS99_0011305"/>
    </dbReference>
    <dbReference type="OMA" id="HESQTEP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="271" mass="27960" checksum="A68869FCAAFE2CDD" modified="2017-01-18" version="1">MHFTSETSADGVSERRFVHDGVPGVLWHPAGSALGGRPLVLLGHGGGQHKLGSRDRAQACVARYGWAAVALDAPGHGERERTAQDERFATEIGELLAAGRPISAWVARHTAALAERAVPEWRAVLDTLDALEGPGRGPGPVGYWGLSLGTVIGIPLAAAEPRIRAAVFGLAGHASLLEPAGRVTVPVEFVLQWDDELSSREAALALYGALGSRQKTLHANPGGHRAVPEFELAASERFLLGHLGRTAAGTEAGATSPAGPGATPHAGPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N087</accession>
    <name>A0A1E7N087_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282154.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6391"/>
    <dbReference type="EnsemblBacteria" id="ARF78738">
        <property type="protein sequence ID" value="ARF78738"/>
        <property type="gene ID" value="B6264_07240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33883">
        <property type="protein sequence ID" value="OEV33883"/>
        <property type="gene ID" value="HS99_0037405"/>
    </dbReference>
    <dbReference type="OMA" id="IDRLATW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="60" mass="7294" checksum="6E16DFC7742DB399" modified="2017-01-18" version="1">MYFTDRGIEELESRRGEEEVSFEWLAERLREFVDLNPDFEIPVERLATWLARLDDEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0A8</accession>
    <name>A0A1E7N0A8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557289.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3720"/>
    <dbReference type="EnsemblBacteria" id="ARF77994">
        <property type="protein sequence ID" value="ARF77994"/>
        <property type="gene ID" value="B6264_02770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34130">
        <property type="protein sequence ID" value="OEV34130"/>
        <property type="gene ID" value="HS99_0011915"/>
    </dbReference>
    <dbReference type="OMA" id="SWAAVIH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16715" checksum="672901056CB8E2F4" modified="2017-01-18" version="1">MSRMTLGPVPVDTDYELEQLTQRMGIEIQTCEPGRVTGTMPVTGNRQPIGILHGGANAVLAETLGSLAALVHAGPGGSAVGVDLSCTHHRWVSSGTLTGECRPLYERQSVASYQIAITDDSGQRTCTALLTCVIRRGTARRRTGHSQDATRRTENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0B0</accession>
    <name>A0A1E7N0B0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="9" type="ORF">HS99_0011905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557286.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3718"/>
    <dbReference type="EnsemblBacteria" id="ARF77992">
        <property type="protein sequence ID" value="ARF77992"/>
        <property type="gene ID" value="B6264_02760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34128">
        <property type="protein sequence ID" value="OEV34128"/>
        <property type="gene ID" value="HS99_0011905"/>
    </dbReference>
    <dbReference type="OMA" id="LFGCPGW"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="333" mass="34331" checksum="A939911FB320044D" modified="2017-01-18" version="1">MTRAAVLAGVGATVPPRVVTNAELAQRLDTSDEWIRTRTGIAQRYVVDPGMTTGDLAVEAGQRALKSAGTTTVDLVVLATTTPDRLCPATAPSVATRIGLVGVPAFDVAAVCSGFLYALQAGAAAIAAGHADSVLVIGAETFSTILDPEDRSTRAIFGDGAGAVVLRAGQPDEPGAVRQIRLGSDGGMADLITVRGGGSEERTSGRPPRPEDAYFRMEGKSVFFTAVRRMTESSLEVLARTGWQVADVDRIVAHQANVRIVHAVADQLGVPTDRAVLNIDRVGNTSAASIPLALADGALDGRLTPGDRVLLTAFGGGATWGAATLTWPAVTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F8</accession>
    <name>A0A1E7N0F8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290600.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000100.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3707"/>
    <dbReference type="EnsemblBacteria" id="ARF82577">
        <property type="protein sequence ID" value="ARF82577"/>
        <property type="gene ID" value="B6264_02705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34178">
        <property type="protein sequence ID" value="OEV34178"/>
        <property type="gene ID" value="HS99_0011850"/>
    </dbReference>
    <dbReference type="OMA" id="FEMHGEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7902" checksum="C1EDE17567F0D259" modified="2017-01-18" version="1">MRIVVDLNRCQGYAQCAFLAPDVFEMHGEEALLYDPAFTEAHREQVRRAAAACPVQAILVEADEARVTPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0F9</accession>
    <name>A0A1E7N0F9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2227"/>
    <dbReference type="EnsemblBacteria" id="ARF82561">
        <property type="protein sequence ID" value="ARF82561"/>
        <property type="gene ID" value="B6264_01945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34164">
        <property type="protein sequence ID" value="OEV34164"/>
        <property type="gene ID" value="HS99_0011100"/>
    </dbReference>
    <dbReference type="OMA" id="FSWYGSR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="256" mass="27964" checksum="3D73A38461623652" modified="2017-01-18" version="1">MPVTLGPFPPRRVVSLVPSLTEAVAATAPGLLVGATNWCSHPADLAVARIGGTKNPDLPGVLALAPDLVIANDEENRRPDLDALRAAGVPVWVTDIRTLEDAFRSLDRLLTVACRLPRPAWLDRAEAAWRDVRPTADGPRTIVPIWRRPWMVLGRDTFAGDLLHRLGLRLVHADHPERYPTVPLPELLASRPELVVLPDEPYRFTAEDGPEAFPGIPVVLADGRHLTWYGPSLVTAPTVLRQAIDHPFTFGGETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0V6</accession>
    <name>A0A1E7N0V6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285296.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7638"/>
    <dbReference type="EnsemblBacteria" id="ARF78489">
        <property type="protein sequence ID" value="ARF78489"/>
        <property type="gene ID" value="B6264_05780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34301">
        <property type="protein sequence ID" value="OEV34301"/>
        <property type="gene ID" value="HS99_0036600"/>
    </dbReference>
    <dbReference type="OMA" id="WQSMKLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="23440" checksum="B6C447B9097E98F5" modified="2017-01-18" version="1">MGFLFEQDNFALFRDGFLQTIELSALSALLALLLGTLLAAFRVSPVPVLRAFGTTWVTLFRNTPLTLLFFAVTFGLPPLGVHFSHLTFAVLALGGYTASFVCEVIRSGINTVPLGQAEAARSLGMNFFQTLSLVILPQATRTVLGPMSSVFIALPRNSAIAGAFSVGELYSAQQTFSERGYSIFSIFFWVACAYLLISATVASLFRFLESRLAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W3</accession>
    <name>A0A1E7N0W3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551326.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6404"/>
    <dbReference type="EnsemblBacteria" id="ARF78729">
        <property type="protein sequence ID" value="ARF78729"/>
        <property type="gene ID" value="B6264_07175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34324">
        <property type="protein sequence ID" value="OEV34324"/>
        <property type="gene ID" value="HS99_0036360"/>
    </dbReference>
    <dbReference type="OMA" id="RMFVAWG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="412" mass="41596" checksum="189579BF49904FB3" modified="2017-01-18" version="1">MEHISFLVAVVIITALAFDFTNGFHDTANASATAIATGALRPKVAVTIAALLNFAGAFLSVKVATTISGGIVNEKAGVHPEIIFAALAGAILWNLLTWLRGLPSSSSHALYGGLIGATIVGVGMNGVNFDTVVTKIIIPAVASPFVAGLASWGATKLAYAITRKGGSAVSDKGFKTGQIFSSSLISLAHGTNDAQKTMGIITLTLVSVGALPHGALPPTWVIVSAGAAIALGTYMGGWRIIRSMGKGLADIKPLQGFASESAVSTVILTSSHMGFGLSTTQVCTGGIMGAGLGGPKPELRWSLVRRMVYTWGLTLPAAGLVSGGAAALARQGAWGVALVGAALVAGSAAMWVLSRRERVGADNVNDVAEVTPIEVTPIEVTPIDVVEVAPVEVTAAAPATAAPTPASTTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0X4</accession>
    <name>A0A1E7N0X4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-hydroxyhepta-2,4-diene-1,7-dioate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282109.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000588.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6418"/>
    <dbReference type="EnsemblBacteria" id="ARF78716">
        <property type="protein sequence ID" value="ARF78716"/>
        <property type="gene ID" value="B6264_07105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34336">
        <property type="protein sequence ID" value="OEV34336"/>
        <property type="gene ID" value="HS99_0036430"/>
    </dbReference>
    <dbReference type="OMA" id="PPEPIIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="283" mass="29830" checksum="6D82CD7CDF39FDE8" modified="2017-01-18" version="1">MKLLRVGPPGAERPVVLGEDGTAYDLSGRARDLDGAFLAGLDTAALAREVAAGVLPVVDLDGRRVAAPVARPGKVVGIGLNYRDHAAEAGAAIPAEPVIFLKPSSTVVGPYDEVLVPRGGEKTDYEAELAVVIGRTARYLDSHAEAAGVIAGYTIANDVTERAFQFERGGQWDKGKSAETFTPLGPWLVTADEVADPQALALRLWVNGEQRQNGNTAEMIFPVLELVRYASQFMVLEPGDVIITGTPAGVTLGRPGTPFLAPGDVVEIEIDGLGRQRQVLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N143</accession>
    <name>A0A1E7N143_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Autoregulator biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557292.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000064_gene3723"/>
    <dbReference type="EnsemblBacteria" id="ARF82579">
        <property type="protein sequence ID" value="ARF82579"/>
        <property type="gene ID" value="B6264_02785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34183">
        <property type="protein sequence ID" value="OEV34183"/>
        <property type="gene ID" value="HS99_0011930"/>
    </dbReference>
    <dbReference type="OMA" id="DHWYRSE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="310" mass="32335" checksum="47E552BF9B986FE8" modified="2017-01-18" version="1">MLTPVALTGATGFIGSAVLRVLTDGGARVRALARRVPEGDGRVDWVSGDLTDPGALARLCDGAEVVVHLASRVSGGAGECEAVNLRGTEALMAEAVRARAGRIIHLSTAAVYGEGPHSGIEVGGVPAAPVSEASRTRLLGERFALDAGGVVLRPGLVTGVGDRWVVPALGELVRRVPVRWGGGAARLSMVDRDDLARLIGALAIGEHAAPSGVHHASHPEPVRVGDLLAALARCGVLVAPRGPDLPWEECRRLLAANPGRLSERQFGLVARDHWYRSEEIWRVAGCPAGPGPLARIAAAAPWYREALSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N190</accession>
    <name>A0A1E7N190_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0036090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1400"/>
    <dbReference type="EnsemblBacteria" id="ARF79249">
        <property type="protein sequence ID" value="ARF79249"/>
        <property type="gene ID" value="B6264_10270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34431">
        <property type="protein sequence ID" value="OEV34431"/>
        <property type="gene ID" value="HS99_0036090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="289" mass="30781" checksum="08C0AC0DCE1A5579" modified="2017-01-18" version="1">MLNFFGLQIALVQADRDEISFHFGPHLTGISRDPDQLRVEFSRAPGKDAPGDFLVRRSDGTPLLRRTFRGWGNVPSAVPPFAALQDRFCLAQAVVLAKGGATVALLGGPYSEQANVGAALAQRSWEFVSGRLLVLDRRTGHVLPYLAPLEARGPAAAWLRGAGLPDGTWRSVTSPVGGEVLLVRPESLGPVVPVRARLAPPALVRLCRSVDEEVRLAPWEFTTRTWPAGSSGLLADAPTHCLHLPGVSGAEEAAGLIDHALTKEKDDPCLDVPAMPSAHRAGLTASLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1C0</accession>
    <name>A0A1E7N1C0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0035400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597005.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000260.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7060"/>
    <dbReference type="EnsemblBacteria" id="OEV34487">
        <property type="protein sequence ID" value="OEV34487"/>
        <property type="gene ID" value="HS99_0035400"/>
    </dbReference>
    <dbReference type="OMA" id="FAMYRFG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="36"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="419" mass="43656" checksum="2807DD5A65A7D800" modified="2017-01-18" version="1">MSTDTVRPEPAAQVQTVAEPAPARVTVWATFRDAPLAVKTVLAGVLVNRLSGFLNVFLVLFLGSKGYSEPETVLALGVYGGGAVLGVLVGGSLADRLGVRNATVASMGATAVLTAALLYLPGYGLLMAAVGLAGLSAQVFRPASATLLAELTPDDRQVMVFAMYRFGLNLGATAAPLVGFWLYHAGHDRYLLLFWGEALIALAYAVLALATLPAATRRSATAAAAPQAGGYRAVLRDRRYLRYLAAAFCHAVVYVQYLSTLPLFVQDRHLAIVWYTVAVSLNGVVVIAFELLVTRLAQSWPARITIGLGFALVGAGVACYALPIGAAAIVLGTLVWSIGEIIGGPTVFAYPGTAGPEQLKGRYIGSFQFVFGLGSALGPMLGGWLFIQAGVLVWPLLALGSLAATVLGLAAVRPSPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H4</accession>
    <name>A0A1E7N1H4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5577"/>
    <dbReference type="EnsemblBacteria" id="OEV34550">
        <property type="protein sequence ID" value="OEV34550"/>
        <property type="gene ID" value="HS99_0035255"/>
    </dbReference>
    <dbReference type="OMA" id="EMTESAH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18580" checksum="1C5C25DDB2B0B6DD" modified="2017-01-18" version="1">MTMSNDVSRAADKLAKLRAQADRLAGPMADAEAALVAAEEAEQARRAERAAEYDRTFLTTWTAQAAERSDRANELHAEFIELLSAEPWFQAYVAHRAERYKREKILTAAQNAQAHLGEARTLPEQRWYDLRIIEDITSAVDNAAAALGVAYAEELDAQRNAYIEAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1U2</accession>
    <name>A0A1E7N1U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0009060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000033_gene4262"/>
    <dbReference type="EnsemblBacteria" id="OEV34636">
        <property type="protein sequence ID" value="OEV34636"/>
        <property type="gene ID" value="HS99_0009060"/>
    </dbReference>
    <dbReference type="OMA" id="KLGDWEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="353" mass="37333" checksum="0F2C2F7EFFB89749" modified="2017-01-18" version="1">MARHRPTVRPRGPLITEEKPVDHRVFALDSLPLADGGTLPSAGIAYAVHGTLDADGRNAVLCPSYFGGDHTAYDWLIGEGRPLDTRRYCVVTVGLFGNGVSSSPSNHPLGVAFPRISPQDNVDAQYRLLTEELGVTELALVTGWSMGAAHAYQWAVSYPRMVRRIAPFCGSAATSEHNRVFLAALAAALRADGSADGGADRGRRAAGRVFAGWAASHPFWAQGGYRELGFASREEYLTGFWEEFFVAGPSTEDLLTMIDTWARADVGATPGFDGRTEAALGSVTAEAVLLPGARDLCFAVEDEARAAALMPRATLRVIPGVWGHLAGAGATAADREFIGAAITALLATQPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1V4</accession>
    <name>A0A1E7N1V4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000115_gene4543"/>
    <dbReference type="EnsemblBacteria" id="ARF81958">
        <property type="protein sequence ID" value="ARF81958"/>
        <property type="gene ID" value="B6264_26470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34678">
        <property type="protein sequence ID" value="OEV34678"/>
        <property type="gene ID" value="HS99_0009310"/>
    </dbReference>
    <dbReference type="OMA" id="WAWARIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="293" mass="31291" checksum="00C15D582016DA81" modified="2017-01-18" version="1">MRAALSLYPEWYRHERGEEITAVYDLVRRDGGRLLRLRELAGIAGHGLRVRTGLTSGGLAGQVLAQAVPFALGAGLGLRLSLSWLLQPWPSSQESGGEHAWQLALIAVWALAVLAAVAGRWGAARWIGAAAVALGLVEAVDSLLSGSLFALVGWASGPLLWLALLLMAPPDLLSGRPRRTLPMAVAGAMLSWLLLLGPDYLHTPLVWDPSWRPLQLLLAALLLLVANRRRLWPAGMVVGALPLLLTFTLPSVISYWEGPIGMLAAGGFAVVLPLLALRLIRAVRAKDEPPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1Z5</accession>
    <name>A0A1E7N1Z5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4655"/>
    <dbReference type="EnsemblBacteria" id="OEV34707">
        <property type="protein sequence ID" value="OEV34707"/>
        <property type="gene ID" value="HS99_0009465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="94" mass="9963" checksum="1D9558ADE5EBC256" modified="2017-01-18" version="1">MSNSASVNAQVNGRAPLVRLYLVRGVLAAVWAVAFAHAHDTLGAAAITLLVTYPLLDAVSSAVDYLSVPDGPEQRVQAGLLVWKVRRGVAQLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N201</accession>
    <name>A0A1E7N201_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389150.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4629"/>
    <dbReference type="EnsemblBacteria" id="ARF81908">
        <property type="protein sequence ID" value="ARF81908"/>
        <property type="gene ID" value="B6264_26175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34730">
        <property type="protein sequence ID" value="OEV34730"/>
        <property type="gene ID" value="HS99_0009600"/>
    </dbReference>
    <dbReference type="OMA" id="DDPVPSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="231" mass="24903" checksum="42D685AF59B4DD54" modified="2017-01-18" version="1">MHRQAVEVIGEQIVRGTYAPGDSLHPDRIEQELGVSKTVVREALRVLASKGLIDSRQKRGTFVRPRADWNLLDSDLLRWQGRGIPDETFLDNLGEVRGIVEPAGARLAAERRDEADLAALEDALDQMAAAGSDAHAAVEADLAFHRALLAAAHNELLTRMEVVIEAGLRVRDHIVHGADHSADAVPAHRAVLDAVRAQDAEAAARAVEELLAQAAADLHQLTVDADRGDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2E7</accession>
    <name>A0A1E7N2E7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease BN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0010380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385939.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7595"/>
    <dbReference type="EnsemblBacteria" id="ARF81777">
        <property type="protein sequence ID" value="ARF81777"/>
        <property type="gene ID" value="B6264_25340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34861">
        <property type="protein sequence ID" value="OEV34861"/>
        <property type="gene ID" value="HS99_0010380"/>
    </dbReference>
    <dbReference type="OMA" id="KQPKFRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="36539" checksum="171D4408C25033C6" modified="2017-01-18" version="1">MGWFRRAHGEHDGGPVRGPQEATDQGPDAPTQVPGRGWLGVLRRTWREFLDDELSDRAAALTYYGVLATFPALLVLVSVLGLLGTSATHAVLDNLQQLAPGPARDILHTAVTQLQASRGTGGVLAVVGLAGSLWSASGYIAAFIRAGNVVYDIREGRPMWKTTPLRVGLTLLMMILLTASAVIVVFTGPLAQRAGDVIGLGHTAVTVWSIAKWPVLVALVSLMIAVLYWAAPNVRGRGFRWVSPGSVLAVLLWLLLSGGFAAYVANFGSYNKTYGTLAGVIVFLVWLWLSNLAILLGLEFDAELARERAIEGGMPPGEEPYVPPRDTRTWPDDEHGDGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2L2</accession>
    <name>A0A1E7N2L2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554104.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000879.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5872"/>
    <dbReference type="EnsemblBacteria" id="ARF77541">
        <property type="protein sequence ID" value="ARF77541"/>
        <property type="gene ID" value="B6264_00115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34916">
        <property type="protein sequence ID" value="OEV34916"/>
        <property type="gene ID" value="HS99_0034975"/>
    </dbReference>
    <dbReference type="OMA" id="TDMIEVG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="831" mass="86435" checksum="D1F85EE57C40FF9A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2R4</accession>
    <name>A0A1E7N2R4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287984.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7675"/>
    <dbReference type="EnsemblBacteria" id="ARF78540">
        <property type="protein sequence ID" value="ARF78540"/>
        <property type="gene ID" value="B6264_06105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34960">
        <property type="protein sequence ID" value="OEV34960"/>
        <property type="gene ID" value="HS99_0034655"/>
    </dbReference>
    <dbReference type="OMA" id="VCDCGRN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20328" checksum="3FD08EE12A69768B" modified="2017-01-18" version="1">MSTTQPLVLAAELAAAWSDIQAHHQDLPDLASPEALIGESSSACGTRLGFERLLHEAAHGLAAARDIRDTSRAGRYHNRRFLMLASELGLAHPVEPHASSGFSQVTMLKETQERYAETIERLDRALGAHQEAVAGDGTNRAFRGPAARHGSSGGGVRVKAVCGCGRNVRVVPSVLAQASIVCGACQQPFKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N305</accession>
    <name>A0A1E7N305_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367094.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4738"/>
    <dbReference type="EnsemblBacteria" id="OEV35067">
        <property type="protein sequence ID" value="OEV35067"/>
        <property type="gene ID" value="HS99_0034570"/>
    </dbReference>
    <dbReference type="OMA" id="DPWVAWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="16060" checksum="AEFB4549E799344B" modified="2017-01-18" version="1">MGLMAGLFFAFDVSVMPGLAAGDDRTYVTAMRHINKSIENGMFGLVFVGAFLATGVAAWLQHKAGRRRAALWAGAATLLYVVALMVTMGVNIPLNNELAAAGDPARIHDLAAMRAKFEGAWVATNMLRTALCTAGLLALTRSLVLHGRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N383</accession>
    <name>A0A1E7N383_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucrase ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285431.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000209.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4461"/>
    <dbReference type="EnsemblBacteria" id="ARF78439">
        <property type="protein sequence ID" value="ARF78439"/>
        <property type="gene ID" value="B6264_05455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35158">
        <property type="protein sequence ID" value="OEV35158"/>
        <property type="gene ID" value="HS99_0033800"/>
    </dbReference>
    <dbReference type="OMA" id="RDRCCAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010350">
        <property type="entry name" value="Aim32/Apd1-like_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030108">
        <property type="entry name" value="Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="PTHR31902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF10">
        <property type="entry name" value="PTHR31902:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035042">
        <property type="entry name" value="UCP035042_thirdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="31508" checksum="8F5BBE04C9A9E277" modified="2017-01-18" version="1">MSTCTTVSCELAEPLAATAAVATTWLLVEQNGPWGAKALGESHLDRATGRALEAAAAGTGVRVALIRRPGRHADCPPTTRHGVVVAHTVPGRGWVRRAQVVDPAELLELDFAALGAGDHTGFGAEHVGGPMALVCTNGRRDRCCALLGRPLAAELAAAGHSEVWEVTHLGGHRFAPTMLVLPYGYAYGRLTPESAKDVLAATAAGHMVPEWSRGCSGWERPGQAAEHAVRLATGETGADALTVAQRPDGEGRWLVRVVHRDGRAWEVDVIETVSEPPRPESCGKAAGTPSRMDVLSVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N391</accession>
    <name>A0A1E7N391_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285425.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000209.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4458"/>
    <dbReference type="EnsemblBacteria" id="ARF78442">
        <property type="protein sequence ID" value="ARF78442"/>
        <property type="gene ID" value="B6264_05470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35156">
        <property type="protein sequence ID" value="OEV35156"/>
        <property type="gene ID" value="HS99_0033785"/>
    </dbReference>
    <dbReference type="OMA" id="RTVMHEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="29718" checksum="794E0EFFD59FD622" modified="2017-01-18" version="1">MSTPAIELTGATKRFRTPSGALHTAVRDLDLTVAQGEFVAVVGPTGCGKSTTLTLVSGLEEPTEGEVRVYGEPVRGIDPQVGFVFQQDAVFPWRTVLSNVMAGPRFRGVPAAEAKERARDWLGRVGLAAFEDRYPHQLSGGMRKRVALAQTFVNDPAILLMDEPFSALDVQTRALMSDQLLELWAGTSSSENAASVVFVTHDLDEAIALADRVVVMTAGPATVKEIFTVDLPRPRTVEAVRLEPRFVELYREIWASLGEEVRITRERGAGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E8</accession>
    <name>A0A1E7N3E8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289804.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1395"/>
    <dbReference type="EnsemblBacteria" id="ARF79254">
        <property type="protein sequence ID" value="ARF79254"/>
        <property type="gene ID" value="B6264_10295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35195">
        <property type="protein sequence ID" value="OEV35195"/>
        <property type="gene ID" value="HS99_0033265"/>
    </dbReference>
    <dbReference type="OMA" id="PLYATVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28524" checksum="134DB0FE2B215EC6" modified="2017-01-18" version="1">MKFRFKALQRMREPDELDSPTLLAAPRGWIALFVVMITMATALLWTFAGNIPITVDAPGLLTHPHGTAMIQSPFGGMVRTVLAKPADQVRQGQSVVRVEDTEGHSREITSPFGGRVVGLSVTDGQVVAPGSPVASVERVDDPQERVVAMVFVPATRSVGLEPGDQVDLNVSTTPAGTFGLLRGTVSSVSPYALTREAVSGLVGGDLAAQRYLGKDAPRLVVVDLTPDPDTPSGFAWTSQSGPPHPLGTQVAVTATINVGRQTPFNLILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3K6</accession>
    <name>A0A1E7N3K6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386417.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000355.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5276"/>
    <dbReference type="EnsemblBacteria" id="ARF80692">
        <property type="protein sequence ID" value="ARF80692"/>
        <property type="gene ID" value="B6264_18855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35266">
        <property type="protein sequence ID" value="OEV35266"/>
        <property type="gene ID" value="HS99_0032915"/>
    </dbReference>
    <dbReference type="OMA" id="GPSKLHM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="17071" checksum="3E1446479C2F761C" modified="2017-01-18" version="1">MSSSRAHEVIGADLDETDRQLLARLGSDGRASYAEIGLQVNLSATAVRRRIDRLRARGVVRGFTVVLDPAVLGWQTEAFVEVYCRERTAPEEILASLRQFPEVVAAWTVTGDPDALVHLRAADMRHLEAVIERIRREPGVQRSRSSVVLSQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4C3</accession>
    <name>A0A1E7N4C3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552726.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5478"/>
    <dbReference type="EnsemblBacteria" id="ARF79424">
        <property type="protein sequence ID" value="ARF79424"/>
        <property type="gene ID" value="B6264_11270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35535">
        <property type="protein sequence ID" value="OEV35535"/>
        <property type="gene ID" value="HS99_0032080"/>
    </dbReference>
    <dbReference type="OMA" id="AERYWRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="32165" checksum="4F6A75BC8A32A0BE" modified="2017-01-18" version="1">MTTTGTPYHSGERTAQARAGVTDRADHAGRSIRSTVPAVAARFLTERRMLVVGAADPDGRIWATQLSGPAGFLQAADERTMTVAARPAGADPLAEALARPAQIGTIALDPAGRRRMRLNGRSAPDGRGGLTVHAEEVVSNCPKYIQRRTPLDRPGAGSPRTVSEGPALSTAQRLAVNTSDTFFIATAGPDGRVDASHRGGFPGFLQAVAPDTVRWPEYRGNAMFMTLGNLELDPRAGLLLPDWETGGALLITGEARTDWSEEARQAAPGAERMVELTVTGVRELADATPLTWTDPEYSPANPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4S4</accession>
    <name>A0A1E7N4S4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281791.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000497.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene925"/>
    <dbReference type="EnsemblBacteria" id="ARF80847">
        <property type="protein sequence ID" value="ARF80847"/>
        <property type="gene ID" value="B6264_19775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35654">
        <property type="protein sequence ID" value="OEV35654"/>
        <property type="gene ID" value="HS99_0007005"/>
    </dbReference>
    <dbReference type="OMA" id="YERTHRF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="281" mass="30622" checksum="96BCFB6CDD0E1BD9" modified="2017-01-18" version="1">MSASSSVQQARQALGQRLRDIRRDSGLSARALAEAAGWHESKCSKIQSGRVMPSEADIRTWTAICGAPGQAADLIATARNIEGMYIEWLRLERSGLKRAQESVRPLFQRTRRFRMYQSWVVPGLLQTPAYTRAVLNTIVSLRSAPDDVDDAVAVRIERQKVLHSGDHRFAILVEEWVLRTVIGTPDVLIGQLGHLSTVSALPSVSLGVIPLGSPRGSGWPVESFTMYDDAQVNVELVSAHLTITQPAEIAEYSRTFSELAGIAVHGAEARSLITSAINALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U2</accession>
    <name>A0A1E7N4U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551139.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000618.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene900"/>
    <dbReference type="EnsemblBacteria" id="ARF80871">
        <property type="protein sequence ID" value="ARF80871"/>
        <property type="gene ID" value="B6264_19900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35674">
        <property type="protein sequence ID" value="OEV35674"/>
        <property type="gene ID" value="HS99_0007130"/>
    </dbReference>
    <dbReference type="OMA" id="SEHEYAM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="36"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="297" mass="32571" checksum="201EEFA3AE580039" modified="2017-01-18" version="1">MIPFDEDRARLLLAHACESAGLPAPGDARLLALGENAVFDLGDPAVVAKVGRGPELYDRAHRELTVAHWLAGQDVPVVRPYEAVVPEPQSADGHPVTFWHRLAPAVRPARPADLAPLLRALHRLPLPPFPLGRRDLLAPVERWLASAEGHVDPADVAFLRHRRDAFEAALPDLVPRLHPGVIHGDALPRNVHVGPDGPVLLDLENVSRDLREHDLVVLALSHDRYGVPGEEYRAFTEAYGWDVRDWPGFAVLRGARETASASWVAQQAAGNPAALAEFGRRVASLREGATEVRWYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N575</accession>
    <name>A0A1E7N575_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366830.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000419.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene985"/>
    <dbReference type="EnsemblBacteria" id="ARF80796">
        <property type="protein sequence ID" value="ARF80796"/>
        <property type="gene ID" value="B6264_19470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35603">
        <property type="protein sequence ID" value="OEV35603"/>
        <property type="gene ID" value="HS99_0006700"/>
    </dbReference>
    <dbReference type="OMA" id="DRIAMAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="16278" checksum="77709AF02625B008" modified="2017-01-18" version="1">MAEVPYDELRWEVVLAAAVRIRDELAGRGRVLSQVLVDFPAAHGPLAPDLTVIAPDAVHHARGRYAASDVEAVLEVSHPGRDHAWARACAESGVPLYVVVDPAAAVCTVHTAPSPGGVYREAERVPFGNDLFLPLGGRTVVLRTDEFPTPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5A5</accession>
    <name>A0A1E7N5A5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366833.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene947"/>
    <dbReference type="EnsemblBacteria" id="ARF80827">
        <property type="protein sequence ID" value="ARF80827"/>
        <property type="gene ID" value="B6264_19665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35633">
        <property type="protein sequence ID" value="OEV35633"/>
        <property type="gene ID" value="HS99_0006895"/>
    </dbReference>
    <dbReference type="OMA" id="VWCPEGL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="32010" checksum="67B743492821D0EA" modified="2017-01-18" version="1">MGIVTVATTPQSPLHDLDSSVDEDDTGDDAVRRSAGVGESSRASRHWWDRNADEYQDEHGEFLGDDRFTWCPEGLDEADARLLGDVSGRDVLEIGAGAAQCSRWLAARGARPVALDISYRQLQHSRRIDLGRGTAPVPVVQADAAVLPFADASFDLACSAYGAVPFSADTERLMREVHRVLRPGGRWVFSVTHPIRWAFPDEPGVEGLTATSSYFDRTPYVEQDENGNATYVEHHRTLGDRVRELVAAGFRLIDLVEPEWPADLEQEWGGWSPLRGRLIPGTAIFVTERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F7</accession>
    <name>A0A1E7N5F7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551120.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000646.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene875"/>
    <dbReference type="EnsemblBacteria" id="ARF80895">
        <property type="protein sequence ID" value="ARF80895"/>
        <property type="gene ID" value="B6264_20030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35693">
        <property type="protein sequence ID" value="OEV35693"/>
        <property type="gene ID" value="HS99_0007255"/>
    </dbReference>
    <dbReference type="OMA" id="SNAVCRK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="169" mass="18495" checksum="C4F8758BA6FDFF20" modified="2017-01-18" version="1">MTEIAVRIEPWTDADLALLRRVNTPEMKKHVGGPETEEQLLVRHGRYLDFVPSGLGCMYRIVLLPGGEAVGTVGYGTRTWAGGTVHEMGWNVLPGHQGKGIAVTATRAAVAAARREAAHRFLHAFPSVDNPASNAVCAKAGFTLLGETEFEFPPGRFMRSNNWRVDLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5H6</accession>
    <name>A0A1E7N5H6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0006425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282880.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5343"/>
    <dbReference type="EnsemblBacteria" id="OEV35928">
        <property type="protein sequence ID" value="OEV35928"/>
        <property type="gene ID" value="HS99_0006425"/>
    </dbReference>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="107"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="341"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="681" mass="71702" checksum="048514E2A7894E3F" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U2</accession>
    <name>A0A1E7N5U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551264.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6346"/>
    <dbReference type="EnsemblBacteria" id="ARF78777">
        <property type="protein sequence ID" value="ARF78777"/>
        <property type="gene ID" value="B6264_07465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36055">
        <property type="protein sequence ID" value="OEV36055"/>
        <property type="gene ID" value="HS99_0031660"/>
    </dbReference>
    <dbReference type="OMA" id="WTAHPIT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9942" checksum="236590E0D9022DC5" modified="2017-01-18" version="1">MSAVRAGISGIMLPTVFPSLDHALPVLWDHVRRRPVRAAHRDFIRLCIGPGGGDGVAECLSRGGRWSVTLYIGDMTDWTAHPITITTRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5U5</accession>
    <name>A0A1E7N5U5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282266.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000980.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6336"/>
    <dbReference type="EnsemblBacteria" id="ARF78786">
        <property type="protein sequence ID" value="ARF78786"/>
        <property type="gene ID" value="B6264_07515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36049">
        <property type="protein sequence ID" value="OEV36049"/>
        <property type="gene ID" value="HS99_0031610"/>
    </dbReference>
    <dbReference type="OMA" id="MIRNAYG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="240" mass="25412" checksum="6A64A0613FC37B68" modified="2017-01-18" version="1">MNPNNQNLGELWDRVTGTQAAPPGWLVLATGCAALLTVLARPLWHVARNAVTIAHEGGHGLAALVTGRKLAGIRLHSDTSGLTLSYGRPTGPGMVLTAAAGYTAPALLGLGCAALLAADRITLLLWLAIALLLALLIRIRNAFGLFTVLIAGGAFFLVSWFGSAQVQAGFAYLGCWFLLFGAVRPVLELQHQRRIGWARDSDADQLARLTHVPALAWVTVFLLIALACLALGASWLLQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V2</accession>
    <name>A0A1E7N5V2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6351"/>
    <dbReference type="EnsemblBacteria" id="ARF78773">
        <property type="protein sequence ID" value="ARF78773"/>
        <property type="gene ID" value="B6264_07440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36058">
        <property type="protein sequence ID" value="OEV36058"/>
        <property type="gene ID" value="HS99_0031685"/>
    </dbReference>
    <dbReference type="OMA" id="QSQWDPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="335" mass="34002" checksum="64A0B4B1B8E3F82B" modified="2017-01-18" version="1">MPPPSGGFGPPPASYGPVAPSSQPLPQPVPPVPQPQPVAQPQPQQPVQPMPPQPQWQQQPPQQAVPPRRVEPDWQALADRNEAAGKRKRRMQVIGIVAAVVLVGGGVAGGMLLLGKKDDPKKSGPVTASTASDKPTPGPTSASSSPGGQTDDPSKPIWEAATDPAPQDAGALFSAMQVTVNGATWNRTVVSLDQPCWDGNSTTGGLGKVLGDQGCQKVLRATYVSGDSAVTVGVAVFDHKIQAETATKNYSGQLKGLPAPGAPAFCANPGCTSTHSSLGRYAYFTVEGSAKGGNAPDATATAAASGFAEHVKGQLLRRAKAAGSATPGSQGTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5Y1</accession>
    <name>A0A1E7N5Y1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7241"/>
    <dbReference type="EnsemblBacteria" id="ARF81076">
        <property type="protein sequence ID" value="ARF81076"/>
        <property type="gene ID" value="B6264_21135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35863">
        <property type="protein sequence ID" value="OEV35863"/>
        <property type="gene ID" value="HS99_0008355"/>
    </dbReference>
    <dbReference type="OMA" id="QAIKLSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="31926" checksum="E0C5912F66138148" modified="2017-01-18" version="1">MSITPHDTNRPWRGVMVATTIPLRPDHSVDYDAYAEHVRWLIESGCHGVVPNGSLGEYQTLTAEERARIVEVAVEAAGDGSRVMPGVAAYGSAESRRWAEQAAEAGAGSVLLLPPNAYRADHASVRAHYAEVARAGLPVVAYNNPIDTKVDLVPALLAQLHGEGSIVAVKEFSGDVRRAYELAELAPGLDLLIGADDVLLELALAGAVGWIAGYPNALPDACVALYDAAVGHDLGAALPLYKSLHSLLRWDSKTEFVQAIKLSMDIAGRPGGPVRAPRLPLEPEIEAAVRAATEKALAEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N615</accession>
    <name>A0A1E7N615_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="10" type="ORF">HS99_0031170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281056.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5010"/>
    <dbReference type="EnsemblBacteria" id="ARF80076">
        <property type="protein sequence ID" value="ARF80076"/>
        <property type="gene ID" value="B6264_15150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36130">
        <property type="protein sequence ID" value="OEV36130"/>
        <property type="gene ID" value="HS99_0031170"/>
    </dbReference>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="273"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV36130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="556" mass="59989" checksum="5032E23FD99F5475" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6I7</accession>
    <name>A0A1E7N6I7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0030310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386022.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2615"/>
    <dbReference type="EnsemblBacteria" id="OEV36302">
        <property type="protein sequence ID" value="OEV36302"/>
        <property type="gene ID" value="HS99_0030310"/>
    </dbReference>
    <dbReference type="OMA" id="EHMNYPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1410"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="2027" mass="216779" checksum="8BA8C7AB9A5A6817" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T3</accession>
    <name>A0A1E7N6T3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000069_gene7170"/>
    <dbReference type="EnsemblBacteria" id="ARF82354">
        <property type="protein sequence ID" value="ARF82354"/>
        <property type="gene ID" value="B6264_28865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36354">
        <property type="protein sequence ID" value="OEV36354"/>
        <property type="gene ID" value="HS99_0029790"/>
    </dbReference>
    <dbReference type="OMA" id="RITLMWC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="21320" checksum="6908E58C2887DB92" modified="2017-01-18" version="1">MGKQYESIDGRLRQFIERQPVYFVATAPLAGDGHVNLSPKGRSGTLAIIDELTLAYLDFGGSQAETVAHLRENGRITLMWCAFDGPPTVVRVHGRGEPVFRDDPRFAELLGRFEPGADGAGLRAIVVVRAERVSDSCGYAVPFMDYRGDRDLHAQYFDRKGEEQFSAYCEGKPLVRTSIDGLPALPLPVPARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Z4</accession>
    <name>A0A1E7N6Z4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7724"/>
    <dbReference type="EnsemblBacteria" id="OEV36414">
        <property type="protein sequence ID" value="OEV36414"/>
        <property type="gene ID" value="HS99_0029900"/>
    </dbReference>
    <dbReference type="OMA" id="EYGIAMW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="49942" checksum="3425EAE270875EFE" modified="2017-01-18" version="1">MAGYRAGAFLGAGAWGSVYAAEGPDGTPAAVKLLGPARSSPGQRRTLAQMAARELRFSSRADHPHLIRTLAVVTVDDPDRPELDGAVALVMERAAHSLQDVLAAARAGTAVPGAERILTEVCAGLTHMHRAGWVHGDLKPANILLMPDGTAKIADFGLTAELEGTHAYAPPLGSPDHVPPEWWSQRTGARGVALRPSADVWAFGVIAHQLFTGGLHPFLGATARARSLAAQAYARGAAPLRLDQALPTRWRPVVAACLAADREERARTDLAALVARATARPAGRRRAVRAGAGVLACAAVLLVLTGGPEPRAPGVHRAVPPLPGAIPAGSDVPVAYRGMIEDAARRCPEPEITPVLLAAMLKAESGFDPNAARPETGEYGIAMWTPAVFEAWSKAANHDGPKSYLDPGDAIAAMGNYVCWLDQQIRHRGFTRDLPALVAAAYRTSDKSVAAAGGVPERVRPHVDKVLRYLADYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7G0</accession>
    <name>A0A1E7N7G0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PASTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0028130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278944.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000161.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2542"/>
    <dbReference type="EnsemblBacteria" id="OEV36642">
        <property type="protein sequence ID" value="OEV36642"/>
        <property type="gene ID" value="HS99_0028130"/>
    </dbReference>
    <dbReference type="OMA" id="CTIMRHT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="205" mass="20665" checksum="0A60380028C6D04A" modified="2017-01-18" version="1">MTPFPPDDQTGHHGPMPGPDFREALIQAMDDFANDAHPPAFDGTAILHRTRRRRGLVAVTASAAAIVLTAGTAFALHDSGRPTGRNAAASGVSATASAVPNTPSPVPGTTATASPGVPMGSGTPSPSAHSEPGPGDASVTVPAVLGMTQDRAEKILTEAGLKIGRVQDFTDWNTPAGAVINTEPRPGAAVAPDSAVVLFVSKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7J4</accession>
    <name>A0A1E7N7J4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">HS99_0028255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037828210.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000737.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2516"/>
    <dbReference type="EnsemblBacteria" id="ARF81488">
        <property type="protein sequence ID" value="ARF81488"/>
        <property type="gene ID" value="B6264_23540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36661">
        <property type="protein sequence ID" value="OEV36661"/>
        <property type="gene ID" value="HS99_0028255"/>
    </dbReference>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="252" mass="25447" checksum="ECC95FA5818BEBE3" modified="2017-01-18" version="1">MSARILFVTGTNTDVGKTVATAAVAAAALRAGRKVAVLKPGQTGVAPGEPGDAAEVARLAGDLTISELARYPEPLAPDTAARRSGLPYLSPAEVVAEVADLAATHDVVLVEGAGGLLVRYDDQGRTLADQARAVLDAGLPAEVLLVASAGLGTLNIVALTAEALAARGLPLAGVLVGSWPTDPGLAERCNLADLPRSAGAPLLGALPERAGAAEDFTEVALASLAPELGGTWDAEHFAHVHRPEPGPRPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7S7</accession>
    <name>A0A1E7N7S7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284683.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000482.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4782"/>
    <dbReference type="EnsemblBacteria" id="OEV36756">
        <property type="protein sequence ID" value="OEV36756"/>
        <property type="gene ID" value="HS99_0027465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198849" evidence="1">
        <location>
            <begin position="32"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="380" mass="40227" checksum="1B6AB84CD409FB5A" modified="2017-01-18" version="1">MTASRARAATVSGCLVLLAVGLGACGHTPPAAPKDPSVATSARDVGGMDALTAAAKKEGTLRAIAIPRDWADYGGLIDGFEKKYGITVTVDDPLGHSQDEIDAIKKNGKQQSAPDVIDVGDTFARAAGPQNLLAPYKVAAYSSIPSNQKDPHARWSNNYGGYISIGCDANRVEICPQTFADLLKPAYQGKVALEGDPTRSETGFASVYAAALANGGSFDNIQPGLDFFAKLKQAGNLNPVGATSVTVASGQTPISINWDFVNLNYTDQLRSKGVNWQVSIPFDGSFAQYYALAINKDAPHPAAARLWQEYLFSTEGQNLRLNGYARPVLLDVMKKDGTLDEAAFARLPTVEGTPEFPTDAQTEKAKETVALGWAKAVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N889</accession>
    <name>A0A1E7N889_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="9" type="ORF">HS99_0026725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282045.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6446"/>
    <dbReference type="EnsemblBacteria" id="ARF78690">
        <property type="protein sequence ID" value="ARF78690"/>
        <property type="gene ID" value="B6264_06960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36864">
        <property type="protein sequence ID" value="OEV36864"/>
        <property type="gene ID" value="HS99_0026725"/>
    </dbReference>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="127" mass="13304" checksum="BBA6E7F122F259F3" modified="2017-01-18" version="1">MAELHVELVAADRKVWSGAATIVVARTASGDTGIMPGHTPVLSVLETGPVTIRTVDGGTVIAAVHGGFISFADNKLSLLAEIAELADEIDVARAERALEQAKSDLDAHAERRAEVRLFAARGLKAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C1</accession>
    <name>A0A1E7N8C1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA ligase</fullName>
            <ecNumber evidence="9">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ligA</name>
        <name evidence="11" type="ORF">HS99_0027205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286985.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6810"/>
    <dbReference type="EnsemblBacteria" id="ARF78605">
        <property type="protein sequence ID" value="ARF78605"/>
        <property type="gene ID" value="B6264_06490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36946">
        <property type="protein sequence ID" value="OEV36946"/>
        <property type="gene ID" value="HS99_0027205"/>
    </dbReference>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="762" mass="83869" checksum="4A40F36838B14157" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8C4</accession>
    <name>A0A1E7N8C4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287030.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6832"/>
    <dbReference type="EnsemblBacteria" id="ARF78625">
        <property type="protein sequence ID" value="ARF78625"/>
        <property type="gene ID" value="B6264_06600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36929">
        <property type="protein sequence ID" value="OEV36929"/>
        <property type="gene ID" value="HS99_0027090"/>
    </dbReference>
    <dbReference type="OMA" id="FADIPVM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="336" mass="36926" checksum="F14ACB1EE0B20EC2" modified="2017-01-18" version="1">MFAYIIRRIFAAAALLLVVSAVTFAIFFLLPRFAGETADQLAAQYIGKNPSPEAIAAVKKNLGFEQPLYTQYWHFLKGLVSGAEYKFGPEPATCHVPCFGYSFKNHLEVWPEMTSRIPVTISLAIGAAVLWLVSGITTGVISALKPRSVFDRLSMGVALAGVSLPVFFTGALLLTVFSYEWPILDNLHYVDFTEDPLMWARNLILPWISLAFLYSALYARLTRAGMLETMSEDYIRTARAKGLVERKVVVKHGLRSALTPIVTIFGMDLGLLLGGALITEQVFSLNGVGQFAVQAINDNDLPKVLGVTLLAAFFIVVCNLVVDLLYALVDPRVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8S7</accession>
    <name>A0A1E7N8S7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0004380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556113.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000394.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81661">
        <property type="protein sequence ID" value="ARF81661"/>
        <property type="gene ID" value="B6264_24615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37068">
        <property type="protein sequence ID" value="OEV37068"/>
        <property type="gene ID" value="HS99_0004380"/>
    </dbReference>
    <dbReference type="OMA" id="HLTEWDE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="125" mass="13959" checksum="E3DBBF8B77CFC868" modified="2017-01-18" version="1">MDEYAVPILPSRDLDETQEFYGRLGFEPRGRWDGPAGYLIVVRGTVELHFRHDPGVDPLATAGSCYLQVRDADALHRDWARIGIPTDPGTGSRLTPVVDTDYRMREFALVDRSGNLLRIGSLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8T0</accession>
    <name>A0A1E7N8T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0004535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366240.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6694"/>
    <dbReference type="EnsemblBacteria" id="OEV37092">
        <property type="protein sequence ID" value="OEV37092"/>
        <property type="gene ID" value="HS99_0004535"/>
    </dbReference>
    <dbReference type="OMA" id="IDNGTHS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="3">
        <location>
            <begin position="138"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="343" mass="36788" checksum="38921F999A20F395" modified="2017-01-18" version="1">MKRRAAVIGLGHQALEDHLPGLLASNRAELVAVCDNDPDTLRAQQDTHDVPGFTRAADLLDNVAPDFVIVAVPHHAGRAVIEECAVRGVHVLKEKPFATSLSEARELAAICQQAQVELMVTLQRRFNPLHASVVQLLDQIGTPFLIDGQYTFHTDDPGAGWRGDVSQAGGGCIIDMGYHIVDLLLWYFGMPNRIMADFSTAALPDGGYDAEDTAVIQLGYDNDLYGTVLLSRWMAPKTEKLHVVGTLGSVLLTKGQVQRLDVHGKVVDELSRPQAPASAATAQIDYPSSCWRTAPTPTAPPTAARRSAPSAWPVPSRSTAPSRCPAARAGSSSRTTTTRTTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A9</accession>
    <name>A0A1E7N9A9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555153.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1290"/>
    <dbReference type="EnsemblBacteria" id="OEV37275">
        <property type="protein sequence ID" value="OEV37275"/>
        <property type="gene ID" value="HS99_0005625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="345"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="422" mass="43591" checksum="368011C78A68A0E9" modified="2017-01-18" version="1">MTAATIPRWAAEDVRSAHRRLDDAGNTAAGTPWAGLLLLDGPTHAATASSGKGLRGWQVPDGAIRSAVTTVVVAASPAGRFDQASAAPDRRGPGQPWFAEIGYAHCFALLMAGQVRHACRIAENGYRDEVAAGNTAVAGGWLALRGQVANVATAIADAEAASLLFDGGNSCLMVAPRLAELAVFGDQAGNQQTRRLADQEPENRLFVPWLTLSQAWTTAAGGDTTLAARQALAAADMAMALGQYAVEATASYDVARLGNPNAVRHRLAALADLVPGPVVPTMAGAAAALARSDPGALDVATAKFTELGMDLLAAETATAAAAVRHTRVSPSTIACPNATTPLLQLTAPLVELTSRERDVALLAANGLTSPAIGHRLGLSARTVDNYLGRVYQKLGVTGRRDLAPLVVGGRPHPPIQAEGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R8</accession>
    <name>A0A1E7N9R8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0005210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556543.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6155"/>
    <dbReference type="EnsemblBacteria" id="OEV37436">
        <property type="protein sequence ID" value="OEV37436"/>
        <property type="gene ID" value="HS99_0005210"/>
    </dbReference>
    <dbReference type="OMA" id="WQHPAAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="174" mass="19635" checksum="C2F33603B5AD6839" modified="2017-01-18" version="1">MSRADEELLRTLYAEHAGPLLHFVLRLTSGDWQWAEDVVQETLLRAWQHPAAFDPARGPARAWLCTVARNLVIDAHRARRARPTEVDGQALERLAEQTPGEDEIEQTLQSWAVAEAIRTLSAEHRAVLLETYYRGRTMVEAAEVLGIPVGTVKSRTYYALKALRLALQERGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9U6</accession>
    <name>A0A1E7N9U6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2530 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287078.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000113.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7930"/>
    <dbReference type="EnsemblBacteria" id="ARF79105">
        <property type="protein sequence ID" value="ARF79105"/>
        <property type="gene ID" value="B6264_09410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37467">
        <property type="protein sequence ID" value="OEV37467"/>
        <property type="gene ID" value="HS99_0025945"/>
    </dbReference>
    <dbReference type="OMA" id="QLPFYGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="100" mass="10603" checksum="5CFA9F09BBD3151D" modified="2017-01-18" version="1">MPKTPLHPSPPPLEANDVAIVGGGTVLWFVAFLALLPFQGTLSDHGHGTWPWICLSGGLLGLIGLWYCRARRDAIARSRAAEAAAREAETDGKGPATRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Y0</accession>
    <name>A0A1E7N9Y0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366628.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7966"/>
    <dbReference type="EnsemblBacteria" id="OEV37496">
        <property type="protein sequence ID" value="OEV37496"/>
        <property type="gene ID" value="HS99_0026115"/>
    </dbReference>
    <dbReference type="OMA" id="ASEMCGK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026367">
        <property type="entry name" value="FxsC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04276">
        <property type="entry name" value="FxsC_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="54474" checksum="A635E0CD2E7F180C" modified="2017-01-18" version="1">MTDRGWDEDEARPYFFLSYAHTPKSGARGAGDPNHWVRQLYRDLCEAVLQLTTVPAGVPVGFMDESMHQGELWAERLSEELASCRVFVPLYSPRYFNSVPCGQEWHAFTRRPVYPATIDAERTSGIVPVLWAPMSRYRLPKVASELQFNHAGFGPDYATEGLYALMKLSYFRAAYELAVHRLAARIVQVAEETVIPVGRRLDFNTLPSAFNVTAPTKQLRISVLTYHQGELPPDRNPDFYGARRTDWHPYRPAGSPIAQHAVRLARQLGFQPTVHEFDDEVESIIEGNAEAPGLLLLDRWALRDPHRRELVRRFDRCDATWVSVLEPWNSDDPECDGGGRELVELSDQILRITRRAGRPSFLGVTGPTGLDTLEDFDDALPRAAMKAKYAFESRTRAEPEEPPTPRPSLREAFRREPGAYGPDGFGGHRPDQYGPDPVDRDHDPDDGTDHRNARTNDHRDTRDDRDGGDDPDAGMAPLGGPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA43</accession>
    <name>A0A1E7NA43_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0026220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387209.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000738.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7987"/>
    <dbReference type="EnsemblBacteria" id="ARF79058">
        <property type="protein sequence ID" value="ARF79058"/>
        <property type="gene ID" value="B6264_09135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37514">
        <property type="protein sequence ID" value="OEV37514"/>
        <property type="gene ID" value="HS99_0026220"/>
    </dbReference>
    <dbReference type="OMA" id="TEAFSWL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="418" mass="41790" checksum="B5049BCCC62B88FB" modified="2017-01-18" version="1">MGYLALLRAPHVTRLLLGTLLGRLPAGMTALVIALALRESGVPYGRIGLATSVYALAAAVGGPVLGRIVDRTGQPRVLLASAVIAGGGYALLALAPGSPVAAPLGAAVAGLAMPPLEPCLRSLWPDVVEDEQLDTAYAFDSASQQILYVAGPLAVAGIAGLFSPVAALWVAAGLGLAGALVVATAAPARAWRAPAREKSAGLLGPLRSPGLVLLLVGLAGAGWAVGAQNVLFIAYAERHAGGLPGGGGTLLALAALGGLLGALAYGTVNWRQSTATRTWLMALAMAASYLPLVTLPGPYPMAALAFVSGILLAPLLAAAFVLVAELAPTGTVTEAFAWLVTLFATGNSLGYAVSGHLAEGSSLRPVAVCAAGGIALGAAVLFGARRWFRSAPTAPRFEPVGAVEPAEPVEPAEPLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAI6</accession>
    <name>A0A1E7NAI6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">nnrE</name>
        <name evidence="9" type="synonym">nnrD</name>
        <name evidence="12" type="ORF">HS99_0025745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280825.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1645"/>
    <dbReference type="EnsemblBacteria" id="ARF79964">
        <property type="protein sequence ID" value="ARF79964"/>
        <property type="gene ID" value="B6264_14535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37707">
        <property type="protein sequence ID" value="OEV37707"/>
        <property type="gene ID" value="HS99_0025745"/>
    </dbReference>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="400"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV37707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="491" mass="48474" checksum="1B776DDCBB19A447" modified="2017-01-18" version="1">MRHAHPVETVRAAEAALMARLPEGTLMQRAAAGLAATCARLLTRRRGRVYGSRVTVLAGSGDNGGDALYAGAALARRGARVTAVLLTPEKAHPGGLAALRAAGGRVTAEQEVGLAEFSRADLVLDGIVGIGGRGGLRPGAAPYARAGRSGIVVAVDLPSGVDADTGEVAGEALRADVTVCFGTYKPGLLIDPGAEYTGAVQLVDIGLELPEPEVTALQHADAAALLPLPGAESDKYRRGVVGVAAGSARYPGAALLAVAGALRGGAGAVRYVGTAAEEVVRRFPETLVTEGGPAGAGRVQAWVVGPGGGEGARQALTEALASDVPVLVDADGLTELGRLGPDALAGRTAPTLLTPHTGEAARLLAGAEGGAPPAAEDLAAARLATARRLAAAYRATVLLKGSTTVVADPGGAVRVNPTGTSWLATAGSGDVLAGLAGSLLATGLSPLDAASLGAYLHGLAAREAAGDPGAPVTALAVAGALPTAWRAVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB35</accession>
    <name>A0A1E7NB35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597565.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2129"/>
    <dbReference type="EnsemblBacteria" id="ARF79445">
        <property type="protein sequence ID" value="ARF79445"/>
        <property type="gene ID" value="B6264_11420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37895">
        <property type="protein sequence ID" value="OEV37895"/>
        <property type="gene ID" value="HS99_0023750"/>
    </dbReference>
    <dbReference type="OMA" id="WKPGELG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="457" mass="49677" checksum="2B8D8A5CA276D35B" modified="2017-01-18" version="1">MAKLAGQLVEALDGLLGIPVPLRVQAWDGSVAGPPGAPTVVLRNRRGLRRLLWQPDELGLARAYVAGDLELAPGTDLYETLSAVARFAELPEIRTMALGPRDVLGAKGRRVLAVALRAGALGPEPTPPPEEVRKARGRLHSRSRDRAAISHHYDVGNDFYGLVLGPSMVYSCAYWTPEAKSLEAAQEAKLDLICRKLGLRPGMRLLDVGCGWGSLLLHAAEHYGVTAVGVSISKEQVALARARVEEAGLADRVDVRLQDYREIVDGPFDAISSVGMAEHVGSEQYRIYADGLYRLLAPGGRLLNHQIARRPDYPGEPHRTSPFIDRYVFPDGELSPVGSTVARLEEAGFEVRDVEALREHYGLTLREWVANLEANWTEAVRLVGIGRARVWRLYMAASALAFEQNRIGINQVLAVRSTEAGGAGLPPTREEWLVRPAPGATAATPAGTDLGDRRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBL0</accession>
    <name>A0A1E7NBL0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone HtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0023030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043389063.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000249.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000038_gene3018"/>
    <dbReference type="EnsemblBacteria" id="ARF79712">
        <property type="protein sequence ID" value="ARF79712"/>
        <property type="gene ID" value="B6264_13070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38077">
        <property type="protein sequence ID" value="OEV38077"/>
        <property type="gene ID" value="HS99_0023030"/>
    </dbReference>
    <dbReference type="OMA" id="TEPEIHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="634" mass="68099" checksum="875808C41191C635" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBT2</accession>
    <name>A0A1E7NBT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0023995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366681.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2081"/>
    <dbReference type="EnsemblBacteria" id="ARF79486">
        <property type="protein sequence ID" value="ARF79486"/>
        <property type="gene ID" value="B6264_11665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37933">
        <property type="protein sequence ID" value="OEV37933"/>
        <property type="gene ID" value="HS99_0023995"/>
    </dbReference>
    <dbReference type="OMA" id="PPWFDCD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV37933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="20342" checksum="F9D4823326219D53" modified="2017-01-18" version="1">MTTPYDVIVPAGGAARRFDGADKPGLTVGETTLLDRVLAACAGARTTVVVGPARPTTRAGVRWTREQPPGGGPVAAVAAGLDLVTADTVLLLAADLPFLDRRTVERLASALEEAGPYTDVAVLVDAGGRDQPLTAAYRTAALRAALAALGGDPAGQPLRRLVGGLNRLRVADTDNVAYDCDTWEDLEQARERDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCA3</accession>
    <name>A0A1E7NCA3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0022625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037829531.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4146"/>
    <dbReference type="EnsemblBacteria" id="ARF80157">
        <property type="protein sequence ID" value="ARF80157"/>
        <property type="gene ID" value="B6264_15650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38320">
        <property type="protein sequence ID" value="OEV38320"/>
        <property type="gene ID" value="HS99_0022625"/>
    </dbReference>
    <dbReference type="OMA" id="RTVNTEM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="489" mass="50780" checksum="425ED6972CEAAE8F" modified="2017-01-18" version="1">MATVPSVSNSITVRLEVPARGNAVSAITTAVESSGGSVTGLDVTASGLEALRIDVTVAASSVAHGEEIVEKLRAIDGVSIGKVSDRTFLMHLGGKIEMSSKLPIRNRDDLSMIYTPGVARVCMAIAENPEDARRLTIKRNSVAVVTDGSAVLGLGNIGPAAALPVMEGKAALFKRFAGIDAWPICLDTQDTDEIVAIVKAIAPGFAGINLEDISAPRCFEIEARLREALDIPVFHDDQHGTAIVVLAALTNALKVVGKEIGDIRVVMSGAGAAGTAILKLLLAAGVEHATVADVHGVVHLGRDDLNDSLRWIAEHTNRSGRTGSLKEAVAGADVFIGVSAPNVLDGDDLATMAEQAIVFALANPDPEVDPAVARQTAAVVATGRSDFPNQINNVLVFPGVFRGLLDAQSRTVNTEMMIAAARALATTVGDDELNANYIIPSVFHKDVAKTVATAVRDAALADAQAPTPSRPTPGIVGTLDTSAFPTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCH3</accession>
    <name>A0A1E7NCH3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="9" type="ORF">HS99_0021000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283226.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000224.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene256"/>
    <dbReference type="EnsemblBacteria" id="ARF82218">
        <property type="protein sequence ID" value="ARF82218"/>
        <property type="gene ID" value="B6264_28055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38391">
        <property type="protein sequence ID" value="OEV38391"/>
        <property type="gene ID" value="HS99_0021000"/>
    </dbReference>
    <dbReference type="OMA" id="TSYYSGC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="608" mass="65473" checksum="E08D98C6146222C0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCV9</accession>
    <name>A0A1E7NCV9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0022650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283977.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000104.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4142"/>
    <dbReference type="EnsemblBacteria" id="ARF80153">
        <property type="protein sequence ID" value="ARF80153"/>
        <property type="gene ID" value="B6264_15625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38323">
        <property type="protein sequence ID" value="OEV38323"/>
        <property type="gene ID" value="HS99_0022650"/>
    </dbReference>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="33248" checksum="C2B0773857307CF5" modified="2017-01-18" version="1">MRAQFVLSEIGVGLRRNLTMTIAVVVSVALSLALAGSSLLVRDQVNSMKGYWYDKVEVSIYFCTKADARNSPQCDKGAATDQQVHDIKDQLDKMTSVVQSSTYESSAEAYKHWKEMNPDNPLISVLGPDAMPQSWRVKLNDPTKYDVIQSAFAGKPGVKSVEDQRKILENLFGLLNGLQTAAFVIMVLMLFVALLLIVNTVRVSAYSRRRETGIMRLVGASNFYVQMPFIAEAAFSALLGAGLASGLLIGGHFFVQNWLADRVQFIHFIGLSSVLAVIPLLVVVGMGMAGIAAFFTLRKYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND13</accession>
    <name>A0A1E7ND13_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene633"/>
    <dbReference type="EnsemblBacteria" id="ARF77623">
        <property type="protein sequence ID" value="ARF77623"/>
        <property type="gene ID" value="B6264_00645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38596">
        <property type="protein sequence ID" value="OEV38596"/>
        <property type="gene ID" value="HS99_0020230"/>
    </dbReference>
    <dbReference type="OMA" id="APGNWWT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="187" mass="20183" checksum="6914A17B36040FD6" modified="2017-01-18" version="1">MSDDLLFSKINHGFDHLDADGDGLLTERDHVLMGHSVARSLGHQEGSEAEAVIVRAYLTVWHDLHLAGKPTGTEAITREQFVASTGALADDPVAAREIFGALAGSFLAVADADHSGTVDAGEFFVFQRGHFAGLSRDDADEAFRHLDLDGDGTLSADEFTNAIIEYWTSRDPEAPGNWWTGKPPHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDF4</accession>
    <name>A0A1E7NDF4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">HS99_0020220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene635"/>
    <dbReference type="EnsemblBacteria" id="OEV38711">
        <property type="protein sequence ID" value="OEV38711"/>
        <property type="gene ID" value="HS99_0020220"/>
    </dbReference>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="141"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV38711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="49893" checksum="1835F8AD51950A11" modified="2017-01-18" version="1">MDVVAGVEPRIAAAIGRELEDQRASLKLIASENYASPAVLLAMGNWFSDKYAEGTVGRRFYAGCRNVDTVEALAAEHARELFGAEHAYVQPHSGIDANLTAFWAVLSQRVESPALERAKVRNVNDLTEQDWAQLRQELGNQRMLGMSLDTGGHLTHGFRPNISGKMFEQRSYGTAPETGLIDYDALRETAREFRPLILVAGYSAYPRLVDFRRMREIADEVGATLMVDMAHFAGLVAGKVLTGDHDPVPHAHIVTTTTHKSLRGPRGGMVLSNAELAEHVDRGCPLVLGGPLSHVMAAKAVALAEARRPEFRAYARAVVDNAQALAEGLLRRGGKLVTGGTDNHLVLTDVSGYGLTGRQAEAALLDSGIVTNRNSVPQDPNGAWYTSGVRLGTPALTTRGLGTAEMDEIAALIDTVLRGTTPTTTANGAPSKANYALDESLRDGIAKRAADLLAPFPLYPGVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDS9</accession>
    <name>A0A1E7NDS9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290259.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000577.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7380"/>
    <dbReference type="EnsemblBacteria" id="ARF81195">
        <property type="protein sequence ID" value="ARF81195"/>
        <property type="gene ID" value="B6264_21875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38788">
        <property type="protein sequence ID" value="OEV38788"/>
        <property type="gene ID" value="HS99_0019140"/>
    </dbReference>
    <dbReference type="OMA" id="PGGLVMR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33256" checksum="32647D89BAC72AB3" modified="2017-01-18" version="1">MTSRKGRSRRNSDCTAGGLRPALRAPHRSRRHEGVEQAFVIGVLTSAADFARARAWGVSDAPDHERYLADTAELLADALERFETVRARMFHPQDFEEFCVLHGLDPAEPAARDRYLVNPPLRTQLLVYQGEELAGDFVPRLVRARENGLTLRHADLLLDGALLGSAGPAEADEEHACWVRAAHQRGSEVFRRMLVGAGAGVYELRLRVDAPGGRLTAAARVLQWEDGVVRINDEELELVCAVLCAGLALELPAVAVLHGSQGSAASCGEYLPAAWAWSSGGPDWAPAARPVRLDGVAAQPGYSLGTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE79</accession>
    <name>A0A1E7NE79_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0017850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557328.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38974">
        <property type="protein sequence ID" value="OEV38974"/>
        <property type="gene ID" value="HS99_0017850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="117" mass="12112" checksum="6F43AA7106B28D0E" modified="2017-01-18" version="1">MSVGRDAITQQRAAQPGIGALALEVVPAYLSDRQAEDSGLARLANDIGITTEEILACRRYAMSGDVRAGQICRSGSEKVRPPAASGRRAGAGAAALSLSGWRKSAPCSTGSSRRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEL6</accession>
    <name>A0A1E7NEL6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0019670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6513"/>
    <dbReference type="EnsemblBacteria" id="OEV38933">
        <property type="protein sequence ID" value="OEV38933"/>
        <property type="gene ID" value="HS99_0019670"/>
    </dbReference>
    <dbReference type="OMA" id="HERWRQS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="400" mass="41393" checksum="A1C01B074D018B3B" modified="2017-01-18" version="1">MHAETGKAQEQPGAVRSGVDRRALIAGGGAVLAAGVGAGVVALGRGRPAASSPPPPSAPAVAFHGERQAGVTALQQPATLLLALDLAPAATSDGRAALRSLLGELTRVLADAAGGAAADPRLRGGEPAQLSSLVGVGPGLAARLGLNVPPALADLPAFPGDRLDPARGGGDLVVQLCAADRWPLTVVAELLAAAARSAGGTVRWTQPGFLPRTPAGTTPRNLFGYKDGTANPDATEAKQWVWGPPGPYEHGTVLVYRRIRMDTAAFAALPEDRRDLAMGRRLTDGAPLTGTAEHDDPDIYAKNPDGSYVIPNTAHVRLSSPRLDSGARMLRRGYSYDDAPDDRGLLFCAFVRDPEQFTRVQNRLAAKDALNPFLVHTASAVAYVLPGAREGGVLGEGLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NES6</accession>
    <name>A0A1E7NES6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550109.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3483"/>
    <dbReference type="EnsemblBacteria" id="OEV39174">
        <property type="protein sequence ID" value="OEV39174"/>
        <property type="gene ID" value="HS99_0000115"/>
    </dbReference>
    <dbReference type="OMA" id="GWQGSPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="182" mass="19559" checksum="3EE3A865A01AC68C" modified="2017-01-18" version="1">MPDRITYLVVPGYQNSGPAHWQTRWEAAEPEAFRRVEQADWDHPEQQDWAARVDAAVAAAAVEGPVVLVAHSLGCITAARWVAGASSERTAAVRGALLVAPADVDTAEVPELLGFRPVALERFPFPTVVVSSTDDPWVTPARAREFAAAWGASHVEAGAYGHLNSESGLGDWPEGRKLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEV4</accession>
    <name>A0A1E7NEV4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0000275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285182.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000410.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39204">
        <property type="protein sequence ID" value="OEV39204"/>
        <property type="gene ID" value="HS99_0000275"/>
    </dbReference>
    <dbReference type="OMA" id="RAYYTEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="177" mass="19433" checksum="DCEC0DB543132B82" modified="2017-01-18" version="1">MTDTAPSRSDLWTVTTADVTSPEAEALLREYYYDVANRYYRLHLGREGTPEQLEAGFADSPSDDLTAPTGLFLLGRYHGAAQSCAGLRRHDATTVELTRVFVRPGLRGTGGGARLLAAVDEAARAMGAERIVLDTRLDLVEARALYLRNGYREIPAYGETGPYSEIWYGKELTAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEZ0</accession>
    <name>A0A1E7NEZ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0000695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550210.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3604"/>
    <dbReference type="EnsemblBacteria" id="OEV39270">
        <property type="protein sequence ID" value="OEV39270"/>
        <property type="gene ID" value="HS99_0000695"/>
    </dbReference>
    <dbReference type="OMA" id="LLTRVWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="471" mass="51421" checksum="0C83B970ED66631E" modified="2017-01-18" version="1">MTTETVPQNQQGRQSLSTSAARNLATTTKTVPQMLGITPRYLLRALPWVDLEAGVYRVNRRRGFILGDGLVSTYVDGGGATRVIAEDLRELAFLSQVDGPVLSALAAGFTEREVAPGELIVDADAPADQLHIIAFGRAEKRATGTYGDDALLAVLGEGDFFDAPAWASGTAMPYRVKAVSACTVLSLDRGMLAELADREPSLRARLDEFTAGPAPTDPEHPIDLQSGHTGEPYLPETFVDYDERPREYELSIAQTVLKVHTRVADIYNSDIDQVDAQLQLTVEALRERQEWEMLNHAEYGLLNNVVPTQRVRTRGGAPTPDDLDELLTRVWKQPAFFLAHPRAIAAFGRECTRRGVPPQVVELFGSPFITWRGVPLLPSDKLDLNGSANSAPGTTNILLMRVGEERQGVVGLRPSKVPDEVEPGLAVRAMGVDRQAITSYLVTSYFSTAALVDDAIAVLQNVEVSNYHDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFD7</accession>
    <name>A0A1E7NFD7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7531"/>
    <dbReference type="EnsemblBacteria" id="OEV39420">
        <property type="protein sequence ID" value="OEV39420"/>
        <property type="gene ID" value="HS99_0001595"/>
    </dbReference>
    <dbReference type="OMA" id="RGDAHRY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="389" mass="40575" checksum="EC52B8E953079D81" modified="2017-01-18" version="1">MDGWVRAGLLVAVTVGAFVEVGSPHRHYGWLVDVFALAAVGVVGAAAALGSELAAVPAGQRNRLDREPGPDATVPACRYVAGPSAPTAQPAKPRPFLRERPTDPIVPRFGDGARAQGFPWLLPERTVQNGIAADEATVGALTIRAASVVGPGHRCDQPAGPRQDSYRIGRTRDSRYAIVAVADGLSSAAWSDTGATTASSQAVTLLREQIEAGDFDRLDVKELYGRVAESIAGQAAGRGVGTAHLATVLITAVIAEPDASGTARAWVGWLGDSSAWTLDPRVPRWQFSAGQAKDREGPVVSNEVAGRLPDTPHLALDGYVTLAPGAALALVTDGIGDAWADPAGNVNEYFANAWRSPVPATRFTADVGFDAPQCLDDRTAVVVWNGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFH3</accession>
    <name>A0A1E7NFH3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000657.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000073_gene7533"/>
    <dbReference type="EnsemblBacteria" id="OEV39422">
        <property type="protein sequence ID" value="OEV39422"/>
        <property type="gene ID" value="HS99_0001605"/>
    </dbReference>
    <dbReference type="OMA" id="VYRPAVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="23781" checksum="562A939FFF8B8028" modified="2017-01-18" version="1">MSLCLPTYVVIDASSSMKPHEAVLNATLSRLHYNLATNPRVSEFARVSVIAFSTDVHVVIPMSDMEQVPNMPEVICGGRTDYGKTFDRLRECIEQDVSSLRAQHYSVLRPTVFFLTDGGPTDANWRKSFRELVDRNRPRYPHVIAYGFGGAERGVLQVVATKALFIADGTDTESALSGAISGLLNTLIASSQTGQMQIATDVKGFEYVQVAQEYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFS3</accession>
    <name>A0A1E7NFS3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0002205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555656.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000228.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6782"/>
    <dbReference type="EnsemblBacteria" id="OEV39524">
        <property type="protein sequence ID" value="OEV39524"/>
        <property type="gene ID" value="HS99_0002205"/>
    </dbReference>
    <dbReference type="OMA" id="IELHITF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV39524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="39421" checksum="8826D4993A016016" modified="2017-01-18" version="1">MHGSVRLGRVFGIPLRIHWSAPVLILFLGVGLAGQTLPAWVPGRSSAAYGFAGLAGALLLTVSLLLHETAHAVTARRAGIRVDDMTVFALGGVTRMGRPPSPRLQFAVAGIGPLTSLVLGGLTLAAGLGALHTVHWAMPSAVLLWTGWTNLLLGAFNLLPAAPLDGGRLLQAAVWWRRGDRERAERVAGRAGQAVGLLLSAAGWVELLYGNGAGIWFVLIGLFMWSSATAEVRRAALVAALRGVRIGQAMIPATAAPDWLTADRLLADPAARAAHQPVVPLVDVDGRASGLLDLRRLTAVPPAHRGEVRAREFATPLSRCLTAAPQDDLVEVLDRAAAPPPVLVLDDGRLAGIVTAEVLDRLARRRLAATGTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFW9</accession>
    <name>A0A1E7NFW9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0002475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285769.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6726"/>
    <dbReference type="EnsemblBacteria" id="OEV39564">
        <property type="protein sequence ID" value="OEV39564"/>
        <property type="gene ID" value="HS99_0002475"/>
    </dbReference>
    <dbReference type="OMA" id="GRIPMRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="35841" checksum="77CF34E4DB63FE6C" modified="2017-01-18" version="1">MSTLALDAAGLEKLVSAAVAAPSIHNSQPWRFHLQPATSTLEVRADRSRAVPAADPQGRALHISVGAAILNLRVAARHLGWAPEVRLLPDPADPDLFAAVRLDGAATVPAPGTERLFEAIWRRHSIRTPFTGEPVPQAVLDELVAAARTEHTALQLPDHAETTRLLHLTAEAERRSTTDEAQRTESRSWIRTGDAEAQPYGIPVTALGPQDQAGHLPVRDFAALRAAEHQAPAPFEHEPRIAVLTTEHDTPEDWLRAGLALEHVLLAATVHGVRASLLHQAMEWPYLRWEARDPHRGPGYVQILIRLGYGPEGAPTPRLAAGNVLDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY4</accession>
    <name>A0A1E7NFY4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367055.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2757"/>
    <dbReference type="EnsemblBacteria" id="OEV39621">
        <property type="protein sequence ID" value="OEV39621"/>
        <property type="gene ID" value="HS99_0002815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32626" checksum="0D9646C62766749F" modified="2017-01-18" version="1">MQRLDPRLLATLEAVVRHGSFNSAARELGYSAPAVSQQIAELERRTGLRVLERRPVRPTPAGEVLLDAEQGVRSALAAASVELDAMRAGTAGRIRLAAFASAATSIVPKALAQLHTTYPDVRVSLSQLEPEAGYSRLKRGDMDLTLSYDYDFIPQPPPRTLRRTLVARDPVVAVVPAGHHLADREVIDLASLASETWIAAPEAALRLELLAQIAKTPGFRARLEYEGDDFNTVLGFVAAGLCVAVMPQLALPRGTTQVVARPLAEPELTRFIYAVRIDTRHAPHALLALEQMLAAQALAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG15</accession>
    <name>A0A1E7NG15_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550318.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000512.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2748"/>
    <dbReference type="EnsemblBacteria" id="OEV39612">
        <property type="protein sequence ID" value="OEV39612"/>
        <property type="gene ID" value="HS99_0002770"/>
    </dbReference>
    <dbReference type="OMA" id="ERFFYVP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="21687" checksum="F547273000DD6154" modified="2017-01-18" version="1">MPKDVIELITADHREVEKLFDRLQAGGADRVAVLDRVGALLVAHSRAEEERVYPVVAKRAPGEKDQVAHSEDEHEQAEGLIRRLQATDPGSEKFDSLVTELVEAVRHHVETEESEVLPALREAVDSKQLHELGGKFRERREEALAEAEREAAERRRGGEPTKDELYRQAQEAEISGRSSMTKQELADTLEHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG60</accession>
    <name>A0A1E7NG60_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0003100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385612.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000072.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2815"/>
    <dbReference type="EnsemblBacteria" id="OEV39667">
        <property type="protein sequence ID" value="OEV39667"/>
        <property type="gene ID" value="HS99_0003100"/>
    </dbReference>
    <dbReference type="OMA" id="DSDSWIP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199123" description="Beta-xylanase" evidence="5">
        <location>
            <begin position="38"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="36"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="360"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV39667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="490" mass="50806" checksum="73ED207B90F67C80" modified="2017-01-18" version="1">MSLRRTLNGIHHAWTAAVVLALVLATGALAATTPAAAAGSTLKAAAEANGRYFGTALSDGDLGVGGETAVVGAQFDALTPTNEMKWETVEPAPGSYDFGPGDQLVQFARAHGMRVRGHNLVWQNQLPGWMSNLPLNQVRSAMEAHITAEAGHYKGQVYAWDVINEPFNGDGSLVPDAFYRAMGPDYLADALRTAHAADPGAKLYINDYNIEGVNAKSDALYSLARSLLAQGVPLGGIGFESHFVVGQVPTDLRANLQRFADLGLDVAVTELDDRIQLPASGGALQQQAADYAAVVRACLAVSRCVGVSQWGVDDAHSWIPGTFPGYGAATMYDDNDRPKPAFAATLSALGGSSTGGGGGTTGELRAAGAGKCLDVPNGSTTAGTQVQLYSCWGGINQIWTHTAADQLSVYGGAGRMCLDASGQGTVPGTKVVVWPCNGQANQQWHVNADGTVTGVQSGLCLDVSGGSTADGAPAQLWTCSGRSNQQWTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGC3</accession>
    <name>A0A1E7NGC3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279583.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000683.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2943"/>
    <dbReference type="EnsemblBacteria" id="OEV39769">
        <property type="protein sequence ID" value="OEV39769"/>
        <property type="gene ID" value="HS99_0003730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="77" mass="8315" checksum="C3C34738DEB1CE9E" modified="2017-01-18" version="1">MTFEQVKEILTDRCGLPSAPVTPDAPLASAGVDSMALVMLSLHLEDRFGVEISEDQLSTATCVDDMAKLISRYAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGD8</accession>
    <name>A0A1E7NGD8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39695">
        <property type="protein sequence ID" value="OEV39695"/>
        <property type="gene ID" value="HS99_0003265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="86" mass="9443" checksum="E0AEA0EBD5C92685" modified="2017-01-18" version="1">MAAAGLAVPVVFLRRHRTGDLYAWLVAACGLGAPLLRRYVDVGTLGPLPNMYEPIWFEEKIRAAWAEGIATAALTVLLFGHRRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGS6</accession>
    <name>A0A1E7NGS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0001850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481267.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000671.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000049_gene5107"/>
    <dbReference type="EnsemblBacteria" id="OEV39825">
        <property type="protein sequence ID" value="OEV39825"/>
        <property type="gene ID" value="HS99_0001850"/>
    </dbReference>
    <dbReference type="OMA" id="YGLVEPA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV39825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="398" mass="41158" checksum="36F114957EC87A51" modified="2017-01-18" version="1">MAVVGGGMAGARFAERYGALGGPGTVTVYGAEPRAPYNRVLLADVLTGRYDAESIALPLGGAEARPGCEVMALDPAARTLALADGTVEPWDELVLATGSNPVLPPVRGLRRPDGPGLAEGVHTLRTLEDCGRLAEEAVTAKRAVVIGGGVLGVSAARALAALGVRTEIVHQGTHLIERQLDGEAAEVLRERLLALGVETYARNRARAVHGGDRADAVELANGYRLDCDLVVLACGTRPRTALAYGAGLPVGTGILVDDRLATAGPHVSAIGDCAEHRGTVHGLAGPAWEQADALARRLSGADPDARYTGSLQRARLSTGDLEYAAFGAVDETLDPGLDVLRIADATRGSYKKLVLRGTRLVGAILLGDLATVDALAGAFESKEPLGGHPLHLLTRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGX6</accession>
    <name>A0A1E7NGX6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279570.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2938"/>
    <dbReference type="EnsemblBacteria" id="OEV39875">
        <property type="protein sequence ID" value="OEV39875"/>
        <property type="gene ID" value="HS99_0003705"/>
    </dbReference>
    <dbReference type="OMA" id="TARIYDY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="28934" checksum="944D2FF293CCF6CB" modified="2017-01-18" version="1">METDFEQPPQVDLRTDRAHSARVYDYLLGGKTNFPADREVGDRVLADLPTARAGAAAARAVMHRMVRRLAEEHGIRQFLDVGTGIPTAPNLHEVVQAVDPACRVVYVDNDPIVLAHSRALLTSTPEGRTAYVEGDLRDPEKFLADPAVAATLDLTRPVALTLINIVHFLSDEAAHPPVRKLLDALPSGSFMALTAGTADNAPDQVPVGARRYAEAGIEVYARSHAEVERFFAGLELDDPGVVLVNRWHPEPGAADGEVSLYGGVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV09</accession>
    <name>A0A1E7MV09_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator CynR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0016280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550566.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2978"/>
    <dbReference type="EnsemblBacteria" id="OEV32272">
        <property type="protein sequence ID" value="OEV32272"/>
        <property type="gene ID" value="HS99_0016280"/>
    </dbReference>
    <dbReference type="OMA" id="FATRGHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="314" mass="34120" checksum="5B8F0B33CD7A5BE3" modified="2017-01-18" version="1">MALELRHLRYLLAVADHGNFTRAAEELHISQPTLSQQIKQLERTLGTQLLDRTGRTVRLTDAGQAYAHHARGALRDLAAAERAVHDVQDLSRGQLRLAVTPTFTAYLVGPLTAELHARHPGITLTVRETSQDRIEAGLLTDEFDLGIAFDGPHLPGVTATALFTETLTLVTGVGADHPTADHPIADPPTTDQPGPLPVRDLGDRQLALLSGDFATRGHIDGYFAQHRVSPRIAVEANSVQALTEVVQRTPLATVLPEAVTHEHPRLARIPLEPPLPTRTVTLLRRSDAYRSAAARAFTDLAHALVRTRGYPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD0</accession>
    <name>A0A1E7MVD0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0016990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000487.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32390">
        <property type="protein sequence ID" value="OEV32390"/>
        <property type="gene ID" value="HS99_0016990"/>
    </dbReference>
    <dbReference type="OMA" id="CTPVCGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="19555" checksum="9548DDAF21543DC5" modified="2017-01-18" version="1">MAVDGSNMAHAVIETAVKERTRLQTGRSRATALVVLVLLAGLGLFLALVVGKSDPTSAPTCNGTTMTRNDECRIWSNHGGGGTYGYQEMIDRRESGKGVWQVVGFVGTGLSVVLMGVAVTKLNPERPWGKPVTAVCPRCYQPNLREKLTVHTISRGRTNYRYSGIVTLCTPVCGFSAVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVD1</accession>
    <name>A0A1E7MVD1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0016975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553875.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6985"/>
    <dbReference type="EnsemblBacteria" id="OEV32387">
        <property type="protein sequence ID" value="OEV32387"/>
        <property type="gene ID" value="HS99_0016975"/>
    </dbReference>
    <dbReference type="OMA" id="QYPGGYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="345" mass="34981" checksum="082B681E1656E9C0" modified="2017-01-18" version="1">MAATTPTPAVRSVQVAAPGAAPELVEVPLRDPGPGAVRIAVEACGVCHSDLLIAAGMLPGTTFPVTPGHEIAGQIDALGDGVQGWKVGDRVAVGWFGGSCGRCDACRSGDAIHCALLQVPGAAYPGGYADSVIVPADALAAVPDELTAAEAAPLACAGVTVFNALRRAAARPGDTVAILGLGGLGHLGVQFAHAMGFRTVAIARGSEKEPLAHELGADHYVDSTAGSVADVLQALGGAKVVLATVTDADAMSATIDGLGRRGELVIVGVSPDRLAVSPLQLLNGDRRIYAHSSGAAVDIQDTLRFAARTGVRAWIEELPLEQTGAAVAKMTNGRARFRMVVTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVZ9</accession>
    <name>A0A1E7MVZ9_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="11" type="ORF">HS99_0015090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000272.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3818"/>
    <dbReference type="EnsemblBacteria" id="ARF78360">
        <property type="protein sequence ID" value="ARF78360"/>
        <property type="gene ID" value="B6264_04990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32600">
        <property type="protein sequence ID" value="OEV32600"/>
        <property type="gene ID" value="HS99_0015090"/>
    </dbReference>
    <dbReference type="OMA" id="NCQRNGV"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="208" mass="23004" checksum="21FE6C6A7B4909F7" modified="2017-01-18" version="1">MEPLITHTGQAVALRRDDIDTDQIVPAEYCKRVVKSGYADALFARWRQEPDFVLNRPAHAGATVLLAGRNFGIGSSREHAVWALKDGGFVAVVASGFGDIFRRNAMNNGLIPVDQPVEVVQELMAEAERDPSFTLTVDLQQLRLVVGGRSWPFEAEQRARELLLQGLDTIELTMRRGELIEAYERRRPSWLPTVPVGSGSEHATGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWE1</accession>
    <name>A0A1E7MWE1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0040070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000089">
        <property type="protein sequence ID" value="OEV32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284407.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8134"/>
    <dbReference type="EnsemblBacteria" id="ARF79763">
        <property type="protein sequence ID" value="ARF79763"/>
        <property type="gene ID" value="B6264_13380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32563">
        <property type="protein sequence ID" value="OEV32563"/>
        <property type="gene ID" value="HS99_0040070"/>
    </dbReference>
    <dbReference type="OMA" id="DAYVYFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="445" mass="48689" checksum="9CF793675AB16BDF" modified="2017-01-18" version="1">MVNPALVDPATIRATVAEAWIRGHPLLRTYRALYAQALDDADPGYVGGFGVFRHTAHPATPADTDAVTPDNDTLPSHAWLDLRAEPWVLSVPAQDRYHVFAVHELDALHAGLIGSRTTGQDAGDYLVAGPDWQGEPPPRLKGVIRTATRLVALVGHTRLTGNTPADLAALRAVQEQYRLRPLHEYAGTPAPAPAPEPVWPVWRDEVLESVEFLTFLDFLLGFFPLTDGLPPAETGLRGRLTDLCIDGRGEFEPAVLPLEVRAEFARGIADGRVRLTRALAELRDSAQLFGTREQLGADFLRQAVAAELGPYGLPAEEVWYGRWAADSEGRRPPNASDRDHLIRFAPDALPPARFFWSATVYALPDHRLVDNTLDRYSVGGHTPGLVRDADGGLTLYVQHKRPANADHSANWLPAPDGPFAVVLRIHGPEASVLDGRWQPPPLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWU6</accession>
    <name>A0A1E7MWU6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6557"/>
    <dbReference type="EnsemblBacteria" id="OEV32915">
        <property type="protein sequence ID" value="OEV32915"/>
        <property type="gene ID" value="HS99_0013605"/>
    </dbReference>
    <dbReference type="OMA" id="KQSDMKA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="454"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="59428" checksum="59AA2F640C504A15" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWZ3</accession>
    <name>A0A1E7MWZ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366910.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000916.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5765"/>
    <dbReference type="EnsemblBacteria" id="ARF81360">
        <property type="protein sequence ID" value="ARF81360"/>
        <property type="gene ID" value="B6264_22805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32950">
        <property type="protein sequence ID" value="OEV32950"/>
        <property type="gene ID" value="HS99_0013780"/>
    </dbReference>
    <dbReference type="OMA" id="HLIYTEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="14992" checksum="AFF6FCADDA15B2B8" modified="2017-01-18" version="1">MTRLAARMGERVQRRVRAMGVGTDPRGIVEAVLLEGVPTDEESRAFHLIYTEYAVLSVTDPALAGQAFLAAPDEMEAFLATQLTAAQRAGTADPRLDARQEAVVLLAVSAGLGLSVLLGQRTADEATAVLHYHLGRVFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX86</accession>
    <name>A0A1E7MX86_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279779.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5649"/>
    <dbReference type="EnsemblBacteria" id="ARF81461">
        <property type="protein sequence ID" value="ARF81461"/>
        <property type="gene ID" value="B6264_23385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33047">
        <property type="protein sequence ID" value="OEV33047"/>
        <property type="gene ID" value="HS99_0014355"/>
    </dbReference>
    <dbReference type="OMA" id="RREPHEE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="192" mass="20574" checksum="87FC8BE083203701" modified="2017-01-18" version="1">MTQQATPARPAPRSRLRRVLPLLITAWLVLEIWLLVLVGSWLGGFAVLLLLVVGGLTGGSLIKRAGLKALSAAIEQSKNPQSQQRQTGTSMTVLAGLLLIVPGFLSDLVALTLLFPPTRALWRAVGRKVADKAVRSASAVGTDPFADAMRLQEQLRIHRPDGKVIQGEVVDPENGPRGPQGPDTTYRPPING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXA8</accession>
    <name>A0A1E7MXA8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0014590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290631.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000267.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5602"/>
    <dbReference type="EnsemblBacteria" id="OEV33085">
        <property type="protein sequence ID" value="OEV33085"/>
        <property type="gene ID" value="HS99_0014590"/>
    </dbReference>
    <dbReference type="OMA" id="FAQNIWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="43"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="321" mass="34887" checksum="0A2084DB67BEFE57" modified="2017-01-18" version="1">MRGYIAVEEAIAIPGLADRRPPFPMPDNIEPAFLADMAARLPDVMRYRLPDMDANGIALQVLSLTVPGIEAEADPARAVDNARYVNDSLAGIVDAHPGRFAAFAALPLQDPAAAVAELRRSVEGLGFKGALVNDHIQGRYLDDPAFDRVWATLGDLGVPLYLHPGMPPADRWHVLDAHPELDGALWSWQAATGGHAMRVVMSGVFDRHPDATMILGHAGEFLPFQLSRFDSRYATLAVPQRLRREPSRYFGTNVLATTSGVLSPAAIEALVRVLGPDSVLFAADYPYERTSAAVTALERTRLPDADKQKIASGNARRLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXB0</accession>
    <name>A0A1E7MXB0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279770.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5644"/>
    <dbReference type="EnsemblBacteria" id="ARF81466">
        <property type="protein sequence ID" value="ARF81466"/>
        <property type="gene ID" value="B6264_23410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33051">
        <property type="protein sequence ID" value="OEV33051"/>
        <property type="gene ID" value="HS99_0014380"/>
    </dbReference>
    <dbReference type="OMA" id="PVACGGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18696" checksum="A39B8A47879C02EE" modified="2017-01-18" version="1">MESTATKDTGTVEFRITGYAHPDAQALSAEVQQEYVRRYGDPDETVMHPEDFEAPAGLFMIAYLDGRPVACGGWRAKQAGPDGLRDGDAEVKRMFVVPDARGRGLARAVLRRLEETAVEAGRTRFILETGTEQPEAIALYGSEGYAAIRKFGIYKDHAQSICMGKELPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXE0</accession>
    <name>A0A1E7MXE0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="12" type="ORF">HS99_0039580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030062195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000399.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene86"/>
    <dbReference type="EnsemblBacteria" id="ARF80118">
        <property type="protein sequence ID" value="ARF80118"/>
        <property type="gene ID" value="B6264_15395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32903">
        <property type="protein sequence ID" value="OEV32903"/>
        <property type="gene ID" value="HS99_0039580"/>
    </dbReference>
    <dbReference type="OMA" id="KRICGRC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV32903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="90" mass="10185" checksum="1392C5DD066E5B2F" modified="2017-01-18" version="1">MSELFELLIGDGIAEDEEELGWQERALCAQTDPESFFPEKGGSTREAKKVCLACEVRSECLEYALANDERFGIWGGLSERERRRLKKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXL1</accession>
    <name>A0A1E7MXL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366517.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene9"/>
    <dbReference type="EnsemblBacteria" id="ARF78128">
        <property type="protein sequence ID" value="ARF78128"/>
        <property type="gene ID" value="B6264_03640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33178">
        <property type="protein sequence ID" value="OEV33178"/>
        <property type="gene ID" value="HS99_0039445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="29619" checksum="F22D58A0F5D1F559" modified="2017-01-18" version="1">MLPRTVRGAVAAAAVVVEEVGKRVADTAAAVLEKTGVDVSEVERKLGGQFPPSAKALQTLAEEAVTAGRAGVDLAVGVARSEVEKAFEKVGDQVTKVGVVLAYLESKLREVEEEPAATKPAPNPYVAPYPEDAPAPAPRADDLFGRGWEFEDERVATEPPVAERVEVDEPVEVDPPLSPKTEAALREAVAEVAEDPAAGKKGAPVTGTEEAPVSGTEGAPAAKKAAARKTAVAKKATVKKSAAARRKQPERNGAEPKAAAKRTATKKTTVRKATSAKKPDVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXM7</accession>
    <name>A0A1E7MXM7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000075">
        <property type="protein sequence ID" value="OEV33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033355582.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000095_gene10"/>
    <dbReference type="EnsemblBacteria" id="ARF78127">
        <property type="protein sequence ID" value="ARF78127"/>
        <property type="gene ID" value="B6264_03635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33179">
        <property type="protein sequence ID" value="OEV33179"/>
        <property type="gene ID" value="HS99_0039450"/>
    </dbReference>
    <dbReference type="OMA" id="YEDVHAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="6961" checksum="A02B38C98FEE866F" modified="2017-01-18" version="1">MSGTSEGGARAETVEPLGVELLPTGHPGVDAGLARLDALDGVPAEAHVAVYEDVHQRLADTLAALDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY11</accession>
    <name>A0A1E7MY11_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0012065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000182.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000070_gene7036"/>
    <dbReference type="EnsemblBacteria" id="ARF80428">
        <property type="protein sequence ID" value="ARF80428"/>
        <property type="gene ID" value="B6264_17295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33327">
        <property type="protein sequence ID" value="OEV33327"/>
        <property type="gene ID" value="HS99_0012065"/>
    </dbReference>
    <dbReference type="OMA" id="IQRNFTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="479" mass="48195" checksum="3CA493F86D344B29" modified="2017-01-18" version="1">MTDLQIRPGVAGGTTGAPAVRPGLLLALVLCGQFMAVLDGSIVNVAVPTIRTDLGASGAALQLVIAGYTISYAVLLITGARLGARYGFSRLFQLGLAGFTATSLACGLAPTTGWLIAFRLLQGAGAALMVPQVMSLLQRTFTGAARTRAIGLYSAVLAVGVAFGQVLGGVLVSADLFGTGWRPVFLVNVPIGLVLLAAGARLLPKLPGDASRGFDVPGLVVLGAALGLLVVPLVLGNELGWPVWGWAMIAAGVLLSGLFVVVERGVARRGGQPLIPGRVLRAPGLRPAAVGLFTIMAAYAGFMFAFALHQQAALGHSALRAGLCSAPVAIAFGLASLRWHRLPGRLHALLPSVAGLLLGGGYLLLGVLLGDGAGIGVVVLAETAALGLAAGSAYAPLFARALAGVAPEDAADASGMTVTVLQLGQVIGVAVLGSVFLGQVDLPAPAADSGHALLITLAVNAAVVLVGAGFAERSRRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY83</accession>
    <name>A0A1E7MY83_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553469.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4014"/>
    <dbReference type="EnsemblBacteria" id="ARF80481">
        <property type="protein sequence ID" value="ARF80481"/>
        <property type="gene ID" value="B6264_17590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33379">
        <property type="protein sequence ID" value="OEV33379"/>
        <property type="gene ID" value="HS99_0012365"/>
    </dbReference>
    <dbReference type="OMA" id="HEYPQAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="203" mass="21533" checksum="F6EEE9B9487408CB" modified="2017-01-18" version="1">MSSPAALGLPTRLDGDPDRVALVIPGAGYSPARPLLHFAGSVLQRHGWTVQELWWHVPDAFREFTTDDRIDWVERQVAEAVDAEHGACRLLVGKSLGSFAAGLAADRNLAAAWLTPVLTLDHVTRALHRACAPTLLIGGSADDLWSRTVADSTGHQVLELPAADHGLELPHDPVGSVDTLREVVARLDGFIGSLAPGDGPTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV0</accession>
    <name>A0A1E7MYV0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555551.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6610"/>
    <dbReference type="EnsemblBacteria" id="ARF82900">
        <property type="protein sequence ID" value="ARF82900"/>
        <property type="gene ID" value="B6264_18145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33599">
        <property type="protein sequence ID" value="OEV33599"/>
        <property type="gene ID" value="HS99_0012925"/>
    </dbReference>
    <dbReference type="OMA" id="FLRQWVR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="235" mass="24670" checksum="9EDA3A8F741589E8" modified="2017-01-18" version="1">MTTEAQEQGAPLVVVASADAVLRHPEAGEHLLTEIERGRAARFRQESGRTDFVAGHVLVRLCAARLLGVPAAALVLAQECPDCGLADHGRPYLPDHPGVQVSLSHTRGVVAAGAGHQPVGVDVELAARGGSLGAVARRVLAPAELALVEAAAEPDRAFLRQWVRKESLIKIGRATLDTLGRIDMSALPLDVPAGAPLRSRFEDLHLLDWTAPEHGAAVAAVSTARPRIVELVPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYV7</accession>
    <name>A0A1E7MYV7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0013250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5198"/>
    <dbReference type="EnsemblBacteria" id="OEV33609">
        <property type="protein sequence ID" value="OEV33609"/>
        <property type="gene ID" value="HS99_0013250"/>
    </dbReference>
    <dbReference type="OMA" id="WPASFPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="319" mass="33789" checksum="C0EA5A4B6EBEEC0F" modified="2017-01-18" version="1">MRHWGPDARGGNTWRRGLVIALLALLTAVLLAFHAEMPNSVGNLGSLLETFLPWVGLAVPVLLVPALLRRSATALLALLVPAVLWANLFGGLVSDKSGGTGDWTVVTHNVEAGNTDVPGTIRGLVASDAQIVALQELAGNQLRSYETGLAGAYPHHTVEGTVGLWSKYPIGEVSPVDLKIGWTRAFRARVTTPQGPVAVYVAHLPSVRLKAESGFTAHQRDVSAQALGDAIQAEPVKKVLLLGDLNGTMNDRSLAPVTSQMRSAQGAAGDGFGFSWPAAFPMARIDQIMSKGGLKPVDSRTLPRDGSDHLAVAATYRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYW0</accession>
    <name>A0A1E7MYW0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0038520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1102"/>
    <dbReference type="EnsemblBacteria" id="OEV33635">
        <property type="protein sequence ID" value="OEV33635"/>
        <property type="gene ID" value="HS99_0038520"/>
    </dbReference>
    <dbReference type="OMA" id="TRILMSM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="494" mass="51448" checksum="CA84131D30F1872E" modified="2017-01-18" version="1">MASNTFGARLLRRKPVSTLIAESEGHGLPAGAPEEGGRSGIHLRRSIGLWQLSAIGIGATIGTGIFFVLGSAVPQAGPAVILSFVVAAVTAGLTALCYAEMASAIPVSGSSYSYAYATLGEGVAFGVGICLLMEYGVSASAIAVSWAEYLNKFLDLAFGLRIPEQLSGAPGGGHWFNLPALLLVAMVCFLLVRGVSESAKVNAAMVGIKIVILLLFIGVALTGFKSGNLTPFMPLGIGGVQMAASSIFFSFIGMDAVSTAGEEVKNPRRTLPMAIIISLVVVTLLYILVALAGIGAQPWTEFGGQEAGLAQIMQNITGQSWPAMIFAVGAIISIFSVTLVVIYGQTRILYSMGRDGMLPKRFAQLSPRTGTPVWNTLVVGVGVGALAAFIPLDVLADITSLGTLIAFSVVSIGVIVLRRTQPDLPRGFKVPGYPVVPLLSVGFCIYLITGLHADTFRAGAIALAVAVAVYFGYSIKHSRLERAEQPVPVDTNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYX6</accession>
    <name>A0A1E7MYX6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000064">
        <property type="protein sequence ID" value="OEV33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290182.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000417.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000105_gene6308"/>
    <dbReference type="EnsemblBacteria" id="OEV33621">
        <property type="protein sequence ID" value="OEV33621"/>
        <property type="gene ID" value="HS99_0038655"/>
    </dbReference>
    <dbReference type="OMA" id="ATREWHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14360" checksum="9B5D6A22A43BAFC6" modified="2017-01-18" version="1">MEIVSSTGLDGLPWPELLPDRSPVLVFPAHPARLPVPEDGWAGCDAARTFPAAPQPGWSAVMTGTRLTIHRPGGAIWFDGEITATREWHRRLRDQHTLLLITGAFTSAFDLRPAAAAGRLLLLTAPVGHTDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYZ6</accession>
    <name>A0A1E7MYZ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366609.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1086"/>
    <dbReference type="EnsemblBacteria" id="OEV33649">
        <property type="protein sequence ID" value="OEV33649"/>
        <property type="gene ID" value="HS99_0038605"/>
    </dbReference>
    <dbReference type="OMA" id="VGWYMAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="46487" checksum="A17C33FDA9C05ADA" modified="2017-01-18" version="1">MDAEGAWRVGQLRRAAAAALIGTAIEFYDFFLYGTAAALVFGPVFFPELGTVGALLAAFSVYAVAFLARPLGAVVFGHFGDRVGRKATLVVSLLLMGLATAAVGLLPGFAVWGWWSPALLVVLRVCQGVGLGGEWGGAALLIAENAPAGRRGRYGGFLQLGPSAGFVLANGGFLALQLVLDERSFREWGWRVPFLASLVLVAVGLFVRLRLAESPLFRADVRRDRPPVVEVLREHWRPVLAGGGAITVGYALFYLTTTYALAYATSGLGVASTLVLAMLLAGAAGGAVTVWLSASHSDRWGRRRTLRWATGLAAGWSLVLFPLLETVRRPLMFLGLAGAMVVLGCLMGPLAAFLPELFPTRVRYTGAALTYNLGGVVGGATTPLVATRLTAAYGTAQPAGWYLAALGVLALGCLWVLPDTTGAELAAVDGGYRRAPVLGADPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ21</accession>
    <name>A0A1E7MZ21_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000061">
        <property type="protein sequence ID" value="OEV33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366784.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000421.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000060_gene4301"/>
    <dbReference type="EnsemblBacteria" id="ARF80344">
        <property type="protein sequence ID" value="ARF80344"/>
        <property type="gene ID" value="B6264_16780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33682">
        <property type="protein sequence ID" value="OEV33682"/>
        <property type="gene ID" value="HS99_0038310"/>
    </dbReference>
    <dbReference type="OMA" id="FGAWGMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="577" mass="60931" checksum="B7F737F94992DB32" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ75</accession>
    <name>A0A1E7MZ75_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="11" type="ORF">HS99_0037970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554884.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000572.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7712"/>
    <dbReference type="EnsemblBacteria" id="ARF78578">
        <property type="protein sequence ID" value="ARF78578"/>
        <property type="gene ID" value="B6264_06305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33734">
        <property type="protein sequence ID" value="OEV33734"/>
        <property type="gene ID" value="HS99_0037970"/>
    </dbReference>
    <dbReference type="OMA" id="AFTTHTG"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OEV33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="198" mass="22226" checksum="0C48741E8C3C8B8C" modified="2017-01-18" version="1">MEKFTTHTGRAVPLCRSNVDTDQIIPAHWLKKVTRSGFEDGLFEAWRKDESFILNRPERRGATVLVAGPEFGTGSSREHAVWALQNYGFHAVISSRFADIFRGNSLKNGLLTVVLPQETVERLWSLTESDPSAEITVDLEKREVRAEGVTASFELDDNVRWRLLNGLDDISITLQNEADIAAFEATRPAFKPRTLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ87</accession>
    <name>A0A1E7MZ87_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">16S rRNA (Guanine(966)-N(2))-methyltransferase RsmD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7697"/>
    <dbReference type="EnsemblBacteria" id="ARF78562">
        <property type="protein sequence ID" value="ARF78562"/>
        <property type="gene ID" value="B6264_06220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33748">
        <property type="protein sequence ID" value="OEV33748"/>
        <property type="gene ID" value="HS99_0038050"/>
    </dbReference>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="194" mass="20744" checksum="5F2401B5C36F4AB4" modified="2017-01-18" version="1">MTRVIAGSAGGRRLAVPPGRGTRPTSDKAREAMFSTLEAFRGTLHGARMLDLFGGSGAVGLEALSRGAEHVLLVEADGQAARVIRENVRTIGLPGAEVRAAKAEKVIAGPPPQTPYDLVFLDPPYAVTDEELREMLITLSAGGWLAEDALVTVERSTRGGEFGWPEGFEVLRSRRYGEGTLWYGRAAAEASDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZA7</accession>
    <name>A0A1E7MZA7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0037785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3782"/>
    <dbReference type="EnsemblBacteria" id="OEV33766">
        <property type="protein sequence ID" value="OEV33766"/>
        <property type="gene ID" value="HS99_0037785"/>
    </dbReference>
    <dbReference type="OMA" id="YPQVNDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008475">
        <property type="entry name" value="PLipase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05506">
        <property type="entry name" value="DUF756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198682" evidence="3">
        <location>
            <begin position="36"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="5">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DUF756" evidence="4">
        <location>
            <begin position="334"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="490" mass="49288" checksum="F94AB91CF85D62D5" modified="2017-01-18" version="1">MFKRQGRSLSRITTVMLTTSLALGGGLFAAGAAAAADTPASGVTKAVIQSSMVSEKVDVAGKGTVDAGLFTLKTSDGGLLQTYCIDFDNPVYLDSGAQYHEADWAASSLGANAKAPMIRWILDNSYPHVNLTALAAAIKVDSLTAEDAAAGTQAAIWKFSDNKSVTLHKTNATKLRDYLVSDSNKGIAAEPKPSLTLSPDSVSGKSGGKIGPFTLNSSAAEVKLSIGGPAADKAKLVDKDGKPVGATLTGPIAKDTQLFLDVPGGTPDGAVTLNANASTVVPSGRVFMTDVDDDGNHSQTMILASSDKLSVNAAAKATWKQGKGALVDSSAKVECAKNGVTVSVTNSGDEAATVTVDKQQVTVQPGKTESVLVKVAEKAKYDIKVSGPNGYTKEFTGVLDCKVGVTPSSAPSTPAATGSATATPSGTPSTGAAHPAPSTTSAAPGTGGLAQTGANSNTPLLAGIAGALVVAGGAAVFFLRRRGRHGGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZI5</accession>
    <name>A0A1E7MZI5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0037545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290394.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4397"/>
    <dbReference type="EnsemblBacteria" id="ARF80314">
        <property type="protein sequence ID" value="ARF80314"/>
        <property type="gene ID" value="B6264_16625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33844">
        <property type="protein sequence ID" value="OEV33844"/>
        <property type="gene ID" value="HS99_0037545"/>
    </dbReference>
    <dbReference type="OMA" id="IAHDFAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26615" checksum="B725958F2C0DF9C0" modified="2017-01-18" version="1">MTAVLVAAGAFLMTLIGGFVAQRTGDRRHLVLGFAAGLMLGVVAFDLLPEAIHQAPGEVHGVPQALLMFAGGFLTIHVIERAVAIHRGHEGEYAEHTHGGHHHGHAHHSGHQGIGLTAALALVGHSVMDGFAIGAAFQAGTTVGTVVAIAVVAHDFADGFNTYTITRLYGNNRRRALTLLAADALAPVSGAAITLAFTIPEHLLGLYLGFFSGFLLYLATSDILPEAHSPHPSRSTLLCTLAGVGFMWLVIGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZP5</accession>
    <name>A0A1E7MZP5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0010525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552243.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000363.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1843"/>
    <dbReference type="EnsemblBacteria" id="OEV33909">
        <property type="protein sequence ID" value="OEV33909"/>
        <property type="gene ID" value="HS99_0010525"/>
    </dbReference>
    <dbReference type="OMA" id="WNTGGCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="54510" checksum="FB15C9194CF04AFD" modified="2017-01-18" version="1">MRVAVIGSGFGGLGAAVRLRRAGITDFVVLERADSVGGTWRDNSYPGCACDVPSHLYSFSFAPNPYWPRSFSGQPDIRAYLEKVATVFGLRPHLRFNTEVLEARWESEQIRWRITTSAGQWTADAVVSAAGPLADPQIPDLPGLSTFPGKVFHSSRWDHDYDLTGKRVAVVGTGASAAQIIPSIQPKAGKLTVFQRTPAWVLPRRDREITQLEKWLHGRLPVTAKIRRGTLFALREIQVDAFVRRPGLLRLVQRLAERHIAQGIADPALRAKLTPDYRIGCKRILLSNTYYPALAAANTEVVSSGLRELHGSTLVAADGSEHEVDAIVFGTGFHVTDMPIGARVFGVNGTSLAEEWKDGMEALRGSTVHGFPNLFFVIGPNTGLGNSSMILMIESQLNYMIDALTTLHSVGAAAIQPTVRAQRQWNLELQHRMDRTVWTTGGCRSWYLDPSGRNTVLWPGSTTSFRRATRKVDLGEYELIMATAPTAARTVQEANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZY2</accession>
    <name>A0A1E7MZY2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551750.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000411.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2238"/>
    <dbReference type="EnsemblBacteria" id="ARF77857">
        <property type="protein sequence ID" value="ARF77857"/>
        <property type="gene ID" value="B6264_01995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34000">
        <property type="protein sequence ID" value="OEV34000"/>
        <property type="gene ID" value="HS99_0011150"/>
    </dbReference>
    <dbReference type="OMA" id="WHMRMAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="156" mass="16858" checksum="54F470BA008FA0B8" modified="2017-01-18" version="1">MSIRDDAAEVRSSGWRTLAALHGLIDAALEKALQAEHKLSVVEYTVLEALSRQDGWHMRMQQLARAAALSSSATTRLVSRLEDRGLLGRYLCADDRRGIYTELTPAGRALLEAARPVHDATLEATLTQAAELPELAPLVDALAELAPAKAQPPVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZY4</accession>
    <name>A0A1E7MZY4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2232"/>
    <dbReference type="EnsemblBacteria" id="OEV33994">
        <property type="protein sequence ID" value="OEV33994"/>
        <property type="gene ID" value="HS99_0011120"/>
    </dbReference>
    <dbReference type="OMA" id="NDERQMF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="38231" checksum="67291527016B5850" modified="2017-01-18" version="1">MSTQGQFPGAAGESERTRRLRSLGLNEPSADEAFDRFAHLAASITRAPIAMVNFINDERQMFRGLYIPPNTAEVAAEEGASWADRGIAFDLPTRQMPMSHGFCPHVVAQRSPLALDDILAYPRFAGNPVVDELGVRAYLGAPLVDDTNTVIGTVCVLDREPRQWGRERLRDIQHLAEALLSEIRLRDNLLAQQQEMFAAFDGSPFPIMLTDGPGQEIRYANAQHADTFGPPVAYGSIGTAYPQLGAAGLQQAVSEAYHTGRATVLNDVRIQSGRPEVQRIQQIFSFTCTPLRVARTGQVNGVLTVGMDVTAQSRTEEELGTLAALLVDRLQQNGAVTPTARPGAAGGSGLVLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N017</accession>
    <name>A0A1E7N017_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease subunit gamma</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0011295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urease gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280142.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2270"/>
    <dbReference type="EnsemblBacteria" id="ARF77881">
        <property type="protein sequence ID" value="ARF77881"/>
        <property type="gene ID" value="B6264_02145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34024">
        <property type="protein sequence ID" value="OEV34024"/>
        <property type="gene ID" value="HS99_0011295"/>
    </dbReference>
    <dbReference type="OMA" id="MNLAPRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="101" mass="11126" checksum="FEE194EB786177F4" modified="2017-01-18" version="1">MNLSPREMDKLYIYVVADLARKRRDRGVRLNYSEACALISEAIMEGARDGRTVAECMEIGKQVVSNADVMPGVREMLPLLQVEAAFLDGTKLVSCHDPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N037</accession>
    <name>A0A1E7N037_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280099.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2294"/>
    <dbReference type="EnsemblBacteria" id="ARF77901">
        <property type="protein sequence ID" value="ARF77901"/>
        <property type="gene ID" value="B6264_02265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34044">
        <property type="protein sequence ID" value="OEV34044"/>
        <property type="gene ID" value="HS99_0011415"/>
    </dbReference>
    <dbReference type="OMA" id="IAGYCPT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="378" mass="39892" checksum="D5BC1889CC57EB12" modified="2017-01-18" version="1">MTTAPLRVLVHGGGIGGLTLATALARRGHHVEVAELRDRLEALGVGIIQPSNALHVMREIGVLDECLAVGFGWEVLTICDPAGTTLAQIPQPRMGDAPSNNGIPRPALARVLAAAATSAGATIRFGTSISELTDDGSGVDVTLTDGHGGRYDLVVGFDGIGSPLRRHLYGEKYAPEYTGFANWRVTLPRSPEVKGVVMSAGNLRAKALLTPISEELMYLGSVFAEAEDFRPDPATAHEQLRERLAGFGGPIAEALAQVTDPAAVVYSRISQVTVEEPWHVGRVVLAGDAAHASTPHLAQGAAMAVEDALVLAESLEAGSDVPAALAVWEERRRPRAMWVQAMSRAILKQETGSPTTAEEDELLKIGIPGAAHVLVKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N066</accession>
    <name>A0A1E7N066_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386596.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000422.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2313"/>
    <dbReference type="EnsemblBacteria" id="ARF77918">
        <property type="protein sequence ID" value="ARF77918"/>
        <property type="gene ID" value="B6264_02365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34061">
        <property type="protein sequence ID" value="OEV34061"/>
        <property type="gene ID" value="HS99_0011515"/>
    </dbReference>
    <dbReference type="OMA" id="GWITETE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="97" mass="10804" checksum="B62B9FAAFD0D2CF6" modified="2017-01-18" version="1">MRQRYSFHLDRSGHSVTVNVRSGWITETELLVDGKECAFHRVHGHGSYPLTLSGQFAEEPPCPLSVRLDRTGLPEHPLTCVLELAGAEHPMPESTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0J0</accession>
    <name>A0A1E7N0J0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000053">
        <property type="protein sequence ID" value="OEV34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1974"/>
    <dbReference type="EnsemblBacteria" id="ARF79580">
        <property type="protein sequence ID" value="ARF79580"/>
        <property type="gene ID" value="B6264_12235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34194">
        <property type="protein sequence ID" value="OEV34194"/>
        <property type="gene ID" value="HS99_0037085"/>
    </dbReference>
    <dbReference type="OMA" id="QYRWINH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="762" mass="80519" checksum="55C5121214FE79EC" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0R1</accession>
    <name>A0A1E7N0R1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6071"/>
    <dbReference type="EnsemblBacteria" id="OEV34261">
        <property type="protein sequence ID" value="OEV34261"/>
        <property type="gene ID" value="HS99_0036940"/>
    </dbReference>
    <dbReference type="OMA" id="VWIHGLT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="242"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="328" mass="35700" checksum="1B1783B006A30AAC" modified="2017-01-18" version="1">MQPETYGAPRTAPVPAQRSAAPAEGFAVVDVETTGLGRSDRVISAGVYQLDHDGEVTDHWYTLVNPERDPGPVWIHGLTAELLSGAPTFPEIADEFAARLENRVLVAHNALFDWNMISREFSRAGRRAPVEQRVCTMVLSRDLRLPLPNGKLASLAAHFGVQQRHAHNALDDARVLAEAFRPSLQLARLAGVPLPLQTCVAVTDLGEEEPATPGRSNWTGSQYRQAKKRPPCPYPNPGRWEDGKPLVQGMRVAFTGDTATDREVLEDRAVEAGLHIATSVSRLTSLLVTNEPASWSGKARKARDVGTPVVTEDAFLQLLREVAPHPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T5</accession>
    <name>A0A1E7N0T5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0011635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551868.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000956.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2338"/>
    <dbReference type="EnsemblBacteria" id="ARF77942">
        <property type="protein sequence ID" value="ARF77942"/>
        <property type="gene ID" value="B6264_02490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34083">
        <property type="protein sequence ID" value="OEV34083"/>
        <property type="gene ID" value="HS99_0011635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="8528" checksum="C48DBF9C2DF89B34" modified="2017-01-18" version="1">MSRHRIPVAPTDPGMHDYTAPQTTTLLGELHRRGLPYGLLRGSAAPGETTLDGRTLVDFGHAPVSTLLNLRDLEGDEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0W6</accession>
    <name>A0A1E7N0W6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0036350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6402"/>
    <dbReference type="EnsemblBacteria" id="OEV34322">
        <property type="protein sequence ID" value="OEV34322"/>
        <property type="gene ID" value="HS99_0036350"/>
    </dbReference>
    <dbReference type="OMA" id="ICAVANN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="517" mass="53687" checksum="3E4154B352BFCA94" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0X0</accession>
    <name>A0A1E7N0X0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0036365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000049">
        <property type="protein sequence ID" value="OEV34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366576.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6405"/>
    <dbReference type="EnsemblBacteria" id="ARF78728">
        <property type="protein sequence ID" value="ARF78728"/>
        <property type="gene ID" value="B6264_07170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34325">
        <property type="protein sequence ID" value="OEV34325"/>
        <property type="gene ID" value="HS99_0036365"/>
    </dbReference>
    <dbReference type="OMA" id="THVAMYL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015063947" evidence="3">
        <location>
            <begin position="44"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="511" mass="51761" checksum="F59DF41E82EB27AB" modified="2017-01-18" version="1">MGGAAQRTETSGVRPWVRAALRCGAVLAAAALALPLATQAAYAAPDPGAGTAVAPGADPLAAAKATLGPLLDQLHGLYQSAEAATEQYNGAVAKVTEQQAALTDLQGRLDRQQKQVDAGTDIASQLAAAQYRNGAASAYAELLLSKDPYEAVTIAELLQAASRSQSEFLDRLKADREALDALKKQTEDALRTSQALVVQQDAAKAKVAADLASVEQLVSSLTGAQRAELEQLEKAKADEAQLAFLASGALGKGERTPSLSGRAAVAFALAQLGKPYLWGGTGPDSYDCSGLTSQAWLHAGKPIPRTSQEQWAQLPHVPLNQLRPGDLVIYFQDASHVAMYIGGGLIVQAPRPGAFIKVSPIGSMAILGAVRPDPDGAADDAGGAWKVPDLPKGWDSVTPITPSRPPAPPATQQPTGTPATPSGTPSGTGTPSNPSGTGTPSGTGTPSGTGTPTDKPTGAPTQTPTQSPTQTPTNTPTGTPTGTGTPSTTGSSSASAPGSPTATLPLGGLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N130</accession>
    <name>A0A1E7N130_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3910"/>
    <dbReference type="EnsemblBacteria" id="OEV34386">
        <property type="protein sequence ID" value="OEV34386"/>
        <property type="gene ID" value="HS99_0036160"/>
    </dbReference>
    <dbReference type="OMA" id="MVPNYNP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="407" mass="42432" checksum="3B4B28047B0B4E22" modified="2017-01-18" version="1">MRGEGLHLYDADGRRYLDFTSGVGVTSTGHCHPKVVEAVREQAGRLLHGQYTTVLHDQLLTLTERLGDFLPPGLDSLFYATAGTEAVEAALRLARHATGRQNVIVFEGSFHGRTMGAASLTTAGTRFRAGIGPLVPGVAVAPFPAAFRLGLSQEEAVAHALHGLDEVLATVSAPAETAAVFVEPVLGEGGYVPAPAGFLAGLRERADRHGILLVLDEVQTGFGRTGRFWAHQHEPEVVPDVLITAKGLASGFPLSAIAAPTELMKRAWPGSQGGTYGGNPVACAAALATLDVLREERLVENAAEQGARLLDGLRAVAAGAPGIGDVRGLGLMAASEFCRPDGSPDQDTARRVQQAAADLGLLLLTCGIHLNVVRMIPALVVTAAQIDEALALWSKAVAAGARPEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N135</accession>
    <name>A0A1E7N135_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein regulation protein LC7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289775.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000234.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1425"/>
    <dbReference type="EnsemblBacteria" id="ARF79228">
        <property type="protein sequence ID" value="ARF79228"/>
        <property type="gene ID" value="B6264_10150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34409">
        <property type="protein sequence ID" value="OEV34409"/>
        <property type="gene ID" value="HS99_0035970"/>
    </dbReference>
    <dbReference type="OMA" id="RQNMTEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="137" mass="13981" checksum="DA95F429C3291EBE" modified="2017-01-18" version="1">MTTTPDLGWLLADIIAVPQVQHAVVVSNDGLEIGRSADIAREDAERLAAACSGLQSLARGVAAGFGGPGSATRQIIIEYGGGYLFIVAAGAGAHLAVVTSEAVDAGLVAYQMQVLVERIGTHLTSPPRVDHAAGGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N148</accession>
    <name>A0A1E7N148_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0036025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289787.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1413"/>
    <dbReference type="EnsemblBacteria" id="ARF79236">
        <property type="protein sequence ID" value="ARF79236"/>
        <property type="gene ID" value="B6264_10205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34418">
        <property type="protein sequence ID" value="OEV34418"/>
        <property type="gene ID" value="HS99_0036025"/>
    </dbReference>
    <dbReference type="OMA" id="VLHDIFA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="298" mass="31897" checksum="AF48E1D0304E5491" modified="2017-01-18" version="1">MSGDISRAELLAAQFEAERPQLRSLAYRMLGSVAEAEDAVQEAWLKLSRSDVGEVRNLGAWLTTVVGRVCLDQLRSRASRREDPLPEQEEQVRLPDPVVTGPAVLDPVHEILVADSVGIALMVVLETLSPAERVAFVLHDMFDVPFDGIAEVLGRTPASTRQLASRARRRVQGATPAADSDDDRKRAVVEAFLSASRGGDFDALLAVLDPEVLARSDGGTLVPSVLRRGAADVAGQAITFARFAAEARLVLVNGSPGVVSFADGRVLSVMSFTIHEDRITGLDILTDPTRLAALGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1M3</accession>
    <name>A0A1E7N1M3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0036245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000048">
        <property type="protein sequence ID" value="OEV34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366389.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3927"/>
    <dbReference type="EnsemblBacteria" id="OEV34373">
        <property type="protein sequence ID" value="OEV34373"/>
        <property type="gene ID" value="HS99_0036245"/>
    </dbReference>
    <dbReference type="OMA" id="GRSCIGY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="49507" checksum="3CC27DEB1D011BEE" modified="2017-01-18" version="1">MTTQYHPTAQYTSVTAPGALPLLGHAPAFIRSPLDFVAGLAAHGDLVRLRLGPLDAYVACHPDLVRRLLTEDRTYDKGGIIIEKAREAFGNGLATCPARAHRRQRRMLQPAFHRDRLPGYAAMMAEEIAGATARWRDGDVVDVPAAMYRLSTAVTARCLFAAHERAGTLPVHDSMDVVTRGVARRMMLPLPGADRIPTPGNRRFERARQNLREITRLLIADYRAAGTDHQDLLSVLLSARDEHGRGLSDGEIHDQVVTFLLAGMETSAATLSWAWTLLAANPAVRERLHTELDTVLDGRPARHEDLPALPLTARIVNETLRLYPPAWILSRTVTADTELGGHRLPAGATVLYSPYLLHRRADLFPCPDRFDPDRWLTTARPAPGTYTPFGLGARRCIGEAFGTTEAALALATIAARWTVTPTRGRPIRPHRSSSLSPRSFTATLNRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1N4</accession>
    <name>A0A1E7N1N4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0035280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552810.1">
        <property type="nucleotide sequence ID" value="NZ_JOER01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5572"/>
    <dbReference type="EnsemblBacteria" id="ARF82751">
        <property type="protein sequence ID" value="ARF82751"/>
        <property type="gene ID" value="B6264_10810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34576">
        <property type="protein sequence ID" value="OEV34576"/>
        <property type="gene ID" value="HS99_0035280"/>
    </dbReference>
    <dbReference type="OMA" id="VPRHRFI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="372" mass="40368" checksum="4677B9581B8F8AB5" modified="2017-01-18" version="1">MANGSLTSDWLASYNAVPRHWFVPDTTWPGQADGVRQGEAVSRQADPAAWWSAVYSDVPLTTQWDDGTHTGDSRGTMPTSSNSMPTMVFSMLDALDVAEDNRVLEIGTGTGWNAALLAHRVGPGNVVTVEVDEGSATDAQGRLARAGYSPTLVVADGAEGYAKAAPYDRVIATCSVGRVPYAWVEQSRPGGVIVAPWGPEYGGEAVARLTVGDDGTATGRFIGSSAFMRLRQQRTPRPDSLTYLSAPWPAGGARFRSSLSPDDVGGWLEMFSIGVQVPGAFPLTERYPDGTYTLWLHDTAVTSWATADWEPDRTDYEVVQSGPRNLWDEVEAAWRWWDDQGRPGFDRFGLTVTADSHAVWLDSPDNPVPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1P6</accession>
    <name>A0A1E7N1P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0035875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000047">
        <property type="protein sequence ID" value="OEV34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557806.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7195"/>
    <dbReference type="EnsemblBacteria" id="ARF79214">
        <property type="protein sequence ID" value="ARF79214"/>
        <property type="gene ID" value="B6264_10055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34393">
        <property type="protein sequence ID" value="OEV34393"/>
        <property type="gene ID" value="HS99_0035875"/>
    </dbReference>
    <dbReference type="OMA" id="MVPARVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="727" mass="75541" checksum="C106B47031A12081" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N256</accession>
    <name>A0A1E7N256_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557010.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000163.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81848">
        <property type="protein sequence ID" value="ARF81848"/>
        <property type="gene ID" value="B6264_25795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34790">
        <property type="protein sequence ID" value="OEV34790"/>
        <property type="gene ID" value="HS99_0009950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="91" mass="9895" checksum="6EB7B6B68F68D1A1" modified="2017-01-18" version="1">MSSAFEDFLEIEAEIAPGRRAELSFDHRRRALLVRGPGTAVRAADRLGRVIAQPAAASRPRLRYSHQSVGHRTVEPVGAGSGRMRVHPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q3</accession>
    <name>A0A1E7N2Q3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="1">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="1">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="1">PII uridylyltransferase</shortName>
                <shortName evidence="1">UTase</shortName>
                <ecNumber evidence="1">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="1">UR</shortName>
                <ecNumber evidence="1">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glnD</name>
        <name evidence="2" type="ORF">HS99_0034625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="1"/>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554867.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7681"/>
    <dbReference type="EnsemblBacteria" id="ARF78545">
        <property type="protein sequence ID" value="ARF78545"/>
        <property type="gene ID" value="B6264_06135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34956">
        <property type="protein sequence ID" value="OEV34956"/>
        <property type="gene ID" value="HS99_0034625"/>
    </dbReference>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Uridylyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="832" mass="86724" checksum="01FBE9901EA26186" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2X4</accession>
    <name>A0A1E7N2X4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0034440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552887.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000338.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4713"/>
    <dbReference type="EnsemblBacteria" id="OEV35034">
        <property type="protein sequence ID" value="OEV35034"/>
        <property type="gene ID" value="HS99_0034440"/>
    </dbReference>
    <dbReference type="OMA" id="DIYKIYA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="210"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="321"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="481"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="546" mass="57441" checksum="5BFFA96743DAE0AF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N323</accession>
    <name>A0A1E7N323_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385938.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000168.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000074_gene7605"/>
    <dbReference type="EnsemblBacteria" id="ARF81785">
        <property type="protein sequence ID" value="ARF81785"/>
        <property type="gene ID" value="B6264_25390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34853">
        <property type="protein sequence ID" value="OEV34853"/>
        <property type="gene ID" value="HS99_0010330"/>
    </dbReference>
    <dbReference type="OMA" id="DAGCFAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="30613" checksum="E4942BF81648BC57" modified="2017-01-18" version="1">MHQLLRRSLPALAALGIAVGAPLLTAGAAQAQAEHGCGTVGVQFSVDGGKGWISDGRMSQPHGVIQVRLAGDVVEGCDYRISLASYDTEGPTWATSGKQTFLGWATTTLRSGNRQATLDVSAHLPKCYGQIDLYNGDKKFDGVANPAPRYPDGVYSDNLISAWNGGKACVPTPTGTPTVPVPTSSASPTATATPHPTGTPTATTTPSATATASPSTTAKPSGPATTGTPSSGTPSTTPAVPAPSAPADTTGPVGKPTANPVSTTPDSTLASTGGNSSQMIVYGAGGAALLAVGGGALVIARRRGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3E1</accession>
    <name>A0A1E7N3E1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1388"/>
    <dbReference type="EnsemblBacteria" id="ARF79259">
        <property type="protein sequence ID" value="ARF79259"/>
        <property type="gene ID" value="B6264_10325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35200">
        <property type="protein sequence ID" value="OEV35200"/>
        <property type="gene ID" value="HS99_0033295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="66" mass="6999" checksum="1FC0F0AF35EF9C25" modified="2017-01-18" version="1">MAACTQCSASAVIEDLDVQPPQTWSLGCATARVRAGDPMINYRSLNRDSDYAHILAGGSTQVLPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3P6</accession>
    <name>A0A1E7N3P6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000758.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5327"/>
    <dbReference type="EnsemblBacteria" id="ARF80735">
        <property type="protein sequence ID" value="ARF80735"/>
        <property type="gene ID" value="B6264_19110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35310">
        <property type="protein sequence ID" value="OEV35310"/>
        <property type="gene ID" value="HS99_0033170"/>
    </dbReference>
    <dbReference type="OMA" id="WLTLPDI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="121" mass="13568" checksum="8A99D83DB8AEAAF3" modified="2017-01-18" version="1">MSEIESKIEALVPEWMYLPDISEQWGVLVTEVRNMVKKGELIAVRRGPNKSLQVPAAFIDGPGLVKHLPGTLTVLRDCGYNDVEILEWLFTEDPSLPGSPIQALRENRGTEVKRRAQAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U3</accession>
    <name>A0A1E7N3U3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0032495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386202.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000262.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2440"/>
    <dbReference type="EnsemblBacteria" id="OEV35342">
        <property type="protein sequence ID" value="OEV35342"/>
        <property type="gene ID" value="HS99_0032495"/>
    </dbReference>
    <dbReference type="OMA" id="YVYETRE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="302" mass="32774" checksum="CD18A96181AB49EA" modified="2017-01-18" version="1">MTSGSGGNGGVNGNGDGTGFFTSVADTAERLAATGYLPSTAVATTVFLADRLGKPLLVEGPAGVGKTELAKAVAELGAARLVRLQCYEGIDEARALYEWNHAKQLLRITAGRDEGWDRARDDIFGEEFLLTRPLLTAIRGEEPTVLLIDEMDKADIEVEALLLEVLSDFQVTVPELGTVTATRRPFVLLTSNATRELSEALRRRCLFLHLDYPDAELERRIVRLKVPGLDDTLAASLVRVVGALRAMELRKAPSVAETVDWARTLLALGADSLDETVVRETLGVILKHQDDIRKATQKLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N415</accession>
    <name>A0A1E7N415_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1617"/>
    <dbReference type="EnsemblBacteria" id="OEV35439">
        <property type="protein sequence ID" value="OEV35439"/>
        <property type="gene ID" value="HS99_0032280"/>
    </dbReference>
    <dbReference type="OMA" id="REPAFHG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="276" mass="30485" checksum="3A876C56C75D2DC6" modified="2017-01-18" version="1">MSVADVTTVTRTATPRRFLMCPPRHFDVTYSINPWMNPAKPVDTSLAFAQWTELKNLYESLGHTVEVIEPLPGLPDMVFAANGATVVNGRVLGARFRHVERTAEGPAYLAWFTEHGYTDVLWPEHINEGEGDYLVVGRKVLAGTGFRTDPRSHAEAQEYFGLPVIGLTLVNPEFYHLDTALAVLSENEIMYYPDAFTPGSQEVLRELFPDAILATAEDAAVFGLNALSDGRHVLLPDAAVQLKTRLRERGFEPIGVDLTELLKAGGSVKCCTLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N421</accession>
    <name>A0A1E7N421_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0032270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290461.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1615"/>
    <dbReference type="EnsemblBacteria" id="OEV35437">
        <property type="protein sequence ID" value="OEV35437"/>
        <property type="gene ID" value="HS99_0032270"/>
    </dbReference>
    <dbReference type="OMA" id="WATQTGM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="8">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="22574" checksum="1E41BE801EE9E614" modified="2017-01-18" version="1">MTSSWTGAVRRYALRRLPSEKLIPETQPVYMASWIYVFGVLTVSALVVVLVSGGVLALMGPGWWHVSGVGRYVNSVHLWSVQLFMAVMVIHLWGKFFMAAWRGRRVLTWMTGAVAFLVSLATAFTGYLVQQNFDSQWISGQAKDALNATGIGAWFNVFDFGQMLMWHVLLLPLAIGLLSVWHILLVRVRGIVPPIGATAPGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N452</accession>
    <name>A0A1E7N452_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283414.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3881"/>
    <dbReference type="EnsemblBacteria" id="OEV35452">
        <property type="protein sequence ID" value="OEV35452"/>
        <property type="gene ID" value="HS99_0032350"/>
    </dbReference>
    <dbReference type="OMA" id="PNPYFFE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="260" mass="27356" checksum="86B795BDC1D5B118" modified="2017-01-18" version="1">MPEAAIRAVLLDLEGTLYAQGKAVEGAAAAVQALRESGLALRFLTNTDSKPAARIHDELVDYGLPVRREELFTPVVAAQQLLAAPGTRVYPLVSRALLGELPNLVAEPPYTHALIGDCRDVLDYRALDEAFRAVRGGAELVALQRGRYFKRADGDHLDTGALVAAVEYSAGTTARILGKPAADFFELAARSLGLPPSACVVVGDDAGTDIAGGEAAGLTTVQVRTGKYADQLAEGLTGRAGYECDSVADLPALLTELRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N473</accession>
    <name>A0A1E7N473_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galactosylceramidase</fullName>
            <ecNumber evidence="2">3.2.1.46</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Galactosylceramidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0032175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.46" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000034">
        <property type="protein sequence ID" value="OEV35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000084_gene1595"/>
    <dbReference type="EnsemblBacteria" id="OEV35472">
        <property type="protein sequence ID" value="OEV35472"/>
        <property type="gene ID" value="HS99_0032175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006683">
        <property type="term" value="P:galactosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001286">
        <property type="entry name" value="Glyco_hydro_59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15172">
        <property type="entry name" value="PTHR15172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00850">
        <property type="entry name" value="GLHYDRLASE59"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Ricin B-type lectin" evidence="6">
        <location>
            <begin position="644"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="738" mass="77850" checksum="A2B89E321B6A5772" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4K2</accession>
    <name>A0A1E7N4K2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551206.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene963"/>
    <dbReference type="EnsemblBacteria" id="ARF80815">
        <property type="protein sequence ID" value="ARF80815"/>
        <property type="gene ID" value="B6264_19580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35619">
        <property type="protein sequence ID" value="OEV35619"/>
        <property type="gene ID" value="HS99_0006810"/>
    </dbReference>
    <dbReference type="OMA" id="DRTWQQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="365" mass="39038" checksum="43B5E744CC21CB66" modified="2017-01-18" version="1">MRRALGVVAALALLGGVTYALVPDDGPDPRKTVTVTGLIGSEKRAFFESPEVKAELAKQGLEVHSDSTGSWTMSEQAKSNSGLDFAFPASTAPAREIQRNWGQQDSPLVPFYSPLVVVAHAPVAQVLKDNKLAAQDADSGVWTFRMDEYVNVLRANRRWQDLTNAEGHGDLAGPIYVTTTDPESSSSGALYVALLSYVLNNHQVVSDDAGVEAARPVLHQATAMQGGQKSSSDEPFRDFQAGVGNPLLFGYESQVASLTAQGQSAGDTVVMYPDTTVYSDHTIIARTENGRKLAALLQDDDALRTLEARFGFRPQARPGAFAELVKGSRQPAFAQDLNAARVKQSPVPSLDNLLKLTAAAKGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4L6</accession>
    <name>A0A1E7N4L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281833.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000702.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene944"/>
    <dbReference type="EnsemblBacteria" id="ARF80830">
        <property type="protein sequence ID" value="ARF80830"/>
        <property type="gene ID" value="B6264_19680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35636">
        <property type="protein sequence ID" value="OEV35636"/>
        <property type="gene ID" value="HS99_0006910"/>
    </dbReference>
    <dbReference type="OMA" id="DQRVRPQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="143" mass="15736" checksum="72C76130715A8D3E" modified="2017-01-18" version="1">MTSDTPHPDTLDLAADLRAALGNLVRTLRDSDDLPPNQAAVLGLLIRDERSCTVAELADRRRVRHQSMARTVALMAEAGLVAQQPHPTDGRKQLIAPTNAGRAALLDQRARREHHIATAIETRLSTEERAQLRASVELLQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5M6</accession>
    <name>A0A1E7N5M6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281471.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene770"/>
    <dbReference type="EnsemblBacteria" id="ARF82962">
        <property type="protein sequence ID" value="ARF82962"/>
        <property type="gene ID" value="B6264_20570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35978">
        <property type="protein sequence ID" value="OEV35978"/>
        <property type="gene ID" value="HS99_0007795"/>
    </dbReference>
    <dbReference type="OMA" id="HVIEIHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="233" mass="24719" checksum="39CB9CDD9D8FE419" modified="2017-01-18" version="1">MIRIRGVSKTYDRSDSARPALAGLDLEVRAGEALAVLGRSGSGKSTLLNLIAGLDRPSEGGVEVDGVAVHELGEAALAEYRRTRIGMVFQFFNLLDDLNVEDNVLLPAQLAGMKREQARARAGELLERLGVVRHAKAFPGRLSGGERQRVAVARALMNRPPLLLADEPTGALDTASAADVRDLLRGLNAEGQTILLVTHDNALAEACADRTIELLDGRLVRDTAAAPTSGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5V9</accession>
    <name>A0A1E7N5V9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287513.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000564.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene521"/>
    <dbReference type="EnsemblBacteria" id="ARF78800">
        <property type="protein sequence ID" value="ARF78800"/>
        <property type="gene ID" value="B6264_07615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36034">
        <property type="protein sequence ID" value="OEV36034"/>
        <property type="gene ID" value="HS99_0031510"/>
    </dbReference>
    <dbReference type="OMA" id="FAHGGWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21572" checksum="D2BB22514FEF4DB8" modified="2017-01-18" version="1">MRIVISEFISLDGVVQAPGAPQEDTDGGFAHGGWSHPFFDPETIGPFINEAMSSTDALLFGRRTWRTMAAAWPERAGDPLADRMNSIKKYVVSDTLDEADLTWTNSTLVPGTAAVDWIRGQRAADGGDLLIMGSPTLVRSLLGEDLVDELRLMVMPVLLGGGKSLFPADGVRRTLELVSTTTARTGVHLATYRRATQADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5X9</accession>
    <name>A0A1E7N5X9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551262.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000203.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6345"/>
    <dbReference type="EnsemblBacteria" id="ARF78778">
        <property type="protein sequence ID" value="ARF78778"/>
        <property type="gene ID" value="B6264_07470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36054">
        <property type="protein sequence ID" value="OEV36054"/>
        <property type="gene ID" value="HS99_0031655"/>
    </dbReference>
    <dbReference type="OMA" id="LWGKTGH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="43277" checksum="B83F179750396E88" modified="2017-01-18" version="1">MKPFARRAAALALACSAVVGVTAASGAQAFAASGTGTGSTAATAFPALDPAALQAAIETRPSDNSSGALALVAEPGQVWKGSTVDSQTGRKIPENAHFHAGSISKVFETTVVLQLAAEGRIDLDQTVQHYMPGLLPDTFAPITVRQLVNYTSGLPNVDEGRPPASADETIADRYDYRTFDQIIQQTLRPDDGRPAPGPHFTPGTEQEYNSLGFRIAGKLIEQTTGNSFRDEVTARILKPLHLNQTSVPEDDPEMPRPYLHGYMTDDNGRAVDTSEQGGDPSNIISTTADLDRFLTTLLQGRLLPAAQQNELFTLPKDNEGKLVPFVGGSSCNKVACFGAGLMSTPLPNGTLLWGKTGHDDGYANGMFATRDLSVHAVYSTSNLGLDFGAPTPLANRLLTAVLTPSTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N607</accession>
    <name>A0A1E7N607_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0031155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597239.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="REBASE" id="196449">
        <property type="entry name" value="S.SauDM1ORF15140P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80073">
        <property type="protein sequence ID" value="ARF80073"/>
        <property type="gene ID" value="B6264_15135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36127">
        <property type="protein sequence ID" value="OEV36127"/>
        <property type="gene ID" value="HS99_0031155"/>
    </dbReference>
    <dbReference type="OMA" id="GDICEIQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="212" mass="23029" checksum="D08305A008712B99" modified="2017-01-18" version="1">MTYSAEQPIPADWTTTELGVLCEIQSGPGHLTNPASRSNAGIPLLRPMNIGYRGQIVHADLTFLPQEAESKVDQYRLRPGDIVCARTGDPGRAARITDAEAGWLFSGNLLRLRLRAPEWQGYLLHYLGSPVAKNWFEQASTSTVGIPSVTVAALSKLPVNLPPHAQAAAITEILEGLSEKIAVHEEIARTTAELRDLISPAMFTGAMSPHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N625</accession>
    <name>A0A1E7N625_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="1 2">N5-CAIR synthase</shortName>
            <ecNumber evidence="1 2">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 2">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">purK</name>
        <name evidence="3" type="ORF">HS99_0031275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="1 2"/>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290965.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5031"/>
    <dbReference type="EnsemblBacteria" id="ARF80092">
        <property type="protein sequence ID" value="ARF80092"/>
        <property type="gene ID" value="B6264_15255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36147">
        <property type="protein sequence ID" value="OEV36147"/>
        <property type="gene ID" value="HS99_0031275"/>
    </dbReference>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="379" mass="40993" checksum="B6A9EB29DE5BFCFC" modified="2017-01-18" version="1">MNFPVVGMIGGGQLARMAHQAGIPLGIRFKLLADTPQDSAAQVVSDVVLGDYRDLDTLRRFAAGCDVITFDHEHVPTEHLRALEADGIAVRPGPEALVNAQDKGVMRAKLDSIGVPCPRHRIVADPADVTAFADEGTGYPVVLKTVRGGYDGKGVWVVDDEQEAQAPFLAGVPVLAEEKVDFVRELAANVVRSPSGQAVAYPVVESVQENGVCAEVTAPAPDLDPALSDEAQQLALRIAGDLGIVGHLAVELFQTRDGRILVNELAMRPHNSGHWTQDGAVTSQFENHLRAVLDLPLGDPRPRARWTVMVNVLGGDYPDMYHAFLHCMARDPGLRIHMYGKDVKPGRKVGHVNVFGDDLDDVRERARHAAAYLRGTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6F1</accession>
    <name>A0A1E7N6F1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0031505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000031">
        <property type="protein sequence ID" value="OEV36033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386915.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000564.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene520"/>
    <dbReference type="EnsemblBacteria" id="ARF78801">
        <property type="protein sequence ID" value="ARF78801"/>
        <property type="gene ID" value="B6264_07620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36033">
        <property type="protein sequence ID" value="OEV36033"/>
        <property type="gene ID" value="HS99_0031505"/>
    </dbReference>
    <dbReference type="OMA" id="WGLGKRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="474" mass="50857" checksum="A4EFB6D5FF712F30" modified="2017-01-18" version="1">MSDLPRKAVTRTARLAALPLGIAGRATLGLGKRIGGRSAEVVTAELQQATADQLFKVLGELKGGAMKFGQVLSVFEAALPEEVAGPYRAALTKLQDAAPPMPAAKVHTALAQRLGSNWRELFLEFDDRPAAAASIGQVHRAVWHDGRQVAVKVQYPGAGDALLADLSQLSRVAWLVGPLIPGLDIKPLINELRERVSEELDYELEAQAQRRHAEEFAGDPDIVVPVVVAQADQVLVTEWMDGTPLAEVIANGTQEERDRAGQLLARFLFAGPSRTGLLHADPHPGNFRLLKDDGPAEGWRLGVLDFGTVDRLPGGLPAPIGASLRMALAGDAAGVLKMLREEGFVKPSIQLDPDAVLDYLLPIIEPAAVDSFHFTRAWMRAQAARIADPRSPAYNLGKQLNLPPAYLLIHRVTLSTIGVLCQLGAKAPFRAEMLEWLPEFSDEPPAKAANPAKAAGPAKHTTAPARTTTKPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6H8</accession>
    <name>A0A1E7N6H8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnE</name>
        <name evidence="7" type="ORF">HS99_0030810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000029">
        <property type="protein sequence ID" value="OEV36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551577.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000574.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000009_gene8038"/>
    <dbReference type="EnsemblBacteria" id="ARF82824">
        <property type="protein sequence ID" value="ARF82824"/>
        <property type="gene ID" value="B6264_13865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36254">
        <property type="protein sequence ID" value="OEV36254"/>
        <property type="gene ID" value="HS99_0030810"/>
    </dbReference>
    <dbReference type="OMA" id="HIKAYWA"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="387" mass="44170" checksum="3396C19C989B2F0B" modified="2017-01-18" version="1">MDAGLKRELEAKVYAGERLTREDGIALYESDDLAWLGGLAHHVRTRKNGDVVHFNVNRHLNMTNVCSASCAYCSFQRKPGEKDAYTMRIEEAVRLAKAMESESLTELHIVNGLHPTLPWRYYPRSLRELKAALPNVSLKAFTATEIHWFEKISGLSADEILDELIDAGLESLTGGGAEIFDWEVRQHIVDHDTHWEDWSRIHRLAHGKGLKTPCTMLYGHIEEPRHRVDHVLRLRELQDETGGFQVFIPLRYQHDFHDSKDGVVRNRLMARTEMATGAEALKTFAVSRLLFDNVPHVKVFWVMHGVTTAQLALSHGADDMDGSVVEYKITHDADNFGTPNKLGREDLLGLIRDAGFRPVERNTRYEIIREYDGPDLTRRETPQAMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6J5</accession>
    <name>A0A1E7N6J5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0030295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000028">
        <property type="protein sequence ID" value="OEV36299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550851.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000197.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2618"/>
    <dbReference type="EnsemblBacteria" id="OEV36299">
        <property type="protein sequence ID" value="OEV36299"/>
        <property type="gene ID" value="HS99_0030295"/>
    </dbReference>
    <dbReference type="OMA" id="CYSLIIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="416" mass="46117" checksum="FBA0DECF9119C4C9" modified="2017-01-18" version="1">MSAPAPAPATVDLGDPATFATHDLDGFWRTLRDTAPVHWNPPVDGRRGFWVLSRHDDILTTYRDDRNFTSERGNVLVTLLGGGDAGAGRMLAVTDGHRHHELRKILQRVLSPRVLDEVARTVRANTRQWIREAVESGGCDFAQQIAARIPMTTISNLLGVPGQDQDHLLGLTRTALSTDDEDVDEVDSEMARNEILMYFMDLVEERREAPGDDVISMLVASAIDGVPLTDEDVVLNCYSLIIGGDETSRLTMIDCVRTLAARPGEWRRLKRHEVAVDTAVDEVLRWASPTMHFGRSVVRETELHGVRLRPGEIVTLWHASGNRDERVFDRPGVFDLGRTPNRHLAFGYGPHFCVGSYLAKVEIAELLIALRDFTTGFEQTGEALPIRSNFLTGFSTLPVRFEPDPAGLDAPAGPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6L1</accession>
    <name>A0A1E7N6L1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284482.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000502.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4889"/>
    <dbReference type="EnsemblBacteria" id="ARF82380">
        <property type="protein sequence ID" value="ARF82380"/>
        <property type="gene ID" value="B6264_29025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36330">
        <property type="protein sequence ID" value="OEV36330"/>
        <property type="gene ID" value="HS99_0029635"/>
    </dbReference>
    <dbReference type="OMA" id="PVPLYQA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="114" mass="12736" checksum="E87B33FEBD01A29F" modified="2017-01-18" version="1">MPVPLYQAKAEFFRTLGHPVRIRVLELLQDGPRPVRELLAEIEVEPSNLSQQLAVLRRTQLVTATREGNTVVYALSTPDVAELLRAARRILTELITDQGALLTELRASGGRSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Q2</accession>
    <name>A0A1E7N6Q2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36370">
        <property type="protein sequence ID" value="OEV36370"/>
        <property type="gene ID" value="HS99_0029880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="72" mass="7427" checksum="036BD37F46DFA8F7" modified="2017-01-18" version="1">MQTLGSLRTSSWPVAASWILTVPLLPGWPLPLPLPPAAACATGASSIRAAAVGTATRERAAVERMCMRVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N720</accession>
    <name>A0A1E7N720_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289763.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene180"/>
    <dbReference type="EnsemblBacteria" id="OEV36469">
        <property type="protein sequence ID" value="OEV36469"/>
        <property type="gene ID" value="HS99_0029525"/>
    </dbReference>
    <dbReference type="OMA" id="RLYAGHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="431" mass="45293" checksum="F6E0011EF36BAA35" modified="2017-01-18" version="1">MKSSEGPVQEASWQWDGEADDAAGAPGDVIGGGGDGPRLSRRGLLVGAGALTLGGAAWAVTGAQGGGPAPRPRPTSVAGPTPLWTYRGPEAMTPERLMVPPDRPVSLSRAGLQVLDPADGGPKRLLSFDPPPPKDWPSDLERPAGNVAVQRDYLYTSASRGHLDAHHLTDPAADWSLPLPDDLQGGLQLTAVDAGVLYGCVLGWPRADSTVPSSRLFAVRLEERSLLWSVAVDRQERPVAHEHLGNQLACVRSLGTGSELVVRDSATGRELWTAPGGGDLSWCTAVGRSFLVPDGSGGVRLLGADGKPGWTRSPARGESWRALPPVPDAVRVLVPRDDGVVTCLETVNGRVLWSCKLPFLLDLRSRPLLHEGTLYVPGPAAGGVGAIHAATGVLGWTFRDSGPGRDVWSLASDGERLYAGHDEVLHALPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N748</accession>
    <name>A0A1E7N748_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288945.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000290.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1443"/>
    <dbReference type="EnsemblBacteria" id="ARF79164">
        <property type="protein sequence ID" value="ARF79164"/>
        <property type="gene ID" value="B6264_09745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36532">
        <property type="protein sequence ID" value="OEV36532"/>
        <property type="gene ID" value="HS99_0028835"/>
    </dbReference>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="30447" checksum="0733F268C34EB076" modified="2017-01-18" version="1">MSDSPSFDPPAGLPRLDRCAVMGVVNVTPDSFSDGGLWFDPAKAIAHGLALRARGADLVDVGGESTRPGTQRVPEEEELRRVLPVVRELAAAGVVVSVDTMRASVAERAVEAGAAIVNDVSGGLADPAMARVVAETGAPFVVMHWRGQSADMDRLAVYQDVVRDVVAELTGRMEALLAAGVKEDQLVLDPGLGFAKTAEHNWALLGRLDALTALGRPVLVAASRKRFLGTLLADPETGELRPARRRDDATAAVSVLSAQAGAWAVRVHDVSGTADAVRVVAAWQRAARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7A1</accession>
    <name>A0A1E7N7A1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385934.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000167.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7905"/>
    <dbReference type="EnsemblBacteria" id="ARF79126">
        <property type="protein sequence ID" value="ARF79126"/>
        <property type="gene ID" value="B6264_09525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36571">
        <property type="protein sequence ID" value="OEV36571"/>
        <property type="gene ID" value="HS99_0029060"/>
    </dbReference>
    <dbReference type="OMA" id="AWRHANT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13282" checksum="DC8B1BB66A127A73" modified="2017-01-18" version="1">MRHLNTPSLTLAKQSLQDAMTRLGWPSSSTLDAELALGELIVNAWRHANTPAPVVQILAVTARTVRVGVSDESPVLPELQSLDLLAESGRGLQLVAALTSRWGVDPQKRGKTIWFECELDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7D7</accession>
    <name>A0A1E7N7D7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0028690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555390.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1473"/>
    <dbReference type="EnsemblBacteria" id="ARF82733">
        <property type="protein sequence ID" value="ARF82733"/>
        <property type="gene ID" value="B6264_09890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36595">
        <property type="protein sequence ID" value="OEV36595"/>
        <property type="gene ID" value="HS99_0028690"/>
    </dbReference>
    <dbReference type="OMA" id="VKAQMTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="475" mass="50373" checksum="E1A209469D105F26" modified="2017-01-18" version="1">MVHWYRSRSLRGRLTFLSAAAVAVAIAMSALACWFIVERQLYGQVRTDLLNAPPQPRIPPTLYCASSPAAAPTAQGSSPTESNGPVLRDVQFVLANTGQVCFAERTPRAITLKPSDTDAYRLKLGQSIIRDGTYTNGDPAVVRVSAAQSHSLGPVLVMVATPTQSVEDSLQGLAILLGAVSLGGILLAAVAGRLVAHSSLKPVDRLTDAVEHIARTEEVGTTIPVRGDDEIARLSTSFNSMSTALANSRERQTRLIADAGHELRTPLTSLRTNVDLLIRSDDTGRPLPPATKTKLLGNMKAQMQELTVLIGDLLQLSRPDTPKAGPNLTVVALHEIAGRAVERAKLRGPGLVFEVSTEPWYTHGDAAGLERAVINLLDNAVKYSPPGGTIEVRLQQGVLTVRDHGPGIPPDELQYVFDRFWRSPSSRQLPGSGLGLSIVAQSVREAGGEVTLGPAEDGGPGALATVRLPGGPGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7Z8</accession>
    <name>A0A1E7N7Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0027360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552953.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4760"/>
    <dbReference type="EnsemblBacteria" id="OEV36825">
        <property type="protein sequence ID" value="OEV36825"/>
        <property type="gene ID" value="HS99_0027360"/>
    </dbReference>
    <dbReference type="OMA" id="VCSTFAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="94"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="364"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV36825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="463" mass="46616" checksum="E4A0CCF47AB03BEA" modified="2017-01-18" version="1">MSGAVPTLAVGQIRRRPAAFAGLAVALFLATGAVTLFGSLVAAQVTAPRAVAREPVEGPGLVVIAGAFGEIAVLVALFVVVNALGFTLRQQHRDLAMLRTVAATPRQIRRLVRAQVAVTVLLAAVPGCAGGLLAARAFLAALQRRGMAAPGLRIPGSPVPMLIALAVALLVGLAATALTARRITRPTPAAALTDSAVGQRWTGVARLLAGAVVLAGGVLLLRLAADRSAAELDKAGQAAMLGSLVLLVAVALLGPVAARLLATVLGAPARLLLPRAGWLADANLRGYAARLSSAVVPVALLVGLAATMLIMTSTAEQAARATGATTSVTKESDVWLRQAELGLLVCFAAVSTVNTLIALTADRRREFALLRLVGATRRQLLRMLSVEAVLTTVVGVLLGAAVAGAATGAFSRAVSGSVLPVVPGAACGWVVAGAAVLTVPGIVGTGLWAIGGRAVEEVGGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N865</accession>
    <name>A0A1E7N865_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282034.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6451"/>
    <dbReference type="EnsemblBacteria" id="ARF78685">
        <property type="protein sequence ID" value="ARF78685"/>
        <property type="gene ID" value="B6264_06935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36869">
        <property type="protein sequence ID" value="OEV36869"/>
        <property type="gene ID" value="HS99_0026750"/>
    </dbReference>
    <dbReference type="OMA" id="SYKARIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="22817" checksum="D1A0F35A5E80EE5E" modified="2017-01-18" version="1">MTIRVLVAEDQAAVRAALVMILRAEPGFEVVGQAADGEEAVRLALELRPDVVLMDVQMPRLDGVSATRQVVAAGAAQVLVLTTFDLDEYVYGALRAGAAGFLLKDLEADTLVEGIRTVARGDGMLAPSVTRRLIGAFARPERPVGPEARAAVAGLTGREREVLACVGAGLSNGEIAARLEMAEATTKTHVSRILAKLRLRNRVQAAILAQDLGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E2</accession>
    <name>A0A1E7N8E2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_037830416.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6820"/>
    <dbReference type="EnsemblBacteria" id="OEV36966">
        <property type="protein sequence ID" value="OEV36966"/>
        <property type="gene ID" value="HS99_0027155"/>
    </dbReference>
    <dbReference type="OMA" id="MHQFKIN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="29800" checksum="4CC8690DD9305A66" modified="2017-01-18" version="1">MTRVPEAATPETAKSVYEREGWLLAPHTLDAELVAGITARIEELSAQERPEAVYEKGTRTLRAIHGCHLFDDLCRRLVRLPALLGLAEELLGEPVYVYQFKVNMKQPREGVAWPWHQDYSFWHHEDGMVADKAVNIAIHLDEVHAKNGPLQIVPRTHHLGLLDKEPSGGGGDWRNHVSADLEYTVPDQVADDLVGEYGLMHATGPKGAIYAFHPTLVHSSTDNLSDDRRALLLVTYNAVSNAPERLSRPEFLVSRDTTPLTPVAANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8L6</accession>
    <name>A0A1E7N8L6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0027835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553052.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000514.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4858"/>
    <dbReference type="EnsemblBacteria" id="ARF82404">
        <property type="protein sequence ID" value="ARF82404"/>
        <property type="gene ID" value="B6264_29175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36813">
        <property type="protein sequence ID" value="OEV36813"/>
        <property type="gene ID" value="HS99_0027835"/>
    </dbReference>
    <dbReference type="OMA" id="FAYRRKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV36813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="738" mass="75762" checksum="D82697D819465BFA" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8S1</accession>
    <name>A0A1E7N8S1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386560.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000404.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7413"/>
    <dbReference type="EnsemblBacteria" id="OEV37081">
        <property type="protein sequence ID" value="OEV37081"/>
        <property type="gene ID" value="HS99_0004470"/>
    </dbReference>
    <dbReference type="OMA" id="PFWANTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198879" evidence="1">
        <location>
            <begin position="33"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="425" mass="45750" checksum="1EE1B98B14032AA4" modified="2017-01-18" version="1">MPTVPSLRSRWASAAAGLAVVVSTLAGCGSGGQNGPVTLNWYNFPDDSGALQQAADRCGQQSGGRYTIRYDKLPRGADGQRQQLVRRMAAHDTDVDILGLDVTWPAEFAEAGWIREWTGKLRDRGTADTLDAAVRTATWRGRLYATPYNSNTQLLWYRDDLVRTPPRTWAEMLATAEDLARAGKPHYVEIQGAQYEGLTVWFNTLVASAGGSVLTPDAQAPSLGPPAVAAATVMHDLATSAAADPSLPNQMEDQNRLAMESGTAAFELNYPFVYPSMKANQPALFPHFHWAPYPAVTPDRPAGVTIGGIDLAVGAYSRHPDLAFEATLCLRSRDNQLTNALKGGLPPSLRSLYRTEELTRSYPFAADVLAALDSASVRPQTPAYQNVSIAISHTLSPPAGIRPEKDVADLRGQIQDALGSKGLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N988</accession>
    <name>A0A1E7N988_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555194.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1315"/>
    <dbReference type="EnsemblBacteria" id="OEV37255">
        <property type="protein sequence ID" value="OEV37255"/>
        <property type="gene ID" value="HS99_0005500"/>
    </dbReference>
    <dbReference type="OMA" id="VWGANHD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="177"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="408" mass="45252" checksum="1DC94B509719B0B5" modified="2017-01-18" version="1">MKQLLFPNNIQFWYETLRSMSHIAYGGADFGEVVSTGERIVEGDYNSWYTEWLATADRVSGEAEKALKAGHRVSARDGFLRASNYYRSAEFFLHGHPCDPRHDKAYNRSVACFRAAAALFTTPRIEPVEIPYEGTTLPGYLYRVDGSGAPRPTLIMHNGFDGTAEELHFFGAMAGVERGYNVLVFDGPGMPGPRHHQGLVFRPDWENVITPVVDFAETLPEVDNRRIALLGISMGGILAPRAAAFERRLAALIAVDGLYDLGQTSVRNIPGTREEAERLLRAEHAPELDSALEQIMAKDPIARWAINHGMYVMGVDTPRAFNASYLDYTLAGGTAEKIQCPTLVCDAEEDMFFKGQPEQLYDHLTCPKTLMVFTTEEGAGAHCHPGAMRLSIARIYNWLDDILANTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9A8</accession>
    <name>A0A1E7N9A8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555141.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1284"/>
    <dbReference type="EnsemblBacteria" id="OEV37280">
        <property type="protein sequence ID" value="OEV37280"/>
        <property type="gene ID" value="HS99_0005655"/>
    </dbReference>
    <dbReference type="OMA" id="GRAVGCI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="20300" checksum="D46199E3EB8E5C92" modified="2017-01-18" version="1">MDQIVNVVGVGGSSRPGSTAEKALRVVLDAAQRRGAAVQLISGPALAMPLYDPRHGATAPQARRLLAAVAGADALVLASPAYHGGISGLVKNALDHVEELSEDIRPYFSERAVGCVAVANGWQGAVSTLAALRDVTHALRGWPTPLGAAINTSAARFSPAGACMDAHVQGQLEEMAAQVVEFATMRALATSRAQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9F6</accession>
    <name>A0A1E7N9F6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37321">
        <property type="protein sequence ID" value="OEV37321"/>
        <property type="gene ID" value="HS99_0005905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="261" mass="28062" checksum="311C8B850037F19D" modified="2017-01-18" version="1">MARWFGFTGARALRSFFELRGSGTEGDIMRPEFVTVMGTGYVARSVADRLADAGLTPSNPPTGGAHVLVTGFAVAEPSPHIFEETRRVLAAMTPGSWWIDMTHPPLRTDDLWVPPEDLARVTRVRVPVTDVRGVLVASPPVDLDLRSRQVCGAILRVADLVLPTQTPEFPAARHNDLVWLGRRGPWGKGTAGGTGARGAVRRVGCCCGAWLPCWGWRSWCSASSATTMPTTRAGPTSTHLSAMPGRTGRHRWTACGPRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9G1</accession>
    <name>A0A1E7N9G1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">6-aminohexanoate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555742.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000155.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000045_gene6672"/>
    <dbReference type="EnsemblBacteria" id="ARF81617">
        <property type="protein sequence ID" value="ARF81617"/>
        <property type="gene ID" value="B6264_24340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37113">
        <property type="protein sequence ID" value="OEV37113"/>
        <property type="gene ID" value="HS99_0004650"/>
    </dbReference>
    <dbReference type="OMA" id="WDIILTP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="483" mass="50770" checksum="B1FB37452A2E8A18" modified="2017-01-18" version="1">MDVKDYVGFDAVGLAELIARGQVTPAEVEAAAREAVRAVDPQLNAVVEIWPADDGPRPGSAPLAGVPFLIKDLGITMAGRRTELGSRLAAGNVAAADSTLMSRFRRAGLVTFGRTATPEMAYSTTTESVLYGPTRNPWDLTRSAGGSSGGAGAAVASGIVPLAHATDAAGSIRIPAAYNGLFGLKPTRGRIPVGPDVDEIFNGLAVQGCVSRTVRDSALLLDLVSGPAAGDPYVAPEPPRPYAQEVSRDPGSLRIGVLAQPWGGHRTTAPVAEALSRTVRLLESLGHRVEQAQAELGVDWEEFVLANGRQWTANLTAWIDELAAASGRPVDFSTLEPPILASYHYGRRVTGTELVTALAVRNRVSRSLARSFDAYDVLLTPTMPDLPVPLGTHGRGAETLDGLGWLRRLLDLSPFTAAFNVAGTPAMSVPVTADPGTGLPVGMQFAAGYGREGRLFRLAGQLEQAAPWSDRIPTVWAGSHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9L2</accession>
    <name>A0A1E7N9L2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37334">
        <property type="protein sequence ID" value="OEV37334"/>
        <property type="gene ID" value="HS99_0005995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="64" mass="6999" checksum="FFB30400BBDC6FAE" modified="2017-01-18" version="1">MSGVLELRRIEDDPGLLGQLPHRAEQGVLVGVQSAGRVVPDARQDVVREPVRHQHHGFVVGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9R6</accession>
    <name>A0A1E7N9R6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene154"/>
    <dbReference type="EnsemblBacteria" id="OEV37408">
        <property type="protein sequence ID" value="OEV37408"/>
        <property type="gene ID" value="HS99_0003845"/>
    </dbReference>
    <dbReference type="OMA" id="WPIVCRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12395" checksum="74C3A02A0856C7AC" modified="2017-01-18" version="1">MEGDFGRLLADAQLAVTELVVNAHRHGGGLTGFGARLDLERGCLVVDVEDGDERHPVGEPLDRRDPTAAGGRGWALVQILASTCHIDALPQGGKRIRVTFSLGRATAGRRSPSAGAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9X7</accession>
    <name>A0A1E7N9X7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287141.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000195.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7965"/>
    <dbReference type="EnsemblBacteria" id="ARF79079">
        <property type="protein sequence ID" value="ARF79079"/>
        <property type="gene ID" value="B6264_09245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37495">
        <property type="protein sequence ID" value="OEV37495"/>
        <property type="gene ID" value="HS99_0026110"/>
    </dbReference>
    <dbReference type="OMA" id="TGPGPWI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="68" mass="7880" checksum="641740EE0841E3D6" modified="2017-01-18" version="1">MERTEQLDWQRSSFSTDQANWLEIASEGEFVYIRESDNPELVVTTTRTKLNAWILGAKDGEFDHFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA46</accession>
    <name>A0A1E7NA46_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1126"/>
    <dbReference type="EnsemblBacteria" id="ARF79006">
        <property type="protein sequence ID" value="ARF79006"/>
        <property type="gene ID" value="B6264_08825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37565">
        <property type="protein sequence ID" value="OEV37565"/>
        <property type="gene ID" value="HS99_0026530"/>
    </dbReference>
    <dbReference type="OMA" id="FRDPLDQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="11130" checksum="E03D2E937A17507A" modified="2017-01-18" version="1">MDRVSERRQEQGPGEQGQGEQGHGGQGREEQDRRQPKAQGTPAEAKAQAEGTAKARLVFRDPLDQQSRDDTDAGWGDRPGAGESGGRGLDWYLSQRPPHHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA63</accession>
    <name>A0A1E7NA63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase subunit sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0006285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556381.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5401"/>
    <dbReference type="EnsemblBacteria" id="ARF82498">
        <property type="protein sequence ID" value="ARF82498"/>
        <property type="gene ID" value="B6264_29760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37383">
        <property type="protein sequence ID" value="OEV37383"/>
        <property type="gene ID" value="HS99_0006285"/>
    </dbReference>
    <dbReference type="OMA" id="SQQHVHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="312" mass="34152" checksum="48690744C2860171" modified="2017-01-18" version="1">MDSVAIDRFEASRGLLAPLAYRLLGSAADAEDAVQEAFLRWQAADRDQIEVPEAWLTKVVTNLCLDRLRSAQARHERAAGDWLPEPLLEGDPMLGPADTFEQRESVSLAVLTLMERLSPVERAAFVLREAFSYPHAEIARILDISESASQQHVHRARRRVATERRGGDVVDPASARRVVEEFLAAATSGRTERLVALLTDDAVAVSDGAGLARRLLWYNTRERIASYVRAGFKPTPAKRRMAGGSPALHIALLNGSPAVMAVIEGRVVGVVAFEVSDGKVASLRGIAAADRLTRLNEAWRQHEPDAPVINAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD3</accession>
    <name>A0A1E7NAD3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280716.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1707"/>
    <dbReference type="EnsemblBacteria" id="ARF79906">
        <property type="protein sequence ID" value="ARF79906"/>
        <property type="gene ID" value="B6264_14220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37649">
        <property type="protein sequence ID" value="OEV37649"/>
        <property type="gene ID" value="HS99_0025435"/>
    </dbReference>
    <dbReference type="OMA" id="AEFNIRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="26370" checksum="9DC1BB5A340C26C8" modified="2017-01-18" version="1">MNAKRPLIAVLTGAGISTDSGIPDYRGPQGLWQRDPSAQELVTIGPYLADPEVRKRAWLMRRDAGAMAAEPNAGHRALVDLERSGLPLRVLTQNVDGLHQRAGLPARKVFELHGTAREVQCARCRVVGPMDEALARVAAGEPDPACRECGGILRPRTVMFGEALDPVVLQQADAVAKACDLFVAVGTSLQVFPVAGLPLIAVETGAKLIIVNAEPTPYDEAAAEVIREPISTALPELVRRLVRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAU3</accession>
    <name>A0A1E7NAU3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0024830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557050.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000142.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000059_gene3740"/>
    <dbReference type="EnsemblBacteria" id="ARF78048">
        <property type="protein sequence ID" value="ARF78048"/>
        <property type="gene ID" value="B6264_03160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37816">
        <property type="protein sequence ID" value="OEV37816"/>
        <property type="gene ID" value="HS99_0024830"/>
    </dbReference>
    <dbReference type="OMA" id="GSIVIHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="393" mass="39793" checksum="063734CB1D188D8A" modified="2017-01-18" version="1">MRIPLLALAAGAFGIGTTEFAMMGLLPDIAADFHTSIPTAGYLISAYALGVVVGAPLLAGLLLRLSYRSALLVMMALFAVGHALSAFSSDFALLLATRFLTALQHGAFFGVGAIVAATLVPAQQRARAVSMMFSGLTVANIVGVPLSPLLADHLGWRSTFWLLSVIGLLCLLGIAVTIPAQGRPKAVSFRSELRAFRRRQLWLALATTALGYGGVFAAYSYVSPMITNLTGSGTGAVAVVLCLFGIGMTAGNYLGGRLADRNRRTALGGALAVLTVALFALSVTAHWLVPAAATVLLIGAASSAAVPSLQTWVMDEGGEAATLASASIHSAFNLGNALGAALGGAAITADLGYTAPGWVGALMAIGALGCALAAGPSLTAGRVAVAEPAQQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB32</accession>
    <name>A0A1E7NB32_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnpA</name>
        <name evidence="7" type="ORF">HS99_0023800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278250.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF79452">
        <property type="protein sequence ID" value="ARF79452"/>
        <property type="gene ID" value="B6264_11470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37902">
        <property type="protein sequence ID" value="OEV37902"/>
        <property type="gene ID" value="HS99_0023800"/>
    </dbReference>
    <dbReference type="OMA" id="THHVVIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV37902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="142" mass="15495" checksum="1E7043FACFBFB755" modified="2017-01-18" version="1">MLPSENRLRRRQDFATAVKRGRRAGRPLLVVHLSRDGDPQGQTDRTSDSRPHVAEGTPSARAGFVVSKAVGPAVVRNLVKRRLRHLLRDRLSRLPAGSLIVVRALPQAATASYQDLERDLDAALKRLLRAEPAATAPTGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB53</accession>
    <name>A0A1E7NB53_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol 1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278269.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2101"/>
    <dbReference type="EnsemblBacteria" id="ARF79468">
        <property type="protein sequence ID" value="ARF79468"/>
        <property type="gene ID" value="B6264_11565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37917">
        <property type="protein sequence ID" value="OEV37917"/>
        <property type="gene ID" value="HS99_0023895"/>
    </dbReference>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="39554" checksum="C6EB6396178590D8" modified="2017-01-18" version="1">MGSVRVAIVGVGNCAASLVQGVEYYKDADPAGKVPGLMHVQFGDYHVRDVEFVAAFDVDAKKVGFDLADAIGNSENNTIKICDVPPTGVTVQRGHTLDGLGKYYRETIEESDEAPVDVVQVLKDKQVDVLVCYLPVGSEDAAKFYAQCAIDAKVAFVNALPVFIAGTKEWADKFTEAGVPIVGDDIKSQVGATITHRVMAKLFEDRGVILERTMQLNVGGNMDFKNMLERERLESKKISKTQAVTSQIRDRELGAKNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPILSASSYFMKSPPVQYFDDEAKENVEKFIRGEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC33</accession>
    <name>A0A1E7NC33_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290717.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000593.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000089_gene1742"/>
    <dbReference type="EnsemblBacteria" id="ARF80231">
        <property type="protein sequence ID" value="ARF80231"/>
        <property type="gene ID" value="B6264_16105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38252">
        <property type="protein sequence ID" value="OEV38252"/>
        <property type="gene ID" value="HS99_0022175"/>
    </dbReference>
    <dbReference type="OMA" id="YKWMPPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="329" mass="32896" checksum="0070F1E01DB58C28" modified="2017-01-18" version="1">MRALVMTAPGGAENSEIRQIEAPHPGPGQVAIDVAWAGLNFVDVMARRGDAGYTAEWPYLPGKEVAGTVRELGEGVTGLAVGDRVVAAPVGGGLAEVVVADAVLTLPVPDGLELRTAAAAPLGLATAVLLLTDAGRLTAGDNVLVHSAGGGVGSAVAQLVPLLGGGGTLIGTVGRPEKAAAAVDLGYHHAFARDEKLADAVRTATGGRGVDLVLDPLGTAALELDLTVAAPGARIVLFGNAGGGEVGALPPLGRLMGGNLSVTGFSHRAFAATAPERLARAIRTTLDLQANSGLGIPLTELPGLEAVPAAHDAMQEGRATGKYVVRMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCG4</accession>
    <name>A0A1E7NCG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553571.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000516.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000022_gene3946"/>
    <dbReference type="EnsemblBacteria" id="ARF82237">
        <property type="protein sequence ID" value="ARF82237"/>
        <property type="gene ID" value="B6264_28170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38375">
        <property type="protein sequence ID" value="OEV38375"/>
        <property type="gene ID" value="HS99_0020890"/>
    </dbReference>
    <dbReference type="OMA" id="SNCSWHL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="21948" checksum="6C0D54139E09AE21" modified="2017-01-18" version="1">MEHGNRLGDIEITDPKAMRALAHPVRLAILERLQRHGPATATQLSPDVGATPSVTSWHLRHLAGFGLVQDAEAAADRRERRWEAVARGFRFGMPADEAGQSAARMLSREMFARSADLPHRWVTETEPELDPMWRKPAGLANTRVVVSPDELAAIEDAIQGVLAPYVTRDPAQRPSGSRGVRLLRYVLPEAHEERAGESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND08</accession>
    <name>A0A1E7ND08_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene655"/>
    <dbReference type="EnsemblBacteria" id="ARF77605">
        <property type="protein sequence ID" value="ARF77605"/>
        <property type="gene ID" value="B6264_00525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38580">
        <property type="protein sequence ID" value="OEV38580"/>
        <property type="gene ID" value="HS99_0020110"/>
    </dbReference>
    <dbReference type="OMA" id="VYSSMDR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="466" mass="51566" checksum="F88059355D79FCB6" modified="2017-01-18" version="1">MPAEPDRPAFDLAALLAERGGERYELHSRYLNPQLPRMLRTIGFDKYYERAEGQYFYDAEGNEYLDMLAGFGIFALGRHHPAVRAAVRQVMDLELPDLVRFDCSPLPGLLAERLLSHAPGLERVFFGNSGTEAVETALKFARYATGRKRVLYADHAFHGLTTGSLSVNGESGFRKGFDPLLPDTAIPLGDIGALTKELKRGDVAALIVEPIQGKGVQAPPPGWLRAAQALLHEHKALLICDEVQTGIGRTGEFFAYQHEEGVLPDLVCAAKALSGGYVPIGATLGKSWIFEKVYSSMDRVLVHSASFGSNAQAMAAGLATLEVMREEKVVENARQVGDRLRERLTELVDRYELVAEVRGRGLMTGIEFGRPRSLKLRTGWTALQAARKGLFAQMVVVPLLQRHRILTQVSGDHLEVIKLIPPLIITDRDVDRFLDAFTEIMDEAHRGNGLMWDFGRTLVRQAVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND11</accession>
    <name>A0A1E7ND11_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0019865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281354.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000310.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene704"/>
    <dbReference type="EnsemblBacteria" id="ARF77567">
        <property type="protein sequence ID" value="ARF77567"/>
        <property type="gene ID" value="B6264_00280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38544">
        <property type="protein sequence ID" value="OEV38544"/>
        <property type="gene ID" value="HS99_0019865"/>
    </dbReference>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="358" mass="39167" checksum="6A09F820D2448B5C" modified="2017-01-18" version="1">MTDLTRTDAVRRHDPAVRGFASDNYAGVHPEVLAAITLANGGHQISYGEDDYTAHLQDVFRRHFGDKAEAYPVFNGTGANVVALQALLPRWGAVVCADTAHIHVDEGGAPEKMGGIKLHTVSTPDGKLTPELLDRQAFGFGDEHRAQPLAVSITQSTELGTLYTIDEIRAVVDHAHQLGMLVHMDGSRLANAAASLGQPMRAFTTDLGVDVLSFGGTKNGLLLGEVVVVLNPERVRNIKYLRKTSMQLASKMRFVSVQFEALLAGDLYLRNAGHANAMASRLEAAVRKIDGVEVVRPVQANAVFAILPREVSERLQKRYRFYFWNEHTGEVRWMCSYDTTEADIDAFAAAIAEEMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND64</accession>
    <name>A0A1E7ND64_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0020390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281151.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000383.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene600"/>
    <dbReference type="EnsemblBacteria" id="ARF77652">
        <property type="protein sequence ID" value="ARF77652"/>
        <property type="gene ID" value="B6264_00805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38621">
        <property type="protein sequence ID" value="OEV38621"/>
        <property type="gene ID" value="HS99_0020390"/>
    </dbReference>
    <dbReference type="OMA" id="DYPHLGQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV38621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="216" mass="23299" checksum="02627844D07AC101" modified="2017-01-18" version="1">MARPRTPLLSRDRIVAAALRLIDGEGLEVLSTRRLAAELSVSGPSLYNHFATKDELLDAVVDSVIGEVDLSMFGRPDTPWPEALRAWARSYRAALAAHPNIVPVLAQGPGRRPNALRLADAVFGHLVDSGWPRGQATRIGALMRYFVTGSALASFAAGFPADAEVYDAADYPHLGEAHRLAGHRGTVDEGAFETGLEALLEGLVLRFERLAARPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND75</accession>
    <name>A0A1E7ND75_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0020460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551429.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000424.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene586"/>
    <dbReference type="EnsemblBacteria" id="ARF77665">
        <property type="protein sequence ID" value="ARF77665"/>
        <property type="gene ID" value="B6264_00875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38631">
        <property type="protein sequence ID" value="OEV38631"/>
        <property type="gene ID" value="HS99_0020460"/>
    </dbReference>
    <dbReference type="OMA" id="HRTTIRW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="T2SSF" evidence="6">
        <location>
            <begin position="124"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV38631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="317" mass="34355" checksum="15BBB014CAA09227" modified="2017-01-18" version="1">MLLLALCGLAVAGGLVALVAWARGSEPDDGDGPARRENPLAGRAHVFWYGAPGSASLRMVRLRRIQLPLALVGGPLAWLFTGIPLTALLVPLAVFGLPWLFDTTRPDTHRIERLEALSEWTQRIADVLLLGVGLNQAIVTSRRTAPAALEDEIGELAARLQARWRPEEALHAFADSLADATADKVLAALVLRAGDSGPGLARTLSDMADSVREEVRQRRAIEADRAKHRTTIRWLVGIIVLVVTVGSFNTEYTRPYGTFLGQVVLAVVAALFVAIIAWMRALASHPPVPRLLTPDRRSKGGRRGPVQEPVEQLGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDG4</accession>
    <name>A0A1E7NDG4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552199.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000313.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1808"/>
    <dbReference type="EnsemblBacteria" id="ARF82544">
        <property type="protein sequence ID" value="ARF82544"/>
        <property type="gene ID" value="B6264_01190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38729">
        <property type="protein sequence ID" value="OEV38729"/>
        <property type="gene ID" value="HS99_0020775"/>
    </dbReference>
    <dbReference type="OMA" id="MYHHFKG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="20225" checksum="7E92306C3EBD2094" modified="2017-01-18" version="1">MTTQDRLIESTQALLWERGYVGTSPKAIQQLSGVGQGSMYHHFNGKPDLAAAALRRSAEQMRGTAEADLAAPGTAYDRIAAYLNRDREVLRGCRIGRMAQDPDVVADPQLRAPVEETFDWLRGRIAELVAEGQAHGEFAPGLDPADTAAAVVAVVQGGYVLARAADSAAPFEQAVRGALGLLATRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX9</accession>
    <name>A0A1E7NDX9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0019520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366898.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38855">
        <property type="protein sequence ID" value="OEV38855"/>
        <property type="gene ID" value="HS99_0019520"/>
    </dbReference>
    <dbReference type="OMA" id="FRAPAHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="294" mass="31157" checksum="FC09A6346756C8D1" modified="2017-01-18" version="1">MHVHFIAPARYVRASHEIVRHPRLRATAKTLLLWALSLPPGSRDTILTIGKRMPEGRTAVARARAQLIEEGYLHVRRSQHPTKGTWTTRVLVSSVPLTEPDEIETAWRGSVRNPALGEGEGREAGTSPKGEKNEGKTSSRAATVTVAGAAEGEAAGLLGRLTARDRRLRLGAAEVLDLAPLVADWLARDPDMGRLREALLGGLPSHVLAPAGFVRARLERRMPEAVAGPGAAAGGMRECASCADPVEGGGVVCRRCTGVAPLEGGPDTAAVERNRRGAERARSLLRGAMVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEY3</accession>
    <name>A0A1E7NEY3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HS99_0000450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285244.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000770.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3553"/>
    <dbReference type="EnsemblBacteria" id="OEV39232">
        <property type="protein sequence ID" value="OEV39232"/>
        <property type="gene ID" value="HS99_0000450"/>
    </dbReference>
    <dbReference type="OMA" id="AASWFPC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="12">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="11">
        <location>
            <begin position="246"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OEV39232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="447" mass="48840" checksum="CC537473DD029BDD" modified="2017-01-18" version="1">MKPHHAPPAAGGPDPYFPNSGDHRYRVHRYEIALDYRPGPNRLAASARLSAVANAALAEFALDLAEFRIGRMLVDGRAARYTHRGGKLRVRPAKALAAGAAFTVEVHYTGNPRPVRSPWGGLGWEELTEGALVASQPVGAPSWYPCNDRPADKATYQVAVTTPSPFTVLSGGRLLTRTTRASSTTWVYEQSAPTSSYLVTVSIGHYRPVPLTACPTTPRAGSVPQTGYVPQRLADAFARDFARQPEMMAYFTEAFGPYPFGEYAVVVADEELDVPVEAQGVATFGTNHLGGGWERERLIAHELAHQWFGNSVTIADWRHIWLNEGFAKYAEWLWSEHTGGPGAAVHAAAAHRLLAGLPQDLRLGDPGRKLMFDDRLYQRGGLTVHALRRALGEDAFFAMLRDWAGVHQHGVVATSDLLAHASRYTATPLGPLFEAWLERPELPPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFF2</accession>
    <name>A0A1E7NFF2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558142.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000447.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000094_gene561"/>
    <dbReference type="EnsemblBacteria" id="OEV39404">
        <property type="protein sequence ID" value="OEV39404"/>
        <property type="gene ID" value="HS99_0001495"/>
    </dbReference>
    <dbReference type="OMA" id="LPHRWID"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="604" mass="64762" checksum="16C59C034A9A411A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFU1</accession>
    <name>A0A1E7NFU1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555622.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000044_gene6753"/>
    <dbReference type="EnsemblBacteria" id="OEV39544">
        <property type="protein sequence ID" value="OEV39544"/>
        <property type="gene ID" value="HS99_0002340"/>
    </dbReference>
    <dbReference type="OMA" id="EARWWRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="306" mass="32155" checksum="FEA3716EE06E388E" modified="2017-01-18" version="1">MSAGWVGGATRARALLSRCLGLQGARELASAPTLGDALRQLAATPYRRDLLPDADLAQAQRAVSETLLWHLRVLAGWLPRAGANALRVLAGGFEIANIEGRLRSFTGVEPPPPYRLGALATAWRRLAQAGSPAELRAALAASAWLDPGGEDPASVATALRVAAAARTAEAVPPARRWAAGRAALLAARDRYVTGRPLPAAAARRAAPLLGPRAVGAASFEEFRRHLVPDARWAVDGVEDAADLWRAEARWWTVLDRDGGALLRGTHFGLAPVVGAVAVLSADVWRVRAALVLAERGGSPEAFDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFY3</accession>
    <name>A0A1E7NFY3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0002805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550328.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000102.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2755"/>
    <dbReference type="EnsemblBacteria" id="OEV39619">
        <property type="protein sequence ID" value="OEV39619"/>
        <property type="gene ID" value="HS99_0002805"/>
    </dbReference>
    <dbReference type="OMA" id="TGRWRTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="273" mass="30118" checksum="8D4C3492FD27C5BD" modified="2017-01-18" version="1">MTDDRSALTDRSKPSIARVYDYLLGGEENYAVDREIGDFFLRDLPGSVAIAHANRRALVRAVGAMVREGVQQFVDMGSGLPTADNVHQVALRHAPGARVAYVDHDPTVLAHGRALLGSAGRSTLVQADLREPESIRDHPDVRRLIDFNEPVAVVFSAVLHHLDDSEHPAALVRWWVDRVPPGSLVYISHFRSGGNEEARIAEQKLQDSFGRGRWRTDEEILGLFDGLELLEPGLVPCSLWRPEPEADGTAAPSDEADLPVWERLISCALARMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFZ3</accession>
    <name>A0A1E7NFZ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550337.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2767"/>
    <dbReference type="EnsemblBacteria" id="OEV39631">
        <property type="protein sequence ID" value="OEV39631"/>
        <property type="gene ID" value="HS99_0002865"/>
    </dbReference>
    <dbReference type="OMA" id="YRWVLKP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="26774" checksum="791CC9584BE5182D" modified="2017-01-18" version="1">MNEHISRQLREAAGAHQPDRARMLARVQRGAAGPAPRHRTRSGLRSWPRAAIAGLAAAGILATGGLAMAGITQAPPPSEATTAPAPPSPVVTPTPTRPAPPAATAPATAPAPAAVTPPSPHPTPSASAGSRTQNGPLWSAGSIGSHSNAYWSESDLVLRTSQPLTSLTVELRVAQTGGVRDTGNWRTLPADDFTVTVQEAGGALVYRWVLKPGRTVPPGEHQFAGQYNHATGVRAATGDGYRAEAQSTGGPATVWGGFTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVC0</accession>
    <name>A0A1E7MVC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fic family toxin-antitoxin system, toxin component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289584.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000741.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6974"/>
    <dbReference type="EnsemblBacteria" id="OEV32380">
        <property type="protein sequence ID" value="OEV32380"/>
        <property type="gene ID" value="HS99_0016920"/>
    </dbReference>
    <dbReference type="OMA" id="TTIRTWY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13407" checksum="BB495B79F5EF7238" modified="2017-01-18" version="1">MILRIDRTWLLDLAHQFLPGDPDVTDYGTLAAAVARHADEVMDVPVYGAVHQRAAALMHQLIRVPALESANEHFAAVVAAAYLSASGVIVTAEPKHAVDLAARIRAGHADVRETSTTIRTWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVI7</accession>
    <name>A0A1E7MVI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557435.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000126.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000067_gene1192"/>
    <dbReference type="EnsemblBacteria" id="OEV32447">
        <property type="protein sequence ID" value="OEV32447"/>
        <property type="gene ID" value="HS99_0017345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="13832" checksum="AA5ED15918AA604D" modified="2017-01-18" version="1">MTAVTATGEAFPPRPVRGVRARYVLQGGCGPFADAVVDFEPWEEGVHLEVAAGATVYGGAASQEGLARYHAALAEGVRAELAEQLPDAMVALALVVRRTGVHDVDTSEYAYRRAGQVAVREVLALLGAGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVT0</accession>
    <name>A0A1E7MVT0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein HS99_0040175</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0040175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000093">
        <property type="protein sequence ID" value="OEV32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1914"/>
    <dbReference type="EnsemblBacteria" id="OEV32547">
        <property type="protein sequence ID" value="OEV32547"/>
        <property type="gene ID" value="HS99_0040175"/>
    </dbReference>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="103" mass="10557" checksum="7C21DB8C0B787A8A" modified="2017-01-18" version="1">MQQLLKQAQKMQQELAKAQQELAEAKVNGTAGGGLVEATVTGSGELVALTIAPAAVDPEDTETLADLILAAVRDATQAAQKMQAERMGPLTQGMGGGIPGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV0</accession>
    <name>A0A1E7MVV0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0040160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000092">
        <property type="protein sequence ID" value="OEV32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000077_gene7191"/>
    <dbReference type="EnsemblBacteria" id="OEV32555">
        <property type="protein sequence ID" value="OEV32555"/>
        <property type="gene ID" value="HS99_0040160"/>
    </dbReference>
    <dbReference type="OMA" id="SHWQAAV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="233" mass="24482" checksum="0608805FE6303173" modified="2017-01-18" version="1">MRVDARRNLESVLRAAREVFGEFGYGAPMEEVARRAGVGVGTVYRRFPSKEVLVQRIAAEEVAWLTAQARESLYGGDGAWEALAGYLARAVSTGAGRLLPPEAFRYAEELGRVPEQRAPEPPAAVRFDLRGEEARSGAAAEPSPADADPRLLLQLLAALVARAGAAGELRPGVTVSDVVLVLTASVPVHAARPSVSAPTAAGFTAVGPQTDGQPAAAPSDRLLQILLDGLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVV8</accession>
    <name>A0A1E7MVV8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0040125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000090">
        <property type="protein sequence ID" value="OEV32561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000071_gene7119"/>
    <dbReference type="EnsemblBacteria" id="OEV32561">
        <property type="protein sequence ID" value="OEV32561"/>
        <property type="gene ID" value="HS99_0040125"/>
    </dbReference>
    <dbReference type="OMA" id="DPWTERQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198473" description="DUF11 domain-containing protein" evidence="2">
        <location>
            <begin position="36"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="700"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1071" mass="110667" checksum="2422E8F172EABDC4" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVY6</accession>
    <name>A0A1E7MVY6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold-shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0015055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287940.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000601.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3811"/>
    <dbReference type="EnsemblBacteria" id="ARF78367">
        <property type="protein sequence ID" value="ARF78367"/>
        <property type="gene ID" value="B6264_05025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32595">
        <property type="protein sequence ID" value="OEV32595"/>
        <property type="gene ID" value="HS99_0015055"/>
    </dbReference>
    <dbReference type="OMA" id="HYSTIKM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="70" mass="7845" checksum="B46921EB69DE9DFE" modified="2017-01-18" version="1">MAERQHGTVKWFNDEKGYGFITPESGPDLFVHFRAIEGGGFKSLVEGQKVTFEAVQGQKGMQADKVRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW51</accession>
    <name>A0A1E7MW51_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0015460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000036_gene3155"/>
    <dbReference type="EnsemblBacteria" id="OEV32667">
        <property type="protein sequence ID" value="OEV32667"/>
        <property type="gene ID" value="HS99_0015460"/>
    </dbReference>
    <dbReference type="OMA" id="VLYMFGT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="197" mass="21411" checksum="3E6EC9114D6D51E6" modified="2017-01-18" version="1">MGYLPDRDQTLMKLLVAGPFGVGKTTLIRTLSEIATLHTEEAMTETGRPVDDLAGLPEKSTTTVAVDFGRLTLPGNTVLYMFGTPGQRRFFPLWQDIARGALGALVLADTRRLADSFEIMDMIEEQGLPYAVAVNRFPGSPDHPPEVLRAHLDLHAATPLLLCDARERGSSLDALIALAEHVLDTLPAAATDPRERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MW92</accession>
    <name>A0A1E7MW92_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SUF system NifU family Fe-S cluster assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290235.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000651.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7866"/>
    <dbReference type="EnsemblBacteria" id="ARF78254">
        <property type="protein sequence ID" value="ARF78254"/>
        <property type="gene ID" value="B6264_04385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32707">
        <property type="protein sequence ID" value="OEV32707"/>
        <property type="gene ID" value="HS99_0015700"/>
    </dbReference>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="150" mass="16105" checksum="34B5FFCA2569A589" modified="2017-01-18" version="1">MKLDSMYQDIILDHYRNPHGKGLRDGDAEVHHVNPTCGDEITLRVKLDGANVADVSYESQGCSISQASASVLNDLVVGKTVGEAQAVQEAFLELMQSKGQGEGDEEVLEDAVAFAGVSKYPARVKCALLSWMAWKDATAQALAQNPAVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWC8</accession>
    <name>A0A1E7MWC8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366533.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000489.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7843"/>
    <dbReference type="EnsemblBacteria" id="ARF78236">
        <property type="protein sequence ID" value="ARF78236"/>
        <property type="gene ID" value="B6264_04270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32724">
        <property type="protein sequence ID" value="OEV32724"/>
        <property type="gene ID" value="HS99_0015815"/>
    </dbReference>
    <dbReference type="OMA" id="GPHANLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="171" mass="18905" checksum="9D837F5845F3DB1A" modified="2017-01-18" version="1">MPYRLDITQGDWPGDLLHKGVDGLLAEAMVLTLATAGHEHGPHANLAFFAHDDDLVLYFVSERSTRHSHHLAEEARAAATVFLPPPAFGEQLRGLQLTGSASEAWGRQAEAALAAYQGRYPSFAQDEETRRQYLTGSGAAALYRFQVEELTAVDEPNFGRRNYLRARVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWL7</accession>
    <name>A0A1E7MWL7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0015275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000296.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3855"/>
    <dbReference type="EnsemblBacteria" id="ARF78326">
        <property type="protein sequence ID" value="ARF78326"/>
        <property type="gene ID" value="B6264_04805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32633">
        <property type="protein sequence ID" value="OEV32633"/>
        <property type="gene ID" value="HS99_0015275"/>
    </dbReference>
    <dbReference type="OMA" id="NEHASHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="437" mass="46433" checksum="0901A605CC576018" modified="2017-01-18" version="1">MAATLKSGSSALKLAVVGGGSTYTPELIDGFARLRDTLPIGELVLIDPAAERLELIGGLARRIFAKQGHPAAVSVTTDLTAGVADADAVLLQLRVGGQAARNQDETWPLECGCVGQETTGAGGLAKALRTVPVVLGIAEQVRRTNPDAWIVDFTNPVGIVTRALQSAGHKAVGLCNVAIGFQRKFAAHLGVDPELVRLDHVGLNHLTWERGVTLLDAPGATSGREVLPTLLADFGKEIADDLHLPQAFVQRLGVVPSYYLRYFYQHDAVVEELLAQGSRAAQVAEIERQLLELYADPALDTKPELLGKRGGAFYSEAAVQLISALLGTAGGASVQVVNTRNDGVLPFLPDDAVIEVPAEVDADGVRPLPQRPVEPLFAGLISAVTSYEHLALDAALHGGRDRVFDALLAHPLVGRIELADQLTDRLLAHNREHLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWU9</accession>
    <name>A0A1E7MWU9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0039520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000078">
        <property type="protein sequence ID" value="OEV32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289928.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000062_gene98"/>
    <dbReference type="EnsemblBacteria" id="ARF80107">
        <property type="protein sequence ID" value="ARF80107"/>
        <property type="gene ID" value="B6264_15335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32894">
        <property type="protein sequence ID" value="OEV32894"/>
        <property type="gene ID" value="HS99_0039520"/>
    </dbReference>
    <dbReference type="OMA" id="DVEVCHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020048">
        <property type="entry name" value="NADPH-dep_FMN_reduc_SsuE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03567">
        <property type="entry name" value="FMN_reduc_SsuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="184" mass="19205" checksum="110440806D29C843" modified="2017-01-18" version="1">MATVLSVSGSPSATSRTTRLLRHVDARLVDRGHHVIPFEARSLPAHALLSGDFEHPEIAAVTELFARADGVVIGTPVYKAAYSGLLKALLDVLPQYALAGKAVLPLATGGSPAHVLAVDYALRPVLSSMGAGHITQGWFVLDRHITAAEDGTTLVECETDAQLVPVVAGFADALERLAAPVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX28</accession>
    <name>A0A1E7MX28_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcp</name>
        <name evidence="12" type="ORF">HS99_0014045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552483.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5711"/>
    <dbReference type="EnsemblBacteria" id="ARF81408">
        <property type="protein sequence ID" value="ARF81408"/>
        <property type="gene ID" value="B6264_23075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32992">
        <property type="protein sequence ID" value="OEV32992"/>
        <property type="gene ID" value="HS99_0014045"/>
    </dbReference>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="214" mass="22287" checksum="85A5F0E02376AD00" modified="2017-01-18" version="1">MARALITGFEPFDGADVNPSWEVARLVADTPPDGLLVTPIRLSCVFGQAAEELRAAVREFTPDLVVCLGQAAGRPDVTVERVAINVDDARIPDNAGRQPVDQPVAPGGPAAYFSTLPVKACVAAVRQAGVPASLSHTAGTFVCNHVFYALMHLLATELPTVRGGFVHIPALPEQALDGSKPSLPADAVAHALRALLTAAATHTADLRVPEGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXC5</accession>
    <name>A0A1E7MXC5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0014490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387063.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000648.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5621"/>
    <dbReference type="EnsemblBacteria" id="ARF81485">
        <property type="protein sequence ID" value="ARF81485"/>
        <property type="gene ID" value="B6264_23520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33069">
        <property type="protein sequence ID" value="OEV33069"/>
        <property type="gene ID" value="HS99_0014490"/>
    </dbReference>
    <dbReference type="OMA" id="PANVSHH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="204" mass="22760" checksum="B3C9A2E9F182F636" modified="2017-01-18" version="1">MDDTTGRTPGTTDDPRGAREIQDSRVLAALTHPLRRRLIDVLKVDGPATVGKLAERTEQAVGNVSHHLKVLAESGLIEEAPGLARDRRERWWRLADRELSWTRAHFDGDPVTEAVADAAGSILLERQVELVREWAVRRGGYGPDWRDGTSVATQAWLRLTPEEARELAADLHEVIQKWAHRPVPEDGQDRETVLAFAHSVPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXH2</accession>
    <name>A0A1E7MXH2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552567.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000763.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5781"/>
    <dbReference type="EnsemblBacteria" id="ARF81343">
        <property type="protein sequence ID" value="ARF81343"/>
        <property type="gene ID" value="B6264_22715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32933">
        <property type="protein sequence ID" value="OEV32933"/>
        <property type="gene ID" value="HS99_0013695"/>
    </dbReference>
    <dbReference type="OMA" id="YGMAPDW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="674" mass="72912" checksum="392C0A2C2AAFADBB" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXI1</accession>
    <name>A0A1E7MXI1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0013935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386173.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000246.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5733"/>
    <dbReference type="EnsemblBacteria" id="OEV33147">
        <property type="protein sequence ID" value="OEV33147"/>
        <property type="gene ID" value="HS99_0013935"/>
    </dbReference>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="34216" checksum="1E9C9DE6A4B51C4A" modified="2017-01-18" version="1">MRAAMAAAEVGDDTLGDDPTVIRLERMLADAFGFTGALFLPSGVMANQLALRLLVPPGQELLADAGAHFLLYEDGGVAWHGGILTRTTVSDDGLIDPEVLARMIRPATAYGSGTRAVAVENTHNAAGGVVYPLAALREIRRITREAGVAVHCDGARLWNAHVASGVSFEAYGACFDTLSLCVSKGLGAPAGTVLLLDADRLEEARVMRHRMGGSMRQTGILAAAAIYAFEHNIGRMAEDHSNAALIAGLLRDSGLEVREPQTNLVFVEVPDAAKVQELCATAGVRVSVMGPRTVRLVAHLDVDKQQCERAALTVAKAVAQLATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXS6</accession>
    <name>A0A1E7MXS6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0039005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000070">
        <property type="protein sequence ID" value="OEV33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554175.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene172"/>
    <dbReference type="EnsemblBacteria" id="OEV33247">
        <property type="protein sequence ID" value="OEV33247"/>
        <property type="gene ID" value="HS99_0039005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11840" checksum="707C768EDBD12E5A" modified="2017-01-18" version="1">MAQQLALSVDFGSGFTQAWSKIAKVIPQFIAFLVILAIGWIVAKAIAGVLDRVLRRLGSERVAERAGMARYLSGSKYDMTGIICKIVYYTIRPCSRTSQQIAVSRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXW6</accession>
    <name>A0A1E7MXW6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000068">
        <property type="protein sequence ID" value="OEV33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030291344.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6790"/>
    <dbReference type="EnsemblBacteria" id="OEV33290">
        <property type="protein sequence ID" value="OEV33290"/>
        <property type="gene ID" value="HS99_0038900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19273" checksum="1CF31FABF5F48A2A" modified="2017-01-18" version="1" fragment="single">TSAKIVIAGGFGVGKTTLVGAVSEINPLRTEAVMTSASAGIDDLSHVSGKTTTTVAMDFGRITLDEDLILYLFGTPGQDRFWFMWDDLVRGAIGAVVLVDTRRLADCFPALDYFENSGLPFVVALNGFDGHQPHTAEEVREALQLGAETPVITLDARRRDSAKSALITLVEHALLARLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY01</accession>
    <name>A0A1E7MY01_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0038795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556878.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3282"/>
    <dbReference type="EnsemblBacteria" id="ARF80296">
        <property type="protein sequence ID" value="ARF80296"/>
        <property type="gene ID" value="B6264_16510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33299">
        <property type="protein sequence ID" value="OEV33299"/>
        <property type="gene ID" value="HS99_0038795"/>
    </dbReference>
    <dbReference type="OMA" id="TSAYDPM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="761" mass="79727" checksum="16FC9B978776BBB5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY54</accession>
    <name>A0A1E7MY54_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287655.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000686.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4018"/>
    <dbReference type="EnsemblBacteria" id="ARF80477">
        <property type="protein sequence ID" value="ARF80477"/>
        <property type="gene ID" value="B6264_17570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33375">
        <property type="protein sequence ID" value="OEV33375"/>
        <property type="gene ID" value="HS99_0012345"/>
    </dbReference>
    <dbReference type="OMA" id="LIAWCRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="246" mass="25494" checksum="F7EB9996B8D5DF81" modified="2017-01-18" version="1">MDRTPRLYALVEELRAAAPRPLTVAALAARFEVSTRTVQRDLQALMTAGVPVRTITGRGGGWSIDPAMTLPPIRFTPEEASALVTALAAADASAPYAGAARTASQKITASMSGPASTAARDLAARIVALPARSAESVRTAVERALTESTVLRLSYLDAVGRESDRLVEPAGLLTADGKWYLIAWCRTRQAGRGFRLDRITAAAPTGEPAPPHDLSALLLGSTAAGAVRPAALGALVAPGVSGPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYC0</accession>
    <name>A0A1E7MYC0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553424.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3965"/>
    <dbReference type="EnsemblBacteria" id="ARF80523">
        <property type="protein sequence ID" value="ARF80523"/>
        <property type="gene ID" value="B6264_17850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33419">
        <property type="protein sequence ID" value="OEV33419"/>
        <property type="gene ID" value="HS99_0012625"/>
    </dbReference>
    <dbReference type="OMA" id="TWIFQIM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="409" mass="43103" checksum="114D7685FFEC005D" modified="2017-01-18" version="1">MAHPLTALRRAAEKVDAKTPATRDRALDGLRALALLSVPIGHWMLGGLTLSPDGALHNASPLSSLGFFAPASWVLQMLGVFFLVGGHSSVRSLERAREKGLPYGSWLRARTVRLLRPVLGVTAVWALLIPLLPRLGVPADTLRTGATLVVQPLWYIGVYLALTALTPLCAAFGRRLGLWSAGLLVAAVAVVDLLRYGPWAEAVPSWVGLLNLLPGWMFGYQLGVLWAQGRLGRPAARALLLGGGALFAALLVVFHYPASMVGVPGAERTNSHPPSLLVLALAAVQCGAAVLLRERLGRLLSRRPLLWLPVVVVNLSAMTIFCWHQSAMLAVAVPGAAGLGALPGLTTAPDSLGWVAARLALLPLFGAALVAIGWFARRFDGPWTAFSRIGKALAGAAAALFAAYALGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYI3</accession>
    <name>A0A1E7MYI3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0013105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030549916.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000252.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5168"/>
    <dbReference type="EnsemblBacteria" id="ARF80601">
        <property type="protein sequence ID" value="ARF80601"/>
        <property type="gene ID" value="B6264_18325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33497">
        <property type="protein sequence ID" value="OEV33497"/>
        <property type="gene ID" value="HS99_0013105"/>
    </dbReference>
    <dbReference type="OMA" id="AGWCQTD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="360" mass="36755" checksum="3C51A81F4CE5AD63" modified="2017-01-18" version="1">MRAAVLHETGQDTLDVREDVTAVGFGPGTVRVRMRAAGLCHSDLSAMSGVLPQPAPFVPGHEGAGDVVEVGEGVTGVAPGDRVVLCWMAPCGRCAHCERGRGHLCVASLRRLGAPGFRLAEGDTEASGFYGTGAFAEEVVVAADAVIKVPADLPYEAAALIGCGVTTGIGAAVNTARVEPGATVAVIGAGGVGMATVQGARVCGAARITVVDPVASRRERAPGFGATEAIAPEELKAAAKGLPGGGFDYVFEAVGRAATVRAGYDAARRGGAVVVIGAGAQDDLAQFTMGELFFNEKRLLPSLYGGAPVARTIAMVVDLWRAGRIDLDGMITHRVGLADVNRAIEQMRSGEALRTVVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYK7</accession>
    <name>A0A1E7MYK7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prokaryotic metallothionein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282521.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5179"/>
    <dbReference type="EnsemblBacteria" id="ARF80608">
        <property type="protein sequence ID" value="ARF80608"/>
        <property type="gene ID" value="B6264_18375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33504">
        <property type="protein sequence ID" value="OEV33504"/>
        <property type="gene ID" value="HS99_0013155"/>
    </dbReference>
    <dbReference type="OMA" id="FEVHAQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="9231" checksum="876F5A671A350D38" modified="2017-01-18" version="1">MATCVTCGNDYWLAFEIKTVTGDTYTFDSFECAMEKLAPRCEQCHVRIVGHGVEVAGMFFCCANCARVNGGLGEQIRDAVGSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC6</accession>
    <name>A0A1E7MZC6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289112.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000794.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3779"/>
    <dbReference type="EnsemblBacteria" id="ARF78395">
        <property type="protein sequence ID" value="ARF78395"/>
        <property type="gene ID" value="B6264_05200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33769">
        <property type="protein sequence ID" value="OEV33769"/>
        <property type="gene ID" value="HS99_0037805"/>
    </dbReference>
    <dbReference type="OMA" id="SQWLAWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="20534" checksum="E31891589605D3D1" modified="2017-01-18" version="1">MFSVPLAENAELRPLEPWQAPEFLAHIDRARAHTDPWIPWATFSTDLDSARATLQRYADRQATDSGRIFGIWRDGTLVGGVMFVHFDTKSGNCEIGAWTEPAGEGGGLITAAVRLLLDYAFATRGMHRAEWWCSAANARSRAVAERVGMRREGVLREWFLHNGVRHDKEIWAVLASEWAATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZH1</accession>
    <name>A0A1E7MZH1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0037685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000057">
        <property type="protein sequence ID" value="OEV33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030283741.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000377.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000085_gene4533"/>
    <dbReference type="EnsemblBacteria" id="ARF80390">
        <property type="protein sequence ID" value="ARF80390"/>
        <property type="gene ID" value="B6264_17060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33811">
        <property type="protein sequence ID" value="OEV33811"/>
        <property type="gene ID" value="HS99_0037685"/>
    </dbReference>
    <dbReference type="OMA" id="FWPVPMT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="19961" checksum="2335FA57F0C41524" modified="2017-01-18" version="1">MATATTPIARRAVLADLLPTASTRLGAQARDLALVAGGAALTGVAAQLSVNIPGSPVPVTGQTFAALLVGTALGARRGVASLALYLLAGMAGLPWFAEGTSGWAMPSLGYVLGFVLAAALTGALARRGADRTPVNTAVTMVLGSLAIYAVGVPYLALSLHVSLARAAELGLYPYLVGDALKAAFAAGALPLAWKLLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM1</accession>
    <name>A0A1E7MZM1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282157.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6390"/>
    <dbReference type="EnsemblBacteria" id="ARF78739">
        <property type="protein sequence ID" value="ARF78739"/>
        <property type="gene ID" value="B6264_07245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33882">
        <property type="protein sequence ID" value="OEV33882"/>
        <property type="gene ID" value="HS99_0037400"/>
    </dbReference>
    <dbReference type="OMA" id="DLPWKGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="31491" checksum="D878229EAB510A5D" modified="2017-01-18" version="1">MSQWTIDGPGRTIFEDAVRALHVRVIDGTVNVVAAEGPARLEVTGLKGEALHVTLVDGVLTVTYKDINSWGEFGDWIKSVGSVRNFFDSFKRKRSVDVTLTVPAGTDVKVGTVSAHSTVTGVVGHVSVQAASGDTTLAGVTGRIDASTVTGDVDAQAVGGQLKVNTVSGQLTVIAGTADRVQANTVTGAVTLDLDVAGETDVKVNTVSGPVVVRIPSLADATVEAGSTSGDVSSTFDELKMSSTWGAKKISGQLGEGRGSLNVTTVSGAVTVLRRPDTEDDAPVVAKELPASPGDDRPAGPDLTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS0</accession>
    <name>A0A1E7MZS0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0038205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000060">
        <property type="protein sequence ID" value="OEV33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386109.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000222.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene1926"/>
    <dbReference type="EnsemblBacteria" id="ARF79615">
        <property type="protein sequence ID" value="ARF79615"/>
        <property type="gene ID" value="B6264_12470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33713">
        <property type="protein sequence ID" value="OEV33713"/>
        <property type="gene ID" value="HS99_0038205"/>
    </dbReference>
    <dbReference type="OMA" id="RWWPPLD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="153" mass="15859" checksum="539A83BBCAE153B9" modified="2017-01-18" version="1">MDEATQVPGGLERRECLSLLAGTGYGRVVFTARALPVVAPVNYLLDEDVVVGAGADARLQRLTDGDVVLFEAEGADSGTAWSVSVTGYAHPVTDAGEADRLISRTGSETPWVPGPAESLLRITTTQVDGRTFPITGAGPGRAPLPYPGPTPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZZ0</accession>
    <name>A0A1E7MZZ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289139.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3763"/>
    <dbReference type="EnsemblBacteria" id="ARF78411">
        <property type="protein sequence ID" value="ARF78411"/>
        <property type="gene ID" value="B6264_05280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33783">
        <property type="protein sequence ID" value="OEV33783"/>
        <property type="gene ID" value="HS99_0037885"/>
    </dbReference>
    <dbReference type="OMA" id="ASLHAWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="239" mass="24670" checksum="3842C01266A8F8CC" modified="2017-01-18" version="1">MARNVVVTGGGTGIGYEIARRFAEAGDQVVIVGRRRAVLEKAAADLGPNATPLVCDLADPDAVEAALADLPDRIDVLVNNAGSRETVVGGGTHALLARWRGDFERNVMTAVLLTESIRDRLTPGSGRVVTISSIAALRGAGSYGAAKASLHAWNHFLAAQLGTSGITANIVAPGTVAGTEFFGPRLDEAEVARRAARTLLGRIGETGEVAAAVHFLASPEAGFITGEILHCNGGELLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N038</accession>
    <name>A0A1E7N038_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000056">
        <property type="protein sequence ID" value="OEV33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386227.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000268.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000076_gene4410"/>
    <dbReference type="EnsemblBacteria" id="ARF80327">
        <property type="protein sequence ID" value="ARF80327"/>
        <property type="gene ID" value="B6264_16695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33833">
        <property type="protein sequence ID" value="OEV33833"/>
        <property type="gene ID" value="HS99_0037475"/>
    </dbReference>
    <dbReference type="OMA" id="CVAMFTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="291" mass="31115" checksum="EB79B49A4DEB91F8" modified="2017-01-18" version="1">MLPSSFQAARALATTRVLEPPDLADALAILHRDPVANAFVATRVEAVGLDPWRLGGEMWGWYDGNGVLDALCYAGANLVLVDAGPQAVAAFAERARRQGRRCSSIVGPAGSTAAFWALLERSWGPAREVRGHQPLLATSSPSAEIAPDPLVRRVRRDEVEALMPACVAMFTEEVGVSPLAGDGGLLYQARVAELVTTGRSFARFAEDGQVVFKAEIGAVTEGACQIQGVWVAPEYRGQGLSETGMAAVLDVALREVAPVVSLYVNDFNLRARAAYRRVGFREVGAFMSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1A9</accession>
    <name>A0A1E7N1A9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78937">
        <property type="protein sequence ID" value="ARF78937"/>
        <property type="gene ID" value="B6264_08420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34464">
        <property type="protein sequence ID" value="OEV34464"/>
        <property type="gene ID" value="HS99_0035775"/>
    </dbReference>
    <dbReference type="OMA" id="RDRIGFM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="28799" checksum="31513FE8417F8EA9" modified="2017-01-18" version="1">MGVRIREPARSTPVTTSTATAVHTGLAAARATGLNKVYGEGETRVVALDNVSVTFPQGEFTAIMGPSGSGKSTLMHCMAGLDTVSSGSTTIGDTELVGLKDKQLTQLRRDHIGFIFQAFNLLPTLTALENITLPMDIAGRKADQAWLDRVVDTVGLSGRLGHRPSQLSGGQQQRVACARALAGKPDIIFADEPTGNLDSRSGAEILSFLRNSVRELGQTVVMVTHDPVAASYADRVVFLADGRIVDELHAPTADTVLDRMRRFEAKGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1N8</accession>
    <name>A0A1E7N1N8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0008835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558161.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000531.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF82039">
        <property type="protein sequence ID" value="ARF82039"/>
        <property type="gene ID" value="B6264_26960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34597">
        <property type="protein sequence ID" value="OEV34597"/>
        <property type="gene ID" value="HS99_0008835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="183" mass="19743" checksum="B37D0250AF96589D" modified="2017-01-18" version="1">MDVLPELLAALPALDAGLDPAAPWPLRRVELRVPEGVTVHIGDPQGSDGYAIEVPQIVAYLVLDADPDEPEITAALLRLDDAYPVGMDEDVEFLDTFTGVLLVHALADNRSAVRFAQDFAEAGDRRHEVNPGAEATGRTGKPSESWQLEPDGPVLALRVNQEGMNVFTCRDAQGRNVGMLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N248</accession>
    <name>A0A1E7N248_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0009685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555863.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000356.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4613"/>
    <dbReference type="EnsemblBacteria" id="OEV34745">
        <property type="protein sequence ID" value="OEV34745"/>
        <property type="gene ID" value="HS99_0009685"/>
    </dbReference>
    <dbReference type="OMA" id="DWLAQWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="140" mass="15039" checksum="0A2D3F1D205A3CB4" modified="2017-01-18" version="1">MTTSAGAGKLPDGYNPNRDAASDLQAALALSAGDQRPVLIDFGANWCPDCKVLDKLFRSEQVAPLLRDDYRVVAVDVGRFDHNLDLAAQYVDLQRSGIPALVVLSPDGAVRTASNDGAFSNARSMTANTVAAYLKRWSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2J7</accession>
    <name>A0A1E7N2J7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0034960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000042">
        <property type="protein sequence ID" value="OEV34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000028_gene5869"/>
    <dbReference type="EnsemblBacteria" id="ARF77545">
        <property type="protein sequence ID" value="ARF77545"/>
        <property type="gene ID" value="B6264_00135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34914">
        <property type="protein sequence ID" value="OEV34914"/>
        <property type="gene ID" value="HS99_0034960"/>
    </dbReference>
    <dbReference type="OMA" id="WAPLVPY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="440" mass="43571" checksum="D3AC39C797D9F541" modified="2017-01-18" version="1">MPVRNKIRSHRHTDESSSQSRSTTLAPDRPWGAARLALTAFFAVDGFLFAAWVVRIPDIRSQVSASHSALGLALLCLSIGAVLTMPVVGRLCLRYGSRPVTVGSLALLGLAVPLPAHAHSVLSLGAVLLLFGAGYGGANVAMNSAAVDLVAQLRRPVMPSFHAGYSLGGLVGAGFGGLLADRLTTAWALALGGLLGLAVTVGAGIVLLRSPAAPMVAPERGGDGSAAGSAADAGGGSDRGSGEGGVAMGPAENSTVRPTGAPVRLLVLMLGFTALCTAYGEGAIADWTTLHLTDDVHASAGTAAAGYAAYAFAMTSGRVGGTWLSIRLGQNRLMLLGGLTAAAGMLVAALAPAVPLAIGGFILVGLGLANLFPLAIARAGAAGGPQGVALASTLGYGGMLIGPVVIGFLADAAGLPLALTTVAVAATTAALLPFAVGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N314</accession>
    <name>A0A1E7N314_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0034410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043480725.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000360.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4707"/>
    <dbReference type="EnsemblBacteria" id="OEV35065">
        <property type="protein sequence ID" value="OEV35065"/>
        <property type="gene ID" value="HS99_0034410"/>
    </dbReference>
    <dbReference type="OMA" id="TRIADFY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="131" mass="13930" checksum="A9CA285678A510E1" modified="2017-01-18" version="1">MTDTDTDAGTAARSGSPDSAVDRVADFYGAYVDAVADGTDDLSDELRGHYLTEDLRQRLAAWEEVNHADGVLRAQDVPTAWEVAYQDAGAGHLFTTVTLTWGTGPDAGTTRLAVQSDLSTKLISDIEDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N337</accession>
    <name>A0A1E7N337_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multidrug MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0034175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554295.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000331.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene389"/>
    <dbReference type="EnsemblBacteria" id="ARF78911">
        <property type="protein sequence ID" value="ARF78911"/>
        <property type="gene ID" value="B6264_08265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35108">
        <property type="protein sequence ID" value="OEV35108"/>
        <property type="gene ID" value="HS99_0034175"/>
    </dbReference>
    <dbReference type="OMA" id="WINGPIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="528" mass="53101" checksum="98597D50344B55D0" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3H5</accession>
    <name>A0A1E7N3H5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289470.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1363"/>
    <dbReference type="EnsemblBacteria" id="ARF79283">
        <property type="protein sequence ID" value="ARF79283"/>
        <property type="gene ID" value="B6264_10455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35222">
        <property type="protein sequence ID" value="OEV35222"/>
        <property type="gene ID" value="HS99_0033420"/>
    </dbReference>
    <dbReference type="OMA" id="EHWNTLR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="118" mass="12566" checksum="09625D3C462E167B" modified="2017-01-18" version="1">MSRLGGPALRLTVLVGESDTWHHRPLYSEIVHRARAAGLAGASVFRGIEGFGASSLVHTARLLSLSEDLPVAVVIVDEEDRVRAFLPQLEELVAEGLVLLDRCEVVHYRGRGAGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4E5</accession>
    <name>A0A1E7N4E5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0033230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550033.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000817.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5339"/>
    <dbReference type="EnsemblBacteria" id="OEV35333">
        <property type="protein sequence ID" value="OEV35333"/>
        <property type="gene ID" value="HS99_0033230"/>
    </dbReference>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="323" mass="35096" checksum="8699260D7D18ADD0" modified="2017-01-18" version="1">MGLPELAAVVDRVRANVESVIEGKPEAVRIALTVLLAEGHLLLEDVPGVGKTMLAKALARSVDCTVRRIQFTPDLLPSDVTGTNIYDQQRHDFEFRPGAIFAQIVVGDEINRASPKTQSALLESMEERQVTIDGTSYELPSPFMVVATQNPVEMEGTYPLPEAQRDRFMARISIGYPSPEAEFAMLDVHGGANPLDDLQPVAHAADILKLVELVRTVHIADPVRRYAVDLVGATRTSPELRLGASPRATLHLVRAARAAAALDGRDYVTPDDIQRLAVPVLAHRLMPTAETQLGRRSAEQIVTDLVARLPLPRPQGGPAGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4J3</accession>
    <name>A0A1E7N4J3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280385.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000790.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5366"/>
    <dbReference type="EnsemblBacteria" id="ARF80768">
        <property type="protein sequence ID" value="ARF80768"/>
        <property type="gene ID" value="B6264_19305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35574">
        <property type="protein sequence ID" value="OEV35574"/>
        <property type="gene ID" value="HS99_0006540"/>
    </dbReference>
    <dbReference type="OMA" id="GLERRSH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="123" mass="13657" checksum="4F00D5CE653C26A8" modified="2017-01-18" version="1">MTTAGAPAVKVLPEPADLPAPLPEPGIDELRLETVLGALSDPLRLTIVRKLLLESEDFDHSCGWFGLDRPKSSLTHHFRALREAGITRQRQYGLERRSHVRVEDLDARFPGLLDLVAAWTPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4L2</accession>
    <name>A0A1E7N4L2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281853.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF80823">
        <property type="protein sequence ID" value="ARF80823"/>
        <property type="gene ID" value="B6264_19640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35629">
        <property type="protein sequence ID" value="OEV35629"/>
        <property type="gene ID" value="HS99_0006870"/>
    </dbReference>
    <dbReference type="OMA" id="IAHPAFF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="242" mass="26389" checksum="F45357D8E803EDF8" modified="2017-01-18" version="1">MRFDDHRVVITAAGRDFGRTLAIRLADLGAEVFLSARTLAAAERVRDEIRDRGKQRVHAFACDLTDPASIRDFAARVGGQTDHIDVLINNGSRYLAGPDLLSASDADVVDTIASGATGTVLTVKNFLPLLLNSVKPDVVTMVSACGTPGHHRSDAHDSFYAAKNAQAGFVDILSKRLRPRGVRVISLYPPDFDNPDPLAEEWETTPRHARAPLAAQSLVECVLFAVSQPRDCFIKAFHFEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4R0</accession>
    <name>A0A1E7N4R0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene894"/>
    <dbReference type="EnsemblBacteria" id="ARF80877">
        <property type="protein sequence ID" value="ARF80877"/>
        <property type="gene ID" value="B6264_19930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35679">
        <property type="protein sequence ID" value="OEV35679"/>
        <property type="gene ID" value="HS99_0007160"/>
    </dbReference>
    <dbReference type="OMA" id="QHFLVGS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="325" mass="33429" checksum="E004EA9B6CF43029" modified="2017-01-18" version="1">MVAIAAAALLGTAGTLPAAAAAHRPTPAVIVGHAPTLVPEAGVWDASHHRFLLGSLRHGTVSAVALDGSVRTLVQDPALTEIAGLRIDPVHRRVLVTDLDNGIGERSTAATLGKIAGIGAYDLDTGRRLFYTDLATVAGDGGSHLANDIAVAPDGTAYVTDSFAPVVYRVTPDGTASVLLRDPRLTPAPGTYGLNGIVYREGHLILGKWDDGTLWRVPLGNPAALRRVEVAGGASLLHLDGLLGRPDGTIAGVTNALFGAGRDAELELRSDDHWRTARLTAVHPSPDTTPTAPVAGPAGSLYLLSGGLAAAASGHPTDAFTLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4U8</accession>
    <name>A0A1E7N4U8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551082.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000439.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene843"/>
    <dbReference type="EnsemblBacteria" id="ARF80918">
        <property type="protein sequence ID" value="ARF80918"/>
        <property type="gene ID" value="B6264_20190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35716">
        <property type="protein sequence ID" value="OEV35716"/>
        <property type="gene ID" value="HS99_0007420"/>
    </dbReference>
    <dbReference type="OMA" id="VEAGQMY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="10773" checksum="5AD0FA066D4DD8C0" modified="2017-01-18" version="1">MSLVDLRECAAQLPDAWRSVVLGRVGTTAVKVLRMDGRELEQEVHGTAEVLFVADGVLELDVEGEALTVGAGELCQVPAGARHAVRPGSRGTLLIVEVPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4V1</accession>
    <name>A0A1E7N4V1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene831"/>
    <dbReference type="EnsemblBacteria" id="ARF80930">
        <property type="protein sequence ID" value="ARF80930"/>
        <property type="gene ID" value="B6264_20255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35727">
        <property type="protein sequence ID" value="OEV35727"/>
        <property type="gene ID" value="HS99_0007485"/>
    </dbReference>
    <dbReference type="OMA" id="ETLRWWD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="620" mass="66971" checksum="EA7CF45C36F5C4CF" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5G7</accession>
    <name>A0A1E7N5G7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0007315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281656.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000151.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene863"/>
    <dbReference type="EnsemblBacteria" id="ARF80905">
        <property type="protein sequence ID" value="ARF80905"/>
        <property type="gene ID" value="B6264_20090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35703">
        <property type="protein sequence ID" value="OEV35703"/>
        <property type="gene ID" value="HS99_0007315"/>
    </dbReference>
    <dbReference type="OMA" id="YVELMFA"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008223">
        <property type="entry name" value="Urease_gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001225">
        <property type="entry name" value="Urease_gammabeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="236" mass="24537" checksum="682A7725B0295FFE" modified="2017-01-18" version="1">MRLTPTERDRLLIFTAAELARARRARGVRLNIPEATALIADTVCEAARDGRRLAEAIEAGRSVLTADDVLPGVPDVVTVVQVEAVFDDGTRLAVVNDPFKGAGSLGDEAPGGALVGDGAGYDPIEETLLLPVHNTSAVPISVTSHFHFFEANPRLAFDRAAAYGTHLAVPAGSSVRFDPGTTVEVGLVPIGGDRVAIGFAGLVDGPLDAPGAKEAALEKARATGYLTNFDDSEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5H8</accession>
    <name>A0A1E7N5H8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551154.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene912"/>
    <dbReference type="EnsemblBacteria" id="ARF80859">
        <property type="protein sequence ID" value="ARF80859"/>
        <property type="gene ID" value="B6264_19840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35945">
        <property type="protein sequence ID" value="OEV35945"/>
        <property type="gene ID" value="HS99_0007070"/>
    </dbReference>
    <dbReference type="OMA" id="FEPAMIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016259">
        <property type="entry name" value="Hygromycin-B_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000707">
        <property type="entry name" value="Hygromycin-B_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="48"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="307" mass="33469" checksum="92D6B1DE886C55DB" modified="2017-01-18" version="1">MLPPVETDEQWDAVVPDESVMRPGAEALCARLGLGGRPLTRFAEGSVPVYAVGEEHVLKLFPAASAGDGLAEQRVLTFLEGALPIPTPAVRAAGEYVNGWRYVLMSRLHGEGLAPAWPRIPRAGRERIARDCGEALAALHSLDAAPLAGALAPGDWPAFLARQRAGAVDRQRERGLPAAWLEQIPGFLAATPLPTAPQRSLLHTEFMREHLIADPTGHWRLTGLIDFEPAMIGDPAYDLVAVGLFTTRADPQLLGQLLTAYGRPFEPRLLMAYTLLHVYSNLPWYLRELRPSARTLDGLAEEWFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J3</accession>
    <name>A0A1E7N5J3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0007145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene897"/>
    <dbReference type="EnsemblBacteria" id="OEV35949">
        <property type="protein sequence ID" value="OEV35949"/>
        <property type="gene ID" value="HS99_0007145"/>
    </dbReference>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV35949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="486" mass="51329" checksum="0AE6363670083A79" modified="2017-01-18" version="1">MDLPKAILSALTREGVTEPFPIQAATLPDSIAGRDVLGRGRTGSGKTLAFGLPLLARTAGRRADSRHPLALVLVPTRELAQQVTEALTPYATAVNLRITTVVGGMGISRQANAVRRGTEVLVATPGRLDDLIGRGDVNLSDVAITVLDEADQMADMGFLPQVSKLLEQVAEGGQRMLFSATLDRNVDRLVKRFLTDPVTHSVDPSAGAVTTMDHHVLQLEPTDKASATAHIASRDGRVIMFVHTKHGADRLAKQLRATGVMAAALHGGKSQPQRNRVLDQFRDGEVTALIATNVAARGIHIDGLDLVVNVDPPIDHKDYLHRGGRTARAGESGTVVTLVLPEQRREVNRLMTVAGIRPTVTRIRPGDADLARITGARTPSGVPVALAVPAAAQPAAQAASADGKGADGKSGSPRRRPGKRSGLPTDVDMNGNPRRPRPKQRLGAAGQGERPQAAGFIGRSSGRARPGSGSKSGGNYGTGRQRRKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N613</accession>
    <name>A0A1E7N613_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553195.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5017"/>
    <dbReference type="EnsemblBacteria" id="ARF80082">
        <property type="protein sequence ID" value="ARF80082"/>
        <property type="gene ID" value="B6264_15190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36137">
        <property type="protein sequence ID" value="OEV36137"/>
        <property type="gene ID" value="HS99_0031210"/>
    </dbReference>
    <dbReference type="OMA" id="RMRDYTE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="9578" checksum="760A9E78F490AE3C" modified="2017-01-18" version="1">MTRDPIAPEDPRMRDYTETQITSLLGELHRRRLPHGLLWGSAAPGEKTLDGRILIDFGNSPVSTLLNLLHLLRDLERDEPWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N633</accession>
    <name>A0A1E7N633_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0031220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000030">
        <property type="protein sequence ID" value="OEV36139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000018_gene5021"/>
    <dbReference type="EnsemblBacteria" id="ARF80084">
        <property type="protein sequence ID" value="ARF80084"/>
        <property type="gene ID" value="B6264_15200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36139">
        <property type="protein sequence ID" value="OEV36139"/>
        <property type="gene ID" value="HS99_0031220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="89" mass="10370" checksum="0C78117CE46659D2" modified="2017-01-18" version="1">MLDADGVTIWQKYGGRTVEGYYYDGWHKIEPGDPRYDELLPQARENPQDDDDDEDDLDDLDDDGPTVHPETLAMLMDMQRRTTERGEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R3</accession>
    <name>A0A1E7N6R3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HS99_0029940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554780.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7733"/>
    <dbReference type="EnsemblBacteria" id="ARF82328">
        <property type="protein sequence ID" value="ARF82328"/>
        <property type="gene ID" value="B6264_28725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36380">
        <property type="protein sequence ID" value="OEV36380"/>
        <property type="gene ID" value="HS99_0029940"/>
    </dbReference>
    <dbReference type="OMA" id="ADIHYEV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="17" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OEV36380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="393" mass="42046" checksum="E0E94FDA1DD0C48D" modified="2017-01-18" version="1">MLSAKSAEVVEATLPVVGGAIGDITPRFYDRLFAAHPELLRDLFNRGNQANGTQREALAGSIAAFAAALIANPDQRPDAMLARIAHKHVSVGIDNEQYKVVHEHLFAAIVDILGEAVTPEVAAAWDEVYWLMANALMAIEERLRAEVAAGTDQTDLWRPYTVVARHQETDTVTTYLVRPADDGSLPASRPGQYVSVRTELADGAHQIRQYSLSGGADNALRFSVKRDGEVSGHLHDNLHAGDTVELAPPLGDIFLAEGDGPVLLASAGIGNTPMTAMLDHLAATGSARQVISVHGDRDQLSHAFRADLEQLTAKLANATAHVFYEQPLGEWPAERTGLVNLSTVEVPVGTTAYLCGPLPFLRAVRGQLIEAGVPAADIHYEVFGPDLWLGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6T7</accession>
    <name>A0A1E7N6T7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385518.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7742"/>
    <dbReference type="EnsemblBacteria" id="ARF82320">
        <property type="protein sequence ID" value="ARF82320"/>
        <property type="gene ID" value="B6264_28680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36389">
        <property type="protein sequence ID" value="OEV36389"/>
        <property type="gene ID" value="HS99_0029985"/>
    </dbReference>
    <dbReference type="OMA" id="HLLCHAD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="207" mass="21984" checksum="2744EDEDF3CA1450" modified="2017-01-18" version="1">MGLAISVGLLGTPDLREEAEVLHRALAAEGVAWREPATAPAGPAEVFGAGFPYSYLSGLRRVYVLHRLGEPVTGAREVSSEQYDEDLELVDDETAVLDSHLLCHADHEGYYVPAEFPFEDPLFLPEGAGVPGAGMVGSCGPLLAELQRFAAAIGIRLAADGSLAPEESARLDALPGDDPFEPEVFAWHALYRACRTSLATGHAIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N701</accession>
    <name>A0A1E7N701_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554183.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000179.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene179"/>
    <dbReference type="EnsemblBacteria" id="OEV36470">
        <property type="protein sequence ID" value="OEV36470"/>
        <property type="gene ID" value="HS99_0029530"/>
    </dbReference>
    <dbReference type="OMA" id="HWFPFDL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="211" mass="22974" checksum="DD39B68DF6A501F2" modified="2017-01-18" version="1">MQVRPISPDRLAELLADRITALPGSGERWLRVAVDGAGAARPELLADALVEPLRLRGRPALRVSAVDFLRPASIRLEYGHRDADAFHDLWLDDGALLREVLDPLEPGGSGRVLPSLRDPATDRSTRAAYVQLPPGGVLLLDGALLLGRWLPLELTVHLALTPAALARRTPADQQWTLPAFARYEAETGPTEAADVVVRVDDLRHPALVERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N769</accession>
    <name>A0A1E7N769_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F420 biosynthesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288960.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1451"/>
    <dbReference type="EnsemblBacteria" id="ARF79172">
        <property type="protein sequence ID" value="ARF79172"/>
        <property type="gene ID" value="B6264_09785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36525">
        <property type="protein sequence ID" value="OEV36525"/>
        <property type="gene ID" value="HS99_0028795"/>
    </dbReference>
    <dbReference type="OMA" id="QFTAVPW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022454">
        <property type="entry name" value="CHP03883_F420-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03883">
        <property type="entry name" value="DUF2342_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="394" mass="42319" checksum="0C7B7E1D8A060554" modified="2017-01-18" version="1">MTSASGGADMVDWNLAVATATRLVRPGPEVSRAEAAAVVAELRRHALEAEEHVRAFTGMRSSSLAAATATPVLVVDRPGWVRANVAGFRTVVQPLVEKLQARRANSAAAGVFGAVGEKATGIEVGALLAFLATKVLGQYETFAPAEPSLEAPDSPAALFDKPRLGPEGPGPGRLLLVAPNIVHVERELDVDPSDFRLWVCLHEETHRTQFTAVPWLRDHIQSEVQSFLAETDVDPGALLERLRDAAGSLGAGLPGAGNREGRESPSPGNLLELVQSPAQREILGRLTAVMSLLEGHADVVMDGVGPAVVPTVAEIREKFQQRRDRGANRLDLVLRRLLGMDAKLRQYQDGAVFVRAVVEQVGMEGFNRVWTSPNTLPTKDEIHDPAAWVARVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7F0</accession>
    <name>A0A1E7N7F0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0028770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000025">
        <property type="protein sequence ID" value="OEV36599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555381.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000041_gene1456"/>
    <dbReference type="EnsemblBacteria" id="ARF82731">
        <property type="protein sequence ID" value="ARF82731"/>
        <property type="gene ID" value="B6264_09810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36599">
        <property type="protein sequence ID" value="OEV36599"/>
        <property type="gene ID" value="HS99_0028770"/>
    </dbReference>
    <dbReference type="OMA" id="CGAEITR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="181" mass="20113" checksum="D50C981D5FC69582" modified="2017-01-18" version="1">MERLDLEQLRILRRETMEQEADLSYLRRLLHGRMDILRAELDRRPGGGTAHRARSGGYGSGAPAVGGEPGTDLLDLLPAILTDAPSTVRRSARHVTLGPPRTQESQLEADALMGDVQLADLAAHPAEELLAALERLRAHEREVSGRRQRLLRTADGCNAEITRRYRDGEARVEDLLSERPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7K2</accession>
    <name>A0A1E7N7K2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0028370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000024">
        <property type="protein sequence ID" value="OEV36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550705.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2492"/>
    <dbReference type="EnsemblBacteria" id="ARF81509">
        <property type="protein sequence ID" value="ARF81509"/>
        <property type="gene ID" value="B6264_23655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36682">
        <property type="protein sequence ID" value="OEV36682"/>
        <property type="gene ID" value="HS99_0028370"/>
    </dbReference>
    <dbReference type="OMA" id="ISWWVVD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="167" mass="18864" checksum="C1483E57BB593682" modified="2017-01-18" version="1">MTWLPADFVHPVRVPLPGGAHHLRPIRESDAPMDYPAVMGSRERLFGIFGPAWGWPSETMTAEANRVDLARHEREIAAHESFNYVLLDRAETAVRGCVYIDPPERAGADAEISWWVVDELVGSEVEQALDALVPQWIAADWPFRRPRFLGREISWQDWLALPGVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7R5</accession>
    <name>A0A1E7N7R5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0027280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552927.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000799.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4745"/>
    <dbReference type="EnsemblBacteria" id="OEV36730">
        <property type="protein sequence ID" value="OEV36730"/>
        <property type="gene ID" value="HS99_0027280"/>
    </dbReference>
    <dbReference type="OMA" id="NHHMEVS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV36730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="41677" checksum="5025FEBBCD4DC571" modified="2017-01-18" version="1">MSAPSAVFEDGHRELVDAFESFIRRELVPLAAELPETADQVPTDLRAYVRKRSAALGFYAGDYPEELGGADMPFIAVVLLHHAAGRSGCVLAPYALAGSDGPSPLLRHGTPEQVERHLVPLVRGEQTRCLALTEPQAGSDAFHLTTTAVRTGDTWVLNGRKTFVSNAEHAGIALAVAATDLGDGKGPNAGATAFVLPMDQPGLRIGQRYEGMSGEPLFELLLDQVTVGPEAVIGGEEGIGAATALAMDSLSRGRLVVAAMCNGIAEYALKAGVEYARERRAFGKVIGEYQHVQEHLVATRAEVESSKLLTLACARLVDEGTESPENAALAKLTASETAVRAVDRSLQVHGATGWVRGHPLEFLYRYVRMTTIIEGTSEVQKVIIARSMGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N841</accession>
    <name>A0A1E7N841_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0026735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030282042.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000256.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6448"/>
    <dbReference type="EnsemblBacteria" id="ARF78688">
        <property type="protein sequence ID" value="ARF78688"/>
        <property type="gene ID" value="B6264_06950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36866">
        <property type="protein sequence ID" value="OEV36866"/>
        <property type="gene ID" value="HS99_0026735"/>
    </dbReference>
    <dbReference type="OMA" id="HQACTVV"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV36866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20692" checksum="643C308330EF43B5" modified="2017-01-18" version="1">MVNLTRIYTRTGDDGTTALGDMSRTTKTDPRLIAYADANEANAAIGVALAVGALPEDVAAVLVRVQNDLFDVGADLSTPVVEDPKYPPLRVLQSYVDRLEGDCDHYLEQVEKLRSFILPGGTPGAAHLHLACTVVRRAERSTWAAIAEHGDTVNPLTAKYLNRLSDLLFILARVANKERGDVLWVPGENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N879</accession>
    <name>A0A1E7N879_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0026875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281979.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000362.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6477"/>
    <dbReference type="EnsemblBacteria" id="ARF78661">
        <property type="protein sequence ID" value="ARF78661"/>
        <property type="gene ID" value="B6264_06810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36891">
        <property type="protein sequence ID" value="OEV36891"/>
        <property type="gene ID" value="HS99_0026875"/>
    </dbReference>
    <dbReference type="OMA" id="TRYRVMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="112" mass="12095" checksum="414AB85FD6D73ADF" modified="2017-01-18" version="1">MKATPLLGWYRGLAIATGCALLVFCGFMVAKYGFGAAEDLTTYVAMLHGYLYIGYFVVTFLLGQKLKWPLGRLVLTLAAGCIPFLSFVFERKVAREAAEQLPAGGARQPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8E9</accession>
    <name>A0A1E7N8E9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553727.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000429.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6821"/>
    <dbReference type="EnsemblBacteria" id="ARF78616">
        <property type="protein sequence ID" value="ARF78616"/>
        <property type="gene ID" value="B6264_06545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36938">
        <property type="protein sequence ID" value="OEV36938"/>
        <property type="gene ID" value="HS99_0027150"/>
    </dbReference>
    <dbReference type="OMA" id="RHETFRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="462" mass="51507" checksum="E1BDA16AE13FF889" modified="2017-01-18" version="1">MIQASLTQQRLWFLNQLEESNGTWNVPVAVRLRGPVDHDALTTALRRTVIRQSTLRTVFVDVGGVPWQRILEPSEVHVPLEILTAPATRSELAERLTAESLRGFHLAEELPLRARLFILGPQDHVLLLVMHHIAMDGWSLGPLFRDMSAAYRAAIEGREPLWEPLPVEYTDYAEWQRELLGQASDPNSLISRQLLYWKGSLAGIPDEIPLPFDRRRPAVPSRHGAVVPLHLDAELHESLAAMAKRAGASPFMVFHAALAATLTRLGAGHDIPIAVPTAGRVDEALDDLVGFFINTLVVRADTSGDPTFEELLTRVRDAALGAFSHQDVPFDRLVEELNPRRSLSRQAFFQVVLDVTEKGDSTLRLPGVECLDQPVEFPVVRFDMWLGLTELKGPDGECRGVVGELLYSTDLFDRATMQNLVEKFLALLRAAAAEPELRLTSMNSPRKLRAVQRKPVKLQPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8G6</accession>
    <name>A0A1E7N8G6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286979.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6806"/>
    <dbReference type="EnsemblBacteria" id="OEV36969">
        <property type="protein sequence ID" value="OEV36969"/>
        <property type="gene ID" value="HS99_0027225"/>
    </dbReference>
    <dbReference type="OMA" id="KAKGWKH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="83" mass="8718" checksum="88BC08B60FB55E8B" modified="2017-01-18" version="1">MEKAKAQSASLKGFKHSKPGLWLSIGTSAFGAISIVKDARKAREENDTLKLVNALVGAAALITGTALLVRELRQLGSDDVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8R7</accession>
    <name>A0A1E7N8R7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81671">
        <property type="protein sequence ID" value="ARF81671"/>
        <property type="gene ID" value="B6264_24685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37058">
        <property type="protein sequence ID" value="OEV37058"/>
        <property type="gene ID" value="HS99_0004315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="74" mass="8109" checksum="DE4752D092B1896D" modified="2017-01-18" version="1">MGRAFGMTTPTRRHRRGHRPDAFTAAAPARAARPSVPARPRGSGCCRTWSSEHLTPGGTVVRTTWHEPACKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8U2</accession>
    <name>A0A1E7N8U2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0004360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556121.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000394.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7437"/>
    <dbReference type="EnsemblBacteria" id="ARF81665">
        <property type="protein sequence ID" value="ARF81665"/>
        <property type="gene ID" value="B6264_24635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37064">
        <property type="protein sequence ID" value="OEV37064"/>
        <property type="gene ID" value="HS99_0004360"/>
    </dbReference>
    <dbReference type="OMA" id="PLGHHVT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="138" mass="14546" checksum="71DA3722C930DF61" modified="2017-01-18" version="1">MSLALEDRLSVIELVSLHGHLVDDGSLDRLDELFTADVVYDLTDFGQESLSGVAAVREAAWALGAANPVAHHVTNVVVTAGADGRVQVRSKGLGIKADGSCGSVTYDDTVVRTADGWRISCRRVSARRTPLGGMTKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Q3</accession>
    <name>A0A1E7N9Q3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HS99_0005255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558186.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000097_gene46"/>
    <dbReference type="EnsemblBacteria" id="OEV37213">
        <property type="protein sequence ID" value="OEV37213"/>
        <property type="gene ID" value="HS99_0005255"/>
    </dbReference>
    <dbReference type="OMA" id="GDLPWAS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV37213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="284" mass="29919" checksum="050D79A5AB6AF726" modified="2017-01-18" version="1">MTENTGNTPSASRATHSSGRRLLGELSAEFAGTMILILFGVGVVAQVVAGGIGNHDSISWAWGLGVTFGIYTAARISGAHLNPAVTVALAVFKGFDWRKVLPYVLAQTAGAFVAALLVRWNYTEVLNKVDPGHTLKTQVVFSTLPGNGTAPVSDWGALRDQVIGTAILVFLVLAVTDVLNTPPEANLGPFIVGLIVVGIGMAWGTDAGYAINPARDFGPRLASYLTGYSHAWRDQYGHLYFWVPIVGPLIGCLVGGVAYRYLVTPHLGAEGPEEPGQAPIEPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9Z8</accession>
    <name>A0A1E7N9Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388185.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000571.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7988"/>
    <dbReference type="EnsemblBacteria" id="ARF79057">
        <property type="protein sequence ID" value="ARF79057"/>
        <property type="gene ID" value="B6264_09130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37515">
        <property type="protein sequence ID" value="OEV37515"/>
        <property type="gene ID" value="HS99_0026225"/>
    </dbReference>
    <dbReference type="OMA" id="YFCTTII"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="449" mass="47444" checksum="66B09BA50F57B8AD" modified="2017-01-18" version="1">MSTAPEATSSPSVLTRIRKTPFWVQIVAGLVLGVGLGYLARAADVSWLATTLETIGKIFVQLLKLAVPPLVFTAIVVSVANLRNVTNAARLATRTLLWFMITSLIAVGIGLGLGLLTNPGQGTNLKTEGLKALDSKGTWIDFLTGIFPTNIVDAFVKVNVLQIVFLAVVVGAAIIKLGTKADPVLKLSETVLELTQTALWWVIRLSPLGTLGLIGKSVAKYGWDLLKPFATLTLDIYVGCALVLFVVYSLVLRFAAGLNPLHFFKGAWPAIQLAFVSRSSVGTLPVTRRVTERLGVPSEYASFSVPFAATTKMDGCASIYPAVAAIFVAQVYNVELDIKDYILIAFVSVVGSAATAGLTGAIVMLTLTLSTLGLPLEGVGLLLAIDPILDMMRTATNVAGQVVVPIVVAARERILDVAAYNNPSGDLYEEDAPKAVIPVRADAEGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA30</accession>
    <name>A0A1E7NA30_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0026410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1150"/>
    <dbReference type="EnsemblBacteria" id="ARF79028">
        <property type="protein sequence ID" value="ARF79028"/>
        <property type="gene ID" value="B6264_08945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37542">
        <property type="protein sequence ID" value="OEV37542"/>
        <property type="gene ID" value="HS99_0026410"/>
    </dbReference>
    <dbReference type="OMA" id="CAVDYLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="116" mass="11819" checksum="46F705AB1CCCFD2D" modified="2017-01-18" version="1">MGVGLPLVGAVVDEFSGPGMGIVFAVCAVLGTGFAAALSTRRGWWWVLAASPLVVLGVTAAVEFSANSEKYRGNALATGSAKWVVHGFPVMAQAAAAAAVVIVARVVLDRRGQQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAL4</accession>
    <name>A0A1E7NAL4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosine 5-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0025840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280859.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000767.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000026_gene1626"/>
    <dbReference type="EnsemblBacteria" id="ARF79980">
        <property type="protein sequence ID" value="ARF79980"/>
        <property type="gene ID" value="B6264_14630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37722">
        <property type="protein sequence ID" value="OEV37722"/>
        <property type="gene ID" value="HS99_0025840"/>
    </dbReference>
    <dbReference type="OMA" id="AARRDYM"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="375" mass="40010" checksum="BE62FAD217657336" modified="2017-01-18" version="1">MTEIEIGRGKRGRRAYAFDDIAVVPSRRTRDPKEVSIAWQIDAYRFELPFLAAPMDSVVSPQQAIAIGRLGGLGVLNLEGLWTRYEDPQPLLDEIVSMTDAAAATRRLQEIYAAPIRAELIKQRIQEVRDSGVVTAAALSPQRTAEFSKAVVDAGVDVFVIRGTTVSAEHVSSAAEPLNLKQFIYELDVPVIVGGCATYTAALHLMRTGAAGVLVGFGGGAAHTTRNVLGIQVPMATAVADVAAARRDYMDESGGRYVHVIADGGVGYSGDIPKAVACGADAVMIGAALARATDAPGKGFHWGMEAVHEELPRGKRMDLGTVGTTEEILTGPSHTPDGTMNLFGALRRAMATTGYTELKEFQRVEVTVNPALDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAS4</accession>
    <name>A0A1E7NAS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0024675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF78077">
        <property type="protein sequence ID" value="ARF78077"/>
        <property type="gene ID" value="B6264_03325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37789">
        <property type="protein sequence ID" value="OEV37789"/>
        <property type="gene ID" value="HS99_0024675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="234" mass="24181" checksum="2D99F6521ECA3227" modified="2017-01-18" version="1">MPLSVWLTEPLAGCCPTCENPTGAACAQRIPPGLARQITEAFSARGDLVFIPDAGNAAVLAAAVQAGRRVLALASSHQSAHLAYDTLHITAPTVASLAVLRRGTPGHPSGRADSQQGRARLAIAAPHDSATPVQLTALAETCTRALRPDGVLVICTRQTSGQETAGHVVAHARASGLVYLQHIAAVEATAGDAGLVPRAPVRTQHHPGCACHHPRPGSGRHALIHSDLLVFTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB66</accession>
    <name>A0A1E7NB66_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0023840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278258.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000768.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2112"/>
    <dbReference type="EnsemblBacteria" id="ARF79458">
        <property type="protein sequence ID" value="ARF79458"/>
        <property type="gene ID" value="B6264_11510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37908">
        <property type="protein sequence ID" value="OEV37908"/>
        <property type="gene ID" value="HS99_0023840"/>
    </dbReference>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11556" checksum="D27B05843BF1A574" modified="2017-01-18" version="1">MAGATTTVTDATFKSDVLESDKPVLVDFWATWCGPCRQVAPILEEIAAEQGDKLTVAKLDVDANQVTAAEYNVISIPTLILYKGGQPVKQITGARPKAALLRELDGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBF1</accession>
    <name>A0A1E7NBF1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0024300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000017">
        <property type="protein sequence ID" value="OEV37984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000011_gene2019"/>
    <dbReference type="EnsemblBacteria" id="OEV37984">
        <property type="protein sequence ID" value="OEV37984"/>
        <property type="gene ID" value="HS99_0024300"/>
    </dbReference>
    <dbReference type="OMA" id="PFLTHQL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="399" mass="40514" checksum="75D599FB2D0ED1FA" modified="2017-01-18" version="1">MGPPGRAAETTRGTAQTMTEAIMLVGGKGTRLRPLTTHTPKPMLPVAGVPFIAHQLARAAAAGVTRVVLATSYLAEVFEDHFQDGTPYGIELVYLTEREPLGTGGAIRNAASGLTCGPDEPVLVFNGDILSGLDIAALRDGHVAVGADVTLHLTRVEDPRAFGLVPTDANGRVLEFLEKPETPEQIVTDQINAGCYVFTRSVIDRIPAGREVSVERETFPELLATGALLRGVVDTSYWLDLGTPAAFVRGSADLVLGKVDSPAVPGPTGDALLLPGATVHPGAVLSGGTVVSADAVVEAGAIVEGSVILPGAVIGPDTLVKDSIVGAFATVGDRSALDGAVIGDGAIVESDNELPSGIRIACGTLLPVGAVRTTAGPGGCPAGTTAAAAVHGPSVTAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NBX0</accession>
    <name>A0A1E7NBX0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0023555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene465"/>
    <dbReference type="EnsemblBacteria" id="OEV38196">
        <property type="protein sequence ID" value="OEV38196"/>
        <property type="gene ID" value="HS99_0023555"/>
    </dbReference>
    <dbReference type="OMA" id="NNIRAWA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core2" evidence="2">
        <location>
            <begin position="52"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV38196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="290" mass="31425" checksum="2C1AD4A12CC3D719" modified="2017-01-18" version="1">MTEQSRDRFRTAARAEQPDPVLLCLLAAAEHDPALDPGDPGEPPGVDTLLAACEAAFDRHAAAVRAAVAERSPAGPEETAALLAAVLGGRERFHGRQSDYRRLESSLLPDVLRRRRGLPITLSLVWMEVGRRAGLTVHGIALPGHFIVAVGGPAGGEEYVLADPFHGGRLLDPADAERLVAAAGHDFAPALLTPAQPLDIVLRVLGNIRVWASDRPEHARTQLWATELALLLPRHPAQLRLERAELLVRMGDFLRGSAEMDSYAQILDAFDPDTAAKVRQEARAARHRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC16</accession>
    <name>A0A1E7NC16_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556909.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000883.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3319"/>
    <dbReference type="EnsemblBacteria" id="ARF80265">
        <property type="protein sequence ID" value="ARF80265"/>
        <property type="gene ID" value="B6264_16310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38225">
        <property type="protein sequence ID" value="OEV38225"/>
        <property type="gene ID" value="HS99_0021970"/>
    </dbReference>
    <dbReference type="OMA" id="QWITQWN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="121"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="567" mass="61023" checksum="E09B48428045CDB5" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NC52</accession>
    <name>A0A1E7NC52_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0022295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000015">
        <property type="protein sequence ID" value="OEV38271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284140.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000019_gene4210"/>
    <dbReference type="EnsemblBacteria" id="ARF80209">
        <property type="protein sequence ID" value="ARF80209"/>
        <property type="gene ID" value="B6264_15975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38271">
        <property type="protein sequence ID" value="OEV38271"/>
        <property type="gene ID" value="HS99_0022295"/>
    </dbReference>
    <dbReference type="OMA" id="DLKWWTG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="391" mass="42204" checksum="C6DE1587E9B62C0E" modified="2017-01-18" version="1">MSVPVIGVGERRARLGRRQLLAPSARAARVEDVADAVVGLHATDAATVYLSACARLAEPSAAEVDRALYGDVSLVKLLSMRRTIFAVTEGLAPYVSAGAARAIAAKERATLLKHLRDHAEGWDAARLAETEREVLAALAVRGEATTKELGEAVPQLRETMLMSAGKAYEAKQSVGSRLMRLLASDGHVRRCRPRGSWLSSSYPWALVPQWPDVPVREAKAEVVRRWLAAYGPGTVEDVKWWTGWTLGEVRTALADVGARGVALADGAAALVLPGDEGPVAAPEPWAALLPALDPAVMGWRGRDWYLRPEDVPALFDRAGNAGPTVWWCGEVVGGWAQRADGEVVWRLFRDVGVEAERAVAVEAGRLAAWLGEVRVTPRFRTPLERELVAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCA5</accession>
    <name>A0A1E7NCA5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0023225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000016">
        <property type="protein sequence ID" value="OEV38113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556802.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000055_gene5945"/>
    <dbReference type="EnsemblBacteria" id="ARF79679">
        <property type="protein sequence ID" value="ARF79679"/>
        <property type="gene ID" value="B6264_12880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38113">
        <property type="protein sequence ID" value="OEV38113"/>
        <property type="gene ID" value="HS99_0023225"/>
    </dbReference>
    <dbReference type="OMA" id="TAHPCEL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="392" mass="39163" checksum="8EAFDDE92CC683B4" modified="2017-01-18" version="1">MVRPLLVIPLLAAALGGIWLARGALQRWRDLRAAATYELAGERWPMLVRAGGAMVCGVCVTALTLLTALGAFGVLSRGRTGADRAQSAVDAAEAGAWPGSVPETAVRQQAAPPTAAASAAASGAATSAASAAPAGASAVASRFDSVGHPGGGELLQSAVLGPDGKPRNVRVWLPPQYAKESNARFPVVVMHAATPGKTADAEVPDVVEGVGAALQTGRIRPFILVAPEAPNGTAHPCELVAAAPAAVADDATLRVTIAASFRTLPPGPTSWGALGVEGGAPCAAAAGLARPDLYGAAAAVSGRYDAAALAQTGAEAPAGSSAKLLLAAAKGDAAGLDAARKLQTALKAGPGPAAKAEVRVSDNVQDYTADRERLRLVRQAAQFLAETLTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCL1</accession>
    <name>A0A1E7NCL1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554449.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000031_gene248"/>
    <dbReference type="EnsemblBacteria" id="ARF82225">
        <property type="protein sequence ID" value="ARF82225"/>
        <property type="gene ID" value="B6264_28095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38384">
        <property type="protein sequence ID" value="OEV38384"/>
        <property type="gene ID" value="HS99_0020960"/>
    </dbReference>
    <dbReference type="OMA" id="EWETVCE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="176" mass="18960" checksum="53FD6867EF97BABA" modified="2017-01-18" version="1">MRYADGPGAQCEVFVQAPVERVWALVTDIELPARLSPELQRVAWLDGAAGPAVGARFEGHNSRPSMRDWRTVSEVVELAEHRVFAWAVMDADGRFGDPVSEVAGALARWRFDLVPEGGSTRVRHSAVIGPGRSGVVLAIESRPEAEEKIVAFRLGELRTGMAATLEGIKSLAESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCV3</accession>
    <name>A0A1E7NCV3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligo-1,6-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554972.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000450.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3079"/>
    <dbReference type="EnsemblBacteria" id="ARF82114">
        <property type="protein sequence ID" value="ARF82114"/>
        <property type="gene ID" value="B6264_27455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38488">
        <property type="protein sequence ID" value="OEV38488"/>
        <property type="gene ID" value="HS99_0021590"/>
    </dbReference>
    <dbReference type="OMA" id="EGQTFWK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="531" mass="58508" checksum="73719FB397BC1C2B" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NCW3</accession>
    <name>A0A1E7NCW3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0021650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288381.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000340.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3091"/>
    <dbReference type="EnsemblBacteria" id="ARF82104">
        <property type="protein sequence ID" value="ARF82104"/>
        <property type="gene ID" value="B6264_27395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38498">
        <property type="protein sequence ID" value="OEV38498"/>
        <property type="gene ID" value="HS99_0021650"/>
    </dbReference>
    <dbReference type="OMA" id="EMARTHQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="152" mass="15802" checksum="DCFE3E1FF5A6A75F" modified="2017-01-18" version="1">MGSTSTTTVPTNAELMEALAAVGAAYFQDFAAAAARHGLSSSQAKALGAVQEPVPMRALAGRLGCDASNVTGIVDRLESLGLANREAAAGDRRVKIVVITAEGRDILSRIRSEMARTHQAFEAMTDEQRVALHSICGQVLPVLAGRTGGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND42</accession>
    <name>A0A1E7ND42_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HS99_0020325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551451.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000582.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene613"/>
    <dbReference type="EnsemblBacteria" id="ARF77639">
        <property type="protein sequence ID" value="ARF77639"/>
        <property type="gene ID" value="B6264_00740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38610">
        <property type="protein sequence ID" value="OEV38610"/>
        <property type="gene ID" value="HS99_0020325"/>
    </dbReference>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV38610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="465" mass="50209" checksum="6A31290E87320FB7" modified="2017-01-18" version="1">MPTSRAGAPTSAPQSRFDAEQRAIETLYADVVRRNKGEEEFHQAVHEVLETLAPVLAHRPELLDARLIERICEPERQLMFRVPWTDDSGDVHVNRGFRVEFSSALGPYKGGLRFHPSVNLGIIKFLGFEQIFKNALTGLAIGGGKGGSDFDPKGRSDAEIMRFCQSFMTELYRHLGEHTDVPAGDIGVGGREIGYLFGQYKRITNRYEAGVLTGKGLGWGGAQVRTEATGYGCVLFTAEMLRSRGEGLEGRRVVVSGSGNVAVYAIEKAQQFGATVLTCSDSSGYVVDEKGIDLELLKEVKEVRRGRVSDYAELRGGHVKFVEGPGVWSVPCEVALPCATQNELTEADALALVRNGVLAVAEGANMPTTPDAVRVLQKAGVAFGPGKAANAGGVATSALEMQQNASRDSWTFERTEERLAGIMKHIHDSCFTTAERYGHPGDYVVGANIAGFELVADAMLAQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND46</accession>
    <name>A0A1E7ND46_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0020485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551423.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene581"/>
    <dbReference type="EnsemblBacteria" id="ARF77668">
        <property type="protein sequence ID" value="ARF77668"/>
        <property type="gene ID" value="B6264_00900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38636">
        <property type="protein sequence ID" value="OEV38636"/>
        <property type="gene ID" value="HS99_0020485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="135" mass="14966" checksum="4F1DF712014AE50E" modified="2017-01-18" version="1">MGRLAVKTYQDWWQAQAEAFGRPDSDGSALAQYSSGRALSDTLVGLRQLHDAKVVMTGTPRNSALVKAIDLKADPQTAVIEDCVDLSDWHRVDAVTGAAKDPGGRLNRYVATASLRRFQAHWLIYEFTREVDRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7ND61</accession>
    <name>A0A1E7ND61_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387514.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000986.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000008_gene591"/>
    <dbReference type="EnsemblBacteria" id="OEV38629">
        <property type="protein sequence ID" value="OEV38629"/>
        <property type="gene ID" value="HS99_0020435"/>
    </dbReference>
    <dbReference type="OMA" id="WGLIVDG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="154" mass="16507" checksum="9055CD17790B90F3" modified="2017-01-18" version="1">MRVLSRLRRLGHRPAGRRSDRGAVALFVAICAAYLVLVVALVIDAGGRLRVAERTDAYAQEAARVGGQQLDRAAVLQGKGFKVQQDYVRQAAATYLNLYGLQVDDVTFSGDGKVVTVTVRADYRPVLLGALGQRKVTGKGSATLVHGVKNAETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDC2</accession>
    <name>A0A1E7NDC2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0021555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000014">
        <property type="protein sequence ID" value="OEV38483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554963.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000612.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000037_gene3072"/>
    <dbReference type="EnsemblBacteria" id="ARF82120">
        <property type="protein sequence ID" value="ARF82120"/>
        <property type="gene ID" value="B6264_27490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38483">
        <property type="protein sequence ID" value="OEV38483"/>
        <property type="gene ID" value="HS99_0021555"/>
    </dbReference>
    <dbReference type="OMA" id="YCETINI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="300" mass="33005" checksum="582048C6E762D299" modified="2017-01-18" version="1">MGFTLRQLEVFLTVAETLHFGRAAERLHISQPTVSQEVARLERTVGVELFDRSRRSVALTGAGEVMAAESARLLEQAGALLTRVRLHEESRLGTARIVASPSVVNRLLPAVVSRAEQELPALDTAELAVDTGQVSATLAGELADIGLGRFLEEVSGYRLERIADEPVRVALGRDHPLAGRVSLGLTELRDLPLLLWPREQHPRYYDHVLGLCAERGVDPPVLVSPPRIVGSRLYLLARNRAFSLVPGSLTGHLTEDVATVPLEGRATLPLEMQWRTDDRRPALATLRNVIRQEAAKLEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDH0</accession>
    <name>A0A1E7NDH0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286319.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000495.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7321"/>
    <dbReference type="EnsemblBacteria" id="ARF81148">
        <property type="protein sequence ID" value="ARF81148"/>
        <property type="gene ID" value="B6264_21570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38740">
        <property type="protein sequence ID" value="OEV38740"/>
        <property type="gene ID" value="HS99_0018840"/>
    </dbReference>
    <dbReference type="OMA" id="SRTCGNR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="189" mass="21055" checksum="6A1260D48553DB95" modified="2017-01-18" version="1">MLITHDTECALSILVDLLNTAPEVCGDERLPDIAALDAFVRRQEISEIDSLTEDDLRQVQELRTRLRDVFGTESTEEAADLVNAIVAAAGTTPRLVNHDHHDWHIHYFAPHAALGPHLAAELGMALTFILMAGERERLRRCGAPDCARVFVDLSRNRSRRYCDSRTCGNRLHVAAYRARQRSAEAVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDJ6</accession>
    <name>A0A1E7NDJ6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0020540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000013">
        <property type="protein sequence ID" value="OEV38724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737805.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1761"/>
    <dbReference type="EnsemblBacteria" id="OEV38724">
        <property type="protein sequence ID" value="OEV38724"/>
        <property type="gene ID" value="HS99_0020540"/>
    </dbReference>
    <dbReference type="OMA" id="SHTEWLV"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV38724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="406" mass="43010" checksum="B43B66F8FA3508FD" modified="2017-01-18" version="1">MQDRSGEELPDAERRIAARLLLAHPLVTASGPHADGFPLIRRHRDWLTERFDTLLGYRLVIGPWHARLFKAGLGPGAARRLEHPATGAPFTPAGYARLALALALLVDAPEQLPYGRLVQAMRAAAPDLAAEGAPTGTAALDTSLGAALDASLDMALAALADWQVLGELPADPGDTAFVLTVDRELARAVPAGPPALADDAADLIRRAAEAEPGTAVRRLLAETPAVLTTDLPEDQREWLREHRLSGPAALAEFLGLEAELRAEGVALLDPAAELTDLALPGAGTLAQAALLLVERLVEEVRPLPGEDPGGDVAIPDALIDGVLGDIADDHDLPARYLADRTALRRDALDLLHRLGLITPTPRATWLLRPPAARYAPAPDLRPTPGTGRHSRPTTPTPPPPREGPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDR8</accession>
    <name>A0A1E7NDR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556351.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000050_gene5138"/>
    <dbReference type="EnsemblBacteria" id="ARF81259">
        <property type="protein sequence ID" value="ARF81259"/>
        <property type="gene ID" value="B6264_22260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38856">
        <property type="protein sequence ID" value="OEV38856"/>
        <property type="gene ID" value="HS99_0019525"/>
    </dbReference>
    <dbReference type="OMA" id="RAQYPAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="30088" checksum="324AC917CCD1C5E9" modified="2017-01-18" version="1">MAEQDDGVGLLRAFGRQLKLLRERAGLSRAQLGARLGYGEDLIASVELGRRIPRPELIDRADHELNAAGVLIAMKDEVARARYPAFFRDAAKLEAEAVELQSYDTHVVNGLLQTEEYMRALLAMRRPLLEESVIEQRVAARLARQELFAARISPLMSFVMEESVLLRRLGGAAVMRGQLEQILLVGQRRNVEAQVMPLDREDNAGIDGGFTLFTRKGGEQVGYMETQGHSTLVTDREEVRALASRHGIIRAQALTPRESLAYVEKLLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDT5</accession>
    <name>A0A1E7NDT5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555428.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6504"/>
    <dbReference type="EnsemblBacteria" id="ARF81278">
        <property type="protein sequence ID" value="ARF81278"/>
        <property type="gene ID" value="B6264_22360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38871">
        <property type="protein sequence ID" value="OEV38871"/>
        <property type="gene ID" value="HS99_0019625"/>
    </dbReference>
    <dbReference type="OMA" id="SLSHACW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="453" mass="47037" checksum="CCAA5A9B63AA2F27" modified="2017-01-18" version="1">MLTVLRNRTYRHLFTAQVVALIGTGLATVALSLLAYSIAGNNASAVLGTALAIKMIAYVTVAPVAGVLAGRVPPRTLMVGMDLTRAAVALALPFVDQVWQIYVLIFLLQAASAAFTPTFQATIPDVLPAERDYTQALSMSRMAYDFESLFSPALAALLLSVVSYNWLFAGTTAGFLASATLVVSAVLPGPKPVERGGGLYRKAAFGTRLFRATPRLRALLALDLAVAATGAIVFVDTVNVVRDHFHRPAGAVSLALGAYGVGSMLAAVLLPRLLARVSDRSVMLPAAFALPCVLAAAAAITAAPAGTGTWFALLASWALVGAAGSAVLTPGGRVIRRSAADPDLPAAFAAQFSLSHGCWLLTYPLAGWLAAGAGLPATAVVLGALALVAAVTATTLWPARDPDTLSHLHTDLPVGHPHLADAHPAGGGAWQHGHHYVIDQHHPTWPRHRPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDV1</accession>
    <name>A0A1E7NDV1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">o-succinylbenzoate synthase</fullName>
            <shortName evidence="3">OSB synthase</shortName>
            <shortName evidence="3">OSBS</shortName>
            <ecNumber evidence="2 3">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menC</name>
        <name evidence="4" type="ORF">HS99_0019605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="2 3"/>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555421.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6500"/>
    <dbReference type="EnsemblBacteria" id="ARF81274">
        <property type="protein sequence ID" value="ARF81274"/>
        <property type="gene ID" value="B6264_22340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38869">
        <property type="protein sequence ID" value="OEV38869"/>
        <property type="gene ID" value="HS99_0019605"/>
    </dbReference>
    <dbReference type="OMA" id="GRQDEWF"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03317">
        <property type="entry name" value="NAAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01933">
        <property type="entry name" value="MenC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010197">
        <property type="entry name" value="OSB_synthase_MenC_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48073:SF5">
        <property type="entry name" value="PTHR48073:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01928">
        <property type="entry name" value="menC_lowGC/arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV38869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="369" mass="39566" checksum="943A1048DD0CE00F" modified="2017-01-18" version="1">MKLQQAELREVALPLVAPFRTALGTQEHRNSLLVKVTTADGAVGWGECVADDDPTYSAEYLAGAREVVRQFLLPRLSRAPELTAALVPELLRPVRGNPMAKTAIEMAVLDAELRTAGISLAQYFGATRTELAVGVSVGITDTVDELISAVDGYLRAGYARIKLKIEPGWDIEPLRAIRETFGPDIALQVDANTAYGPADQPHLRRLDAYGLTLIEQPFAPDDLLSHTRLAARMDTPICLDESITSARDAATAIRQEACSIVNIKPGRVGGYLEARRIHDLCLANGVPVWCGGMLETGLGRAANLALAALPGFTLPGDISASARYYTRDITAPFVLHDGRLTVPTRPGIGVLPDPDALQAATTSTELLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NDX5</accession>
    <name>A0A1E7NDX5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6505"/>
    <dbReference type="EnsemblBacteria" id="ARF81279">
        <property type="protein sequence ID" value="ARF81279"/>
        <property type="gene ID" value="B6264_22365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38872">
        <property type="protein sequence ID" value="OEV38872"/>
        <property type="gene ID" value="HS99_0019630"/>
    </dbReference>
    <dbReference type="OMA" id="WTSEMAG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="129" mass="13889" checksum="A0A870AD3B15B687" modified="2017-01-18" version="1">MSAHAHGPYDDAMSSGTDPADAHRSQQRAEARLDVAASVLALLADRTRLALLERLGRGEADVTTLTGATGAARPSVSQHLAKLRLAGLVTTRKDGRRVVYSLRHGHLRRLVDEALNVADHQIAHLPPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE27</accession>
    <name>A0A1E7NE27_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558248.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000442.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83170">
        <property type="protein sequence ID" value="ARF83170"/>
        <property type="gene ID" value="B6264_29940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38947">
        <property type="protein sequence ID" value="OEV38947"/>
        <property type="gene ID" value="HS99_0017685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="85" mass="8639" checksum="55CEE1309436C9AE" modified="2017-01-18" version="1">MTSTQPLPRGISALIPNAHAQATPGELAAAQLLHLRSATVPVPVLAAAAALIAPQLEDPDPATREAADAVRTHLLAAIEDAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE63</accession>
    <name>A0A1E7NE63_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0019115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000012">
        <property type="protein sequence ID" value="OEV38783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553687.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000589.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7375"/>
    <dbReference type="EnsemblBacteria" id="ARF81190">
        <property type="protein sequence ID" value="ARF81190"/>
        <property type="gene ID" value="B6264_21850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38783">
        <property type="protein sequence ID" value="OEV38783"/>
        <property type="gene ID" value="HS99_0019115"/>
    </dbReference>
    <dbReference type="OMA" id="GMLIQIE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="190" mass="20261" checksum="51AA450CF718FA3E" modified="2017-01-18" version="1">MPDPDLVSRALARNVKRLRTERGHTLDALAARSGVSRGMIVQIEQGRTNPSVATVVRIGDALGVSIATLLDYEEGPDVRVVPGDQAVPLWTGPKGGTGTLLHGIEAPGPLELWDWRMAPGEEYSAEPHPAGTVEILRVVEGELALVHGGRVHAVPAGSTVSFDASHAHVYRNAGERELRLTMVVSVPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE77</accession>
    <name>A0A1E7NE77_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557368.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4362"/>
    <dbReference type="EnsemblBacteria" id="ARF83225">
        <property type="protein sequence ID" value="ARF83225"/>
        <property type="gene ID" value="B6264_30255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38997">
        <property type="protein sequence ID" value="OEV38997"/>
        <property type="gene ID" value="HS99_0017985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="151" mass="17429" checksum="C5C5364067951C9F" modified="2017-01-18" version="1">MKQRSRISTDARRAYYCADSTRRWIARCIGPRRVGGIYRGPYAGDAPYEVLAIDPGPREGWPTWQITVRTVGEDRIRRHCTAWDHERDVVIKQPEDENFAQAWAAWQLTHDPDPWTPREADSPDWQHVLDEIAHPVSTAAFQKLAHTARIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE88</accession>
    <name>A0A1E7NE88_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557540.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF83257">
        <property type="protein sequence ID" value="ARF83257"/>
        <property type="gene ID" value="B6264_30425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39026">
        <property type="protein sequence ID" value="OEV39026"/>
        <property type="gene ID" value="HS99_0018155"/>
    </dbReference>
    <dbReference type="OMA" id="YLALWPD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="43400" checksum="5370C1F9618024AC" modified="2017-01-18" version="1">MKAADRLGTGGAFGAISRTPRSERGRAKAQAEGSIPDYEIQRIPLARVALCPMNPRRYYGTEEQREALGQSLAKKQTTACVAVTRAAYLALWPSHVRLISEEAEFVLLNGERRCRSAAQVGLEVLDFVVRDDLATSPADFMDYLMAENEDREDFNIIERAMGLEQLLKACDGNAAEVARRRGRDRSWVGNQILLLTLPSAIQDRLASGEMAERYGRRLARAYKDDKSLTTDDLLALEERLKEEERAKRIASRDALKMLSADNIPAALAQPAVAEPPQASVLSADNTGPASASTGREAPAAAAASERKVLSADNTRQPVALPDGQTDALVVPAKQNPAGSPVDFQQAPLPRQTPAPDPVPSLTAYQLVRALGETVEEQAATLRAGLDTDGFRALLEALHSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NE98</accession>
    <name>A0A1E7NE98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0017955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV38992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557359.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000124.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000065_gene4356"/>
    <dbReference type="EnsemblBacteria" id="ARF83221">
        <property type="protein sequence ID" value="ARF83221"/>
        <property type="gene ID" value="B6264_30225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV38992">
        <property type="protein sequence ID" value="OEV38992"/>
        <property type="gene ID" value="HS99_0017955"/>
    </dbReference>
    <dbReference type="OMA" id="DRPLGTW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV38992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="303" mass="31044" checksum="929934C168EA1A1E" modified="2017-01-18" version="1">MSTPFGDPDLVIVGGGPAGCAAALMAASLGLRSALIESNNIGGRLHVIGALSNVPGDWADGPSLAQALARDIRRIQESGHCTVITGRATAVSADSRSASVTLADGSTVTGNAVIAATGVASITPAEAGWISAPADLDPAPLWRARPADLKGRACVLGGDRPLGTWLRAHPDVQRQLLVVHPATDDYKTAEVQQDSRAQLRRARHVTLNPAPCGGYIVDVEATDGSTTAYACDTLLTNIGNRPAALPGLTADEDGYCPSDSQGPLIATAGDLRSARFQRIVTAQGSGAQAVLSCYYSTAVRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NEE5</accession>
    <name>A0A1E7NEE5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0018270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000002">
        <property type="protein sequence ID" value="OEV39044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557509.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000068_gene1018"/>
    <dbReference type="EnsemblBacteria" id="ARF83275">
        <property type="protein sequence ID" value="ARF83275"/>
        <property type="gene ID" value="B6264_30535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39044">
        <property type="protein sequence ID" value="OEV39044"/>
        <property type="gene ID" value="HS99_0018270"/>
    </dbReference>
    <dbReference type="OMA" id="NGMIGRT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="134" mass="15042" checksum="924BFC7F48298241" modified="2017-01-18" version="1">MATAENVTEPMASWDPYTRGCPSRDLLDQIGSKWAVLVLGELGKHGACRFTRLRQRLAGVSEKMLTQTLRTLERDGLVRRTVYPEVPPHVEYDLTPLGQTLRGPLRVLTQWSVEHVGEVLAARQEYDVRAEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF28</accession>
    <name>A0A1E7NF28_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0000960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030284885.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000636.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000002_gene3658"/>
    <dbReference type="EnsemblBacteria" id="OEV39316">
        <property type="protein sequence ID" value="OEV39316"/>
        <property type="gene ID" value="HS99_0000960"/>
    </dbReference>
    <dbReference type="OMA" id="VPIDACY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045991">
        <property type="entry name" value="DUF5947"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19372">
        <property type="entry name" value="DUF5947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22373" checksum="4294CEF9ED9B5FEF" modified="2017-01-18" version="1">MTAGALHRLIREARAEPAGPAEPPERCELCGEQVPEDHRHLLDTEAQTVLCVCRPCTLLFGRETEAEEGRYRLVPGRRVRLEPVPTDRLGVPVGLAFFVPQPDGSVLAHYPSPAGAARWEVDPQAWRTACELRPELRTMRAGVEALLVNTVRGQSQHWIVPLADCLRMVAVVRQEWRGLSGGSRIWPALEQFFGELTEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NF93</accession>
    <name>A0A1E7NF93_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0001315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556024.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000446.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1552"/>
    <dbReference type="EnsemblBacteria" id="OEV39376">
        <property type="protein sequence ID" value="OEV39376"/>
        <property type="gene ID" value="HS99_0001315"/>
    </dbReference>
    <dbReference type="OMA" id="PSHFGWS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="145" mass="15217" checksum="450CEA17A85A9714" modified="2017-01-18" version="1">MNANDSLPRVVVGVDGSQPSRAALRWAVRHAAMLGGVVDAVGAWEPPSHFGWSAPVVDATFDQELAERKFADELGEVLGTDCPVQVRRTMVMGDASDVLLDAAKGAELLVVGSHGRGGFTRALLGSVSTRCAQHATCPVVIVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFA2</accession>
    <name>A0A1E7NFA2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288888.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000596.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV39354">
        <property type="protein sequence ID" value="OEV39354"/>
        <property type="gene ID" value="HS99_0001175"/>
    </dbReference>
    <dbReference type="OMA" id="TEAFALC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="165" mass="17097" checksum="9AF331129985D112" modified="2017-01-18" version="1">MVPWLFLVTLTAYGVVAGLTARTVFARSRAGFVASRGGGPTEWVQERFEQQERAQAEAVALMSGLCWVVAIPALVLRRVVAGLVLCRPAVSQTPAMPAPTVADRIEELERALGLGAPSPIPLLGDSPEPRGAGDGGTKAAHAPAEDATAVHAEAVHAVTEGARAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NFC3</accession>
    <name>A0A1E7NFC3_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0001395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030288803.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000150.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000047_gene1568"/>
    <dbReference type="EnsemblBacteria" id="OEV39387">
        <property type="protein sequence ID" value="OEV39387"/>
        <property type="gene ID" value="HS99_0001395"/>
    </dbReference>
    <dbReference type="OMA" id="DRFGYWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="322" mass="34499" checksum="0593A76BDE77BCBE" modified="2017-01-18" version="1">MRILIMGGTRFVGYHFARAALAAGHDVTVLHRGRSGAHLLPDATHLIADRDADLSVLRGLAWDATVDVSAYFPRQIRQLAAALDPGAAGRYLLVSSMAVYDTPTAPGFTERSPLLPADGPEAEAITAATYGVLKVQCEREARESFGPDVLLVRPTYVIGPEDYTHRFDHWVQRLARGGEVLAPGRPETPIQVIDARDLADWMLGLLDQGASGPFHAATPPPFSMGDLLDAVASAVAPPGTTLTWVDEDFLGAAGVQDQALPLWSTNPLIRATGTADPSAALATGLKVRPVADSARDIRPFDPLPQTLTPDQEAELLTAWHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG35</accession>
    <name>A0A1E7NG35_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0002890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550343.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2772"/>
    <dbReference type="EnsemblBacteria" id="OEV39634">
        <property type="protein sequence ID" value="OEV39634"/>
        <property type="gene ID" value="HS99_0002890"/>
    </dbReference>
    <dbReference type="OMA" id="SARWIDD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199101" evidence="1">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="41"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="364" mass="38548" checksum="DBDEBE051F153720" modified="2017-01-18" version="1">MRKLSAGLVAVGLTLSLAACGQSANGAGDGAAKGDAKGGLIGIAMPTKSSARWIDDGNNMVKDFQAKGYKTDLQYGDNVVENQVSQVENMITKGAKLLVIAAIDGSSLTNVLQKAADAHVPVISYDRLIKGTQNVDYYATFDNYKVGVLQGGYIVDKLGLKDGKGPFNIELFAGSPDDNNATFFFNGAMSVLKPYIDQKKLVVQSGQTDFNQVATLRWDGGVAQSRMDNLLSKAYTTAHVDAVLSPYDGISIGILSSLKGVGYGTAKSLPIVTGQDAELASVKSIIAGEQTETVYKDTRQLSKVAVQMGDALLTGGKPEVNDTTQYNNGAKVVPAELLQPVSVDKDNYQKILVDSGQYTADQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NG90</accession>
    <name>A0A1E7NG90_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550436.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2850"/>
    <dbReference type="EnsemblBacteria" id="OEV39697">
        <property type="protein sequence ID" value="OEV39697"/>
        <property type="gene ID" value="HS99_0003280"/>
    </dbReference>
    <dbReference type="OMA" id="SAWHART"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV39697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="355" mass="37425" checksum="999F02711AE5F383" modified="2017-01-18" version="1">MEPQGNEWDARVAGVRRFAEAGNLDGLVRSLYGLNVDLDGDWAGDGGGQVIELLGRMPIPDRVQLLCRMTEGLEETAVHAPRECPGLARLVVRLSEGLSCEQLAAWREPLLDLAAGMMTLWEGWRLGCLAEVELAAGRCLPDAVVATVRRTALAAETPGELLDVAAGIAEPPLNPGEPWADRALADLAVTGPAWHPLIGHALSLSGSRPGVGWQRAGRQLLAELGPERVRSAVCGWLALAGEPRSLPVASYYGSGTAGFEMDPFNVRALQGVAALLALAPAHPDSAAALGRLVEAALLRIPGVGPRSHKTASAAVHALVQLGDEDAYDELERLAGTVKYRPTVNLVTKALAARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGA4</accession>
    <name>A0A1E7NGA4_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_42M domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2799"/>
    <dbReference type="EnsemblBacteria" id="OEV39655">
        <property type="protein sequence ID" value="OEV39655"/>
        <property type="gene ID" value="HS99_0003025"/>
    </dbReference>
    <dbReference type="OMA" id="GKFHTSW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028212">
        <property type="entry name" value="GHL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14871">
        <property type="entry name" value="GHL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42M" evidence="1">
        <location>
            <begin position="350"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="646" mass="70082" checksum="F928C2F1B1FAD135" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGE5</accession>
    <name>A0A1E7NGE5_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH luxR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0003600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367072.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2917"/>
    <dbReference type="EnsemblBacteria" id="OEV39747">
        <property type="protein sequence ID" value="OEV39747"/>
        <property type="gene ID" value="HS99_0003600"/>
    </dbReference>
    <dbReference type="OMA" id="FQAGVHA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV39747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="268" mass="29324" checksum="7F259D7EB14671C7" modified="2017-01-18" version="1">MGRILDSARRAIGELACTVEALDRELAEVNIAAIPAHLDRLGGHGVEVFRGEAAVRQLLEDATMTVRGQVLSMNPGAPPAAALLVAGRRRDEEVLGRRVSIRTIHSESMLRVPRGRAHLKALRRAGGQIRISATLPYRLIVLDADLAFVPPPNSGDGAEPALVVVRNPDLVSLFVQTFEFCWQEARPAEVAPPSRQGPTARQYQVLRLMQLGYKDEAIAREIGVSSRTMRRIVRELFEQLDATGRFSAGMAAQARGWLVPPRSREGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NGN2</accession>
    <name>A0A1E7NGN2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0003080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2810"/>
    <dbReference type="EnsemblBacteria" id="OEV39860">
        <property type="protein sequence ID" value="OEV39860"/>
        <property type="gene ID" value="HS99_0003080"/>
    </dbReference>
    <dbReference type="OMA" id="ACPPWML"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009199134" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV39860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="435" mass="45776" checksum="A84C56CD651215C4" modified="2017-01-18" version="1">MRKVPKPLLSAATAALGALLVAGCSSAGSGSGGAAASDSKITLTVGDYGTFGYKQAGLFDAYMREHPGITIVEHTVEQETDYYPALQTHLASGSGLDDIQAVEVGRIAQVVKKQANKFVDLGKADGVDKGAFLPWKSQQASTTDGRTIGLGTDIGPMAICYRKDLFQQAGLPTDREEVAKLWQGDWAKFVETGKQYQAKAPAGTFFTDSAGGLFNAVVSSSTTQYDNGSGQLDYKNSPSVKNAWNLATGAVQAGISAGLKQFDTPWYQAFANSKFATVACPSWMTAIVADKSGSANKGKWDIATAPAAGNWGGSFLTVPKAGKHQKEAEALAAWLTAPAQQAKVFTTVGNLPSNTQALGRPEVQNAHLDFFGDTPTGRIYAATAQSIQPTVIGEWDGLVKDTLTNGALLSIEQHQSDPAKAWGNAVKEIDDKVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NH17</accession>
    <name>A0A1E7NH17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HS99_0003630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000001">
        <property type="protein sequence ID" value="OEV39753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279545.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000263.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000003_gene2923"/>
    <dbReference type="EnsemblBacteria" id="OEV39753">
        <property type="protein sequence ID" value="OEV39753"/>
        <property type="gene ID" value="HS99_0003630"/>
    </dbReference>
    <dbReference type="OMA" id="ALKACEY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OEV39753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26468" checksum="3A1C4AFC617B9862" modified="2017-01-18" version="1">MTVPVPVPVAVCGLTGRMAGVVRQAVLDAPDLALSARLSLRPPAPDPAEANPPAPVVHRLADLPDAHPVVVDFTAEEATAELLDQARTVPCALVIGTSGLGERHQRLLAEVGRSRAVVVAANYSLALLAVTRFVEDLAAQSDDSWNAGVGDLHFAGKRDRPSGTARHLAAAWQGARGPGAPAPDITSFRLGDALSEHRVVAAGSGEHVEVLHRMADRRAFLPGVLRAIRYAATAGPGVRGLADVVREPVPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MV65</accession>
    <name>A0A1E7MV65_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-requiring protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0016575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030553783.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000616.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6905"/>
    <dbReference type="EnsemblBacteria" id="OEV32319">
        <property type="protein sequence ID" value="OEV32319"/>
        <property type="gene ID" value="HS99_0016575"/>
    </dbReference>
    <dbReference type="OMA" id="AANWYAR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="4">
        <location>
            <begin position="199"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="5">
        <location>
            <begin position="388"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="601" mass="65789" checksum="0936DEE361C8E5E1" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVG2</accession>
    <name>A0A1E7MVG2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0017185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386318.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000312.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000103_gene7519"/>
    <dbReference type="EnsemblBacteria" id="OEV32422">
        <property type="protein sequence ID" value="OEV32422"/>
        <property type="gene ID" value="HS99_0017185"/>
    </dbReference>
    <dbReference type="OMA" id="YACHRRI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="363" mass="37763" checksum="EA4A9E1338AE4668" modified="2017-01-18" version="1">MAADDEPLSPRAPGNGAVAVGVLVATALVLLAQAASGTSSRLVLLLVFLPALLAGLGTVAQTVAVSVWVSAVVAVYSALYPPADLPARLGTLLGVVAAEAAVIALCARRVRRERQLFRMRQSAVALQRQLLRPLPVRTAELDLFGLYRPVEEDTLIGGDLYDVAETPHGTRVLVGDVQGKGLRAIGTGFAVLSAFREAAFREAELTAVADALEAAVERHNAYAVQSGEPERFVTATVLCVRRGGDVRAVNCGHLAPCLLHPDGRVEAVGLPAGVPLGLAALTGEPRTMERFALPEGGVLVLLTDGITEAQDASGAFYPAEQGLAELAGTPAAELPGALDGCARRWSGGRSRDDVTVLVLRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MVS3</accession>
    <name>A0A1E7MVS3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0016830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000097">
        <property type="protein sequence ID" value="OEV32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289606.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000695.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000025_gene6955"/>
    <dbReference type="EnsemblBacteria" id="OEV32363">
        <property type="protein sequence ID" value="OEV32363"/>
        <property type="gene ID" value="HS99_0016830"/>
    </dbReference>
    <dbReference type="OMA" id="IRVEPHW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="122" mass="13403" checksum="92EF737B06F4F624" modified="2017-01-18" version="1">MAGLLIDGDDLVVRLAWWERIVARRREVRVPLDTVTEVDVQPDRWRALRGVRIGGLAVPGALCLGVWRHKDGRDFVALRGHRAVLCVGLRPPAPFAGLAVETDDPLRTAAELRTVRGRAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWI7</accession>
    <name>A0A1E7MWI7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385742.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000110.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3821"/>
    <dbReference type="EnsemblBacteria" id="ARF78358">
        <property type="protein sequence ID" value="ARF78358"/>
        <property type="gene ID" value="B6264_04975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32603">
        <property type="protein sequence ID" value="OEV32603"/>
        <property type="gene ID" value="HS99_0015105"/>
    </dbReference>
    <dbReference type="OMA" id="HLRDCYR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="340" mass="37683" checksum="0D472305962B6A96" modified="2017-01-18" version="1">MTTAITLDAEPRLGGLVCGLSSPGRPALTELGAQHGPSIRERVVGHGAALLSGYEWTDWNDLDAFVKQVVGSPLDYTERSSPRTELHPGVFTATDHPPTEEIFLHTEQSYNLTVPRYLFFFCRQGAPEGGANRLADCRAVHDALPREVVERFDREGYLLVRNFLPGLGLTWQQAFGTEDPERVRRYCADNGIEVEWLSEDHVQTRQVRWAVATHPETGAKSWFNHMTFFHSSSLNKDLAELLLEEYGPRGIPTNTFHADGTEIAPDVVEALHAGYRDHQVDVTCRTGDVLIVDNLSVAHGRAPFVPPRELFVSMADALSWERLRPVERTALPGGAVGHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWR8</accession>
    <name>A0A1E7MWR8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0039620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000079">
        <property type="protein sequence ID" value="OEV32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287367.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000122.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene447"/>
    <dbReference type="EnsemblBacteria" id="ARF78862">
        <property type="protein sequence ID" value="ARF78862"/>
        <property type="gene ID" value="B6264_07980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32885">
        <property type="protein sequence ID" value="OEV32885"/>
        <property type="gene ID" value="HS99_0039620"/>
    </dbReference>
    <dbReference type="OMA" id="LMFAGQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="308" mass="33585" checksum="4648738DCA2556F5" modified="2017-01-18" version="1">MGSYVLRRVLQMIPVFFGTTLLIFVMVYTLPGDPVTALFGEKAADPAVVASIKHKYFLDQPLWKQYLHYMGNLFQGDFGTSFTGRPVSDIMAGAFPVTIRLALLAFVFEMILGLALGMLSGLRRGSVQDTLVLVLTLMVISIPVFVLAYIAQTVFATNLGWVTPTVQDSYDLSQLVLPAVVLGSLSLAYVARLTRTSIGENLRADYMRTAVAKGLPRRTIVLRHLLRNSLIPVITFLGTDLGALMGGAIVTEGIFNVQGIGNVLYRAINTKEGPTVVGIVTVLVIIYLVASLLVDLLYAVLDPRIRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW8</accession>
    <name>A0A1E7MWW8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0015860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000087">
        <property type="protein sequence ID" value="OEV32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366530.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000434.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000072_gene7836"/>
    <dbReference type="EnsemblBacteria" id="ARF78227">
        <property type="protein sequence ID" value="ARF78227"/>
        <property type="gene ID" value="B6264_04225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32733">
        <property type="protein sequence ID" value="OEV32733"/>
        <property type="gene ID" value="HS99_0015860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="10965" checksum="0E7F369218D578AB" modified="2017-01-18" version="1">MADFTVSPEFLAKLAKDLKGCGDELDQGLKALKEASRDGLGFDFLEDAGKHFQEKWEYGLKKVRECVKVLDEGLEKARQSYAGTEQDIAKALTPARGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MWW9</accession>
    <name>A0A1E7MWW9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chaplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555494.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000173.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000042_gene6556"/>
    <dbReference type="EnsemblBacteria" id="ARF81324">
        <property type="protein sequence ID" value="ARF81324"/>
        <property type="gene ID" value="B6264_22615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV32914">
        <property type="protein sequence ID" value="OEV32914"/>
        <property type="gene ID" value="HS99_0013600"/>
    </dbReference>
    <dbReference type="OMA" id="NLEANIC"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005528">
        <property type="entry name" value="ChpA-H"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03777">
        <property type="entry name" value="ChpA-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51884">
        <property type="entry name" value="CHAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="79" mass="7648" checksum="4A774C6A6571F9B4" modified="2017-01-18" version="1">MRIRTTLAAAALAAVAVLAGAGTAAAGDATANGVAANSPGVLSGNQIQFPINFEANFCGNTINLPGFLNSTAGNVCING</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MX93</accession>
    <name>A0A1E7MX93_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5666"/>
    <dbReference type="EnsemblBacteria" id="OEV33034">
        <property type="protein sequence ID" value="OEV33034"/>
        <property type="gene ID" value="HS99_0014270"/>
    </dbReference>
    <dbReference type="OMA" id="WPDAYIF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="215" mass="23457" checksum="EB420FA21CB4D8B9" modified="2017-01-18" version="1">MSWLSGEAFTVLGEHVKWADMIGNLLGFGGLALGWRRSVWSWPVQLLSGVVLITAYLGGHVPGLIGKQLIVIVTAAWGWAQWRRGRRDTGTIAVRFASWPERAALVAGTAVGTVGLALLFTAYPKLSWSPWSDAYIFVGTLAAMVAQARGWLEFWFAWIAVDAVGVPFAFNSGYTFSGLTYSVYFVLVLLGLRSWWLSTREPRATSSNVPQGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ0</accession>
    <name>A0A1E7MXJ0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0014300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046385585.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000014_gene5660"/>
    <dbReference type="EnsemblBacteria" id="ARF83015">
        <property type="protein sequence ID" value="ARF83015"/>
        <property type="gene ID" value="B6264_23330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33157">
        <property type="protein sequence ID" value="OEV33157"/>
        <property type="gene ID" value="HS99_0014300"/>
    </dbReference>
    <dbReference type="OMA" id="ILTPRTQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="446" mass="47212" checksum="15E46A507AB3159B" modified="2017-01-18" version="1">MTAWLLLLAAVLLILANGLFVAAEFAFVTADRGAVERSAEAGDAKSGRVARALRHLSFELSGAQLGITVTSLVVGMLAEPALSTLLQPVMSGIGVPDPAARGVAVVVGMVLATVVQMVIGELVPKNWAISRPLQVARAVAAPHMAFSFVCRPLISFLNGAADRTVRAFGIEPQEELEHARTPAELVSLARHSAKAGAIDEESATLFVRTLGLGDLTAESVMTPRIDVSALQRDATASDVINLTRATGLSRFPVYADTVDEVTGIVTLKDALAVPAARRGQVRVADLASPPLLVPETLPAERLLDQLRRLQPMAIVVDEYGGTAGVVTVEDIVEEIVGEVQDEHDPADQPDLLPLPSVDGLPVWQADGRARLDQLEAIGLNAPDGPYETLAGLVADLLGKLPEVAEQAELPGWRLTVTGVDRHRTSQVRVERTSAPGLFGEQAEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXJ7</accession>
    <name>A0A1E7MXJ7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0014880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000076">
        <property type="protein sequence ID" value="OEV33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046386844.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000005_gene2679"/>
    <dbReference type="EnsemblBacteria" id="OEV33131">
        <property type="protein sequence ID" value="OEV33131"/>
        <property type="gene ID" value="HS99_0014880"/>
    </dbReference>
    <dbReference type="OMA" id="IVQACEF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="354" mass="37645" checksum="8BEDC7715EBD3FB7" modified="2017-01-18" version="1">MGRPTIADIARRAGVSKGAVSFALNGRPGVSEETRERILRVAEEMNWRPHHAARALGGARSDAVGLVIARPARTIGVEPFFSHLLSGLQAVLSASSVALHLMVVEDTAAEIEVYRRWASEHRVDGFVVVDLQVRDPRLPVLDELGLPAVVLGGPGKGGNQLRIWADDREAMLSIVDYLAAIGHRRIAHLAGLPHFQHTQRRIRALRDASRRLGLEAVSVPTDFSDAEGAAATRTLLSRAGRPTAIVYDSDVMAVAGLGVAGEMGVAVPGELSIVSFDDSVLARIVHPPLTALSRDTFALGEQVARSLLEAVEGAGPGRDLQMPTPRLTVRESTSPPSPVGVVAARFVDTGSEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MXX6</accession>
    <name>A0A1E7MXX6_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R2K_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000067">
        <property type="protein sequence ID" value="OEV33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556870.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000172.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000057_gene3278"/>
    <dbReference type="EnsemblBacteria" id="OEV33298">
        <property type="protein sequence ID" value="OEV33298"/>
        <property type="gene ID" value="HS99_0038775"/>
    </dbReference>
    <dbReference type="OMA" id="AHELPGW"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025643">
        <property type="entry name" value="R2K_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14243">
        <property type="entry name" value="R2K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R2K_3" evidence="1">
        <location>
            <begin position="140"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="331" mass="34961" checksum="29CBD61A27F48322" modified="2017-01-18" version="1">MPVPSMLFPADPLNPRRPDPHFAWEARLVRELGAEHLLVDHDALLAGRAEEAVRRVPLGSGPLWYRGWMLPSARYAEFAAALTARGGKLLTSPPGYAAAHELPGWYGVFEGATPPSVWIPTAGAVPPTPEELAEAVARLGGSGPAIVKDYVKSRKHEWHEACYVPELADLAAVGRVVGRFVELQGEFLAGGVVVRRYEEFERADGPDGDGLDGPDRLSDGDGCDAAGAVGGAGAVGGARGGRRAVEARVWWLDGRPVLVGPHPDAPHVHAEPDLTEVSALVRRLGCRFVTTDLASRADGSGWRVVEVGDGQVSDLPRGIDASGLLASLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY35</accession>
    <name>A0A1E7MY35_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">HS99_0012240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030061268.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene4040"/>
    <dbReference type="EnsemblBacteria" id="ARF80459">
        <property type="protein sequence ID" value="ARF80459"/>
        <property type="gene ID" value="B6264_17470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33358">
        <property type="protein sequence ID" value="OEV33358"/>
        <property type="gene ID" value="HS99_0012240"/>
    </dbReference>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OEV33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="164" mass="18158" checksum="A8D52D891922936F" modified="2017-01-18" version="1">MSIDIANESGWDADEEAILDVARFALDKMRIHPQSELSVILVDGAAMEELHIQWMDLPGPTDVMSFPMDELRPGKEGEELPQGLLGDIVLCPEVAEQQGKAAPSKHSMDEELQLLTVHGVLHVLGYDHEEPEEEEEMFALQKRILDDWRAGRGLGGISPAPTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MY98</accession>
    <name>A0A1E7MY98_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387369.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3966"/>
    <dbReference type="EnsemblBacteria" id="ARF80522">
        <property type="protein sequence ID" value="ARF80522"/>
        <property type="gene ID" value="B6264_17845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33418">
        <property type="protein sequence ID" value="OEV33418"/>
        <property type="gene ID" value="HS99_0012620"/>
    </dbReference>
    <dbReference type="OMA" id="CPKEERD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="133" mass="14849" checksum="7672205FE0FBB3D0" modified="2017-01-18" version="1">MVTFDEFRAMALTLPEAAQEPTWGIETLRVRGKVFAMGSPDGDSVTVKASREDQAELIAAEPEVFSFARYVGRHGWVSVRLDLVDPEELQDLVTEAWRRTAPKRLVGELDARNSAQHPSKGPTRTPEGHARFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYA1</accession>
    <name>A0A1E7MYA1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030287556.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000854.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000021_gene3967"/>
    <dbReference type="EnsemblBacteria" id="ARF80521">
        <property type="protein sequence ID" value="ARF80521"/>
        <property type="gene ID" value="B6264_17840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33417">
        <property type="protein sequence ID" value="OEV33417"/>
        <property type="gene ID" value="HS99_0012615"/>
    </dbReference>
    <dbReference type="OMA" id="VIAWADY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="404" mass="42048" checksum="C1794E882B52787D" modified="2017-01-18" version="1">MRKPRRWKRVLIGAFAGCAVLADAGASAAAAAVSSEQLAISTPPAGSSAWVQDHSFGRSLPDPATTSPADAAAFFASLAPTELDRLVKQYPLVVGNYDGAPLDLRYRANRIALADERDAARVRAADKKLDADTRALAVSRANDVDRLLAPGRQILAFDPRGRGLVTEVWGDLADAERVSVVVPGSDADLGHFDQSAEPLRGAAGMARALYAEEQRQAPKTRTAVIAWTGYVTPSGLGPDAATSRLADVAAPRLQRLLAGLKETTRPDAPPALLCHSYGSVVCGTAAPKIPRAAASPSDTSGITDMMVFGSPGMGVQSAGELGGGVHVWATRNPSDWIGNVPFLEVGKLGHGADPTGNGFGAEQISSARAAGHNGYLTDGTDSLHNFAAISLGDYRDVVRAQPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYF3</accession>
    <name>A0A1E7MYF3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0012915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555549.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000043_gene6608"/>
    <dbReference type="EnsemblBacteria" id="ARF80571">
        <property type="protein sequence ID" value="ARF80571"/>
        <property type="gene ID" value="B6264_18135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33467">
        <property type="protein sequence ID" value="OEV33467"/>
        <property type="gene ID" value="HS99_0012915"/>
    </dbReference>
    <dbReference type="OMA" id="VDRHWNL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="274" mass="30061" checksum="9713A3F0EAF67976" modified="2017-01-18" version="1">MTIMAGMGSPTGTGVGPLLRGWRERRQLSQQHLALRADCSTRHLSFVENGRSHPSRELVLRLAEQLDVPVRERNTLLLAAGYAPHYPETPLDDPSMTALRGGVERLLAAHEPYPALVVDGEFRVLGANGALSLLLDGVAPHLLRPPFNAVRTALHPDGLAPRIVNHRQWRGHLLERLDRQLELVGTESLRRLRAEVGGYPEPAGDPAEDVTETGRPVALPLRLRHDGRVLSFLSTVTTFGTPLDLTVSELALETFLPADAETDRFLRSAVGPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MYG0</accession>
    <name>A0A1E7MYG0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0013005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000065">
        <property type="protein sequence ID" value="OEV33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030597185.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5148"/>
    <dbReference type="EnsemblBacteria" id="ARF80585">
        <property type="protein sequence ID" value="ARF80585"/>
        <property type="gene ID" value="B6264_18225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33480">
        <property type="protein sequence ID" value="OEV33480"/>
        <property type="gene ID" value="HS99_0013005"/>
    </dbReference>
    <dbReference type="OMA" id="TPSCDCT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="370" mass="37716" checksum="797868C7C73B405B" modified="2017-01-18" version="1">MPDQHCPTCGTARSTGCGCLPDRSLDDRSLDETAVLPHLEGPPLVRPYVPQAPDQVVDEAPPTADPFATTVLPPVQPGQQSHHGRPGPQGGPSAPPLGPDADAYATTVLPPVPGPAPDAYAAGATTVLPAVQPQPPVQPGGGNDLGYFPFGNGAPEPDSAAGGRAARRAAEQAERSPFAGRKGLIAGVGAGLLALTVGLAYAVTPSSGPTRQAEPVPVTTLAPAPVDPPTLAAPTTGAPAPTTEAPSPTPTRTARPTPTRTPTPTPTHSAAPTPTPTPTPPPTPTPTPTPTPTQTPRLLQLGMSGPDVRAMQQQLVNAECGFVDKSIVTGTFDDWTRTALQQYQRENRIKGENGVYGPKTQAVLTADPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ64</accession>
    <name>A0A1E7MZ64_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ddl</name>
        <name evidence="3" type="ORF">HS99_0038005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="1"/>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554879.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7706"/>
    <dbReference type="EnsemblBacteria" id="ARF78572">
        <property type="protein sequence ID" value="ARF78572"/>
        <property type="gene ID" value="B6264_06270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33740">
        <property type="protein sequence ID" value="OEV33740"/>
        <property type="gene ID" value="HS99_0038005"/>
    </dbReference>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="381" mass="40938" checksum="CFCDB1867AB3E71E" modified="2017-01-18" version="1">MSIEQSSPNPSAPKPRVALVFGGRSSEHAISVSTAGSVLRAIDRDKYDVLPIGITHEGRWALTSDEPARMAITDGRLPDVAHVAEAVDGQVALPVSPGSREVLLSEPGSAPKALGEVDVVFPLLHGPWGEDGTLQGLLELSGVPYVGNGVLASAAGMDKEFAKRILASHGLGVGHYTVVRPRDWETEQGRAAVRERVAELGLPVFVKPCRAGSSIGITKVRDLAELDAAIEEARRHDPKLIIEAGVSGREIECGVLEFEDGPRASVPAEVLVGEGFDFYDFEAKYIDSSEVRIPAELTDAEVAEIRRQAVAAFEAFGCEGLARVDFFLLEDGSWMINEINTMPGFTPISAYPKMWEASGVSYAELIDRLLQSALRRSTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZ66</accession>
    <name>A0A1E7MZ66_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0038035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000059">
        <property type="protein sequence ID" value="OEV33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554877.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7700"/>
    <dbReference type="EnsemblBacteria" id="OEV33745">
        <property type="protein sequence ID" value="OEV33745"/>
        <property type="gene ID" value="HS99_0038035"/>
    </dbReference>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="543" mass="55945" checksum="57FFF80C0ACFD16A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZC3</accession>
    <name>A0A1E7MZC3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0037825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000058">
        <property type="protein sequence ID" value="OEV33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000020_gene3775"/>
    <dbReference type="EnsemblBacteria" id="ARF78399">
        <property type="protein sequence ID" value="ARF78399"/>
        <property type="gene ID" value="B6264_05220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33771">
        <property type="protein sequence ID" value="OEV33771"/>
        <property type="gene ID" value="HS99_0037825"/>
    </dbReference>
    <dbReference type="OMA" id="IEWERGR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="21515" checksum="46A6AD5D06F23736" modified="2017-01-18" version="1">MTTEATTAPTNRTIWARRVTDGVEPKNVIIAVCLLIGGLRYGWPGLGWAAFAALFAAVIPTLFIQRGIRKGTLEDRHVGHRRRRLTVIPFIMGSVAVSFAVMIWAHAPRDLTAMVAAMFASLVPILVITVWWKVSVHTAVASGAVACLGIALGPVWLLLYPLVAVIGWSRVVLRDHTTAQTIVGAVVGALTAGLTFWAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZJ3</accession>
    <name>A0A1E7MZJ3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0038570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000063">
        <property type="protein sequence ID" value="OEV33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286417.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000395.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1092"/>
    <dbReference type="EnsemblBacteria" id="ARF78977">
        <property type="protein sequence ID" value="ARF78977"/>
        <property type="gene ID" value="B6264_08655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33643">
        <property type="protein sequence ID" value="OEV33643"/>
        <property type="gene ID" value="HS99_0038570"/>
    </dbReference>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="555"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="323"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="621" mass="68006" checksum="7BE232CB9C519768" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZM7</accession>
    <name>A0A1E7MZM7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0037340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000055">
        <property type="protein sequence ID" value="OEV33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551304.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000217.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000007_gene6378"/>
    <dbReference type="EnsemblBacteria" id="ARF78749">
        <property type="protein sequence ID" value="ARF78749"/>
        <property type="gene ID" value="B6264_07305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33888">
        <property type="protein sequence ID" value="OEV33888"/>
        <property type="gene ID" value="HS99_0037340"/>
    </dbReference>
    <dbReference type="OMA" id="FGVRAHR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="259" mass="27283" checksum="FDBB03D82C3E90ED" modified="2017-01-18" version="1">MAGAEELSVDGVSVELAGARLVHEVSLAAAAGQVVGLIGPNGSGKSTLLRCVYRVLRPAGGTVRLAGDDLHALTARRAATRVAALTQEHTAEFDFTVAEVVAMGRLPHRRGPGGPSAEDRERCTAALRKVRAEHLAGRGFLNLSGGEKQRVLFARALVQEPRLLVLDEPTNHLDIAHQLEVLALAREAGPTVLTALHDLNLAAGHCDRLYVLAAGRIAAAGPPAEVLRPALLAEVFGVRAAPVRHPETGALQLLFDRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZS4</accession>
    <name>A0A1E7MZS4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-dicitrate transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fecE</name>
        <name evidence="2" type="ORF">HS99_0010595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_046387175.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000717.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000012_gene1857"/>
    <dbReference type="EnsemblBacteria" id="ARF77764">
        <property type="protein sequence ID" value="ARF77764"/>
        <property type="gene ID" value="B6264_01435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33921">
        <property type="protein sequence ID" value="OEV33921"/>
        <property type="gene ID" value="HS99_0010595"/>
    </dbReference>
    <dbReference type="OMA" id="RCWIAMA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="292" mass="30780" checksum="5BE6420F3ACB0A3C" modified="2017-01-18" version="1">MTSTTDVNRLAAHSLGLRYGDRTILEGLDLELPGGAVTAIVGPNACGKSTLLRGLVRLLDPAAGTVTLDGADIHRMPARTLAKRMGLLPQQPVTPEAVTVEALVRLGRYPHQRMLSPWSKADQAAVEEALTRTGTAELRDRQVDRLSGGQRQRVWIALALAQETDLLLLDEPTTFLDLRHQLDVLDLVADLHAEAGRTVVMVLHDLGQAARYADHLVVLKDGRLAAAGPPTEVLTAELVESVFGVPCRVVPDPETGTPLVVPRARTRAAAAAPASASATAPASAAASASVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7MZT2</accession>
    <name>A0A1E7MZT2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0010830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551683.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000829.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2171"/>
    <dbReference type="EnsemblBacteria" id="ARF77803">
        <property type="protein sequence ID" value="ARF77803"/>
        <property type="gene ID" value="B6264_01670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV33950">
        <property type="protein sequence ID" value="OEV33950"/>
        <property type="gene ID" value="HS99_0010830"/>
    </dbReference>
    <dbReference type="OMA" id="WHWTDDT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="305" mass="32263" checksum="81B743824ACB7B09" modified="2017-01-18" version="1">MRATGPVLDSLRGLALGDAFGDRWFSAPVDEAPVDLAARLVRPAPWHWTDDTAMALVLVRHLTVHGEVRQDALAGEFAAEYAREYQRKYGPSMHRVLRAIGAGGDWRAITSGQFEGQGSYGNGAAMRVAPLGAWFAEDLAEVARQAELQALATHFHPEATAGSVAVALAAALAARSRGGRPPGRAELLTEVADRLPDSDVRSGLRIAARLPEHTSVRHAATVLGSGLLISAPDTVPFALWSAAGHLDSLPEAIWHTLEGWGDMDTTCAIAAGVVAARTGLADVPAPWLTACEDLPGWVAAAWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N022</accession>
    <name>A0A1E7N022_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-tRNA deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0011380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000054">
        <property type="protein sequence ID" value="OEV34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030551802.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000202.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000010_gene2287"/>
    <dbReference type="EnsemblBacteria" id="ARF77897">
        <property type="protein sequence ID" value="ARF77897"/>
        <property type="gene ID" value="B6264_02230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34039">
        <property type="protein sequence ID" value="OEV34039"/>
        <property type="gene ID" value="HS99_0011380"/>
    </dbReference>
    <dbReference type="OMA" id="PLPIYCD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="32"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="161" mass="16222" checksum="52A8ACB4D1F1D28C" modified="2017-01-18" version="1">MSPSLPVRSLAVAEALAAAGVAGEIVVLPDSARTAAEAAAALGCEVGAIANSLVFSCDGEPLLVMTSGAHRVDTAFLAGQLGAVEITRASAAQVREATGQAIGGVAPTGHPVPLRTVVDTALRQYEVLWAAAGHPHTVVPMTYEELLRVTGGVQSTVVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0N0</accession>
    <name>A0A1E7N0N0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HS99_0036880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285695.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000187.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6059"/>
    <dbReference type="EnsemblBacteria" id="ARF78150">
        <property type="protein sequence ID" value="ARF78150"/>
        <property type="gene ID" value="B6264_03780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34234">
        <property type="protein sequence ID" value="OEV34234"/>
        <property type="gene ID" value="HS99_0036880"/>
    </dbReference>
    <dbReference type="OMA" id="WMGPAKA"/>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OEV34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="27343" checksum="6B7713B5F45B1DEA" modified="2017-01-18" version="1">MSGILEGKRILITGVLMESSIAFHAAKLAQEQGAEIILTAFPRPSLTERIAKKLPKPVKVLELDVSNPEHLAGIADQVRETLPTLDGIVHSIGFAPQDALGGNFLDTPWESVATAMHVSAYSLKSLTMALLPLMQDGGAVVGLTFDAQFAWPQYDWMGPAKAALEATNRYLARYLGERDIRCNLVSAGPLGSMAAKSIPGFGDLADTWNHRSPLKWDLSDPEPAGRAIVALLSEWFPKTTGEIVHVDGGLHAIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N0T7</accession>
    <name>A0A1E7N0T7_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">HS99_0036645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000050">
        <property type="protein sequence ID" value="OEV34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285317.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000329.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000075_gene7647"/>
    <dbReference type="EnsemblBacteria" id="ARF78481">
        <property type="protein sequence ID" value="ARF78481"/>
        <property type="gene ID" value="B6264_05735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34307">
        <property type="protein sequence ID" value="OEV34307"/>
        <property type="gene ID" value="HS99_0036645"/>
    </dbReference>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OEV34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="311" mass="34156" checksum="B11EFF8D10940BC2" modified="2017-01-18" version="1">MSSSRVISIVGATAAGKSDLAVAIARSLGGEVINTDSMQLYRGMDIGTAKLTLDERGGVPHHLMDVWEVTEAASVAEYQRLARAEIDRLLAAGRTPVLVGGSGLYVRAAIDEMEFPGTDPEVRARLEAELEQAGPYALHRRLAELDPAAAEAILTSNGRRIVRALEVIEITGQPFTANLPSNTAVYEAVQIGVAVPRPELDERITLRVDRMWEAGLLDEVRELEKVGLREGRTASRALGYQQVLDHFAGECTEDEARAETVRATKRFARRQESWFRRDDRIHWLSRPAGTDPVELLERSLELIGRQGVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N198</accession>
    <name>A0A1E7N198_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Crystall_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0035715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000046">
        <property type="protein sequence ID" value="OEV34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34452">
        <property type="protein sequence ID" value="OEV34452"/>
        <property type="gene ID" value="HS99_0035715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015791">
        <property type="entry name" value="Antimic/Inh_G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015161">
        <property type="entry name" value="Sklp_toxin_b/g_crystallin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09076">
        <property type="entry name" value="Crystall_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198644" description="Crystall_2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Crystall_2" evidence="2">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="110" mass="12249" checksum="0F9584824C5EC537" modified="2017-01-18" version="1">MGVLAVLTAAAATLLPTTAARAVERIDCGGRDDFAKVWNYGYSGQLCFANDGWMAVRIYNVDRIDAGNNKVITYLGGGLGSWTVFTWERYDFNANQGHQVMMYDINLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1B1</accession>
    <name>A0A1E7N1B1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0036985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000052">
        <property type="protein sequence ID" value="OEV34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554602.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000627.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000032_gene6080"/>
    <dbReference type="EnsemblBacteria" id="ARF78169">
        <property type="protein sequence ID" value="ARF78169"/>
        <property type="gene ID" value="B6264_03885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34253">
        <property type="protein sequence ID" value="OEV34253"/>
        <property type="gene ID" value="HS99_0036985"/>
    </dbReference>
    <dbReference type="OMA" id="TFGAMRD"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="170" mass="17577" checksum="E8D8542A68D8FA4F" modified="2017-01-18" version="1">MHKTTGGATAPGPLAGARPAPGTSPGGDGGRSAGERGRTALAVGVVEKVAGMAAREVSGIHALGSGLARTFGAMRDRVPGGKSSVGRGIKAEIGEKQTAIDIALVVEYGVVIPELARQVRENIIDAVERMTGLEVVEVNIAVNDVHLPDEPEFEEEEEQVTAPGQRPRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1C7</accession>
    <name>A0A1E7N1C7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366961.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7073"/>
    <dbReference type="EnsemblBacteria" id="OEV34499">
        <property type="protein sequence ID" value="OEV34499"/>
        <property type="gene ID" value="HS99_0035465"/>
    </dbReference>
    <dbReference type="OMA" id="MTIAMST"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046096">
        <property type="entry name" value="DUF6114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19609">
        <property type="entry name" value="DUF6114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="148" mass="15699" checksum="2B68752941764D0B" modified="2017-01-18" version="1">MWNRTTAPWSQPREAIATARREFRVWRGTRPFWAGLLTFSGGLPILYFPFPYAHLSPGGLGLALSTTAGAGSLLIGCLLITLGVMLWLQQQVRIFAGVAAILLALLSVPVANFGGFFLGLLPGLIGGSLACAWAPPDNGGPVEPEIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1D8</accession>
    <name>A0A1E7N1D8_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_063737952.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34508">
        <property type="protein sequence ID" value="OEV34508"/>
        <property type="gene ID" value="HS99_0035510"/>
    </dbReference>
    <dbReference type="OMA" id="HEVSHTH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="31472" checksum="84C3F59561D21829" modified="2017-01-18" version="1">MSETPAPEVAVHQLDQATHDGGNGCIDVLSPPPGTDPEDCLHVALHVHGAASVRRGGASTVLAPGDLLIGTTPHPAGLLQDSECRMLRFRVPCFYLGVRHDDVRRAGGLLARGNEGIGSLASQFLRTLAAQARAHRARPGNHLARSVSDIVAILVTELLDRENPEHPTGAAELLSRIRAHIEENLADPDLSPESIARSQHISVRYLHKLFQQDGTTVGQWVRRRRLDACRRELERPSRRQSSVSAVAHRWGFVSHSHFSRAFREAFGVSPREWQAYATRTEGHNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1G4</accession>
    <name>A0A1E7N1G4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030550783.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2571"/>
    <dbReference type="EnsemblBacteria" id="OEV34516">
        <property type="protein sequence ID" value="OEV34516"/>
        <property type="gene ID" value="HS99_0035555"/>
    </dbReference>
    <dbReference type="OMA" id="IAYHLFP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="65"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="633" mass="68261" checksum="3BC3CEC4CE8CD4A2" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1H9</accession>
    <name>A0A1E7N1H9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMP-dependent synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000045">
        <property type="protein sequence ID" value="OEV34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030279061.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000212.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000066_gene7065"/>
    <dbReference type="EnsemblBacteria" id="OEV34525">
        <property type="protein sequence ID" value="OEV34525"/>
        <property type="gene ID" value="HS99_0035425"/>
    </dbReference>
    <dbReference type="OMA" id="GLNETCI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="498" mass="53725" checksum="663215A3EFC96476" modified="2017-01-18" version="1">MVNRITANAPTGGRISFARLDGTETLELVELHRRAGRLAGALAELGIGPGDRIGILAANSPQWVLLDLAALWLGAETAGFEPGKFEPDQQLVSRYGLRLLFTDRPAEAAGVLPLAEVDRLVEKADSAPEPVVWEPDRVTTVKFTSGSTGEPKGLGATAASIDSSLRAVQDMFHHRPGDDLFVFLPLSLLQQRYWIYSALRHGHDVTVSTYEAAFATLRRARPTVVMGVPAFFETARRHIGARAARSGKPVGEQAVQLFGDRIRYLWTGSAPAAPATLRFFNEAGLPIFEGYGLNETCIVAKNHPGASREGSVGRVVPGKEVLLDADGVISVRSDHPVNDHYAYAAPGDSEKVFRPGGIVRTGDLGLIDQDGYLYILGRADDVIVLENGKKIVVRPIEERLASGPAITEAVLFCPRQTELVAVVRPAHYPPDEAVIADALADANAALGKDERIARAIVAREPFTVENGLLTSQFKPRRPQIRAAYAADLANPQEGIHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N1J8</accession>
    <name>A0A1E7N1J8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0035365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000044">
        <property type="protein sequence ID" value="OEV34570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34570">
        <property type="protein sequence ID" value="OEV34570"/>
        <property type="gene ID" value="HS99_0035365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV34570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="92" mass="8966" checksum="9F5C800218177E2A" modified="2017-01-18" version="1">MVAELDVVGEGVDEEEAAAGFGGEVGEGVEVDRAESGGRGSTGEDVGVVRVAVAAGPVGSEASESRDGGAAAAVAAGRVAGRAREALRPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N233</accession>
    <name>A0A1E7N233_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555896.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000093.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000046_gene4628"/>
    <dbReference type="EnsemblBacteria" id="ARF81907">
        <property type="protein sequence ID" value="ARF81907"/>
        <property type="gene ID" value="B6264_26170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34731">
        <property type="protein sequence ID" value="OEV34731"/>
        <property type="gene ID" value="HS99_0009605"/>
    </dbReference>
    <dbReference type="OMA" id="HAVRTAN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26289" checksum="575D38B4127BC91F" modified="2017-01-18" version="1">MTEQTCRRFQGRVALVTGAASGIGAATARRLAAEGAAVIAVDIADSAGHAVVEAITAEGGQAEYRHGDVTSAAVWDGLAAHVRSRYGRLDVLHSNAYAVVVKPAHELTEVEWDTQLAVTLKASWLAVRAFAGTLRDSEGSVVLTSSVHALVGLPGHPAYAAAKGALCAMGRQLAVEYGPQVRVNTVVPGPIMTAAWDRVDEAGRADSVAETVAKRFGRPDEVAAAVAFLASSDASYVTGANLVVDGGWSVVKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2G3</accession>
    <name>A0A1E7N2G3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0009095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000043">
        <property type="protein sequence ID" value="OEV34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030554709.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000484.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ARF81992">
        <property type="protein sequence ID" value="ARF81992"/>
        <property type="gene ID" value="B6264_26695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34643">
        <property type="protein sequence ID" value="OEV34643"/>
        <property type="gene ID" value="HS99_0009095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="104" mass="11092" checksum="7DAA515736AB1276" modified="2017-01-18" version="1">MYVDVTMLDQECVRLAGLMAGQGMDRLTLPPTTSLEDDGTALEKAFTAELSASYHRIAAAGSDEECILPSLLMTMTGKLSALATEVALRSDRDVAEVIRSIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2Q2</accession>
    <name>A0A1E7N2Q2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Signal peptidase I</fullName>
            <ecNumber evidence="3 4">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HS99_0034685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 4"/>
    <dbReference type="EMBL" id="JPRF03000041">
        <property type="protein sequence ID" value="OEV34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043388843.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000559.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000035_gene7669"/>
    <dbReference type="EnsemblBacteria" id="ARF78535">
        <property type="protein sequence ID" value="ARF78535"/>
        <property type="gene ID" value="B6264_06075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV34964">
        <property type="protein sequence ID" value="OEV34964"/>
        <property type="gene ID" value="HS99_0034685"/>
    </dbReference>
    <dbReference type="OMA" id="NQLAYAF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OEV34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="299" mass="30876" checksum="01431D521D2F2904" modified="2017-01-18" version="1">MSTHEPPADRDGSPAPTGADSLSRSAVVSGPEPSPERQAAPDGGPVPEQSEDQPEAAEKDGEDGESGGDGESEPGRSRSRDLLLLVGICLAALLLVNAFVARPFTVPSGSMEDTLQPGDRLIANQLAYAFGGHPRRGDIVVFDGVGSFLPEPAGQPGFWDNVRSVGRDLGLVPAGNTVYVKRVIGVGGDRVRSTGPGAPLTVNGVPVDETSYLAPGDQPSDVAFDVVVPPGELFVLGDHRSASRDSRDHLGEPGGGFVPADKVIGRADWVVYPFSRLTGLDRPSAFTAVTGTGGHGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2U9</accession>
    <name>A0A1E7N2U9_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0034275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030558479.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35006">
        <property type="protein sequence ID" value="OEV35006"/>
        <property type="gene ID" value="HS99_0034275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198699" evidence="2">
        <location>
            <begin position="40"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="230" mass="23014" checksum="E58530C38D937A26" modified="2017-01-18" version="1">MSVRHLHAAASVIGRRNALRYLAIGAGSALVAACSSSTATKSAGSAGGADGGQAAPPTATATTTATTTATTATTAATGAPTGAAKPTVADRAFDAFVRGSWNLRSTNSRGEPMAGKVDVQTDGGGNGGWTITWDGASGKAATWRGSFLLRGGHLSLTLADGPEKLTHERAPEALDVPATVGAGLQLTLPWQPPGSSDSRSENLAVTYDGTTLTVVHTAGSSRTTHTCTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2W5</accession>
    <name>A0A1E7N2W5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0034400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552876.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4705"/>
    <dbReference type="EnsemblBacteria" id="OEV35027">
        <property type="protein sequence ID" value="OEV35027"/>
        <property type="gene ID" value="HS99_0034400"/>
    </dbReference>
    <dbReference type="OMA" id="TTGAMTK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="179" mass="19984" checksum="8D8438A0987A197B" modified="2017-01-18" version="1">MEPQHQQHPDDGGDHVALIQAAWHRERPDLDVSPQAVIGRLHRLAARLTAELTLVYRRYGLSEGEFDVLAALRRAGTPYERAPGELAAHTMVTTGAMTKRIDRLEHAGLVTRRTAEDDRRARVVALTDAGLRLFDEAFTAHMRNEHRLLSHLDPGEAAALETLLTAWHRRLEGAGPSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N2X5</accession>
    <name>A0A1E7N2X5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxygen-dependent FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0034460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000040">
        <property type="protein sequence ID" value="OEV35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552891.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000729.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000017_gene4717"/>
    <dbReference type="EnsemblBacteria" id="OEV35037">
        <property type="protein sequence ID" value="OEV35037"/>
        <property type="gene ID" value="HS99_0034460"/>
    </dbReference>
    <dbReference type="OMA" id="ITFAICR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019139">
        <property type="term" value="F:cytokinin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015345">
        <property type="entry name" value="Cytokinin_DH_FAD/cytokin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09265">
        <property type="entry name" value="Cytokin-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009198705" evidence="2">
        <location>
            <begin position="31"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="65"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="496" mass="52891" checksum="990A533118B129C8" modified="2017-01-18" version="1">MSRSGLSRRALIAGAGAAVVGWNTATRAWATAPQADVAELPSLDGSMTLRGEGLERFTSDFGHLVSAAPRAVLRPASVRDVQRVVEFARRHRIPVAVNGQSGDAAVVGQAGLESHSSYGQANPRGGIAVDARGLDRVVSIRPGEAVVEAGATWAQLTDAALAQGWMPPVLTDYLHLSVGGTLSVGGIGGAVQHHGLQTDTVRELEVVTGTGELVTASRERNRELFEAVLAGGGQVGIIVRATLALVPARERSTVFTLAYDDLDAYLADQQKVLADGRFDLQVGNVVRSADGQRWRYTAELVAYGDAGRPVDRQALLAGLSPVADGTSVVEQSWREYAFRVDAFAGYLRAAGFWGLPKPWLSLFLPASSVGVFMREAASSLTAADLGAGLLLFYPYARDRVRTPLAVLPQGEVGWHFDLLAFPAPGADVAGMLERNRRLYERAVQLGGKRYLIGAVPGMTAADWQRHYGALWERVEEAKRRFDPAGILTPGQGIHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N327</accession>
    <name>A0A1E7N327_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0034135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000039">
        <property type="protein sequence ID" value="OEV35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286633.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000407.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000030_gene399"/>
    <dbReference type="EnsemblBacteria" id="ARF78904">
        <property type="protein sequence ID" value="ARF78904"/>
        <property type="gene ID" value="B6264_08225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35101">
        <property type="protein sequence ID" value="OEV35101"/>
        <property type="gene ID" value="HS99_0034135"/>
    </dbReference>
    <dbReference type="OMA" id="KMSPWAQ"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="444" mass="48371" checksum="AAB7102FB5DE0F1B" modified="2017-01-18" version="1">MVSSKSRRTPDRRTYVLDTSVLLADPLAMTRFEEHEVVLPVVVVTELEAKRHHPELGYFARQALRLLDDYRIRHGRLDEPIPVGELGGTIRVELNHSDVSILPVGYRAGGGEADTRILAVARNLQAEGYDVTVVSKDLPLRIKASSVGLLAEEYRAELAITSGWTGMSELHVAADQVDALFAAGHDAAVDVDGTDELPVHTGLVLTSERGRALGRVTGDGRVRLVRGEREAFGLRGRSAEQRVALDLLLDPDIGIVSMGGRAGTGKSALALCAGLEAVLERRQHRKVMVFRPLYAVGGQELGYLPGSEAEKMGPWAQAVFDTLSAVTTPDVIEEVISRGMLEVLPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGQGSRVVLTHDVAQRDNLRVGRYDGVVAVVEKLKGHPLFAHITLTRSERSPIAALVTEMLEDIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3B1</accession>
    <name>A0A1E7N3B1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0033910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000038">
        <property type="protein sequence ID" value="OEV35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030285479.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000515.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000027_gene4483"/>
    <dbReference type="EnsemblBacteria" id="OEV35177">
        <property type="protein sequence ID" value="OEV35177"/>
        <property type="gene ID" value="HS99_0033910"/>
    </dbReference>
    <dbReference type="OMA" id="ASCFLVH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="99" mass="11013" checksum="5ABE6E3B10A8652A" modified="2017-01-18" version="1">MATDYDTPRKTDDELNEDSIEELKARRNDKGGSSVDVDEFDAAEGMELPGADLSNEELAVRVLPKQADEFTCMSCFLVHHRSQLYSEKNGNPICRDCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3D4</accession>
    <name>A0A1E7N3D4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030289435.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1379"/>
    <dbReference type="EnsemblBacteria" id="ARF79268">
        <property type="protein sequence ID" value="ARF79268"/>
        <property type="gene ID" value="B6264_10370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35208">
        <property type="protein sequence ID" value="OEV35208"/>
        <property type="gene ID" value="HS99_0033340"/>
    </dbReference>
    <dbReference type="OMA" id="DNDFEMH"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="287" mass="29950" checksum="6B99E1B11D0EF4F3" modified="2017-01-18" version="1">MTTAPARPDEKRPLGGSYDPARTTGGGLGAELDRLEAQAALSFPEELRILRELGLPTGGTVLELGAGPGAVTRRLRAALPADTALIAADIDGELLAHAAGPGVTLLVADGAELPLPDASVDFVLLRYVLQHVPDPVAVLAEVRRVLRPGGRVAVTEVDSALWGAAEPSYPELAGVHAKMAAAQRADGGDRSIGRRLPRLLRAAGFGQPVLRPFATTNDDHPTDAFAPQLGPQRLEPLVARGVLSLAELALAADRWNRFRSDPDAWVMLLGLTVAATAPAGRGPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3G0</accession>
    <name>A0A1E7N3G0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000040_gene1365"/>
    <dbReference type="EnsemblBacteria" id="ARF79281">
        <property type="protein sequence ID" value="ARF79281"/>
        <property type="gene ID" value="B6264_10445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35220">
        <property type="protein sequence ID" value="OEV35220"/>
        <property type="gene ID" value="HS99_0033410"/>
    </dbReference>
    <dbReference type="OMA" id="SAHEPPG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="227" mass="20288" checksum="CFE0BE3AEEFC00DC" modified="2017-01-18" version="1">MASVRAVGSEAAVREAVALRSRAVRAAAVLAVAGLGLTGCMSVGPAAEEKHGGVAPVGQAGPAGRPGASGGPSASPGAGHPGGASGRAEHQGGLQAENAPAGAATAAPGELTPGVNGPVAGVVPVPGAPAPESAPGGNASAGGANSSPVPHPGGSSGGGSTGTGGTGGTGEGRSGGGSGTPSATPSGHPSGTPEPERTTPAATVPPVPDPSSGSSGSSAPSPHAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3I0</accession>
    <name>A0A1E7N3I0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0033550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000037">
        <property type="protein sequence ID" value="OEV35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556693.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000053_gene6139"/>
    <dbReference type="EnsemblBacteria" id="ARF79303">
        <property type="protein sequence ID" value="ARF79303"/>
        <property type="gene ID" value="B6264_10585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35240">
        <property type="protein sequence ID" value="OEV35240"/>
        <property type="gene ID" value="HS99_0033550"/>
    </dbReference>
    <dbReference type="OMA" id="FGAPMQR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="200" mass="22367" checksum="7604DC921592623C" modified="2017-01-18" version="1">MTAKLPSPVTLTGHHIRLEPLARHHLADLWATIGSEPDVWRWTMNLPPATEEELGAILDARIAEGASGESVEFAAVDLASGTAVGVTGYYDLNAKDEYLEIGGTMYARSVWRTAVNTEAKLLLLTHAFEDLGMGRVFWKTDALNERSRNAILRLGAQYEGTFRRHRLRPTGVWRDSVYFSMLADEWPAAKSRLEERLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3K2</accession>
    <name>A0A1E7N3K2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HS99_0032985</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000036">
        <property type="protein sequence ID" value="OEV35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033348072.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000001_gene5290"/>
    <dbReference type="EnsemblBacteria" id="ARF80704">
        <property type="protein sequence ID" value="ARF80704"/>
        <property type="gene ID" value="B6264_18925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35278">
        <property type="protein sequence ID" value="OEV35278"/>
        <property type="gene ID" value="HS99_0032985"/>
    </dbReference>
    <dbReference type="OMA" id="IFPLGHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OEV35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="350" mass="38222" checksum="7E8EFF3DA62FE38E" modified="2017-01-18" version="1">MSEDKLPEPHGSAGEVADHGNPFADPGLPAHEPRRTDIDERAAKRAERQVSLMFVISMIATIGFIASYVAIDPDRIVYIFPLGHVSALNFALGLTLGVALFMIGAGAVHWARTLMSDVEMPSERHPIEASDEVRNDVIEQFKTGAAESGFGRRKMIRNTLIGSMALVPLSGVVLLRDLGPLPEKKLQETGWREATPAKPLALVNMSTMQPMKPEDLVVGSLTFAMPEGLTTHDEDFQQRIAKDALMLVRIAPEDIKDDKSKDLGFEGILAYSKICTHVGCPISLYEQQTHHALCPCHQSTFDLADGARVIFGPAGHPLPQLKITTDDKGNLVATGDFEKPVGPSFWERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3U7</accession>
    <name>A0A1E7N3U7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278685.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35360">
        <property type="protein sequence ID" value="OEV35360"/>
        <property type="gene ID" value="HS99_0032620"/>
    </dbReference>
    <dbReference type="OMA" id="MTERYAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="61" mass="6860" checksum="7F57462F09E9CD97" modified="2017-01-18" version="1">MTERYAILPADAPHGASYQVWVVRDRTTTHLVKALPPADEPLRFYSYAQALAWTRTNSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N3V3</accession>
    <name>A0A1E7N3V3_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HS99_0032570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000035">
        <property type="protein sequence ID" value="OEV35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278705.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000294.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000004_gene2425"/>
    <dbReference type="EnsemblBacteria" id="OEV35352">
        <property type="protein sequence ID" value="OEV35352"/>
        <property type="gene ID" value="HS99_0032570"/>
    </dbReference>
    <dbReference type="OMA" id="MGEHPRL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OEV35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="226" mass="23610" checksum="71444627DFE77D0A" modified="2017-01-18" version="1">MTQPTQQTTWNAVDAYFSEQLVGHDPALEAATAAADAAGLPKIAVAPNQGKLLHLLALTQGARRILEVGTLGGYSTIWLARALPADGTLISLELDPRHAEVARGNLARAGLGEVAEVRVGRAADSLAALVEQGEEPFDLVFIDADKPSNPEYFRRALQLTGPGSLIIVDNVVRGGAIADAASTDPAIVGTRTLHELIAAEPRVTGTSVQTVGSKGYDGFTLVRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N4B1</accession>
    <name>A0A1E7N4B1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0032040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000033">
        <property type="protein sequence ID" value="OEV35528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030278208.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000016_gene5486"/>
    <dbReference type="EnsemblBacteria" id="ARF79417">
        <property type="protein sequence ID" value="ARF79417"/>
        <property type="gene ID" value="B6264_11230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35528">
        <property type="protein sequence ID" value="OEV35528"/>
        <property type="gene ID" value="HS99_0032040"/>
    </dbReference>
    <dbReference type="OMA" id="IVEWYRP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="195" mass="21382" checksum="410EB88C9F340EE0" modified="2017-01-18" version="1">MADHTTRTAYTVESLLAVTVDVFNERGYDGTSMEDLSRAAGISKSSIYHHVRGKEELLRLAVGRALDGLFAILAEPAAVQGPAVERLEHVVRRTAEVLLAELPYVTLLLRVRGNTATELWALERRRDFDHQVAELVRAAVADGALRGDVEPRLATRLLFGMINSIVEWYRPGLKAADGVADAVVHLAFDGLRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N524</accession>
    <name>A0A1E7N524_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0007890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030281440.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000166.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000006_gene751"/>
    <dbReference type="EnsemblBacteria" id="ARF80996">
        <property type="protein sequence ID" value="ARF80996"/>
        <property type="gene ID" value="B6264_20665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35785">
        <property type="protein sequence ID" value="OEV35785"/>
        <property type="gene ID" value="HS99_0007890"/>
    </dbReference>
    <dbReference type="OMA" id="VGQRAWP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="254" mass="25688" checksum="4D336175D3B32B1B" modified="2017-01-18" version="1">MNDENVVEQRVVVVTGAGTGIGRETARAFAAEGARVVAVGRRAEPLAETAAAHPGLIEPLVADVTGPDAPETIVGAALERYGRLDVLVNNAGIVQSGQAVGGYRRAGIETLLATNLVAPVLLGQAALPALGESRGVVVNVSTAVGQRGWPGNAVYAAGKAALETITRSWAVELAPRGIRVVAVAPGAIDTPIGEHAGHGPEQSAAIRAWQLAHTPLGRIGRPAEVAWAITQLASPQASFVTGVVLSVDGGALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5F4</accession>
    <name>A0A1E7N5F4_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0008605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030286252.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000408.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000023_gene7289"/>
    <dbReference type="EnsemblBacteria" id="ARF81120">
        <property type="protein sequence ID" value="ARF81120"/>
        <property type="gene ID" value="B6264_21380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35909">
        <property type="protein sequence ID" value="OEV35909"/>
        <property type="gene ID" value="HS99_0008605"/>
    </dbReference>
    <dbReference type="OMA" id="QWWQVVE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="270" mass="29233" checksum="CB48503EAF7372E9" modified="2017-01-18" version="1">MGSLTGQVALVTGAGRGIGREIAIGLAAEGMAVGLVGRTHDTLTATLKECVKHGSRGVAVTADVCRHGSVREAVRLVERDLGPIDLLVNNAGLVDREEVPLWETDPNQWWQVVETNLRGPYNLLRCVLPGMVTRRSGRVVNLSSGFALRPDGNYTAYATSKGALLQLSDNMADSLARHHVVVLDISPGAVPTDMTAGMPMFRDMKAWASIPYMVAVTVDAARGRFDALHGRFIHAGRDDLEELVQRAEEIRTADARTLRLRPYKGDDPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N5J0</accession>
    <name>A0A1E7N5J0_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0007430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000032">
        <property type="protein sequence ID" value="OEV35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV35961">
        <property type="protein sequence ID" value="OEV35961"/>
        <property type="gene ID" value="HS99_0007430"/>
    </dbReference>
    <dbReference type="OMA" id="VWAVIHE"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="282" mass="31313" checksum="BE15E21A0F54AC42" modified="2017-01-18" version="1">MAVSTVRRRRLGGVLRKLREERKLTAEVVAEATGMSQPKLTRIETAHTAAKIEDVNKLLDYYGCDDEDFRAGLIAITKDGSKRGWWLSYRDVLHATATDLILLESDASTLRTYEPAFIPGLFQTPEYARVVIDRLRTESSGTVEDMVQVRMARQSILTRPNPVQVWAVIHETALCANANRPDIMSAQLDKLVSLSRLSNVNIQVMPAGAAIHPGMAGAFALLGFPQRADLDVVLAEGLISSLWVEHPNDVEIYRAKFQEITAEALPVDSSLDFITAQRDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6R2</accession>
    <name>A0A1E7N6R2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000027">
        <property type="protein sequence ID" value="OEV36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030280536.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000034_gene7734"/>
    <dbReference type="EnsemblBacteria" id="ARF82327">
        <property type="protein sequence ID" value="ARF82327"/>
        <property type="gene ID" value="B6264_28720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36381">
        <property type="protein sequence ID" value="OEV36381"/>
        <property type="gene ID" value="HS99_0029945"/>
    </dbReference>
    <dbReference type="OMA" id="NSCLMHI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="253" mass="26900" checksum="4DDDB44C06B32254" modified="2017-01-18" version="1">MRVALFATCVNDALFPATAVATVRLLERLGVTVDFPAGQTCCGQPQYNTGYRRACEPLVRRTARAFAGYDHVVTPSGSCVAMVRDNYPRIGARAATEGRGGELTDAATALAPRVIELTEFLVDVLGVEDVGAHFPYTVTYHPSCHGLRMLGLGERPLRLLRAVKGLELVELPGAEECCGFGGTFAVKNAAVSAAMAEDKLANALGTGAQVLCGADNSCLLHLGGTLRRRGDALRPLHLAEILASTEEHPWRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Y2</accession>
    <name>A0A1E7N6Y2_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0029460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36462">
        <property type="protein sequence ID" value="OEV36462"/>
        <property type="gene ID" value="HS99_0029460"/>
    </dbReference>
    <dbReference type="OMA" id="RTDAWRS"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="263" mass="28280" checksum="2B83CC307C6027A4" modified="2017-01-18" version="1">MHHHRTPGGRPQGRPEGPLARRDGWEVHGRDGELSCVDPSGLVRWRQPCPGRPNAAHISAGRVLVTTDSFEYTTRGHLGPALLLDLADGAPVAELRGERGAAVGGGRFVLGLEGYGAFDTWAHDRDGAVVDSWRSYGHYVVGDGLRVVETDRRRPTGSRVVRLLPGGAVERGPLLTDPQAPEPLALPDGTLLVLDAGVLRAVGRELDDAVLAELLPLAPEEQHRFTGGLRRTAEGLNATLVERHPTRMGSYTTHTWVLGLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N6Z8</accession>
    <name>A0A1E7N6Z8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0029380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366371.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene210"/>
    <dbReference type="EnsemblBacteria" id="ARF82246">
        <property type="protein sequence ID" value="ARF82246"/>
        <property type="gene ID" value="B6264_28225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36449">
        <property type="protein sequence ID" value="OEV36449"/>
        <property type="gene ID" value="HS99_0029380"/>
    </dbReference>
    <dbReference type="OMA" id="SISHYYY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="248" mass="26261" checksum="F44A4F649096C694" modified="2017-01-18" version="1">MSDDRSVRRTTDPEQTVQDERTVSFLRFGVGAIGVLLPPALPLGNWLADEVTGRSTDGFWPASMSAAYYTGTRNVFVGALCALGVFLVCYRFDRRDDRWSTAAGLFALGVALCPPAPQDPTGLQRTVGVFHLVFAALLFVMLALFCLYSFRNPRSTQPARVGAAYLAAGVLILVALVAAAVAGLSGFGADWAVRPMYLCEWVATWAFGAAWIGAAVELAAGRGGRAGSGALPRQAVGLEVRGPEASQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N717</accession>
    <name>A0A1E7N717_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0029515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000026">
        <property type="protein sequence ID" value="OEV36491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000029_gene182"/>
    <dbReference type="EnsemblBacteria" id="OEV36491">
        <property type="protein sequence ID" value="OEV36491"/>
        <property type="gene ID" value="HS99_0029515"/>
    </dbReference>
    <dbReference type="OMA" id="DATACAI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV36491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="830" mass="86890" checksum="2D4A3D3BBD2AD280" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7T8</accession>
    <name>A0A1E7N7T8_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0027325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030552941.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36738">
        <property type="protein sequence ID" value="OEV36738"/>
        <property type="gene ID" value="HS99_0027325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV36738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="102" mass="10839" checksum="CB4B59B30CD7B19C" modified="2017-01-18" version="1">MVMLPECRRSGQSHGQIAAQTVLTGPSTATSRQPPDPAPPCDFDAPYPEAGRYSPYLSPKEVPKVFPKCGHHRGHRVFGPRPAAVANHCSSAGPTVGRVGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N7V7</accession>
    <name>A0A1E7N7V7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0027490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000023">
        <property type="protein sequence ID" value="OEV36759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV36759">
        <property type="protein sequence ID" value="OEV36759"/>
        <property type="gene ID" value="HS99_0027490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="84" mass="8827" checksum="50CF697CB78738AD" modified="2017-01-18" version="1">MIVLGLTEAVHGLGRTPPVPARLAEVAEGWLGDCPAWRSARWRAAETDSAPATGACRLQAAARRAQETDVAGASGGWCSRWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8H7</accession>
    <name>A0A1E7N8H7_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HS99_0027195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000022">
        <property type="protein sequence ID" value="OEV36968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000024_gene6812"/>
    <dbReference type="EnsemblBacteria" id="OEV36968">
        <property type="protein sequence ID" value="OEV36968"/>
        <property type="gene ID" value="HS99_0027195"/>
    </dbReference>
    <dbReference type="OMA" id="WANSWIR"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OEV36968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="401" mass="41051" checksum="FAA40B430A99746E" modified="2017-01-18" version="1">MLVAFTTVTNLADGVMKIALPLVATSLTESPALISGVAMSLSLPWLLSALHIGVLVDRVDRRKLVWLANGIQVLVGGALLALAVTDLLNLPVIYACGAALGIAEVIAGTSAAALVPDVVAVSGRERANALVAGAETVCLEFVGPFVGGLLVGVGVSFALGATLVGYVLTAAVLVLLVYRYRPATASGGAAAAPSVRAQIGEGLGFLFRHRLLRMLAAVVTVLGSCWGAWFALMPLYATGAMGLTSADYGLLVGALGIGGVAGSLVVGWFNRLFGRRWAMMINIFLTGAMMAAPALSTDRWAVGCAALLGGMGGTLWTVNVRTVMQTLVPSTMMGRFGAVFRLFAFGSGPVGAGVAGALAEWFSAPTAMAAFAIACLLAFLPLARVFTAAVEADLDNLLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N8S6</accession>
    <name>A0A1E7N8S6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0004510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000048_gene7405"/>
    <dbReference type="EnsemblBacteria" id="ARF81639">
        <property type="protein sequence ID" value="ARF81639"/>
        <property type="gene ID" value="B6264_24480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37089">
        <property type="protein sequence ID" value="OEV37089"/>
        <property type="gene ID" value="HS99_0004510"/>
    </dbReference>
    <dbReference type="OMA" id="RMAVQCK"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="191" mass="20154" checksum="13B8273391B48CC4" modified="2017-01-18" version="1">MLLVGIAAVAGLAVVSVAVHWLVQHLVLVAGLLVVGAGAGVAVLRSRVRVRQRELDVRAAQLRHIEPFLSMTPKAFEHALADLCRRDGCTKVSVVGGAGDLAADVLATTPTGQRILIQAKRYGPRTFVGSQDVQRVNGTYRDVHRCDLAAVVTTSSFTKAAAAFCAQVGIRAVDRRALALWAEGTGGPPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N950</accession>
    <name>A0A1E7N950_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030556629.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000270.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000052_gene6204"/>
    <dbReference type="EnsemblBacteria" id="ARF81561">
        <property type="protein sequence ID" value="ARF81561"/>
        <property type="gene ID" value="B6264_23990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37174">
        <property type="protein sequence ID" value="OEV37174"/>
        <property type="gene ID" value="HS99_0005000"/>
    </dbReference>
    <dbReference type="OMA" id="RQYMTAL"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="199" mass="22214" checksum="0213EEF380FA4046" modified="2017-01-18" version="1">MDVGAVLIAMTGVAGTLGAALLTQRGADRVKKRELEMSHAIQERRENRELRRRCYTELHRDARQFATALSRHLYVMRDRAPGDEDVQALERVKDAHRDRWSETLMIAPDTVIGPANKLNDALTRVYGQIKRIEQGNPRRGETLRSAAEGQHALWPLIRATREAMRADLGVTGAAPWPESTSADDPAMIGDFEETDGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N952</accession>
    <name>A0A1E7N952_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0005330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555260.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1349"/>
    <dbReference type="EnsemblBacteria" id="OEV37225">
        <property type="protein sequence ID" value="OEV37225"/>
        <property type="gene ID" value="HS99_0005330"/>
    </dbReference>
    <dbReference type="OMA" id="LMCGIAY"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="193" mass="20330" checksum="AFC43B07EEDC15CD" modified="2017-01-18" version="1">MTTTPLRKDAARNWERIVAVARELVDQGTPLQLNDVARRAGLGVGTVYRHFATPEALLEAVATPCLEALAAHGRQALADTDAWRALESFLTRTVEAQVTDASVAPVAAASVDALPRTTELKESLWCTGTALLDRARAAGAVRPDLAAADLVPLMCGIAYAVDVHGSAPADRIDTAHRYLAALLGGLRATPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9B1</accession>
    <name>A0A1E7N9B1_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEDD_Tnp_IS110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030555137.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000039_gene1281"/>
    <dbReference type="EnsemblBacteria" id="OEV37282">
        <property type="protein sequence ID" value="OEV37282"/>
        <property type="gene ID" value="HS99_0005670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="113" mass="12150" checksum="53DFA8AFEAC25A86" modified="2017-01-18" version="1">MPFVGDDWAQDHHDVELMDAMGRRLSKARLPEDVAGIERLHAMIGAELGEDSKAEVVIGIETDRGPWVQPLIAAGYTVYAVNPLQASRYRERLAVSGAKSDTADAATTGSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-04-07" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9E6</accession>
    <name>A0A1E7N9E6_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0005850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481035.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37311">
        <property type="protein sequence ID" value="OEV37311"/>
        <property type="gene ID" value="HS99_0005850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="106" mass="11689" checksum="05CADFCFCF219E14" modified="2017-01-18" version="1">MHRTDPKLDGRRLVVACGREHGRQLVDQYRGRPVVEPEQWAAKIMRALDQHSEGLSETELAEATGLTPAEIEIGVRWQAMAAVDWHARFGAVGLQEPAGAGVLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9M1</accession>
    <name>A0A1E7N9M1_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0006305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050366129.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000170.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000051_gene5397"/>
    <dbReference type="EnsemblBacteria" id="ARF82500">
        <property type="protein sequence ID" value="ARF82500"/>
        <property type="gene ID" value="B6264_29780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37386">
        <property type="protein sequence ID" value="OEV37386"/>
        <property type="gene ID" value="HS99_0006305"/>
    </dbReference>
    <dbReference type="OMA" id="HRNSVND"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="1266" mass="134951" checksum="61D7455277D6A73C" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9P5</accession>
    <name>A0A1E7N9P5_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-ACP reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0003890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030557237.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000153.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000063_gene145"/>
    <dbReference type="EnsemblBacteria" id="ARF83057">
        <property type="protein sequence ID" value="ARF83057"/>
        <property type="gene ID" value="B6264_25125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37411">
        <property type="protein sequence ID" value="OEV37411"/>
        <property type="gene ID" value="HS99_0003890"/>
    </dbReference>
    <dbReference type="OMA" id="WPETPEI"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OEV37411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="255" mass="26954" checksum="FE73F2371AF7748C" modified="2017-01-18" version="1">MTQRLDGRVAVITGAGSGIGLATARRFAAEGAKVVCVDLDPETGAKAANEVGGLFIQADVTDEAAVRDLFQRAVDEYGRLDITFNNAGISPPDDDSILTTGLEAWKRVQEVNLTSVYLCCKYAIPHMQRQGKGSIINTASFVAVMGAATSQISYSASKGGVLAMSRELGVQFAREGIRVNALCPGPVNTPLLQELFAKDPERAARRLVHIPLGRFAEPEEIAAAVAFLASDDSSFMTANTFLVDGGISGAYVTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7N9T0</accession>
    <name>A0A1E7N9T0_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HS99_0005685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000021">
        <property type="protein sequence ID" value="OEV37450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_043481072.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37450">
        <property type="protein sequence ID" value="OEV37450"/>
        <property type="gene ID" value="HS99_0005685"/>
    </dbReference>
    <dbReference type="OMA" id="YNYYCLA"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024937">
        <property type="entry name" value="Domain_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01348">
        <property type="entry name" value="Intron_maturas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="568" mass="64786" checksum="C6466C0138A54A9A" modified="2017-01-18" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA74</accession>
    <name>A0A1E7NA74_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HS99_0026060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000015_gene7954"/>
    <dbReference type="EnsemblBacteria" id="OEV37586">
        <property type="protein sequence ID" value="OEV37586"/>
        <property type="gene ID" value="HS99_0026060"/>
    </dbReference>
    <dbReference type="OMA" id="ARCLMIG"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OEV37586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="262" mass="27234" checksum="D172AE429A8DAEB8" modified="2017-01-18" version="1">MSGGVPVLSTAALVEGFTRLGVRPGMVLHVQASLRALGPVEGGAGGVVDALCEVLGPDGTLVAYTATPENSATSRIHQEAVAGLSPAEVEAHRARMPRFDPAATPASPTMGALSEAVRTRPGALRSGHPQTSWTALGARAEEITAGHPLTSHLGPESPLGRLYELDARVLMLGVGMARFTAFHLADLRQPGVRLREYRCVGADGWTAFRAPDLDDLHFAELGDRVLGAAAGISGARIGTADCRLVPVREAVDLADGFLRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NA75</accession>
    <name>A0A1E7NA75_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HS99_0026610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000020">
        <property type="protein sequence ID" value="OEV37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000013_gene1110"/>
    <dbReference type="EnsemblBacteria" id="OEV37600">
        <property type="protein sequence ID" value="OEV37600"/>
        <property type="gene ID" value="HS99_0026610"/>
    </dbReference>
    <dbReference type="OMA" id="HEFPPGF"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018650">
        <property type="entry name" value="STSV1_Orf64"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09852">
        <property type="entry name" value="DUF2079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OEV37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="492" mass="53769" checksum="787FD8FCC55F7CD6" modified="2017-01-18" version="1">MQGWSSVSLGGFDLGIFDQGVRGYAHFHLPVSTLKYYHHEFPPGFSLLGDHFSPVLALLAPLYWIWDDPRSLIIGQALLFALGVPLIRRIAAHAFAAAEQRTARRAADLAGLAYALGWPLLVASRVGFHEVAFAVPLTLLMLERGQARRYGTVVLAAVLLCCTKEDLGLLVGAYGLVLLLRTRRTADRAGRFTGIGLLLGGPIASAVAIKWLIPAMGGEPGYYWNYKALGDDGGDALRNLLHDPFLLVQAAFDQPLKPLLLLWLFGTLFLLPLRSATVLCMLPLLAERILSSNPNHWSIARHYDSMLWPVLLTATVEVLGRMSSVERPERTRRRARLLGLGTVGVALVAAVPIGLLQLAVPSSWEPRASEAALVRAARLIPDGAPVEADNQIAPRLTARTDVVLVDGTPRGREYVLTRSDKRSFPFKTDKEQADRIELLLAHGYRQLWAEDGVVLLHRESTEPVPGEHVPGPGSKPVQDEVPSDVGHNLFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NAD2</accession>
    <name>A0A1E7NAD2_KITAU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secE</name>
        <name evidence="2" type="ORF">HS99_0025315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000019">
        <property type="protein sequence ID" value="OEV37628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030290444.1">
        <property type="nucleotide sequence ID" value="NZ_LBHA01000226.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000081_gene6247"/>
    <dbReference type="EnsemblBacteria" id="ARF79883">
        <property type="protein sequence ID" value="ARF79883"/>
        <property type="gene ID" value="B6264_14100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37628">
        <property type="protein sequence ID" value="OEV37628"/>
        <property type="gene ID" value="HS99_0025315"/>
    </dbReference>
    <dbReference type="OMA" id="VLWVFGN"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OEV37628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000037395"/>
        </source>
    </evidence>
    <sequence length="108" mass="11601" checksum="E5F4626F36C8312D" modified="2017-01-18" version="1">MTETTGSTATPESGNPEGTDGAAETAAAEDGKKSGKQKKSGKRAKKGLFARMGLFYRQIIAELRKVVWPTRSELTNYTAVVVTFVVVVMGFVYGLDYGFAKLSLLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1E7NB17</accession>
    <name>A0A1E7NB17_KITAU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HS99_0025060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kitasatospora aureofaciens</name>
        <name type="synonym">Streptomyces aureofaciens</name>
        <dbReference type="NCBI Taxonomy" id="1894"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Streptomycetales</taxon>
            <taxon>Streptomycetaceae</taxon>
            <taxon>Kitasatospora</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zhang J.E."/>
                <person name="Yang H."/>
                <person name="Guo J."/>
                <person name="Deng Z."/>
                <person name="Luo H."/>
                <person name="Luo M."/>
                <person name="Zhao B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing, assembly and comparative genomics of S. aureofaciens ATCC 10762.</title>
            <authorList>
                <person name="Gradnigo J.S."/>
                <person name="Johnson N."/>
                <person name="Somerville G.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC 12843 / NCIMB 8234 / A-377</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JPRF03000018">
        <property type="protein sequence ID" value="OEV37875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_050367114.1">
        <property type="nucleotide sequence ID" value="NZ_JPRF03000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1894.JOER01000054_gene6004"/>
    <dbReference type="EnsemblBacteria" id="ARF82584">
        <property type="protein sequence ID" value="ARF82584"/>
        <property type="gene ID" value="B6264_02905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="OEV37875">
        <property type="protein sequence ID" value="OEV37875"/>
        <property type="gene ID" value="HS99_0025060"/>
    </dbReference>
    <dbReference type="OMA" id="GHLIHHP"/>
    <dbReference type="Proteomes" id="UP000037395">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type=